| Importance of Virtual Reality to a Controlled Stimulus |
Oct 2012 |
7 pages |
| Authors:
Robert McLay; GENEVA FOUNDATION TACOMA WA
|
 | This study is a follow up to two projects, funded by the Office of Naval Research, which demonstrated that Virtual Reality (VR) Exposure Therapy was safe for the treatment of combat PTSD Disorder, and that it worked better than treatment as usual. In this study, we are attempting to discover if the Virtual Reality is actually the active component of the treatment. Participants with PTSD are randomized to receive the ... |
|
| Novel Therapeutic Targets for Chronic Migraine |
Sep 2012 |
7 pages |
| Authors:
Andrew Charles; Peter Goadsby; CALIFORNIA UNIV LOS ANGELES
|
| Chronic migraine is a disabling disorder that affects millions of individuals worldwide, and may result from traumatic brain injury. The purpose of this study is to use rodent models of basic migraine mechanisms to characterize new potential treatments for chronic migraine. The scope of the research is to investigate multiple novel potential drug treatments on migraine-related brain excitability, pain-sensing mechanisms, and behavior. The major findings of the research in the ... |
|
| Excessive Cap-dependent Translation as a Molecular Mechanism Underlying ASD |
Aug 2012 |
14 pages |
| Authors:
Eric Klann; NEW YORK UNIV NY
|
| We hypothesize that excessive cap-dependent translation is a causative factor in autism spectrum disorder (ASD). To test this hypothesis, we have been studying transgenic mice that overexpress eIF4E have been testing the following specific aims: 1) to determine whether eIF4E transgenic mice display behaviors consistent with ASD, 2) to determine whether ASD-like behaviors displayed by eIF4E transgenic mice can be reversed by novel cap-dependent translation inhibitors, and 3) to determine ... |
|
| Understanding the Etiology of Tuberous Sclerosis Complex |
Jul 2012 |
56 pages |
| Authors:
Angelique Bordey; YALE UNIV NEW HAVEN CT
|
| Tuberous Sclerosis Complex (TSC) is a genetic multisystem disorder characterized by severe neurological symptoms (e.g. seizures), which are the most significant causes of disability and morbidity. Presently, there are no known cures for TSC and the etiology of the disease is not well understood, perhaps due to the lack of model system to study this disorder. In TSC patients, mutations in Tsc1 or Tsc2, result in the formation of lesions. ... |
|
| Predictors of Treatment Response to Fluoxetine in PTSD Following a Recent History of War Zone Stress Exposure |
Jul 2012 |
18 pages |
| Authors:
Paul S Hicks; Michael L Adams; Brett Litz; Keith Young; Jed Goldart; Tom Velez; Walter Penk; Kathryn Kotria; TEMPVA RESEARCH GROUP INC TEMPLE TX
|
| Although selective serotonin reuptake inhibitors (SSRIs) are routinely prescribed for acute stress disorder and early PTSD and recommended in the VA-DoD best practice guidelines, the efficacy of SSRIs as an early intervention for PTSD in service members returning from war-zone duty has still not been determined. Consequently, this study was designed to conduct a controlled trial of fluoxetine as an early intervention for recently redeployed soldiers, as well as to ... |
|
| The Risk of Mental Health Disorders Among U.S. Military Personnel Infected with Human Immunodeficiency Virus, Active Component, U.S. Armed Forces, 2000-2011 |
May 2012 |
5 pages |
| Authors:
Raul A Mirza; Angelia Eick-Cost; Jean L Otto; ARMED FORCES HEALTH SURVEILLANCE CENTER SILVER SPRING MD
|
| Mental health disorders (MHD) are reportedly more common among soldiers and airmen with HIV than their seronegative counterparts. This report documents the incidence rates of MHD among HIV-positive members of all service branches and compares the rates to those of two HIV-unexposed control groups: an HSV2-infected group and a group without documented HIV or HSV2 infections. Approximately 56 percent of HIV-infected service members received an incident diagnosis of a MHD ... |
|
| Degenerative Disc Disease, Active Component, U.S. Armed Forces, 2001-2011 |
May 2012 |
5 pages |
| Authors:
Dariusz Mydlarz; INTUIDEX INC HELLERTOWN PA
|
| Degeneration of intervertebral discs is a common disorder that often leads to pain syndromes and mechanical dysfunction of the spine. Between 2001 and 2010, 131,986 active component service members received diagnoses of degenerative disc disease (DDD) during a hospitalization or at least two ambulatory visits (overall crude incidence rate: 951.4 per 100,000 person-years [p-yrs]). Annual crude incidence rates more than doubled during the surveillance period (2001: 614.9 per 100,000 p-yrs; ... |
|
| Validating Diagnostic and Screening Procedures for Pre-Motor Parkinson's Disease |
Apr 2012 |
7 pages |
| Authors:
J W Langston; PARKINSONS INST SUNNYVALE CA
|
| The goal of this 24-month proposal is to establish the critical infrastructure for the initiation of a five year prospective follow-up study to identify those at risk for developing PD or a related Lewy body disorder in three study populations. The ultimate goal of this work is to develop low-cost non-invasive screening methods to detect pre-motor Parkinson s disease (PD) that can be implemented population-wide. Our hypothesis is that cardiac ... |
|
| Neural Mechanisms Linking Mild Traumatic Brain Injury and Anxiety States in an Animal Model |
01 Mar 2012 |
60 pages |
| Authors:
Gina Forster; SOUTH DAKOTA UNIV VERMILLION
|
| Previous correlational studies suggest that mild traumatic brain injury (TBI) is associated with an increase in the prevalence of anxiety disorders, including posttraumatic stress disorder (PTSD). By using a relevant animal model, this research demonstrates that mild TBI can result in increased fear learning and anxiety states that mimic the symptoms of generalized anxiety disorder and PTSD. Furthermore, this research suggests that heightened fear and anxiety states following mild TBI ... |
|
| Genetics of Eosinophilic Esophagitis |
Mar 2012 |
36 pages |
| Authors:
Marc Rothenberg; CHILDREN'S HOSPITAL MEDICAL CENTER CINCINNATI OH
|
| Eosinophilic esophagitis (EE) is an emerging worldwide food allergic disorder associated with polysensitization to multiple food allergens, resulting in greatly restricted diets and chronic gastroesophageal reflux disease-like symptoms in many individuals. EE has a strong genetic component based on the frequent presence of a familial inheritance pattern, the high sibling risk ratio (80-fold) and the demonstration that a single nucleotide polymorphism (SNP) in the eotaxin-3 gene confers disease susceptibility. In ... |
|
| Prevention of Post Traumatic Stress Disorder among Military Health Care Workers: A Systematic Review |
Jan 2012 |
15 pages |
| Authors:
Christopher A Orsello; Christopher A Alfonzo; NAVAL AEROSPACE MEDICAL INST PENSACOLA FL
|
| Studies indicate that Posttraumatic Stress Disorder (PTSD) is not uncommon among medical personnel serving in the military and that its prevention remains a significant challenge. While extensive PTSD research findings exist that are generalizable to the military dedicated research specific to its at-risk population of medical workers is less common. The purpose of this review is to perform a systematic search for the most effective strategies in the prevention of ... |
|
| Predictors of Risk and Resilience for Posttraumatic Stress Disorder Among Ground Combat Marines: Methods of the Marine Resiliency Study |
Jan 2012 |
12 pages |
| Authors:
Dewleen G Baker; William P Nash; Brett T Litz; Mark A Geyer; Victoria B Risbrough; Caroline M Nievergelt; Daniel T O'Connor; Gerald E Larson; Nicholas J Schork; Jennifer J Vasterling; CENTERS FOR DISEASE CONTROL AND PREVENTION ATLANTA GA
|
| The Marine Resiliency Study (MRS) is a prospective study of factors predictive of posttraumatic stress disorder (PTSD) among approximately 2,600 Marines in 4 battalions deployed to Iraq or Afghanistan. We describe the MRS design and predeployment participant characteristics. Starting in 2008, our research team conducted structured clinical interviews on Marine bases and collected data 4 times: at predeployment and at 1 week, 3 months, and 6 months postdeployment. Integrated with ... |
|
| The Relationship between Posttraumatic Stress Disorder Checklist (PCL) Symptom Endorsement and Self-Reported Symptoms of Anxiety and Depression |
Jan 2012 |
7 pages |
| Authors:
Scott D Barnett; Susanne Gibbons; Edward J Hickling; UNIFORMED SERVICES UNIV OF THE HEALTH SCIENCES BETHESDA MD
|
| Post traumatic Stress Disorder (PTSD) has been a controversial diagnosis with arguments that the disorder could be better classified as a dissociative disorder, grief reaction, or a stress reaction rather than an anxiety disorder. This study identified individuals who self reported feeling anxious, and also met criterion for PTSD using data from activeduty military personnel who completed the 2008 Health Related Behaviors Questionnaire. Participants included those who 1) self-reported feelings ... |
|
| Analysis of Citalopram and Desmethylcitalopram in Postmortem Fluids and Tissues Using Liquid Chromatography-Mass Spectrometry |
Oct 2011 |
16 pages |
| Authors:
Russell J Lewis; Mike K Angier; Robert D Johnson; Brittany M Rains; Sarik Nepal; FEDERAL AVIATION ADMINISTRATION OKLAHOMA CITY OK CIVIL AEROSPACE MEDICAL INST
|
| Citalopram is a selective serotonin reuptake inhibitor that is a commonly prescribed drug for the treatment of depression, obsessive-compulsive disorder, panic disorder, anxiety disorder, and post-traumatic stress disorder. While the use of citalopram is relatively safe, certain side effects could negatively affect a pilot s performance and become a factor in an aviation accident. The side effects of this medication include nausea, tiredness, drowsiness, dizziness, and blurred vision. Due to ... |
|
| Seeking Safety Therapy for PTSD, TBI, and Substance Use Disorder |
Oct 2011 |
64 pages |
| Authors:
Lisa M Najavits; TREATMENT INNOVATIONS LLC NEWTON CENTER MA
|
| The purpose of this study is to conduct a randomized controlled trial of Seeking Safety (SS) therapy for TBI patients with PTSD and substance use disorder, comparing SS to treatment-as-usual, with a sample of 60 patients and 15 clinicians. This year, we had two unanticipated setbacks. but also made major progress. The setbacks were the loss of sites due to points of contact retiring or being reassigned; and the exceptionally ... |
|
| Using Propranolol to Block Memory Reconsolidation in Female Veterans with PTSD |
Oct 2011 |
5 pages |
| Authors:
Deane Aikins; YALE UNIV NEW HAVEN CT
|
| One of the hallmark features of Posttraumatic Stress Disorder (PTSD) is a marked increased in physical arousal (i.e., increased heart rate, muscle tension, etc.) when recalling a trauma-related memory. In this manner, a treatment that decreased the hyper-arousal of a traumatic memory to less-impairing levels may do well in allowing an individual with PTSD to return to his or her daily life. However, there is an imbalance at the heart ... |
|
| Importance of Virtual Reality to a Controlled Stimulus |
Oct 2011 |
7 pages |
| Authors:
Robert McLay; GENEVA FOUNDATION LAKEWOOD WA
|
| This study is a follow up to two projects, funded by the Office of Naval Research, which demonstrated that Virtual Reality (VR) Exposure Therapy was safe for the treatment of combat PTSD Disorder, and that it worked better than treatment as usual. In this study, we are attempting to discover if the Virtual Realty is actually the active component of the treatment. Participants with PTSD are randomized to receive the ... |
|
| Computerized Tailored Intervention for Behavioral Sequelae of Post-Traumatic Stress Disorder in Veterans |
Sep 2011 |
13 pages |
| Authors:
James L Spira; PACIFIC HEALTH RESEARCH INST HONOLULU HI
|
| This project assesses the usability and feasibility of a multi-behavioral computerized tailored intervention (CTI) or expert system delivered via the Internet for veterans with Post-Traumatic Stress symptoms. Three behavioral health risk factors, (1) smoking, (2) depression, and (3) stress, that are associated with PTSD, will be included in the CTI system. The project will adapt and modify a CTI system based on the Transtheoretical Model of Behavior Change (TTM) that ... |
|
| Regional Center of Excellence for PTSD: Phoebe Putney Memorial Hospital |
Sep 2011 |
60 pages |
| Authors:
Steven Ziemba; Fonta High; Lori-Ann Landry; PHOEBE PUTNEY MEMORIAL HOSPITAL ALBANY GA
|
| Post Traumatic Stress Disorder (PTSD) has been recognized by the Armed Forces as a significant mental health condition among returning US military personnel from Iraq and Afghanistan. Multiple challenges exist in the successful diagnosis and treatment of soldiers prior to symptoms becoming unmanageable and leading to dysfunction within families, homes, work, and in severe cases increased suicide rates. The current study will investigate the use of telepsychiatry services for military ... |
|
| Osteoclast Inhibitory Peptide-1 Therapy for Paget's Disease |
Aug 2011 |
22 pages |
| Authors:
Sakamuri Reddy; SOUTH CAROLINA STATE DEPT OF EDUCATION CHARLESTON SC
|
| Paget's disease of bone (PDB) is a chronic focal skeletal disorder that affects 2-3% of the population over the age of 60 yr. PDB is inherited as an autosomal dominant trait with genetic heterogeneity and characterized by highly localized areas of bone turnover with increased osteoclast (OCL) actively followed by an exaggerated osteoblast response. |
|
| Predictors of Treatment Response to Fluoxetine in PTSD Following a Recent History of War Zone Stress Exposure |
Jul 2011 |
49 pages |
| Authors:
Paul B Hicks; Michael L Adams; Brett Litz; Keith Young; Jed Goldart; Tom Velez; Walter Penk; Kathryn Kotrla; TEMPVA RESEARCH GROUP INC TEMPLE TX
|
| Although selective serotonin reuptake inhibitors (SSRIs) are routinely prescribed for acute stress disorder and early PTSD and recommended in the VA-DoD best practice guidelines, the efficacy of SSRIs as an early intervention for PTSD in service members returning from war-zone duty has still not been determined. Consequently, this study was designed to conduct a controlled trial of fluoxetine as an early intervention for recently redeployed soldiers, as well as to ... |
|
| Prazosin for Treatment of Patients with PTSD and Comorbid Alcohol Dependence |
Jul 2011 |
6 pages |
| Authors:
Ismene Petrakis; YALE UNIV NEW HAVEN CT
|
| There is a high rate of comorbidity with alcohol dependence (AD) and post traumatic stress disorder (PTSD). The rates of PTSD among individuals with AD are at least twice as high as those in the general population. In addition, alcohol dependence is the most common comorbid in men with PTSD. Despite this, little is known about how to best treat individuals with comorbid AD and PTSD. The use of an ... |
|
| A New Therapeutic Strategy for Autosomal Dominant Polycystic Kidney Disease: Activation of AMP Kinase by Metformin |
Jul 2011 |
23 pages |
| Authors:
Michael J Caplan; YALE UNIV NEW HAVEN CT
|
| Autosomal dominant polycystic kidney disease is a common inherited disorder. Patients are born with normal kidneys but, over the course of decades, they develop large fluid filled cysts that damage the normal kidney tissue. The damage caused by these cysts can lead ultimately to kidney failure, necessitating kidney transplantation or dialysis. There are currently no approved medications for this condition. Recent research reveals that the formation of cysts is due ... |
|
| Tunable Thermal Radiative Properties of Nanotube and Nanowire Arrays |
28 Jun 2011 |
34 pages |
| Authors:
Xiulin Ruan; Timothy Fisher; PURDUE UNIV LAFAYETTE IN
|
| A multiscale multiphysics simulation tool, by integrating excited state ab initio calculations and FDTD simulations, has been developed. It has the capability of predicting thermal radiative properties of nanotube/nanowire arrays given their atomic structures. Benchmark work is first performed on semiconductor GaAs to demonstrate the effectiveness of our approach, showing that both infrared and visible band radiative properties agree well with experimental data. Ab initio calculations on single walled carbon ... |
|
| A Psychophysiologic Study of Weakening Traumatic Combat Memories with Post-Reactivation Propranolol |
Jun 2011 |
16 pages |
| Authors:
Roger K Pitman; MASSACHUSETTS GENERAL HOSPITAL BOSTON
|
| Introduction: The eta-adrenergic blocker propranolol has been shown to reduce reconsolidation of aversive memories in rodents. Administration of propranolol following reactivation of traumatic memories in male and female civilians with PTSD has been shown to reduce physiological responses during subsequent mental imagery the traumatic event. Aims: The present study aimed to examine whether the fear-weakening effect of propranolol may be due to non-specific actions of the drug. Here we investigated ... |
|
| Spontaneous Buckling of Lipid Bilayer and Vesicle Budding Induced by Antimicrobial Peptide Magainin 2: A Coarse-Grained Simulation Study |
30 May 2011 |
9 pages |
| Authors:
Hyung-June Woo; Anders Wallqvist; ARMY MEDICAL RESEARCH AND MATERIEL COMMAND FORT DETRICK MD TELEMEDICINE AND ADVANCED TECH RESEARCH CENTER
|
| Molecular mechanisms of the action of antimicrobial peptides on bacterial membranes were studied by large scale coarse-grained simulations of magainin 2 dipalmitoylphosphatidylcholine/palmitoyloleoylphosphatidylglycerol (DPPC/POPG) mixed bilayer systems with spatial extents up to 0.1 micrometers containing up to 1600 peptides. Equilibrium simulations exhibit disordered toroidal pores stabilized by peptides. However, when a layer of peptides is placed near the lipid head groups on one side of the bilayer only, their incorporation leads ... |
|
| The Effect of Post Traumatic Stress Disorder on Military Leadership: An Historical Perspective |
19 MAY 2011 |
54 pages |
| Authors:
Karen A. Baker; ARMY COMMAND AND GENERAL STAFF COLL FORT LEAVENWORTH KS SCHOOL OF ADVANCED MILITARY STUDIES
|
| This monograph examines the effects of Post Traumatic Stress Disorder (PTSD) on military leadership. For over twenty years, the United States Army has used the Be, Know, Do leadership model to describe what Army leadership is and does. The BKD leadership model addresses the personal values, competence, and actions of a leader that influence others to achieve successful mission accomplishment. Ongoing operations demonstrated shortcomings in current doctrine, which are clarified ... |
|
| Unbalanced Stability: Applying Lessons from American Cities in Stability Operations |
19 MAY 2011 |
45 pages |
| Authors:
Ryan R. Poyant; ARMY COMMAND AND GENERAL STAFF COLL FORT LEAVENWORTH KS SCHOOL OF ADVANCED MILITARY STUDIES
|
| Over the past decade, the United States has focused its military energy on the conduct of Stability Operations. The U.S. Department of Defense raised Stability Operations to the same level of importance as Offensive and Defensive Operations in 2005. The U.S. government has worked to integrate other national government agencies, as well as partner host nation agencies, into Stability Operations. Many cities in the United States suffer from threats that ... |
|
| Chains of Metamaterials for Guiding and Antenna Applications |
Apr 2011 |
127 pages |
| Authors:
Andrea Alu; TEXAS UNIV AT AUSTIN DEPT OF ELECTRICAL AND COMPUTER ENGINEERING
|
| Final report contains results produced within the effort sponsored by the U.S. Air Force Research Laboratory with Contract No. FA8718-09-C-0061. Focus was on the most relevant aspects of our findings, which was fully addressed during the effort: guided propagation and leaky-wave radiation along linear arrays of nanoparticles, also considering and modeling the realistic presence of technological disorder, comparison of the guidance properties along linear and planar arrays of nanoparticles and ... |
|
| Genetics of Eosinophilic Esophagitis |
Mar 2011 |
33 pages |
| Authors:
Marc E Rothenberg; CHILDREN'S HOSPITAL MEDICAL CENTER CINCINNATI OH
|
| Eosinophilic esophagitis (EE) is an emerging worldwide food allergic disorder associated with polysensitization to multiple food allergens, resulting in greatly restricted diets and chronic gastroesophageal reflux disease-like symptoms in many individuals. EE has a strong genetic component based on the frequent presence of a familial inheritance pattern, the high sibling risk ratio (80-fold) and the demonstration that a single nucleotide polymorphism (SNP) in the eotaxin-3 gene confers disease susceptibility. In ... |
|
| Smokeless Tobacco use Related to Military Deployment, Cigarettes and Mental Health Symptoms in a Large, Prospective Cohort Study Among US Service Members |
Jan 2011 |
14 pages |
| Authors:
Eric D Hermes; Timothy S Wells; Besa Smith; Edward J Boyko; Gary G Gackstetter; Shannon C Miller; Tyler C Smith; YALE UNIV NEW HAVEN CT SCHOOL OF MEDICINE
|
| To characterize smokeless tobacco initiation and persistence in relation to deployment, combat, occupation smoking and mental health symptoms. Design Prospective cohort, utilizing self-reported survey data from the Millennium Cohort Study. Setting US military service members in all branches including active duty, reserve and National Guard. Participants Population-based sample of 45 272 participants completing both baseline (July 2001 - June 2003; n = 77 047) and follow-up (June 2004-January 2006; n ... |
|
| Virtual Patients for Virtual Sick Call Medical Training |
Nov 2010 |
15 pages |
| Authors:
Patrick G Kenny; Thomas D Parsons; Pat Garrity; UNIVERSITY OF SOUTHERN CALIFORNIA LOS ANGELES INST FOR CREATIVE TECHNOLOGIES
|
| Training military clinicians and physicians to treat Soldiers directly impacts their mental and physical health and may even affect their sw?vival. Developing skills such as: patient interviewing, interpersonal interaction and diagnosis can be difficult and is severely lacking in hands-ontraining due to the cost and availablllty of trained standardized patients. A solution to this problem is in using computer generated virtual patient avatars that exhibit the mental and physiologically accurate ... |
|
| Technical Operations Support III (TOPS III). Task Order 0061: Fundamental Theory Based Assessment of Thermoelectric Merit Factor for Heusler Alloys |
OCT 2010 |
29 pages |
| Authors:
Alper Kinaci; Shiv Meka; Cem Sevik; Tahir Cagin; TEXAS A AND M UNIV COLLEGE STATION
|
| Intensive previous work (1950-1970) led to discovery of bulk Bi2Te3 and Sb2Te3 type heavy metal, low temperature thermoelectrics having dimensionless figure of merits (ZT's) in the vicinity of 1. Nonetheless, no material having marginally higher performance over Bi-Te and Sb-Te thermoelectrics can yet be commercialized. Moreover, these materials are not very practical due to scarcity of the elements, toxicity and decomposition-evaporation problems at elevated temperatures. Today, there are a number ... |
|
| Deployment, PTSD Symptoms, and Co-morbid Mental Health Conditions in the Active Force and Reserve Components |
Oct 2010 |
125 pages |
| Authors:
Laurel Hourani; Marion Lane; Alyssa Mansfield; Robert Bray; Janice Brown; Caroline Reyes; RESEARCH TRIANGLE INST RESEARCH TRIANGLE PARK NC
|
| Posttraumatic stress disorder (PTSD) has been associated with comorbidity of many somatic and mental disorders. Such psychiatric comorbidity poses increased treatment challenges for a military population that already tends to underutilize treatment services. Further, the prevalence and pattern of these comorbidities within the total force are unknown. Although some of these comorbidities may be associated with combat-related traumas, others may be more associated with separate noncombat risk and protective factors ... |
|
| Medial Prefrontal Cortex and HPA Axis Roles in Generation of PTSD-Like Symptoms in SPS Model |
Sep 2010 |
26 pages |
| Authors:
Israel Liberzon; Dayan Knox; Sophie George; MICHIGAN UNIV ANN ARBOR
|
| In this report, we will demonstrate that we have a) replicated some pilot findings presented in the initial grant application, b) completed some of the proposed research in specific aims #2 and #3, and c) started research proposed in specific aim #4. We have been unable to replicate our initial SPS effect on social avoidance and freezing induced by trimethlylthiazoline (i.e. predator odor), but are still interested in exploring SPS ... |
|
| Combat-Related Posttraumatic Headache: Diagnosis, Mechanisms of Injury, and Challenges to Treatment |
Sep 2010 |
7 pages |
| Authors:
Matthew Kozminski; MADIGAN ARMY MEDICAL CENTER TACOMA WA
|
| Studies have revealed the rates of posttraumatic stress disorder (PTSD) and concussion among US soldiers returning from combat, but only one study has focused on the subpopulation of soldiers with headache. |
|
| Glutamate Transmission Enhancement for Treatment of PTSD |
Sep 2010 |
13 pages |
| Authors:
Victoria Risbrough; CALIFORNIA UNIV SAN DIEGO LA JOLLA
|
| Although now considered to be the most effective treatment for post traumatic stress disorder (PTSD), extinction based therapies require substantial time and investment for both the patient and provider, averaging 10 sessions or more of approximately 1h each to achieve significant beneficial effects. Thus, treatments that enhance the efficacy of extinction therapies and reduce the number of required sessions for remission would be of great benefit. Ideally, such adjunctive treatments ... |
|
| Epigenetic Regulation of the Autism Susceptibility Gene, ENGRAILED 2 (EN2) |
Jul 2010 |
8 pages |
| Authors:
James H Millonig; UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY PISCATAWAY
|
| Autism Spectrum Disorder (ASD) risk is likely due to both genetic susceptibility and non-genetic environmental factors. The environment can influence gene expression by epigenetic differences. Our previous research demonstrated the homeobox transcription factors, ENGRAILED 2 (EN2) is genetically associated with ASD. The ASD-associated variant is also functional, increasing levels both in vitro and in vivo. Human post-mortem studies also demonstrate increased EN2 levels. We then hypothesized that increased levels could ... |
|
| Fundamental Questions About Superconductivity in the Pnictides (Former title: Electromagnetic and Nanostructural Studies of Rare Earth Copper Oxide Grain Boundaries Grain Boundaries in High Temperature Superconductors) |
30 Jun 2010 |
7 pages |
| Authors:
David C Larbalestier; Alex Gurevich; FLORIDA STATE UNIV TALLAHASSEE
|
| In early 2008 the Hosono group at Tokyo Institute of Technology discovered high temperature superconductivity in a new extensive family of pnictides based on doped As-Fe. This exciting discovery encouraged us to transition our work on grain boundary studies of YBCO to this new class of superconductors. We showed that they indeed exhibit high critical temperatures Tc, extremely high upper critical fields Hc2, an irreversibility field H* close to Hc2, ... |
|
| Developing a Zebrafish Model of NF1 for Structure-Function Analysis and Identification of Modifier Genes |
Apr 2010 |
27 pages |
| Authors:
Jonathan A Epstein; PENNSYLVANIA UNIV PHILADELPHIA
|
| The primary goal of this project is to develop a zebrafish model of the autosomal dominant genetic disorder type I neurofibromatosis (NF1). This disorder is very common, affecting approximately 1 in 3000 live births, and results from mutations in the NF1 gene. A zebrafish model of this disease will be particularly useful in furthering our understanding of the pathophysiology of this disorder and will allow the application of high throughput ... |
|
| A FRET-Based Method for Probing the Conformational Behavior of an Intrinsically Disordered Repeat Domain from Bordetella pertussis Adenylate Cyclase |
22-Oct-2009 |
11 pages |
| Authors:
Geza R Szilvay; Mark A Blenner; Oren Shur; Donald M Cropek; Scott Banta; COLUMBIA UNIV NEW YORK DEPT OF CHEMICAL ENGINEERING
|
| A better understanding of the conformational changes exhibited by intrinsically disordered proteins is necessary as we continue to unravel their myriad biological functions. In repeats in toxin (RTX) domains, calcium binding triggers the natively unstructured domain to adopt a ? roll structure. Here we present an in vitro Foerster resonance energy transfer (FRET)-based method for the investigation of the conformational behavior of an RTX domain from the Bordetella pertussis adenylate ... |
|
| Importance of Virtual Reality to a Controlled Stimulus |
Oct 2009 |
6 pages |
| Authors:
Robert McLay; GENEVA FOUNDATION LAKEWOOD WA
|
| This study is a follow up to two projects, funded by the Office of Naval Research, which demonstrated that Virtual Reality Exposure Therapy was safe and effective for the treatment of Post Traumatic Stress Disorder in Service Members who served in Iraq or Afghanistan, and that it worked better than treatment as usual. In this study, we are attempting to discover if the Virtual Realty is actually the active component ... |
|
| Mortuary Affairs Soldiers: Early Intervention and Altering Barriers to Care for Traumatic Stress and PTSD |
SEP 2009 |
6 pages |
| Authors:
Carol S. Fullerton; HENRY M JACKSON FOUNDATION ROCKVILLE MD
|
| This project was designed to implement and assess the feasibility of a unique and newly developed intervention (TEAM: Troop Education for Army Morale: Units and Individuals Working Together). TEAM is designed to meet the specific post deployment needs of Mortuary Affairs (MA) Soldiers for early and follow-up intervention to speed recovery, return to work and limit barriers to care through individual training, active engagement in problem solving and accessing care, ... |
|
| Biochemical Characterisation of TSC1 and TSC2 Variants Identified in Patients with Tuberous Sclerosis Complex |
Jul-2009 |
74 pages |
| Authors:
Mark Nellist; ERASMUS MEDICAL CENTER ROTTERDAM (NETHERLANDS)
|
| The key findings of the project during the research period (23/1/09 - 31/7/09) are as follows: 1. Derivation and testing of 31 unclassified TSC2 variants: 16 classified as pathogenic; 7 classified as neutral; 8 still unclassified/analysis not complete. 2. Derivation of 12 unclassified TSC1 variants: 3 classified as pathogenic; 7 classified as neutral; 2 still unclassified/analysis not complete. 3. Improved assay cost, throughput and reproducibility. 4. Idenbtification of variants with ... |
|
| Compassion Fatigue in the Military Caregiver |
01-Mar-2009 |
32 pages |
| Authors:
Martha J Hayes; ARMY WAR COLL CARLISLE BARRACKS PA
|
| Compassion Fatigue (CF) is a critical problem with caregivers throughout the Military who work with combat survivors and their families. There is an urgent need for caregivers at all levels to recognize and receive proper education and/or intervention. This research paper will explore current interventions and process and propose, where applicable, alternative or additional programs, process or intervention to address compassion fatigue, burnout, stress disorder or other debilitating post-traumatic effects. ... |
|
| A Tale of Two Disability Coding Systems: The Veterans Administration Schedule for Rating Disabilities (VASRD) vs. Diagnostic Coding Using the International Classification of Diseases, 9th Edition, Clinical Modification (ICD-9-CM) |
JAN 2008 |
62 pages |
| Authors:
Nicole S. Bell; Ilyssa E. Hollander; Jeffrey O. Williams; Paul J. Amoroso; SOCIAL SECTORS DEVELOPMENT STRATEGIES INC BOSTON MA
|
| Disability rates have increased by approximately 10% per year over the past 25 years. Little is known about the etiology, in part because Veterans Administration Schedule for Rating Disabilities (VASRD) codes are not clinical diagnoses. This report describes results from analyses linking VASRD disability codes to International Classification of Disease, 9th Rev., Clinical Modification (ICD-9-CM) clinical diagnoses captured in hospital administrative records during disability case processing. Results suggest that while ... |
|
| Kyrgyzstan's Constitutional Crisis: Context and Implications for U.S. Interests |
05 JAN 2007 |
|
| Authors:
Jim Nichol; LIBRARY OF CONGRESS WASHINGTON DC CONGRESSIONAL RESEARCH SERVICE
|
 | This report examines civil disorder in Kyrgyzstan surrounding the enactment of a new constitution providing for greater balance between presidential and legislative powers. This report may be updated. |
|
| The Electronic Structure and Field Effects of an Organic-Based Room Temperature Magnetic Semiconductor |
01-Jan-2007 |
148 pages |
| Authors:
Derek M Lincoln; AIR FORCE INST OF TECH WRIGHT-PATTERSON AFB OH
|
| The future of spin-electronics or "spintronics" lies in the development of viable magnetic semiconductors that can effectively operate at room temperature Vanadium tetracyanoethylene (V[TCNE]~2) is a magnetic semiconductor with an ordering temperature well above that of room. Its highly disordered structure has hampered a comprehensive description of the interactions between the V and TCNE sublattices that give rise to its magnetic and electrical properties. We report the results of high-resolution ... |
|
| Morphology and Phase Transitions in Styrene-Butadiene-Styrene Triblock Copolymer Grafted with Isobutyl Substituted Polyhedral Oligomeric Silsesquioxanes (Postprint) |
2007 |
9 pages |
| Authors:
Daniel B. Drazowski; Andre Lee; Timothy S. Haddad; AIR FORCE RESEARCH LAB EDWARDS AFB CA SPACE AND MISSILE PROPULSION DIV
|
| Two symmetric triblock polystyrene-butadiene-polystyrene (SBS) copolymers with different styrene content were grafted with varying amounts of isobutyl-substituted polyhedral oligomeric silsesquioxane (POSS) molecules. The POSS octamers, R'R7Si8O12 were designed to contain a single silane functional group, R', which was used to graft onto the dangling 1,2 butadienes in the polybutadiene block and seven identical organic groups, R=isobutyl (iBu). Morphology and phase transitions of these iBu-POSS modified SBS were investigated using small ... |
|
| Activated Ras as a Direct Therapeutic Target for Neurofibromatosis Type 1: An Innovative Approach for Identifying Classes of Inhibitors |
DEC 2006 |
8 pages |
| Authors:
John Sondek; NORTH CAROLINA UNIV AT CHAPEL HILL
|
| Neurofibromatosis Type 1 (NF1) arises from the aberrant activation of Ras, a GTPases important controlling mitogenic potential. In an effort to control the aberrant activation of Ras to treat NF1 as well as other cancer, a high throughput screen was developed to screen for small molecule inhibitors of Ras activation by Sos1, a ubiquitous guanine nucleotide exchange factor that catalyzes the activation of Ras. Using this screen, several initial leads ... |
|
Reports by Keyword(s)
ORDER DISORDER TRANSFORMATIONS
