Tumor biology is a recognized determinant of tumor behavior, including growth rate, motility and metastatic potential, and therapeutic resistance. This project was funded to investigate the regulation and expression of an excellent marker for aggressive breast tumors: RhoC-GTPase. When overactive, RhoC transforms mammary epithelial cells into a highly motile and invasive phenotype. We hypothesize that RhoC overexpression may be regulated by the transcription factor NF-kappa B and that at the ...
Reports by Keyword(s)
MOTILITY
