| Passive Reactive Berm to Provide Low Maintenance Lead Containment at Active Small Arms Firing Ranges: Field Demonstration |
Aug 2012 |
96 pages |
| Authors:
Michelle Wynter; Steven L Larson; W A Martin; Chris S Griggs; Gregory O'Connor; David Mackie; Catherine C Nestler; ENGINEER RESEARCH AND DEVELOPMENT CENTER VICKSBURG MS ENVIRONMENTAL LAB
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 | Heavy metals are released into the environment as a result of critical military live-fire training. Preventing heavy-metal migration into and contamination of the local environment is crucial because remediating contaminated soils is resource intensive, difficult, and costly. Previous studies have demonstrated that phosphate amendments have been successfully used as a best management practice (BMP) to immobilize metal contaminants. The Passive Reactive Berm (PRBerm) technology incorporates phosphate amendments with ballistic sand ... |
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| Glucose-6-phosphate Reduces Calcium Accumulation in Rat Brain Endoplasmic Reticulum |
Apr 2012 |
9 pages |
| Authors:
Jeffrey T Cole; William S Kean; Harvey B Pollard; Ajay Verma; William D Watson; UNIFORMED SERVICES UNIV OF THE HEALTH SCIENCES BETHESDA MD
|
| Brain cells expend large amounts of energy sequestering calcium (Ca2+), while loss of Ca2+ compartmentalization leads to cell damage or death. Upon cell entry, glucose is converted to glucose-6-phosphate (G6P), a parent substrate to several metabolic major pathways, including glycolysis. In several tissues, G6P alters the ability of the endoplasmic reticulum (ER) to sequester Ca2+. This led to the hypothesis that G6P regulates Ca2+ accumulation by acting as an endogenous ... |
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| Influences On The Oceanic Biogeochemical Cycling Of The Hybrid-Type Metals: Cobalt, Iron, And Manganese |
Feb 2012 |
300 pages |
| Authors:
Abigail E Noble; MASSACHUSETTS INST OF TECH CAMBRIDGE JOINT PROGRAM IN APPLIED OCEAN SCIENCE AND ENGINEERING
|
| Trace metal cycling is one of many processes that influence ocean ecosystem dynamics. Cobalt, iron, and manganese are redox active trace metal micronutrients with oceanic distributions that are influenced by both biological and abiotic sources and sinks. Their open ocean concentrations range from picomolar to nanomolar, and their bioavailabilities can impact primary production. Understanding the biogeochemical cycling of these hybrid-type metals with an emphasis on cobalt was the focus of ... |
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| Innovative In-Situ Remediation of Contaminated Sediments for Simultaneous Control of Contamination and Erosion. Part 1 |
Aug 2011 |
304 pages |
| Authors:
Kenneth Dixon; Danny Reible; Jesse Roberts; Iona Petrisor; SAVANNAH RIVER NATIONAL LAB AIKEN SC
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| Active or reactive capping, is the application of a relatively thin layer of reactive material to the sediment to physically and chemically reduce contaminant mobility and/or bioavailability. This project addressed high priority research needs related to developing/selecting active capping materials and cap designs for contaminant sequestration under a range of aquatic sediment conditions and assessing the ability of innovative amendments to immobilize a variety of organic and inorganic contamination and ... |
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| Innovative In-Situ Remediation of Contaminated Sediments for Simultaneous Control of Contamination and Erosion. Part 1 |
27 Dec 2010 |
304 pages |
| Authors:
Anna S Knox; Michael H Paller; Kenneth L Dixon; Danny D Reible; Jesse Roberts; Ioana G Petrisor; SAVANNAH RIVER NATIONAL LAB AIKEN SC
|
| Active or reactive capping, is the application of a relatively thin layer of reactive material to the sediment to physically and chemically reduce contaminant mobility and/or bioavailability. This project addressed high priority research needs related to developing/selecting active capping materials and cap designs for contaminant sequestration under a range of aquatic sediment conditions and assessing the ability of innovative amendments to immobilize a variety of organic and inorganic contamination and ... |
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| Induction and Acceleration of Mammary Tumors by Activated P13 Kinase |
JUL 2010 |
4 pages |
| Authors:
Erica Nolte; Steven Anderson; COLORADO UNIV HEALTH SCIENCES CENTER AURORA CO
|
| During this time period the necessary retroviral vectors were developed, used to transduce mammary epithelial cells, and these transduced cells were transferred into the cleared fat pad of recipient mice. Although ductal outgrowth occurred in the cleared fat pads indicating that the transplant was successful, the number of GFP positive ducts that grew out was very low. This was surprising given that a high proportion (greater than 80%) of the ... |
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| Making the Best of What You've Got -- Optimizing Military Water Treatment Plant Processes for Cryptosporidium Removal & Regulatory Compliance |
16 Jun 2010 |
19 pages |
| Authors:
Steve Clarke; ARMY PUBLIC HEALTH COMMAND ABERDEEN PROVING GROUND MD
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| Treatability Study Report for In SITU Lead Immobilization Using Phosphate-Based Binders |
MAY 2008 |
195 pages |
| Authors:
R. M. Bricka; Anirudha Marwaha; Gene L. Fabian; MISSISSIPPI STATE UNIV MISSISSIPPI STATE
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| Metal contamination in soil is found on 69 percent of identified Department of Defense (DoD) sites with lead being the predominant heavy metal of concern. Solidification/stabilization methods are currently the most used in situ metal-contamination treatment technologies. The treatability study described in this report was designed to develop the information necessary to support the immobilization of lead contaminants in soil by in situ treatment with phosphate-based binders. The potential demonstration ... |
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| Identification of Protein Kinases Required for NF2 Signaling |
Dec-2007 |
7 pages |
| Authors:
Jonathan Chernoff; FOX CHASE CANCER CENTER PHILADELPHIA PA
|
| The purpose of this concept award grant is to uncover potential drug targets for treatment of Neurofibromatosis type 2 (NF2). We planned a synthetic lethal screen using RNAi technology to uncover protein kinases and phosphates that are specifically required for the survival of NF2-null cells. We also obtained and reformatted a murine siRNA library against all known protein kinases and phosphatases. We also obtained NF2flox/flox mouse embryo fibroblasts and used ... |
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| New Materials Based on Spider Silk |
06 NOV 2007 |
14 pages |
| Authors:
C. Vendrely; T. Scheibel; TECHNISCHE UNIV MUENCHEN (GERMANY)
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| In this project, we investigated the dragline silk proteins ADF-3 and ADF-4 of the spider Araneus diadematus. Adf-3 and Adf-4 cDNA can each be expressed directly in insect cells using the Baculovirus-expression-System. Recombinant ADF-4 is insolubly produced in the cytoplasm of insect cells and soluble produced upon secretion into the media. Further, parameters influencing stability and solubility of recombinantly produced ADF analogues have been investigated. We detected that intermolecular disulfide ... |
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| Novel Designs and Coupling Schemes for Affordable High Energy Laser Modules |
28 SEP 2007 |
74 pages |
| Authors:
Jerome V. Moloney; Axel Schulzgen; Pavel Polynkin; Masud Mansuripur; Mahmoud Fallahi; Yoel Fink; Chiping Chen; ARIZONA UNIV BOARD OF REGENTS TUCSON
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| This multi-disciplinary research effort developed new classes of compact, highly-doped Er/Yb phosphate-doped glass fibers as high power, low noise single wavelength, single mode oscillators. Three world record powers in low-noise, single frequency laser oscillators at the eyesafe wavelength of 1.55 micrometers were reported. The project vertically integrated fabrication, testing, and optimization of all components necessary for manufacturing of fiber laser units including highly doped specialty glasses, fiber preforms, fiber drawing ... |
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| Seismic Energy Generation and Partitioning into Various Regional Phases from Different Seismic Sources in the Middle East Region |
20 SEP 2007 |
85 pages |
| Authors:
Yefim Gitterman; Vladimir Pinsky; Rami Hofstetter; GEOPHYSICAL INST OF ISRAEL HOLON (ISRAEL)
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| The project was focused on studying, experimentally, features of seismic energy generation and partitioning of P and S waves from different explosive seismic sources, at near-source and regional distances, in the time and spectral domain. An extensive database of Ground Truth single-fired explosions was created. The explosions selected contain a broad variety of design features (buried and surface sources, tamped and decoupled shots, large diameter 0.5-0.8m borehole and near-spherical cavity ... |
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| Study of Photorefractive Beam Coupling in Sn2P2S6 in Reflection Grating Geometry |
31-May-2007 |
11 pages |
| Authors:
Odoulov S Georgievich; NATIONAL ACADEMY OF SCIENCES KIEV (UKRAINE) INST OF PHYSICS
|
| This report results from a contract tasking National Academy of Sciences as follows: This project belongs to the technology Area Physics: Optics and Lasers and more precisely it deals with the development of coherent optical amplifiers based on selfdiffraction from the dynamic gratings recorded by the weak signal beam to be amplified and much more powerful coherent pump beam. The main strategic goal of this project consists, in fact, not ... |
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| Improved Formulation of a Recombinant Ricin A-chain Vaccine Increases its Stability and Effective Antigenicity |
26 MAR 2007 |
11 pages |
| Authors:
John H. Carra; Robert W. Wannemacher; Ralph F. Tammariello; Changhong Y. Lindsey; Richard E. Dinterman; Rowena D. Schokman; Leonard A. Smith; ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD
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| Ricin is a potent toxin associated with bioterrorism for which no vaccine or specific countermeasures are currently available. A stable, non-toxic and immunogenic recombinant ricin A-chain vaccine (RTA 1-33/44-198) has been developed by protein engineering. We identified optimal formulation conditions for this vaccine under which it remained stable and potent in storage for up to 18 months, and resisted multiple rounds of freeze-thawing without stabilizing co-solvents. Reformulation from phosphate buffer ... |
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| Ln3+-Catalyzed Alcoholysis of Organophosphates: New Methodology for the Catalytic Transformation of Phosphorus Pesticides and CW Agents |
14 MAR 2007 |
13 pages |
| Authors:
Robert S. Brown; QUEEN'S UNIV KINGSTON (ONTARIO)
|
| The title project involved investigation of the metal ion catalyzed alcoholysis (e.g. methanolysis) of neutral organophophorus (OP)ester compounds. These included several members of the phosphate [(ArO)(RO)2P=O] and phosphorothioate [(ArS)(RO)2P=O] classes, as well as phosphonate [(ArO)CH3(OR)P=O] and phosphonothioate [(ArS)CH3(RO)P=O] classes. Some work was conducted on the P=S phosphorothionate esters which are common pesticides. In general it was found that La3+ ion, in the presence of one equivalent of alkoxide, provided an ... |
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| The Effect of Orthophosphate as a Copper Corrosion Inhibitor in High Alkalinity Drinking Water Systems |
MAR 2007 |
97 pages |
| Authors:
Stephen Grace; AIR FORCE INST OF TECH WRIGHT-PATTERSON AFB OH SCHOOL OF ENGINEERING AND MANAGEMENT
|
| The purpose of this research was to investigate orthophosphate as a corrosion inhibitor for copper pipe in a high-alkalinity drinking water system. Specifically, this thesis sought to answer three research questions regarding the impact of orthophosphate treatment, the nature of the mechanism by which orthophosphate controls copper corrosion, and the value of equilibrium modeling in predicting orthophosphate?s effects. The research questions were answered through a comprehensive literature review and experimental ... |
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| Prevention of Prostate Cancer by Inositol Hexaphosphate |
FEB 2007 |
19 pages |
| Authors:
Partha P. Banerjee; GEORGETOWN UNIV WASHINGTON DC
|
| Prostate cancer (PCa) is the most common invasive malignancy and second leading cause of cancer death in men in the United States. Up till now, hormone ablation therapy is the major way to treat PCa. Such therapy only causes a temporary regression and tumor growth resumes within 6-18 months. Therefore, better androgen blockade is not the answer for treating PCa. Rather, research efforts should focus on the therapeutic agents that ... |
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| Coimmobilization of a Redox Enzyme and a Cofactor Regeneration System |
JUL 2006 |
4 pages |
| Authors:
Lorena Betancor; Cecile Berne; Heather R. Luckarift; Jim C. Spain; GEORGIA INST OF TECH ATLANTA SCHOOL OF CIVIL AND ENVIRONMENTAL ENGINEERING
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| The co-immobilization of nitrobenzene nitroreductase and glucose-6-phosphate dehydrogenase in silica particles enables the continuous conversion of nitrobenzene to hydroxylaminobenzene with NADPH recycling. |
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| Relating the Biogeochemistries of Zinc, Cobalt, and Phosphorus to Phytoplankton Activities in the Sea |
JUN 2006 |
|
| Authors:
Rachel J. Wisniewski; MASSACHUSETTS INST OF TECH CAMBRIDGE JOINT PROGRAM IN APPLIED OCEAN SCIENCE AND ENGINEERING
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 | This thesis explores the potential of zinc, cobalt and phosphorus to influence phytoplankton production. In the North Pacific and Bering Sea, total zinc concentrations were measured in the near-surface and in deep profiles. Zinc speciation was measured with a novel anodic stripping voltammetry method. Zinc's ability to influence primary production in the North- Pacific was demonstrated in a shipboard incubation and by comparing two phytoplankton pigments to zinc concentrations. In ... |
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| Transitioning Submersible Chemical Analyzer Technologies for Sustained, Autonomous Observations From Profiling Moorings, Gliders and other AUVs |
2006 |
8 pages |
| Authors:
Alfred K. Hanson; Percy L. Donaghay; Casey Moore; Richard Arrieta; SUBCHEM SYSTEMS INC JAMESTOWN RI
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| The long term goal is to transition existing prototype autonomous profiling nutrient analyzers into commercial products that can be readily deployed on autonomous profiling moorings, coastal gliders and propeller driven unmanned underwater vehicles and used for sustained, autonomous ocean observations of chemical distributions and variability. A series of issues have been identified that need to be addressed to convert prototype nutrient analyzers into commercial units that can be widely used ... |
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| Enhancing the Immunogenicity of a Dengue-2 DNA Vaccine With Adjuvants and Anti-FCyRI Antibodies |
OCT 2005 |
17 pages |
| Authors:
Kevin R. Porter; Shuenn-Jue Wu; Kanakatte Raviprakash; NAVAL MEDICAL RESEARCH CENTER SILVER SPRING MD
|
| The objective is to use adjuvants to enhance the immunogenicity of a dengue (DEN) DNA vaccine. The adjuvants to be evaluated in this project included aluminum phosphate, tetanus toxoid and anti-Fc R monoclonal antibodies chemically linked to the DNA vaccine. Multiple attempts to link the anti-Fc R monoclonal antibody to the DNA vaccine resulted in a poor efficiency in the linkage reaction using thiol linkage chemistry. An alternative approach using ... |
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| Rainfall Lysimeter Evaluation of Leachability and Surface Transport of Heavy Metals From Six Soils With and Without Phosphate Amendment |
SEP 2005 |
89 pages |
| Authors:
Steven Larson; Barbara Tardy; Ken Rainwater; Jeb S. Tingle; ENGINEER RESEARCH AND DEVELOPMENT CENTER VICKSBURG MS
|
| The addition of phosphate materials such as hydroxyapatite (HAP) has been suggested and used for treatment and stabilization of lead-contaminated soils. HAP has been used at some small arms firing ranges (SAFRs) to contain the lead in berm soils onsite. The two primary pathways for lead migration from the sites are via leachate production and surface runoff water from rainfall. The focus of this study is the in situ treatment ... |
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| High Sensitivity Detection of Bacterial Endospores via TB Photoluminescence Enhancement |
17 AUG 2005 |
8 pages |
| Authors:
Nicholas F. Fell Jr.; Paul M. Pellegrino; James B. Gillespie; ARMY RESEARCH LAB ADELPHI MD
|
| Detecting bacterial endospores is a critical challenge to bioanalytical chemistry, since a number of serious diseases and health problems are caused by members of the sporeforming genera Bacillus and Clostridium. We have developed a highly sensitive method for their detection and have demonstrated detection limits of less than 5000 CFU/ml. Our method is based on the presence of a marker compound in bacterial endospores, dipicolinic acid (dpa). When complexed with ... |
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| High Temperature Coatings by Pulsed Electron Beam Ablation |
AUG 2005 |
44 pages |
| Authors:
Olivier Sudre; David B. Marshall; Sergio Lucato; ROCKWELL SCIENTIFIC CO THOUSAND OAKS CA
|
| The objective of this program was to investigate the deposition and properties of new high temperature coatings using pulsed-electron-beam ablation (PEBA) and to characterize the corrosion of those compounds in relevant environments. The PEBA technique has potential advantages for depositing compounds that are known to be difficult to deposit by conventional electron-beam evaporation. The use of ablation rather than melting and evaporation avoids changes in composition associated with differing evaporation ... |
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| Synthesis, Sintering and Microstructural Characterization of Nanocrystalline Hydroxyapatite Composites |
13 JUL 2005 |
6 pages |
| Authors:
B. Viswanath; N. Ravishankar; Suprabha Nayar; Arvind Sinha; INDIAN INST OF SCIENCE BANGALORE
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| Nanocrystalline hydroxyapatite (HAp) exhibits better bioactivity and biocompatibility with enhanced mechanical properties compared to the microcrystalline counterpart. In the present work, nanocrystalline hydroxyapatite was synthesized by wet chemical method. Sintering was carried out with nanocrystalline alumina as additive, the content of alumina being varied from 10 to 30 wt% in the composite. For 20 and 30 wt % Al2O3, hydroxyapatite decomposed into tricalcium phosphate (TCP) above the sintering temperature of ... |
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| A Novel Polymer-Synthesized Ceramic Composite Based System for Bone Repair: Osteoblast Growth on Scaffolds with Varied Calcium Phosphate Content |
13 JUL 2005 |
5 pages |
| Authors:
Yusuf M. Khan; Dhirendra S. Katti; Cato T. Laurencin; DREXEL UNIV PHILADELPHIA PA
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| Polymer/ceramic composite matrices for bone tissue engineering were constructed by synthesizing a poorly crystalline calcium phosphate within poly(lactide-co-glycolide) microspheres that were subsequently fused together to form 3-dimensional structures. Calcium ion dissolution from the composite matrices in simulated body fluid was examined over a 24 hour period. The initial 4 hour period showed an increase in calcium ion concentration, whereas, a decrease in calcium ion concentration was noted thereafter. This decrease ... |
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| Physical and Mechanical Properties and Fire, Decay, and Termite Resistance of Treated Oriented Strandboard |
MAY 2005 |
9 pages |
| Authors:
Nadir Ayrilmis; S. N. Kartal; Theodore L. Laufenberg; Jerrold E. Winandy; Robert H. White; DEPARTMENT OF AGRICULTURE MADISON WI
|
| This study evaluated the effects of a number of chemicals on the physical and mechanical properties and fire, decay, and termite resistance of oriented strand board (OSB) panels. Disodium octaborate tetrahydrate (DOT), boric acid (BA), melamine phosphate (MP), and a BA/DOT mixture were sprayed onto the furnish at varying concentrations. The panels were tested for thickness swell, eater absorption, modulus of rupture, modulus of elasticity, and internal bond strength according ... |
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| Examination of Alternative Pretreatments to Hexavalent Chromium Based DOD-P-15328D Wash Primer for MIL-A-46100D High Hard Steel Armor |
JAN 2005 |
52 pages |
| Authors:
Brian E. Placzankis; Chris E. Miller; John V. Kelley; ARMY RESEARCH LAB ABERDEEN PROVING GROUND MD
|
| Hexavalent Chromium based compounds with their associated health and environmental risks have necessitated reductions and even eliminations of their usage in U.S. Army weapon systems. These compounds are primarily associated with pretreatments and conversion coatings applied prior to primers and topcoats that make up the Chemical Agent Resistant Coating (CARC) coating system. Despite these hazards, for armor steels such as MIL-A-46100D high hard alloy, hexavalent chromium based DOD-P-15328D wash primer ... |
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| Analysis of Active-Site Amino-Acid Residues of Human Serum Paraoxonase Using Competitive Substrates |
2005 |
7 pages |
| Authors:
David T. Yeung; David E. Lenz; Douglas M. Cerasoli; ARMY MEDICAL RESEARCH INST OF CHEMICAL DEFENSE ABERDEEN PROVING GROUND MD
|
| Serum paraoxonase (PON1) is a calcium-dependent six-fold beta-propeller protein structurally similar to the di-isopropylfluorophosphatase (DFPase) found in the squid Loligo vulgaris. Human serum paraoxonase (HuPON1) has been shown to hydrolyze an array of substrates even though relatively little is known about its physiological role(s) or its catalytic mechanism. Through site-directed mutagenesis studies, designed from a DFPase-like homology model, and from a crystal structure of a hybrid PONl molecule, amino-acid residues ... |
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| Ground-Water Reconnaissance of the Bijou Creek Watershed, South Lake Tahoe, California, June-October 2003 |
2005 |
41 pages |
| Authors:
GEOLOGICAL SURVEY WASHINGTON DC
|
| A ground-water reconnaissance study of the Bijou Creek watershed in South Lake Tahoe California was done during the summer and early fall of 2003. This study provides basic hydrologic data for a region in the Lake Tahoe Basin in which a continuing loss of lake clarity is occurring in the a nearshore zone of Lake Tahoe. Wells, springs, and a surface-water site were located and basic hydrologic data were collected. ... |
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| Adenosine Receptor Agonist Pd 81,723 Protects Against Seizure/Status Epilepticus and Neuropathology Following Organophosphate Exposure |
17 NOV 2004 |
17 pages |
| Authors:
Jaimee R. Compton; Stacy M. Crawford; Ruthie H. Ratcliffe; Keith H. Steele; Richard K. Gordon; Madhusoodana P. Nambiar; WALTER REED ARMY INST OF RESEARCH SILVER SPRING MD
|
| A novel approach to broad-specificity medical countermeasure against chemical warfare nerve agent (CWNA) poisoning is by preventing excessive accumulation of ACh attributable to AChE inhibition of CWNA exposure. The effectiveness of various partial adenosine A1 receptor agonists as post-CWNA exposure (1 hour) neuroprotectants was investigated in the study using a rat seizure/status epilepticus model that employs the organophosphate diisopropylfluorophosphate, a surrogate comparable to the nerve agent soman. Physiological data collected ... |
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| Enzymatic Decontamination of C/B Threat Materials: From Concept to Commercialization |
17 NOV 2004 |
7 pages |
| Authors:
Joseph J. Defrank; Steven P. Harvey; Vipin K. Rastogi; Tu-chen Cheng; Christopher S. Penet; EDGEWOOD CHEMICAL BIOLOGICAL CENTER ABERDEEN PROVING GROUND MD
|
| The ability of enzymes to hydrolyze and detoxify organophosphorus compounds goes back nearly 60 years to when Mazur published work with mammalian tissues conducted during World War II (Mazur, 1946). He determined that enzymatic activity in a variety of tissues could catalytically detoxify diisopropylfluorophosphate (DFP). More recently, a variety of enzymes with activity against G- and V-type nerve agents as well as organophosphorus pesticides have been identified from numerous sources, ... |
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| Gaseous Dimethyl Dioxirane As A Decontaminant For Simulants Of Chemical & Biological Weapons |
16 NOV 2004 |
6 pages |
| Authors:
Susan D. Miller; Karen E. Bushway; APPLIED RESEARCH ASSOCIATES INC TYNDALL AFB FL
|
| Gaseous dimethyl dioxirane (DMDO) was evaluated as a decontaminant for simulants of chemical and biological warfare agents (CBW). Isolated DMDO was present as a liquid in CFC 113 or the fluorinated ether, Novec HFE 7100" (3M) and was easily vaporized under reduced pressure. The Hagent simulant, thioanisole, and the G-agent simulants, paraoxon and diphenyl chlorophosphate (DPCP), were efficiently neutralized in less than an hour. In addition, Bacillus subtilis spores were ... |
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| Selective Cytotoxic Phospholipids for Prostate Cancer |
OCT 2004 |
68 pages |
| Authors:
Duane D. Miller; TENNESSEE UNIV MEMPHIS
|
| The goal of this project is to build upon our discovery of two phospholipid lead compounds, serine amide phosphate (SAP) and serine diamide phosphate (SDAP), that have been shown to be selective in their cytotoxic actions in PC-3 and DU-145 prostate caner cells respectively. These agents were originally designed as part of a series of compounds to inhibit lysophosphatidic acid (LPA), a phospholid growth factor. After discovering the antiproliferation activity ... |
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| Enhancing the Immunogenicity of a Dengue-2 DNA Vaccine with Adjuvants and Anti-Fc(gamma)RI Antibodies |
OCT 2004 |
15 pages |
| Authors:
Kevin R. Porter; Shuenn-Jue Wu; Kanakatte Raviprakash; NAVAL MEDICAL RESEARCH CENTER SILVER SPRING MD
|
| The objective is to use adjuvants to enhance the immunogenicity of a dengue (DEN) DNA vaccine. The adjuvants to be evaluated in this project include aluminum phosphate, tetanus toxoid and anti-Fc(gamma)R monoclonal antibodies chemically linked to the DNA vaccine. Multiple attempts to link the anti-Fc(gamma)R monoclonal antibody to the DNA vaccine resulted in a poor efficiency in the linkage reaction using thiol linkage chemistry. An alternative approach using hydrazine and ... |
|
| Magnetic Resonance Studies of Photosensitizers and Their Effect in Tumors |
OCT 2004 |
94 pages |
| Authors:
Subbaraya Ramaprasad; NEBRASKA UNIV MEDICAL CENTER OMAHA
|
| In this project we used specifically fluorine labeled photosensitizers which will be of utility in the treatment of breast cancer via photodynamic therapy(PDT). The accumulation of the photosensitizer in the tumor and the muscle were evaluated using noninvasive 19F spectroscopic modality in mice bearing RIF tumor. By determining the relative disposition of the sensitizer we can determine the best time to irradiate the tumor causing minimal damage to nearby healthy ... |
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| 99-Technetium Sestamibi Scanning to Predict the Efficacy of Estramustine Phosphate in Overcoming Paclitaxel Resistance in Patients with Advanced Breast Cancer |
SEP 2004 |
6 pages |
| Authors:
Matthew D. Volm; NEW YORK UNIV NY SCHOOL OF MEDICINE
|
| The purpose of this research was to investigate the ability of 99- Technetium Sestamibi (Tc-99-SM) to serve as a non-invasive means of assessing the presence of clinically relevant drug resistance in patients with advanced breast cancer. Tc-99-SM is a substrate of the p-glycoprotein, the transmembrane drug efflux transporter involved in classic multi-drug resistance (MDR). We proposed to the hypothesis that rapid clearance of Tc-99-SM correlates with the presence of functional ... |
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| Toward Optically Monitored Cytosensors |
17 MAY 2004 |
5 pages |
| Authors:
Philip N. McFadden; OREGON STATE UNIV CORVALLIS
|
| Fish scales display arrays of thousands of colored living cells known as chromatophores. In this study, the use of color changes in isolated lish scales was evaluated as a rapid warning signal for delayed neurotoxic agents. The focus was on detecting delayed effects of organophosphate nerve agents like sarin, though the less toxic diisopropylfluorophosphate (DFP) was used as a sirnulant. DFP caused rapid and long-lasting scale color changes. These signals ... |
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| A Compilation of Rate Parameters of Water-Mineral Interaction Kinetics for Application to Geochemical Modeling |
MAR 2004 |
71 pages |
| Authors:
James L. Palandri; Yousif K. Kharaka; GEOLOGICAL SURVEY MENLO PARK CA
|
| Geochemical reaction path modeling is useful for rapidly assessing the extent of water-aqueous-gas interactions both in natural systems and in industrial processes. Modeling of some systems, such as those at low temperature with relatively high hydrologic flow rates, or those perturbed by the subsurface injection of industrial waste such as CO2 or H2S, must account for the relatively slow kinetics of mineral-gas-water interactions. We have therefore compiled parameters conforming to ... |
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| Selective Detection and Identification of Sugar Nucleotides by CE-Electrospray-MS and Its Application to Bacterial Metabolomics |
01 FEB 2004 |
9 pages |
| Authors:
Evelyn C. Soo; Annie J. Aubry; Susan M. Logan; Patricia Guerry; N. M. Young; Pierre Thibault; NATIONAL RESEARCH COUNCIL OF CANADA OTTAWA (ONTARIO) DIV OF BIOLOGICAL SCIENCES
|
| A novel method employing CE-ESMS and precursor ion scanning was developed for the selective detection of nucleotide-activated sugars. By using precursor ion scanning for fragment ions specific to the different nucleotide carriers, i.e., ions at m/z 322 for cytidine monophosphate, m/z 323, 385, and 403 for uridine diphosphate, m/z 362, 424, and 442, for guanosine diphosphate, and m/z 346, 408, and 426 for adenosine diphosphate, it was possible to selectively ... |
|
| Surface- and Ground-Water Monitoring and Mapping of Selected Features at the Blue Ridge Parkway Mt. Pisgah Campground, Haywood County, North Carolina, 2002 |
2004 |
40 pages |
| Authors:
Douglas G. Smith; GEOLOGICAL SURVEY RESTON VA WATER RESOURCES DIV
|
| During 2002, a baseline study of hydrologic conditions was conducted, and selected features were mapped within the Mt. Pisgah campground on the Blue Ridge Parkway in Haywood County, North Carolina. Field surveys were performed by using global positioning system equipment one time (January 2002) during the study to locate hydrologic and other types of features in the study area. Water-level and streamflow data and seasonal water-quality samples were collected from ... |
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| Bone Tissue Scaffold Technologies Based on RP Adopted Droplet Assembly |
19 NOV 2003 |
10 pages |
| Authors:
Renji Zhang; Yongnian Yan; Feng Lin; TSINGHUA UNIV BEIJING (CHINA) DEPT OF MECHANICAL ENGINEERING
|
| Tissue engineering tries to grow replacement tissues to repair damaged bones. In this paper, the fabrication technology of Multi-nozzle Deposition Manufacturing (MDM) was adopted to fabricate scaffolds of a tissue engineered bone at low temperature. The composite of poly(L-lactic acid) and tri-calcium phosphate (TCP) was chosen to form bone tissue engineering scaffolds. The new computer aided manufacturing process can make porous PLLA/TCP scaffolds. A new surface processing technology of apatite ... |
|
| Enhancing the Immunogenicity of a Dengue-2 DNA Vaccine with Adjuvants and Anti-FCgammaRI Antibodies |
OCT 2003 |
12 pages |
| Authors:
Kevin R. Porter; NAVAL MEDICAL RESEARCH CENTER SILVER SPRING MD
|
| The objective is to use adjuvants to enhance the immunogenicity of a dengue (DEN) DNA vaccine. The adjuvants to be evaluated in this project include aluminum phosphate, tetanus toxoid and anti-FcyR monoclonal antibodies chemically linked to the DNA vaccine. Initial attempts to link the anti-FcyR monoclonal antibody to the DNA vaccine resulted in a poor efficiency in the linkage reaction. An alternative method of adding the thiol group (EndTag Nucleic ... |
|
| Chemical Stabilization of Lead in Small Arms Firing Range Soils |
SEP 2003 |
66 pages |
| Authors:
Barbara A. Tardy; R. M. Bricka; Steven L. Larson; ENGINEER RESEARCH AND DEVELOPMENT CENTER VICKSBURG MS ENVIRONMENTAL LAB
|
| The U.S. military operates Small Arms Firing Ranges (SAFRs) at various locations in and outside the United States. The ranges are used for munitions training for military personnel. Because the ranges have been in operation for a number of years, the soils at SAFRs are contaminated with spent munitions, lead bullets, and other metal contaminants. Although SAFR projectiles contain primarily lead, copper, and antimony, lead is by far the most ... |
|
| Environmental Impact of New Chemical Agents for Fire Suppression |
28 AUG 2003 |
86 pages |
| Authors:
Robert E. Huie; CORPS OF ENGINEERS WASHINGTON DC STRATEGIC ENVIRONMENTAL RESEARCH AND DEVELOPMENT PROGRAM
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| The environmental impact of chemical agents is intimately tied to the environmental transformations these chemicals undergo. In this project, the most important transformations for various classes of proposed fire suppression agents were investigated and, for the important case of hydrogen abstraction by hydroxyl radicals, a computational screening tool was developed. Rate constants for hydroxyl radical reactions with hydrofluoroethers, perfluoronated alkenes, bromine-containing fluoroalkenes, and fluoroalkanes, were determined. By using the computational ... |
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| Magnetic Resonance Studies of Photosensitizers and Their Effect in Tumors |
AUG 2003 |
82 pages |
| Authors:
Subbaraya Ramaprasad; NEBRASKA UNIV MEDICAL CENTER OMAHA
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| In this project, we use specifically fluorine labeled photosensitizers which will be of utility in the treatment of breast cancer via photodynamic therapy (PDT). The accumulation of the photosensitizer in the tumor and the muscle are evaluated using noninvasive 19F spectroscopic modality in mice bearing RIF tumor. By determining the relative disposition of the sensitizer, we can determine the best time to irradiate the tumor causing minimal damage to nearby ... |
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| Cleavage of Phosphates, Phosphonates, Phosphonothioates, and Phosphodiesters |
JUN 2003 |
10 pages |
| Authors:
Robert A. Moss; RUTGERS - THE STATE UNIV NEW BRUNSWICKNJ DEPT OF CHEMISTRY
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| This is a Final Progress Report for "Cleavage of Phosphates, Phosphonates, Phosphonothioates, and Phosphonodiesters." It reviews 13 publications on these topics which have been underwritten by this grant. |
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| Structural Effects on the Physical Properties of Ionic Liquids |
06 MAY 2003 |
23 pages |
| Authors:
Greg Drake; John Wilkes.; AIR FORCE RESEARCH LAB EDWARDS AFB CA PROPULSION DIRECTORATE
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| Ionic liquids are a class of salts consisting of cation/anion pair that has a very low melting point. Definition of an ionic liquid is open to some debate amongst researchers in the area, but most in the are use of two. 1) An ionic compound that melts below 100 degrees C (b.p. of H2O). 2)An ionic compound that has a melting point at or below ambient temperatures. These are often ... |
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| Powder Coatings as an Environmentally Acceptable Alternate to the System of MIL-P-53022 and MIL-PRF-22750 |
MAY 2003 |
16 pages |
| Authors:
Jeffrey L. Duncan; ARMY RESEARCH LAB ABERDEEN PROVING GROUND MD
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| In late 2000, Albany Marine Corps Logistics Base (MCLB) personnel contacted the Coatings Technology Team, Weapons and Materials Research Directorate, US Army Research Laboratory (ARL) about a test program designed to approve the use of epoxy powder coatings as replacements for the standard chemical agent resistant coating (CARC) system used on tactical equipment, because ARL is the CARC Commodity Manager and the CARC approving authority for the Department of Defense. ... |
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| Structural Effects on the Physical Properties of Ionic Liquids |
31 MAR 2003 |
3 pages |
| Authors:
Greg Drake; Tom Hawkins; John Wilkes; AIR FORCE RESEARCH LAB EDWARDS AFB CA SPACE AND MISSILE PROPULSION DIV
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| Recently work using ionic liquids has risen exponentially in both academic research efforts as well as by industrial large-scale organic synthesis. Much of these efforts have centered around the use of di-alkyl substituted imidazolium salts with an array of anions, many of which are commercially available. The pioneering work carried out by the USAF in the last several decades has shed some light upon some of the physical property effect ... |
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Reports by Keyword(s)
PHOSPHATES
