| A Stepwise, Iterative Procedure to Constrain Stress Drop, Regional Attenuation Models, and Site Effects |
30-Sep-2009 |
11 pages |
| Authors:
W S Phillips; Mark D Fisk; ALLIANT TECHSYSTEMS INC SAN DIEGO CA
|
 | Accurate corrections for distance, source size, and site effects are needed for reliable use of regional seismic phases for discrimination and magnitude estimation. Procedures that simultaneously invert for attenuation, geometrical spreading, site, and source parameters have been shown to include many trade-offs and instabilities that have led to significantly inaccurate corrections for distance and source terms. Under previous work, we developed and applied an approach to constrain source parameters, including ... |
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| Urban-Small Building Complex Environment: W07US Stability Analysis, Volume AS-3 (Urban Versus Rural Diurnal Stability Cycles) |
Sep-2009 |
44 pages |
| Authors:
Gail Vaucher; ARMY RESEARCH LAB WHITE SANDS MISSILE RANGE NM
|
| This report documents the urban diurnal stability cycle research, an outgrowth of the ongoing Urban Stability research begun with the WSMR 2003 Urban Study field project. The long term goal for this investigation is to develop an empirical Neutral Event Forecast Model for the urban environment. This quest stems from the success of a Neutral Event Forecast Model which was created for an operational high energy laser test facility located ... |
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| Replicating Physiological Patterns of Activity with Prosthetic Stimulation |
Jul-2009 |
30 pages |
| Authors:
Shelley Fried; BOSTON VA RESEARCH INST MA
|
| We want to develop more effective methods of neural stimulation in order to improve the clinical outcomes associated with retinal prosthetics. To accomplish this, we are investigating the mechanism(s) by which different types of retinal neurons respond to electric stimulation. Previous studies have shown that ganglion cells, the output cells of the retina, can be activated directly and exclusively with short duration stimulus pulses[1-4]. However, the site of spike initiation ... |
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| Environmental Contamination: Lessons Learned from the Cleanup of Formerly Used Defense and Military Munitions Sites |
Jun-2009 |
22 pages |
| Authors:
Diane Raynes; Alison O'Neill; Anu Mittal; Elizabeth Beardsley; Justin Mausel; Amanda Leisoo; GOVERNMENT ACCOUNTABILITY OFFICE WASHINGTON DC
|
| Under the Defense Environmental Restoration Program (DERP), the Department of Defense (DoD) has charged the Army Corps of Engineers (the Corps) with cleaning up 4,700 formerly used defense sites (FUDS) and active sites that were under its jurisdiction when they were initially contaminated. The 661-acre Spring Valley site in Washington, D.C. is one such site. Like many other FUDS, the U.S. Army used the Spring Valley site during World War ... |
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| Evaluative Testing of Sheep Ranching Site 5LA2316, 5LA2366, and 5LA2359 on the Pinon Canyon Maneuver Site, Las Animas County, Colorado |
Jun-2009 |
279 pages |
| Authors:
Pamela Cowen; Kimberly Henderson; Minette Church; Rollin Craft; Cheryl Wagner; COLORADO UNIV AT COLORADO SPRINGS DEPT OF ANTHROPOLOGY
|
| In 2001, University of Colorado, Colorado Springs tested three sites on the Department of the Army's Pinon Canyon Maneuver Site in order to assess damage by tracked vehicles that breached protective fences around the sites during Army training maneuvers. All three sites were related to sheep ranching in the area between c. 1890 and c. 1910. 5LA2316 is the foundations of a substantial residential sheep ranch, complete with foundations of ... |
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| A Computational Tool for Evaluating THz Imaging Performance in Brownout Conditions at Land Sites Throughout the World |
Mar-2009 |
65 pages |
| Authors:
Seth L Marek; AIR FORCE INST OF TECH WRIGHT-PATTERSON AFB OH GRADUATE SCHOOL OF ENGINEERING AND MANAGEMENT
|
| This study quantifies terahertz (THz) or sub-millimeter imaging performance during simulated rotary-wing brownout or whiteout environments based on geographic location and recent/current atmospheric weather conditions. The atmospheric conditions are defined through the Air Force Institute of Technology Center for Directed Energy (AFIT/CDE) Laser Environmental Effects Definition and Reference or LEEDR model. This model enables the creation of vertical profiles of temperature, pressure, water vapor content, optical turbulence, and atmospheric particulates ... |
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| Building the Wall: The Efficacy of a US-Mexico Border Fence |
12-Dec-2008 |
112 pages |
| Authors:
John T Sherwood; ARMY COMMAND AND GENERAL STAFF COLL FORT LEAVENWORTH KS
|
| The construction of a US-Mexico border fence has proved an increasingly divisive method for securing the southern US border since its initial construction as the San Diego Fence in 1990. Since the terrorist attacks of September 11, 2001 the construction of a US-Mexico border fence has morphed from a method to stem the tide of illegal immigration from Mexico into a legislated method to prevent the entrance of terrorists. All ... |
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| Epigenetic Regulation of Chermokine Expression in Prostate Cancer |
Dec-2008 |
17 pages |
| Authors:
Michael R Shurin; PITTSBURGH UNIV PA
|
| Specific active immunotherapy is based on the principle that malignant cells contain immunogenic sites against which an antitumor immune response can be induced. Dendritic cells (DC) that acquire antigens from tumor cells are able to induce and regulate specific antitumor immunity. However, it is still unclear why the circulating DC do not induce efficient antitumor immunity in cancer patients. While successful immunotherapy requires a functional immune system, a defect in ... |
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| Soil Microbial Activity Benchmarks (Provisional) for Ecological Risk Assessments at Explosives-Contaminated Sites: Promoting Range Sustainability |
Dec-2008 |
8 pages |
| Authors:
R G Kuperman; R T Checkai; C T Phillips; M Simini; S Dodard; J Hawari; S Rocheleau; M Joly; G I Sunahara; EDGEWOOD CHEMICAL BIOLOGICAL CENTER ABERDEEN PROVING GROUND MD
|
| The Army Strategy for the Environment applies an ecosystem approach to managing natural resources on Army installations. It incorporates the principles of sustainability across the Army into all functional areas. We conducted investigations to develop critical data required for successful management of Army installations in a sustainable manner and for the knowledge-based decision making. Assessment and protection of the terrestrial environment at Army testing and training ranges is being advanced ... |
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| Nanovectors for Targeting and Delivery of Therapeutics to HER-2 NEU Positive Breast Cancer Cells |
Oct-2008 |
25 pages |
| Authors:
Rita E Serda; TEXAS UNIV HEALTH SCIENCE CENTER AT HOUSTON
|
| Nanofabricated devices designed to carry drug and contrast agents to breast cancer cells are surface modified with targeting moieties that recognize unique or abundantly expressed molecules on the surface of tumor cells. However, major obstacles such as enzymatic degradation, uptake by professional phagocytes and the reticular endothelial system, and the vascular endothelium could hinder the ability of nanoparticles to reach the tumor site. To overcome these biological barriers, we have ... |
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| Standardized UXO Technology Demonstration Site Open Field Scoring Record Number 910 (Sky Research, Inc.) |
01-Sep-2008 |
56 pages |
| Authors:
Rick Fling; Christina McClung; William Burch; Patrick McDonnell; J S McClung; Leonardo Lombardo; ABERDEEN TEST CENTER MD
|
| This scoring record documents the efforts of Sky Research, Inc. to detect and discriminate inert unexploded ordnance (UXO) utilizing the YPG Standardized UXO Technology Demonstration Site Open Field. This Scoring Record was coordinated by J. Stephen McClung and the Standardized UXO Technology Demonstration Site Scoring Committee. Organizations on the committee include the U.S. Army Corps of Engineers, the Environmental Security Technology Certification Program, the Strategic Environmental Research and Development Program, ... |
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| Standardized UXO Technology Demonstration Site Moguls Scoring Record Number 912 (Sky Research, Inc.) |
01-Sep-2008 |
63 pages |
| Authors:
Rick Fling; Christina McClung; William Burch; Patrick McDonnell; J S McClung; Leonardo Lombardo; ABERDEEN TEST CENTER MD
|
| This scoring record documents the efforts of Sky Research, Inc. to detect and discriminate inert unexploded ordnance (UXO) utilizing the YPG Standardized UXO Technology Demonstration Site Moguls. This Scoring Record was coordinated by J. Stephen McClung and the Standardized UXO Technology Demonstration Site Scoring Committee. Organizations on the committee include the U.S. Army Corps of Engineers, the Environmental Security Technology Certification Program, the Strategic Environmental Research and Development Program, the ... |
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| Standardized UXO Technology Demonstration Site Blind Grid Scoring Record Number 909 (Sky Research, Inc.) |
01-Sep-2008 |
53 pages |
| Authors:
Rick Fling; Christina McClung; William Burch; Patrick McDonnell; J S McClung; Leonardo Lombardo; ABERDEEN TEST CENTER MD
|
| This scoring record documents the efforts of Sky Research, Inc. to detect and discriminate inert unexploded ordnance (UXO) utilizing the YPG Standardized UXO Technology Demonstration Site Blind Grid. This Scoring Record was coordinated by J. Stephen McClung and the Standardized UXO Technology Demonstration Site Scoring Committee. Organizations on the committee include the U.S. Army Corps of Engineers, the Environmental Security Technology Certification Program, the Strategic Environmental Research and Development Program, ... |
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| Standardized UXO Technology Demonstration Site Desert Extreme Scoring Record Number 911 (Sky Research, Inc.) |
01-Sep-2008 |
56 pages |
| Authors:
Rick Fling; Christina McClung; William Burch; Patrick McDonnell; J S McClung; Leonardo Lombardo; ABERDEEN TEST CENTER MD
|
| This scoring record documents the efforts of Sky Research, Inc. to detect and discriminate inert unexploded ordnance (UXO) utilizing the YPG Standardized UXO Technology Demonstration Site Desert Extreme. This Scoring Record was coordinated by J. Stephen McClung and the Standardized UXO Technology Demonstration Site Scoring Committee. Organizations on the committee include the U.S. Army Corps of Engineers, the Environmental Security Technology Certification Program, the Strategic Environmental Research and Development Program, ... |
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| Low Impact Technologies to Reduce Pollution from Storm Water Runoff SI-200405 |
Sep-2008 |
155 pages |
| Authors:
Gary D Anguiano; Mark Foreman; NAVAL FACILITIES ENGINEERING SERVICE CENTER PORT HUENEME CA
|
| This project was to validate the performance of a dual media filtration system that removes metals, organic compounds, and sediment found in storm water runoff from DoD industrial sites. Full-scale demonstrations were conducted at the Navy Regional Recycling Center (NRRC) in San Diego, California and the Anniston Army Depot (ANAD) in Anniston, Alabama. The specific performance goal at NRRC was to meet the NPDES storm water permit by passing acute ... |
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| Cost and Performance Report Low Impact Technologies to Reduce Pollution from Storm Water Runoff SI-200405 |
Sep-2008 |
63 pages |
| Authors:
Gary D Anguiano; Mark Foreman; NAVAL FACILITIES ENGINEERING SERVICE CENTER PORT HUENEME CA
|
| This project was to validate the performance of a dual media filtration system that removes metals, organic compounds, and sediment found in storm water runoff from DoD industrial sites. Full-scale demonstrations were conducted at the Navy Regional Recycling Center (NRRC) in San Diego, CA and the Anniston Army Dept (ANAD) in Anniston, Alabama. The specific performance goal at NRRC was to meet the NPDES storm water permit by passing acute ... |
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| Demonstration of Helicopter Multi-Towed Array Detection System (MTADS) Magnetometry Technology at Pueblo Precision Bombing Range #2, Colorado |
28-Aug-2008 |
59 pages |
| Authors:
David Wright; Jack Foley; SKY RESEARCH ASHLAND OR
|
| The Pueblo Precision Bombing Range is located in Otero County, Colorado. This site is classified by the United States Government as a Formerly Used Defense Site (FUDS) and was a World War II-era military training facility. This demonstration utilized Helicopter Multi-Sensor Towed Array Detection System (MTADS) Magnetometry (HeliMag) technology, a wide area assessment technology. A data collection survey was conducted in September of 2005 and resulted in the survey of ... |
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| Standardized UXO Technology Demonstration Site Moguls Scoring No. 903 (Sky Research, Inc.) |
Aug-2008 |
67 pages |
| Authors:
Rick Fling; Christina McClung; William Burch; J S McClung; Leonardo Lombardo; Patrick McDonell; ABERDEEN TEST CENTER MD
|
| This scoring record documents the efforts of Sky Research, Inc. to detect and discriminate inert unexploded ordnance (UXO) utilizing the APG Standardized UXO Technology Demonstration Site Moguls. This Scoring Record was coordinated by J. Stephen McClung and the Standardized UXO Technology Demonstration Site Scoring Committee. Organizations on the committee include the U.S. Army Corps of Engineers, the Environmental Security Technology Certification Program, the Strategic Environmental Research and Development Program, the ... |
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| Jet Fuel Exposure and Neurological Health in Military Personnel |
Jul-2008 |
14 pages |
| Authors:
Susan P Proctor; JACKSON (HENRY M) FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE ROCKVILLE MD
|
| Jet propulsion fuel 8 (JP-8) has recently been recognized by the Department of Defense as the single largest chemical exposure for its personnel. The primary aim of the project is to conduct an epidemiological field study to examine the relationship between JP-8 fuel exposure and adverse neurological health in military personnel. The research objectives include 1) determination of the individual service member's level of exposure to JP-8 components while carrying ... |
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| NMMC Picture Archiving and Communication Systems (PACS) |
Jul-2008 |
27 pages |
| Authors:
Robert C Becker; NORTH MISSISSIPPI MEDICAL CENTER TUPELO MS
|
| This final report summarizes project activity from October 1, 2004 through June 30, 2008. All deliverables for this project were met: PACS equipment became fully operational at the NMMC-Tupleo campus, all five community hospitals (Eupora, Pontotoc, West Point, Iuka and Hamilton sites), and at 15 primary care clinics in rural Mississippi; Radiology staff at all sites were thoroughly training; Data collection and analysis continued with results reported; Network vulnerability assessment ... |
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| Preparing for Beslan: Anti-Terrorism Recommendations for an American School |
13 JUN 2008 |
121 pages |
| Authors:
Gregory D. Mittman; ARMY COMMAND AND GENERAL STAFF COLL FORT LEAVENWORTH KS
|
| The 2004 terrorist attack on a Beslan, Russia middle school left more than a hundred innocent schoolchildren dead and many more injured. In this tragedy's wake, numerous security experts offered American school officials recommendations on how to protect children in the United States. This study asks, "What anti-terrorism measures would be feasible, suitable, and acceptable in protecting an American school from an attack similar to the one that occurred in ... |
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| Mechanistic Basis of Calmodulin Mediated Estrogen Receptor Alpha Activation and Antiestrogen Resistance |
01-Jun-2008 |
38 pages |
| Authors:
Jeffrey L Urbauer; GEORGIA UNIV ATHENS
|
| Estrogen receptor alpha (ERa) is the principle chemotherapeutic target for estrogen dependent breast cancers. Calmodulin (CaM) is an obligatory ERa activator. Moreover, antiestrogens (tamoxifen) bind tightly to CaM, and some therapeutic benefits of antiestrogens for breast cancers are hypothesized to derive from this interaction. The purpose and scope of the research is to define the structural requisites of ERa activation by CaM and the relationship between tamoxifen binding to CaM, ... |
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| Development of a Design Tool for Planning Aqueous Amendment Injection Systems |
Jun-2008 |
77 pages |
| Authors:
Robert C Borden; Thomas Simpkin; M T Lieberman; Matthew Clayton; Aaron M Weispfenning; ENVIRONMENTAL SECURITY TECHNOLOGY CERTIFICATION PROGRAM OFFICE (DOD) ARLINGTON VA
|
| This design tool is intended to assist with the design of injection systems for distributing emulsified edible oils to stimulate in situ anaerobic bioremediation (AB) of groundwater contaminants. The design tool is intended to assist users in selecting an appropriate injection well spacing and amount of emulsified oil and water to inject. Prior to beginning use of the design tool, users should have already conducted a preliminary screening to determine ... |
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| Systemic and Gene Modified Mesenchymal Stem Cell Therapy for Metastatic Prostate Cancer |
01-May-2008 |
7 pages |
| Authors:
Selvarangan Ponnazhagan; ALABAMA UNIV IN BIRMINGHAM
|
| Bone is the frequent metastatic site for human prostate cancer resulting in significant morbidity and mortality in patients with advanced disease. The type of bone defect encountered in prostate cancer bone metastasis is osteoblast lesions resulting in excess bone. However, initiation of osteoclastogenesis is first aided by osteolysis, mediated by osteoclasts. The areas provided as source for osteoblast accumulation later leads to thickening of the bone. In this proposal, we ... |
|
| Characterize RAP80, a Potential Tumor Suppressor Gene |
01-Apr-2008 |
18 pages |
| Authors:
Xiaochun Yu; MICHIGAN UNIV ANN ARBOR
|
| To examine the molecular mechanism by which BRCA1 participates in breast tumor suppression we have identified that RAP8O is a BRCA1-associated protein by protein affinity purification. Here we show the evidence that RAP8O controls BRCA1's relocation to DNA damage sites and regulates BRCA1-dependent DNA damage checkpoint function. In addition we have identified a truncation mutation of RAP8O in an ovarian cancer cell line. Thus our results indicate that RAP8O is ... |
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| Shallow Water UXO Technology Demonstration Site Scoring Record No. 5 (NAEVA/XTECH, EM61 MKII) |
APR 2008 |
51 pages |
| Authors:
Gary Rowe; ABERDEEN TEST CENTER MD
|
| This report documents the efforts of NAEVA/XTECH to detect and discriminate inert unexploded ordnance (UXO) using an EM61 MKII. Testing was conducted at ATC, Standardized Shallow Water UXO Technology Demonstration Site. A description of the tested system and an estimate of survey costs along with the analysis of the system performance are provided. |
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| Ambient Noise Measurements in Mississippi Sound |
21 MAR 2008 |
23 pages |
| Authors:
Joal J. Newcomb; Steve Stanic; Alexandra Cranford; Delphine Vanderpool; Mobashir A. Solangi; NAVAL RESEARCH LAB STENNIS SPACE CENTER MS
|
| During the spring, summer, and fall of 2004, underwater ambient noise measurements were conducted in the Mississippi Sound. The Naval Research Laboratory, Stennis Space Center (NRL--Stennis) and the Institute for Marine Mammal Studies (IMMS) collaborated in acquiring acoustic ambient noise data at eight (8) sites in the Mississippi Sound. The sites were chosen to represent sites of expected high anthropomorphic noise sources and a control site with few or no ... |
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| Blast Pendulum Testing of Milliken Tegris Panels |
JAN 2008 |
|
| Authors:
Donald J. Grosch; Erick J. Sagebiel; Hal Eleazer; SOUTHWEST RESEARCH INST SAN ANTONIO TX
|
 | Milliken contracted Southwest Research Institute (SwRI) to conduct blast pendulum tests on various panels. The blast pendulum allows one to investigate a material's capability of mitigating sample deformation and bulk structural loading that result from close-in blast loading. The methodology is based upon placing a sample in a semi-rigid frame. The frame is supported by large supports that are free to rotate about a fixed position. Based upon the angular ... |
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| Use of a Recombinant Fluorescent Substrate with Cleavage Sites for All Botulinum Neurotoxins in High-Throughput Screening of Natural Product Extracts for Inhibitors of Serotypes A, B, and E7 |
14 DEC 2007 |
8 pages |
| Authors:
Harry B. Hines; Alexander D. Kim; Robert G. Stafford; Shirin S. Badie; Ernst E. Brueggemann; David J. Newman; James J. Schmidt; ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD
|
| The seven serotypes of botulinum neurotoxin (BoNTs) are zinc metalloproteases that cleave and inactivate proteins critical for neurotransmission. Synaptosomal protein of 25 kDA (SNAP-25) is cleaved by BoNTs A, C, and E, while vesicle-associated membrane protein (VAMP) is the substrate for BoNTs B, D. F. and G. BoNTs are not only medically useful drugs, but are also potential bioterrorist and biowarfare threat agents. Because BoNT protease activity is required for ... |
|
| A Summary of Eelgrass (Zostera marina) Reproductive Biology with an Emphasis on Seed Biology and Ecology from the Chesapeake Bay Region |
DEC 2007 |
12 pages |
| Authors:
Robert J. Orth; Scott R. Marion; Kenneth A. Moore; ENGINEER RESEARCH AND DEVELOPMENT CENTER VICKSBURG MS COASTAL AND HYDRAULICS LAB
|
| Interest in seagrass restoration is increasing worldwide as the value of seagrass ecosystems is recognized by scientists, managers and regulators (Orth et al. 2000, 2006b, 2006c). Seagrass transplanting projects have traditionally relied on adult plants (Fonseca et al. 1998) using a variety of manual and mechanical techniques (Fonseca et al. 1998, Fishman et al. 2004, Treat and Lewis 2006). However, most techniques using adult plants are laborintensive and time-consuming, requiring ... |
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| Wide Area UXO Contamination Evaluation by Transect Magnetometer Surveys |
Nov-2007 |
46 pages |
| Authors:
Nagi Khadr; Glenn Harbaugh; Daniel Steinhurst; NOVA RESEARCH INC SOLVANG CA
|
| We have demonstrated a suite of data collection and analysis methodologies to support the rapid delineation of UXO contamination within a suspect site. Transect plans were developed by Pacific Northwest National Laboratory (PNNL) and Sandia National Laboratories (SNL) in cooperation with the ESTCP Program Office. The transect plans were based on available archive information and designed to allow the efficient sampling of the demonstration sites for areas of interest (AOI) ... |
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| Open Architecture, Inventory Pooling and Spare Maintenance Assets |
18-Oct-2007 |
52 pages |
| Authors:
Geraldo Ferrer; NAVAL POSTGRADUATE SCHOOL MONTEREY CA GRADUATE SCHOOL OF BUSINESS AND PUBLIC POLICY
|
| The adoption of open architecture affects several economic components in the life of an asset including developmental costs maintenance costs and inventory management costs. This article focuses on the benefits provided by pooling together the inventory necessary to meet the demand of many users into a small number of storage sites with reduced product variety obtained with the adoption of Open Architecture (QA). The example showcased in this analysis distribution ... |
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| U.S. Embassy in Iraq |
10 OCT 2007 |
|
| Authors:
Susan B. Epstein; LIBRARY OF CONGRESS WASHINGTON DC CONGRESSIONAL RESEARCH SERVICE
|
| Concerns about the U.S. Embassy in Iraq have surfaced regarding the potential rising cost, delay in opening, quality of construction, and reported assertions of trafficking-like labor practices by First Kuwaiti General Trade and Contracting Company, the primary builder of the U.S. Embassy in Baghdad. On October 4, 2007, the Chairman of the House Foreign Affairs Committee, Representative Tom Lantos, sent questions to Deputy Secretary of State, John Negroponte, regarding concerns ... |
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| Nitric Oxide Generating Polymeric Coatings for Subcutaneous Glucose Sensors |
OCT 2007 |
11 pages |
| Authors:
Mark E. Meyerhoff; MICHIGAN UNIV ANN ARBOR
|
| Heretofore efforts to develop implantable sensors for real-time clinical monitoring of glucose subcutaneously (SQ) in diabetic patients have been hindered by the unreliable analytical results owing largely to biocompatibility problems induced by sensor implantation (e.g. inflammatory/foreign body response). The goal of this research program is to explore and optimize the chemistries required to fabricate implantable amperometric glucose sensors with outer polymeric coatings that slowly generate low levels of nitric oxide ... |
|
| Mechanisms Down-Regulating Sprouty1, a Growth Inhibitor in Prostate Cancer |
OCT 2007 |
63 pages |
| Authors:
Bernard Kwabi-Addo; HOWARD UNIV WASHINGTON DC
|
| The Sprouty gene family negatively regulates growth factor-induced receptor tyrosine kinase signaling with a potential tumor suppressor function in cancer. I have demonstrated that Sprouty1 is down-regulated in human prostate cancer. The purpose of the present study is to elucidate the relative contribution of transcription regulation and epigenetic DNA methylation changes in regulating Sprouty1 expression in human prostate cancer. Using transient transfection analysis in prostate cancer cell lines; I have ... |
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| SERDP and ESTCP Workshop on Technology Needs for the Characterization, Management, and Remediation of Military Munitions in Underwater Environments |
OCT 2007 |
46 pages |
| Authors:
DEPUTY DIRECTOR OF DEFENSE RESEARCH AND ENGINEERING ARLINGTON VA STRATEGIC ENVIRONMENTAL RESEARCH AND DEVELOPMENT PROGRAM
|
| This report summarizes the results of a workshop sponsored by the Department of Defense's (DoD) Strategic Environmental Research and Development Program (SERDP) and Environmental Security Technology Certification Program (ESTCP) that sought to determine the research, development, test, and evaluation (RDT&E) needs to survey sites containing underwater munitions. |
|
| Extending DoD Modeling and Simulation with Web 2.0, Ajax and X3D |
SEP 2007 |
227 pages |
| Authors:
Michael Farias; NAVAL POSTGRADUATE SCHOOL MONTEREY CA
|
| DoD has much to gain from open source Web 2.0 and Ajax Applications. The Java language has come a long way in providing real world case studies and scalable solutions for the enterprise that are currently in production on sites such as eBay.com (http://www.ebay.com) and MLB.com (http://www.mlb.com). The most popular Ajax application in production is Google Maps (http://maps.google.com), which serves as a good example of the power of the technology. ... |
|
| Inhibitors for Androgen Receptor Activation Surfaces |
SEP 2007 |
37 pages |
| Authors:
Robert J. Fletterick; SAN FRANCISCO UNIV CA
|
| Studies from this grant led to discovery of a new interaction site on the androgen receptor for binding proteins that regulate the function of the receptor. The protein binders have not been identified, but we showed that the site has the characteristics of functioning in repression. We used X-ray crystallography to discover the binding mode of four compounds that bind to this site. Their binding is accompanied by weakening the ... |
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| Interchromosomal Associations that Alter Nf1 Gene Expression can Modify Clinical Manifestations of Neurofibromatosis 1 |
SEP 2007 |
9 pages |
| Authors:
Andrew R. Hoffman; PALO ALTO INSTITUTE FOR RESEARCH AND EDUCATION INC CA
|
| We have described a new form of epistasis in which direct, long range, physical interactions between genes, or gene-gene interactions mediated by specialized DNA binding proteins such as CTCF, lead to modification of phenotypic read-out. Using the associated chromatin trap (ACT) and chromosome conformation capture (3C) assays which are designed to assess physical propinquity, we investigated long range interactions of the human NF1 gene that are mediated by CTCF in ... |
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| Identification of the Her-2 Functional Site: Blockage of Receptor Heterodimerization |
SEP 2007 |
15 pages |
| Authors:
Ruth Lupu; EVANSTON NORTHWESTERN HEALTHCARE RESEARCH INST IL
|
| Targeting HER2 is not as straightforward as it was originally predicted since many breast tumors express multiple HER receptors and co-express one or more HER ligands. This cross-talk network negatively impacts the response to the currently used HER2-targeted agents, highlighting the urgent need for a novel anti-HER2 molecule(s) presenting a combination strategy. Activation of the HER2 receptor is attained by several means: 1) receptor overexpression leads to homodimerization; 2) EGF ... |
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| Environmental Assessment for Construction of Storm Water Detection System at Storm Water Outfall #3, Malmstrom Air Force Base, Montana |
Aug-2007 |
89 pages |
| Authors:
James Denier; Rachel Wieland; Eric Farrington; Jeanne DeFauw; AIR FORCE CENTER FOR ENVIRONMENTAL EXCELLENCE BROOKS AFB TX
|
| The United States Air Force (USAF) has prepared this EA to assess the environmental and social impacts resulting from the proposed action to construct a storm water detention pond at storm water Outfall #3 planned for late Fiscal Year (FY) 2007 at Malmstrom AFB. This project proposes to construct a storm water detention pond at Malmstrom AFB storm water Outfall #3 to address flooding and erosion issues historically experienced at ... |
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| A Programmatic Approach to Determine Eligibility of Prehistoric Sites in the San Diego Subregion, Southern Coast Archeological Region, California, for the National Register of Historic Places |
AUG 2007 |
136 pages |
| Authors:
Seetha N. Reddy; Tad Britt; ENGINEER RESEARCH AND DEVELOPMENT CENTER CHAMPAIGN IL CONSTRUCTION ENGINEERING RESEARCH LAB
|
| This report presents the thematic landscape approach that will be taken to prepare the regional prehistoric context for the San Diego Subregion of the Southern Coast Archeological Region (SDSSCAR). The goal of this project was to research and develop a regional, archeologically based, historic context that will facilitate a programmatic approach to determining National Register of Historic Places (NRHP) eligibility for archeological sites at a subset of Navy Region Southwest ... |
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| Template for Conceptual Model Construction: Model Review and Corps Applications |
AUG 2007 |
22 pages |
| Authors:
Jim E. Henderson; L. J. O'Neil; ENGINEER RESEARCH AND DEVELOPMENT CENTER VICKSBURG MS
|
| This technical note reports on a review of conceptual model construction and use, and identifies how conceptual model use can be facilitated to better serve the Corps of Engineers (CE). Previously, Henderson and O'Neil (2004) described a six-step process for conceptual model development and discussed uses and applications of conceptual models in CE Planning and Operations activities. Observations that many Corps conceptual model applications had similar objectives and involved similar ... |
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| A Wetland Restoration Spatial Decision Support System for the Mississippi Gulf Coast |
AUG 2007 |
41 pages |
| Authors:
Jeff P. Lin; Barbara A. Kleiss; ENGINEER RESEARCH AND DEVELOPMENT CENTER VICKSBURG MS ENVIRONMENTAL LAB
|
| The Engineer Research and Development Center, Environmental Laboratory, has created a Wetlands Restoration Spatial Decision Support System (SDSS) based on Geographic Information System (GIS) tools. SDSS will be used to identify and prioritize potential wetland restoration areas along the Mississippi Gulf Coast as part of the non-structural solutions planned for that area following Hurricane Katrina. Advantages of the SDSS approach include relatively rapid identification and assessment of a large number ... |
|
| Evolution of Enzymes Required for Biodegradation of Pentachlorophenol in Sphingobium Chlorophenolicum |
15 JUN 2007 |
11 pages |
| Authors:
Shelley D. Copley; COLORADO UNIV AT BOULDER OFFICE OF CONTRACTS AND GRANTS
|
| Pentachlorophenol (PCP) is a highly toxic pesticide first introduced into the environment in 1936. PCP can be mineralized by Sphingobium chlorophenolicum. However, biodegradation is slow and the bacterium cannot tolerate high levels of PCP. Flux through the pathway is limited by the first enzyme, PCP hydroxylase, which converts PCP to tetrachlorobenzoquinone (TCBQ) very slowly. Furthermore, it catalyzes a futile cycling reaction in which C4a-hydroperoxyflavin at the active site decays to ... |
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| Engineering Considerations for Hydroxide Treatment of Training Ranges |
JUN 2007 |
99 pages |
| Authors:
Jeffrey L. Davis; Steven L. Larson; Deborah R. Felt; Catherine C. Nestler; W. A. Martin; LeeAnn Riggs; Edward J. Valente; G. R. Bishop; ENGINEER RESEARCH AND DEVELOPMENT CENTER VICKSBURG MS
|
| The use of hydrated lime has the potential to be an effective in situ technology for the destruction and containment of explosives contamination. This was proven with the results from the SERDP project CU-1230, where it was shown to rapidly degrade RDX and TNT. However, prior to field deployment of this technology additional experimental work was required to address concerns regarding the mechanism of the alkaline hydrolysis reaction, the character ... |
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| ON012380: A Non-ATP Competitive Inhibitor of BCR-ABL for the Therapy of Imatinib-Resistant CMLs |
MAY 2007 |
35 pages |
| Authors:
E. P. Reddy; TEMPLE UNIV PHILADELPHIA PA
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| Because it is now apparent that a significant proportion of patients chronically treated with imatinib develop resistance due to the acquisition of mutations in the kinase domain of BCR-ABL our aim was to generate a potent inhibitor of BCR-ABL by targeting regions outside the ATP binding site of this enzyme as these compounds offer the potential to be unaffected by mutations that make CML cells resistant to imatinib. Screening of ... |
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| Chemical Facility Security: Regulation and Issues for Congress |
26 MAR 2007 |
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| Authors:
Dana A. Shea; Todd B. Tatelman; LIBRARY OF CONGRESS WASHINGTON DC CONGRESSIONAL RESEARCH SERVICE
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| The Department of Homeland Security (DHS) has proposed security regulations for chemical facilities, implementing the statutory authority granted in the Homeland Security Appropriations Act, 2007 (P.L. 109-295, Section 550). The proposed regulations (71 Federal Register 78,276 78,332 (December 28, 2006)) require chemical facilities possessing amounts and types of substances considered by the DHS Secretary to be hazardous to notify DHS and undergo a consequence-based screening process. The Secretary would then ... |
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| Validation of Systems for Human Thermal Control |
19 MAR 2007 |
22 pages |
| Authors:
Ralph C. Sneed; CSA ENGINEERING INC MOUNTAIN VIEW CA
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| DARPA has invested substantial funds in the development of technologies for controlling the temperature of the warfighter. In hot environments, and in certain types of protective clothing and equipment, there is value in rapid removal of heat from the warfighter. In certain situation involving cold environments, including underwater ones, there is value in adding heat. One approach developed by Stanford University and others under DARPA funding makes use of heat ... |
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| Enhancing Quality of Life for Breast Cancer Patients with Bone Metastases |
01 MAR 2007 |
28 pages |
| Authors:
Sarah A. Arrington; Matthew J. Allen; Timothy A. Damron; Kenneth A. Mann; SYRACUSE UNIV RESEARCH FOUNDATION NY
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| The skeleton is the most common site of metastasis for women with advanced stage breast cancer (5, 8, 22). Severe osteolysis that is often associated with this stage of the disease can lead to skeletal related events such as pathological fracture severe bone pain and hypocalcaemia. The current standard of care for treating osteolytic bone metastases includes palliating bone pain through radiation therapy and blocking ongoing osteoclastic bone resorption with ... |
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