| Improved Logistics for Chemical and Biologics Decontamination for Deployed Military |
Jul 2012 |
58 pages |
| Authors:
Garry J Edgington; Andreas Mylonakis; CELLULAR BIOENGINEERING INC HONOLULU HI
|
 | The primary objective of this contract is to impart CWA neutralization capability into hydrogels with proven efficacy in the physical decontamination of radiological, TICs, TIMs and other contaminants, to achieve efficient decontamination of CWAs that have absorbed into sorptive substrates, via physical removal, neutralization or both. A further objective is to develop strategies to impart bactericidal and sporicidal capability into the systems developed with the ultimate objective being the development ... |
|
| Tritium |
Nov 2011 |
40 pages |
| Authors:
D McMorrow; MITRE CORP MCLEAN VA
|
| Tritium breeding is an essential component of potential future GWE sources of electrical energy based on nuclear fusion. Such reactors require kg quantities of tritium per year of operation which must be bred as part of the overall reactor cycle. Traditionally, tritium is assumed to be bred from neutrons involved in fusion energy-production processes of the particular type of reactor using a lithium (Li) blanket or related alloys such as ... |
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| Ionizing Radiation in Earth's Atmosphere and in Space Near Earth |
MAY 2011 |
32 pages |
| Authors:
Wallace Friedberg; Kyle Copeland; FEDERAL AVIATION ADMINISTRATION OKLAHOMA CITY OK CIVIL AEROSPACE MEDICAL INST
|
| The Civil Aerospace Medical Institute of the FAA is charged with identifying health hazards in air travel and in commercial human space travel. This report addresses one of these hazards - ionizing radiation. Ionizing radiation is a subatomic particle of matter or packet of energy (photon) with sufficient energy to eject an orbital electron from an atom. Charged subatomic particles from exploding stars (supernovae) are a constant source of ionizing ... |
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| Radioactivity, Detection, Indication and Computation (RADIAC) Correlation Factor Testing |
15 APR 2011 |
23 pages |
| Authors:
ARMY WHITE SANDS TEST CENTER WHITE SANDS MISSILE RANGE NEW MEXICO SURVIVABILITY VULNERABILITY AND ASSESSMENT DIRECTORATE (SVAD)
|
| This TOP describes the techniques, procedures, and general outline required to determine the RADIAC Correlation Factor to estimate the external environment from an internal measurement. Test/Analysis preparation, execution, and documentation are covered in this TOP. |
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| Optimizing and Evaluating an Integrated SPECT-CmT System Dedicated to Improved 3-D Breast Cancer Imaging |
MAY 2010 |
31 pages |
| Authors:
Dominic Crotty; DUKE UNIV DURHAM NC
|
| The overall objective of this research is to optimize the development of a combined dual-modality single photon emission computed tomography (SPECT) and x-ray computed mammotomography (CmT) system for the earlier detection and staging of breast cancer, improving surgical biopsy guidance, and the monitoring of patient therapy response. It is believed that co-registered acquisition of emission (nuclear) and transmission (x-ray) data using both 3D imaging modalities in a common field of ... |
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| Optimizing and Evaluating an Integrated SPECT-CmT System Dedicated to Improved 3-D Breast Cancer Imaging |
May-2009 |
64 pages |
| Authors:
Dominic J Crotty; DUKE UNIV DURHAM NC
|
| The overall objective of this research is to optimize the development of a combined dual-modality single photon emission computed tomography (SPECT) and x-ray computed mammotomography (CmT) system for the earlier detection and staging of breast cancer, improving surgical biopsy guidance, and the monitoring of patient therapy response. Co-registered acquisition of emission (nuclear) and transmission (x-ray) data using both 3D imaging modalities in a common field of view may aid to ... |
|
| Identification and Development of Biological Markers of Human Exposure to the Insecticide Permethrin |
Apr 2008 |
147 pages |
| Authors:
Bruce D Hammock; Shirley J Gee; CALIFORNIA UNIV DAVIS
|
| Impregnating uniforms with the insecticide permethrin may result in dermal exposure to military personnel. We identified key metabolite(s) from a low dose exposure using accelerator mass spectrometry and developed immunoassays for them for future monitoring. Metabolite stan-dards were synthesized and an HPLC system to separate individual metabolites in urine was developed. Six subjects were exposed dermally for 8h. Blood, saliva and urine samples were taken for 7d. Absorption/elimination rates and ... |
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| Development and Optimization of a Dedicated, Hybrid Dual-Modality SPECT-CmT System for Improved Breast Lesion Diagnosis |
JAN 2008 |
41 pages |
| Authors:
Priti Madhav; DUKE UNIV DURHAM NC
|
| The overall objective of this project is to implement a dual-modality single photon emission computed tomography (SPECT) and x-ray computed mammotomography (CmT) system for the detection and staging of breast cancer monitoring of treatment therapies and improving surgical biopsy guidance. The sequential acquisition with emission (nuclear) and transmission (x-ray) 3D imaging systems can aid in localizing the radioactive uptake of a tumor from the emission image by using the anatomical ... |
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| Genetically Targeted Radiotherapy Utilizing the Human Sodium Iodide Symporter in Human Breast Carcinoma Cells |
JUL 2007 |
10 pages |
| Authors:
Kimberly Krager; IOWA UNIV IOWA CITY
|
| The purpose of this proposal was to elaborate on the viability of NIS-mediated genetically targeted radiotherapy as a possible novel therapeutic intervention in human breast carcinoma. Problems encountered with SK- Pr-3 forced other cell limes to be utilized for tumor growth and imaging. A stable NIS expressing clone was derived from SK-Pr-3 cell lime. The ability of the clone to accumulate radioactivity was lost after several passages, which may be ... |
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| Analysis of Coolant Options for Advanced Metal Cooled Nuclear Reactors |
DEC 2006 |
89 pages |
| Authors:
Levent Can; NAVAL POSTGRADUATE SCHOOL MONTEREY CA
|
| It is well known that any neutron-producing device generates induced radioactivity as a by-product of its operation. In the case of nuclear reactors, the induced radioactivity includes fission and activation products. The overall focus of this study is the build up of induced radioactivity in the coolant of metal cooled reactors as well as the evaluation of other physical and chemical properties of such coolants. The objectives of the thesis ... |
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| Intra-Operative Dosimetry in Prostate Brachytherapy |
NOV 2006 |
92 pages |
| Authors:
Ameet Jain; JOHNS HOPKINS UNIV BALTIMORE MD
|
| Favorable outcome in prostate brachytherapy critically depends on the accurate placement of radioactive sources in their planned locations. Unfortunately, there is variety of mechanical factors that cause the seeds to divert from their planned locations. While this problem has been known to brachytherapists, current technology does not allow for reliable localization of the implanted sources, thereby prohibiting the prediction and modification of seed distribution intra-operatively. The Research Objective of the ... |
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| Effect of Solventless Bore Cleaning Device (SBCD) on Surface Finish and Contamination Transport in the M256 Gun Barrel |
SEP 2006 |
14 pages |
| Authors:
Mark Bundy; James Garner; Gerald Garcia; Robert Baylor; Terry Marrs; Julius Pitts; Bob Vanina; ARMY RESEARCH LAB ABERDEEN PROVING GROUND MD WEAPONS AND MATERIALS RESEARCH DIRECTORATE
|
| A new solventless bore cleaning technique, marketed by GI Industries, is currently under review by the U.S. Army Research Laboratory, Benet Laboratory, and the Aberdeen Test Center. Previous studies have shown that this new cleaning system is efficient at removing propellant residue/glaze without producing any measurable bore wear. This report speaks to both the subtle question of whether or not this new method of cleaning roughens the surface finish; but ... |
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| PET and Hormone Receptor Ligands in Breast Cancer |
MAY 2006 |
5 pages |
| Authors:
Mary Gemignani; MEMORIAL SLOAN-KETTERING CANCER CENTER NEW YORK
|
| F-18 labeled estradiol has been found to be useful in the evaluation of estrogen receptor status in patients with breast cancer using PET. To investigate this further, this project's objectives are: To evaluate the use of estrogen-like ligands labeled with positron emitters in preoperatively determining the ER status of breast cancer using PET. Correlate the ER positivity seen on PET imaging with ER positivity found on pathologic analysis of the ... |
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| Genetically Targeted Radiotherapy Utilizing the Human Sodium Iodide Symporter in Human Breast Carcinoma Cells |
APR 2006 |
11 pages |
| Authors:
Kimberly Krager; Frederick E. Domann; IOWA UNIV IOWA CITY
|
| The purpose of this proposal was to examine the efficiency of NIS mediated genetically targeted radiotherapy as a possible non-invasive therapeutic treatment in human breast carcinoma. SK-Br-3 cells were transfected with hNlS plasmid to develop stable NIS expressing cells. Clones were grown and are currently being screen for radioactive accumulation. The stable NIS-expressing cells will then be utilized in determining the level of NIS expression necessary to elicit a bystander ... |
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| Strategies for Treatment of Bone Metastases from Breast Cancer |
OCT 2005 |
45 pages |
| Authors:
Rajagopalan Sridhar; HOWARD UNIV WASHINGTON DC
|
| The major goal of this project is to optimize the strategies for using radioactive strontium for palliation of bone pain due to breast cancer metastases. One approach is to determine ways of selectively increasing strontium uptake at the metastatic site. Bisphosphonates are useful in the treatment of osteoporosis and bone metastases. Bisphosphonates sequester calcium and strontium. Strontium was non toxic to human breast cancer cells. Bisphosphonates are charged molecules that ... |
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| Strategic for Treatment of Bone Metastases from Breast Cancer |
28 SEP 2005 |
14 pages |
| Authors:
Rajagopalan Sridhar; HOWARD UNIV WASHINGTON DC
|
| The major goal of this project is to optimize the strategies for using radioactive strontium for palliation of bone pain due to breast cancer metastases. One approach is to determine ways of selectively increasing strontium uptake at the metastatic site. Estrogens and a variety of other pharmacological agents can influence cellular uptake of calcium and strontium. Cultures of hormone sensitive and hormone independent breast cancer cells and fetal steoblasts and ... |
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| Biodistribution and Tumor-Targeting Potential of Poly(Ethylene Glycol)-Modified Gelatin Nanoparticles |
13 JUL 2005 |
7 pages |
| Authors:
Goldie Kaul; Mansoor Amiji; NORTHEASTERN UNIV BOSTON MA
|
| In order to develop a safe and effective systemically-administered delivery system for solid tumors, the biodistribution of control gelatin and poly(ethylene-glycol) modified (PEGylated) gelatin nanoparticles was examined in Lewis lung carcinoma (LLC)-hearing female C57BL6 mice. Type B gelatin and PEGylated gelatin nanoparticles were radiolabeled (125I) for the in vivo biodistribution studies after intravenous (i.v.) administration through the tail vein in LLC-bearing mice. At various time intervals, the tumor-bearing mice were ... |
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| Radiochemical and Chemical Constituents in Water from Selected Wells and Springs from the Southern Boundary of the Idaho National Laboratory to the Hagerman Area, Idaho, 2003 |
2005 |
33 pages |
| Authors:
Gordon W. Rattray; Amy J. Wehnke; L. F. Hall; Linford J. Campbell; GEOLOGICAL SURVEY WASHINGTON DC
|
| The U.S. Geological Survey and the Idaho Department of Water Resources, in cooperation with the U.S. Department of Energy, sampled water from 14 sites as part of an ongoing study to monitor the water quality of the eastern Snake River Plain aquifer between the southern boundary of the Idaho National Laboratory (INL) and the Burley-Twin Falls-Hagerman area. The State of Idaho, Department of Environmental Quality, Division of INL Oversight and ... |
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| Radiochemical and Chemical Constituents in Water from Selected Wells and Springs from the Southern Boundary of the Idaho National Laboratory to the Hagerman Area, Idaho, 2003 |
2005 |
33 pages |
| Authors:
Gordon W. Rattray; Amy J. Wehnke; L. F. Hall; Linford J. Campbell; GEOLOGICAL SURVEY RESTON VA
|
| The U.S. Geological Survey and the Idaho Department of Water Resources, in cooperation with the U.S. Department of Energy, sampled water from 14 sites as part of an ongoing study to monitor the water quality of the eastern Snake River Plain aquifer between the southern boundary of the Idaho National Laboratory (INL) and the Burley-Twin Falls-Hagerman area. The State of Idaho, Department of Environmental Quality, Division of INL Oversight and ... |
|
| PET Radiotracers for Imaging the Proliferation Status of Breast Tumors |
DEC 2004 |
75 pages |
| Authors:
Robert H. Mach; WASHINGTON UNIV ST LOUIS MO
|
| The goal of this research project is to develop radiotracers for imaging the proliferative status of breast tumors using the noninvasive imaging technique, Positron Emission Tomography (PET). The strategy taken involves developing radiotracers having a high affinity and selectivity for the sigma (sub 2) receptor, which has been shown to be a useful receptor-based biomarker of proliferation in breast tumor cells growing both in vitro and in vivo. During the ... |
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| Water-Quality Changes During Cycle Tests at Aquifer Storage Recovery (ASR) Systems of South Florida |
JUN 2004 |
53 pages |
| Authors:
June E. Mirecki; ENGINEER RESEARCH AND DEVELOPMENT CENTER VICKSBURG MS ENVIRONMENTAL LAB
|
| Water-quality changes were interpreted from existing cycle test data obtained from 11 treated surface-water Aquifer Storage Recovery (ASR) systems located in South Florida. Six ASR systems are located along the lower east coast (Palm Beach and Broward Counties), and five ASR systems are located in Lee and Collier Counties. These diverse data sets were the basis for interpretations of water-quality changes during ASR cycles in different regions. These data sets ... |
|
| Imaging Primary Prostate Cancer and Bone Metastasis |
APR 2004 |
53 pages |
| Authors:
Xiaoyuan Chen; UNIVERSITY OF SOUTHERN CALIFORNIA LOS ANGELES
|
| The overall objective of the proposed research is to develop positron emitter labeled bombesin analogs with high affinity for the GRP receptor BB2 for microPET imaging of both androgen dependent and androgen independent prostate cancer xenografted mice. Specific Aims: (1) Design, synthesize, and characterize positrori emitting bombesin analogs, labeled with copper-64 or fluorine-I 8; (2) Conduct in vitro studies of copper-64 and fluorine-18 labeled bombesin analogs to evaluate the effect ... |
|
| Preclinical Pharmacodynamic and Pharmacokinetic Studies of Investigational New Drugs |
01 MAR 2004 |
171 pages |
| Authors:
Patricia E. Noker; SOUTHERN RESEARCH INST BIRMINGHAM AL
|
| Under this contract, pharmacokinetic, pharmacodynamic, bioavailability, and metabolism studies were conducted with the anti-malarial agent, artelinic acid. During these investigations, artesunic acid and arteether served as positive control agents. Major findings indicated that the oral bioavailability of artelinic acid in dogs was 67%; artelinic acid was extensively metabolized by dogs following either iv or oral administration; radioactivity derived from 14Cartelinic acid underwent biliary excretion; a "no effect" dose of artelinic ... |
|
| Immobilization of 2,4- and 2,6-Dinitrotoluenes in Soils and Compost |
JAN 2003 |
50 pages |
| Authors:
Judith C. Pennington; Kevin A. Thorn; Charolett A. Hayes; Beth E. Porter; K. R. Kennedy; ENGINEER RESEARCH AND DEVELOPMENT CENTER VICKSBURG MS ENVIRONMENTAL LAB
|
| Covalent bonding of amino transformation products of trinitrotoluene (TNT) to functional groups on humic acid results in immobilized products that are not hydrolyzable, microbially degradable, or leachable. However, the extent to which these reactions occur with dinitrotoluenes (DNTs) was unknown. Since DNTs are considered toxic and many explosives-contaminated sites exhibit DNTs as well as TNT, the fate of DNTs is relevant to remediation and risk assessment. The broad objectives of ... |
|
| Development of an RF Ion Guide for Trapping Energetic Radioactive Nuclear Ions |
24 JUN 2002 |
9 pages |
| Authors:
M. Wada; Y. Ishida; T. Nakamura; N. Oshima; Y. Nakai; SOPHIA UNIV TOKYO (JAPAN) DEPT OF PHYSICS
|
| Although the projectile fragment separator (RIPS) at the RIKEN accelerator facility (RARF) provides wide variety of energetic radioactive beams, it is not adequate for low energy beam experiments such as precision spectroscopy of trapped ions. Aiming for an efficient deceleration and cooling of energetic radioactive ions, the development of an rf ion guide system which comprises a large He gas cell and an rf funnel structure in the cell is ... |
|
| PET Radiotracers for Imaging the Proliferative Status of Breast Tumors |
JUN 2002 |
8 pages |
| Authors:
Robert H. Mach; WAKE FOREST UNIV WINSTON-SALEM NC SCHOOL OF MEDICINE
|
| The goal of this IDEA grant was to prepare a 18F-labeled radiotracer having a high affinity and selectivity for the sigma-2 receptor that can be used for Positron Emission Computed Tomography (PET) imaging studies of breast cancer. Our choice of this receptor system stems from the observation that there is a high density of sigma2 receptors in both murine and human breast cancer cells in vitro. In addition, we have ... |
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| The Use of Tritium Autoradiography to Assess Fatigue Damage in Metals |
FEB 2002 |
|
| Authors:
K. A. Tsoi; A. K. Wong; DEFENCE SCIENCE AND TECHNOLOGY ORGANISATION VICTORIA (AUSTRALIA) AERONAUTICAL AND MARITIME RESEARCH LAB
|
 | This report introduces a technique known as tritium autoradiography which may be useful in the detection of fatigue damage in metallic components. Tritium autoradiography involves the infusion of radioactive hydrogen (tritium) into a fatigue damaged structure. The damaged areas of the structure may act as preferred trapping sites for the tritium and as the tritium decays via the emission of beta particles it can be detected using nuclear emulsion film. ... |
|
| Preclinical and Clinical Evaluation of Novel Agents for Noninvasive Imaging of Prostate Cancer |
FEB 2002 |
134 pages |
| Authors:
Raymond E. Counsell; Milton D. Gross; Richard L. Wahl; MICHIGAN UNIV ANN ARBOR
|
| Imaging procedures play an important role in the current management of patients with prostate cancer. Despite advances in many of these methodologies, improvements are still needed, especially in the area of Nuclear Medicine. The radiodinated phospholipid ether analogs investigated under this grant represent a new class of radiopharmaceutical, which has provided excellent images of prostate tumors in animal models. Two of the newer analogs, namely NM- 404 and NM-412, were ... |
|
| MAGNETIC SENSORS AND THEIR UNIQUE APPLICATIONS, |
FEB 2002 |
|
| Authors:
J. Lenz; HONEYWELL INC MINNEAPOLIS MN
|
| (U) THIS PAPER IS A REPRESENTATION OF THE SUBJECT THROUGH THE SLIDES PRESENTED AT THE MEETING. THE SLIDES ARE FIGURES SHOWING PICTORIALLY APPLICATIONS CONCERNING POSITION SENSING, MAGNETIC ANOMALY DETECTION, COMPASSING, AND CURRENT SENSING. |
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| A BIOLOGICAL MODEL FOR DIRECTIONAL SENSING OF SEISMIC VIBRATION, |
FEB 2002 |
|
| Authors:
R. N. Miles; R. B. COCROFT; STATE UNIV OF NEW YORK AT BINGHAMTON DEPT OF MECHANICAL AND INDUSTRIAL ENGINEERING
|
| (U) THIS PAPER DISCUSSES A STUDY PROVIDING AN INSECT MODEL OF VIBRATION LOCALIZATION THAT PROVIDES AN APPROACH TO DIRECTIONAL VIBRATION SENSING OVER VERY SMALL SPATIAL SCALES. THE TREEHOPPER, UMBONIA CRASSICORNIS, COMMUNICATES USING VIBRATIONAL SIGNALS TRANSMITTED ALONG PLANT STEMS IN THE FORM OF BENDING WAVES. THE INSECT DETECTS SUBSTRATE VIBRATIONS USING SENSORS IN THE LEGS. A SIMULATOR WAS CONSTRUCTED THAT MIMICS SURFACE MOTION OF PROPAGATING BENDING WAVES TO EXPLORE DIRECTIONAL SENSING ... |
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| Evaluation of Radiolabeled Tumor Vessel Targeting Peptides as Novel Agents for the Staging and Therapy of Human Prostate Cancer |
FEB 2002 |
11 pages |
| Authors:
Bruce R. Line; Antonio Passaniti; Carol Lambert; Ron Mease; MARYLAND UNIV BALTIMORE
|
| The purpose of this study is to develop a new imaging agent to detect prostate cancer. This will be accomplished by using radiolabeled peptides that bind specifically to receptors on tumor blood vessels. The approach will produce a picture of the tumor for determining the spread of prostate cancer or the agent can be modified to help destroy the tumor. It is known that the blood vessels that nourish prostate ... |
|
| NUCLEAR REGULATION: Progress Made in Emergency Preparedness at Indian Point 2, but Additional Improvements Needed |
JUL 2001 |
64 pages |
| Authors:
GENERAL ACCOUNTING OFFICE WASHINGTON DC
|
| In February 2000, Consolidated Edison Company shut down the Indian Point 2 commercial nuclear power plant in New York State because a tube had ruptured in a steam generator, raising the possibility that radioactively contaminated water could leak into the environment. 1 In this particular instance, the total amount of radioactivity released posed no threat: It was about one thousandth of the dose an individual receives from a chest X-ray. ... |
|
| Seismic Signature and Methodology Standard |
APR 2001 |
32 pages |
| Authors:
RANGE COMMANDERS COUNCIL WHITE SANDS MISSILE RANGE NM SIGNATURE MEASUREMENT STANDARDS GROUP
|
| Seismic technology is a branch of the field of geophysics, the study of the earth using physical measurements at the surface. The geophysics, field employs many prospecting methods, including the following: seismic refraction; seismic reflection; gravitation; and magnetic, electrical, and radioactive anomalies. |
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| Permanent Implantation Brachytherapy for Prostate Cancer Using a Mixture of Radionuclides with Different Half Lives |
MAR 2001 |
15 pages |
| Authors:
Ravinder Nath; YALE UNIV NEW HAVEN CT SCHOOL OF MEDICINE
|
| The project objective is to test whether the effectiveness of brachytherapy for prostate cancer can be improved by using a combination of short and long half life radionuclides simultaneously. Key research accomplishments in the past year are: (i) a theoretical model based on incomplete repair of radiation damage at low dose rates was developed for addressing the questions raised in the project; (ii) cell survival curves for both (125)I and ... |
|
| Preclinical and Clinical Evaluation of Novel Agents for Noninvasive Imaging of Prostate Cancer |
FEB 2001 |
57 pages |
| Authors:
Raymond Counsell; Milton Gross; MICHIGAN UNIV ANN ARBOR
|
| Imaging procedures play an important role in the current management of patients with prostate cancer. Despite advances in many of these methodologies, improvements are still needed, especially in the area of Nuclear Medicine. The radioiodinated phospholipid ether analogs being investigated under this grant represent a new class of radiopharmaceutical, which has provided excellent images of prostate tumors in animal models. Two of the newer analogs, namely NM-404 and NM-412, were ... |
|
| Probing the Paclitaxel-microtubule Binding Site and Interactions: Design, Synthesis and Evaluation of New Photoaffinity Taxoids |
JUL 2000 |
33 pages |
| Authors:
Jared Spletstoser; Gunda I. Georg; KANSAS UNIV CENTER FOR RESEARCH INC LAWRENCE
|
| Paclitaxel (taxol), a structurally complex diterpenoid1 has been developed as a potent drug.against a variety of cancers including breast cancer, ovarian cancer, Kaposi's sarcoma and advanced lung cancer. It possesses unique mechanism of action by binding microtubule and disrupting the microtubule network during cell division. However, the exact paclitaxel binding site on tubulin still remains unclear at the molecular level, and it is essential to understand the interactions of paclitaxel ... |
|
| The Design and Emulation of a Multiple-Camera SPECT Breast Imager |
JUL 2000 |
41 pages |
| Authors:
John Sain; H. Barrett; ARIZONA UNIV TUCSON
|
| The purpose of this study has been to design and emulate a multiple- camera dedicated SPECT breast imager. The scope of this study involved characterizing radioactivity within a human breast, building breast phantoms for imaging, modeling mean detector responses, optimizing the system geometry, collecting planar projection data, measuring detector performance for the task of detecting signals in random backgrounds, emulating the system point response function, and generating three-dimensional reconstructions of ... |
|
| Carcinogenesis of Depleted Uranium Fragments |
JUN 2000 |
67 pages |
| Authors:
Fletcher F. Hahn; DEPARTMENT OF ENERGY ALBUQUERQUE NM ALBUQUERQUE OPERATIONS OFFICE
|
| This study determined the carcinogenicity of depleted uranium DU(Ti) fragments in muscles of rats. Implants of DU(Ti) were compared to implants of tantalum (Ta), as a foreign-body control, and to injections of radioactive Thorotrast(R), a colloid of thorium dioxide, as a radioactive control. The test metals, in four squares (2.5 x 2.5 x 1.5 mm or 5.0 x 5.0 x 1.5 mm) or pellets (2.0 x 1.0 mm diam.) were ... |
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| Preclinical Pharmacodynamic and Pharmacokinetic Studies of Investigated New Drugs |
DEC 1999 |
|
| Authors:
Patricia E. Noker; SOUTHERN RESEARCH INST BIRMINGHAM AL
|
| During this contract, pharmacokinetic, pharmacodynamic, bioavailability, and metabolism studies were conducted on the following compounds under development by the U.S. Army Medical Research Acquisition Activity: the anti-cyanotic agents, WR 242511 and PAHP; the nerve agent antidote, 111-6; the anti-malarial agents, WR 238605, WR 243251 and isomers, WR 250547 and WR 250548, artelinic acid and N-desbutylhalofantrine. Major findings indicated that a metabolite of WR ... |
|
| Explosives Conjugation Products in Remediation Matrices |
DEC 1999 |
52 pages |
| Authors:
J. C. Pennington; K. A. Thorn; L. S. Inouye; V. A. McFarland; A. S. Jarvis; DEPUTY DIRECTOR OF DEFENSE RESEARCH ANDENGINEERING ARLINGTON VA STRATEGIC ENVIRONMENTAL RESEARCH AND DEVELOPMENT
|
| Immobilization of 2,4,6-trinitrotoluene (TNT) in soils and in compost has been widely documented. Dramatic reductions in solvent-extractable TNT have been observed, while complete recoveries of radioactivity from carbon-14 labeled TNT indicated that all of the products of TNT remained in the matrix in some form. The objectives of these studies were to determine the nature and mechanism of immobilization and the long-term stability, biodegradability, and toxicity of the ... |
|
| Preclinical and Clinical Evaluation of Novel Agents for Noninvasive Imaging of Prostate Cancer |
AUG 1999 |
16 pages |
| Authors:
Richard L. Wahl; MICHIGAN UNIV ANN ARBOR
|
| It is often impossible to optimally plan therapy for prostate cancer as current imaging is unreliable in determining if the cancer has spread beyond the prostate. Similarly, when prostate cancer recurs, as evidenced by a rising serum PSA level, non-invasively determining the precise location of the recurrence is often impossible. We have developed new radioactive compounds, NM404 and NM412, which are radioiodinated phospholipid ether analogs and have shown that they ... |
|
| The Design and Emulation of a Multiple-Camera SPECT Breast Imager |
JUN 1999 |
10 pages |
| Authors:
John D. Sain; ARIZONA UNIV TUCSON
|
| This report summarizes the work completed in Year 2 of this grant. The work included continuing to optimize the geometry of the system configuration, emulating the system point spread function, developing an algorithm to generate three-dimensional reconstructions, collecting projection data for the small and large cameras, and generating three-dimensional reconstructions of the radiotracer distribution within the breast phantom The work was significantly hampered ... |
|
| Highly Pervious Liquid Metal Target Systems for Radioactive Ion Beam Generation |
JUN 1999 |
90 pages |
| Authors:
Breckenridge S. Morgan; NAVAL POSTGRADUATE SCHOOL MONTEREY CA
|
| Radioactive ion beams (RIBs) of (69)As are currently needed for fundamental nuclear physics research and can be produced abundantly by proton bombardment of a liquid Ge target. In this thesis, we develop a series of highly pervious liquid target designs with mean diffusion paths several orders of magnitude less than traditional, pool-type, liquid targets. Experiments have been performed to identify materials (substrates) capable of suspending, through wetting, very thin layers ... |
|
| Diagnosis and Dosimetry of Exposure to Sulfur Mustard: Development of Standard Operating Procedures; Further Exploratory Research on Protein Adducts |
JAN 1999 |
|
| Authors:
Hendrick P. Benschop; Daan Noort; Govert P. van der Schans; Leo P. A. de Jong; PRINS MAURITS LABORATORIUM TNO RIJSWIJK(NETHERLANDS)
|
| In continuation of previous grants, a tentative standard operating procedure has been developed for two methods for retrospective detection of exposure to sulfur mustard: an immunoslotbiot assay and/or ELISA for DNA adducts in blood and skin and the modified Edman procedure for determination of adducts to the N-terminal valine in hemoglobin. Both procedures could substantially be shortened, while their sensitivities were improved. Furthermore, exploratory research is performed aiming at the ... |
|
| Reducing Army EM Protection Costs, Excavation of Radioactive Soils, Personnel Risk and Casualty Criteria Document (PRCC), International Agreements |
1999 |
|
| Authors:
ARMY NUCLEAR AND CHEMICAL AGENCY SPRINGFIELD VA
|
| This NBC Report, military publication, is concerned with NBC related missions. It includes all combat and materiel developers and all units with chemical and nuclear surety programs. |
|
| Carcinogenesis of Depleted Uranium |
OCT 1998 |
28 pages |
| Authors:
Fletcher F. Hahn; LOVELACE BIOMEDICAL AND ENVIRONMENTAL RESEARCH INST ALBUQUERQUE NM
|
| Depleted uranium (DU)-containing shrapnel was found in the wounds of several Gulf War veterans. DU may be more hazardous than other shrapnel because of its radioactivity and known toxicity to the kidney. Predictions of risk are necessary to guide the medical management of soldiers with DU-bearing wounds both now and in the future. We are determining the carcinogenicity of radioactive DU fragments in tissues relative to nonradioactive foreign-body fragments and ... |
|
| Allegations of Environmental Contamination and Hazards Affecting the Inupiat Community of the Arctic Slope, Alaska. Evaluation Report |
28 SEP 1998 |
54 pages |
| Authors:
INSPECTOR GENERAL DEPT OF DEFENSE ARLINGTON VA
|
| This evaluation was requested by the Deputy Under Secretary of Defense (Environmental Security). The request was based on a telephone conversation between the Native American project manager, Naval Surface Warfare Center, Indian Head Division, Indian Head, MD and the Inupiat community representative. The Inupiat community of the Arctic Slope, Alaska alleged that the past activities of the Department of Defense and other Federal agencies exposed the Inupiat community to environmental ... |
|
| Population Health in Regions Adjacent to the Semipalatinsk Nuclear Test Site |
SEP 1998 |
60 pages |
| Authors:
ARMED FORCES RADIOBIOLOGY RESEARCH INSTBETHESDA MD
|
| This research covers archived results of complex medical examinations done in the 1950s and 1960s by the Ministry of Health (Minzdrav) of the Union of Soviet Socialist Republics (USSR). Inhabitants of several Kazakhstan regions were contaminated in different years by radioactive fallout from atmospheric nuclear tests at the Semipalatinsk test site. The demand for analyzing the archives came about because the health status of the population had deteriorated, and the ... |
|
| Development of a Multimedia Exposure Assessment Model for Evaluating Ecological Risk of Exposure to Military-Related Compounds (MRCs) at Military Sites |
SEP 1998 |
50 pages |
| Authors:
Patrick N. Deliman; Jeffrey A. Gerald; ARMY ENGINEER WATERWAYS EXPERIMENT STATION VICKSBURG MS
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| This report describes several multimedia exposure assessment models and discusses their applicability for use in evaluating ecological risk of exposure to military-related compounds (MRCs). The risk of exposure to MRCs by ecological units is of vital importance because of the unique characteristics of certain military specific compounds. This assessment of risk is valuable for permitting and planning activities as well as for possible cleanup operations of ... |
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| Preclinical Pharmacodynamic and Pharmacokinetic Studies of Investigational New Drngs |
AUG 1998 |
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| Authors:
Patricia Noker; SOUTHERN RESEARCH INST BIRMINGHAM AL
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| During the contract pharmacokinetic, pharmacodynamic, bioavailability and metabolism studies were conducted on the following compounds under development by the U.S. Army Medical Research Acquisition Activity: the anti- cyanotic agents, WR 242511 and PAHP; the nerve agent antidote, HI-6; the anti- malarial agents, WR 238605, WR 243251 and isomers, WR 250547 and WR 250548, artelinic acid and N-desbutylhalofantrine. Major findings indicated that a metabolite of WR ... |
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