| Remote Sensing Plant Stress Using Combined Fluorescence and Reflectance Measurements for Early Detection of Defoliants within the Battlefield Environment |
02 Oct 2012 |
10 pages |
| Authors:
Donald R Young; VIRGINIA COMMONWEALTH UNIV RICHMOND
|
 | Leaf fluorescence spectral characteristics were fused with reflectance hyperspectral data to remotely sense vegetation/terrain conditions. Field measurements were conducted at the Virginia Coast Reserve, NSF, long-term ecological research site and at Ft. A.P. Hill. Laboratory experiments and field measurements incorporated relevant battlefield contaminants and natural environmental stresses. Goals were to 1) link leaf fluorescence and reflectance patterns and plant physiological responses with different kinds and degrees of environmental stress, 2) ... |
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| Ketamine as a Rapid Treatment for Post-Traumatic Stress Disorder |
Oct 2012 |
5 pages |
| Authors:
Dennis Charney; Adriana Feder; MOUNT SINAI SCHOOL OF MEDICINE NEW YORK
|
| Post-traumatic stress disorder (PTSD) is a debilitating anxiety disorder characterized by intrusive re-experiencing of the traumatic events, avoidance of situations and stimuli that could serve as reminders of these events, and chronic hypervigilance. Patients with PTSD are often also depressed, and many have significant memory impairments. In the present study, we expect a single ketamine infusion to reduce core PTSD symptoms. In addition, in those patients with PTSD who are ... |
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| On the Behaviour of Porcine Adipose and Skeletal Muscle Tissues under Shock Compression |
Sep 2012 |
244 pages |
| Authors:
James M Wilgeroth; CRANFIELD UNIV (UNITED KINGDOM)
|
| The response of porcine adipose and skeletal muscle tissues to shock compression has been investigated using the plate-impact technique in conjunction with manganin foil pressure gauge diagnostics. This approach has allowed for measurement of the levels of uniaxial stress imparted to both skeletal muscle and rendered adipose tissue by the shock. In addition, the lateral stress component generated within adipose tissue during shock loading has also been investigated. The techniques ... |
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| Effect of Intraperitoneal Radiotelemetry Instrumentation on Voluntary Wheel Running and Surgical Recovery in Mice |
Sep 2012 |
10 pages |
| Authors:
Bryan G Helwig; Jermaine A Ward; Michael D Blaha; Lisa R Leon; ARMY RESEARCH INST OF ENVIRONMENTAL MEDICINE NATICK MA THERMAL AND MOUNTAIN MEDICINE DIVISION
|
| Radiotelemetry transmitters support tracking of physiologic variables in conscious animals, but the size of the transmitter may alter animal health and behavior. We hypothesized that the size of the device adversely affects body weight, food intake, water intake, circadian core temperature, activity, voluntary running patterns, and the health of internal organs and that these negative effects can be minimized with smaller transmitter devices. Male C57BL/6J mice (weight, 20 to 24 ... |
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| Characterizing and Targeting Replication Stress Response Defects in Breast Cancer |
Aug 2012 |
24 pages |
| Authors:
Shiaw-Yih Lin; Chun-Jen Lin; Edward Wang; Hui Dai; Ju-Seog Lee; Chun Li; M D ANDERSON CANCER CENTER HOUSTON TX
|
| During the second year of this project, we have made significant progress in several of our proposed tasks. We found that both TUSC4 and PRMT5 may function as RSR genes through their activities in facilitating HR DNA repair. Both TUSC4 and PRMT5 inhibit cell proliferation and cellular transformation, and may function as potential tumor suppressor genes in breast cancer. DNA2 is also involved in HR repair in response to RSR. ... |
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| Investigating Clinical Benefits of a Novel Sleep-focused Mind-body Program on Gulf War Illness Symptoms: An Exploratory Randomized Controlled Trial |
Jul 2012 |
4 pages |
| Authors:
Yoshio Nakamura; UTAH UNIV SALT LAKE CITY
|
| Subjects are being recruited for the proposed study and the study is still ongoing. Thus, there is no finding to report from the study as of 30/06/2012. |
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| Combat, Sexual Assault, and Post-Traumatic Stress in OIF/OEF MilitaryWomen |
Jul 2012 |
25 pages |
| Authors:
Anne G Sadler; IOWA CITY VA MEDICAL CENTER IA
|
| This research addresses DoD and DV A health care delivery needs of two priority populations: women exposed to combat, and women sexually assaulted during military. There is a limited understanding of the complex relationship between these traumatic exposures and women's health outcomes, such as post-traumatic stress disorder (PTSD) and traumatic brain injury (TBI) and with their subsequent health service use or barriers to care. Objective(s): The objectives of this study ... |
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| Function and Regulation of Vibrio campbellii Proteorhodopsin: Acquired Phototrophy in a Classical Organoheterotroph |
Jun 2012 |
10 pages |
| Authors:
Zheng Wang; Thomas J O'Shaughnessy; Carissa M Soto; Amir M Rahbar; Kelly L Robertson; Nikolai Lebedev; Gary J Vora; NAVAL RESEARCH LAB WASHINGTON DC CENTER FOR BIOMOLECULAR SCIENCE AND ENGINEERING
|
| Proteorhodopsins (PRs) are retinal-binding photoproteins that mediate light-driven proton translocation across prokaryotic cell membranes. Despite their abundance, wide distribution and contribution to the bioenergy budget of the marine photic zone, an understanding of PR function and physiological significance in situ has been hampered as the vast majority of PRs studied to date are from unculturable bacteria or culturable species that lack the tools for genetic manipulation. In this study, we ... |
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| Human Factor Assessment in Support of Joint Operations |
04 May 2012 |
29 pages |
| Authors:
Roy Hoffman; NAVAL WAR COLL NEWPORT RI JOINT MILITARY OPERATIONS DEPT
|
| Human factors, including personal, psychological, and physical stressors, can strain members of the force and precipitate adverse incidents that may impair operational effectiveness and jeopardize force protection. To mitigate that risk, operational commanders charged simultaneously to accomplish the mission and ensure force protection need accurate, timely information regarding human factors that can potentially impinge on service member performance or judgment. Toward that end, the U.S. Naval Aviation community and the ... |
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| How Do the Metabolic Effects of Chronic Stress Influence Breast Cancer Biology? |
Apr 2012 |
34 pages |
| Authors:
Paul Volden; CHICAGO UNIV IL
|
| In the C3(1)/SV40 T-antigen (Tag) FVB/N mouse model of human estrogen and progesterone receptor-negative breast cancer, the stress response elicited by social isolation is associated with increased expression of metabolic genes in the mammary gland. To further understand accelerated tumor growth associated with social isolation, we separated mammary gland adipocytes from ductal epithelium and stroma and then analyzed individual fractions for changes in metabolic gene expression and function. The increased ... |
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| Novel Role of Merlin Tumor Suppressor in Autophagy and its Implication in Treating NF2-Associated Tumors |
Apr 2012 |
7 pages |
| Authors:
Toshifumi Tomoda; Jr Jhung Donald; Yuki Hirota; CITY OF HOPE BECKMAN RESEARCH INST DUARTE CA
|
| The overall goal of the proposed research is to elucidate the novel function of Merlin in autophagy, a cellular catabolic pathway implicated in tumorigenesis, and to control the Merlin-mediated tumorigenesis by modulating cellular autophagy. We have recently demonstrated that Merlin binds an autophagy regulator protein, and that loss of Merlin leads to attenuated autophagy as well as enhanced hypoxia or metabolic stress in the three-dimensional (3D) microenvironment in culture, a ... |
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| The Separate and Cumulative Effects of TBI and PTSD on Cognitive Function and Emotional Control |
Apr 2012 |
98 pages |
| Authors:
Diane Swick; CALIFORNIA UNIV DAVIS
|
| Combat veterans who have sustained a traumatic brain injury (TBI) can show impairments in behavioral and cognitive control and increases in impulsivity. In addition, many with mild TBI will also have post-traumatic stress disorder (PTSD). To improve diagnostic capabilities and better define treatment alternatives, it is important to determine the unique (and shared) contributions of each disorder to deficits in cognitive function and emotional control. Three specific control functions are ... |
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| Dietary Intake and Stress Fractures Among Elite Male Combat Recruits |
13 Mar 2012 |
15 pages |
| Authors:
Daniel S Moran; Yuval Heled; Yael Arbel; Eran Israeli; Aharon Finestone; Rachel K Evans; Ran Yanovich; ARMY RESEARCH INST OF ENVIRONMENTAL MEDICINE NATICK MA MILITARY PERFORMANCE DIV
|
| Appropriate and sufficient dietary intake is one of the main requirements for maintaining fitness and health. Inadequate energy intake may have a negative impact on physical performance which may result in injuries among physically active populations. The purpose of this research was to evaluate a possible relationship between dietary intake and stress fracture occurrence among combat recruits during basic training (BT). |
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| Glottal Waveform Analysis of Physical Task Stress Speech (Preprint) |
Mar 2012 |
5 pages |
| Authors:
Keith W Godin; Taufiq Hasan; John H Hansen; RESEARCH ASSOCIATES FOR DEFENSE CONVERSION(RADC) MARCY NY
|
| Physical task stress affects the acoustic speech wave in various ways. Motivated by observations that fundamental frequency and open quotient are affected by physical task stress, this study examines the effects of physical task stress on parameters of the estimated glottal volume velocity waveform. It is shown that, in contrast to other types of phonation such as soft, loud, breathy, or pressed voice, physical task stress has little effect on ... |
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| Oxidative Stress Increases the Blood Brain Barrier Permeability Resulting in Increased Incidence of Brain Metastasis in BRCA Mutation Carriers |
Feb 2012 |
7 pages |
| Authors:
Hava Avraham; BETH ISRAEL DEACONESS MEDICAL CENTER BOSTON MA
|
| BRCA1 is a multifunctional tumor suppressive protein. Knockout of WT BRCA1 in breast cancer cells resulted in an increase in cell proliferation, anchorage-independent growth, cell migration, invasion and a loss of p21/Waf1 and P27Kip1 expression. In BRCA1 knocked-down cells, the expression of survivin was significantly up regulated with a decrease in cellular sensitivity to paclitaxel. Cells that harbor endogenous mutant or defective BRCA1 (such as MDA-MB-436 and HCC1937) were highly ... |
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| Defense Health: Coordinating Authority Needed for Psychological Health and Traumatic Brain Injury Activities |
Jan 2012 |
59 pages |
| Authors:
GOVERNMENT ACCOUNTABILITY OFFICE WASHINGTON DC
|
| Post-traumatic stress disorder (PTSD), which falls into the broader field of psychological health (PH), and traumatic brain injury (TBI) are recognized as the signature wounds of the wars in Afghanistan and Iraq. In two reports issued in 2011 (GAO-11-219 and GAO-11-611), GAO cited numerous management weaknesses at the Defense Center of Excellence for PH and TBI (DCOE). For the present report, GAO reviewed (1) funding for DOD's PH and TBI ... |
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| Assessing Beaked Whale Reproduction and Stress Response Relative to Sonar Activity at the Atlantic Undersea Test and Evaluation Center (AUTEC) |
Jan 2012 |
12 pages |
| Authors:
Diane E Claridge; Nick Kellar; John W Durban; BAHAMAS MARINE MAMMAL RESEARCH ORGANISATION ABACO (BAHAMAS)
|
| Atypical mass strandings and behavioral responses of beaked whales have been correlated with exposure to naval sonar (e.g. Simmonds and Lopez-Juraco 1991; Frantzis 1998; Evans and England 2001), highlighting a need to understand the potential physiological impacts to individual whales and if these in turn represent a biologically significant threat to exposed populations. The long-term goal of this study is to assess glucocorticoid levels from blubber biopsies of targeted species, ... |
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| Review of Stress and the Measurement of Stress in Marine Mammals |
Jan 2012 |
3 pages |
| Authors:
John Cockrem; MASSEY UNIV PALMERSTON NORTH (NEW ZEALAND)
|
| The objectives are to comprehensively review the literature on stress in cetaceans, stress in pinnipeds and stress in other marine mammals, and to devise and present a conceptual framework for considering stress in marine mammals that can be used by marine mammal researchers to consider how animals detect and respond to stressors over short and longer time periods. Summary tables will be prepared to list, for each group of marine ... |
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| Applying Neuroscience to Enhance Tactical Leader Cognitive Performance in Combat |
16 Dec 2011 |
111 pages |
| Authors:
Andrew C Steadman; ARMY COMMAND AND GENERAL STAFF COLL FORT LEAVENWORTH KS
|
| The U.S. Army relies on tactical-level leaders not for their physical warfighting skills, but for their ability to employ cognitive thought during stressful situations. Cognitive tasks include sensing patterns, deciphering complex environments, creating novel solutions, and synchronizing multiple battlefield systems, to name but a few. The physiological response to combat can degrade that cognitive capability, preventing leaders from performing tasks critical to unit success. This thesis approached tactical combat leadership ... |
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| Analysis of Citalopram and Desmethylcitalopram in Postmortem Fluids and Tissues Using Liquid Chromatography-Mass Spectrometry |
Oct 2011 |
16 pages |
| Authors:
Russell J Lewis; Mike K Angier; Robert D Johnson; Brittany M Rains; Sarik Nepal; FEDERAL AVIATION ADMINISTRATION OKLAHOMA CITY OK CIVIL AEROSPACE MEDICAL INST
|
| Citalopram is a selective serotonin reuptake inhibitor that is a commonly prescribed drug for the treatment of depression, obsessive-compulsive disorder, panic disorder, anxiety disorder, and post-traumatic stress disorder. While the use of citalopram is relatively safe, certain side effects could negatively affect a pilot s performance and become a factor in an aviation accident. The side effects of this medication include nausea, tiredness, drowsiness, dizziness, and blurred vision. Due to ... |
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| Applying Genomic and Genetic Tools to Understand and Mitigate Damage from Exposure to Toxins |
Oct 2011 |
14 pages |
| Authors:
Richard Myers; Kelly T Williams; HUDSONALPHA INST FOR BIOTECHNOLOGY HUNTSVILLE AL
|
| Use of the pyridostigmine bromide during the 1991 Gulf War has been implicated as a contributing factor for increased risk of Gulf War Illness (GWI). Stress and genetic factors are postulated to modulate the effects of PB. We have proposed to use mRNA-seq to study the response to PB exposure and modulating factors, using zebrafish as a model organism. In the past year, we have studied the dose-response to PB ... |
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| Developing Treatment, Treatment Validation & Treatment Scope in the Setting of an Autism Clinical Trial |
Oct 2011 |
14 pages |
| Authors:
T P Stein; UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY PISCATAWAY
|
| We obtained IRB approval on December 7th ., 2009.. We applied for and received a COC from the NIH as required and received final approval from our IRB on March 25th 2010. The test material DHA and the placebo were acquired from Martek with a significant and unforeseen delay August 20th 2010 (please see Partnering project W81XWH-08-1-0730, Task #2). The Data Safety Monitoring Board and all other requirements for subject ... |
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| Ketamine as a Rapid Treatment for Post-Traumatic Stress Disorder |
Oct 2011 |
5 pages |
| Authors:
Dennis Charney; MOUNT SINAI SCHOOL OF MEDICINE NEW YORK
|
| Post-traumatic stress disorder (PTSD) is a debilitating anxiety disorder characterized by intrusive re-experiencing of the traumatic events, avoidance of situations and stimuli that could serve as reminders of these events, and chronic hypervigilance. Patients with PTSD are often also depressed, and many have significant memory impairments. In the present study, we expect a single ketamine infusion to reduce core PTSD symptoms. In addition, in those patients with PTSD who are ... |
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| Cognitive and Perceptual Performance Effects of Controlled Exposure to Acute Hypoxic Stress |
12 Sep 2011 |
3 pages |
| Authors:
Jeffrey B Phillips; NAVAL MEDICAL RESEARCH UNIT DAYTON WRIGHT-PATTERSON AFB OH
|
| Since FY-2000, DoD has reported four hypoxia-related Class A mishaps costing four pilots' lives and over $300 million in aircraft. In addition, the F/A-18 community has filed 113 hypoxia-related HAZREPS since 2001. A 2010 survey conducted on tactical aviators indicated that 79% of hypoxic episodes go unreported, suggesting that the problem is far more prevalent than official statistics suggest (Deussing et al., 2011). Current emergency procedures for hypoxic events require ... |
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| Enhancing Emotion Regulation during Driving in OEF/OIF Veterans |
01 Sep 2011 |
7 pages |
| Authors:
Steven Woodward; PALO ALTO INSTITUTE FOR RESEARCH AND EDUCATION INC CA
|
| The proposed project aims to develop and test an intensive rehabilitative technology aimed at enhancing emotion regulation and reducing operator-related risk during civilian driving in OEF/OIF returnees burdened by severe driving-related distress and disability. This in-car technology will have two main components. The first is a system for measuring driving behavior (accelerator and steering wheel movements, lateral and longitudinal vehicle accelerations), visual attentional control, and autonomic arousal during actual driving. ... |
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| Chronic Stress and Performance |
Sep 2011 |
32 pages |
| Authors:
Melissa Boudreau; Erica M Johnson; James P Herman; CINCINNATI UNIV OH
|
| Stressors are a natural component of life for all mammals. The stress response is a physiological reaction to stressors that may be amenable to change by a variety of situations. Chronic stressors in the form of social stressors, physical stressors, the combination of both social and physical stressors, and the administration of the stress hormone corticosterone have a variety of effects on various measures of animal performance. In particular, chronic ... |
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| Review of Military Mountain Medicine Technology and Research Barriers |
Sep 2011 |
26 pages |
| Authors:
NATO RESEARCH AND TECHNOLOGY ORGANIZATION NEUILLY-SUR-SEINE (FRANCE)
|
| The subject matter of this review is hypobaric hypoxia, an environmental stress resulting from ascent to progressively higher terrestrial elevation or altitude above 1,200 meters (m) (3,937 feet (ft)). NATO RTO HFM-146 reviewed the empirical evidence of the adverse impact of high terrestrial elevations on health and physical and mental performances and current capabilities to mitigate these aversive impacts. The report identifies needed mountain medicine capabilities and technology and research ... |
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| Improving Health-care Delivery for Post-Traumatic Stress Disorder: An Interrelated Approach Leveraging Systems Engineering and Optimization |
Sep 2011 |
79 pages |
| Authors:
Scott A McKenzie; NAVAL POSTGRADUATE SCHOOL MONTEREY CA
|
| Post-Traumatic Stress Disorder (PTSD), major depression, anxiety disorders, and other post-deployment adjustment difficulties affect a significant number of veterans returning from Operation Iraq Freedom and Operation Enduring Freedom. To contend with this new influx of veterans suffering from the psychological aftermath of military combat, the VA has been proactive, including commissioning this study of their PTSD health-care delivery system. Its objective is to provide the best care, in the most ... |
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| Mortuary Affairs Soldiers: Early Intervention and Altering Barriers to Care for Traumatic Stress and PTSD |
Sep 2011 |
33 pages |
| Authors:
Carol S Fullerton; Quinn M Biggs; HENRY M JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE ROCKVILLE MD
|
| This project was designed to implement and assess the feasibility of a unique and newly-developed intervention (TEAM: Troop Education for Army Morale: Units and Individuals Working Together). TEAM is designed to meet the specific post deployment needs of Mortuary Affairs (MA) Soldiers through individual training, active engagement in problem solving and accessing care, enhanced buddy care and spouse support. Short and longer-term outcome in MA Soldiers are assessed. Specific aims ... |
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| Neurocognitive and Biomarker Evaluation of Combination mTBI from Blast Overpressure and Traumatic Stress |
Sep 2011 |
5 pages |
| Authors:
Stephen Ahlers; GENEVA FOUNDATION LAKEWOOD WA
|
| Mild traumatic brain injury (mTBI) and post-traumatic stress disorder (PTSD) are major medical issues for the warfighter. The current project is designed to evaluate the impact of mild traumatic brain injury (using blast over pressure) and traumatic stress (using a predator exposure procedure and conditioned fear procedure) in a rodent model. The studies evaluate these insults alone and in combination to specifically address the question of whether mTBI can exacerbate ... |
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| Neurocognitive and Biomarker Evaluation of Combination mTBI from Blast Overpressure and Traumatic Stress |
Sep 2011 |
19 pages |
| Authors:
Raymond Genovese; GENEVA FOUNDATION LAKEWOOD WA
|
| Mild traumatic brain injury (mTBI) and post-traumatic stress disorder (PTSD) are major medical issues for the warfighter. The current project is designed to evaluate the impact of mild traumatic brain injury (using blast over pressure) and traumatic stress (using a predator exposure procedure and conditioned fear procedure) in a rodent model. The studies evaluate these insults alone and in combination to specifically address the question of whether mTBI can exacerbate ... |
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| Metabolic Stress Induced by Arginine Deprivation Induces Autophagy Cell Death in Prostate Cancer |
Aug 2011 |
20 pages |
| Authors:
Richard Bold; CALIFORNIA UNIV DAVIS
|
| The primary purpose of this research grant is to provide the necessary preclinical data demonstrating that prostate cancer cells are auxotrophic for arginine and therefore targeting arginine metabolism is a novel therapeutic approach. The primary methodology involves cell culture with the characterization of the arginine requirements for prostate cancer cell growth and then determination of the effect of arginine depletion on cell growth and cell death. Furthermore, we have investigated ... |
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| Neuroinflammatory Pathobiology in Gulf War Illness: Characterization with an Animal Model |
Aug 2011 |
13 pages |
| Authors:
Stephen M Lasley; James P O'Callaghan; Diane B Miller; ILLINOIS UNIV AT CHICAGO
|
| Gulf War Illness (GWI) is a multi-symptom disorder with features characteristic of sickness behavior, including cognitive impairment, fatigue, depression, sleep disruption, and gastrointestinal and dermatological problems. Sickness behavior, a normal manifestation of an inflammatory response due to infection or injury, resolves when homeostasis is restored, but in GWI the symptoms persist, findings suggestive of a heightened or chronic neuroimmune/neuroinflammatory disorder. The expression of proinflammatory cytokines and chemokines are the basis ... |
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| Conditioned Fear Extinction and Generalization in Posttraumatic Stress Disorder |
Aug 2011 |
18 pages |
| Authors:
Seth D Norrholm; EMORY UNIV ATLANTA GA
|
| Post-traumatic stress disorder (PTSD) can affect an individual following exposure to a traumatic event. The exposure to trauma can evoke intense physical and emotional responses. Psychophysiological symptoms of PTSD can include an enhanced startle response; an effect that may result from an inability to inhibit fear. Conditioned fear can be measured using paradigms such as fear conditioning and fear extinction. Fear-potentiated startle is the process by which an individual s ... |
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| Anatomical and Physiological Changes Secondary to PTSD (Podcast) |
23 JUN 2011 |
1 pages |
| Authors:
Thomas DeGraba; Robert Koffman; Gerard Riedy; NATIONAL NAVAL MEDICAL CENTER BETHESDA MD NATIONAL INTREPID CENTER OF EXCELLENCE
|
| The National Intrepid Center of Excellence (NICoE) began caring for service members coping with traumatic brain injury (TBI) and psychological health in October 2010. Dedicated to delivering hope, healing, discovery and learning, the facility is both "high-tech" and "high-touch," focused on interdisciplinary, holistic and family-centered care. This month, DCoE is partnering with the NICoE to look at co-occurrences of post-traumatic stress disorder (PTSD) and TBI within patient populations,and ongoing research ... |
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| Defense Centers of Excellence: Limited Budget and Performance Information on the Center for Psychological Health and Traumatic Brain Injury |
JUN 2011 |
35 pages |
| Authors:
Denise M. Fantone; Carol M. Henn; Erinn L. Sauer; Michael Aksman; Alexandra Edwards; Robert Gebhart; Jyoti Gupta; Chelsa Gurkin; Felicia Lopez; Steven Putansu; GOVERNMENT ACCOUNTABILITY OFFICE WASHINGTON DC
|
| The National Defense Authorization Act for Fiscal Year 2008 (NDAA) directed DOD to establish centers of excellence for traumatic brain injury and post-traumatic stress disorder. Although the NDAA described responsibilities for the centers, it did not specify where the centers should be located within the DOD organization. Instead, it directed the Secretary of Defense to ensure that to the maximum extent practicable centers collaborate with governmental, private, and nonprofit entities. ... |
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| Endoplasmic Reticulum-Associated Degradation Factor ERLIN2: Oncogenic Roles and Molecular Targeting of Breast Cancer |
JUN 2011 |
9 pages |
| Authors:
Zeng-Quan Yang; WAYNE STATE UNIV DETROIT MI
|
| Amplification of the chromosome 8p11-12 region has been found in approximately 15% of human breast cancer and is associated with poor prognosis. Previous genomic analysis has led us to identify an endoplasmic reticulum (ER) lipid raft-associated 2 (ERLIN2) gene as one of candidate oncogenes within the 8p11-12 amplicon in human breast cancer. ERLIN2 is an ER membrane protein that was recently identified as a novel mediator of ER-associated degradation. In ... |
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| A Summary of Simulator Sickness Ratings for U.S. Army Aviation Engineering Simulators |
Jun 2011 |
50 pages |
| Authors:
Jamison S Hicks; David B Durbin; ARMY RESEARCH LAB ABERDEEN PROVING GROUND MD HUMAN RESEARCH AND ENGINEERING DIRECTORATE
|
| The U.S. Army Research Laboratory Human Research and Engineering Directorate (ARL HRED) uses U.S. Army Aviation engineering helicopter simulators to assess crewstation design for new or modified aircraft. This report summarizes pilot Simulator Sickness Questionnaire (SSQ) ratings for seven engineering simulators. The ratings were obtained from pilots during the assessments and used to identify if the simulators induced simulator sickness (SS) symptoms, if the symptoms caused significant discomfort which distracted ... |
|
| A Novel Anti-Beta2-Microglobulin Antibody Inhibition of Androgen Receptor Expression, Survival, and Progression in Prostate Cancer Cells |
MAY 2011 |
23 pages |
| Authors:
Wen-Chin Huang; CEDARS-SINAI MEDICAL CENTER LOS ANGELES CA
|
| Beta2-microglobulin (beta2M) is a signaling and growth-promoting factor stimulating prostate cancer cell proliferation and progression. Blockade of the beta2M signaling axis by anti-beta2M monoclonal antibody (beta2M mAb) resulted in the inhibition of androgen receptor (AR) and its target gene, prostate-specific antigen (PSA), and the induction of programmed death of prostate cancer cells in vitro and in vivo. We identified a new cis-acting element, sterol regulatory element-binding protein-1 (SREBP-1) binding site, ... |
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| Assessing the Comprehensive Soldier Fitness Program: Measuring Startle Response and Prepulse Inhibition |
APR 2011 |
27 pages |
| Authors:
Domeca Henderson; Adam Lary; Lolita M. Burrell; Michael D. Matthews; MILITARY ACADEMY WEST POINT NY DEPT OF BEHAVIORAL SCIENCES AND LEADERSHIP
|
| Historically, studies on Soldiers returning from combat focus on the potential for negative health outcomes such as posttraumatic stress disorder. However, current research is also assessing potential positive outcomes associated with combat such as resilience and posttraumatic growth. The Comprehensive Soldier Fitness Program is designed to promote psychological fitness by developing strengths in the emotional, spiritual, social and family domains. Though the program has produced some gains in building resilience ... |
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| The Use of Neuropeptide Y as a Measurement of the Effectiveness of Stress Inoculation |
APR 2011 |
27 pages |
| Authors:
Brian Clayton; Christopher Brown; Lolita Burrell; Michael Matthews; MILITARY ACADEMY WEST POINT NY DEPT OF BEHAVIORAL SCIENCES AND LEADERSHIP
|
| Post-traumatic stress disorder and other stress-related illnesses constitute a large number of casualties in the United States Army. To prevent the performance-degradation effects of stress, the concept of stress inoculation develops, which allows for the development of stress resilience through the gradual introduction of stressors. Comprehensive Soldier Fitness is one stress inoculation program developed by the Army. However, its effectiveness is unproven. One way to measure a person?s resilience to ... |
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| Biomarkers of Risk for Post-Traumatic Stress Disorder (PTSD) |
APR 2011 |
38 pages |
| Authors:
Audrey Tyrka; BUTLER HOSPITAL PROVIDENCE RI
|
| The objective of this project was to study genetic and neuroendocrine biomarkers of risk in a carefully assessed population of military personnel who recently returned from war zones. Baseline and 12-month follow-up assessment data were collected on behavioral and psychosocial measures. Major findings were that the COMT Val/Met polymorphism, interacted with combat exposure to predict diagnoses of PTSD; specifically individuals with the Met allele appeared more sensitive to higher levels ... |
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| Biomechanical and Physiological Validation of the Omni-Directional Treadmill Upgrade as a Mobility Platform for Immersive Environments |
Apr 2011 |
38 pages |
| Authors:
Angela C Boynton; Kathy L Kehring; Timothy L White; ARMY RESEARCH LAB ABERDEEN PROVING GROUND MD
|
| Technological advances in computer graphics combined with the development of large rearprojection surround displays have enabled the creation of virtual environments that visually immerse the user into a sense of real-world presence. Integration of these visual displays with a mobility interface that enables the user to move through the virtual environment provides instrumentation for more interactive applications. The mobility interface can be as simple and abstract as a mouse or ... |
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| Measures of Autonomic Nervous System |
Apr 2011 |
28 pages |
| Authors:
Patricia Brierley-Bowers; Scott Sexton; David Brown; Mark Bates; DEFENSE CENTERS OF EXCELLENCE FOR PSYCHOLOGICAL HEALTH AND TRAUMATIC BRAIN INJURY ARLINGTON VA
|
| Mind-body health practices aim to regulate activation of the sympathetic nervous system (SNS) to maintain homeostasis within the autonomic nervous system (ANS). The activation of the SNS is directly related to stress response, which, if persistent or prolonged, may lead to physiological and psychological damage. The ability to return to homeostasis after exposure to a stressor or to moderate SNS activation is a measure of resilience. In order to measure ... |
|
| Measures of Autonomic Nervous System Regulation |
Apr 2011 |
28 pages |
| Authors:
Patricia Brierley-Bowers; Scott Sexton; David Brown; Mark Bates; DEFENSE CENTERS OF EXCELLENCE FOR PSYCHOLOGICAL HEALTH AND TRAUMATIC BRAIN INJURY ARLINGTON VA
|
| Mind-body health practices aim to regulate activation of the sympathetic nervous system (SNS) to maintain homeostasis within the autonomic nervous system (ANS). The activation of the SNS is directly related to stress response, which, if persistent or prolonged, may lead to physiological and psychological damage. The ability to return to homeostasis after exposure to a stressor or to moderate SNS activation is a measure of resilience. In order to measure ... |
|
| Defining Total Force Fitness for the 21st Century |
21 MAR 2011 |
64 pages |
| Authors:
Joan A. Walter; SAMUELI INST FOR INFORMATION BIOLOGY ALEXANDRIA VA
|
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| Stress and Traumatic Brain Injury: A Behavioral, Proteomics, and Histological Study |
07 MAR 2011 |
15 pages |
| Authors:
Sook-Kyung C. Kwon; Erzsebet Koveski; Andrea B. Gyorgy; Daniel Wingo; Alaa Kamnaksh; John Walker; Joseph B. Long; Denes V. Agoston; UNIFORMED SERVICES UNIV OF THE HEALTH SCIENCES BETHESDA MD
|
| Psychological stress and traumatic brain injury (TBI) can both result in lasting neurobehavioral abnormalities. Post-traumatic stress disorder and blast induced TBI (bTBI) have become the most significant health issues in current military conflicts. Importantly, military bTBI virtually never occurs without stress. In this experiment, we assessed anxiety and spatial memory of rats at different time points after repeated exposure to stress alone or in combination with a single mild blast. ... |
|
| Novel Pharmacological Approaches for Treatment of Neurotoxicity Induced by Chronic Exposure to Depleted Uranium |
Mar 2011 |
15 pages |
| Authors:
Stephen D Lasley; ILLINOIS UNIV AT CHICAGO
|
| The chemical properties and high density of depleted uranium (DU) render the metal well suited for military purposes. The U. S. Army utilizes DU for tank armor and in munitions, deployed such weapons in the first Gulf War, and is currently deploying them in Afghanistan. However, knowledge of DU neurotoxicity and its treatment is lacking despite reports of exposed cohorts exhibiting neurocognitive dysfunction (1). Research in chronically exposed rats has ... |
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| Body Mass Bias in a Combat Fitness Test |
07 Feb 2011 |
46 pages |
| Authors:
Jr Vickers Ross R; John H Reynolds; Brian J McGuire; NAVAL HEALTH RESEARCH CENTER SAN DIEGO CA
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| Allometric theory predicts that, pound for pound, lighter individuals will perform better than heavier individuals on strength and endurance tests. This study evaluated body mass bias as a factor in the U.S. Marine Corps Combat Fitness Test (CFT), a test consisting of movement to contact (Movement), an ammunition can lift (Lift), and maneuver under fire (Maneuver). Allometric modeling indicated small to moderate biases, favoring lighter Marines for each CFT element. ... |
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| Emerging Generation of Post-Traumatic Stress Disorder Victims |
02 FEB 2011 |
30 pages |
| Authors:
Joe E. Arnold; ARMY WAR COLL CARLISLE BARRACKS PA
|
| The U.S. Army has been at war for more than nine years. Despite our successes on the battlefield, our forces remain engaged with enemies that pose unseen mental challenges. Today's leaders and Soldiers serve in operational tempos that challenge the moral fiber of our great Army. The stressors of repeated deployments are approaching a breaking point. These stressors are manifested as latent pre-deployment period as they begin the first phase ... |
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STRESS(PHYSIOLOGY)
