| Pressure-Sensitive Paint Data on the Facility Aerodynamics Validation and Research (FAVOR) Model at AEDC |
Dec-2009 |
|
| Authors:
Marvin E Sellers; ARNOLD ENGINEERING DEVELOPMENT CENTER ARNOLD AFS TN
|
 | Arnold Engineering Development Center (AEDC) recently acquired the Facility Aerodynamics Validation and Operations Research (FAVOR) model for use as a standard check model for Propulsion Wind Tunnel (PWT) 16T. The test article is a 5% scale model of the F-111 with new wings having a NACA 64-210 profile, a fixed sweep angle of 35 deg, and a span of 48 in. The plan is to periodically install the model and ... |
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| Unified Regional Tomography and Source Moment Tensor Inversions Based on Finite-Difference Strain Green Tensor Databases |
30-Sep-2009 |
11 pages |
| Authors:
Wei Zhang; Xiaoping Yang; Yang Shen; Li Zhao; Zhigang Zhang; SCIENCE APPLICATIONS INTERNATIONAL CORP SAN DIEGO CA
|
 | Seismic monitoring requires accurate source characterization in real time. Accurate 3D earth models are essential for accurate predictions of seismic observables and source characterization. While recovering the true earth structure has always been the goal of tomographic inversions, methods based on full wavefields in 3D reference models have several distinct advantages. Made possible by advances in high-performance computation, this full-wave approach accounts for complex wave propagation in 3D heterogeneous earth, ... |
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| Application of Dual-Tree Complex Wavelet Transforms to Burst Detection and RF Fingerprint Classification |
Sep-2009 |
150 pages |
| Authors:
Randall W Klein; AIR FORCE INST OF TECH WRIGHT-PATTERSON AFB OH GRADUATE SCHOOL OF ENGINEERING AND MANAGEMENT
|
| This work addresses various Open Systems Interconnection (OSI) Physical (PHY) layer mechanisms to extract and exploit RF waveform features (fingerprints) that are inherently unique to specific devices and that may be used to provide hardware specific identification (manufacturer, model, and/or serial number). This is addressed by applying a Dual-Tree Complex Wavelet Transform (DT-CWT) to improve burst detection and RF fingerprint classification. A Denoised VT technique is introduced to improve performance ... |
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| Robust Adaptive Control Using a Filtering Action |
Sep-2009 |
120 pages |
| Authors:
Jia-Horng Yang; NAVAL POSTGRADUATE SCHOOL MONTEREY CA
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| This dissertation describes the design of an adaptive controller for single-input single-output (SISO) systems with guaranteed bounds on the transient response, and robustness with external disturbances and unmodeled dynamics. Developed from a current approach called L1 adaptive controller, we show that by adding two properly designed low pass filters at the input and at the estimator we can control the transient response and the sensitivity of the overall system to ... |
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| Nearest Neighbor Classification Using a Density Sensitive Distance Measurement |
Sep-2009 |
120 pages |
| Authors:
Joshua J Burkholder; NAVAL POSTGRADUATE SCHOOL MONTEREY CA MODELING VIRTUAL ENVIRONMENTS AND SIMULATION (MOVES)
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| This work proposes a density sensitive distance measurement that takes into account the density of an underlying dataset to better represent the shape of the data when measuring distance. Kernel density estimation, using kernel bandwidths determined by k -nearest neighbor distances, is used to approximate the density of the underlying dataset. A scale is applied to the resulting kernel density estimate and a line integral is performed along its surface ... |
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| Optimizing the Air-to-Ground Kill Chain for Time-Sensitive Targets |
Sep-2009 |
74 pages |
| Authors:
Bradley A Bloye; NAVAL POSTGRADUATE SCHOOL MONTEREY CA DEPT OF OPERATIONS RESEARCH
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| When groups of platforms, sensors, and weapons are able to communicate with each other in real-time, they form a network. Modern warfare increasingly involves network-centric operations, the military strategy that seeks to translate informational advantages gained through the cooperation of all platforms in the network into increased overall mission effectiveness. For this thesis, the Time-to-Kill is our metric to quantify mission effectiveness because a given time-sensitive target is vulnerable to ... |
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| Particle Deposition onto Enclosure Surfaces |
20-Aug-2009 |
61 pages |
| Authors:
De-Ling Liu; AEROSPACE CORP EL SEGUNDO CA
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| In space applications, the main concern of particle deposition arises from the undesirable effects of surface obscuration on contamination-sensitive surfaces. The development of effective mitigation strategies to minimize particulate contamination requires the understanding of particle transport and deposition as well as the associated physical factors affecting the processes. The knowledge gleaned from the state-of-the-art literature review presented here can be applied to an enclosure scale as small as a spacecraft ... |
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| Quantum Sensors Program |
Aug-2009 |
82 pages |
| Authors:
Z Dutton; S Guha; N Stelmakh; M Vasilyev; P Kumar; F Wong; J Shaprio; G Deibner; G Burdge; H Yuen; J Habif; HARRIS CORP MELBOURNE FL
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| The resolution of a homodyne LADAR can be enhanced significantly by applying quantum optical techniques in the receiver. With a quantum image enhancer (QIE) inserted between the receive optics and the detector of a LADAR, an angular cell resolution improvement of 10x can be realized. The QIE is comprised of two key elements-a squeezed vacuum injector (SVI) that restores the high spatial frequencies lost by attenuation in soft-aperture entrance optics ... |
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| Epidemiology of Chronic Wasting Disease: PrPres Detection, Shedding, and Environmental Contamination |
Aug-2009 |
10 pages |
| Authors:
Randolph V Lewis; Michael W Miller; Terry Kreeger; WYOMING UNIV LARAMIE
|
| Chronic wasting disease (CWD) of deer and elk is unique among the transmissible spongiform encephalopathies. Our longterm goal is to better understand the epidemiology of CWD and thus develop strategies for management and control. The specific goals of these studies are to develop sensitive assays for PrPres as a marker for infectivity, and use these techniques to monitor the dynamics and modes of shedding of PrPres from orally infected mule ... |
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| Role of XIAP in Therapeutic Resistance in Inflammatory Breast Cancer |
Jul-2009 |
49 pages |
| Authors:
Katherine M Aird; DUKE UNIV DURHAM NC
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| Inflammatory breast cancer (IBC) is a highly aggressive form of locally advanced breast cancer that is often characterized by ErbB2 and ErbB1 overexpression. ErbB-targeting is clinically relevant using trastuzumab, an anti-ErbB2 antibody, and lapatinib, a small molecule ErbB1/2 kinase inhibitor. However, acquired resistance is common even in those patients who show an initial clinical response; this resistance is in part due to apoptotic dysregulation, which allows transformed cells to survive ... |
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| Altered MicroRNA Activity Promotes Resistance to Endocrine Therapy |
Jul-2009 |
42 pages |
| Authors:
Diana M Cittelly; COLORADO UNIV AURORA CO
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| MicroRNAs (miRNAs) have tumor suppressive and oncogenic potential in human cancer, but little is known about the extent at which miRNA expression is modified after anti-estrogen treatment and the contribution of specific miRNAs to the acquisition of anti-estrogen resistance. To answer this question, in Aim 1, we performed miRNA profiling of tamoxifen-resistant and sensitive breast cancer cells treated with Estradiol or Tam. Several miRNAs were intrinsically downregulated in tam-resistant cells ... |
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| Military and Dual-Use Technology. Covert Testing Shows Continuing Vulnerabilities of Domestic Sales for Illegal Export |
04-Jun-2009 |
27 pages |
| Authors:
Gregory D Kutz; GOVERNMENT ACCOUNTABILITY OFFICE WASHINGTON DC
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| GAO found that sensitive dual-use and military technology can be easily and legally purchased from manufacturers and distributors within the United States and illegally exported without detection. Using a bogus front company and fictitious identities, GAO purchased sensitive items including night-vision scopes currently used by U.S. soldiers in Iraq and Afghanistan to identify targets, triggered spark gaps used to detonate nuclear weapons, electronic sensors used in improvised explosive devices, and ... |
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| Polarimetric Imaging for the Detection of Disturbed Surfaces |
Jun-2009 |
77 pages |
| Authors:
Michael E Eyler; NAVAL POSTGRADUATE SCHOOL MONTEREY CA
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| This work tested the ability of the fast time-division SALSA polarimetric camera of Bossa Nova Technologies, Ltd. to distinguish disturbed from undisturbed surfaces. Earth and asphalt were imaged, and the data was processed using standard ENVI (trademark) software. The polarization signature of the disturbed earth was not strong, even when processing was employed. The camera was better able to distinguish between the polarization characteristics of patched or disturbed asphalt and ... |
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| MDA DS COI Spiral 3 - NOA, SILO and ABAC |
Jun-2009 |
82 pages |
| Authors:
Jay Spalding; Jim Harmon; Alistair Nicol; Mark MacKinnon; COAST GUARD RESEARCH AND DEVELOPMENT CENTER GROTON CT
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| The purpose of this report is to document United States Coast Guard (USCG) Research and Development (R&D) efforts in support of the Maritime Domain Awareness Data Sharing Community of Interest (MDA DS COI) Spiral 3 Project. The project focuses on sharing the sensitive data associated with Notice of Arrival (NOA) messages and the Single Integrated LookOut (SILO) list in a net-centric Web-services environment. It documents the background of the efforts ... |
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| Design of Energetic Ionic Liquids |
12-May-2009 |
9 pages |
| Authors:
Sharon Hammes-Schiffer; Jerry A Boatz; Mark S Gordon; Gregory A Voth; AIR FORCE RESEARCH LAB EDWARDS AFB CA PROPULSION DIRECTORATE
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| An essential need of the US Air Force is the discovery, development, and fielding of new, energetic materials for advanced chemical propulsion in space and missile applications. Some of the key factors driving the requirement for new chemical propellants include: (a) improved performance in terms of increased specific impulse and density, (b) reduced sensitivity to external stimuli such as impact, friction, shock, and electrostatic discharge, and (c) mitigation of environmental ... |
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| Spectroscopy and Dynamics of Transient and Energetic Species |
Apr-2009 |
14 pages |
| Authors:
Daniel M Neumark; CALIFORNIA UNIV BERKELEY DEPT OF CHEMISTRY
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| Free radicals, weakly bound van der Waals complexes, and metal and semiconductor clusters are characterized by photodetachment of the corresponding negative ions using slow electron velocity-map imaging (SEVI), a recently developed, high-resolution (2-3 cm-1) variant of negative ion photoelectron spectroscopy. The SEVI spectrum of a negative ion yields the electron affinity of the neutral, term values for excited states accessible via one-photon detachment, and accurate vibrational frequencies for the ground ... |
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| Real-Time Detection of Chemical Warfare Agents Using Multi-Wavelength Photoacoustics |
Apr-2009 |
18 pages |
| Authors:
Melvin Felton; Kristan Gurton; Richard Tober; ARMY RESEARCH LAB ADELPHI MD COMPUTATIONAL AND INFORMATION SCIENCES DIRECTORATE
|
| We present a proof-of-concept study designed to investigate the utility of operating a conventional photoacoustic spectroscopy technique in a multi-wavelength mode applied to chemical vapor/aerosols for application of trace species detection and identification. The technique involves propagating three or more laser sources through a non-resonate, flow through photoacoustic cell. Each laser source is modulated at a different frequency, chosen at some convenient acoustic frequency. A portion of each laser's power ... |
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| Electronic Imaging and Signal Processing Toward Realistic Night-Vision Simulation |
29-Mar-2009 |
|
| Authors:
Maarten Hogervorst; TNO DEFENCE SECURITY AND SAFETY SOESTERBERG (NETHERLANDS)
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| A novel color-transformation method converts daytime scenes into night-vision goggle images suitable for realistic nighttime training. To date, nighttime training using flight or driving simulators has been hindered by the lack of typical night-vision goggle (NVG) rendering. NVG performance is often simulated in training vehicles by converting daytime images into black and white, and displaying the resulting scene in green. However, this approach does not consider that NVG images are ... |
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| Environmental Variation in Contamination Outgas Testing of a Composite Material |
15-Mar-2009 |
30 pages |
| Authors:
Keith R Olson; Kelsey A Folgner; AEROSPACE CORP EL SEGUNDO CA
|
| Molecular contamination degrades sensitive spacecraft surfaces and can adversely affect the useful life of a spacecraft. In order to accurately predict mission performance, a thorough understanding of the emission and condensation of potential spacecraft contaminants is necessary. Potential sources of contamination include composite materials that are often used for large structural components. The large mass of these composite structures can represent the largest outgassing source on a spacecraft. This report ... |
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| BRCA1 in Gene-specific Coordination of Transcription and DNA-Damage Response |
14-Mar-2009 |
9 pages |
| Authors:
Jianlong Sun; TEXAS UNIV HEALTH SCIENCE CENTER AT SAN ANTONIO
|
| BRCA1 is a tumor suppressor gene for hereditary breast and ovarian cancers. In collaborating with various binding partners, BRCA1 protein participates in multiple cellular functions. Characterization of these binding proteins of BRCA1 is therefore key to the complete understanding of BRCA1's role in tumor suppression. Cofactor of BRCA1 (COBRA1) is a novel BRCA1-interacting protein and shares several functional commonalities with BRCA1 in regulating expression of genes involved various types of ... |
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| Development and Production of a Leishmania Skin Test |
Mar-2009 |
183 pages |
| Authors:
Neilsen; Harry S Jr; ALLERMED LABS INC SAN DIEGO CA
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| Further refinement of the manufacturing process of Leishmania tropica Skin Test Antigen (LtSTA) was made during this contract period to increase the yield and robustness of the parasite during culture. Identity and potency tests for LtSTA were developed and the procedures are being validated. The analysis of dose-response, safety and efficacy data from a phase II clinical trial conducted in Sidi Bouzid, Tunisia in 2007 were compiled and analyzed, and ... |
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| Proof-of-Concept Studies in Novel Guided Wave Methods for Metallic Structural Condition |
Mar-2009 |
40 pages |
| Authors:
Michael Lanza di Todd; Francesco Scalea; CALIFORNIA UNIV SAN DIEGO LA JOLLA
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| Active sensing in structural health monitoring (SHM) refers to injecting (user-defined) energy into the system in order to actively probe its response to the induced dynamics as a means of detecting whether damage may be present in the system. A number of researchers have shown that active sensing with guided ultrasonic waves (GUWs) can be a powerful approach to take, as GUWs, when launched and detected in conjunction with macro-fiber ... |
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| Polymer Drag Reduction and Bioluminescence Reduction |
Mar-2009 |
9 pages |
| Authors:
Michael I Latz; CALIFORNIA UNIV REGENTS SAN DIEGO LA JOLLA CA
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| Drag reducing polymers interfere with the bursting process in turbulence by absorbing the energy like a shock absorber. The objective of this project was to test the effect of the polymer drag reducing agent polyethylene oxide (PEO) on bioluminescence stimulation in fully-characterized pipe flow. The well-documented reduction of turbulent skin friction by PEO was hypothesized to also result in a similar reduction of flow-stimulated bioluminescence. Drag reduction and bioluminescence suppression ... |
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| The Role of Backup NHEJ Repair in Creating Genomic Instability in CML. Addendum |
Mar-2009 |
18 pages |
| Authors:
Feyruz Rassool; MARYLAND UNIV BALTIMORE SCHOOL OF MEDICINE
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| The BCR-ABL1 fusion gene in Philadelphia (Ph)-+ve chronic myeloid leukemis (CML) encodes a constitutively active tyrosine kinase that causes uncontrolled cellular proliferation. BCR-ABL1 expression results in elevated levels of reactive oxygen species (ROS), an increased incidence of DNA double strand breaks (DSBs), error-prone repair and genomic instability. We recently demonstrated that an error-prone alternative (alt) NHEJ pathway involving DNA ligase IIIa/XRCC1 is upregulated in CML cells. Knockdown of alt NHEJ ... |
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| Magnetic Field Probes for use in Radio Frequency Plasma (Preprint) |
24-Feb-2009 |
15 pages |
| Authors:
William Lewis; Michael P Reilly; George H Miley; ILLINOIS UNIV AT URBANA-CHAMAPAIGN
|
| An impedance analyzer has been used in the characterization of a magnetic induction probe (B-dot probe) for use in plasma. The role of the impedance analyzer was to determine the frequency response of a B-dot probe up to 100 MHz. The probe was specifically designed to take measurements in RF plasma driven at 13.56 MHz. Probe sensitivity and calibration are considered based on the impedance values obtained when a B-dot ... |
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| Exploratory Corrugated Infrared Hot-Electron Transistor Arrays |
Feb-2009 |
18 pages |
| Authors:
Kwong-Kit Choi; Richard Fu; Kimberly Olver; ARMY RESEARCH LAB ADELPHI MD SENSORS AND ELECTRON DEVICES DIRECTORATE
|
| In this study, we investigated a 5x8 corrugated infrared hot-electron transistor (IHET) array with a common base configuration. We found the IHET structure improved the photocurrent-to-dark current ratio by a maximum factor of six compared to the basic quantum well infrared photodetector (QWIP) structure. This improvement is consistent with the hot-electron distributions created by the thermal and photo-excitations within the detectors. The study also showed that there is no electrical ... |
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| Determination of Etomidate in Human Postmortem Fluids and Tissues |
Feb-2009 |
14 pages |
| Authors:
Robert D Johnson; Russell J Lewis; FEDERAL AVIATION ADMINISTRATION OKLAHOMA CITY OK CIVIL AEROSPACE MEDICAL INST
|
| Following an aviation accident, biological specimens from the operator of the aircraft are submitted to the Federal Aviation Administration's Civil Aerospace Medical Institute for toxicological analysis. During the course of medical treatment following an aviation accident, pilots who later died as a result of their injuries may have been administered etomidate as an intravenous anesthetic. Our laboratory has developed a sensitive method for the identification and quantitation of etomidate in ... |
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| Transfer and Generalizability of Foreign Language Learning |
Feb-2009 |
32 pages |
| Authors:
Allison Abbe; ARMY RESEARCH INST FOR THE BEHAVIORAL AND SOCIAL SCIENCES ARLINGTON VA
|
| Knowing a foreign language provides an advantage for understanding, working in, and building relationships with a particular language community. However, military personnel can expect to encounter multiple languages in their operational experiences over a career. Thus, it is important to understand what impact learning a foreign language has beyond its applications with a specific population. This report reviews research on the extent to which foreign language proficiency facilitates further language ... |
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| Collisional Decoherence in Trapped-Atom Interferometers that use Nondegenerate Sources |
22-Jan-2009 |
9 pages |
| Authors:
Steven Miller; James A Stickney; Matthew B Squires; James Scoville; Paul Baker; AIR FORCE RESEARCH LAB HANSCOM AFB MA SPACE VEHICLES DIRECTORATE
|
| The coherence time, and thus sensitivity, of trapped atom interferometers that use non-degenerate gases are limited by the collisions between the atoms. An analytic model that describes the effects of collisions between atoms in an interferometer is developed. It is then applied to an interferometer using a harmonically trapped non-degenerate atomic gas that is manipulated with a single set of standing wave laser pulses. The model is used to find ... |
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| Dynamic Models Including Uncertainty |
22-Jan-2009 |
28 pages |
| Authors:
H T Banks; NORTH CAROLINA STATE UNIV AT RALEIGH CENTER FOR RESEARCH IN SCIENTIFIC COMPUTATION
|
| In this 10-month funded effort, we report progress on the development of methods in a number of specific areas: stochastic and deterministic models for complex networks and development of inverse problem methodologies (generalized sensitivity functions). These efforts are part of our continuing fundamental research program in modeling, estimation and control methodology) theoretical, statistical and computational) for systems in the presence of major model observation uncertainties. |
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| Development of a Multi-Scale Methodology for Prediction of the Microscopic Anisotropic Stress-Strain Response of Textured Metals under Dynamic Loading |
21-Jan-2009 |
69 pages |
| Authors:
Oana Cazacu; FLORIDA UNIV SHALIMAR DEPT OF MECHANICAL AND AEROSPACE ENGINEERING
|
| This report documents a comprehensive experimental and theoretical investigation of the deformation behavior of high-purity, polycrystalline alpha-titanium. A series of monotonic uniaxial compression and tension tests were carried out at room temperature under quasi-static conditions to quantify the plastic anisotropy and the tension-compression asymmetry of this material. The evolution of microstructure and texture during deformation was studied using optical image microscopy (OIM) and neutron-diffraction techniques to elucidate the role of ... |
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| Vibrotactile Sensitivity of the Head |
Jan-2009 |
28 pages |
| Authors:
Kimberly Myles; Joel T Kalb; ARMY RESEARCH LAB ABERDEEN PROVING GROUND MD HUMAN RESEARCH AND ENGINEERING DIRECTORATE
|
| The brain rarely processes events of the physical world using signals from a single sensory modality. While the visual and auditory modalities are considered frequently in communication research, the tactile modality is considered the least as a possible mode of communication. In addition, previous studies of tactile sensitivity and solutions in utilizing the tactile modality have been focused on torso and limb locations. However, there are currently no tactile sensitivity ... |
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| Intermolecular Slip Mechanism in Tropocollagen Nanofibrils |
Jan-2009 |
8 pages |
| Authors:
Markus J Buehler; Alfonso Gautieri; Simone Vesentini; Alberto Redaelli; MASSACHUSETTS INST OF TECH CAMBRIDGE OFFICE OF SPONSORED RESEARCH
|
| Collagen is the most important structural protein in the animal kingdom and is responsible for the strength and integrity of many tissues like bone, teeth, cartilage and tendons. The mechanical properties of these tissues are determined by their hierarchical structure. However, how each level contributes to the overall properties of collagenous tissues, and how individual hierarchical levels interact, remains poorly understood. Furthermore, despite extensive experimental and computational studies including both ... |
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| Responsive Polymer Interfaces |
02-Dec-2008 |
11 pages |
| Authors:
Alfred J Crosby; MASSACHUSETTS UNIV AMHERST MA OFFICE OF GRANT AND CONTRACT ADMIN
|
| This project focused on the fabrication and characterization of responsive polymer interfaces to be used as smart coatings that dynamically alter surface properties, advanced optical devices, and/or sensors. Transition speed, magnitude of change, and sensitivity are primary challenges in the development of responsive surfaces. To meet these challenges, we developed polymer surfaces with controlled shell structures that transition via snap-through or crumpling elastic instabilities upon the application of a trigger. ... |
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| Aptamer Selection Express: A Novel Method for Rapid Single-Step Selection and Sensing of Aptamers |
Dec-2008 |
10 pages |
| Authors:
Maomian Fan; Shelly Roper; Carrie Andrews; Amity Allman; John Bruno; Jonathan Kiel; CONCEPTUAL MINDWORKS INC SAN ANTONIO TX
|
| This article describes a new DNA capture element (DCE) sensing system, based on the quenching and dequenching of a double-stranded aptamer. This system shows very good sensitivity and thermal stability. While quenching, dequenching, and separating the DCE systems made from different aptamers (all selected by SELEX), an alternative method to rapidly select aptamers was developed the Aptamer Selection Express (ASExp). This process has been used to select aptamers against different ... |
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| Comparison of NDTI Methodologies to Classify Infrastructure in an Urban Battlespace From Thermal IR Signatures |
Dec-2008 |
9 pages |
| Authors:
Robert Lozar; Michael McInerney; Jonathan Trovillion; ENGINEER RESEARCH AND DEVELOPMENT CENTER CHAMPAIGN IL CONSTRUCTION ENGINEERING RESEARCH LAB
|
| A major challenge of remote infrastructure classification is to distinguish pavements from roofs. We proposed that, due to their differing thermal masses, these elements will heat and cool differently. Therefore, their thermal infrared (IR) signatures will differ throughout a 24-hour cycle. We propose a method to rapidly identify urban infrastructure that will assist the Future Force in dominating the urban battlespace to the same degree that the current force dominates ... |
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| A New Kind of Laser Microphone for Photoacoustic Applications |
Dec-2008 |
8 pages |
| Authors:
Feng Jin; Sudhir Trivedi; Chen-Chia Wang; V Swaminathan; Narasimha S Prasad; ARMY ARMAMENT RESEARCH DEVELOPMENT AND ENGINEERING CENTER PICATINNY ARSENAL NJ
|
| We present in this paper a new kind of laser-based microphone device capable of detecting minute displacements of the microphone diaphragm, leading to drastically improved sensitivity in detecting the impinging pressure waves like acoustic waves and water waves over existing state-of-the-art laser and fiber-optic microphones. The drastically improved sensitivity in detecting diaphragm surface displacements of the novel laser microphone leads to niche applications including the photoacoustic detection of molecules and ... |
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| Microfluidic/SERS Detection of Trace Explosives |
Dec-2008 |
7 pages |
| Authors:
Carl Meinhart; Brian Piorek; Seung J Lee; Martin Moskovits; Craig Cummings; CALIFORNIA UNIV SANTA BARBARA DEPT OF MECHANICAL ENGINEERING
|
| We have developed a chemical detector combining Free-Surface microfluidics (FSF) with surface-enhanced Raman spectroscopy (SERS) to measure air-borne molecules with extremely high sensitivity (parts per trillion) and molecular specificity. The free-surface of a microfluidic material stream allows polar airborne molecules to absorb directly into a microchannel flow, and provides a barrier to non-polar, water insoluble airborne molecules. Explosives molecules are polar and readily absorb into the microchannel flow, whereas many ... |
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| Development of a Tissue Engineered Scaffold for Meniscus Replacement |
Dec-2008 |
8 pages |
| Authors:
E A Balint; Gatt; C J Jr; M G Dunn; ROBERT WOOD JOHNSON UNIV HOSPITAL NEW BRUNSWICK NJ
|
| It is well accepted that the loss of meniscal function due to surgical removal is a significant factor in the onset of degenerative osteoarthritis of the knee. Few viable alternatives exist for the replacement of significantly damaged tissue. In this study, two potential designs for meniscus scaffolds were compared with a focus on the mechanical protection they provide the articular surfaces and their overall biological incorporation into synovial tissue. Three ... |
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| Preparation of Insensitive RDX From Crude RDX Using an Antisolvent Phase Separation Process |
Dec-2008 |
4 pages |
| Authors:
Reddy Damavarapu; Veera M Boddu; Abburi Krishnaiah; CONSTRUCTION ENGINEERING RESEARCH LAB (ARMY) CHAMPAIGN IL
|
| This paper describes the separation of two of the most widely used explosive compounds, RDX (1,3,5-Trinitro-1,3, 5-triazacyclohexane) and HMX (1,3,5,7-tetranitro-1,3,5,7- tetraazacyclooctane). A simple antisolvent phase separation process to obtain more than 99 % pure RDX from an explosive mixture consisting of RDX (approx. 90 %) and HMX (approx. 10 %) was developed. The process does not require modifications to the existing RDX manufacturing process, and only minimal amounts of new ... |
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| Labeled Antimicrobial Peptides for Detection of Microorganisms |
Dec-2008 |
10 pages |
| Authors:
Steven Arcidiacono; Philip Pivarnik; Alexa Meehan; Charlene Mello; Andre Senecal; ARMY NATICK SOLDIER RESEARCH DEVELOPMENT AND ENGINEERING CENTER MA
|
| Antibodies have traditionally been used for pathogen detection but often lack stability and sensitivity. Current biosensor technologies using fluorescently labeled antibodies are generally capable of detection of 10(exp 3) to 10(exp 4)4 bacterial cells/ml. Antimicrobial peptides naturally bind to the lipopolysaccharide component of bacterial cell walls as part of their mode of action. Fluorescently labeled antimicrobial peptides (AMPs) were evaluated as a potential replacement of labeled antibodies in a sandwich ... |
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| Reversible Polymer Hydrogels |
Dec-2008 |
4 pages |
| Authors:
V M Boddu; N Naismith; H Patel; R C Flowers; ENGINEER RESEARCH AND DEVELOPMENT CENTER CHAMPAIGN IL CONSTRUCTION ENGINEERING RESEARCH LAB
|
| Temperature sensitive hydrogels based on N-isopropyl acrylamide (NIPA) and acryloyl glucosamine (AG) were synthesized using ammonium persulfate (APS) as initiator, N,N,N',N' -tetramethylenediamene (TEMED) as activator, and N,N'-methylene bisacrylamide (BIS) as cross-linker. The hydrogels were characterized using FTIR spectral analysis to investigate the chemical composition of the hydrogels. Swelling studies of the gel in water at room temperature to relate the swelling characteristics to the chemical composition were conducted. Further, the ... |
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| Decision Modeling for Smart Climatology |
30-Nov-2008 |
62 pages |
| Authors:
Eva Regnier; NAVAL POSTGRADUATE SCHOOL MONTEREY CA DEFENSE RESOURCES MANAGEMENT INST
|
| The purpose of smart climatology is to provide information that would be useful in operational planning at lead times of two to four weeks or greater. Decisions made at shorter lead-times are generally informed by forecasts. One of the challenges in designing a new climatology data system -- to include generation, storage, and access -- is anticipating how the data might be used, and therefore how to design the system ... |
|
| MT 2A Phosphorylation by PKC Mu/PKD Influences Chemosensitivity to Cisplatin in Prostate Cancer |
Nov-2008 |
32 pages |
| Authors:
Kethandapatti C Balaji; MASSACHUSETTS UNIV MEDICAL SCHOOL WORCESTER
|
| We showed that zinc treatment induced MT expression in LNCaP and C4-2 PCa cells as determined by Western blotting and DNA microarray analysis. Chemotherapy and radiation sensitivity assays of cells after treatment with cisplatin or radiation were performed in the presence, or absence, of 150 microM ZnSO4, and cell viability was measured after 72 hours by MTS viability and clonogenic and flow cytometry assays. The experiments were repeated three times ... |
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| Controls Over the Contractor Common Access Card Life Cycle |
10-Oct-2008 |
104 pages |
| Authors:
Paul J Granetto; Anthony M Torres; David M Staley; Thomas T Nguyen; Hanh T Nguyen; Michael D Durda; Dewayne J Jr; McOsker; Melinda M Oleksa; Carol N Gorman; Donald A Bloomer; Christopher S Groubert; OFFICE OF THE DEPUTY INSPECTOR GENERAL FOR AUDITING OF THE DEPARTMENT OF DEFENSE ARLINGTON VA
|
| The overall objective of this audit was to determine whether controls over Common Access Cards (CACs) provided to contractors were in place and worked as intended. Specifically, we determined whether DoD officials issued CACs to contractors, verified the continued need for contractors to possess CACs, and revoked and recovered CACs from contractors in accordance with DoD policies and procedures. |
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| Prostate Cancer Progression and Serum Sibling (Small Integrin Binding N-Linked Glycoprotein) Levels |
01-Oct-2008 |
154 pages |
| Authors:
Neal S Fedarko; JOHNS HOPKINS UNIV BALTIMORE MD
|
| We have been studying a gene family termed SIBLINGs (for small integrin binding ligand N-linked glycoproteins) whose members include bone sialoprotein (BSP), osteopontin (OPN), dentin matrix protein-1 (DMP1), dentin sialophosphoprotein (DSPP) and matrix extracellular phosphoglycoprotein (MEPE). Our Specific Aims are to describe the distribution of serumbased measurements of SIBLINGs among (a) normal individuals, (b) individuals with benign prostatic disease, (c) individuals with clinically defined prostate cancer, and (d) longitudinal samples ... |
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| Permalloy Film Array Spin Dynamics and High Performance Integrated Microwave Devices |
25-Sep-2008 |
8 pages |
| Authors:
Pingshan Wang; CLEMSON UNIV SC OFFICE OF SPONSORED PROGRAM
|
| Major contributions of this project include (1) the highest permalloy (Py) array FMR frequency reported so far without DC magnetic bias field, and (2) an ultra-sensitive method for ferromagnetic material characterization. Shape-induced high frequency properties of patterned submicron Py arrays are obtained. Py films are sputtered and patterned on gold (Au) transmission lines. Chromium (Cr) is used as adhesion layers for Au and Py deposition. Each Py bar in the ... |
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| Smart Climatology Applications for Undersea Warfare |
01-Sep-2008 |
117 pages |
| Authors:
Allon Turek; NAVAL POSTGRADUATE SCHOOL MONTEREY CA
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| Undersea warfare operations especially sound navigation and ranging (SONAR) are sensitive to small changes in the ocean environment. Variations in both atmospheric and oceanic conditions on monthly to decadal scales can have significant impacts on U.S. Navy operations in the undersea environment. Climate databases presently used in U.S. Navy tactical decision aids (TDAs) are based on less than optimal data sets and long term mean (LTM) climatologies that are unable ... |
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| HER2/Leptin Crosstalk in Breast Cancer |
Sep-2008 |
27 pages |
| Authors:
Eva Surmacz; TEMPLE UNIV PHILADELPHIA PA
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| Obesity in postmenopausal women is associated with increased breast cancer risk, development of more aggressive tumors and resistance to certain anti-breast cancer treatments. These effects might be mediated by obesity hormone leptin. Here we tested if leptin can transactivate the oncogenic receptor HER2. We found that HER2 and the leptin receptor (ObR) are coexpressed in several studied breast cancer cell lines. In MCF-7 cells, HER2 physically interacted with ObR and ... |
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| Target Picking Methods for Magnetic Data |
Sep-2008 |
39 pages |
| Authors:
AETC INC ARLINGTON VA
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| Due to the large numbers (up to tens of thousands) of possible targets identified in nominal unexploded ordnance (UXO) surveys, efficient and reliable machine-aided target pickers should be used to identify targets for subsequent characterization. When selecting anomalies, the goal is to identify all anomalous features that may be caused by UXO, while minimizing operator time and eliminating operator bias. To facilitate advanced physics-based modeling, however, the target pickers should ... |
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