| To Stay a Soldier |
Oct-2009 |
11 pages |
| Authors:
Chuck Callahan; ARMY WAR COLL CARLISLE BARRACKS PA
|
 | Doc, if you try to take me out of the 82d, you'll be hearing from my congressman. The young soldier with tattooed arms strained against the bedrails, his eyes searching the doctor's face above, his twisted, purplish leg surrounded by a black steel cage of bolts and rods that held his shattered bones together. He was one of many men and women wheeled from surgery to therapy to their rooms ... |
|
| Review of Efforts to Develop a Low-Luminance-Level Disability Glare Tester |
Sep-2009 |
68 pages |
| Authors:
Melvyn E Kalich; Lisa J Lewis; Alejandra Mora; Lisa M Lont-Dueringer; Gina M Bissette; Herber D Jones; ARMY AEROMEDICAL RESEARCH LAB FORT RUCKER AL
|
| This report describes USAARL's efforts to develop a disability glare tester that could be used for predicting night vision problems resulting from post refractive surgery, particularly for U. S. Army aviators. The nature & complexity of the problem are reviewed, along with current methods for assessing disability glare. The best current techniques focus on measuring & evaluating the effects of forward scatter in the eye. While elegant, forward scatter measurements ... |
|
| Determination of Critical Factors in Unmanned Casualty Evacuation in the Distributed Environment |
Jun-2009 |
67 pages |
| Authors:
Ralph L Featherstone; NAVAL POSTGRADUATE SCHOOL MONTEREY CA
|
| The current battlefield is changing rapidly. Combat operations against irregular forces are set in a dispersed, non-linear battlefield. Vast distances between small units such as the infantry squad, and the distances from these small elements to their supporting organizations, pose unique challenges. Casualty evacuation is an evolving challenge. The goal of casualty evacuation is to transport an injured Marine from the point of injury to a medical care facility. Increased ... |
|
| Molecular Solutions to Low Vision Resulting from Battlefield Injuries. Addendum |
May-2009 |
12 pages |
| Authors:
Darlene A Dartt; SCHEPENS EYE RESEARCH INST BOSTON MA
|
| We hypothesize that targeted molecular intervention can preserve vision threatened by battlefield trauma-induced corneal and retinal inflammation, corneal and retina/optic nerve apoptosis, ocular surface dry eye after refractive surgery, and retinal degeneration. We are studying the consequences of trauma-induced (1) corneal inflammation using a gene therapy approach of providing soluble Fas ligand to the cornea to determine if this ligand can suppress corneal inflammation in mice; (2) retinal inflammation by ... |
|
| The Impact of Prostate Cancer Treatment-Related Symptoms on Low-Income Latino Couples |
Mar-2009 |
12 pages |
| Authors:
Sally L Maliski; CALIFORNIA UNIV LOS ANGELES
|
| Prostate cancer is the most commonly diagnosed non-skin cancer among men in the United States. Even when prostate cancer is diagnosed and treated early, there are a number of side effects that can have an impact on a man's quality of life, including erectile dysfunction, incontinence, and a diminished desire for sexual relations. Because of these treatment side effects, prostate cancer is often considered a couples' disease. The purpose of ... |
|
| Cancer Localization in the Prostate with F-18 Fluorocholine Positron Emission Tomography |
15-Jan-2009 |
36 pages |
| Authors:
Sandi A Kwee; Gregory Thibault; Richard Stack; Marc N Coel; Isabel A Isabel; QUEEN'S MEDICAL CENTER HONOLULU HI
|
| The project evaluated fluorine-18 (18F-) fluorocholine positron emission tomography (PET) as an imaging technique for delineating malignancy in the prostate gland. The technique measures tissue metabolism of fluorocholine, a substrate that is preferentially metabolized by cancer cells due to malignant over-expression of the choline transporter and choline kinase enzyme. Based on this measurement, it was proposed that cancerous tissue can be differentiated from benign tissue in the prostate. Project Scope: ... |
|
| Development of a Tissue Engineered Scaffold for Meniscus Replacement |
Dec-2008 |
8 pages |
| Authors:
E A Balint; Gatt; C J Jr; M G Dunn; ROBERT WOOD JOHNSON UNIV HOSPITAL NEW BRUNSWICK NJ
|
| It is well accepted that the loss of meniscal function due to surgical removal is a significant factor in the onset of degenerative osteoarthritis of the knee. Few viable alternatives exist for the replacement of significantly damaged tissue. In this study, two potential designs for meniscus scaffolds were compared with a focus on the mechanical protection they provide the articular surfaces and their overall biological incorporation into synovial tissue. Three ... |
|
| Patterns of Care and Disparities in the Treatment of Early Breast Cancer |
30-Sep-2008 |
39 pages |
| Authors:
Grace Smith; M D ANDERSON CANCER CENTER HOUSTON TX
|
| Prior research evidence that has suggested that regional variation and socioeconomic barriers in breast cancer treatment remain substantial problems for patients across the nation. The purpose of our project was to characterize national patterns in the treatment of early invasive breast cancer in older women with incident disease. We specifically sought to characterize disparities in care and regional variation in treatment patterns. Methods. We sought to apply a novel resource, ... |
|
| Modulation of PPAR-Gamma Signaling in Prostatic Carcinogenesis |
Sep-2008 |
10 pages |
| Authors:
Simon W Hayward; VANDERBILT UNIV MEDICAL CENTER NASHVILLE TN
|
| The long term objective of this work is to elucidate metabolic pathways which can be used to reduce the need for radical surgery in patients at high risk for prostate cancer or with early stage disease. The hypothesis to be tested is that alterations to lipoxygenase (LOX) and cyclooxygenase (COX) activity in early prostate cancer represent distinct druggable pathways which can be treated in conjunction with the PPAR-gamma signaling pathway ... |
|
| Integrated Molecular Imaging and Therapy for Breast Cancer |
Aug-2008 |
24 pages |
| Authors:
Balaji Panchapakesan; DELAWARE UNIV NEWARK
|
| In this project, we have demonstrated multi-component molecular targeting of surface receptors (IGF1R and Her2) and NIR dosing of cancer cells using SWCNT. While previous studies have shown the transport of DNA into cells using nanotubes, in this study we show multi-component molecular targeting of both IGF1R and Her2 surface markers in cancer cells using single wall carbon nanotubes. IGF1 and Her2 specific antibodies conjugated to the SWCNT were used ... |
|
| Methods of Advanced Wound Management for Care of Combined Traumatic and Chemical Warfare Injuries |
21-Jul-2008 |
22 pages |
| Authors:
John S Graham; Thomas P Logan; Travis W Gerlach; James P Bonar; Richard J Fugo; Robyn B Lee; Matthew A Coatsworth; ARMY MEDICAL RESEARCH INST OF CHEMICAL DEFENSE ABERDEEN PROVING GROUND MD
|
| Chemical warfare agents are potential threats to military personnel and civilians. The potential for associated traumatic injuries is significant. Damage control surgery could expose medical personnel to agents contaminating the wounds. The objectives of this study were to demonstrate efficacy of surgical decontamination and assess exposure risk to attending personnel. Methods: Weanling pigs were randomly assigned to 2 of 4 debridement tools (scalpel, BovieR knife, Fugo BladeR , and VersajetTM ... |
|
| Molecular Solutions to Low Injuries Resulting from Battlefield Injuries. Addendum |
01-May-2008 |
19 pages |
| Authors:
Darlene A Dartt; SCHEPENS EYE RESEARCH INST BOSTON MA
|
| We hypothesize that targeted molecular intervention can preserve vision threatened by battlefield trauma-induced corneal and retinal inflammation, corneal and retina/optic nerve apoptosis, ocular surface dry eye after refractive surgery, and retinal degeneration. We are studying the consequences of trauma-induced (1) corneal inflammation using a gene therapy approach of providing soluble Fas ligand to the cornea to determine if this ligand can suppress corneal inflammation in mice; (2) retinal inflammation by ... |
|
| 2007 International Brain Mapping and Intraoperative Surgical Planning Society's (IBMISPS) Annual World Congress |
01 FEB 2008 |
976 pages |
| Authors:
Babak Kateb; INTERNATIONAL BRAIN MAPPING AND ISP SOCIETY WEST HOLLYWOOD CA
|
| The third annual meeting of International Brain Mapping & Intra-operative Surgical Planning Society (IBMISPS) was held in Washington D:www.IBMISPS.Org. The Society is organized for the purpose of encouraging leading basic and clinical scientists who are interested or active in areas of Brain Mapping (BM) and intra-operative Surgical planning (ISP) to share their findings with other physicians and scientists across the disciplines. Currently, there is no combined conference on both subjects. ... |
|
| Advanced Technologies in Safe and Efficient Operating Rooms |
FEB 2008 |
179 pages |
| Authors:
Adrian E. Park; MARYLAND UNIV MEDICAL CENTER BALTIMORE
|
| The three major research targets of this study are (a) OR informatics, (b) simulation research, and (c) smart image. The purpose of the OR informatics program is to develop, test, and deploy technologies to collect real-time data about key tasks and process elements in clinical operating rooms. The objective of simulation research is to create a system where a user can interact with a virtual human model in cognitive simulation ... |
|
| Pediatric Care as Part of the US Army Medical Mission in the Global War on Terrorism in Afghanistan and Iraq, December 2001 to December 2004 |
FEB 2008 |
8 pages |
| Authors:
Mark W. Burnett; Philip C. Spinella; Kenneth S. Azarow; Charles W. Callahan; TRIPLER ARMY MEDICAL CENTER HI
|
| OBJECTIVE. Our objective in this report was to describe the epidemiologic features of and workload associated with pediatric admissions to 12 US Army military hospitals deployed to Iraq and Afghanistan. METHODS. The Patient Administration Systems and Biostatistics Activity database was queried for all local national patients |
|
| Complications After Fasciotomy Revision and Delayed Compartment Release in Combat Patients |
FEB 2008 |
|
| Authors:
Amber E. Ritenour; Warren C. Dorlac; Raymond Fang; Timothy Woods; Donald H. Jenkins; Stephen F. Flaherty; Charles E. Wade; John B. Holcomb; ARMY INST OF SURGICAL RESEARCH FORT SAM HOUSTON TX
|
 | Background: Incomplete or delayed fasciotomies are associated with muscle necrosis and death in civilian trauma. Combat explosions severely damage tissue and distort normal anatomy making fasciotomies challenging. Rapid air evacuation may delay treatment of patients with evolving extremity compartment syndrome. We investigated the impact of fasciotomy revision and delayed compartment release on combat casualties after air evacuation. Methods: A retrospective review was performed of combat casualties who underwent fasciotomies in ... |
|
| Robotic Prostate Biopsy in Closed MRI Scanner |
FEB 2008 |
68 pages |
| Authors:
Gregory Fischer; JOHNS HOPKINS UNIV BALTIMORE MD
|
| MRI possess many of the capabilities that TRUS is lacking for prostate brachytherapy and biopsy, with high sensitivity for detecting prostate tumors, high spatial resolution, excellent soft tissue contrast, and volumetric imaging capabilities. However, closed-bore high-field MRI has not been widely adopted for prostate interventions because strong magnetic fields and confined physical space present formidable challenges. This work enables prostate brachytherapy and biopsy procedures in standard high-field diagnostic MRI scanners ... |
|
| Journal of Special Operations Medicine. Volume 8, Edition 1, Winter 2008 |
Jan-2008 |
137 pages |
| Authors:
JOINT SPECIAL OPERATIONS UNIV HURLBURT FIELD FL
|
| This issue of the JSOM follows the December 2007 Special Operations Medical Association (SOMA) meeting here in Tampa. SOMA continues to grow; we expected 1000 attendees perhaps, up from 800 last year, and ended up getting more like 1200. I attached some of the slides that I presented at SOMA at the end of this column. We plan to publish another JSOM Lesson Learned Supplement, which will include more from ... |
|
| Cancer Localization in the Prostate with F-18 Fluorocholine Position Emission Tomography |
JAN 2008 |
33 pages |
| Authors:
Sandi Kwee; QUEEN'S MEDICAL CENTER HONOLULU HI
|
| The project evaluated fluorine-18 (F-18) fluorocholine positron emission tomography (PET) as an imaging technique for delineating malignancy in the prostate gland% The technique measures tissue metabolism of fluorncholine, a substrate that is preferentially metabolized by cancer cells due to malignant over-expression of the choline transporter and choline kinase enzyme. Based on this measurement, it was proposed that cancerous tissue can be differentiated from benign tissue in the prostate. Project Scope: ... |
|
| Business Case Analysis of the Walter Reed Army Medical Center Medical/Surgical Prime Vendor Generation III Service Level Electron Program |
25 OCT 2007 |
96 pages |
| Authors:
Peter B. Markot; WALTER REED ARMY MEDICAL CENTER WASHINGTON DC
|
| The purpose of the business case analysis was to determine what combination of Full-Time Equivalent (FTE) staffing and medical/surgical services offered under the Prime Vendor (PV) Generation III contract would provide the best supply chain management solution for Walter Reed Army Medical Center (WRAMC). In support, three scenarios were developed with various combinations of FTE staffing and PV service options in order to determine a best value solution. Results of ... |
|
| Air Force Operational Medicine: Using the Estimating Supplies Program to Develop Materiel Solutions for the Operational Clinical Requirements for the U.S. Air Force Otolaryngology Team (FFENT) |
10 OCT 2007 |
90 pages |
| Authors:
Curt Hopkins; Ralph Nix; Paula Konoske; Gerry Pang; Martin Hill; Tracy Negus; Kathleen Onofrio; NAVAL HEALTH RESEARCH CENTER SAN DIEGO CA
|
| The U.S. Air Force Medical Support Agency, Surgeon General Support Logistics Office, requested that the Naval Health Research Center (NHRC) conduct a proof of concept study to assess the validity and feasibility of using NHRC's medical modeling tool for the development and management of Air force medical Allowance Standards as a baseline for standardization throughout the armed services. The primary objective of this study was to provide the Air Force ... |
|
| Center for the Evaluation of Biomarkers for Early Detection of Breast Cancer |
OCT 2007 |
29 pages |
| Authors:
Nicole Urban; FRED HUTCHINSON CANCER RESEARCH CENTER SEATTLE WA
|
| Breast Cancer remains a leading cause of death for women in the US despite the popularity of mammography as a preventive tool. At diagnosis many breast cancers are at an advanced stage of disease even for women undergoing annual screening resulting in costly and painful follow-up procedures. It has been shown that molecular markers can increase our ability to diagnose early stages tumors. This has been demonstrated by current clinical ... |
|
| An Analysis of the Impact of AHLTA Implementation on Provider Productivity at Naval Hospital Jacksonville, FL |
29 AUG 2007 |
43 pages |
| Authors:
Diego Esguerra; NAVAL HOSPITAL JACKSONVILLE FL
|
| Naval Hospital Jacksonville, FL, implemented the use of an electronic medical record (AHLTA) in November 2005. Following the installation of AHLTA, productivity decreased. This study measured productivity at the provider level during each period. The dependent variable for this study was productivity, defined as Relative Value Units (RVU) divided by encounters. Regression results indicated that the overall model significantly predicted provider productivity, albeit weakly: R2=.249, R2 adj=.237, F(12, 759)=20.63, p ... |
|
| International Brain Mapping |
01 AUG 2007 |
33 pages |
| Authors:
Babek Kateb; INTERNATIONAL BRAIN MAPPING AND ISP SOCIETY WEST HOLLYWOOD CA
|
| The third annual meeting International Brain Mapping & Intra-operative Surgical Planning Society (IBMISPS) was held in Clermont Ferrand, France (Sep 5-8, 2006). The Society is organized for the purpose of encouraging leading basic and clinical scientists who are interested in or active in areas of Brain Mapping (BM) and Intra-operative Surgical Planning (ISP) to share their findings with other physicians and scientists across disciplines. Currently there is no combined conference ... |
|
| Integrated Molecular Imaging and Therapy for Breast Cancer |
AUG 2007 |
33 pages |
| Authors:
Balaji Panchapakesan; DELAWARE UNIV NEWARK
|
| In this project, we have demonstrated multi-component molecular targeting of surface receptors (IGF1R and Her2) and NIR dosing of cancer cells using SWCNT. While previous studies have shown the transport of DNA into cells using nanotubes, in this study we show multicomponent molecular targeting of both IGF1R and Her2 surface markers in cancer cells using single wall carbon nanotubes. IGF1 and Her2 specific antibodies conjugated to the SWCNT were used ... |
|
| Operating Room Utilization at Frederick Memorial Hospital |
JUL 2007 |
50 pages |
| Authors:
Jonathan A. Edwards; FREDERICK MEMORIAL HOSPITAL MD
|
| The purpose of this research was to identify opportunities for improvement for Frederick Memorial Hospital operating room utilization rates. A logistical regression analysis was used to identify the impact of variables on operating room utilization rates and therefore help explain how or why some operating rooms incurred higher utilization rates than others. Potentially, this retrospective study can help identify areas of improvement that continue to exist in the operating room ... |
|
| Molecular Solutions to Low Injuries Resulting from Battlefield Injuries |
01 MAY 2007 |
17 pages |
| Authors:
Darlene A. Dartt; SCHEPENS EYE RESEARCH INST BOSTON MA
|
| We hypothesize that targeted molecular intervention can preserve vision threatened by battlefield trauma-induced corneal and retinal inflammation, corneal and retina/optic nerve apoptosis, ocular surface dry eye after refractive surgery, and retinal degeneration. We are studying the consequences of trauma-induced (1) corneal inflammation using a gene therapy approach of providing soluble Fas ligand to the cornea to determine if this ligand can suppress corneal inflammation in mice; (2) retinal inflammation by ... |
|
| Alcohol Intoxication Impact on Outcome from Traumatic Injury |
MAY 2007 |
30 pages |
| Authors:
Patricia E. Molina; LOUISIANA STATE UNIV NEW ORLEANS
|
| The incidence of traumatic injury in alcohol-intoxicated individuals has continued to escalate during recent years. Traumatic injury is responsible for the greatest number of years of potential life lost before age 65; higher than that attributed to cancer, heart disease and HIV. Approximately 25% of injuries treated in emergency departments are alcohol related. Alcohol-intoxicated injured victims are likelier to present with more severe injury. Although improved resuscitation of trauma patients ... |
|
| Vulnerary Factors to Improve Bone Healing |
APR 2007 |
8 pages |
| Authors:
Jeffrey O. Hollinger; CARNEGIE-MELLON UNIV PITTSBURGH PA
|
| The objective for the work was to process rabbit bone specimens from the Institute of Surgical Research, foliwed by sectioning and staining of the samples No patents application were filed The rabbit bone samples were received fixed in 70% alcohol Bone was cut longitudinally (Figure lA) and cross-sectionally (Figure 2A) on a diamond band saw and thereafter processed (dehydrated and infiltrated with xylene) according to the following schedule: 1 70% ... |
|
| Colon and Rectal Injuries During Operation Iraqi Freedom: Are There Any Changing Trends in Management or Outcome |
APR 2007 |
9 pages |
| Authors:
Scott R. Steele; Kate E. Wolcott; Philip S. Mullenix; Matthew J. Martin; James A. Sebesta; Kenneth S. Azarow; Alec C. Beekley; MADIGAN ARMY MEDICAL CENTER TACOMA WA
|
| %: Despite the evolution in the management of traumatic colorectal injuries in both civilian and military settings during the previous few decades they continue to be a source of significant morbidity and mortality. The purpose of this study was to analyze management and clinical outcomes from a cohort of patients suffering colorectal injuries. |
|
| Medical Situational Awareness in the Theater (MSAT) |
23 MAR 2007 |
48 pages |
| Authors:
Robert DeFraites; ARMY MEDICAL RESEARCH AND MATERIEL COMMAND FORT DETRICK MD
|
| This report documents the successful execution of the United States Army Medical Research and Materiel Command (USAMRMC) responsibilities as Executing Activity for the Medical Situational Awareness in the Theater (MSAT) Advanced Concept Technology Demonstration (ACTD). The MSAT Implementation Directive (ID) (January 05) directed, &The Commanding General, United States Army Medical Research and Materiel Command (USAMRMC) will be the Executing Agent and will appoint and provide oversight to the Technical Manager ... |
|
| Mechanism of Telomerase Inhibition Using Small Inibitory RNAs and Induction of Breast Tumor Cell Sensitivity |
01 MAR 2007 |
21 pages |
| Authors:
Kennon R. Poynter; Shawn Holt; VIRGINIA COMMONWEALTH UNIV RICHMOND
|
| Telomerase, a ribonucleoprotein enzyme composed of an RNA template (hTR) and a catalytically active protein subunit (hTERT), synthesizes telomeres after cell divisions and is obligatory for continuous tumor cell proliferation as well as malignant progression of breast cancer cells. Telomerase is an attractive anti-cancer therapeutic agent because telomerase activity is present in over 90% of human breast cancers but is undetectable in most normal somatic cells. Traditional therapies (surgery, chemotherapy, ... |
|
| Immunology, Systems Biology, and Immunotherapy of Breast Cancer |
MAR 2007 |
18 pages |
| Authors:
Peter P. Lee; STANFORD UNIV CA
|
| This first year of this award has been one of intense infrastructure building. This included recruitment and training of two excellent research associates, two PhD postdoctoral fellows, and one part-time student. I spent several months working closely with Dr. Donna Ferrandino on a human subjects protocol which was approved in August by both the Stanford IRB (protocol ID 4408) and DoD HSRRB (A-13776.2). This enabled us to work closely with ... |
|
| The Use of Cognitive Task Analysis and Simulators for After Action Review of Medical Events in Iraq |
MAR 2007 |
41 pages |
| Authors:
Richard E. Clark; UNIVERSITY OF SOUTHERN CALIFORNIA LOS ANGELES
|
| Prior attempts to use standard "self report" or interview protocols to extract After Action Review (AAR) descriptions of emergency event decision making and problem solving strategies generated by participants are problematical. Cognitive psychological studies suggest that the resulting information often contains significant errors and omissions (Glaser et al., 1985; Besnard, 2000). These errors are not often recognized by participants who solved important problems in emergency situations and wish to give ... |
|
| Artificial Pancreas for Control of BG and Insulin Levels in Hospitalized Patients with Diabetes and Stress Hyperglycemia |
FEB 2007 |
44 pages |
| Authors:
Jeffrey I. Joseph; THOMAS JEFFERSON UNIV PHILADELPHIA PA
|
| This final report describes the data collected to evaluate the performance of two glucose sensor technologies (an interstitial fluid glucose sensor and a vascular glucose sensor) in perioperative surgical patients with diabetes. To date all 10 patient studies specified in the statement of work have been completed. A description of the data and a formal description of the analyses to be preformed are presented herewith. All analyses will be completed ... |
|
| Formulated Delivery of Enzyme/Prodrug and Cytokine Gene Therapy to Promote Immune Reduction of Treated and Remote Tumors in Mouse Models of Prostate Cancer |
JAN 2007 |
127 pages |
| Authors:
Pamela J. Russell; Aparajita Khatri; Yasmin Husaini; Jane Chapman; NEW SOUTH WALES UNIV SYDNEY (AUSTRALIA)
|
| Prostate cancer is the second highest cause of cancer death in men in Western society. Early disease is treatable by surgery or radiation but once late stage disease becomes refractory to hormone removal patient care is limited to pain management. New treatments are needed. We use gene therapy alone and in combination with hormones called cytokines that stimulate the immune system. The concept is that delivering a cell-killing agent to ... |
|
| Skeletal Complications in Neurofibromatosis Type 1: The Role of Neurofibromin Haploinsufficiency in Defective Skeletal Remodeling and Bone Healing in NF1 |
JAN 2007 |
13 pages |
| Authors:
Kevin P. McHugh; BETH ISRAEL DEACONESS MEDICAL CENTER BOSTON MA
|
| A large proportion of patients with Neurofibromatosis Type 1 display skeletal abnormalities including scoliosis and pseudoarthrosis which are compounded by osteoporosis and poor bone healing. Corrective orthopaedic intervention often fails necessitating multiple revision surgeries followed by prolonged recovery periods. The cell types and pathway by which neurofibromin haploinsufficiency (Nf1 +/-) leads to dysregulation of bone remodeling and healing are unknown. The aim of this study is to identify the cell ... |
|
| The Use of Cognitive Task Analysis and Simulators for After Action Review of Medical Events in Iraq |
DEC 2006 |
24 pages |
| Authors:
Richard E. Clark; UNIVERSITY OF SOUTHERN CALIFORNIA REDONDO BEACH BEHAVIORAL TECHNOLOGY LABS
|
| Prior attempts to use standard "self report" or interview protocols to extract After Action Review (AAR) descriptions of emergency event decision making and problem solving strategies generated by participants are problematical. Cognitive psychological studies suggest that the resulting information often contains significant errors and omissions (Glaser et al., 1985; Besnard, 2000). These errors are not often recognized by participants who solved important problems in emergency situations and wish to give ... |
|
| The Meaning of Incontinence and Impotence for Low Income African-American and Latino Men with Prostate Cancer |
DEC 2006 |
16 pages |
| Authors:
Sally L. Maliski; Mark S. Litwin; CALIFORNIA UNIV LOS ANGELES
|
| The purpose of this project is to describe the meaning of prostate cancer treatment-related incontinence and impotence for low income African American and Latino men. Preliminary common categories between the Latino and African American men included erectile dysfunction and incontinence were the price that had to be paid to cure cancer, trusting God as a means of coping, context of incontinence as determinant of its acceptability (e.g. if due to ... |
|
| Proof of Concept for Systematic Collection of Optimal Molecular Quality Anatomically Oriented Normal Prostate from Diverse Age and Race Transplant Donors |
DEC 2006 |
8 pages |
| Authors:
G. S. Bova; JOHNS HOPKINS UNIV BALTIMORE MD SCHOOL OF MEDICINE
|
| The bulk of valuable molecular research published in prostate cancer to date is based on radical prostatectomy specimens from men with prostate cancer, or on metastatic prostate cancer tissues collected at surgery or autopsy. The majority of normal control tissues for such studies come from the same radical prostatectomy specimens, and less commonly from TURP (transurethral resection of the prostate) samples from men with benign prostatic hyperplasia, cystoprostatectomy specimens in ... |
|
| Tissue Factor Plasma Analysis |
NOV 2006 |
32 pages |
| Authors:
Sarah A. Cooley; Kenneth G. Mann; VERMONT UNIV BURLINGTON
|
| This progress report describes the assays, protocols and results related to a collaborative research initiative between Dr. Mann s research laboratories (coagulation research laboratory and Antibody Core Facility, Department of Biochemistry, University of Vermont, Burlington, Vermont) and Dr. Park s clinical research involving trauma and acutely burned patients (U. S. Army Institute of Surgical research, Fort Sam Houston, Texas). The major areas of research involved assessment of the role of ... |
|
| A Smart Video Coding Method for Time Lag Reduction in Telesurgery |
NOV 2006 |
9 pages |
| Authors:
Mingui Sun; Qiang Liu; Jian Xu; Amin Kassam; Sharon E. Enos; Ronald Marchessault; Gary Gilbert; Robert J. Sclabassi; PITTSBURGH UNIV PA DEPT OF ELECTRICAL ENGINEERING
|
| In the future war against terror and new types of offensive activities away from home, telemedical systems, including a telesurgical system, may become standard military medical equipment. In recent years, there have been significant technological advances in both telecommunications and robotics. These advances have made remotely operable telemedicine possible. However, a key technology that rapidly encodes, transmits, and decodes surgical video with the minimum round-trip delay and the least influence ... |
|
| Admission Physiology Criteria After Injury on the Battlefield Predict Medical Resource Utilization and Patient Mortality |
OCT 2006 |
5 pages |
| Authors:
Brian J. Eastridge; Jimmie Owsley; James Sebesta; Alec Beekley; Charles Wade; Robert Wildzunas; Peter Rhee; John Holcomb; ARMY INST OF SURGICAL RESEARCH SAN ANTONIO TX
|
| Medical resources and resource allocation are of prime importance in the modern combat environment. We hypothesized that easily measurable admission physiologic criteria and injury site as well as injury severity calculated after diagnostic evaluation or surgical intervention, would be strongly correlated with resource utilization and in theater mortality outcomes. We retrospectively reviewed the Joint Theater Trauma Registry for all battlefield casualties presenting to surgical component facilities during Operation Iraqi Freedom ... |
|
| Assessment of Risk Reduction for Lymphedema Following Sentinel Lymph Noded Guided Surgery for Primary Breast Cancer |
Oct-2006 |
43 pages |
| Authors:
Andrea L Cheville; PENNSYLVANIA UNIV PHILADELPHIA
|
| Lymphedema is a common complication of primary breast cancer therapy. It is a chronic, insidiously progressive, and potentially devastating condition. Radiation increases patients lymphedema risk as conventional fields encompass functioning lymphatics. Imaging technologies may identify these lymphatics and allow tailoring of radiation fields to minimize radiation exposure while preserving regional tumor control. This study uses SPECT scanning to localize lymphatics critical for arm drainage after surgical removal of axillary lymph ... |
|
| Sage Gene Expression Profiles Characterizing Cure |
OCT 2006 |
61 pages |
| Authors:
William Hrushesy; Phillip Bulkhaults; Shaojin You; DORN RESEARCH INST INC COLUMBIA SC
|
| The timing of breast cancer resection within the estrous cycle of the cycling C3H mouse and the menstrual cycle of the premenopausal woman determines to some extent whether the disease is cured in the mouse and the ten-year disease free survival of the woman. Two metaanalyses have demonstrated the positive effect of timing breast cancer resection as near to midcycle (early luteal phase) as possible. A third study has estimated ... |
|
| Detection of Genetic Alterations in Breast Sentinel Lymph Node by Array-CGH |
OCT 2006 |
28 pages |
| Authors:
Luciane R. Cavalli; GEORGETOWN UNIV WASHINGTON DC
|
| The sentinel lymph node (SLN) is the first node in the mammary gland to harbor malignant cells in breast tumors with metastasis, and SLN positivity is an indication for axillary lymph node dissection. The purpose of our study is to identify specific genetic alterations using array-CGH in the metastatic sentinel lymph node lesions, in comparison to the one observed in the corresponding primary tumors from patients with breast cancer. We ... |
|
| Sentinel Lymph Node Biopsy: Quantification of Lymphedema Risk Reduction |
OCT 2006 |
44 pages |
| Authors:
Andrea L. Cheville; PENNSYLVANIA UNIV PHILADELPHIA
|
| Lymphedema is a common complication of primary breast cancer therapy. It is a chronic, insidiously progressive, and potentially devastating condition. Radiation increases patients lymphedema risk as conventional fields encompass functioning lymphatics. Imaging technologies may identify these lymphatics and allow tailoring of radiation fields to minimize radiation exposure while preserving regional tumor control. This study uses SPECT scanning to localize lymphatics critical for arm drainage after surgical removal of axillary lymph ... |
|
| Joint Medical Semi-Automated Forces (JmedSAF) to Joint Medical Workstation V2 (JMEWS2) Database |
01 SEP 2006 |
12 pages |
| Authors:
Douglas R. Hardy; SPACE AND NAVAL WARFARE SYSTEMS CENTER SAN DIEGO CA
|
| JMedSAF provides medical facility, patient, patient treatment and patient evacuation simulation. The patient conditions (PC), treatment, and evacuation parameters are derived from the Deployable Medical Systems (DEPMEDS) data as defined by the Defense Medical Standardization Board. To support the Cobra Gold Command Post Exercises (CPX), additional patient conditions were created which represent milder forms of the DEPMEDS conditions and disease/non-battle injury distribution data was modified to provide a theater specific ... |
|
| Lymphedema Prophylaxis Utilizing Perioperative Education |
SEP 2006 |
23 pages |
| Authors:
Mary A. Kosir; WAYNE STATE UNIV DETROIT MI
|
| The purpose is to evaluate perioperative training for lymphedema assessment and protection. The hypothesis is that structured perioperative training in lymphedema protection will decrease lymphedema, the episodes of infection, the time to detection of lymphedema and improve the QOL in patients undergoing axillary dissection and/or radiation therapy for breast cancer as compared to a control group. The specific questions (scope) are 1) what is the incidence of lymphedema and infection ... |
|
| Trauma System Development in a Theater of War: Experiences From Operation Iraqi Freedom and Operation Enduring Freedom |
SEP 2006 |
9 pages |
| Authors:
Brian J. Eastride; Donald Jenkins; Stephen Flaherty; Henry Schiller; John B. Holcomb; ARMY INST OF SURGICAL RESEARCH FORT SAM HOUSTON TX
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| Medical lessons learned from Vietnam and previous military conflicts led to the development of civilian trauma systems in the United States. Operation Iraqi Freedom represents the first protracted, large-scale, armed conflict since the advent of civilian trauma systems in which to evaluate a similar paradigm on the battlefield. Collaborative efforts between the joint military forces of the United States initiated development of a theater trauma system in May 2004. Formal ... |
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