| Jet Fuel Exposure and Neurological Health in Military Personnel |
JUL 2007 |
13 pages |
| Authors:
Susan P. Proctor; HENRY M JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE ROCKVILLE MD
|
 | Jet propulsion fuel 8 (JP-8) has recently been recognized by the Department of Defense as the single largest chemical exposure for its personnel. The primary aim of the project is to conduct an epidemiological field study to examine the relationship between JP-8 fuel exposure and adverse neurological health in military personnel. The research objectives are as follows: (1) determination of the individual service member's level of exposure to JP-8 components ... |
|
| Injury Thresholds for Topical Cream-Coated Skin of Hairless Guinea Pigs (Cavia Procellus) in Near Infrared Region |
JUN 2006 |
29 pages |
| Authors:
David J. Stolarski; Justin J. Zohner; Michelle L. Imholte; Lucas J. Chavey; Ginger M. Pocock; Kelvin C. Buchanan; Nichole M. Jindra; Manuel A. Figueroa; Robert J. Thomas; Benjamin A. Rockwell; NORTHROP GRUMMAN CORP SAN ANTONIO TX INFORMATION TECHNOLOGY
|
| The reflectance and absorption of the skin plays a vital role in determining how much radiation will be absorbed by human tissue. Any substance covering the skin would change the way radiation is reflected and absorbed and thus the extent of thermal injury. Hairless guinea pigs (cavia porcellus) in vivo were used to evaluate how the minimum visible lesion threshold for single-pulse laser exposure is changed with a topical agent ... |
|
| Analyzing the Utilization of Interferon-Gamma Screening for Tuberculosis at Recruit Training Command, Great Lakes |
31 MAY 2006 |
42 pages |
| Authors:
David P. Mitchell; NAVAL HOSPITAL GREAT LAKES IL
|
| The tuberculin skin test for diagnosis of Mycobacterium tuberculosis has many limitations when applied to serial testing of recruits in a restrictive training environment. One year ago the FDA approved QuantiFERON-TB Gold (Trademark) as a blood test to screen for tuberculosis and latent tuberculosis. This product uses a combination of CFP-10 and ESAT-6 proteins to elicit in vitro response of white blood cells to detect prior exposure to m. tuberculosis. ... |
|
| A Medical Research and Evaluation Facility (MREF) and Studies Supporting the Medical Chemical Defense Program: Task Order 0008, Phase I and II: Canadian Reactive Skin Decontamination Lotion (RSDL) |
AUG 2004 |
18 pages |
| Authors:
Carl T. Olson; James E. Estep; Carol L. Sabourin; Tom Snider; Timothy Hayes; BATTELLE MEMORIAL INST COLUMBUS OH
|
| Battelle's Medical Research and Evaluation Facility (MREF) was tasked to determine the decontaminant effectiveness of Reactive Skin Decontaminant Lotion (RSDL) and to assist U.S. Army Medical Materiel Development Activity (USAMMDA) in requesting a marketing clearance from the U.S. Food and Drug Administration (FDA) as part of the Foreign Comparative Testing (FCT) program and the Joint Services Fixed Site Decontamination System (JSFXD) Program. The task was divided into two phases. Phase ... |
|
| Long-Term Health Effects of Repeated Exposure to Multiple Vaccines |
2004 |
13 pages |
| Authors:
Phillip R. Pittman; Kevin M. Coonan; Paul H. Gibbs; Helen M. Scott; Timothy L. Cannon; ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD
|
| The health of 155 former workers in a US military research program who had received multiple vaccines and 265 matched community controls was assessed. The study population was mostly male (83%) and elderly (median age, 69 years). Multiple immunized (MIP) subjects received vaccines and/or skin tests (median = 154) over a median of 17.3 years; interval from start of immunizations to survey completion was 15-55 years (mean = 43.1 years). ... |
|
| Human Dermal Fibroblasts (Adult): Instructions for Initiation of Cultures from Cryopreserved Cells and Subculture |
APR 2002 |
17 pages |
| Authors:
David W. Kahler; Carmen M. Arroyo; ARMY MEDICAL RESEARCH INST OF CHEMICAL DEFENSE ABERDEEN PROVING GROUND MD
|
| This technical report outlines procedures that have been developed to provide a cost effective way to produce large quantities of normal human skin fibroblast cells (NHSFs) for studying the mechanism(s) of action of chemical warfare agents (CWAs) and medical counter-measurements against CWAs. Various growth factors were added to media recommended by the supplier, American Type Culture Collection (ATCC), Manassas, Virginia, USA. Cell viability, cell differentiation and cell proliferation were evaluated ... |
|
| Tuberculosis Infection Among Young Adults Enlisting in the United States Navy |
2000 |
6 pages |
| Authors:
B. Smith; M. A. Ryan; G. C. Gray; J. M. Polonsky; D. H. Trump; NAVAL HEALTH RESEARCH CENTER SAN DIEGO CA
|
| Tuberculosis (TB) is a re-emerging infectious disease threat worldwide. To protect the health and readiness of US military personnel, policies exist to screen for and treat latent TB infection at the time of service entrance. Results of this screening programme have not been recently described. Multivariate regression techniques were used to evaluate demographic and medical data associated with TB infection among all young adults entering US Navy enlisted service between ... |
|
| A Medical Research and Evaluation Facility and Studies Supporting the Medical Chemical Defense Program. Task 92-29: Efficacy Assessment of Topical Skin Protectants against Sulfur Mustard Vapors in Hairless Guinea Pigs |
SEP 97 |
67 pages |
| Authors:
Carl T. Olson; T. H. Snider; H. W. Nitz; J. B. Johnson; BATTELLE MEMORIAL INST COLUMBUS OH
|
| The objective of this work was to determine the dose-response relationship between the duration of a topical exposure of sulfur mustard vapors to hairless guinea pigs (HGPs) and the incidence of microblisters observed histologically. The dose-response curve was compared to results of similar work performed at the U.S. Army Medical Research Institute of Chemical Defense (USAMRICD). The effects of ketamine hydrochloride anesthesia on HGP skin reflectance were also examined. The ... |
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| Acute Dermal Toxicity Evaluation of Product Solutions Resulting from the Chemical Neutralization of HD, GB, and VX via Monoethanolamine (MEA) |
JUL 97 |
|
| Authors:
Eugene J. Olajos; Kenneth P. Cameron; Ruth A. Way; James H. Manthei; Dale H. Heitkamp; EDGEWOOD RESEARCH DEVELOPMENT AND ENGINEERING CENTER ABERDEEN PROVING GROUNDMD
|
 | Acute dermal studies (lethality screen and skin irritation) were conducted on New Zealand White rabbits to ascertain the systemic toxicity and skin-injurant potential of monoethanolamine (MEA)-neutralized sulfur mustard (HD), sarin (GB), and VX. The lethality screen (limit test) consisted of a 24- hour occluded exposure to 1 ml/kg of 'test article.' Dermal irritation studies were based on a 4-hour occluded exposure to 0.5 ml of 'test article.' Chemical neutralization of ... |
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| Development of Reactive Topical Skin Protectants against Sulfur Mustard and Nerve Agents |
JUN 1997 |
|
| Authors:
Kenneth Klabunde; NANTEK INC MANHATTAN KS
|
| The purpose of the Phase I Research was to investigate the feasibility of using Nantek's unique reactive nanoparticle (RNP) adsorbents as the active ingredient in a skin cream system for the protection against exposure to sulfur mustard and nerve agents. The scope of the work included: (1) study of mimic reactions with a broad array of adsorbents; (2) new adsorbent formulation development; (3) adsorbent-cream compatibility studies; (4) prototype skin system ... |
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| Dermal Toxicity Evaluation of Neutralized Chemical Agent Identification Sets (CAIS) with an Overview of the Dermal Toxicity of Vesicant Agents and their Degradation Products |
OCT 96 |
182 pages |
| Authors:
Eugene J. Olajos; Kenneth P. Cameron; Ruth A. Way; James H. Manthei; Dale H. Heitkamp; EDGEWOOD RESEARCH DEVELOPMENT AND ENGINEERING CENTER ABERDEEN PROVING GROUNDMD
|
| Acute dermal toxicity (limit test) and skin irritation studies were conducted in New Zealand white rabbits to ascertain the systemic toxicity and skin-injury potential of chemically-neutralized Chemical Agent Identification Sets (CAIS). Studies also included the assessment of oxidant/solvent systems and solvent induced toxicity. The toxicity limit test consisted of a 24-hr occluded exposure to 1.0 ml/kg of 'test article.' Dermal irritation studies were based on a 4-hr occluded exposure to ... |
|
| Investigation of Laser Damage on Skin by 1540 nm Er-Glass Laser |
16 SEP 1995 |
21 pages |
| Authors:
Alexei V. Lukashev; Sergei E. Sverchkov; Valery P. Solovyev; Boris I. Denker; Victor V. Engovatov; AKADEMIYA NAUK SSSR MOSCOW
|
| The report objective is to define skin response to different radiant exposure of short (nanosecond) and long (millisecond) laser pulses and reaction to multipulse action using Er-glass laser radiation (1540 nm). |
|
| Medical Surveillance Monthly Report (MSMR). Volume 1, Number 3, June 1995 |
Jun-1995 |
17 pages |
| Authors:
Bruce H Jones; Sharon L Ludwig; Mark V Rubertone; John F Brundage; Vincent P Fonseca; ARMED FORCES HEALTH SURVEILLANCE CENTER SILVER SPRING MD
|
| As part of an effort to comply with OSHA mandated and CDC recommended measures (1) to protect Health Care Workers (HCW) from occupationally acquired tuberculosis (TB) infections, an aggressive PPD skin testing program was instituted at WRAMC. The guidelines recommend using the data gathered in such a screening program to analyze TB infection risk by occupational group and location in the hospital. Of note, 30 cases of culture proven Mycobacterium ... |
|
| Sensible Heat Loss After Systemic Anticholinergic Treatment |
1994 |
6 pages |
| Authors:
M. A. Kolka; L. A. Stephenson; R. R. Gonzalez; ARMY RESEARCH INST OF ENVIRONMENTAL MEDICINE NATICK MA
|
| Systemic atropine administration decreases eccrine sweat gland release via competitive inhibition at cholinergic receptors and augments skin blood flow by a yet unknown mechanism. Increased skin blood flow promotes auxiliary radiative and convective heat flux by 20-100% in both warm and cold environments. These studies showed that the systemic dose of atropine (2 mg, im) was sufficient to block cholinergic sweat gland activity and core and skin temperatures were higher ... |
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| Effects of a High-Energy Food Supplement on Cold-Induced Thermogenesis |
AUG 93 |
|
| Authors:
A. L. Vallerand; I. Jacobs; DEFENCE AND CIVIL INST OF ENVIRONMENTAL MEDICINE DOWNSVIEW (ONTARIO)
|
| In previous studies, we have not been able to confirm the theory that energy substrate mobilization is a limiting factor for cold-induced thermogenesis (M) in humans. One possible explanation for the conflicting results is that the dose of energy substrates may not have been optimal. The goal of this study was to determine whether the ingestion of a high-energy food supplement (710 kcal or 2,970 kJ; Ensure Pulse) in the ... |
|
| A Physiological Evaluation of the Soldier Integrated Protective Ensemble (SIPE) Clothing System |
FEB 93 |
91 pages |
| Authors:
Bruce S. Cadarette; Mark D. Quigley; James M. McKay; Margaret A. Kolka; Michael N. Sawka; ARMY RESEARCH INST OF ENVIRONMENTAL MEDICINE NATICK MA
|
| The Soldier Integrated Protective Ensemble (SIPE) program is the initial step in developing an integrated modular clothing and equipment system for combat ground troops. This system will increase lethality, mobility, survivability, command and control and overall protection of the troops. This environmental chamber study compared physiological responses of volunteers exercising in MOPP O, MOPP 1, and MOPP 4 with equivalent SIPE configurations, including SIPE 4 with and without ambient air ... |
|
| Serum Levels of Two Immunological Markers, the Soluble Low Affinity Receptor for IGE (SFCERII, SCD23) and their Correlation with Age, Gender and the Onset of Childhood Atopy |
93 |
101 pages |
| Authors:
Alice L. Miller; AIR FORCE INST OF TECH WRIGHT-PATTERSON AFB OH
|
| Identifying predictive indicators of atopy could allow for the early intervention and/or prevention of atopic associated diseases within individuals identified to be at high risk. Two immunological factors advanced as candidates for such a role are sCD23 and sCD25. Soluble CD23 and CD25 expression were therefore examined in the cord blood of over 300 healthy newborns enrolled in the Tucson Children's Respiratory study. Additionally these factors were measured in sera ... |
|
| Comparative Morphology of Sulfur Mustard Effects in the Hairless Guinea Pig and a Human Skin Equivalent |
1993 |
8 pages |
| Authors:
J. P. Petrali; S. B. Oglesby; T. A. Hamilton; K. R. Mills; ARMY MEDICAL RESEARCH INST OF CHEMICAL DEFENSE ABERDEEN PROVING GROUND MD
|
| A commercially available human skin equivalent (HSE) was used as an in vitro organotypic skin model to study temporal morphological effects of sulfur mustard gas (HD). Light and electron microscopic analyses of the HD-human skin equivalent model (HD-HSE) were compared to the HD-hairless guinea pig model (HD-HGP). HSE samples were exposed to 10 micro l HD vapor for 8 min and harvested at selected times up to 24 h. Skin ... |
|
| Indeterminate HIV-1 Western Blots: Etiology, Natural History and Psychological Reactions |
24 SEP 91 |
88 pages |
| Authors:
Connie Celum; Thomas Inui; UNIV OF WASHINGTON SEATTLE SCHOOL OF MEDICINE
|
| 236 persons (cases) with past reactive human immunodeficiency virus type-1 (HIV-1) EIAS and indeterminate HIV-1 Western Blots (IWBS) were followed prospectively. Of the 159 cases followed > 6 months, 6 seroconverted (3.8% seroconversation risk). All 6 seroconverters reported HIV risk behaviors, all had p24 bands prior to seroconversion, and 5 of the 6 seroconverted within one month. HIV-1 culture, polymerase chain reaction, serum p24 antigen, and the recombinant assays, CBre ... |
|
| Irritation, Sensitization, and Acute Oral Toxicity of N-Methyl-N'- Nitroguanidine |
SEP 91 |
|
| Authors:
E. R. Kinkead; R. E. Wolfe; S. A. Salins; MANTECH ENVIRONMENTAL TECHNOLOGY INC DAYTON OH
|
| N-methyl-N' nitroguanidine (MNG) is being considered for use in explosive formulations. MNG is a flammable solid when wet and is considered to be an explosive when dry. Therefore, the compound must be maintained in a moist state. The acute oral toxicity was determined in male and female F 344 rats administered as a single dose in corn oil. The maximum suspension of MNG that could be delivered, lg MNG/kg body ... |
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| A Heat Shock Operon in Coxiella burnetii Produces a Major Antigen Homologous to a Protein in Both Mycobacteria and Escherichia coli |
MAR 88 |
|
| Authors:
Michael H. Vodkin; Jim C. Williams; ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD
|
| Q fever is caused by a gram-variable and weakly acid-fast-staining obligate intracellular bacterial parasite of eucaryotic cells (16). This bacterium, Coxiella burnetti, is unique among the pathogenic rickettsiae because it replicates in the microbicidal milieu of the phagolysosome, where it carries out a developmental cycle which consists of sporogenic differentiation with both binary and unequal cell division. Humans can be infected after exposure to only one virulent phase I microorganism ... |
|
| Unsteady Solution of the Boundary Layer Equations with Application to Space Shuttle Tiles |
JUN 85 |
|
| Authors:
Karen J. Lange; AIR FORCE INST OF TECH WRIGHT-PATTERSON AFB OH SCHOOL OF ENGINEERING
|
| Wind tunnel tests were conducted on space shuttle orbiter insulating articles. The data, processed by a heat estimation computer program, revealed a large discrepancy in magnitude of the heat transfer coefficient over the space shuttle tile when compared to that yielded by flat plate theory and thin skin test results. A suggested cause of this discrepancy was the nonisothermal wall effect. An unsteady compressible to investigate these effects. The boundary ... |
|
| Mechanisms of Protective Immunogenicilty of Microbial Vaccines of Military Medical Significance |
15 MAY 84 |
|
| Authors:
Michael S. Ascher; Monique A. Berman; CALIFORNIA UNIV IRVINE DEPT OF MEDICINE
|
| Initial clinical studies of Phase I Q fever vaccine (IND 610) and skin test were performed under this contract. A total of 242 volunteers received skin tests and 22 received vaccine at two dose levels. Skin test reactions were classified according to the duration of persistence of erythema and skin test results were correlated with serologic and in vitro lymphocyte stimulation results. A role for lymphocyte testing in predicting skin ... |
|
| Dermal Hazard Evaluation of Diethyl Chloroethyl Amine Underwear Fabric Treatment |
24 AUG 1982 |
|
| Authors:
Richard A. Angerhofer; Michael J. Topper; ARMY ENVIRONMENTAL HYGIENE AGENCY ABERDEEN PROVING GROUND MD
|
| To provide guidance for further skin testing, diethyl chloroethyl amine -- treated cotton underwear fabric was applied in patch form to the intact and abraded skin of New Zealand White rabbits. Treated cotton fabrics OD III DS 0.144 and White DS 0.079 did not cause primary skin irritation in rabbits under controlled test conditions. It was recommended that cotton fabrics reacted with diethyl chloroethyl amine to a degree of substitution ... |
|
| Investigation of Immunoregulatory Alphaglobulin (IRA) in Shock and Trauma |
JUL 1982 |
|
| Authors:
J. A. Mannick; BRIGHAM AND WOMEN'S HOSPITAL BOSTON MA
|
| Burn patients with greater than 30% body surface area burn were skin tested for hypersensitivity responsiveness to 4 standard recall antigens and were sensitized to dinitrochlorobenzene (DNCB). The results of the skin tests were compared on each occasion with the ability of the patients's serum in 10% concentration to suppress normal human lymphocyte stimulation by phytohemagglutinin (PHA) in tissue culture. Seventy-eight serum samples were taken and the immunosuppressive activity related ... |
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| Some Immunobiological Changes in Recruit Personnel during the Early Phase of Recruit Training |
01 FEB 1982 |
|
| Authors:
Earl A. Edwards; R. H. Rahe; NAVAL HEALTH RESEARCH CENTER SAN DIEGO CA
|
| Lymphocyte transformation and response to skin test antigens in Navy recruits were studied during the first 15 days of training to determine if there were significant changes in immune competence which could account for the high prevalence of ARD. Decreased response to skin test antigens at 24 hours was noted during the first 5 days. This response was normal from Day 9-15. In contrast, lymphocyte transformation was normal during the ... |
|
| Dermal Sensitization Potential of Candidate Insect Repellents: LAIR formulation (CHF1) N-(n-octyl) glutarimide (CHR2) N-(n-hexyl) glutarimide (CHR3) (E) 1,2,3,4-tetrahydro-6-methyl-1-(2-methyl-1-oxo-2-butenyl)quinoline (CHR5) 1, 2,3,4-tetrahydro-6-methyl- |
FEB 1982 |
|
| Authors:
John T. Fruin; Martha A. Hanes; Kenneth Black; Virginia L. Gildengorin; LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA
|
| Arthropods represent a potential disease threat to U.S. Military Forces; consequently, a program to develop improved insect repellents was developed. The dermal sensitization potential of candidate insect repellents was determined using guinea pigs. Test substances CHF1, CHR2, and CHR3 were clearly non-sensitizing. CHR5 and CHR6 were irritating, possibly sensitizing, and should be retested. (Author) |
|
| Mammalian Toxicology Testing: Problem Definition Study, AMTR Protocol/ Pricing Report |
APR 1981 |
|
| Authors:
R. H. Reuter; J. P. Glennon; LIFE SYSTEMS INC CLEVELAND OH
|
| The mammalian toxicology testing needed to meet the Army's toxicology requirements are cited. Standardized protocols have been identified and pricing information summarized in this report. The pricing information used a standardized pricing procedure that included basic cost elements such as direct labor, overhead, other direct costs, general and administrative costs and profit. The approach allows a cost comparison between various performance alternatives. The prototypes were considered representative of those needed ... |
|
| Topical Hazard Evaluation Program of Candidate Insect Repellent AI3-36468, US Department of Agriculture Proprietary Compound. |
12 SEP 1979 |
|
| Authors:
Allen W. Singer; ARMY ENVIRONMENTAL HYGIENE AGENCY ABERDEEN PROVING GROUND MD
|
| A preliminary hazard evaluation of AI3-36468 was performed by means of laboratory animal studies using rats, rabbits and guinea pigs. The technical grade compound caused mild primary skin irritation, but no eye or photoirritation in rabbits. It did not sensitize guinea pigs or demonstrate an acute ingestion hazard. (Author) |
|
| Topical Hazard Evaluation Program of Candidate Insect Repellent AI3-36437, US Department of Agriculture Proprietary Compound. |
12 SEP 1979 |
|
| Authors:
Allen W. Singer; ARMY ENVIRONMENTAL HYGIENE AGENCY ABERDEEN PROVING GROUND MD
|
| A preliminary hazard evaluation of AI3-36437 was performed by means of laboratory studies using New Zealand White Rabbits. The technical grade compound stained the skin of rabbits. This stain persisted at 7 days, and thus is considered unsuitable for use on human skin. (Author) |
|
| Topical Hazard Evaluation Program of Candidate Insect Repellent AI3-37528a, US Department of Agriculture Proprietary Compound, September 1978 - June 1979. |
12 SEP 1979 |
|
| Authors:
Allen W. Singer; ARMY ENVIRONMENTAL HYGIENE AGENCY ABERDEEN PROVING GROUND MD
|
| A preliminary hazard evaluation of AI3-37528A was performed by means of laboratory animal studies using New Zealand White rabbits. When 0.1 ml of technical grade compound was applied to the conjunctival sac of three rabbits, generalized convulsions occurred within 1 minute. Testing was discontinued, and the animals observed for other toxic signs. Convulsions continued 10 to 15 minutes, with all rabbits ultimately recovering. (Author) |
|
| Topical Hazard Evaluation Program of Candidate Insect Repellent AI3-36424, US Department of Agriculture Proprietary Compound, May 1976 - June 1979. |
12 SEP 1979 |
|
| Authors:
Allen W. Singer; ARMY ENVIRONMENTAL HYGIENE AGENCY ABERDEEN PROVING GROUND MD
|
| A preliminary hazard evaluation of AI3-36424 was performed by means of laboratory animal studies using rats, rabbits and guinea pigs. The technical grade compound did not cause any primary or photoirritation in rabbits, or any eye irritation. It did not sensitize guinea pigs or prove to be an acute ingestion hazard. (Author) |
|
| Heat Intolerance as a Function of Percent of Body Surface Involved with Miliaria Rubra, |
10 SEP 1979 |
|
| Authors:
Kent B. Pandolf; Tommy B. Griffin; Ella H. Munro; Ralph F. Goldman; ARMY RESEARCH INST OF ENVIRONMENTAL MEDICINE NATICK MA
|
| Twenty-four heat acclimatized male volunteers were wrapped as previously described but to produce miliaria rubra (heat rash) in specific regions of the body. Three experimental rash groups were involved: (1) the torso (17% total skin surface rashed, n = 6), (2) torso and arms (38%, n = 8), or (3) legs (41%, n = 6), while four subjects served as controls. All subjects were re-exposed to walking in the heat ... |
|
| Acquired Immunity to Pathogenic Fungi in Gnotobiotic Animals. |
FEB 1979 |
|
| Authors:
Edward Balish; WISCONSIN UNIV HOSPITALS MADISON
|
| During primary T. mentagrophytes infection of Strain 2 guinea pigs, the colony forming units (CFU) of fungi in the lesion peaked between days 7 and 14, while the lesion severity peaked between days 11 and 16. Concomitant with the latter peak, a pronounced depression in the in vitro mitogenic activity of spleen (SPC) and lymph node cells (LNC) was observed. Only after resolution of the primary infection (day 21) did ... |
|
| Stimulus Control in Instrumental Autonomic Conditioning and Arousal. |
AUG 1978 |
|
| Authors:
H. D. Kimmel; F. Brennan; M. Budrionis; M. Raich; L. Schonfeld; UNIVERSITY OF SOUTH FLORIDA TAMPA DEPT OF PSYCHOLOGY
|
| Three groups of Cebus albifrons monkeys (n = 4 in each) received instrumental conditioning of the skin conductance response (SCR), with periods of Sidman avoidance, response-contingent punishment, and brief times out from these contingencies. One group had previously received this conditioning with visual discriminative stimuli and was now given the same contingencies without the stimuli. A second group served as yoked controls for the first group. The third group received ... |
|
| A Clinico-Pathological and Immunoparasitological Study on Toxocariasis in Egypt. |
31 MAY 1978 |
|
| Authors:
Hamed Mahmoud Khalil; AIN SHAMS UNIV CAIRO (EGYPT) FACULTY OF MEDICINE
|
| A survey for the detection of the incidence of T.canis and T.cati infection among stray dogs and cats has been performed in Cairo and Giza Governorates. Similarly Toxocariasis in man at Dakahleya Governorate, Siwa Oasis, Qena and Asswan Governorates were done together with the determination of the incidence of Toxocara infection in dogs in these areas. Moreover, Toxocara infection was studied in cases associated with clinical syndromes and also as ... |
|
| Studies on the Total Intake Simulant DMMPA, |
AUG 1977 |
|
| Authors:
W. Dorothy McNally; P. A. Adie; DEFENCE RESEARCH ESTABLISHMENT SUFFIELD RALSTON (ALBERTA)
|
| Dimethyl morpholinophosphoramidate (DMMPA) has been tested for suitability as a simulant for chemical agents in studying the effectiveness of chemical defence procedures. Results show that it is easily detected in urine after percutaneous, oral and intramuscular administration. The compound is shown to have very low toxicity when administered acutely in mice. Twenty-eight days of application to the skin of rats and rabbits produced no evidence of damage to skin. DMMPA ... |
|
| Modulation of Delayed-Type Hypersensitivity and Cellular Immunity to Microbial Vaccines: Effects of Cyclophosphamide on the Immune Response to Tularemia Vaccine, |
21 JUL 1977 |
|
| Authors:
M. S. Ascher; Darien Parker; J. L. Turk; ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FREDERICK MD
|
|
| Topical Hazard Evaluation Program of Candidate Insect Repellent AI3-70763 3(N-n-Butly-N-Acetyl) Aminopropionic Acid-Ethyl Ester December 1976 - April 1977. |
10 JUN 1977 |
|
| Authors:
Maurice H. Weeks ; Brenda J. DeSean; ARMY ENVIRONMENTAL HYGIENE AGENCY ABERDEEN PROVING GROUND MD
|
| A hazard evaluation of AI3-70763 was conducted using New Zealand White rabbits for skin and eye studies; Hartley guinea pigs for a skin sensitization study and Sprague-Dawley, Wistar derived rats for determination of acute oral toxicity. |
|
| Preparation of Fungal Antigens and Vaccines: Studies on 'Coccidioides immitis' and 'Histoplasma capsulatum', |
1977 |
|
| Authors:
H. B. Levine; G. M. Scalarone; S. D. Chaparas; CALIFORNIA UNIV OAKLAND NAVAL BIOSCIENCES LAB
|
|
| Topical Hazard Evaluation of Candidate Insect Repellent AI3-35716-aGb N-Hexylvaleramide. |
04 NOV 1976 |
|
| Authors:
K. Clark Swentzel; Donald L. Bumgardner; ARMY ENVIRONMENTAL HYGIENE AGENCY ABERDEEN PROVING GROUND MD
|
| A hazard evaluation of AI3-35716-aGb was conducted using New Zealand White rabbits for skin and eye studies, Hartley guinea pigs for a skin sensitization study and Sprague-Dawley, Wistar-derived rats for determination of oral toxicity. It was recommended that AI3-35716-aGb be approved for further testing as a candidate insect repellent. (Author) |
|
| A One-Day Preseasonal Treatment in Pollen Allergy: Proposed Testing and Injection Procedures. |
30 SEP 1976 |
|
| Authors:
Mary H. Loveless ; LOVELESS (MARY H) WESTPORT CONN
|
| The plan was to analyze data accumulated during the past two decades on 93 persons with pollen hay fever whose preseasonal therapy had been completed in a single session of several hours by means of repeated intracutaneous injections given at 10-minute intervals. The amounts of antigen had been highly individualized, the aim being to convey as much as could be tolerated in each injection. |
|
| Toxic Hazards Research Unit Annual Technical Report: 1976 |
SEP 1976 |
184 pages |
| Authors:
J. D. MacEwen; E. H. Vernot; CALIFORNIA UNIV IRVINE
|
| The research programs of the Toxic Hazards Research Unit (THRU) for the period of June 1975 through May 1976 are reviewed in this report. Chronic toxicity experiments were conducted using JP-4, RJ-4 (perhydromethylcyclopentadiene) and RJ-5 (reduced dimers of bicyclopentadiene) jet fuels. Studies were carried out on the oncogenicity of hydrazine, 1,1- dimethylhydrazine and coal tar aerosol. The hepatotoxicity of dimethylnitrosamine was investigated by the oral route and, in conjunction with ... |
|
| Prompt Confirmation of Rocky Mountain Spotted Fever: Identification of Rickettsiae in Skin Tissues, |
06 JUL 1976 |
|
| Authors:
T. E. Woodward; C. E. Pedersen Jr.; C. N. Oster; L. R. Bagley; J. Romberger; ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FREDERICK MD
|
|
| Toxicological Testing of Selected Hazardous Materials for Transportation Purposes. |
APR 1976 |
|
| Authors:
K. C. Back; A. A. Thomas; J. D. MacEwen; AEROSPACE MEDICAL RESEARCH LAB WRIGHT-PATTERSON AFB OHIO
|
| A number of organic chemicals were subjected to selected toxicological tests prescribed for classification purposes in the Department of Transportation Hazardous Materials regulations. Some of these materials were also examined for skin corrosivity. Aqueous solutions of several common inorganic acids and bases were tested to establish dividing line between corrosive and non-corrosive concentrations. Test results are reported. (Author) |
|
| STUDIES ON THE PATHOGENESIS AND IMMUNITY OF TULAREMIA |
08 JUL 1953 |
1 pages |
| Authors:
CORA M. DOWNS; KANSAS UNIV LAWRENCE
|
| The purified polysaccharide (I) from Bacterium tularense was only slightly immunogenic to 100 LD50 doses of B. tularense in white mice and appeared to enhance the virulence of a partially virulent strain. The relation of Ascoli antigen to I is not understood; both I and the Ascoli antigen sensitized red cells and acted as antigens in precipitin tests and skin tests. The Ascoli antigen, I, and the I-sensitized red cells ... |
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Reports by Keyword(s)
SKIN TESTS
