| Diffusion Tensor Imaging and Its Application to Traumatic Brain Injury: Basic Principles and Recent Advances |
Dec 2012 |
27 pages |
| Authors:
Ping-Hong Yeh; Terrence R Oakes; Gerard Riedy; UNIFORMED SERVICES UNIV OF THE HEALTH SCIENCES BETHESDA MD
|
 | Traumatic axonal injury is a progressive process evoked by shear forces on the brain, gradually evolving from focal axonal alteration and cumulating in neural disconnection. Clinical classifiers and conventional neuroimaging are limited in traumatic axonal injury detection, outcome prediction, and treatment guidance. Diffusion weighted imaging is an advanced magnetic resonance imaging (MRI) technique that is sensitive to the movement of water molecules, providing additional information on the micro-structural arrangement of ... |
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| Pathophysiology of Post Amputation Pain |
11 Oct 2012 |
23 pages |
| Authors:
R N Harden; REHABILITATION INST OF CHICAGO IL
|
| This study is being done because post amputation pain (PAP) is common, yet very little is known about the causes of this pain. The purpose of this study is to see how PAP affects the body and brain by using sensory testing (such as pinprick testing), taking pictures of your brain (using a functional magnetic resonance imaging (fMRI) machine) and biomedical interventions (such as an injection of pain medicine). We ... |
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| Neuroperformance Imaging |
Oct 2012 |
47 pages |
| Authors:
Seong K Mun; Linda Larson-Prior; Kenneth Wong; Alpay Ozcan; VIRGINIA POLYTECHNIC INST AND STATE UNIV BLACKSBURG OFFICE OF SPONSORED PROGRAMS
|
| We have designed an appropriate PET imaging protocol that will allow us to differentiate regional metabolic activity between different sleep cycle periods. Pilot diffusion MRI data using phantoms has informed a new and more accurate mathematical model, CFD-MRI, for MR tractography. The analysis indicates the necessity of further investigations for better understanding and quantifying various artifacts in data collection. Using the simultaneous fMRI-EEG data techniques, brain regions of interest and ... |
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| Quantitative Tractography and Volumetric MRI in Blast and Blunt Force TBI: Predictors of Neurocognitive and Behavioral Outcome |
Oct 2012 |
80 pages |
| Authors:
Lisa Delano-Wood; VETERANS MEDICAL RESEARCH FOUNDATION (VETERANS AFFAIRS) SAN DIEGO CA
|
| The major goals and aims of this study are to investigate whether differences in cognitive outcome are related to mechanism of injury as well as white matter integrity using diffusion tensor imaging (DTI). We are also collecting and analyzing data in order to determine whether MR variables of interest are associated with psychosocial/clinical outcome, and whether there are group differences by mechanism of injury. Specifically, in the context of this ... |
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| Magnetic Resonance Characterization of Axonal Response to Spinal Cord Injury |
Oct 2012 |
14 pages |
| Authors:
Felix W Wehrli; PENNSYLVANIA UNIV PHILADELPHIA
|
| Assessment of axon health in spinal cord injury (SCI) is vital for proper diagnosis and treatment. Magnetic resonance imaging (MRI) is routinely performed in patients and provides valuable information about cord edema and hemorrhage. However, comprehensive prediction of axonal changes from in vivo MR imaging remains elusive. At the U. Penn site, we are applying two novel MRI methods to the problem of assessment of axonal loss, axonal diameter distribution, ... |
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| Improving the Efficiency and Efficacy of Glibenclamide in Limiting Progressive Hemorrhagic Necrosis Following Traumatic Spinal Cord Injury |
Oct 2012 |
5 pages |
| Authors:
J M Simard; BALTIMORE UNIV MD
|
| Preclinical work has demonstrated that glibenclamide administration improves outcomes in rat models of spinal cord injury, with the principal mechanism of action being amelioration of post-traumatic hemorrhagic necrosis (PHN). We hypothesize that some but not all patients with spinal cord injury, principally those with incomplete lesions, will respond to glibenclamide therapy. Our goal is identify early markers of injury that can be used to predict which patients may benefit from ... |
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| Advanced Pediatric Brain Imaging Research and Training Program |
Oct 2012 |
36 pages |
| Authors:
Catherine Limperopoulos; CHILDREN'S HOSPITAL WASHINGTON DC
|
| Brain injury is a leading cause of death and disability in children. Recent advances in pediatric magnetic resonance imaging (MRI) techniques are revolutionizing our understanding of brain injury, its potential for recovery, and demonstrating enormous potential for advancing the field of neuroprotection. We have created a highly structured, collaborative, and multidisciplinary training program in BRAIN (Brain Research Advanced Imaging with NMR) to advance research skills of investigators from all branches ... |
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| Multimodal Imaging of Pathophysiological Changes and Their Role in Development of Breast Cancer Brain Metastasis |
01 Sep 2012 |
18 pages |
| Authors:
Dawen Zhao; TEXAS UNIV AT DALLAS SOUTHWESTERN MEDICAL CENTER
|
| Brain metastasis represents a poor prognosis and is frequently the cause of death in breast cancer patients. Tumor microcirculation and oxygenation play important roles in malignant progression and metastasis, as well as response to various therapies. Understanding of hypoxia development and its relationship with blood brain barrier (BBB) during intracranial tumor growth will be crucial for clinical management of breast cancer brain metastasis. We have developed a MRI approach based ... |
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| Imaging Effects of Neurotrophic Factor Genes on Brain Plasticity and Repair in Multiple Sclerosis |
Jul 2012 |
10 pages |
| Authors:
Heather Wishart; DARTMOUTH COLL HANOVER NH
|
| The aim of this study is to develop a better biomarker for multiple sclerosis (MS) by combining genotype and imaging data. Patient with MS undergo evaluation to confirm diagnosis and determine disability level. They have blood drawn for genotyping, and undergo magnetic resonance imaging (MRI) sensitive to focal and diffuse changes in brain tissue (including cortical thickness and subcortical volume measures, lesion volumetry, and voxel-based morphometry and diffusion imaging). We ... |
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| Database Development for Ocean Impacts: Imaging, Outreach and Rapid Response |
18 Apr 2012 |
10 pages |
| Authors:
D R Ketten; WOODS HOLE OCEANOGRAPHIC INSTITUTION MA
|
| At present, there are substantial concerns about the impacts of anthropogenic sound in the oceans, and there is a particular focus by the public on impacts from military sonars which is having a substantial practical and fiscal impact on US Navy operations. Multiple research approaches are being employed to address the question of the possible extent and mechanisms for acoustic impacts, but progress has been slow. In part this is ... |
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| Biocompatible, Biodegradable, and Enzymatic-Cleavable MRI Contrast Agents for Early Detection of Bone Metastatic Breast Cancer |
Apr 2012 |
9 pages |
| Authors:
Xuli Wang; UTAH UNIV SALT LAKE CITY
|
| This project proposes to design and test a novel peptide-based MRI contrast agent for early detection of bone metastasis from breast cancer. The proposed imaging agent is consist of bone targeting moiety of Asp8 and MRI imaging moiety of DOTA(Gd) with a cathepsin K cleavable peptide spacer. A solid phase peptide synthesis (SPPS) strategy was used to synthesize peptides. Coupling of the peptide onto DOTA followed by Gd complexation was ... |
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| WAVE3 is a Biomarker for Breast Cancer Progression and Metastasis |
Apr 2012 |
78 pages |
| Authors:
Khalid Sossey-Alaoui; CLEVELAND CLINIC FOUNDATION OH
|
| About one-third of patients with cancer have metastases that are detected at the time their cancer is first diagnosed, and an additional third of patients have metastases that are too small to be detected by usual diagnostic tests. These micrometastases, however, will eventually grow into clinically significant metastases if the patient receives no treatment or local treatment of the primary tumor only. Metastatic breast cancer is a disease with low ... |
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| Agents Within our Midst |
14 Mar 2012 |
16 pages |
| Authors:
Michael Goger; NEW YORK STRUCTURAL BIOLOGY CENTER INC NEW YORK NY
|
| The New York Structural Biology Center (NYSBC), a leading center in magnetic resonance spectroscopy and X-ray crystallography, has worked with researchers at Albert Einstein College of Medicine (AECOM), and scientists at the Edgewood Chemical Biological Center (ECBC) in several projects whose objective is the analysis of the chemical and biological makeup of warfare agents. The projects include: the structural analysis of Staphylococcal Enterotoxin B (SEB), considered to be a potential ... |
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| Early Breast Lesion Typing With Hyperpolarized Choline, Benign Or Malignant |
Feb 2012 |
8 pages |
| Authors:
Shawn Wagner; CEDARS-SINAI MEDICAL CENTER LOS ANGELES CA
|
| This work is focused on developing a breast cancer biomarker utilizing magnetic resonance spectroscopy/imaging and hyperpolarization. I have initiated and completed most of the elements in the first part of the project which consist of developing the equipment and the biomarker agent. Task 2-4 required the completion of Task 1. The most significant achievement is the completion of the required equipment and initial testing. We have developed a fully functional ... |
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| New Methods of Low-Field Magnetic Resonance Imaging for Application to Traumatic Brain Injury |
Feb 2012 |
24 pages |
| Authors:
Matthew Rosen; HARVARD COLL CAMBRIDGE MA
|
| We have been developing robust low-magnetic-field implementations of MRI (LFI) focused on brain imaging. In particular we have expanded our development of the LFI test bed to include two complimentary approaches: electromagnet and permanent magnet based test bed scanner systems. We are also developing injury-sensitive MRI based on converting the electron spin of free radicals associated with injury into nuclear polarization using the Overhauser effect and subsequently imaging that modified ... |
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| Effects of Bright Light Therapy of Sleep, Cognition, Brain Function, and Neurochemistry in Mild Traumatic Brain Injury |
Jan 2012 |
128 pages |
| Authors:
William Killgore; MCLEAN HOSPITAL BELMONT MA
|
| Data collection is currently underway and preliminary findings from the first subjects to complete the study are encouraging. Overall, our preliminary data on cognition, emotion, subjective and objective sleep quality suggest that six weeks of morning Bright Blue Light therapy versus comparable Amber Light Placebo are supporting our initial hypotheses. Furthermore, initial comparisons using functional magnetic resonance imaging tasks also suggest that the Bright Blue Light condition was effective in ... |
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| Improvements in Diagnostic Accuracy with Quantitative Dynamic Contrast-Enhanced MRI |
Dec 2011 |
13 pages |
| Authors:
Federico Pineda; CHICAGO UNIV IL
|
| We developed novel calibration phantoms that when placed in a breast coil during a routine dynamic contrast enhanced MRI of the breast allow for the acquisition of quantitative images displaying the concentration of contrast media as well as MRI-detectable proton density. To date 21 patients have been scanned with the phantoms. Preliminary results suggest a differentiation between benign and malignant lesion by peak concentration of contrast media. A study is ... |
|
| Magnetic Resonance Characterization of Axonal Response to Spinal Cord Injury |
Oct 2011 |
7 pages |
| Authors:
Felix W Wehrli; PENNSYLVANIA UNIV PHILADELPHIA
|
| Assessment of axon health in spinal cord injury (SCI) is vital for proper diagnosis and treatment. Magnetic resonance imaging (MRI) is routinely performed in patients and provides valuable information about cord edema and hemorrhage. However, comprehensive prediction of axonal changes from in vivo MR imaging remains elusive. At the U. Penn site, we are applying two novel MRI methods to the problem of assessment of axonal loss, axonal diameter distribution, ... |
|
| Neuromimaging of Brain Injuries and Disorders at Cleveland Clinic |
Oct 2011 |
7 pages |
| Authors:
Stephen Rao; CLEVELAND CLINIC FOUNDATION OH
|
| Blast injuries are the leading cause of injury in the Afghanistan and Iraq wars. It is unknown whether the neural and cognitive sequelae of blast-related traumatic brain injury (TBI) differs from those resulting from mechanically-induced TBI commonly observed in civilian accidents. Understanding the potentially unique sequelae of blast-related TBI is critical for accurate diagnosis and designing effective pharmacological and neurorehabilitation interventions. Functional MRI is an imaging method that detects increases ... |
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| Improving the Efficiency and Efficacy of Glibenclamide in Limiting Progressive Hemorrhagic Necrosis Following Traumatic Spinal Cord Injury |
Oct 2011 |
6 pages |
| Authors:
J M Simard; MARYLAND UNIV BALTIMORE
|
| Preclinical work has demonstrated that glibenclamide administration improves outcomes in rat models of spinal cord injury, with the principal mechanism of action being amelioration of post-traumatic hemorrhagic necrosis (PHN). We hypothesize that some but not all patients with spinal cord injury, principally those with incomplete lesions, will respond to glibenclamide therapy. Our goal is identify early markers of injury that can be used to predict which patients may benefit from ... |
|
| Value of MRI and DTI as Biomarkers for Classifying Acute Spinal Cord Injury |
Oct 2011 |
12 pages |
| Authors:
Adam E Flanders; THOMAS JEFFERSON UNIV PHILADELPHIA PA
|
| The purpose of this study is to determine if diffusion tensor imaging (DTI) in conjunction with conventional magnetic resonance imaging (MRI) can reliably forecast neurologic recovery after spinal cord injury (SCI). As we are only in our second month of patient recruitment, there are no significant findings to report. |
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| Hierarchical Topological Network Analysis of Anatomical Human Brain Connectivity and Differences Related to Sex and Kinship |
Oct 2011 |
121 pages |
| Authors:
Julio M Duarte-Carvajalino; Neda Jahanshad; Christophe Lenglet; Katie L McMahan; Greig I de Zubicacy; Nicholas G Martin; Margaret J Wright; Paul M Thompson; Guillermo Sapiro; MINNESOTA UNIV MINNEAPOLIS INST FOR MATHEMATICS AND ITS APPLICATIONS
|
| Modern non-invasive brain imaging technologies, such as diffusion weighted magnetic resonance imaging (DWI), enable the mapping of neural fiber tracts in the white matter, providing a basis to reconstruct a detailed map of brain structural connectivity networks. Brain connectivity networks differ from random networks in their topology, which can be measured using small worldness, modularity, and high-degree nodes (hubs). Still, little is known about how individual differences in structural brain ... |
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| Magnetic Resonance Characterization of Axonal Response to Spinal Cord Injury |
Oct 2011 |
29 pages |
| Authors:
David Hackney; BETH ISRAEL DEACONESS MEDICAL CENTER BOSTON MA
|
| During the first year we pursued studies of q-space imaging (QSI) of the spinal cord and myelin imaging. The QSI studies extended our previous work establishing our ability to define the distribution of axon fiber diameters using this noninvasive approach. This work was presented at the Annual Meeting of the International Society of Magnetic Resonance in Medicine in Montreal, May, 2011. In addition, we made great progress with an ultra-short ... |
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| Voxel-Wise Time-Series Analysis of Quantitative MRI in Relapsing-Remitting MS: Dynamic Imaging Metrics of Disease Activity Including Pre-Lesional Changes |
Oct 2011 |
9 pages |
| Authors:
Aaron S Field; WISCONSIN UNIV MADISON
|
| Previous MRI studies in MS have retrospectively analyzed normal-appearing brain tissue in locations where typical MS lesions ultimately appeared, finding pre-lesional changes in several MRI metrics. However, studies have not been entirely consistent and the development of a prototypical MS lesion cannot as yet be prospectively predicted. The primary objective of this project is to validate the preactive lesion hypothesis in MS by identifying the spatiotemporal imaging signature of white ... |
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| A Novel Multi-voxel Based Quantitation of Metabolites and Lipids Non-invasively Combined with Diffusion Weighted Imaging in Breast Cancer |
Sep 2011 |
13 pages |
| Authors:
Michael A Thomas; CALIFORNIA UNIV LOS ANGELES
|
| Purpose: (1) To extend the single-voxel based 2D MRS version of L-COSY to multi-voxel based analogue on a 3T MRI/MRS scanner using the echo-planar imaging (EPI) based spatial encoding for determining metabolic distributions over many voxels; (2) To implement a Matlab-based post-processing algorithm in order to process the 2D COSY data recorded in breast cancer; (3) To record DWI and to calculate ADC maps in breast cancer patients and healthy ... |
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| Advanced MRI in Acute Military TBI |
Sep 2011 |
7 pages |
| Authors:
David Brody; WASHINGTON UNIV ST LOUIS MO
|
| The objective of this project is to test two advanced Magnetic Resonance Imaging (MRI) methods, Diffusion Tensor Imaging (DTI) and resting-state Functional Magnetic Resonance Imaging (fMRI), in military Traumatic Brain Injury (TBI) patients acutely after injury, and to correlate the findings with TBI-related clinical outcomes 6-12 months later. An additional objective is to test the interaction of candidate genetic vulnerability factors with patterns of injury. These combined methods may add ... |
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| Neural and Behavioral Sequelae of Blast-Related Traumatic Brain Injury |
Sep 2011 |
6 pages |
| Authors:
Stephen M Rao; CLEVELAND CLINIC FOUNDATION OH
|
| Traumatic brain injuries (TBI) are a common occurrence from roadside blasts of improvised explosive devices (IEDs). In the proposed cross-sectional study, we aim to apply neurobehavioral testing and advanced MRI techniques [task-activated functional MRI (fMRI) and diffusion tensor imaging (DTI)] to gain a comprehensive understanding of the neural changes underlying blast-related MTBI. We will accomplish this goal by conducting advanced neuroimaging (task-activated fMRI and DTI fiber tracking) and neurobehavioral testing ... |
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| Development and Validation of an fMRI Pain Metric for MS |
Sep 2011 |
6 pages |
| Authors:
Heather Wishart; DARTMOUTH COLL HANOVER NH
|
| Background and Significance. Pain is common in multiple sclerosis (MS) but is currently under-recognized and under-treated due in part to the absence of adequate metrics. The specific aims of this study are: (1) To create an fMRI pain metric designed specifically for individuals with MS that uses the minimum level of somatosensory stimulation necessary to elicit increased activation of thalamus, cingulate, insula, and sensorimotor cortex ( augmented central pain processing ... |
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| Development of an MRI-Guided Intra-Prostatic Needle Placement System |
Jul 2011 |
60 pages |
| Authors:
Gregory S Fischer; WORCESTER POLYTECHNIC INST MA
|
| Magnetic Resonance Imaging (MRI) is an ideal interventional guidance modality: it provides near real-time high-resolution images at arbitrary orientations and is able to monitor therapeutic agents, surgical tools, biomechanical tissue properties, and physiological function. MRI poses formidable engineering challenges by severely limited access to the patient and high magnetic field that prevents the use of conventional materials and electronic equipment. The objective is to make conventional diagnostic closed high-field MRI ... |
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| Photonic Breast Tomography and Tumor Aggressiveness Assessment |
Jul 2011 |
78 pages |
| Authors:
Swapan K Gayen; J A Koutcher; X Ni; M Alrubaiee; Binlin Wu; CITY UNIV OF NEW YORK RESEARCH FOUNDATION
|
| The tasks performed and the progresses made during the fourth year include: (a) carrying out research on development of non-invasive near-infrared (NIR) diffuse optical imaging (DOI) approaches for detection of breast tumors in early stages of growth when those are more amenable to treatment; and (b) training of CCNY researchers at MSKCC in magnetic resonance spectroscopic imaging (MRSI) for detectionof lactate in tumors. The NIR optical imaging research involved: (i) ... |
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| Targeting MRS-Defined Dominant Intraprostatic Lesions with Inverse-Planned High Dose Rate Brachytherapy |
JUN 2011 |
18 pages |
| Authors:
Jean Pouliot; CALIFORNIA UNIV SAN FRANCISCO
|
| A combination of MRI/MRSI is used to define the distribution of Dominant Intraprostatic Lesions (DIL) within the prostate. This information is used to perform dose escalation of the DIL without compromising the dose coverage of the prostate and the protection to the urethra, rectum, and bladder for prostate cancer patients treated with High Dose Rate (HDR) brachytherapy. The multi-image fusion process has been presented at national meetings during this period. ... |
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| Neuroprotective Strategies after Repetitive Mild Traumatic Brain Injury |
Jun 2011 |
120 pages |
| Authors:
Andre Obenaus; LOMA LINDA UNIV CA
|
| To explore two new neuroprotective strategies in the setting of experimental repetitive mild traumatic brain injury (mTBI): i) hyperbaric oxygen (HBO) preconditioning and ii) HBO treatment combined with intranasal delivery of nicotinamide (NAD). Scope: In rat model of a repetitive mild cortical controlled injury, we investigated the neuropathological profile of two mTBI sessions at two interval times (3, 7d) using non-invasive MRI assessments (T2WI, SWI, and DTI), correlated with histology. ... |
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| WAVE3 Is a Biomarker for Breast Cancer Progression And Metastasis |
APR 2011 |
27 pages |
| Authors:
Khalid Sossey-Alaoui; CLEVELAND CLINIC FOUNDATION OH
|
| About one-third of patients with cancer have metastases that are detected at the time their cancer is first diagnosed, and an additional third of patients have metastases that are too small to be detected by usual diagnostic tests. These micrometastases, however, will eventually grow into clinically significant metastases if the patient receives no treatment or local treatment of the primary tumor only. Metastatic breast cancer is a disease with low ... |
|
| Improved Assessments of Breast Cancer Therapies with DCE-MRI |
APR 2011 |
10 pages |
| Authors:
Julio C. Cardenas; ARIZONA UNIV TUCSON
|
| 14. ABSTRACT Dynamic Contrast Enhancement MRI (DCE MRI) has been used in clinical and pre-clinical trials of anti-angiogenic breast cancer therapies, but its high variability severely reduces the value of this imaging modality to asses the early response to anti-angiogenic therapies in an individual patient. Since the start of this grant we have developed a new pharmacokinetic model for DCE-MRI that removes the effect of hematocrit and blood flow on ... |
|
| Cortical-Cortical Interactions and Sensory Information Processing in Autism |
Apr 2011 |
33 pages |
| Authors:
Mark Tommerdahl; NORTH CAROLINA UNIV AT CHAPEL HILL
|
| There are two specific aims or categories of deliverables to be accomplished as tasks in this DoD sponsored research: The first specific aim is the hardware design and fabrication of a portable tactile diagnostic stimulator that can be used for the assessment of the cerebral cortical health of neurologically compromised subjects in particular, those subjects with autism. The second specific aim is the development of tactile discriminative protocols that will ... |
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| An fMRI Study of TBI Associated with Blast Injury |
Mar 2011 |
6 pages |
| Authors:
Richard M McCarron; NAVAL MEDICAL RESEARCH CENTER SILVER SPRING MD
|
| Using fMRI, we are conducting an observational study to characterize the pattern of brain activation during performance of cognitive control and working memory tasks in service personnel with mild traumatic brain injury (TBI) and severe TBI imaged between 3 and 42 months after injury. To date, 447 patients with TBI at Walter Reed Army Medical Center (WRAMC) have been screened. Thirteen patients diagnosed with TBI resulting from blast have met ... |
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| Cortical Mechanisms of Multi-step Action Planning |
16 DEC 2010 |
12 pages |
| Authors:
Scott H. Frey; OREGON UNIV EUGENE RESEARCH SERVICES AND ADMINISTRATION
|
| Our project seeks to understand the changes in behavior and brain that accompany the development of expertise in the telecontrol of tools and devices. Particular emphasis is placed on the control of multi-step actions in which ongoing behavior must be adjusted in anticipation of forthcoming task demands. These anticipatory adjustments to behavior reflect the use of internal representations. We are using functional magnetic resonance imaging (fMRI) and behavioral measures (kinematics) ... |
|
| Prostate Cancer Evaluation: Design, Synthesis and Evaluation of Novel Enzyme-Activated Proton MRI Contrast Agents |
OCT 2010 |
31 pages |
| Authors:
Jian-Xin Yu; TEXAS UNIV SOUTHWESTERN MEDICAL SCHOOL AT DALLAS
|
| The lacZ gene encoding E. coli beta-gal has already been recognized as the most commonly used reporter system in cancer gene therapy. Moreover, prostate-specific membrane antigen (PSMA) has been identified as an ideal antigenic target in prostate cancer. We propose to develop a novel class of Gd(III)-based MRI contrast agents for in vivo detection of beta-gal or PSMA activity. This new concept of the Gd(III)-based MRI contrast agents is composed ... |
|
| Regularized Reconstruction of Dynamic Contrast-Enhanced MR Images for Evaluation of Breast Lesions |
SEP 2010 |
15 pages |
| Authors:
Kimberly A. Khalsa; Jeffery A. Fessler; MICHIGAN UNIV ANN ARBOR
|
| The overall goal of this project is to develop, implement, and evaluate methods for improving image quality in dynamic MR imaging. We focus specifically on dynamic contrast-enhanced (DCE) imaging of breast cancer patients. We explore reconstruction methods that use explicit temporal models in object space. Simulation and phantom studies have indicated that our algorithms produce quality reconstructed image sequences that exhibit both high spatial and high temporal resolution. |
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| Advanced MRI In Blast-Related TBI |
Sep 2010 |
11 pages |
| Authors:
David L Brody; WASHINGTON UNIV ST LOUIS MO
|
| The purpose of the research effort is to test two advanced MRI methods, DTI and resting-state fMRI, in active-duty military blast-related TBI patients acutely after injury and correlate findings with TBI-related clinical outcomes 6-12 months later. These methods may add clinically useful predictive information following traumatic brain injury that could be of assistance in standardizing diagnostic criteria for TBI, making return-to-duty triage decisions, guiding post-injury rehabilitation, and developing novel therapeutics. ... |
|
| Advanced MRI Techniques to Assess Sleep Deprivation Vulnerability among Soldiers and Potentially Enhance Performance with Real-Time Biofeedback |
Oct 2009 |
15 pages |
| Authors:
Hunter Downs; Kevin A Johnson; John Carney; John Caldwell; Mark S George; ARCHINOETICS HONOLULU HI
|
| NATO needs better methods of measuring and predicting human performance, as well as novel methods of training soldiers that might enhance performance. New breakthroughs with magnetic resonance imaging (MRI) show promise in both areas. Rationale: Our group initially and now at least three others, have demonstrated that a baseline fMRI scan while subjects are performing a task can predict who will respond poorly or well after sleep deprivation (SD). That ... |
|
| Non-Invasive Nanodiagnostics of Cancer (NINOC) |
Jun-2009 |
17 pages |
| Authors:
Alexander Kabanov; NEBRASKA UNIV MEDICAL CENTER OMAHA
|
| This project seeks to develop noninvasive diagnostics to detect cancer in its earliest, most easily treatable, pre-symptomatic stage. Innovative imaging nanomaterials and delivery technologies are employed to target, label, and detect the cancer cells within the body at sites which are normally inaccessible to conventional diagnostic methods. The hydrophilic polymer nanogels of core-shell emission computed tomography, computer tomography, magnetic resonance, or luminescence detection. The surface of the nanogels is modified ... |
|
| Manganese Research Health Project (MHRP) |
Feb-2009 |
146 pages |
| Authors:
Michael Aschner; Vanesssa A Fitsanakis; VANDERBILT UNIV NASHVILLE TN
|
| Manganese (Mn) and iron are essential metals for normal growth and development that compete for and share the same transporters. Thus, during periods of low dietary iron intake, the transport and deposition of Mn in the brain are increased. Conversely, high-risk populations for Mn intoxication, namely Mn miners and welders, may benefit from iron supplementation, which may lower their central nervous system (CNS) Mn burden. For the first 3 years, ... |
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| An Investigation of Individual Variability in Brain Activity During Episodic Encoding and Retrieval |
Dec-2008 |
8 pages |
| Authors:
C L Donovan; M B Miller; CALIFORNIA UNIV SANTA BARBARA DEPT OF PSYCHOLOGY
|
| The purpose of this study was to test the reliability of self-reported strategy measures for predicting differences in brain activity patterns during a learning and memory task and to compare their predictive value to other measures of cognitive processing and of anatomy. Fifty participants were scanned with functional MRI (fMRI) while they intentionally encoded lists of lowly imageable words and completed subsequent recognition memory tests. After scanning, subjects were asked ... |
|
| Integration of Diagnostic and Interventional MRI for the Study of Persistent Prostate Cancer After External Beam Radiotherapy |
01-Oct-2008 |
9 pages |
| Authors:
Cynthia Menard; UNIVERSITY HEALTH NETWORK TORONTO (ONTARIO)
|
| This study involves the technical development and clinical testing of a novel technique for magnetic resonance imaging (MRI) guided prostate biopsy in a 1.5T horizontal bore scanner using a dedicated interventional table. We primarily hypothesize that the integration of diagnostic and interventional MRI enables needle biopsy targeting to foci of tumor recurrence after radiotherapy, and will enable a determination of the diagnostic accuracy of MRI in mapping sub-sites of tumor ... |
|
| Nanovectors for Targeting and Delivery of Therapeutics to HER-2 NEU Positive Breast Cancer Cells |
Oct-2008 |
25 pages |
| Authors:
Rita E Serda; TEXAS UNIV HEALTH SCIENCE CENTER AT HOUSTON
|
| Nanofabricated devices designed to carry drug and contrast agents to breast cancer cells are surface modified with targeting moieties that recognize unique or abundantly expressed molecules on the surface of tumor cells. However, major obstacles such as enzymatic degradation, uptake by professional phagocytes and the reticular endothelial system, and the vascular endothelium could hinder the ability of nanoparticles to reach the tumor site. To overcome these biological barriers, we have ... |
|
| 5th Annual World Congress of IBMISPS on Brain Mapping & Image Guided Therapy held at The University of California, Los Angeles on 26-29 August 2008 |
Oct-2008 |
75 pages |
| Authors:
Babak Kateb; INTERNATIONAL BRAIN MAPPING AND ISP SOCIETY WEST HOLLYWOOD CA
|
| The third (sic) annual meeting of International Brain Mapping & Intra-operative Surgical Planning Society (IBMISPS) was held at UCLA-California Nano-System Institute (CNSI). IBMISPS is a non-profit society organized for the purpose of encouraging basic and clinical scientists who are interested in areas of Brain Mapping and Intraoperative Surgical planning to improve the diagnosis, treatment and rehabilitation of patients afflicted with neurological disorders. Currently, there is no combined conference on both ... |
|
| Prostate Cancer Evaluation: Design, Synthesis and Evaluation of Novel Enzyme-Activated Proton MRI Contrast Agents |
Oct-2008 |
22 pages |
| Authors:
Jian-Xin Yu; TEXAS UNIV SOUTHWESTERN MEDICAL SCHOOL AT DALLAS
|
| The lacZ gene encoding E. coli beta-gal has already been recognized as the most commonly used reporter system in cancer gene therapy. Moreover, prostate-specific membrane antigen (PSMA) has been identified as an ideal antigenic target in prostate cancer. We propose to develop a novel class of Gd(III)-based MRI contrast agents for in vivo detection of beta-gal or PSMA activity. This new concept of the Gd(III)-based MRI contrast agents is composed ... |
|
| Molecular MR Imaging of Protease Activity in Breast Cancer with Activated Contrast Agents |
Oct-2008 |
7 pages |
| Authors:
Dmitri Artemov; Yoshinori Kato; JOHNS HOPKINS UNIV BALTIMORE MD SCHOOL OF MEDICINE
|
| We synthesized and characterized a smart MR contrast agent activated by Cathepsin-D enzyme. The agent was tested in a cell free system and in vitro with immobilized breast cancer cells. We also initiated animal studies however due to the finding that the structure of the probe needs to be optimized we are currently refining the agent for in vivo applications. |
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| Development of Convergence Nanoparticles for Multi-Modal Bio-Medical Imaging |
18-Sep-2008 |
18 pages |
| Authors:
Jinwoo Cheon; YONSEI UNIV SEOUL (KOREA SOUTH) DEPT OF CHEMISTRY
|
| The purpose of this project is to develop a novel, highly versatile, multi-functional convergence nanoparticle system for their advanced biomedical applications. Inorganic nanoparticles are now emerging as a promising candidate to revolutionize current science and technology. By utilizing inorganic nanoparticles, it is possible to have the ability to control physical/chemical properties of materials as we desire, which is not allowed in current technology. Furthermore, these inorganic nanoparticles exhibit improved physical/chemical ... |
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Reports by Keyword(s)
MAGNETIC RESONANCE IMAGING
