| Control Based Mobile Ad Hoc Networking for Survivable, Dynamic, Mobile Special Operation Force Communications |
Sep-2009 |
91 pages |
| Authors:
Marion McBride; Mustafa Masacioglu; NAVAL POSTGRADUATE SCHOOL MONTEREY CA
|
 | In the next generation of wireless communication systems, there will be a need for the rapid deployment of independent mobile users. Significant examples include establishing survivable, efficient, dynamic mobile communication for tactical Special Operation Force (SOF) networks, as well as SOF units that are ad hoc networking with first responders conducting emergency/rescue and disaster relief operations. Such network scenarios cannot rely on centralized and organized connectivity, and should instead employ ... |
|
| Finding the Sweet Spot for Catastrophic Incident Search and Rescue |
Sep-2009 |
164 pages |
| Authors:
Eric M Bleakney; NAVAL POSTGRADUATE SCHOOL MONTEREY CA CENTER FOR HOMELAND DEFENSE AND SECURITY
|
| This thesis examines the national preparedness to conduct catastrophic incident search and rescue (SAR) using organization-specific doctrine, concept plans, congressional research reports and testimonies, after action reviews, periodicals, federal government plans, interviews, a focus group and two benchmark studies. The research indicates that individual organizations conduct SAR activities well, but combined, joint and interagency catastrophic search and rescue preparations are lacking. Should another catastrophic incident occur tomorrow, the SAR results ... |
|
| The Effects of the Joint Multi-Mission Electro-Optical System on Littoral Maritime Intelligence, Surveillance, and Reconnaissance Operations |
Sep-2009 |
164 pages |
| Authors:
Bronchae M Brown; Brian L Schulz; NAVAL POSTGRADUATE SCHOOL MONTEREY CA DEPT OF INFORMATION SCIENCES
|
| The United States Department of Defense finds itself in a period of reduced resources and growing requirements. In the field of Intelligence, Surveillance, and Reconnaissance (ISR), there have been calls for both manpower and system cuts, while collection requirements continue to increase. One proposed method for maximizing ISR collection efforts is the development of multi-mission capable collection equipment. In support of this concept, BAE Systems has developed the Joint Multi-Mission ... |
|
| Checkpoint Functions of the BRCA1/BARD1 Tumor Suppressor |
Jul-2009 |
34 pages |
| Authors:
Ami Modi; COLUMBIA UNIV NEW YORK
|
| The tumor suppressor BRCA1 has been implicated in numerous cellular processes, including cell cycle checkpoint control, DNA repair, and mitotic spindle assembly. In vivo, BRCA1 primarily exists in association with BARD1, and the BRCA1/BARD1 heterodimer is thought to mediate the tumor suppression activity of BRCA1. It has been shown that the phosphorylation state of the BARD1 polypeptide is cell- cycle regulated and that BARD1 is hyperphosphorylated in mitosis at seven ... |
|
| Trafficking in Persons Report |
Jun-2009 |
325 pages |
| Authors:
DEPARTMENT OF STATE WASHINGTON DC
|
| The Department of State is required by law to submit each year to the U.S. Congress a report on foreign governments' efforts to eliminate severe forms of trafficking in persons. This is the 9th annual TIP Report; it seeks to increase global awareness of the human trafficking phenomenon by shedding new light on various facets of the problem and highlighting shared and individual efforts of the international community, and to ... |
|
| Enhancement of Skeletal Muscle Repair by the Urokinase Type Plasminogen Activator System |
Jan-2009 |
8 pages |
| Authors:
Timothy J Koh; ILLINOIS UNIV AT CHICAGO
|
| Skeletal muscle injuries, caused by intense exercise or trauma, are among the most common injuries in military personnel. Enhancement of muscle repair following injury would minimize time lost and maximize performance during training and combat. We and others have published data demonstrating that the extracellular protease urokinase-type plasminogen activator (uPA) is required for efficient muscle repair, although the underlying mechanisms remain to be elucidated. In this progress report, we present ... |
|
| Multi-Robot Systems in Military Domains (Les Systemes Multi-Robots Dans les Domaines Militaires) |
Dec-2008 |
|
| Authors:
NATO RESEARCH AND TECHNOLOGY ORGANIZATION NEUILLY-SUR-SEINE (FRANCE)
|
 | IST-032/RTG-014 aim was to consider the potential of modern multi-robot systems for the use in military domains. There has been substantial interest in the use of MRS for a variety of military purposes. A better understanding of human computer and/or robot interaction requirements and development of techniques for evaluating the effectiveness of MRS to meet military purposes will provide military users with a basis for determining their requirements for this ... |
|
| Scalable Emergency Response System for Oceangoing Assets Report on Defining Proposed Program |
17-Oct-2008 |
50 pages |
| Authors:
Edmond J Dougherty; ABLAZE DEVELOPMENT CORP VILLANOVA PA
|
| The scalable emergency system is intended to cover the full scale of possible at-sea incidents from the routine to the rare; from the detection and decontamination of a single piece of equipment before it is loaded on a vessel, to the response, rescue, containment and rehabilitation of a vessel in open waters. The system will be able to safely and quickly decontaminate cargo and personnel, as well as entire vessels ... |
|
| Validation of High Frequency Radar Used in Ocean Surface Current Mapping via in-situ Drifting Buoys |
01-Sep-2008 |
110 pages |
| Authors:
George Wright; NAVAL POSTGRADUATE SCHOOL MONTEREY CA
|
| High frequency (HF) radar and its application to mapping ocean surface currents is a relatively new field of study in oceanography. Nevertheless, this scientific field produces real, tangible, accurate real-time results readily available to the military operational planner. The information gained through this process aids in the planning and execution of littoral operations via the development of the battle-space environment. Additionally, commercial use of this information can aide in the ... |
|
| Wireless Robotic Communications in Urban Environments: Issues for the Fire Service |
MAR 2008 |
169 pages |
| Authors:
George Hough; NAVAL POSTGRADUATE SCHOOL MONTEREY CA
|
| Firefighters are tasked with conducting search and rescue operations at incidents ranging from minor smoke conditions to multi-agency disasters. In each instance, a rapid risk assessment must be conducted based on preliminary dispatch information. Small lightweight man portable robots are a natural fit for gaining improved situational awareness, yet few have been employed for this application. The problems encountered in using wireless robots in urban environments are among the primary ... |
|
| Enhancement of Skeletal Muscle Repair by the Urokinase Type Plasminogen Activator System |
01-Jan-2008 |
8 pages |
| Authors:
Timothy J Koh; ILLINOIS UNIV AT CHICAGO
|
| Skeletal muscle injuries, caused by intense exercise or trauma, are among the most common injuries in military personnel. Enhancement of muscle repair following injury would minimize time lost and maximize performance during training and combat. We and others have published data demonstrating that the extracellular protease urokinase-type plasminogen activator (uPA) is required for efficient muscle repair, although the underlying mechanisms remain to be elucidated. In this progress report, we present ... |
|
| Pentagon 9/11 |
SEP 2007 |
320 pages |
| Authors:
Alfred Goldberg; Sarandis Papadopoulos; Diane Putney; Nancy Berlage; Rebecca Welch; OFFICE OF THE SECRETARY OF DEFENSE WASHINGTON DC HISTORICAL OFFICE
|
| As no other event in U.S. history, not even Pearl Harbor, the deadly assaults on New York and Washington that took the lives of almost 3,000 people on 11 September 2001 shattered the nation's sense of security. The utter destruction of the Twin Towers in New York and the severe damage done to the Pentagon by Middle East terrorists signaled a changed world in the making, one that poses a ... |
|
| Investigating Team Collaboration of the Fire Department of New York Using Transcripts from September 11, 2001 |
JUN 2007 |
195 pages |
| Authors:
Maura Garrity; NAVAL POSTGRADUATE SCHOOL MONTEREY CA
|
| On September 11, 2001, more than one thousand people responded to aid in rescue efforts at the World Trade Center in New York City, mobilizing the largest rescue operation in the city's history. The collaborative teamwork demonstrated in this response is recorded in the radio transcripts between responding units and the Manhattan Dispatcher. The goal of this thesis is to use these transcripts to provide a real world example to ... |
|
| Scalable Emergency Response System for Oceangoing Assets Report on Brainstorming Concept Evaluations |
11-Apr-2007 |
87 pages |
| Authors:
Edmond J Dougherty; ABLAZE DEVELOPMENT CORP VILLANOVA PA
|
| The scalable emergency system is intended to cover the full scale of possible at-sea incidents from the routine to the rare; from the detection and decontamination of a single piece of equipment before it is loaded on a vessel, to the response, rescue, containment and rehabilitation of a vessel in open waters. The system will be able to safely and quickly decontaminate cargo and personnel, as well as entire vessels ... |
|
| Defense Support of Civil Authorities - Are We Organized Right? |
30 MAR 2007 |
38 pages |
| Authors:
Joseph Austin; ARMY WAR COLL CARLISLE BARRACKS PA
|
| The Department of Defense (DoD) has a long history of supporting civil authorities in the wake of catastrophic events with specialized skills and assets that can rapidly stabilize and improve the situation. An issue that has received a great amount of attention in post-Hurricane Katrina discussions is the speed of rescue and relief operations. Both the National Response Plan and DoD's own Homeland Security Doctrine lay out extensive procedures and ... |
|
| Stochastic Mapping for Chemical Plume Source Localization With Application to Autonomous Hydrothermal Vent Discovery |
FEB 2007 |
|
| Authors:
Michael V. Jakuba; WOODS HOLE OCEANOGRAPHIC INSTITUTION MA
|
| This thesis presents a stochastic mapping framework for autonomous robotic chemical plume source localization in environments with multiple sources. Potential applications for robotic chemical plume source localization include pollution and environmental monitoring, chemical plant safety, search and rescue, anti-terrorism, narcotics control, explosive ordinance removal, and hydrothermal vent prospecting. Turbulent flows make the spatial relationship between the detectable manifestation of a chemical plume source, the plume itself, and the location of ... |
|
| Technology Development for a Multi-Mission Passive EO/IR Turret Applied to Maritime Search and Rescue |
22 JAN 2007 |
22 pages |
| Authors:
George Moe; VISTA RESEARCH INC SUNNYVALE CA
|
| The objective of this project is to develop polarization and sea foam mitigation techniques and camera components to improve the performance and reduce the form factor of turreted passive multi-spectral imaging systems, with specific application to an existing sensor system known as EPAS, for electro-optic passive ASW system. The work under this contract was focused on the application of this sensor system to Maritime Search and Rescue. The relative merits ... |
|
| A Signal Detection Model of Compound Decision Tasks |
DEC 2006 |
|
| Authors:
Matthew Duncan; DEFENCE RESEARCH AND DEVELOPMENT TORONTO (CANADA)
|
| Detection and identification represent two fundamental types of decision tasks. Although research has focused on each in isolation, the pure forms of these tasks are generally not representative of more complex naturalistic decision environments. For example, a decision maker involved in a Search and Rescue (SAR) operation is faced with locating and identifying a crash site. This kind of decision environment is characterized by both detection and identification components. That ... |
|
| Disarming the Bearer of the Sword: Delinking the Abu Sayyaf From the Global Insurgency |
23 OCT 2006 |
23 pages |
| Authors:
Elmer Nagma; NAVAL WAR COLL NEWPORT RI JOINT MILITARY OPERATIONS DEPT
|
| On May 27, 2001, the Abu Sayyaf Group (ASG), an Al Qaeda affiliate, gained worldwide notoriety when it attacked a popular vacation resort on the Philippine island of Palawan. Thirty tourists were kidnapped for ransom. One of the vacationers, Guillermo Sobero, was an American from Corona, California. Weeks after the kidnapping the ASG announced it had beheaded Sobero. Also abducted was an American missionary couple, Martin and Gracia Burnham of ... |
|
| Ultrasound Guidance as a Rescue Technique for Peripheral Intravenous Cannulation |
14 SEP 2006 |
16 pages |
| Authors:
Nancy L. Pappas; Terese E. Michaud; Russell M. Wolbers; James C. Steward; Thomas A. Fevurly; Timothy J. Samolitis; Bruce A. Shoneboom; Dorraine D. Watts; UNIFORMED SERVICES UNIV OF THE HEALTH SCIENCES BETHESDA MD
|
| Peripheral intravenous (W) cannulation can be difficult to perform using the traditional landmark or visual/palpation technique in patients with access difficulties such as deep, sclerotic, small, or fragile veins. Ultrasound guidance has shown efficacy in expediting the cannulation of central veins, but there is limited information on its utility in facilitating cannulation in peripheral veins, particularly for patients with difficult access. The purpose of this study was to compare the ... |
|
| Modulation of T Cell Tolerance in a Murine Model for Immunotheraphy of Prostatic Adenocarcinoma |
SEP 2006 |
28 pages |
| Authors:
Arthur A. Hurwitz; TRUE RESEARCH FOUNDATION SAN ANTONIO TX
|
| The goal of this project is to characterize T cell tolerance to prostate tumor antigens and to identify the role of costimulatory receptors in overcoming this tolerance. Identification of these processes will assist in the development of novel therapeutic approaches for treating prostate cancer. We use the TRAMP model a transgenic mouse line that develops primary prostatic tumors due to expression of the SV4O T antigen (TAg) under the transcriptional ... |
|
| Special Operations Forces: Several Human Capital Challenges Must Be Addressed to Meet Expanded Role |
JUL 2006 |
55 pages |
| Authors:
GOVERNMENT ACCOUNTABILITY OFFICE WASHINGTON DC
|
| In 1986, the Congress called for the establishment of a joint service special operations capability under a single command. In April 1987, the Secretary of Defense established the Special Operations Command with the mission to provide trained and combat-ready special operations forces to DOD s geographic combatant commands. Section 167(e) of Title 10, U.S. Code directs that the Commander of the Special Operations Command be responsible for and have the ... |
|
| Rescuing High Avidity T Cells for Prostate Cancer Immunotherapy |
APR 2006 |
67 pages |
| Authors:
Pan Zheng; OHIO STATE UNIV COLUMBUS
|
| This is the final report on the grant Rescuing high avidity T cells for prostate cancer immunotherapy. The purpose of the grant proposal is to rescuing high avidity tumor-antigen specific T cells that can respond effectively to prostate cancer cells and delay the development of prostate cancer in the TRAMP mouse model. We have proposed three specific aims. (1). Identify the cells in thymus that express peripheral tumor antigen to ... |
|
| NSMRL See/Rescue Project Target Detectability Testing, Modeling, and Analysis |
JAN 2006 |
132 pages |
| Authors:
E. Anderson; H. Greenbaum; T. McClay; D. Wilson; COAST GUARD RESEARCH AND DEVELOPMENT CENTER GROTON CT
|
| The Coast Guard (CG) Research and Development Center (RDC), funded by the Naval Submarine Medical Research Laboratory (NSMRL), evaluated the detectability of the See/Rescue (S-R) streamer distress signal device in scenarios relevant to Navy search and rescue operations using data collected during two sea test exercises with the following technical objectives. 1. Determine lateral range curve (LRC) functions and sweep width (W) values for the visual acumen of Naval P-3 ... |
|
| New Orleans Levees and Floodwalls: Hurricane Damage Protection |
06 SEP 2005 |
|
| Authors:
Nicole T. Carter; LIBRARY OF CONGRESS WASHINGTON DC CONGRESSIONAL RESEARCH SERVICE
|
| Hurricane Katrina's storm surge breached floodwalls and levees surrounding New Orleans, causing widespread inundation and significant damage and hampering rescue and recovery efforts. Flooding from precipitation and storm surges flowing over levees was anticipated because of the hurricane s intensity; however, structural failure of the floodwalls and consequent flooding were uncertain. The immediate engineering and the underlying causes of the breaches are the subject of speculation, and likely will be ... |
|
| Structure-Based Design of Molecules to Reactivate Tumor Derived p53 Mutations |
JUN 2005 |
10 pages |
| Authors:
Ronen Marmorstein; PENNSYLVANIA UNIV PHILADELPHIA WISTAR INST
|
| Of the genetic alterations associated with breast cancer, changes in p53 are the most frequent and identified. The overall goal of our studies is to identify small molecule compounds that bind and stabilize the subset of tumor-derived p53 mutants. We anticipate that the identification of such compounds will serve as a scaffold for the preparation of small molecule drugs for the treatment of p53-mediated breast cancer. Towards our goal we ... |
|
| Development of Metrics to Evaluate Effectiveness of Emergency Response Operations |
JUN 2005 |
50 pages |
| Authors:
Donald E. Brown; C. D. Robinson; VIRGINIA UNIV CHARLOTTESVILLE
|
| The overall effectiveness of an emergency response to a large scale disaster is a difficult entity to measure. Every disaster is different and every response is different. In fact, similar events leave totally different results in their aftermath. For example a category two hurricane might inflict much more damage than a category four, depending on the location of impact. Additionally, the emergency response to a flood in rural Mississippi will ... |
|
| Effectiveness of Self-Applied Tourniquets in Human Volunteers |
MAY 2005 |
8 pages |
| Authors:
Thomas J. Walters; Joseph C. Wenke; David S. Kauvar; John G. McManus; John B. Holcomb; David G. Baer; ARMY INST OF SURGICAL RESEARCH FORT SAM HOUSTON TX
|
| Tourniquets are not commonly used in routine extremity trauma, but can be vital for hemorrhage control in austere conditions. Objective. To determine the effectiveness in human volunteers of currently available self applied tourniquets for extremity hemorrhage. Methods. Seven tourniquets were tested on the thigh for elimination of detectable distal pulse by Doppler auscultation at the popliteal artery (experiment I, n= 18 subjects). The tourniquets that were effective in >80% of ... |
|
| Structural Basis for the Pharmacological Rescue of Mutant p53 with Small Molecule Compounds |
APR 2005 |
13 pages |
| Authors:
William C. Ho; PENNSYLVANIA UNIV PHILADELPHIA WISTAR INST
|
| The p53 protein is a tumor suppressor crucial to maintaining genomic integrity. In the event of DNA damage, p53 is responsible for transcribing genes leading to cell death. A class of mutations which occur in the core domain (102-292) leads to thermodynamic destabilization and inability to bind its cognate DNA sequence. Small molecules which bind to and stabilize mutant p53 core domain have potential to be therapeutically useful. Two potential ... |
|
| Rescuing High Avidity T Cells for Prostate Cancer Immunotherapy |
APR 2005 |
66 pages |
| Authors:
Pan Zheng; OHIO STATE UNIV RESEARCH FOUNDATION COLUMBUS
|
| This is the second annual report on the grant "Rescuing high avidity T cells for prostate cancer immunotherapy". The purpose of the grant proposal is to rescuing high avidity tumor-antigen specific T cells that can respond effectively to prostate cancer cells and delay the delay the development of prostate cancer in the TRAMP mouse model. The innovative idea is based on the hypothesis that blockade of the T cell costimulatory ... |
|
| Examining the Role of Mah2 and Mrell in Telomere Rescue |
APR 2005 |
16 pages |
| Authors:
Damon Meyer; CITY OF HOPE BECKMAN RESEARCH INST DUARTE CA
|
| Interestingly, about 155 of human cancers have an inactive telomerase gene, leading to the discovery of telomerase-independent mechanisms for regaining telomeric sequences by homologous recombination referred to as alternative lengthening of telomeres(ALT). In S. cerevisiae, there are two ALT pathways controlled by Rad51 and Mre11/Rad50/Xrs2(MRX). The ALT pathway used in humans generates telomeres that resemble the MRX-dependent survivors found in yeast. Recent evidence suggests that the mismatch repair pathway, which ... |
|
| An Augmented Virtuality Display for Improving UAV Usability |
2005 |
3 pages |
| Authors:
Nathan Rackliffe; BRIGHAM YOUNG UNIV PROVO UT
|
| Unmanned Air Vehicles (UAVs) promise to change the way we think about aircraft and airspace and they are being used in many different environments; everything from entertainment to search and rescue operations. One thing common amongst the different UAV platforms is that all use very difficult user interfaces. These interfaces have been designed by engineers and roboticists who do not have training in incorporating the needs of end users. This ... |
|
| Sadr City: The Armor Pure Assault in Urban Terrain |
01-Dec-2004 |
8 pages |
| Authors:
John C Moore; DEFENSE LANGUAGE INST MONTEREY CA FOREIGN LANGUAGE CENTER
|
| Baghdad, Kut, and An Najaf were scenes of concerted attacks by the Mahdi army throughout Iraq on 4 April 2004. On that afternoon, elements of the Mahdi army engaged multiple elements of 2d Battalion, 5th Cavalry Regiment (2-5 CAV), 1st Cavalry Division, nearly simultaneously throughout Sadr City in northern Baghdad. Twenty soldiers from Comanche Red Platoon, 2-5 CAV, had become isolated in the northern central portion of Sadr City, and ... |
|
| Examination of Chesapeake Bay Observing System for Local Environmental Data for Coast Guard Operations |
DEC 2004 |
26 pages |
| Authors:
John Brubaker; Carl Friedrichs; Courtney Harris; Jian Shen; Harry Wang; COAST GUARD GROTON CT MARINE FIRE AND SAFETY RESEARCH DIV
|
| The effective conduct of many of the U.S. Coast Guard's (USCG) missions is strongly influenced by the availability of accurate information on local environmental conditions. As an example, in search and rescue (SAR) operations, pollutant/hazardous product spill response, as well as interdiction of Law Enforcement (LE) targets (migrants, contraband), planning and execution depend on knowledge of water current velocity at the location of the incident, and on forecasts over time-scales ... |
|
| Modulation of T Cell Tolerance in a Murine Model for Immunotherapy of Prostatic Adenocarcinoma |
SEP 2004 |
9 pages |
| Authors:
Arthur A. Hurwitz; STATE UNIV OF NEW YORK UPSTATE MEDICAL CENTER SYRACUSE
|
| The goal of this project is to characterize T cell tolerance to prostate tumor antigens and identify the role of costimulatory receptors in overcoming this tolerance. Identification of these processes will assist in the development of novel therapeutic approaches for treating prostate cancer. We use the TRAMP model, a transgenic mouse line that develops primary prostatic tumors due to expression of the SV4O T antigen (TAg) under the transcriptional control ... |
|
| Conceptual Study of LSTAT Integration to Robotics and Other Advanced Medical Technologies |
31 JUL 2004 |
45 pages |
| Authors:
Jim Osborn; Miltra Rocca; CARNEGIE-MELLON UNIV PITTSBURGH PA
|
| Battlefield medicine is moving toward adoption of several new technologies to both improve the quality of care and protect healthcare providers. One example of this trend is use of the Life Support for Trauma and Transport (LSTAT) patient transport litter in combat conditions. LSTATs are sustaining lives on land, in the air and at sea from Alaska to Iraq. LSTAT was recently introduced into the nation's largest trauma center, Los ... |
|
| Rescuing High Avidity T Cells for Prostate Cancer Immunotherapy |
APR 2004 |
82 pages |
| Authors:
Pan Zheng; OHIO STATE UNIV COLUMBUS
|
| This is the first annual report on the grant Rescuing high avidity T cells for prostate cancer immunotherapy". The purpose of the grant proposal is to rescue high avidity tumor-antigen specific T cells that can respond effectively to prostate cancer cells and delay the development of prostate cancer in the TRAMP mouse model. The innovative idea is based on the hypothesis that blockade of the T cell costimulatory pathway in ... |
|
| Structural Basis for the Pharmacological Rescue of Mutant p53 With Small Molecule Compounds |
APR 2004 |
11 pages |
| Authors:
William C. Ho; PENNSYLVANIA UNIV PHILADELPHIA WISTAR INST
|
| The p53 protein is a tumor suppressor crucial to maintaining genomic integrity. In the event of DNA damage, p53 is responsible for transcribing genes leading to cell death. A class of mutations which occur in the core domain (102- 292) leads to thermodynamic destabilization and inability to bind its cognate DNA sequence. Small molecules which bind to and stabilize mutant p53 core domain have potential to be therapeutically useful. Two ... |
|
| Fin Stabilizers As Maneuver Control Surfaces |
DEC 2003 |
131 pages |
| Authors:
Martin G. Sarch; NAVAL POSTGRADUATE SCHOOL MONTEREY CA
|
| Roll angle is often a limiting factor during high-speed turns and repetitive turning maneuvers. Navy and Coast Guard surface ships are designed for high-speed operation. Sharper turns at higher speeds and repetitive high- speed turns can increase ship survivability by helping these vessels avoid incoming threats. This is particularly true if the amount and direction of roll during the turn is controlled since the ship's susceptibility to radar and other ... |
|
| Hand-Held Ultrasonic Through-the-Wall Monitoring of Stationary and Moving People |
NOV 2003 |
39 pages |
| Authors:
Norbert Wild; JAYCOR SAN DIEGO CA
|
| A prototype system for monitoring respiration and movement through metallic and non-metallic walls has been developed and demonstrated. The man- portable sensor uses high energy ultrasonic pulses and ultra low noise amplification of the return pulse echoes to detect the breathing or motion of individuals in an enclosed space. A real-time video display on the hand-held transducer assembly provides the user with a measure of the location of the detected ... |
|
| Physiological Evaluation of First Responder Mask |
SEP 2003 |
42 pages |
| Authors:
Ronald A. Weiss; Judith Pasternak-Silva; ARMY RESEARCH LAB ABERDEEN PROVING GROUND MD
|
| The First Responder Mask (FIRM) was developed for domestic preparedness/counterterrorism personnel (e.g., firefighters, police, medical support, search and rescue, security, investigators) to provide at least 12 hr of continuous protection against chemical/biological exposure when a terrorist incident or chemical emergency required their participation. It is a powered air- purifying respirator with adjustable hood, nosecup, and one-size-fits-all neck dam configuration. This physiological evaluation of the FIRM tested its suitability for human ... |
|
| Rescue of Black Sea Hydrological Data for Regional Classification and Studies of Seasonal and Interannual Variability |
Sep-2003 |
5 pages |
| Authors:
A M Suvorov; D R Palmer; A K Khaliulin; E A Godin; V N Belokopytov; A V Ingerov; NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION MIAMI FL ATLANTIC OCEANOGRAPHIC AND METEOROLOGICAL LABS
|
| In the framework of the Project Rescue of Black Sea Hydrological Data collected from more than 100,000 Black Sea oceanographic stations from all sources and created a CD-ROM digital atlas Physical Oceanography of the Black Sea based on all available, historical hydrological data. For the providing data access and visualization the database management system was developed and included in CD-ROM. |
|
| Modulation of T Cell Tolerance in a Murine Model for Immunotherapy of Prostatic Adenocarcinoma |
SEP 2003 |
9 pages |
| Authors:
Authur A. Hurwitz; STATE UNIV OF NEW YORK UPSTATE MEDICAL CENTER SYRACUSE
|
| The goal of this project is to characterize T cell tolerance to prostate tumor antigens and identify the role of costimulatory receptors in overcoming this tolerance. Identification of these processes will assist in the development of novel therapeutic approaches for treating prostate cancer. We use the TRAMP model, a transgenic mouse line that develops primary prostatic tumors due to expression of the SV4O T antigen (Tag) under the transcriptional control ... |
|
| Evolution of a Performance Metric for Urban Search and Rescue Robots (2003) |
Sep-2003 |
11 pages |
| Authors:
Elena Messina; Adam Jacoff; Brian Weiss; NATIONAL INST OF STANDARDS AND TECHNOLOGY GAITHERSBURG MD
|
| This paper discusses the advancement and proliferation of the Reference Test Arenas for Urban Search and Rescue Robots as representative search and rescue environments, which allow objective performance evaluation of mobile robot capabilities. These arenas have hosted annual rescue robot competitions sponsored by the American Association for Artificial Intelligence since 2000 and the RoboCupRescue Robot League since 2001. The rules of these competitions have evolved each year to encourage robots ... |
|
| Antiangiogenic Gene Therapy for Breast Cancer Using Targeted Recombinant Adenovirus |
AUG 2003 |
20 pages |
| Authors:
Savio L. Woo; HEALTH RESEARCH INC BUFFALO NY
|
| We tested the expression of NC2 in HeLa cells and generated an El- expression HeLa cell line for the rescue for NG2 targeted adenovirus. Three attempts at virus rescue using NG2 targeted plasmid failed to yield targeted adenovirus. This was not due to a problem with the rescue procedure as we were able to rescue an identical virus without targeting function. We later confirmed by synthesized fluorescence labeled NG2 binding ... |
|
| Recycling of HER/ErbB Receptor: Rescue from Apoptosis and Targets for Immunotherapy |
JUN 2003 |
91 pages |
| Authors:
Yosef Yarden; WEIZMANN INST OF SCIENCE REHOVOT (ISRAEL)
|
| Signals to multiply, migrate and outgrow blood vessels are mediated by growth factors of the EGF/neuregulin family. Concentrating on the EGF- receptor, our first task was to resolve mechanisms that normally restrain signalin. These efforts have led to the realization that activated growth factor receptors are modified by mono-ubiquitins rather than by poly-ubicuitylation. Receptor ubiquitylation is mediated by the c-Cbl E3 ligase, and we identified a Cbl-binding protein, called Grb2, ... |
|
| DNA Base Excision Repair (BER) and Cancer Gene Therapy: Use of the Human N-mythlpurien DNA Glycosylase (MPG) to Sensitize Breast Cancer Cells to Low Dose Chemotherapy |
JUN 2003 |
5 pages |
| Authors:
Tia Harvey; Mark R. Kelly; INDIANA UNIV INDIANAPOLIS
|
| The DNA Base Excision Repair (PER) pathway is responsible for the repair of alkylation and oxidative DNA damage resulting in protection against the deleterious effects of endogenous and exogenous agents encountered on a daily basis. The first enzyme in the human DNA PER pathway, N-methylpurine DNA glycosylase (MPG), is the focus of this proposal. This enzyme is responsible for the removal of damaged bases from the DNA resulting in an ... |
|
| Homeland Security and the Coast Guard: Postured for Technology Improvements |
JUN 2003 |
46 pages |
| Authors:
Arthur C. Walsh; AIR WAR COLL MAXWELL AFB AL
|
| The Coast Guard was effectively positioned to accomplish its missions and functions before the September 2001 terrorist attacks. The terrorist attacks reshaped the United States national security strategy, and this caused the Coast Guard to reprioritize its mission requirements elevating Homeland Security to be on par with the Coast Guard's number one priority, search and rescue operations. To effectively carry out the Homeland Security mission, the Coast Guard must leverage ... |
|
| Structural Basis for the Pharmacological Rescue of Mutant p53 With Small Molecule Compounds |
APR 2003 |
13 pages |
| Authors:
William C. Ho; PENNSYLVANIA UNIV PHILADELPHIA WISTAR INST
|
| The p53 protein is a tumor suppressor crucial to maintaining genomic integrity. In the event of DNA (damage, p53 is responsible for transcribing genes leading to cell death. A class of mutations which occur in the core domain (102-292) leads to thermodynamic destabilization and inability to bind its cognate DNA sequence. Small molecules which bind to and stabilize mutant p53 core domain have potential to be therapeutically useful. A class ... |
|
| Applicability Assessment for Maritime Operations Simulation (MarOpsSim) - Phase II |
FEB 2003 |
28 pages |
| Authors:
Arnold H. Buss; NAVAL POSTGRADUATE SCHOOL MONTEREY CA DEPT OF OPERATIONS RESEARCH
|
| The Maritime Operations Simulation (MarOpsSim) is a modern discrete event simulation being used by the U.S. Coast Guard. MarOpsSim was originally developed by the U.S. Coast Guard Research & Development Center to examine elements of the Search & Rescue and Law Enforcement missions. MarOpsSim is now being extended to encompass all 14 Deepwater missions to support the Deepwater Acquisition. This document reports the results of the Core Verification and Validation ... |
|
Reports by Keyword(s)
RESCUES
