| Modifiable Risk Factors for Lymphedema in Breast Cancer Survivors |
OCT 2007 |
26 pages |
| Authors:
Mary A. Rossing; Kathleen E. Malone; FRED HUTCHINSON CANCER RESEARCH CENTER SEATTLE WA
|
 | In this study, 433 women with invasive breast cancer who had >5 axillary lymph nodes removed were followed for the development of arm lymphedema. Participants completed a baseline interview and subsequent interviews at 6-9 month intervals. Lymphedema was identified through self-report and through measurement of arm volume. Slightly more than half of participants reported arm swelling (n=228; 52.7%). Measured arm volume excess of >10% comparing the surgery-side to the opposite ... |
|
| High-Throughput Screening of Compounds for Anti-Transmissible Spongiform Encephalopathy Activity Using Cell-Culture and Cell-Free Models and Infected Animals |
JUL 2007 |
33 pages |
| Authors:
Byron Caughey; David Kocisko; NATIONAL INSTITUTES OF HEALTH HAMILTON MT ROCKY MOUNTAIN LABS
|
| No effective treatments have been validated for the transmissible spongiform encephalopathies (TSEs) or prion diseases. To advance the rational basis for the search for anti-TSE therapeutics, we have developed a new unified mechanistic model for the activity of various classes of PrPSc inhibitors which is consistent with a considerable body of evidence from our laboratory and others. Based on this model, we have successfully developed a new potentially high-throughput screen ... |
|
| Molecular Targeting of the PI3K/Akt Pathway to Prevent the Development of Hormone Resistant Prostate Cancer |
FEB 2007 |
5 pages |
| Authors:
Jonathan Walker; ARIZONA UNIV TUCSON
|
| Recently, the PI3K/Akt pathway has been found to be a significant factor in the development and progression of prostate cancer. It is the authors' belief that the PI3K/Akt pathway is the critical pathway that is maintaining survival by blocking apoptosis in the absence of hormonal stimulation. They will use molecular targeting to inhibit the phosphorylation of Akt. Celecoxib is a FDA approved COX-2 inhibitor. What is unique to celecoxib is ... |
|
| Analysis of Morphogenic Effect of hDAB2IP on Prostate Cancer and its Disease Correlation |
FEB 2007 |
22 pages |
| Authors:
Jer-Tsong Hsieh; TEXAS UNIV AT DALLAS SOUTHWESTERN MEDICAL CENTER
|
| Imbalance of apoptotic and/or survival signaling cascade is a hallmark of malignant cell. In prostate cancer (PCa), constitutive activation of phosphatidylinositol 3-kinase (PI3K)-Akt/PKB and inactivation of apoptosis-stimulated kinase (ASK1)-JNK pathway signaling are often detected in metastatic cell. Understanding the underlying mechanism leading to such alternations will provide a better treatment strategy to control the terminal stage of this disease. In this project, we have proposed that DAB2IP protein, a novel ... |
|
| The Victims of Terrorism: An Assessment of Their Influence and Growing Role in Policy, Legislation, and the Private Sector |
2007 |
|
| Authors:
Bruce Hoffman; Anna-Britt Kasupski; RAND CORP SANTA MONICA CA
|
 | Little attention and analysis have focused on terrorism victims, including survivors. This report focuses on the organized groups of families and friends that have emerged since September 11, 2001, to become a powerful voice in U.S. counterterrorism policy and legislation. These groups were remarkably successful in getting the 9/11 Commission established as well as the enactment of the commission's most important recommendations. This report documents these groups' number and diversity, ... |
|
| Duration of Protection of Rabbits after Vaccination with Bacillus anthracis Recombinant Protective Antigen Vaccine |
27 DEC 2005 |
8 pages |
| Authors:
S. F. Little; B. E. Ivins; W. M. Webster; P. F. Fellows; M. L. Pitt; S. L. Norris; G. P. Andrews; ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD
|
| Long-term protection of rabbits that had been vaccinated with two doses of a recombinant protective antigen (rPA) vaccine was examined against an aerosol spore challenge with the Ames isolate of Bacillus anthracis at 6 and 12 months. At 6 months after the primary injection, survival was 74.1% (20/27) with quantitative ELISA titer of 22.3mug of anti-rPA IgG per millilitre and toxin neutralizing antibody (TNA) assay titer of 332. At 12 ... |
|
| Mechanism of FADD-DN-Induced Apoptosis in Normal Breast Cells |
14 SEP 2005 |
7 pages |
| Authors:
Lance R. Thomas; WAKE FOREST UNIV WINSTON-SALEM NC SCHOOL OF MEDICINE
|
| Normal cells undergo apoptosis in response to inappropriate growth signals or the lack of overt survival signals. Tumor cells possess defects in apoptosis regulatory pathways and do not undergo apoptosis in these situations. Because FADD is an essential component of receptor mediated apoptosis, a dominant-negative version (FADD-DN) is able to block apoptosis induced by death ligands in many cell lines. While studying FADD signaling, our laboratory made the surprising discovery ... |
|
| Estrogen and Retinoid Regulation of DNA Repair in Breast Cancer |
MAY 2005 |
15 pages |
| Authors:
David L. Crowe; UNIVERSITY OF SOUTHERN CALIFORNIA LOS ANGELES
|
| BRCA1 is involved in repair of double strand breaks induced by ionizing radiation and chemotherapy drugs. BRCA1 and nuclear hormone receptors interact with p3OO and CREB binding protein (CBP) to activate target gene transcription. Few studies have suggested a role for nuclear hormone receptors in DNA repair. E2 and RA had opposing effects on DNA damage and breast cancer cell survival following double strand break damage. Estradiol but not retinoic ... |
|
| Rescuing High Avidity T Cells for Prostate Cancer Immunotherapy |
APR 2005 |
66 pages |
| Authors:
Pan Zheng; OHIO STATE UNIV RESEARCH FOUNDATION COLUMBUS
|
| This is the second annual report on the grant "Rescuing high avidity T cells for prostate cancer immunotherapy". The purpose of the grant proposal is to rescuing high avidity tumor-antigen specific T cells that can respond effectively to prostate cancer cells and delay the delay the development of prostate cancer in the TRAMP mouse model. The innovative idea is based on the hypothesis that blockade of the T cell costimulatory ... |
|
| Suppression of Prostate Cancer by PTEN and p18(INK4C) |
FEB 2005 |
16 pages |
| Authors:
Feng Bai; NORTH CAROLINA UNIV AT CHAPEL HILL
|
| The Rb pathway suppresses tumorigenesis by constraining G1 cell cycle progression. Functional inactivation or reduction of this pathway is a common event found in many types of human tumors. To test how the Rb pathway interacts with other cellular pathways in tumor suppression, we characterized mice with combined mutations in the CDK inhibitor p18 (sub Ink4c) and the lipid phosphatase Pten, which regulates cell growth and survival. Thep18-/-;Pten +/-double mutant ... |
|
| Methylselenium and Prostate Cancer Apoptosis |
FEB 2005 |
15 pages |
| Authors:
Junxuan Lu; MINNESOTA UNIV MINNEAPOLIS
|
| The purpose of this research is to gain a better understanding of the biochemical pathways and molecular targets for the selective induction of apoptosis signaling and execution of prostate cancer (PCa) cells by methyl selenium (Se)/selenol. We hypothesized that methyl selenium inhibits survival pathway leading to the activation of caspase-dependent apoptosis execution in PCa cells. The specific aims are to delineate the caspase-mediated execution pathways of apoptosis (Objective 1) and ... |
|
| Hormone Receptors in Breast Cancer Prognosis - Racial and Quantitative Effects |
DEC 2004 |
48 pages |
| Authors:
Carl M. Tammemagi; HENRY FORD HEALTH SYSTEM DETROIT MI
|
| The study purpose was to develop an understanding of race/ethnic disparities in breast cancer survival, with an emphasis on hormone receptor differences. A cohort of 924 breast cancer patients was followed (median 10.0 years). Clinicopathologic and survival data were abstracted from medical records and our institutional and SEER Tumor Registries. Detailed comorbidity data was gathered. Breast cancer estrogen receptor (ER) status measured in the continuous scale did not carry more ... |
|
| Simulated Evacuations Into Water |
AUG 2004 |
14 pages |
| Authors:
Garnet A. McLean; David A. Palmerton; Cynthia L. Corbett; Kenneth G. Larcher; Jerry R. McDown; FEDERAL AVIATION ADMINISTRATION OKLAHOMA CITY OK CIVIL AEROMEDICAL INST
|
| Transport airplanes are required to be assessed for ditching capability in the FAA type-certification process. This includes the airplane's emergency evacuation potential, i.e., the ability of passengers to escape the airplane after it lands on water. Actual emergency data to support ditching certification are not available; there have been questions as to whether evacuation flow rates onto land are appropriate for use in ditching-related flotation time computations. Simulated evacuations from ... |
|
| Cognitive-Affective Predictors of the Uptake of, and Sustained Adherence to, Lymphedema Symptom Minimization Practices in Breast Cancer Survivors |
AUG 2004 |
15 pages |
| Authors:
Suzanne M. Miller; FOX CHASE CANCER CENTER PHILADELPHIA PA
|
| Approximately 20-30% of women develop lymphedema (LE) following breast cancer treatment; this condition has been associated with psychological distress and diminished quality of life. Effective symptom management requires that women not only recognize early signs of this condition, but that they uptake and maintain precautionary practices over their lifetime. Yet, the limited data available indicate that knowledge and use of symptom minimization precautions are poor, particularly over time. Unfortunately, little ... |
|
| Cripto: A Target for Breast Cancer Treatment |
JUN 2004 |
54 pages |
| Authors:
Eileen D. Adamson; BURNHAM INST LA JOLLA CA
|
| Cripto is a growth factor that is important in breast cancer, leading to increases in cell proliferation and to increased survival of cells. Specific receptors for this factor have not been defined for breast cells but there is evidence from published work that Cripto acts as a co-factor for the Nodal factor, previously thought to be present and active only in early embryonic development. This work will define the importance ... |
|
| Vitronectin and Integrin alpha(v)Beta3 in Ovarian Carcinoma |
JUL 2003 |
13 pages |
| Authors:
Shuang Huang; SCRIPPS RESEARCH INST LA JOLLA CA
|
| Ovarian cancer is the leading gynecological cancer that results in death. Due to the lack of symptom in the early stage of disease, most ovarian cancers are diagnosed in the late stage. Current therapy such as chemotherapy is not very effective for curing ovarian cancer. This proposal aims to develop an adenovirus-based gene therapy for suppression ovarian malignancies. In our studies, we have found that the interaction between vitronectin and ... |
|
| Enhancing Well-Being During Breast Cancer Recurrence |
JUL 2003 |
68 pages |
| Authors:
Charles A. Coltman; CANCER THERAPY AND RESEARCH FOUNDATION SAN ANTONIO TX
|
| Significant numbers of breast cancer patients will experience a recurrence of their disease. Breast cancer recurrence is a time of enormous crisis, with significant distress, depression, and symptomatology, and few effective coping strategies. Targeted support services are currently unavailable. This study tests the hypothesis that patients experience greater well-being by participating in an intervention designed for breast cancer patients experiencing a first recurrence. - Following pilot study phase, 300 breast ... |
|
| Cripto: A Target for Breast Cancer Treatment |
JUN 2003 |
8 pages |
| Authors:
Eileen D. Adamson; BURNHAM INST LA JOLLA CA
|
| Cripto is a growth factor that is important in breast cancer, leading to increases in cell proliferation and to increased survival of cells. Specific receptors for this factor have not been defined for breast cells but there is evidence from published work that Cripto acts as a co-factor for the Nodal factor, previously thought to be present and active only in early embryonic development. This work will define the importance ... |
|
| Disorientation in Helicopter Ditching and Rigid Inflatable Boat Capsizement: Training is Essential to Save Crews |
FEB 2003 |
|
| Authors:
C. J. Brooks; SURVIVAL SYSTEMS LTD DARTMOUTH (NOVA SCOTIA)
|
| This paper discusses the disorientation problems of escape from a rigid inflatable boat (RIB) that has been capsized. It makes comparisons with executing a ditched helicopter underwater escape and emphasizes the need for realistic training for both RIB and helicopter crafts. Although very poor records are collected on RIB capsizements, each year there is a small but significant loss of life and many close calls. A paper at the Royal ... |
|
| Center for Behavioral Research: Individual Interventions for Breast Cancer Patients |
SEP 2002 |
6 pages |
| Authors:
Andrew Baum; PITTSBURGH UNIV PA
|
| This is an annual report for the Center for Biobehavioral Research in Breast Cancer, a center of excellence that was initially funded in September, 2001. The Center was designed to support, stimulate, conduct, and disseminate research and research reports on the biological and behavioral interactions characterizing the development and progression of breast cancer as well as treatment and survivor effects. Behavioral variables, particularly those directly related to activity in biological ... |
|
| Protein Kinase Pathways that Regulate Neuronal Survival and Death |
AUG 2002 |
94 pages |
| Authors:
Kim A. Heidenreich; COLORADO UNIV HEALTH SCIENCES CENTER DENVER
|
| Loss of post-mitotic neurons from the adult brain underlies the pathology of neurodegenerative diseases and neurotoxin expostire Neuronal cell death occurs by two mechanisms: necrosis and apoptosis. Apoptosis is a process whereby developmental cues and environmental stimuli activate a genetic program to implement a series of steps that culminate in cell death. An important aspect of apoptosis is that it can be halted and such interventions may rescue dying neurons. ... |
|
| Angiogenesis and Cancer Prevention by Selenium |
JUN 2002 |
86 pages |
| Authors:
Junxuan Lu; AMC CANCER RESEARCH CENTER DENVER CO
|
| Our overall aim is to understand the role of inhibition of angiogenesis by selenium (Se) in breast cancer chemoprevention. We first established the anti- angiogenesis phenomenon of chemopreventive intake of Se with data supporting an association of reduced microvessel density and decreased vascular endothelial growth factor expression with mammary cancer prevention by Se (Mol. Carcinog. 1999). We discovered a specific inhibitory effect of methylselenium on vascular endothelial expression of matrix ... |
|
| Liposomal Sphingolipids to Target Breast Adenocarcinoma Apoptosis |
JUN 2002 |
8 pages |
| Authors:
Jim Klostergaard; M D ANDERSON CANCER CENTER HOUSTON TX
|
| Over-expression of HER-2/neu has been linked to poorer prognosis and reduced survival in breast cancer patients The basis for this association is likely multifactorial and includes therapeutic resistance, such as resistance to Taxol (paclitaxel), widely used in many chemotherapeutic regimens for this disease We have recently observed that certain sphingolipids (e.g., dimethyl- sphingosune), either as free lipids or as constituents of liposomes, induce apoptosis in vitro in tumor cells despite ... |
|
| Blowing Hot and Cold: Protecting Against Climatic Extremes (Souffler le chaud et le froid: comment se proteger contre les conditions climstiques extremes) |
APR 2002 |
|
| Authors:
G. Havenith; NATO RESEARCH AND TECHNOLOGY AGENCY CEDEX (FRANCE)
|
| Exposure to heat and cold as well as the thermal stress induced by protective clothing strongly influences operational effectivity of the soldier. On 8-10 October 2001, NATO and Partner for Peace nationals met in Dresden Germany, to discuss the interaction between the climate, the clothing and equipment, and the physiology of the soldier in relation to its impact on the soldier's health and operational performance. 118 people participated in the ... |
|
| The Effects of Charge Separation in Quaternary Ammonium, DABCO-Containing Polymers on In Vitro Toxicity and Gene Delivery |
APR 2002 |
|
| Authors:
Theresa M. Reineke; Mark E. Davis; CALIFORNIA INST OF TECH PASADENA DIV OF CHEMISTRY AND CHEMICAL ENGINEERING
|
| Polycation materials have recently emerged as promising systems for the delivery of genetic material. In this study, several DABCO (1,4-diazabicyclo2.2.2octane) polymers are investigated for their ability to bind and deliver plasmid DNA (pDNA) into mammalian cells. The DABCO polymers are synthesized by copolymerization of DABCO with 1,3- dibromopropane (D3), 1,4-dibromobutane (D4), 1,6-dibromohexane (D6), 1,8-dibromooctane (D8), and 1,10-dibromodecane (D10) to form a series of quaternary ammonium polymers with increasing charge separation. ... |
|
| Four Portraits of the Plague Organism |
JAN 2002 |
8 pages |
| Authors:
Millard M. Mershon; ARMY MEDICAL RESEARCH AND MATERIEL COMMAND FORT DETRICK MD
|
| Yersinia pestis organisms have infective and self-protective features that are expressed or suppressed to fit different conditions. The Y. pestis bacteria respond selectively to a variety of signals (which occur inside or outside of diverse hosts and cells) by expressing products that ultimately promote the multiplication and survival of the organisms. This paper briefly outlines the dynamics and time courses of the warfare between invading bacteria and susceptible hosts. At ... |
|
| Treatment with the Humanized CD154-Specific Monoclonal Antibody, hu5C8, Prevents Acute Rejection of Primary Skin Allografts in Nonhuman Primates |
15 NOV 2001 |
|
| Authors:
Eric A. Elster; He Xu; DOuglas Tadaki; Sean Montgomery; Linda Burkly; NATIONAL INSTITUTES OF HEALTH BETHESDA MD
|
| Allogeneic skin transplantation remains a rigorous test of any immune intervention designed to prevent allograft rejection. To date no single clinically available immunosuppressant has been reported to induce long-term primary skin allograft survival in privates. We have previously shown that treatment with the humanized CD 154- specific monoclonal antibody humanized 5C8 (hu5C8) induces long-term renal allograft survival in nonhuman privates. In this study we evaluated the efficacy of hu5C8 in ... |
|
| Preclinical Evaluation of Tolerance Induction Protocols and Islet Transplantation in Non-Human Primates |
01 OCT 2001 |
|
| Authors:
Sean P. Montgomery; Douglas A. Hale; Boaz Hirshberg; David M. Harlan; Allan D. Kirk; NATIONAL INSTITUTES OF HEALTH BETHESDA MD
|
| Clinical solid organ transplantation has advanced tremendously over the past two decades. One-year graft survival exceeds 95%, 90% and 80% for kidney, liver and heart grafts, respectively . This improvement has been fueled predominantly by the expanding repertoire of progressively more potent immunosuppressive agents at our disposal. Unfortunately, modern therapies remain imperfect. Despite excellent short-term graft survival rates and low rates of acute rejection attained routinely today, there is an ... |
|
| Does Subsequent Pregnancy Influence Breast Cancer Survival |
OCT 2001 |
24 pages |
| Authors:
Jeanne A. Petrek; Catherine Schaefer; Ann Zauber; Ruby Senie; SLOAN-KETTERING INST FOR CANCER RESEARCH NEW YORK
|
| Among young breast cancer patients, desires for future childbearing may impact treatment decisions and quality of life. Although changes in adjuvant therapy have enabled maintenance of fertility, many oncologists encourage their patients to delay childbearing fearing recurrent disease may be stimulated by hormonal elevations of pregnancy. The current retrospective study based on medical record review was conducted collaboratively with researchers of the Kaiser Permanente Research Foundation in Northern California. Computerized ... |
|
| Coadministration of Either Cyclosporine or Steroids with Humanized Monoclonal Antibodies Against CD80 and CD86 Successfully Prolong Allograft Survival After Life Supporting Renal Transplantation in Cynomolgus Monkeys |
27 SEP 2001 |
|
| Authors:
Bernad Hausen; Jochen Klupp; Uwe Christians; John P. Higgins; Roxanne E. Baumgartner; NATIONAL INSTITUTES OF HEALTH BETHESDA MD
|
| Recent studies have shown some efficacy using monotherapy with monoclonal antibodies (mAb) against CD8O and CD86 receptors after life- supporting renal transplantation in non-human primates. Our study was designed to evaluate the efficacy of combinations of the same mAbs with either microemulsion cyclosporine (CsA) or steroids. |
|
| Comparison of Novel and Known Neuroprotectants for Treating Exposure to Different Types of Toxins |
SEP 2001 |
|
| Authors:
Ben H. Bahr; CONNECTICUT UNIV STORRS
|
| AMPA receptors mediate glutamatergic neurotransmission and, when intensely activated, can induce synaptic deterioration and excitotoxic cell death. However, AMPA stimulation was found to cause pronounce activation of the mitogen-activated protein kinase (MAPK) in hippocampal field CAl and less so in CA3 and dentate gyrus (DO). Inhibition of the AMPA receptor-MAPK pathway potentiated neuronal vulnerability, suggesting that this pathway facilitates injury-induced compensatory signals. Correspondingly, positive modulation of the pathway with Ampakine ... |
|
| Mechanisms and Components of the DNA Damage Checkpoint |
SEP 2001 |
|
| Authors:
Marc F. Schwartz; David Stern; YALE UNIV NEW HAVEN CT
|
| Survival of genotoxic stress is essential to the survival of any organism. The DNA damage checkpoint (DDC) is a regulatory system that controls the cellular response to DNA damage. Dysfunction of components of the mammalian DDC, such as ATM, hChk2, p53, and BRCAl, correlates with increased cancer risk. DDC mechanisms are conserved; in Saccharomyces cerevisiae, ATM-family kinase MEC1 is required for the DDC, as are hChk2- homolog Rad53 and BRCAl-like ... |
|
| DNA Vaccination Against Metastatic Breast Cancer |
JUL 2001 |
|
| Authors:
Lawrence Lachman; M D ANDERSON CANCER CENTER HOUSTON TX
|
| RER2/neu over-expression is found in 30-40% of breast cancer biopsy and is indicative of metastasis and poor prognosis. A DNA vaccine targeting HER2/neu could have significant therapeutic and preventative application by controlling the growth and spread of highly aggressive HER2/neu+ cells. Although DNA vaccines have shown effectiveness in clinical trials, it is essential to demonstrate pre-clinical effectiveness for anti-tumor DNA vaccines before clinical testing can begin. We have shown that ... |
|
| Race Differences in Breast Cancer Survival |
JUL 2001 |
|
| Authors:
Beth A. Jones; YALE UNIV NEW HAVEN CT
|
| This is a population based follow-up study of 145 African American (AA) and 177 white (W) women who were diagnosed with breast cancer between January, 1987 and May, 1989. As of January, 1999, 135 (41.9%) of the women had died. survival among AA women (56.9%) was significantly lower than survival in W women (68.9%) AGE-ADJUSTED Risk Ratio ?RR! 1.73 (95% Confidence Interval ?CI! 1.21 - 2.48!. The significant survival disadvantage ... |
|
| Bone Factors Regulating the Osteotropism of Metastastic Breast Cancer |
OCT 2000 |
|
| Authors:
Peter V. Hauschka; CHILDREN'S HOSPITAL CORP BOSTON MA
|
| Malignant breast adenocarcinoma cells mimic osteoblasts, a critical step in their metastatic colonization and destruction of bone. CBFAl, a transcription factor responsible for normal osteoblast differentiation, is expressed inappropriately by the human breast adenocarcinoma cell line MDA-MB-23 1, and about 2-fold more strongly by a subline Ml, recovered from an osteolytic bone metastasis of MDA-MB-23 1 in a nu/nu mouse. CBFAl expression was not detected in normal breast epithelium (HMEC ... |
|
| Molecular Analysis of Neurotoxin - Induced Apoptosis |
SEP 2000 |
47 pages |
| Authors:
Santosh R. D'Mello; TEXAS UNIV AT DALLAS RICHARDSON
|
| Apoptosis, a cell-suicide process required for normal brain development, can also be aberrantly triggered in certain neurodegenerative diseases and following exposure to neurotoxins. We hypothesize that certain components of the signaling pathways activated by these different physiological and pathophysiological stimuli might be shared and could serve as targets for the development of therapeutic approaches. In our application, we proposed to compare the signaling pathways ... |
|
| Protein Kinase Pathways that Regulate Neuronal Survival and Death |
AUG 2000 |
132 pages |
| Authors:
Kim A. Heidenreich; COLORADO UNIV HEALTH SCIENCES CENTER DENVER
|
| Loss of post-mitotic neurons from the adult brain underlies the pathology of neurodegenerative diseases and neurotoxin exposure. Neuronal cell death occurs by two mechanisms; necrosis and apoptosis. Apoptosis is a process whereby developmental cues and environmental stimuli activate a genetic program to implement a series of steps that culminate in cell death. An important aspect of apoptosis is that it can be halted and such interventions ... |
|
| Knock-out and Transgenic Strategies to Improve Neural Transplantation Therapy for Parkinson's Disease |
JUL 2000 |
133 pages |
| Authors:
Ole Isacson; MCLEAN HOSPITAL BELMONT MA
|
| The remaining obstacles to achieving reliable therapeutic effects by neurotransplantation for Parkinson's disease (PD) are 1) poor survival of grafted fetal neurons and 2) insufficient axonal outgrowth and functional recovery. We carried out experiments aimed at by short-term inhibition by pre- treatment of fetal cells with pharmacological inhibitors of caspases. In our second objective of enhancing axonal growth leading to optimal functional recovery by ... |
|
| Alterations in the Local Axonal Environment Influence Target Reinnervation and Neuronal Survival after Postnatal Axotomy |
21 JUN 2000 |
157 pages |
| Authors:
Hugh M. Dainer; UNIFORMED SERVICES UNIV OF THE HEALTH SCIENCES BETHESDA MD DEPT OF ANATOMY AND CELL BIOLOGY
|
| Following peripheral nerve injury in adult animals, Schwann cells (SC) proliferate and provide guidance in the local axonal environment by generating the infrastructure along which regenerating nerves grow. A portion of the SC in the peripheral nerves of postnatal rats undergo apoptosis during normal development, and this apoptosis is augmented at the injury site and the neuromuscular junction (NMJ) following sciatic nerve axotomy. The current work determined that SC apoptosis ... |
|
| The Sentinel Lymph Node as a Disease Prognosticator in Node Negative Breast Cancer |
JUN 2000 |
|
| Authors:
Julie R. Lange; JOHNS HOPKINS UNIV BALTIMORE MD SCHOOLOF MEDICINE
|
| The purpose of this study is to use sentinel node technology to better predict prognosis for node-negative breast cancer patients. Patients with a new diagnosis of unilateral, unifocal breast cancer and a clinically negative axilla were offered enrollment in this protocol. Sentinel nodes were localized and resected along with a standard staging axillary dissection. The sentinel nodes were processed in standard fashion and were then retained for specialized studies including ... |
|
| Successful Conversion from Conventional Immunosuppression to Anti-CD154 Monoclonal Antibody Costimulatory Molecule Blockade in Rhesus Renal Allograft Recipients |
02 APR 2000 |
13 pages |
| Authors:
Clifford S. Cho; Linda C. Burkly; John H. Fechner Jr.; Allan D. Kirk; NATIONAL INSTITUTES OF HEALTH BETHESDA MD
|
| Several conventional forms of immunosuppression have been shown to antagonize the efficacy of anti-CDt 54 monoclonal antibody- (mAb) based costimulatory molecule blockade immunotherapy. Our objective was to determine if allograft recipients treated with a conventional immunosuppressive regimen could be sequentially converted to anti- CD1 54 mAb monotherapy without compromising graft survival. |
|
| Dominant-Active Alleles of Rb as Universal Tumor Suppressors of Mammary Carcinoma |
OCT 1999 |
19 pages |
| Authors:
Eldad Zacksenhaus; TORONTO GENERAL HOSPITAL (ONTARIO)
|
| The tumor suppressor Rb is a nuclear-phosphoprotein that controls cell proliferation, survival and differentiation and is thought to be either mutated or functionally inactivated by phosphorylation in virtually all human cancer including breast cancer. We developed transgenic mouse models to study the outcomes of upregulating the Rb pathway in the mammary gland and test whether Rb is a universal tumor suppressor. Unphosphorylatable alleles of Rb ... |
|
| Managing Menopausal Symptoms in Breast Cancer Survivors |
OCT 1999 |
93 pages |
| Authors:
Patricia A. Ganz; CALIFORNIA UNIV LOS ANGELES
|
| Menopausal symptoms commonly occur in breast cancer survivors. In this research program we evaluated the efficacy of a comprehensive menopausal assessment (CMA) and intervention program for management of menopausal symptoms (hot flashes, vaginal dryness, urinary incontinence) in this target population. Primary outcomes were symptom relief and energy/vitality, with sexual functioning as a secondary outcome. We recruited 72 moderately symptomatic breast cancer survivors who ... |
|
| Race Differences in Breast Cancer Survival |
JUL 1999 |
|
| Authors:
Beth Jones; YALE UNIV NEW HAVEN CT SCHOOL OF MEDICINE
|
| This is a follow-up study of a cohort of African-American and Caucasian women who were diagnosed with breast cancer in the late 1980's. Its purpose is to examine race differences (black/white) in breast cancer survival. In addition to measuring survival and examining racial differences in survival, this study also seeks to identify prognostic factors related to survival for the study population and to determine if the prognostic indicators are the ... |
|
| TRICARE Marketing Analysis for the 3 Medical Group Elmendorf Air Force Base, AK |
17 MAY 1999 |
205 pages |
| Authors:
Wendy L. Barnes; AIR FORCE INST OF TECH WRIGHT-PATTERSONAFB OH
|
| The 3rd Medical Group (3MDG) operates in a unique environment. The state of Alaska is geographically isolated, medically under-served throughout the state, devoid of health maintenance organizations (HMOs), and monopolistically aligned for specialty healthcare services. In addition to thesefactors, healthcare costs continue to rise while the Department of Defense (DOD)faces even slimmer budgetary authorizations. Given these challenges, the 3MDG must continue to provide quality care to approximately 40,200 beneficiaries who ... |
|
| Estimated DCS Risks in Pressurized Submarine Rescue |
APR 1999 |
52 pages |
| Authors:
P. K. Weathersby; S. S. Survanshi; E. C. Parker; D. J. Tample; C. B. Toner; NAVAL MEDICAL RESEARCH CENTER BETHESDA MD
|
| The Naval Submarine Medical Research Laboratory (NSMRL) Report "Pressurized submarine rescue: a manual for undersea medical officers" issued in 1992 contained a number of decompression procedures with a conservatism appropriate to routine U.S. Navy diving operations. Current planning emphasizes the need for procedures that, although sub-optimal from some viewpoints, allow maximum efficiency in protecting survivors from life-threatening decompression sickness (DCS). Available probabilistic decompression models were applied to six relevant rescue ... |
|
| Surveillance After Initial Treatment for Breast Cancer: A Population- Based Study of Variation in and Outcomes of Care |
OCT 1998 |
20 pages |
| Authors:
Ann B. Nattinger; MEDICAL COLL OF WISCONSIN MILWAUKEE
|
| This purpose of this report is to describe the use of follow-up tests (mammograms, chest radiographics, and bone scans) and office visits among breast cancer survivors. Determinants of testing, and use of tests among a control population, are also described. Among a cohort of breast cancer survivors aged 65 and older who developed breast cancer in 1991 and underwent surgical treatment, the rate of use of mammography and chest radiographs ... |
|
| Civil Engineers Hone Search, Rescue Skills at Combat Town |
27 AUG 1998 |
4 pages |
| Authors:
Brent C. Powell; MARINE CORPS WASHINGTON DC
|
| When disasters such as earthquakes, hurricanes or even a bombing devastate a city, someone has to sift through the rubble and look for survivors. A group of civil engineers recently journeyed here in order to prepare themselves to do just that. The System To Locate Survivors (STOLS) team which consist of 12 civil engineers from the Japan Engineer District (JED) from Camp Zama in mainland Japan, ... |
|
| Modulation of T-Cell Activation in an Experimental Model of Mammary Carcinoma |
JUL 1998 |
28 pages |
| Authors:
Arthur A. Hurwitz; CALIFORNIA UNIV BERKELEY
|
| One of the major goals of tumor immunotherapy is the induction of tumor-specific T cell responses that will be effective at eradicating disseminated tumors. The studies described in this update take advantage of our current knowledge of T cell activation and inhibitory signals. Using a transplantable mammary carcinoma, we demonstrated that blockade of inhibitory signals mediated by CTLA-4 using a monoclonal antibody synergizes with ... |
|
| Investigations of Functional and Structural Interactions Between c-src and HER2: Involvement in Human Breast Tumor Formation |
JUL 1998 |
|
| Authors:
Allison P. Belsches; VIRGINIA UNIV CHARLOTTESVILLE
|
| Overexpression of HER family members and c-Src occurs in a majority of human breast cancers, suggesting the two tyrosine kinases may cooperate during neoplastic transformation. Synergism between c-Src and HER1 in tumorigenesis has been demonstrated in a murine fibroblast model and supported by studies in human breast cancer cells. To investigate whether c-Src/HER2 interactions may also play a role in breast tumor progression, we characterized a panel of thirteen human ... |
|
Reports by Keyword(s)
SURVIVAL(PERSONNEL)
