| Health Status and Performance of United States Air Force Airmen Following Mild Traumatic Brain Injury |
Sep-2009 |
8 pages |
| Authors:
Timothy S Wells; AIR FORCE RESEARCH LAB WRIGHT-PATTERSON AFB OH
|
 | The objectives of this study are as follows: (1) determine the agreement between the Centers for Disease Control (CDC) definition of mild traumatic brain injury (mTBI) and the clinical judgment of a board-certified neurologist based upon medical records review; (2) utilize a historical prospective study design in a large, well-documented population to determine the relation between mTBI and mental disorders. including depression, PTSD, anxiety disorders, sleep disorders, fatigue, headache, and ... |
|
| The Effects of Ammonium Perchlorate on Reproduction and Development of Amphibians |
Jan-2008 |
44 pages |
| Authors:
James Dumont; OKLAHOMA STATE UNIV STILLWATER DEPT OF ZOOLOGY
|
| The objectives of this SERDP project were to examine the long-term effects of perchlorate on developing amphibians (e.g., growth, metamorphosis) and on the general health and reproductive capacity of adult females. The studies examined the effects of perchlorate present in the water as well as perchlorate available through the food chain. Because perchlorate competes for iodine binding sites in the thyroid, the addition of iodine to culture water was examined ... |
|
| Suppression of Prostate Tumors by INK4C and PTEN |
DEC 2007 |
22 pages |
| Authors:
Yue Xiong; NORTH CAROLINA UNIV AT CHAPEL HILL
|
| Work during this entire funding period thoroughly characterized mutant mice in the cyclin-dependent kinase (CDK) inhibitor p18Ink4c, which causes hyperplastic cell growth in various tissues including the prostate and the lipid phosphatase Pten, which regulates cell growth and is highly associated with the development of human prostate cancer. The first two years of funding were highly productive and resulted in one manuscript publication supporting a functional collaboration between p18Ink4c and ... |
|
| Inhibitors for Androgen Receptor Activation Surfaces |
SEP 2006 |
45 pages |
| Authors:
Robert J. Fletterick; CALIFORNIA UNIV SAN FRANCISCO
|
| The androgen receptor (AR) is a proven therapeutic target for treating prostate cancer. Known therapeutics target the ligand binding domain (LBD) at the exact place where dihydrotestosterone (DHT) binds. Upon binding DHT, AR reorganizes to form new interaction surfaces such as the AF2 surface that attracts coregulators. AF2 has been proposed as a second therapeutic target as coactivator recruitment is a key step for AR function. We developed two screening ... |
|
| The Calcium Channel CaT1 in Prostate Cancer Progression |
JAN 2006 |
11 pages |
| Authors:
Michael R. Freeman; CHILDREN'S HOSPITAL CORP BOSTON MA
|
| This project focuses on the potential role of the calcium-selective ion channel, CaT1, in prostate cancer progression. Although the physiological role of CaT1 is still poorly understood, it may be a store-operated" calcium pore, a type of channel that is known to play a role in cell growth and survival regulation. The Aims of this project are to (1) Develop specific antibodies against CaT1 and characterize its expression pattern(s) in ... |
|
| Definition of the Molecular Mechanisms Which Distinguish Between Selective Estrogen Receptor Modulators (SERMs) and Full Antiestrogens |
14 SEP 2005 |
15 pages |
| Authors:
Huey-Jing Huang; DUKE UNIV MEDICAL CENTER DURHAM NC
|
| Tamoxifen, a SERM (Selective Estrogen Receptor Modulator), is the most commonly used endocrine treatment for all stages of breast cancer. However, progression from tamoxifen sensitivity to tamoxifen resistance occurs in a substantial portion of the tumors. Full antiestrogens, such as ICI 182,7&0, are currently used as the second line therapy after-failure of long-term tamoxifen therapy. To facilitate the design and characterization of more appropriate therapeutic agents for endocrine therapy of ... |
|
| Optical Coherence Tomography of the Breast: A Feasibility Study |
MAY 2005 |
11 pages |
| Authors:
James L. Connolly; BETH ISRAEL DEACONESS MEDICAL CENTER BOSTON MA
|
| Optical Coherence Tomography (OCT) is an emerging high-resolution imaging technology that can perform high resolution, real-time cross-sectional imaging of tissue. OCT can be used as a type of "optical biopsy to perform minimally-invasive imaging up to a depth of 2-3 mm with transverse resolutions as high as 10 um in commercially available systems. OCT uses near-infrared light which can be used in fiber optic devices such as catheter probes and ... |
|
| Amplification of Anti-Tumor Immunity Without Antoimmune Complications |
MAY 2005 |
10 pages |
| Authors:
Wei-Zen Wei; WAYNE STATE UNIV DETROIT MI
|
| The hypothesis is that inactivation of Treg cells accompanied by Neu DNA vaccination will overcome tolerance in BALB NeuT mice and inhibit spontaneous matnmarytunorigenesis or reject an established s.c. tumor. The anticipated tumor growth inhibition maybe achieved at the risk of developing autoimmunity. Thyroiditis will be measured to indicate the level of risk. We further hypothesize that DNA vaccines encoding both Neu and GlTRligand will stimulate effectorT cells via conventional ... |
|
| Suppression of Prostate Cancer by PTEN and p18(INK4C) |
FEB 2005 |
16 pages |
| Authors:
Feng Bai; NORTH CAROLINA UNIV AT CHAPEL HILL
|
| The Rb pathway suppresses tumorigenesis by constraining G1 cell cycle progression. Functional inactivation or reduction of this pathway is a common event found in many types of human tumors. To test how the Rb pathway interacts with other cellular pathways in tumor suppression, we characterized mice with combined mutations in the CDK inhibitor p18 (sub Ink4c) and the lipid phosphatase Pten, which regulates cell growth and survival. Thep18-/-;Pten +/-double mutant ... |
|
| Medical Managment of the Acute Radiation Syndrome: Recommendations of the Strategic National Stockpile Radiation Working Group |
15 JUN 2004 |
20 pages |
| Authors:
Jamie K. Waselenka; Thomas J. MacVittie; William F. Blakely; Nicki Pesik; Albert L. Wiley; William E. Dickerson; Horace Tsu; Dennis L. Confer; Norman Coleman; Thomas Seed; ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD
|
| Physicians, hospitals, and other health care facilities will assume the responsibility for aiding individuals injured by a terrorist act involving radioactive material. Scenarios have been developed for such acts that include a range of exposures resulting in few to many casualties. This consensus document was developed by the Strategic National Stockpile Radiation Working Group to provide a framework for physicians in internal medicine and the medical subspecialties to evaluate and ... |
|
| Characterization of Novel Genes With 8p11-12 Amplicon in Breast Cancer |
JUN 2004 |
29 pages |
| Authors:
Zeng-Quan Yang; MICHIGAN UNIV ANN ARBOR
|
| Gene amplification plays an important role in tumorigenesis of human neoplasia, including breast cancer. Oncogenes, such as ERBB2 , CCND1 and C-MYC have already been identified as amplification targets associated with development, progression, or metastasis of breast cancer(1-4). However there are several amplified regions where target genes have yet to be characterized. One of these is the 8p11-p12 region, which has been shown to be amplified in about 10-15% of ... |
|
| DOD Operational Ranges: More Reliable Cleanup Cost Estimates and a Proactive Approach to Identifying Contamination Are Needed |
MAY 2004 |
55 pages |
| Authors:
GENERAL ACCOUNTING OFFICE WASHINGTON DC
|
| For decades, the Department of Defense (DOD) has tested and fired munitions on millions of acres of operational ranges. These munitions contain various constituents such as lead, trinitrotoluene (TNT), and ammonium perchlorate salt (perchlorate) that are, in some instances, known or suspected of causing health effects such as damage to the central and peripheral nervous systems, cancer, and interfering with thyroid function. Concerns about the potential cost to clean up ... |
|
| Field Screening Method for Perchlorate in Water and Soil |
APR 2004 |
36 pages |
| Authors:
Philip G. Thorne; ENGINEER RESEARCH AND DEVELOPMENT CENTER HANOVER NH COLD REGIONS RESEARCH AND ENGINEERING LAB
|
| Low concennations (microgram/L of the perchlorate anion ClO4 have been measured in drinking water supplies in many states throughout the United States. Federal and state regulatory agencies are concerned about the possible adverse effects of perchlorate contamination as the anion is known to target the human thyroid gland and its metabolic-hormone-producing function. The provisional aenon level for drinking water established by the EPA and adopted by several states is 18 ... |
|
| The Calcium Channel CaT1 in Prostate Cancer Progression |
JAN 2004 |
40 pages |
| Authors:
Michael R. Freeman; CHILDREN'S HOSPITAL CORP BOSTON MA
|
| This project focuses on the potential role of the calcium-selective ion channel, CaTl, in prostate cancer progression. Although the physiological role of CaTl is still poorly understood, it may be a "store-operated" calcium pore, a type of channel that is known to play a role in cell growth and survival regulation. The Aims of this project are to (1) Develop specific antibodies against CaTl and characterize its expression pattern(s) in ... |
|
| Optical Coherence Tomography of the Breast: A Feasibility Study |
OCT 2003 |
11 pages |
| Authors:
James L. Connolly; Liron Pantanowitz; Paul Herz; Pei-Lin Hsiung; Sughra Raze; BETH ISRAEL DEACONESS MEDICAL CENTER BOSTON MA
|
| Optical Coherence Tomography (OCT) is an emerging high-resolution imaging technology that can perform high resolution, real-time cross-sectional imaging of tissue. OCT can be used as a type of "optical biopsy" to perform minimally-invasive imaging up to a depth of 2-3 mm with transverse resolutions as high as 10 um in commercially available systems. OCT uses near-infrared light which can be used in fiber optic devices such as catheter probes and ... |
|
| A Novel Phosphatase Gene on 10q23, MINPP, in Hereditary and Sporadic Breast Cancer |
AUG 2003 |
49 pages |
| Authors:
Charis Eng; OHIO STATE UNIV RESEARCH FOUNDATION COLUMBUS
|
| PTEN is a tumor suppressor gene on 10q23 and encodes a dual specificity phosphatase. One of the major substrates for PTEN is phosphotidylinositol (3,4,5) triphosphate in the P13 kinase pathway. When PTEN is dysfunctional or absent, P-Akt is high and hence, anti-apoptotic. PTEN is a major susceptibility gene for Cowden syndrome (CS), a hereditary disorder with a high risk of breast and thyroid cancer, and appears to be involved in ... |
|
| Definition of the Molecular Mechanisms Which Distinguish Between Selective Estrogen Receptor Modulators (SERMs) and Full Antiestrogens |
MAY 2003 |
12 pages |
| Authors:
Huey-Jing Huang; DUKE UNIV MEDICAL CENTER DURHAM NC
|
| Tamoxifen, a SERM (Selective Estrogen Receptor Modulator), is the most commonly used endocrine treatment for all stages of breast cancer. However, progression from tamoxifen sensitivity to tamoxifen resistance occurs in a substantial portion of the tumors. Full antiestrogens, such as ICI 182,780, are currently used as the second line therapy after failure of long-term tamoxifen therapy. To facilitate the design and characterization of more appropriate therapeutic agents for endocrine therapy ... |
|
| The Calcium Channel CaT1 in Prostate Cancer Progression |
JAN 2003 |
18 pages |
| Authors:
Micahel R. Freeman; CHILDREN'S HOSPITAL MEDICAL CENTER BOSTON MA
|
| This project focuses on the potential role of the calcium-selective ion channel, CaT1, in prostate cancer progression. Although the physiological role of CaT1 is still poorly understood, it may be a "store-operated" calcium pore, a type of channel that is known to play a role in cell growth and survival regulation. The Aims of this project are to (1) Develop specific antibodies against CaT1 and characterize its expression pattern(s) in ... |
|
| Advanced Cancer Detection Center |
OCT 2002 |
51 pages |
| Authors:
Jeffrey P. Krischer; UNIVERSITY OF SOUTH FLORIDA TAMPA
|
| The goals of the Advanced Cancer Detection Center include the discovery of molecular and genetic markers of cancer risk, the identification of individuals at high risk for cancer through screening and the testing of methods to prevent cancer. The projects included in this report are: 1) Markers of Transformation in Airways Epithelial Cells from a Cohort of Obstructed Smokers and Former Smokers (PI: Tockman); 2) Development of the Moffitt Cancer ... |
|
| Accession Medical Standards Analysis and Research Activity Annual Report 2001 |
01 AUG 2002 |
103 pages |
| Authors:
David W. Niebuhr; Yuanzhang Li; Timothy B. Powers; Margot R. Krauss; WALTER REED ARMY INST OF RESEARCH SILVER SPRING MD DEPT OF EPIDEMIOLOGY/ DIV OF PREVENTITIVE MEDICINE
|
| The Accession Medical Standards Analysis and Research Activity annual Report 2001 summarizes work done to support the development of evidence-based medical accession standards contained in DoD Instruction 6130.4 "Criteria and Procedure Requirements for Physical Standards for Appointment, Enlistment, or Induction in the Armed Forces." Studies in this report include: 1. Retention of Mild Asthmatics in the Navy, 2. Early Attrition Caused by Asthma in 2001 at FT Jackson, 3. Early ... |
|
| A Novel Phosphatase Gene on 10q23, MINNP, in Hereditary and Sporadic Breast Cancer |
AUG 2002 |
28 pages |
| Authors:
Charis Eng; OHIO STATE UNIV RESEARCH FOUNDATION COLUMBUS
|
| PTEN is a tumor suppressor gene on 10q23 and encodes a dual specificity phosphatase. One of the major substrates for PTEN is phosphotidylinositol (3,4,5) triphosphate in the PI3 kinase pathway. When PTEN is dysfunctional or absent, P-Akt is high and hence, anti-apoptotic. PTEN is a major susceptibility gene for Cowden syndrome (CS), a hereditary disorder with a high risk of breast and thyroid cancer, and appears to be involved in ... |
|
| Orphan Receptor TR3/nur77 and Apoptosis in Prostate Cancer Cells |
JUL 2002 |
35 pages |
| Authors:
Xiao-kun Zhang; BURNHAM INST LA JOLLA CA
|
| A class of new synthetic retinoids related to 6-3-(L-ADAMANTYL)-4- HYDROXYPHENYL-2- naphthalene carboxylic acid (AHPN/CD437) effectively induce apoptosis of prostate cancer cells. Our previous study demonstrated that AHPN/ CD437-induced apoptosis of LNCaP prostate cancer cells requires the expression of TR3 (also called nur77 or NGFI-B) that is an orphan member of the steroid/ thyroid/retinoid receptor superfamily and its nuclear export and mitochondrial localization. In studying how TR3 nuclear export, mitochondrial targeting ... |
|
| Regulation to I Transport in Breast Cancer Cell Lines |
JUN 2002 |
33 pages |
| Authors:
Claudia Riedel; Nancy Carrasco; ALBERT EINSTEIN COLL OF MEDICINE OF (YESHIVA UNIV) BRONX NY
|
| Like thyroid tissue, lactating breast actively accumulates iodide via the Na+/I- symporter (NIS). Iodide is thus supplied to the nursing newborn in the milk. Iodide transport via NIS has been used successfully for over 60 years to treat thyroid cancer by administration of radioiodide. We have shown that over 80% of human breast cancers express NIS, raising the possibility that radioiodide may be used for diagnosis and treatment of breast ... |
|
| Temporal and Frequency Analysis of Click-Evoked Otoacoustic Emissions Recorded from Untreated Congenital Hypothyroid Newborns |
25 OCT 2001 |
|
| Authors:
M. Parazzini; P. Ravazzani; S. Medaglini; G. Weber; G. Tognola; POLITECNICO DI MILANO (ITALY) BIOMEDICAL ENGINEERING
|
 | Thyroid hormone plays an important role in hearing development. The exact incidence of hearing impairment in untreated congenital hypothyroid newborns (CH) is unknown. This paper presents the results of the measuring of the transient-evoked otoacoustic emissions (TEOAE) on a population of 29 newborns positive to the screening test for hypothyroidism. TEOAE were recorded in all newborns in 1 month after birth and before starting the L-thyroxin treatment We performed both ... |
|
| Advanced Cancer Detection Center |
OCT 2001 |
195 pages |
| Authors:
Jeffrey P. Krischer; John C. Ruckdeschel; Rebecca Sutphen; Nagi Kumar; Melvyn Tockman; UNIVERSITY OF SOUTH FLORIDA TAMPA
|
| The goals of the Advanced Cancer Detection Center include the discovery of molecular end genetic markers of cancer risk, the identification of individuals at high risk for cancer through screening and the testing of methods to prevent cancer. The projects included in this report are: (1) Markers of Transformation in Airways Bpithelial Cells from a Cohort of Obstructed Smokers and Former Smokers (PT: Tockman); (2) The Specific Role of Isoflavones ... |
|
| LRMC Remote Teleretinology and Teleopthamology Project |
OCT 2001 |
8 pages |
| Authors:
Erik Kobylarz; LANDSTUHL REGIONAL ARMY MEDICAL CENTERAPO NEW YORK 09180
|
| Clinical-Diagnostic: The time to diagnosis has certainly been reduced through the use of this imaging system. We have immediate results of the fluoroscein angiogram studies we perform as well as instant digital photographs we can temporally compare with those taken previously to assess and monitor the patients' ophthalmologic disease processes. The above benefit has certainly helped expedite the appropriate administration of care to our patients. |
|
| Genetics of PTEN in Cowden Syndrome and Sporadic Breast Cancer |
OCT 2001 |
66 pages |
| Authors:
Charis Eng; OHIO STATE UNIV RESEARCH FOUNDATION COLUMBUS
|
| Germline mutations in PTEN on 10q23.3 cause 80% of classic Cowden syndrome (CS) and SO of Bannayan-Riley-Ruvalcaba syndrome (CS) as well as up to 20% of Proteus syndrome and up to 50 of unclassified Proteus-like syndromes. The major thrust of this grant was to identify and characterize PTEN's involvement in families and individuals with one ore more CS component tumors, of which prominently is breast cancer. During the funding period, ... |
|
| Weight Gain in Breast Cancer Patients on Chemotherapy: Exploring Hormonal, Body Composition and Behavior Mechanisms |
SEP 2001 |
19 pages |
| Authors:
Nagi B. Kumar; UNIVERSITY OF SOUTH FLORIDA TAMPA
|
| The purpose of the study is to observe the relative contribution of thyroid function, sex-hormonal levels, physical activity, psychological state and nutritional intake on changes in body weight in a group of breast cancer patients, receiving adjuvant chemotherapy. Based on the preliminary observations, weight gain in breast cancer patients may be a phenomenon resulting from hormonal and lifestyle changes and offers an opportunity for prevention and improved prognosis. |
|
| A Novel Phosphatase Gene on 10q23, MINPP, in Hereditary and Sporadic Breast Cancer |
AUG 2001 |
19 pages |
| Authors:
Charis Eng; OHIO STATE UNIV COLUMBUS
|
| PTEN is a tumor suppressor gene on 10q23 and encodes a dual specificity phosphatase. One of the major substrates for PTEN is phosphotidylinositol (3,4,5) triphosphate in the PI3 kinase pathway. When PTEN is dysfunctional or absent, P-Akt is high and hence, anti-apoptotic. PTEN is a major susceptibility gene for Cowden syndrome (CS), a hereditary disorder with a high risk of breast and thyroid cancer, and appears to be involved in ... |
|
| Advanced Cancer Detection Center |
OCT 2000 |
145 pages |
| Authors:
John Ruckdeschel; Jeffrey P. Krischner; Rebecca Sutphen; Nagi Kumar; Melvyn Tockman; UNIVERSITY OF SOUTH FLORIDA TAMPA
|
| The goals of the Advanced Cancer Detection Center include the discovery of molecular and genetic markers of cancer risk, the identification of individuals at high risk for cancer through screening, and the testing of methods to prevent cancer. |
|
| Genetics of PTEN in Cowden Syndrome and Sporadic Breast Cancer |
OCT 2000 |
76 pages |
| Authors:
Charis E. Eng; OHIO STATE UNIV COLUMBUS
|
| Germilne mutations in PTEN, a tumor suppressor gene located on 10q23. 3, is associated with 80% of Cowden syndrome (CS) probands ascertained by the strict operational diagnostic criteria of the International Cowden Consortium. CS is an inherited multiple hamartoma syndrome with a high risk of breast and thyroid cancer. The PT has found that 5% of unselected apparently sporadic breast cancer patients diagnosed under the age of 40 carry occult ... |
|
| Involvement of Nuclear Receptor Co-repressors in the Development of Human Breast Cancers |
SEP 2000 |
116 pages |
| Authors:
J. D. Chen; MASSACHUSETTS UNIV MEDICAL CENTER WORCESTER
|
| All-trans retinoic acids (RA) inhibits proliferation of breast cancer cells. This effect is presumably mediated by the retinoic acid receptors (RAR) . In the absence of RA, the RAR represses basal transcription through interaction with nuclear receptor corepressors such as SMRT (silencing mediator for retinoid and thyroid receptors) or N-CoR (nuclear receptor corepressor) . In this project, we have characterized receptor interaction and transcriptional repression function of SMRT and N-CoR. ... |
|
| A Neurodevelopmental Study of the Effects of Oral Ammonium Perchlorate Exposure on the Motor Activity of Pre-Weanling Rat Pups |
26 JUN 2000 |
|
| Authors:
Marni Y. Bekkedall; Tonya Carpenter; Julie Smith; Cynthia Ademujohn; Debra Maken; NAVAL HEALTH RESEARCH CENTER WRIGHT-PATTERSON AFB OH TOXICOLOGY DETACHMENT
|
| The objective was to assess the neurotoxicity of ammonium perchlorate as it relates to the development of the motor system. Ammonium perchlorate is used in solid rocket propellant systems, and has been found in ground water at sites where this propellant is manufactured and stored. It readily dissociates in water and produces perchlorate ion that displaces the iodide (I-) anion and disrupts thyroid activity. The thyroid ... |
|
| LRMC Remote Teleretinology and Teleopthalmology Project |
MAY 2000 |
4 pages |
| Authors:
Erik Kobylarz; LANDSTUHL REGIONAL ARMY MEDICAL CENTERAPO NEW YORK 09180
|
| The Topcon digital ocular fundus and fluoroscein angiogram digital imaging system, which was purchased with the allotted P8 funding, has been of great use in the LRMC ophthalmology and neuro-ophthalmology clinic for patients referred from throughout ERMC. The metrics for this machine's use are shown below: 1. Since 28 July 00, when the camera was finally installed in our clinic, we have taken high resolution digital ophthalmologic photographs of 64 ... |
|
| Genetics of PTEN in Cowden Syndrome and Sporadic Breast Cancer |
OCT 1999 |
54 pages |
| Authors:
Charis Eng; OHIO STATE UNIV RESEARCH FOUNDATION COLUMBUS
|
| Cowden syndrome (CS) is an autosomal dominant disorder characterized by multiple hamartomas and a high risk of breast, thyroid and other cancers. The susceptibility gene is PTEN. The edict of this grant is to determine the genetic role of PTEN in non-CS CS-like families or individuals. The PI has accrued 15 site specific breast cancer families, without known BRCA1 and BRCA2 mutations. No intragenic PTEN mutations were ... |
|
| Mechanism of Thyroid Hormone-Induced Osteoporosis |
OCT 1999 |
55 pages |
| Authors:
Paula H. Stern; NORTHWESTERN UNIV EVANSTON IL
|
| Thyroid hormone (T3) is essential for normal skeletal growth and development. Excess T3, especially in adult individuals, can lead to bone loss and increased susceptibility to fractures. Data from our laboratory showed that in vitro systems, T3 increases the local production of both a critical bone growth factor, insulin-like growth factor-I. It also potentiated interleukin-1 (IL-1) stimulated production of a cytokine with significant importance for osteoclastogenesis, interleukin-6 (IL-6). The current ... |
|
| Involvement of Nuclear Receptor Co-repressors in the Development of Human Breast Cancers |
SEP 1999 |
106 pages |
| Authors:
J. D. Chen; MASSACHUSETTS UNIV MEDICAL CENTER WORCESTER
|
| All-trans retinoic acid (RA) inhibits proliferation of breast cancer cells, mediated by its nuclear receptor (RAR). In the absence of RA, the RAR represses basal transcription through direct interaction with SMRT (silencing mediator for retinoid and thyroid receptors) or N-CoR (nuclear receptor corepressor). In this project, we characterized receptor interaction and transcriptional repression mediated by SMRT and N-CoR. We investigated the expression and regulation ... |
|
| Weight Gain in Breast Cancer Patients on Chemotheraphy: Exploring Hormonal Body Composition and Behavioral Mechanisms |
SEP 1999 |
10 pages |
| Authors:
Nagi B. Kumar; UNIVERSITY OF SOUTH FLORIDA TAMPA
|
| Purpose: The purpose of this study is to prospectively and systematically observe the relative contribution of each viable mechanism such as nutritional intake, activity levels, body composition, hormonal function, thyroid function, coping mechanisms and fatigue scores during chemotherapy on weight gain in breast cancer patients. If changes in the above factors contribute to weight gain and thus alter prognosis, manipulation of these variables by timely intervention may improve prognosis and ... |
|
| Ret Receptor: Functional Consequences of Oncogenic Rearrangements |
OCT 1998 |
44 pages |
| Authors:
Susan S. Taylor; CALIFORNIA UNIV SAN DIEGO LA JOLLA
|
| The ret/ptc2 gene was cloned from human papillary thyroid carcinomas, and is the product of a reciprocal chromosomal rearrangement, translocation event between the cAMP dependent protein kinase regulatory subunit I alpha (RI alpha) and the tyrosine kinase domain of the Ret receptor. Ret/ptc2 is a dimer which is autophosphorylated, soluble, and constitutively active. We generated a computer model of the Ret/ptc2 kinase domain, expressed and purified Ret/ptc2, developed a kinase ... |
|
| Mechanism of Thyroid Hormone-Induced Osteoporosis |
OCT 1997 |
29 pages |
| Authors:
Paula H. Stern; NORTHWESTERN UNIV EVANSTON IL
|
| The goal of the research is to determine the mechanism by which thyroid hormone (T3) affects bone, and the cause of the osteoporosis that can result when T3 concentrations are excessive. Our previous publications had shown that T3 increases the production of the bone growth factor insulin-like growth factor-I (IGF-I) in osteoblastic cells and promotes the production of the osteoclastogenic cytokine interleukin-6. The experiments carried out ... |
|
| Ret Receptor: Functional Consequences of Oncogenic Rearrangements |
OCT 1997 |
27 pages |
| Authors:
Susan S. Taylor; CALIFORNIA UNIV SAN DIEGO LA JOLLA
|
| Ret/ptc2 is a soluble, constitutively active oncogenic protein whose gene was cloned from human papillary thyroid carcinomas. Ret/ptc2 is a chimeric protein resulting from a reciprocal chromosomal rearrangement translocation event between the cAMP-dependent protein kinase regulatory subunit type Ialpha (RIalpha) and the tyrosine kinase domain of the Ret receptor. Earlier microinjection studies showed the RIalpha dimerization domain is critical for eliciting a mitogenic ... |
|
| Ret Receptor: Functional Consequences of Oncogenic Rearrangements |
OCT 1996 |
44 pages |
| Authors:
Susan S. Taylor; CALIFORNIA UNIV SAN DIEGO LA JOLLA
|
| Ret/ptc2 is a soluble, constitutively active oncogene isolated from human papillary thyroid carcinomas. Sequence analysis of ret/ptc2 indicated that the gene resulted from a reciprocal rearrangement event between the cAMP- dependent protein kinase regulatory subunit Ialpha (RIalpha) and the entire tyrosine kinase domain of the Ret receptor. Using the crystal structure of the insulin receptor tyrosine kinase, we have obtained a working model of the Ret/ ptc2 kinase domain. This ... |
|
| Effects of Ammonium Perchlorate on the Thyroid Hormone Levels of the Sprague-Dawley Rat |
DEC 95 |
69 pages |
| Authors:
James H. King Jr; AIR FORCE INST OF TECH WRIGHT-PATTERSON AFB OH SCHOOL OF ENGINEERING
|
| The purpose of this research was to determine the threshold dose for ammonium perchlorate (AP) in the Sprague-Dawley rat. No dose response data exist for AP and the EPA has studied literature on the subject of perchlorates to determine a provisional reference dose. The Perchiorate Group, a consortium of DoD and industry representatives, believes this provisional reference dose is too conservative. This experiment was executed to provide dose response data ... |
|
| An Epidemiologic Investigation of Health Effects in Air Force Personnel Following Exposure to Herbicides. Volume 2. |
02 MAY 1995 |
440 pages |
| Authors:
William D. Grubbe; William H. Wolfe; Joe E. Michalek; David E. Williams; Michael B. Lustik; SCIENCE APPLICATIONS INTERNATIONAL CORP MCLEAN VA
|
| Despite conclusive evidence that chiorophenols are potent carcinogens in laboratory animals, the carcinogenicity of dioxin in humans remains controversial. Traditional difficulties in extrapolating animal data to humans have limited the applicability and relevance of much of the experimental work. Numerous long-term exposure studies have established the carcinogenicity of 2,3, 7,8- tetrachlorodibenzo-p-dioxin (TCDD, or dioxin) in rats (1,2), mice (3-5), and hamsters (6). The consensus of most research is that TCDD ... |
|
| Clinical Investigation Program Annual Progress Report |
30 SEP 93 |
524 pages |
| Authors:
Kenneth E. Sherman; FITZSIMONS ARMY MEDICAL CENTER AURORA CO
|
| Subject report identifies these individual who are conducting investigative protocols at Fitzsimons Army Medical. An abstract of each protocol giving abbreviated technical approach, objectives, and progress is presented. |
|
| Relationship Between Changes in Serum Thyrotropin and Total and Lipoprotein Cholesterol with Prolonged Antarctic Residence |
SEP 1993 |
7 pages |
| Authors:
R. R. Harford; H. L. Reed; M. T. Morris; I. E. Sapien; R. Warden; NAVAL MEDICAL RESEARCH INST BETHESDA MD
|
| Antarctic residence (AR) is associated with a 50% increase in the thyrotropin (TSH) response to TSH-releasing hormone (TRH) and an expended triiodothyronine (T3) distribution volume and extravascular hormone pool, collectively called the polar T3 syndrome. To investigate the possible biologic significance of this syndrome, we studied the relationship between nonstimulated TSH and serum lipid profiles in nine subjects, once while in California and monthly during 9 months of AR. We ... |
|
| Toxicology of Perfluorodecanoic Acid |
01 NOV 90 |
|
| Authors:
Richard E. Peterson; WISCONSIN UNIV-MADISON SCHOOL OF PHARMACY
|
| Despite hypothyroxinemia, PFDA-treated rats are not functionally hypothyroid. Furthermore, any alteration in functional thyroid status can be dissociated from the overt toxicity (i.e., severe hypophagia and body weight loss). PFDA exerts effects on neutral lipid metabolism in both liver and carcass of the rat. At 7 days following a single administration of PFDA, hepatic esterification of free fatty acid into TG and CE was increased yet the expected augmentation in ... |
|
| Cachectin/Tumor Necrosis Factor and the Pituitary-Adrenal Axis |
28 FEB 90 |
|
| Authors:
Diana S. Malcolm; UNIFORMED SERVICES UNIV OF THE HEALTH SCIENCES BETHESDA MD DEPT OF SURGERY
|
| Results from our studies investigating immune-neuroendocrine interactions have yielded interesting and novel findings. In unanesthetized rats, TNF (10ug/kg) was a potent stimulus for ACTH release without affecting hemodynamics. In vitro, TNF was without effect on the basal secretion of corticosterone (CS) but inhibited ACTH-stimulated CS release. Likewise, TNF inhibited TSH-stimulated thyroglobulin release from cultured human thyroid cells. In vitro, ACTH tended to inhibit LPS-induced TNF release from cultured macrophages, however, ... |
|
| Cachectin/Tumor Necrosis Factor and the Pituitary-Adrenal Axis |
06 APR 89 |
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| Authors:
Diana S. Malcom; Merrily Poth; UNIFORMED SERVICES UNIV OF THE HEALTH SCIENCES BETHESDA MD
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| Preliminary studies investigating immune-neuroendocrine interactions have yielded several interesting and novel findings. Intravenous injections of low doses of TNF (0.01-0.10 mg/kg) in unanesthetized animals resulted in significant elevations in circulating ACTH and corticosterone. These low doses of TNF did not produce changes in mean pressure but did increase heart rate within 5-10 minutes post-injection. In vitro, TNF was shown to inhibit ACTH- stimulated corticosterone adrenal cells. Similarly, TNF inhibited TSH-stimulated ... |
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| Thyroid and Biochemical/Metabolic Effects of PFDA (Perfluoro-n-decanoic Acid) |
04 JAN 88 |
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| Authors:
Albert E. Langley; WRIGHT STATE UNIV DAYTON OH DEPT OF PHARMACOLOGY
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| Significantly greater weight loss was observed in PFDA-treated rats than in pair controlled rats. These data indicate that the wasting syndrome cannot be explained entirely by lack of food intake. Additionally, a precipitous fall in serum thyroxine was observed as early as 12 hours following PFDA. Early experiments indicated that a hypothyroid-like state resulted from PFDA treatment. PFDA induced decreases in serum thyroid hormones, anorexia, bradycardia, hypothermia, as well as ... |
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Reports by Keyword(s)
THYROID GLAND
