| F-16 Ventral Fin Buffet Alleviation Using Piezoelectric Actuators |
Sep-2009 |
122 pages |
| Authors:
Joseph S Browning; AIR FORCE INST OF TECH WRIGHT-PATTERSON AFB OH DEPT OF AERONAUTICS AND ASTRONAUTICS
|
 | Buffet-induced vibrations can have a disastrous impact on aircraft structures. Early attempts at combating buffet vibrations included passive methods such as structural enhancements and leading edge fences. Active methods have shown greater promise, including active airflow control, control surface modulation, and active structural control using piezoelectric actuators. Surface mounted piezoelectric actuators impart directional strain reducing the negative effects associated with harmful vibration. The Block-15 F-16 ventral fin represents an aircraft ... |
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| Numerical Study of Effects of Fluid-Structure Interaction on Dynamic Responses of Composite Plates |
Sep-2009 |
115 pages |
| Authors:
Peter K Kendall; NAVAL POSTGRADUATE SCHOOL MONTEREY CA
|
| Composite materials are seeing increased use in structural applications because of their various benefits. When composite structures are employed in a water environment, their dynamic responses are greatly affected by the fluid medium. Water density is comparable to many composite materials and the effects of fluid-structure interaction on dynamic behaviors of composite structures are significant. The effects of fluid-structure interaction include changes of frequency, magnitude, energy dissipation, etc., of structural ... |
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| A Contrasting Look at Network Formation Models and Their Application to the Minimum Spanning Tree |
Sep-2009 |
66 pages |
| Authors:
Deanne B McPherson; NAVAL POSTGRADUATE SCHOOL MONTEREY CA
|
| Networks are prevalent in man-made and natural systems throughout the world. Despite recent efforts to characterize and catalog networks of all kinds, there is considerably less known about the forces that drive network formation. For many complex systems, it is unclear whether networks are the result of an explicit effort to achieve some overarching global system objective, or if network structure is just a byproduct of local, selfish decisions. In ... |
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| High-Velocity Impact of Low-Density Projectiles on Structural Aluminum Armor |
Sep-2009 |
14 pages |
| Authors:
B R Sorensen; K D Kimsey; B M Love; ARMY RESEARCH LAB ABERDEEN PROVING GROUND MD WEAPONS AND MATERIALS RESEARCH DIRECTORATE
|
| The US Army Research Laboratory has been studying the impact physics of low-density projectiles on urban and light-armor structures for use in electro-magnetic cannons. In this report, results of low-aspect ratio projectiles of nylon, aluminum and steel impacting aluminum armor at velocities above 2000 m/s will be presented. Both computational solid mechanics and analytic modeling techniques were used to supplement experiments to derive a toolkit for assessing target response and ... |
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| Structural Optimization for Blast Mitigation Using HCA |
14-Aug-2009 |
22 pages |
| Authors:
John Goetz; Huade Tan; Andres Tovar; John Renaud; NOTRE DAME UNIV IN
|
| The blast mitigation design problem can be reduced sub problems as given. Each reduc tion in problem formulation feeds backs into the systgem above. Design objecti9ves for each sub problem are selected with the overall problem in mind. |
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| 4th Brigade, 10th Infantry Division Iraqi Army Headquarters Barracks Missan Province, Iraq. Sustainment Assessment |
20-Jul-2009 |
32 pages |
| Authors:
Angelina Johnston; Kevin O'Connor; Todd Criswell; OFFICE OF INSPECTOR GENERAL ARLINGTON VA SPECIAL INSPECTOR GENERAL FOR IRAQ RECONSTRUCTION
|
| The objective of this project assessment was to provide real-time information on relief and reconstruction projects to interested parties to enable appropriate action to be taken, when warranted. Specifically, the Special Inspector General for Iraq Reconstruction (SIGIR) determined whether the project was operating at the capacity stated in the original contract. To accomplish this, SIGIR determined if the project was at full capability or capacity when accepted by the U.S. ... |
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| Structural Performance of Aluminum and Stainless Steel Pyramidal Truss Core Sandwich Panels |
Jul-2009 |
22 pages |
| Authors:
Aristedes Yiournas; Yellapu Murty; Kevin J Doherty; Jordan A Wagner; ARMY RESEARCH LAB ABERDEEN PROVING GROUND MD
|
| Future lightweight military vehicles will demand increasingly mass-efficient structures to satisfy design requirements such as increased mobility and survivability. One possible family of lightweight structures entails sandwich panels consisting of solid facesheets and a low-density core. The sandwich structures can provide both structural strength and stiffness, with load-bearing potential. In this study, sandwich panels consisting of metallic facesheets and a pyramidal truss core manufactured from either 6061-T6 aluminum or 316L ... |
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| Influence of Structural Flexibility on Flapping Wing Propulsion |
Jun-2009 |
180 pages |
| Authors:
Aaron M McClung; AIR FORCE INST OF TECH WRIGHT-PATTERSON AFB OH GRADUATE SCHOOL OF ENGINEERING AND MANAGEMENT
|
| The influence of structural deformations on the aerodynamic response of a flapping wing configuration was examined using Navier-Stokes based simulation. Two deformation modes, torsion and bending, were considered for an elastic axis along the leading edge of the wing. Both deformation modes influence the velocity and acceleration profile of the wing surface, altering the unsteady aerodynamic phenomena produced by the dynamic wing motion. The spanwise feathering rotation, or torsional response, ... |
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| Relaxation Behavior of Ca-Based Bulk Metallic Glasses (Preprint) |
Apr-2009 |
29 pages |
| Authors:
Oleg N Senkov; Daniel B Miracle; UES INC DAYTON OH
|
| Relaxation behavior of Ca60Mg20Zn20, Ca60Mg20Cu20, Ca65Mg15Zn20, Ca50Mg20Cu30, and Ca55Mg18Zn11Cu16 bulk metallic glasses was determined in the glass transition region using DSC with the heating rates from 1 to 160 K/min. The activation enthalpy of structural relaxation and the fragility index m were found to be smaller in the glassy state (onset of the glass transition) than in the supercooled liquid state (end of glass transition). The Ca-based glass-forming liquids showed ... |
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| Environmental Effects on Fatigue Crack Growth in High Performance Aluminum Alloys |
13-Mar-2009 |
6 pages |
| Authors:
J J Williams; N Chawla; ARIZONA STATE UNIV TEMPE
|
| Aluminum alloys are used in a variety of structural applications, such as aircraft wings, fuselage, etc. In addition to cyclic mechanical loads, these alloys are often subjected to aggressive corrosive environments, e.g., salt water and moisture. Thus, a comprehensive understanding of the combined effects of cyclic mechanical loading and environmental effects is necessary. |
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| Least-Squares Finite Element Formulation for Fluid-Structure Interaction |
Mar-2009 |
276 pages |
| Authors:
Cody C Rasmussen; AIR FORCE INST OF TECH WRIGHT-PATTERSON AFB OH GRADUATE SCHOOL OF ENGINEERING AND MANAGEMENT
|
| Fluid-structure interaction problems prove difficult due to the coupling between fluid and solid behavior. Typically, different theoretical formulations and numerical methods are used to solve fluid and structural problems separately. The least-squares finite element method is capable of accurately solving both fluid and structural problems. This capability allows for a simultaneously coupled fluid structure interaction formulation using a single variational approach to solve complex and nonlinear aeroelasticity problems. The least-squares ... |
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| Investigation on the Solubility of GaN in Supercritical Ammonia Containing Acidic, Neutral, and Some Basic Mineralizers |
19-Feb-2009 |
5 pages |
| Authors:
Dirk Ehrentraut; TOHOKU UNIV SENDAI (JAPAN)
|
| The ammonothermal growth technique to fabricate large size (2 inch) gallium nitride (GaN) crystals has recently seen increased interest due to the achievements in the technique published over the last 2-3 years. The first ever 2 inch GaN bulk crystal, to be reported in the April 2009 issue of MRS Bulletin, holds the great promise that ammonothermally produced GaN may become an important GaN substrate material due to the superior ... |
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| Corrosion Inhibiting Chromate-Free Nanocomposite Pretreatments and Nanoparticle Primer Additives for Structural Metals |
05-Feb-2009 |
26 pages |
| Authors:
Fred Allen; NEI CORP SOMERSET NJ
|
| NEI Corporation Spins Out American NanoMyte (Formerly NEI Corrosion Technologies): Experience in developing, manufacturing and distributing nanoscale materials for a broad range of customers around the world * Expertise in nanoparticle synthesis, surface modification and coatings, and nanotechnology-based formulations * Nanomyte line of products, developed by creating nanostructures and modifying them through novel chemistry, fall into two broad categories: ADDITIVES -- Nanomaterials tailored to meet the specific performance and manufacturing ... |
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| Novel Small Molecule Antagonists of the Interaction of the Androgen Receptor and Transcriptional Co-regulators |
Jan-2009 |
34 pages |
| Authors:
Clementine Feau; SAINT JUDE CHILDREN'S RESEARCH HOSPITAL MEMPHIS TN
|
| Androgens, mediated by the Androgen Receptor (AR), play a crucial role in prostate cancer. Current treatments are focused on anti-androgenic drugs competing with natural androgens and antagonizing the transcriptional activity of the AR. Although widely used, these drugs have shown significant side effects and in addition, tumors have become resistant suggesting mutations of the receptor. Regulation of gene expression by AR requires the binding to androgens or to its natural ... |
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| Structure-Activity Relationship Studies on the Mosquito Toxicity and Biting Deterrency of Callicarpenal Derivatives |
Jan-2009 |
13 pages |
| Authors:
James Becnel; Jerome A Klun; Charles L Cantrell; Julia Pridgeon; Green; Solomon III; Frank R Fronczek; MISSISSIPPI UNIV UNIVERSITY
|
| Callicarpenal (=13,14,15,16-tetranorclerod-3-en-12-al=[(1S,2R,4aR,8aR)-1,2,3,4,4a,7,8,8a-octahydro-1,2,4a,5-tetramethylnaphthalen-1-yl]acetaldehyde; 1) has previously demonstrated significant mosquito bite-deterring activity against Aedes aegypti and Anopheles stephensi in addition to repellent activity against host-seeking nymphs of the blacklegged tick, Ixodes scapularis. In the present study, structural modifications were performed on callicarpenal (1) in an effort to understand the functional groups necessary for maintaining and/or increasing its activity and to possibly lead to more effective insect control agents. All modifications in this ... |
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| Structure and Dynamics of End-to-End Loop Formation of the Penta-Peptide Cys-Ala-Gly-Gln-Trp in Implicit Solvents |
Jan-2009 |
10 pages |
| Authors:
Anders Wallqvist; In-Chul Yeh; BIOTECHNOLOGY HPC SOFTWARE APPLICATIONS INST FORT DETRICK MD
|
| To investigate the effects of implicit solvents on peptide structure and dynamics, we performed extensive molecular dynamics simulations on the penta-peptide Cys-Ala-Gly-Gln-Trp. Two different implicit solvent models based on the CHARMM22 all-atom force field were used. Structural properties of the peptide such as distributions of end-to-end distances and dihedral angles obtained from molecular dynamics simulations with implicit solvent models were in a good agreement with those obtained from a previous ... |
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| Prediction of Magnetic and Electronic Phenomena in Molecular-Assembled Crystals |
19-Dec-2008 |
4 pages |
| Authors:
Kyungwha Park; Amy Y Liu; Tunna Baruah; GEORGETOWN UNIV WASHINGTON DC
|
| This grant supported two postdoctoral fellows who worked on a variety of problems related to the prediction of materials properties from first principles. Projects included optimization of a parallel code for calculating magnetic anisotropy parameters; application of the method to molecule-based magnets; studies of structural and electronic properties of interfaces between ferromagnets and semiconductors; and investigation and quantification of vibrational contributions to the Van der Waals interaction between molecules. |
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| PRO-2-PAM: The First Therapeutic Drug for Reactivation of Organo-Phosphate-Inhibited Central (Brain) and Peripheral Cholinesterases |
Dec-2008 |
9 pages |
| Authors:
K; Farhat A Khan; Latoya A Hyson; Angela R Davis; James C DeMar; Ruthie H Ratchiffe; Roberta R Owens; Amy J Campbell; Richard Gordon; Madhusoodana P Nambiar; Elizabeth Marek; WALTER REED ARMY INST OF RESEARCH SILVER SPRING MD
|
| Due to the documented use of organophosphorus (OP) chemical agents in warfare and by terrorists around the globe, Federal, State, and local authorities need novel therapeutics to overcome their deleterious effects. OPs inhibit cholinesterases (ChE), leading to accumulation of the neurotransmitter acetylcholine (ACh). Potentially lethal effects begin with secretion, muscle fasciculation, and paralysis in the peripheral nervous system (PNS). Central nervous system (CNS) perturbations include epileptic seizures leading to neuronal ... |
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| Exploring Structural Bond Energy Release (SBER) in Nanodiamonds Using Quantum Molecular Dynamics and Static High Pressure |
Dec-2008 |
8 pages |
| Authors:
Betsy M Rice; Jennifer A Ciezak; William D Mattson; Radhakrishnan Balu; ARMY RESEARCH LAB ABERDEEN PROVING GROUND MD
|
| We present a combined experimental and theoretical study on carbon nanodiamonds using Raman and DAC experimentation and ab initio calculations. Our calculations confirm the surface reconstruction to a fullerene-like structure, and indicate compression of the diamond core, producing an estimated internal pressure of 50 GPa. Quantum molecular dynamics simulations of hypervelocity collisions of NDs show that upon collision shock-induced amorphization first occurs, followed by complete disruption of the ND surface ... |
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| Allograft Fascia Lata as an Augmentation Device for Musculoskeletal Repairs |
Dec-2008 |
7 pages |
| Authors:
K A Derwin; A Aurora; J P Iannotti; CLEVELAND CLINIC FOUNDATION OH
|
| Musculoskeletal soft tissue injuries during combat are a source of debilitating pain, the treatment and evaluation of which pose a significant challenge to the orthopedic community. Extracellular matrix (ECM) scaffolds derived from various sources and species are being explored for the repair of musculoskeletal tendon injuries. In this paper we demonstrate that amongst these ECM scaffolds, only tensor fascia lata has structural and tensile material properties comparable to tendon, but ... |
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| An In Vitro Skin Equivalent for Evaluation of Skin Absorption of Compounds |
Dec-2008 |
9 pages |
| Authors:
Priya Batheja; Bozena Michniak; Prafulla Chandra; Vishwas Rai; RUTGERS - THE STATE UNIV PISCATAWAY NJ ERNEST MARIO SCHOOL OF PHARMACY
|
| Skin Equivalents (SE) or Human Skin Equivalents (HSEs) are skin substitutes that can serve as models for testing the skin permeability of agents from formulations, or for evaluation of formulations themselves on the skin. We have developed a collagen based HSE and HSE containing electrospun poly(DTE carbonate) polymer scaffolds in our laboratory. The culture of these full thickness skin equivalents has been optimized by modification of the culture media and ... |
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| Unique Stealth Unmanned Aerial Vehicle (UAV) Houck Aircraft Design Program. Volume 2: Prototype Report |
Nov-2008 |
149 pages |
| Authors:
Timothy Fry; DAYTON UNIV OH
|
| This report covers the collaborative activities conducted under the leadership of the University of Dayton Research Institute on the Unique Stealth Unmanned Aerial Vehicle (UAV) Houck Aircraft Design Program. This was organized in five phases: aerodynamic evaluation of 6-inch model; aerodynamic evaluation of 24-inch model; design exploration for the Preferred System Concept; design of Preferred System Concept; and fabrication of flying prototype aircraft. Overall, this configuration, as modeled, was found ... |
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| Extrinsic Substrate Orientation Dependence of Ferromagnetism in (Ga,Mn)As Digital Ferromagnetic Heterostructures |
01-Oct-2008 |
13 pages |
| Authors:
M J Wilson; G Xiang; B L Sheu; P Schiffer; N Samarth; PENNSYLVANIA STATE UNIV UNIVERSITY PARK OFFICE OF SPONSORED PROGRAMS
|
| We describe the structural and magnetic properties of digital ferromagnetic heterostructures of (Ga,Mn)As grown on (001), (311), (201) and (110) GaAs surfaces. Our measurements show a systematic variation of the Curie temperature with epitaxial orientation for samples with a nominally identical structure. Control measurements of randomly alloyed (Ga,Mn)As grown on these substrates show identical trends in Curie temperature, suggesting that the substrate orientation plays a strong role in the formation ... |
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| Multifunctional Properties of Structural Gel Electrolytes |
01-Sep-2008 |
18 pages |
| Authors:
P-A T Nguyen; J F Snyder; ARMY RESEARCH LAB ABERDEEN PROVING GROUND MD WEAPONS AND MATERIALS RESEARCH DIRECTORATE
|
| Multifunctional structural gel electrolytes were prepared by the integration of conductive pathways using non-aqueous solvents into structural resin networks. Poly(ethylene) glycol (200 MW) and propylene carbonate were used as non-aqueous solvents while vinyl ester and epoxy resin were used as structural resins. The monomer and solvents were incorporated together and polymerized to create conductive pathways is crosslinked networks. THe impact of chemistry and weight fraction of both liquid and resin ... |
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| Team Collaboration of the Northeast Air Defense Sector and Federal Aviation Administration during the September 11, 2001 Attacks |
01-Sep-2008 |
177 pages |
| Authors:
Luis F Socias; NAVAL POSTGRADUATE SCHOOL MONTEREY CA
|
| The tragic events of September 11, 2001, brought about changes in the procedures for interagency collaboration. That day air traffic controllers in New York, Boston, Washington, and Cleveland were scrambling due to the hijacking of four American commercial airliners. In their efforts to bring order to chaos the Federal Aviation Administration (FAA) in communication with Northeast Air Defense Sector (NEADS) and North American Aerospace Defense Command (NORAD) scrambled fighter aircraft ... |
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| Diamond-Like and Self-Assembling Organic Nanostructures: Measurement and Simulation of Intermolecular Interactions and Structural Characteristics |
Sep-2008 |
6 pages |
| Authors:
Guoping Zhang; Thomas F George; Lahsen Assoufid; G A Mansoori; MISSOURI UNIV-ST LOUIS
|
| Our experimental and theoretical objectives have focused on adamantane, the first diamondoid. This compound gives us substantial detailed information about the interaction between carbon-carbon, carbon-hydrogen, and hydrogen-hydrogen atoms. This has provided a first test case for the theoretical teams at the University of Missouri-St. Louis and Indiana State University to accurately measure and compute the electronic structure and mechanical properties. The results have been compared with the existing model potentials, ... |
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| Evaluation of Impact Mitigation and Health Monitoring Tradeoffs in Composite Missile Casing Design Using Iterative Inversion Loads and Damage Identification Methods |
26-Jul-2008 |
14 pages |
| Authors:
Douglas E Adams; Jonathan White; Nick Stites; Nathan Yoder; Carlos Escobar; PURDUE UNIV LAFAYETTE IN
|
| Sensing, modeling, and data analysis techniques for health monitoring of composite missile casings (carbon filament wound and S2 glass filament wound) have been developed. Here, the term health monitoring is used to refer to both loads identification and damage identification for the purpose of assessing the material state and structural performance of a missile casing pressure vessel. Impact loads were located and quantified using a single sensor without a detailed ... |
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| Al Ager Water Compact Unit, Nassriya, Iraq |
22-Jul-2008 |
24 pages |
| Authors:
Angelina Johnston; Todd Criswell; OFFICE OF INSPECTOR GENERAL ARLINGTON VA SPECIAL INSPECTOR GENERAL FOR IRAQ RECONSTRUCTION
|
| The Special Inspector General for Iraq Reconstruction initiated this project assessment as part of its continuing assessments of selected activities of the Economic Support Fund. SIGIR conducted this project assessment in accordance with the Quality Standards for Inspections issued by the President's Council on Integrity and Efficiency. The assessment team included a professional engineer/inspector and an auditor/inspector. |
|
| 33-Kilovolt Power Line, Nassriya, Iraq |
22-Jul-2008 |
24 pages |
| Authors:
Angelina Johnston; Todd Criswell; OFFICE OF INSPECTOR GENERAL ARLINGTON VA SPECIAL INSPECTOR GENERAL FOR IRAQ RECONSTRUCTION
|
| The Special Inspector General for Iraq Reconstruction initiated this project assessment as part of its continuing assessments of selected activities of the Economic Support Fund. SIGIR conducted this project assessment in accordance with the Quality Standards for Inspections issued by the President's Council on Integrity and Efficiency. The assessment team included a professional engineer/inspector and an auditor/inspector. |
|
| ORA User's Guide 2008 |
01-Jul-2008 |
589 pages |
| Authors:
Jeff Reminga; Il-Chul Moon; Matt DeReno; Kathleen M Carley; Dave Columbus; CARNEGIE-MELLON UNIV PITTSBURGH PA SCHOOL OF COMPUTER SCIENCE
|
| ORA is a network analysis tool that detects risks or vulnerabilities of an organization's design structure. The design structure of an organization is the relationship among its personnel, knowledge, resources, and tasks entities. These entities and relationships are represented by the Meta-Matrix. Measures that take as input a Meta-Matrix are used to analyze the structural properties of an organization for potential risk. ORA contains over 100 measures which are categorized ... |
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| Mechanistic Basis of Calmodulin Mediated Estrogen Receptor Alpha Activation and Antiestrogen Resistance |
01-Jun-2008 |
38 pages |
| Authors:
Jeffrey L Urbauer; GEORGIA UNIV ATHENS
|
| Estrogen receptor alpha (ERa) is the principle chemotherapeutic target for estrogen dependent breast cancers. Calmodulin (CaM) is an obligatory ERa activator. Moreover, antiestrogens (tamoxifen) bind tightly to CaM, and some therapeutic benefits of antiestrogens for breast cancers are hypothesized to derive from this interaction. The purpose and scope of the research is to define the structural requisites of ERa activation by CaM and the relationship between tamoxifen binding to CaM, ... |
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| Identification of Adversarial Activities: Profiling Latent Uses of Facilities from Structural Data and Real-time Intelligence |
01-Jun-2008 |
33 pages |
| Authors:
Georgiy M Levchuk; Darby E Grande; E W Stacy; APTIMA INC WOBURN MA
|
| Intelligence Preparation of the Battlefield (IPB) provides critical support for military planning and decision making. In both offensive and defensive operations, the IPB process gives a decision maker information about the enemy, including potential courses of action, as well as information about the environment in which he is working. Physical structures that can support repetitive crimes (such as IED supply chains or illegal drug trafficking) provide important information for C2 ... |
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| Evaluation of Nanocomposites as Lightweight Electronic Enclosures for Satellites' Applications |
JUN 2008 |
98 pages |
| Authors:
Benjamin T. Harder; AIR FORCE INST OF TECH WRIGHT-PATTERSON AFB OH SCHOOL OF ENGINEERING AND MANAGEMENT
|
| The United States military is exploring the use of nanocomposite materials for satellite structural applications. Current composite spacecraft structures are nonconductive and must have expensive shielding materials applied in order to protect the spacecraft from catastrophic damage that can be caused by electromagnetic interference (EMI) and/or electrostatic discharge (ESD) which are characteristics of the space environment. Conductive nanocomposites are being developed for spacecraft structures that will provide ESD and EMI ... |
|
| Multi-scale Modeling of Proton Transport, Water Distribution, and Methanol Permeability in Proton Exchange Membranes (PEMs) |
26-May-2008 |
9 pages |
| Authors:
Stephen J Paddison; Mark E Tuckerman; ALABAMA UNIV IN HUNTSVILLE
|
| We have undertaken our multiscale modeling of proton exchange membranes through three simultaneous but distinct studies of perfluorosulfonic acid (PFSA) systems at different time and length scales: (1) hydrated morphology of PFSA membranes with dissipative particle dynamics (DPD) simulations; (2) classical MD simulations of the hydration and hydronium ion diffusion of the short-side chain (SSC) PFSA membrane; and (3) ab initio density functional theory Car-Parrinello MD simulations of model PFSA ... |
|
| Mass Spectral Fragmentation of VX |
MAY 2008 |
31 pages |
| Authors:
Dennis K. Rohrbaugh; EDGEWOOD CHEMICAL BIOLOGICAL CENTER ABERDEEN PROVING GROUND MD
|
| The objective of this study was to provide structural identification of VX fragment ions formed during mass spectrometric analysis, elucidation of fragmentation pathways, and a compilation of tandem mass spectral product ion spectra to aid in detection and confirmation of trace levels of VX in complex matrices. Fragmentation was observed and is reported here for both electron ionization and chemical ionization (methane) conditions. Isotopic labeling analysis using d5-VX was performed ... |
|
| Multiplex Quantitative Histologic Analysis of Human Breast Cancer Cell Signaling and Cell Fate |
MAY 2008 |
7 pages |
| Authors:
William M. Lee; Badrinath Roysam; PENNSYLVANIA UNIV PHILADELPHIA
|
| Many molecular events and cellular processes are preserved in fixed human tumor specimens, and access to this wealth of information about human cancers in authentic context awaits a method for them to be quantified and analyzed. Some, such as cell signaling and cell fate decisions, are prognostically and therapeutically important, and can be revealed by immunohistological staining. We are developing a novel platform for immunohistological study of breast cancer specimens ... |
|
| Characterize RAP80, a Potential Tumor Suppressor Gene |
01-Apr-2008 |
18 pages |
| Authors:
Xiaochun Yu; MICHIGAN UNIV ANN ARBOR
|
| To examine the molecular mechanism by which BRCA1 participates in breast tumor suppression we have identified that RAP8O is a BRCA1-associated protein by protein affinity purification. Here we show the evidence that RAP8O controls BRCA1's relocation to DNA damage sites and regulates BRCA1-dependent DNA damage checkpoint function. In addition we have identified a truncation mutation of RAP8O in an ovarian cancer cell line. Thus our results indicate that RAP8O is ... |
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| Harnessing Novel Secreted Inhibitors of EGF Receptor Signaling for Breast Cancer Treatment |
01-Apr-2008 |
64 pages |
| Authors:
Mark A Lemmon; PENNSYLVANIA UNIV PHILADELPHIA
|
| We aim to develop protein therapeutics that neutralizes growth factors that activate EGF receptor family members in breast cancer. Rather than targeting receptors themselves (as do Herceptin, Iressa, etc), we propose to target the activating ligands. Our model is Argos from Drosophila, which we showed naturally, inhibits EGF receptor signaling in fruit flies by inactivating the ligand. We hope to effectively humanize Argos - making it bind human EGFR ligands ... |
|
| A New Computational Methodology for Structural Dynamics Problems |
APR 2008 |
62 pages |
| Authors:
J. N. Reddy; TEXAS A AND M UNIV COLLEGE STATION DEPT OF MECHANICAL ENGINEERING
|
| Most structural components encountered in army vehicles and armor can be classified as beams, plates, or shells for analysis purposes. While these structural elements are designed to function properly under thermo-mechanical loads encountered in their use, they do develop high stresses and experience high vibration frequencies that may make them non-functional in actual service conditions. The objective of this research is to develop consistent plate and shell theories and associated ... |
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| Structural Health Monitoring of a Bonded Composite Patch Repair on a Fatigue-Cracked F-111C Wing |
01-Mar-2008 |
|
| Authors:
Alan Baker; DEFENCE SCIENCE AND TECHNOLOGY ORGANISATION VICTORIA (AUSTRALIA) AIR VEHICLES DIV
|
 | A large fatigue crack in the wing skin of an Australian Defence Force F-111C aircraft was repaired with an adhesively bonded boron/epoxy fibre composite patch. The patch prevented further growth of the crack for 670 flying hours. To aid in the continued safe operation of ADF F-111 aircraft, a decision was later made to assess the residual life of the F-111 wings in part by undertaking a fatigue test at ... |
|
| Design and Response of a Structural Multifunctional Fuel Cell |
MAR 2008 |
34 pages |
| Authors:
Joseph South; Daniel Baechle; Corydon Hilton; Daniel DeSchepper; Eric Wetzel; ARMY RESEARCH LAB ABERDEEN PROVING GROUND MD WEAPONS AND MATERIALS RESEARCH DIRECTORATE
|
| Many U.S. Army systems, such as ground vehicles and fully equipped Soldiers, are comprised of multiple subcomponents which each typically perform unique functions. Combining these functions into a single, multifunctional component may reduce mass and improve overall system efficiency. Of particular interest are structural materials that also provide power- generating or energy-storing capacity and could provide significant weight savings over a range of platforms. In this study, structural fuel cells ... |
|
| Combined High Temperature Aerothermal-Structural Physical Property Testing of Ceramic Matrix Composites |
MAR 2008 |
19 pages |
| Authors:
Don E. King; David G. Drewry; JOHNS HOPKINS UNIV LAUREL MD APPLIED PHYSICS LAB
|
| The objective was to integrate a mechanical test apparatus into a wind tunnel flow field capable of generating controlled multi-directional stress/strain states in flat coupons exposed to appropriate chemical, thermal, and aerodynamic shear flow environments. Displacement control enables imposition of stress/strain fields (in the flat coupons) similar to those expected in complex flight component geometries. Control and measurement of these variables and the material response in a controlled environment enables ... |
|
| Determination of the Dynamics, Structure, and Orientation of the Transmembrane Segment of ErbB2 in Model Membranes Using Solid-State NMR Spectroscopy |
MAR 2008 |
9 pages |
| Authors:
Elvis K. Tiburu; BETH ISRAEL DEACONESS MEDICAL CENTER BOSTON MA
|
| The objective of the proposed research was to investigate the structural properties of the transmembrane helix of the ErbB2 receptor utilizing solid-state nuclear magnetic resonance (NMR) spectroscopy and Molecular dynamics (MD) simulations. 15N Solid-state NMR results demonstrated that TM-ErbB2 has a transmembrane helical domain and that the orientation of the transmembrane domain is 24 5 in shorter chain dimyristoylphosphocholine and 11 3 in palmitoyloleoyphosphocholine. The orientation is dictated by the ... |
|
| Damage Detection Analysis Using Lamb Waves in Restricted Geometry for Aerospace Applications |
MAR 2008 |
83 pages |
| Authors:
Roman T. Underwood; AIR FORCE INST OF TECH WRIGHT-PATTERSON AFB OH GRADUATE SCHOOL OF ENGINEERING AND MANAGEMENT
|
| A goal of structural health monitoring (SHM) is to increase aircraft readiness through condition based maintenance (i.e. servicing an aircraft only when it is known to be necessary). The lead ziconate titanate (PZT) is a commonly used piezoelectric transducer that has shown potential to detect damage in aircraft structures without time consuming manual inspections. But many locations identified by the USAF for SHM have restricted geometries, presenting difficulties using the ... |
|
| An Experimental Technique for Developing Intermediate Strain Rates in Ductile Metals |
MAR 2008 |
194 pages |
| Authors:
IV Gardenier Hugh E.; AIR FORCE INST OF TECH WRIGHT-PATTERSON AFB OH GRADUATE SCHOOL OF ENGINEERING AND MANAGEMENT
|
| Quantifying the strain-rate sensitive dynamic properties of structural materials is an important area of research in the solid mechanics field. Property evaluation is typically accomplished using dynamic tests which involve rapid loading or impact of specimens. In these tests, inertial forces and wave propagation make it difficult to accurately record the material response to a loading condition at an equivalent location. Furthermore, these tests typically generate high strain rates (in ... |
|
| Investigation of the Transmission of Sound Through Isotropic, Damped Material Layer(s) Bounded by Seawater |
MAR 2008 |
69 pages |
| Authors:
Gerald J. Roche; NAVAL POSTGRADUATE SCHOOL MONTEREY CA
|
| Acoustic 'windows' are used in SONAR applications to absorb structural loads associated with the platform operation while allowing the passage of acoustic signals. The performance metric commonly used to gauge the acoustic window quality is insertion loss. This thesis provides a derivation of insertion loss for multi-layered materials as a function of frequency and angle of incidence. Derivations are modified to include attenuation of the signals in the material and ... |
|
| Nonlinear Stochastic Flutter of a Cantilever Wing with Joint Relaxation and Random Loading |
21 FEB 2008 |
152 pages |
| Authors:
Raouf A. Ibrahim; Ronald F. Gibson; WAYNE STATE UNIV DETROIT MI DEPT OF MECHANICAL ENGINEERING SCIENCES
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| The research project has generated a number of problems addressing the uncertainties and relaxation problems in aeroelastic structures. Specifically, three main problems that are of important concern to the aerospace industry and the Air Force technology have been addressed. These are: (1) The influence of structure uncertainties of the flutter of an aircraft wing. (2) Stabilization of wing flutter via parametric excitation. (3) Influence ofjoint relaxation on the flutter of ... |
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| Remote Structural Monitoring and Corrosion Degradation Modeling of Bridges |
14-Feb-2008 |
20 pages |
| Authors:
Vincent Hock; Richard Lampo; Steven Sweeny; ENGINEER RESEARCH AND DEVELOPMENT CENTER CHAMPAIGN IL CONSTRUCTION ENGINEERING RESEARCH LAB
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| Bridges are essential infrastructure. Many Army and DoD bridges in need of repair and replacement due to corrosion/material degradation. Over 11-year period, 503 U.S. bridges failed, 100 of these due to corrosion. Routine inspection may not detect hidden cracks and avoid catastrophic failure. The objectives of these briefing charts are to demonstrate capabilities and validate benefits of remote structural health monitoring and corrosion degradation modeling to greatly reduce the risk ... |
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| Novel Concepts for Conformal Load-Bearing Antenna Structure |
01-Feb-2008 |
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| Authors:
Paul J Callus; DEFENCE SCIENCE AND TECHNOLOGY ORGANISATION VICTORIA (AUSTRALIA) AIR VEHICLES DIV
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| This report describes the activities undertaken by the author during his Defence Science Fellowship on the topic of Conformal Load-bearing Antenna Structure (CLAS) at the Air Force Research Laboratory, Air Vehicles Directorate, Structures Division, Advanced Structural Concepts Branch (AFRL/VASA), Multifunctional Structures Team at the Wright Patterson Air Force Base, Ohio, USA, from June 2006 to August 2007. The aim of CLAS is to enhance the performance and capability of air ... |
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| Structural Studies on Intact Clostridium botulinum Neurotoxins Complexed with Inhibitors Leading to Drug Design |
FEB 2008 |
7 pages |
| Authors:
Subramanyam Swaminathan; BROOKHAVEN NATIONAL LAB UPTON NY
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| This is an annual report in no cost extension period. In this period we have identified several compounds via virtual screening. These compounds include small molecules transition state analogues and benzimidazoles. We have determined the crystal structure of BoNT/E with the substrate tetra peptide containing the scissile bond. |
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