| Quantifying, Predicting, and Exploiting Uncertainty (QPE) |
19 Nov 2012 |
8 pages |
| Authors:
James F Lynch; WOODS HOLE OCEANOGRAPHIC INSTITUTION MA
|
 | LONG TERM GOALS. The long term goal of our QPE work is to: 1) quantitatively understand what the uncertainties are in low frequency (10-1500 Hz) acoustic propagation and noise that are caused by variable and complex oceanography and seabed structure, 2) determine the limits to predicting the fluctuating and variable propagation and noise in this frequency regime and others, and 3) ascertain what naval advantage may be gained (if any) ... |
|
| Human Capital: DOD Needs Complete Assessments to Improve Future Civilian Strategic Workforce Plans |
Sep 2012 |
50 pages |
| Authors:
GOVERNMENT ACCOUNTABILITY OFFICE WASHINGTON DC
|
| As of June 2012, the Department of Defense (DoD) reported a full-time civilian workforce of about 780,000 personnel. According to DoD, about 30 percent of its civilian workforce and 60 percent of its civilian senior leaders will be eligible to retire by March 31, 2015. Such potential loss may result in significant skill gaps. The National Defense Authorization Act for Fiscal Year 2010 requires GAO to submit a report on ... |
|
| A Bosque Riparian Community Index Model for the Middle Rio Grande, Albuquerque, New Mexico: Model Documentation |
Sep 2012 |
173 pages |
| Authors:
Kelly A Burks-Copes; Antisa C Webb; ENGINEER RESEARCH AND DEVELOPMENT CENTER VICKSBURG MS ENVIRONMENTAL LAB
|
| Over the last century, the Middle Rio Grande was subjected to significant anthropogenic pressures producing a highly degraded ecosystem that today is poised on the brink of collapse. In 2002, the U.S. Army Corps of Engineers (USACE) (Albuquerque District) was authorized to study the river and prepare an Environmental Assessment (EA), as required under the tenets of the National Environmental Policy Act (NEPA), to evaluate the effects of proposed ecosystem ... |
|
| A Technical Feasibility Study of a Green Area |
Sep 2012 |
101 pages |
| Authors:
Spyridon T Lamprou; NAVAL POSTGRADUATE SCHOOL MONTEREY CA
|
| A feasibility study of the creation of a community (either on or off grid), whose energy needs are fully covered by renewable energy sources, is a complicated task. The study may suggest and lead to policy and actions to minimize of even eliminate energy losses, and can guide us to zero emission cities and naval bases. This has the benefits of assisting ecology and petroleum-based fuel economy. During this study, ... |
|
| Design and Performance Evaluation of a 200 deg C Interleaved Boost Converter (Preprint) |
Sep 2012 |
22 pages |
| Authors:
James D Scofield; Seana A McNeal; Brett A Jordan; Hiroyuki Kosai; Biswajit Ray; AIR FORCE RESEARCH LAB WRIGHT-PATTERSON AFB OH AEROSPACE SYSTEMS DIR
|
| Recent advances in SiC power semiconductor technology and resulting availability of SiC Schottky rectifiers and controlled devices (BJTs, JFETs, and MOSFETs) make it possible to design and implement power converters capable of operating at 200oC. The design, prototype development, operation, and testing of a 74 kHz, 2 kW, 100 V/270 V inversely-coupled, interleaved, dc-dc boost converter over the 20oC to 200oC temperature range is presented in this paper. The advantages ... |
|
| Sealing Penetrating Eye Injuries with Photoactivated Bonding |
Sep 2012 |
24 pages |
| Authors:
Irene E Kochevar; MASSACHUSETTS GENERAL HOSPITAL BOSTON
|
| The purpose of this report is to develop a light-activated technology (called PTB) with the potential to decrease vision loss and ocular complications in warfighters sustaining penetrating eye injuries. Scope: To compare light-activated bonding of amnion to direct sealing of penetrating cornea wounds, to evaluate photobonding for puncture wounds in sclera, and to evaluate safety of photobonding to the iris. Major findings: Identified the treatment parameters for rapidly and strongly ... |
|
| Prevention and Treatment of Noise-Induced Tinnitus |
Jul 2012 |
10 pages |
| Authors:
Richard A Altschuler; MICHIGAN UNIV ANN ARBOR
|
| Results from the first year of studies indicate that a 2 1/2 minute exposure to a small arms fire - like noise will induce tinnitus in some but not all of the noise-exposed rats. The noise exposure generates a hearing loss (as measured by the auditory brain stem response) ranging from mild to large that correlates with the amount of sensory cell (hair cell) loss induced by the noise. There ... |
|
| Analysis of Polarization Mismatch Loss for Horizontal Linear Feature Detection |
12 Jun 2012 |
8 pages |
| Authors:
Mark A Govoni; Jeffrey S Spak; Lee R Moyer; ARMY COMMUNICATIONS-ELECTRONICS RESEARCH DEVELOPMENT AND ENG CTR APG MD
|
| FOR most airborne radar, target detection is possible when the receiver collects target energy in excess of ground clutter and channel noise. Ground clutter is the predominant impediment to successful detection, and is minimized by varying the grazing angle. Extensive literature exists on backscattering statistics for various terrain types [1, 2]. However, little research exists on the significance of aspect angle and its relationship to polarization mismatch loss. Research has ... |
|
| Mammary Stem/Progenitor Cells and Cancer Susceptibility |
Jun 2012 |
9 pages |
| Authors:
James D Shull; WISCONSIN UNIV MADISON
|
| We proposed to define the quantitative relationship between inherited risk of developing mammary cancer and the number of MaSC under basal and hormone stimulated states in two well characterized inbred rat strains: 1) ACI, which is highly susceptible to 17 -estradiol (E2)-induced/progesterone (P)-dependent mammary cancer; and 2) Brown Norway (BN), which is highly resistant. Major findings: ACI and BN rats likely exhibit significant differences in MaSC number and/or responsiveness to ... |
|
| Improved Round Trip Efficiency for Regenerative Fuel Cell Systems |
11 May 2012 |
23 pages |
| Authors:
Katherine E Ayers; PROTON ENERGY SYSTEMS INC WALLINGFORD CT
|
| In developing technology for air independent undersea vehicle missions, a ground-test breadboard system was adapted and utilized to prove advanced components that enable closed-loop, zero emission, low signature energy storage. The system utilizes proton exchange membrane (PEM) fuel cell and electrolysis technology with proven commercial reliability, and a balance-of-plant primarily consisting of commercial-off-the-shelf (COTS) components. Initial durability testing measured the magnitude of reactant loss to the ambient atmosphere, before replacing ... |
|
| Smart Power Infrastructure Demonstration for Energy Reliability and Security (SPIDERS) |
May 2012 |
20 pages |
| Authors:
Nancy Grandy; DEPARTMENT OF DEFENSE WASHINGTON DC
|
| The ability of today s warfighter to command, control, deploy, and sustain forces is adversely impacted by a fragile, aging, and fossil fuel dependent electricity grid, posing a significant threat to national security. The SPIDERS JCTD will address four critical requirements: Protect task critical assets from loss of power due to cyber attack, Integrate renewable and other distributed generation electricity to power task critical assets in times of emergency, Sustain ... |
|
| Behavioral Analysis and Rescue of a Novel Cerebellar Mouse Model of Tuberous Sclerosis Complex |
May 2012 |
39 pages |
| Authors:
Michael Gambello; TEXAS UNIV HEALTH SCIENCE CENTER AT HOUSTON
|
| The specific aims of this concept award are 1) to conduct a battery of behavioral tests on a cerebellar mouse model of Tuberous sclerosis complex to determine whether Tsc2 mediated Purkinje cell loss induces ASD-like deficits; and 2) to determine whether rapamycin, an mTORC1 inhibitor, rescues the Purkinje cell degeneration and behavioral deficits in mutant mice. Here we report substantial progress on Aim 1. We have performed the battery of ... |
|
| Knowledge Transfer Loss in a Base Realignment and Closure (BRAC) Environment: A Positive or Negative Acquisition Paradigm Shift |
Apr 2012 |
135 pages |
| Authors:
Stanley M Niemiec; DEFENSE ACQUISITION UNIV ABERDEEN PROVING GROUND MD
|
| This study researched the impact of the decision to relocate a large Army Acquisition Workforce from one state to another, and focused on the knowledge transfer from the original New Jersey-based workforce (Fort Monmouth) circa 2005 to the current Maryland-based workforce (Aberdeen Proving Ground) post-2011. Both professional and personal life-changing transitional impacts were considered. The study is based on a single acquisition domain (Army Command, Control, Communications, Computer, Intelligence, Surveillance, ... |
|
| Land And Forest Area Changes In The Vicinity Of The Mississippi River Gulf Outlet, Central Wetlands Region, 1935-2010 |
Mar 2012 |
54 pages |
| Authors:
Christina L Saltus; Glenn M Suir; John A Barras; ENGINEER RESEARCH AND DEVELOPMENT CENTER VICKSBURG MS ENVIRONMENTAL LAB
|
| As part of the overall Mississippi River Gulf Outlet (MRGO) Ecosystem Restoration Study, the Central Wetlands Unit (CWU) is a critical coastal restoration project proposed to mitigate the effects of the MRGO dredging and dredged material placement in southeastern coastal Louisiana. An in-depth knowledge of recent and historical coastal landscape history is a key knowledge element required by project managers to make informed decisions for implementing the overall CWU restoration ... |
|
| Magnetization Losses in Multiply Connected YBa2Cu3O6+x-Coated Conductors (Postprint) |
Feb 2012 |
13 pages |
| Authors:
G A Levin; P N Barnes; Naoyuki Amemiya; Satoshi Kasai; Keiji Yoda; Zhenan Jiang; A Polyanskii; AIR FORCE RESEARCH LAB WRIGHT-PATTERSON AFB OH PROPULSION DIR/POWER DIV/MECHANICAL ENERGY CONVERSION BRANCH
|
| We report the results of a magnetization loss study in experimental multifilament, multiply connected coated superconductors exposed to time-varying magnetic field. In these samples, the superconducting layer is divided into parallel stripes segregated by nonsuperconducting grooves. In order to facilitate the current sharing between the stripes and thus increase the reliability of the striated conductors, a sparse network of superconducting bridges is superimposed on the striated film. We find that ... |
|
| Oxidative Stress Increases the Blood Brain Barrier Permeability Resulting in Increased Incidence of Brain Metastasis in BRCA Mutation Carriers |
Feb 2012 |
7 pages |
| Authors:
Hava Avraham; BETH ISRAEL DEACONESS MEDICAL CENTER BOSTON MA
|
| BRCA1 is a multifunctional tumor suppressive protein. Knockout of WT BRCA1 in breast cancer cells resulted in an increase in cell proliferation, anchorage-independent growth, cell migration, invasion and a loss of p21/Waf1 and P27Kip1 expression. In BRCA1 knocked-down cells, the expression of survivin was significantly up regulated with a decrease in cellular sensitivity to paclitaxel. Cells that harbor endogenous mutant or defective BRCA1 (such as MDA-MB-436 and HCC1937) were highly ... |
|
| Coupling Losses and Transverse Resistivity of Multifilament YBCO Coated Superconductors (Postprint) |
Feb 2012 |
6 pages |
| Authors:
M Polak; E Usak; L Jansak; E Demencik; G A Levin; P N Barnes; D Wehler; B Moenter; AIR FORCE RESEARCH LAB WRIGHT-PATTERSON AFB OH PROPULSION DIR/POWER DIV/MECHANICAL ENERGY CONVERSION BRANCH
|
| We studied the magnetization losses of four different types of filamentary YBCO coated conductors. A 10 mm wide YBCO coated conductor was subdivided into 20 filaments by laser ablation. We measured the frequency dependence of the total losses in the frequency range 0.1 Hz f 608 Hz. The coupling loss was obtained from the total by subtracting the hysteresis loss. The latter was measured at low frequencies since ... |
|
| Transport AC Losses in Striated YBCO Coated Conductors (Postprint) |
Feb 2012 |
6 pages |
| Authors:
G A Levin; P N Barnes; M Majoros; B A Glowacki; A M Campbell; AIR FORCE RESEARCH LAB WRIGHT-PATTERSON AFB OH PROPULSION DIR/POWER DIV/MECHANICAL ENERGY CONVERSION BRANCH
|
| DC current-voltage characteristics and transport ac losses of striated and non-striated Y1Ba2Cu3O7-delta (YBCO) coated conductors have been measured. Transport ac loss measurements have been performed in frequencies from 40 Hz up to 2 kHz at 77.4 K. Degradation in the critical current of about 40% due to the laser striation process has been found. The striated sample was much more thermally stable than the non-striated one. Transport ac losses were ... |
|
| Properties of a YBCO Pancake Coil Operating with AC Current at Frequencies up to 1000 Hz (Postprint) |
Feb 2012 |
6 pages |
| Authors:
M Polak; E Demencik; L Jansak; E Usak; P Mozola; C L Thieme; D Aized; G A Levin; P N Barnes; AIR FORCE RESEARCH LAB WRIGHT-PATTERSON AFB OH PROPULSION DIRECTORATE
|
| A small pancake coil was wound using 1.2m long, 10 mm wide YBCO coated superconductor tape with impregnation by epoxy resin. The coil was immersed in liquid nitrogen and tested in several regimes. In the DC regime, we measured the I-V curve, the hysteresis of the magnetic field-current curve at liquid nitrogen temperature and the radial component of the coil field at the coil edges. The critical currents of a ... |
|
| Suppression of BRCA2 by Mutant Mitochondrial DNA in Prostate Cancer |
Feb 2012 |
14 pages |
| Authors:
Jer-Tsong Hsieh; TEXAS UNIV SOUTHWESTERN MEDICAL SCHOOL AT DALLAS
|
| Mutations in mitochondrial DNA (mtDNA) are frequent in prostate cancer and they seem to occur early during prostate malignant transformation. Depletion of mtDNA in prostate cancer cells has been linked to acquisition of androgenindependence, progression to an invasive phenotype that is resistant to conventional chemotherapies, as well as induction of epithelial-mesenchymal transition leading to cancer metastasis. Using long-range genomic polymerase chain reaction, large deletion of mtDNA can be detected in ... |
|
| Structural Characteristics and Swelling Mechanism of Two Commercial Nitrile-Butadiene Elastomers in Various Fluids |
06 Jan 2012 |
25 pages |
| Authors:
M S Seehra; M Yalamanchi; V Singh; WEST VIRGINIA UNIV MORGANTOWN DEPT OF PHYSICS
|
| Results on the structural characteristics and swelling mechanisms of the two commercial elastomers viz. N0674-70 and peroxide cured N0741-75 in a variety of fluids are reported here. The fluids used in these investigations included toluene, o-xylene, p-xylene, mesitylene, HISOL-15, n-hexane, ethanol, tert-butyl alcohol, acetone, JP-8, S-8 and blends of S-8 plus HISOL-15 and S-8 plus toluene. Both changes in mass and volume of the rectangular disks of the samples were ... |
|
| Modeling and Simulation of Mortar Fin Tooling Using Cyclic Symmetry |
Jan 2012 |
15 pages |
| Authors:
Shana Groeschler; L Reinhardt; Matthew Glaser; ARMY ARMAMENT RESEARCH DEVELOPMENT AND ENGINEERING CENTER PICATINNY ARSENAL NJ
|
| Cyclic symmetry is a method in finite element analysis that allows for the simulation of an entire cyclically symmetrical structure based on a model of one repeating sector. The reduction of model size obtained using cyclic symmetry can significantly reduce computational cost. This technique was employed to optimize the three pronged tooling design used to assemble mortar fins to the mortar body. Using cyclic symmetry, only one-third of the model ... |
|
| The Anticholinergic and Antiglutamatergic Drug Caramiphen Reduces Seizure Duration in Soman-Exposed Rats: Synergism with the Benzodiazepine Diazepam |
Jan 2012 |
12 pages |
| Authors:
M K Schultz; L K Wright; M F Stone; J E Schwartz; N R Kelley; M C Moffett; R B Lee; L A Lumley; ARMY MEDICAL RESEARCH INST OF CHEMICAL DEFENSE ABERDEEN PROVING GROUND MD
|
| Therapy of seizure activity following exposure to the nerve agent soman (GD) includes treatment with the anticonvulsant diazepam (DZP), an allosteric modulator of -aminobutyric acid A (GABAA) receptors. However, seizure activity itself causes the endocytosis of GABAA receptors and diminishes the inhibitory effects of GABA, thereby reducing the efficacy of DZP. Treatment with an N-methyl-D-aspartic acid (NMDA) receptor antagonist prevents this reduction in GABAergic inhibition.We examined the efficacy of the ... |
|
| Extremity War Injuries: Current Management and Research Priorities |
Jan 2012 |
4 pages |
| Authors:
Michael J Bosse; James R Ficke; Romney C Andersen; SAN ANTONIO MILITARY MEDICAL CENTER FORT SAM HOUSTON TX
|
| The United States Armed Forces have been engaged in combat operations for more than 10 years. Not enough can be said about nor enough gratitude expressed to our troops for their commitment and sacrifice during this period. This supplement to the Journal of the American Academy of Orthopaedic Surgeons is dedicated to the men and women of the United States Armed Services and to their families and friends who support ... |
|
| American Recovery and Reinvestment Act -- Improvements Needed in Implementing the Homeowners Assistance Program |
21 Dec 2011 |
53 pages |
| Authors:
Patricia A Marsh; DEPARTMENT OF DEFENSE ALEXANDRIA VA OFFICE OF THE INSPECTOR GENERAL
|
| We determined whether the U.S. Army Corps of Engineers (USACE) processed Homeowners Assistance Program (HAP) applications and payments in accordance with the interim rule published in the Federal Register and implementing guidance. The American Recovery and Reinvestment Act of 2009 allocated $555 million to expand HAP, and the National Defense Authorization Act of 2010 authorized an additional $300 million. USACE district personnel generally made accurate payments to eligible applicants in ... |
|
| Assessment of U.S. Government and Coalition Efforts to Develop the Logistics Sustainment Capability of the Afghan National Army |
09 Dec 2011 |
201 pages |
| Authors:
Kenneth P Moorefield; Stanley E Meyer; DEPARTMENT OF DEFENSE ALEXANDRIA VA OFFICE OF THE INSPECTOR GENERAL
|
| This is the 12th in a series of reports published by the Office of Inspector General's Special Plans and Operations Directorate that focus on the train and equip missions in Iraq, Afghanistan, and Pakistan. On February 14, 2011, the DODIG announced the Assessment of U.S. Government and Coalition Efforts to Develop the Logistics Sustainment Capability of the Afghan National Army. The objectives of this assessment were to determine whether planning ... |
|
| Rotary Engine Friction Test Rig Development Report |
Dec 2011 |
22 pages |
| Authors:
Brian C Huffman; MOTILE ROBOTICS INC JOPPA MD
|
| This report describes the development work to experimentally determine the friction characteristics of the UAV Engines Limited 1100 rotary engine. Background research suggests methods to measure and reduce friction loss. The analytical equations shown are used to determine friction characteristics from experimental measurements. A computer-aided design model of an engine friction test rig was designed and fabricated to test the engine. A computer model of the rotary engine using GT-Power ... |
|
| Development of Second Generation Intact Stability Criteria |
Dec 2011 |
175 pages |
| Authors:
Vadim Belenky; Christopher G Bassler; Konstantinos J Spyrou; NAVAL SURFACE WARFARE CENTER CARDEROCK DIV BETHESDA MD HYDROMECHANICS DEPT
|
| Significant changes in the design and operation of commercial ships have occurred over the last several decades. These changes, and their impact on the intact stability performance of ships, have motivated the development of the second generation intact stability criteria by the IMO Subcommittee on Stability and Load Lines and on Fishing Vessels Safety (SLF). Parametric roll resonance, pure loss of stability, and broaching-to are among the primary modes of ... |
|
| Experimental Testing of the Variable Rotated Elastic Parabolic Equation |
Nov 2011 |
7 pages |
| Authors:
Harry J Simpson; Jon M Collis; Raymond J Soukup; Michael D Collins; William L Siegmann; NAVAL RESEARCH LAB WASHINGTON DC PHYSICAL ACOUSTICS BRANCH
|
| A series of laboratory experiments was conducted to obtain high-quality data for acoustic propagation in shallow water waveguides with sloping elastic bottoms. Accurate modeling of transmission loss in these waveguides can be performed with the variable rotated parabolic equation method. Results from an earlier experiment with a flat or sloped slab of polyvinyl chloride (PVC) demonstrated the necessity of accounting for elasticity in the bottom and the ability of the ... |
|
| Desorption and Transformation of Nitroaromatic (TNT) and Nitramine (RDX and HMX) Explosive Residues on Detonated Pure Mineral Phases |
Nov 2011 |
14 pages |
| Authors:
Thomas A Douglas; Marianne E Walsh; Jr Weiss Charles A; Christian J McGrath; Thomas P Trainor; COLD REGIONS RESEARCH AND ENGINEERING LAB FORT WAINWRIGHT AK
|
| Explosive compounds, including known toxicants 2,4,6-trinitrotoluene (TNT) and hexahydro- 1,3,5-trinitro-1,3,5-triazine (RDX), are loaded to soils during military training. Their fate in soils is ultimately controlled by soil mineralogical and biogeochemical processes. We detonated pure mineral phases with Composition B, a mixture of TNT and RDX, and investigated the fate of detonation residues in aqueous slurries constructed from the detonated minerals. The pure minerals included Ottawa sand (quartz and calcite), microcline ... |
|
| Effect of Teriparatide, Vibration and the Combination on Bone Mass and Bone Architecture in Chronic Spinal Cord Injury |
Oct 2011 |
8 pages |
| Authors:
Thomas J Schnitzer; NORTHWESTERN UNIV EVANSTON IL
|
| Severe bone loss commonly occurs in individuals with chronic spinal cord injury who are non-weightbearing and leads to an increased risk of lower extremity fractures. This multi-site, double-blind, randomized, placebo-controlled study evaluates the efficacy and safety of two interventions known to be anabolic to bone, parathyroid hormone and mechanical loading (provided as teriparatide and vibration) in 60 SCI individuals with low bone mass. After the first year of this project, ... |
|
| Seeking Safety Therapy for PTSD, TBI, and Substance Use Disorder |
Oct 2011 |
64 pages |
| Authors:
Lisa M Najavits; TREATMENT INNOVATIONS LLC NEWTON CENTER MA
|
| The purpose of this study is to conduct a randomized controlled trial of Seeking Safety (SS) therapy for TBI patients with PTSD and substance use disorder, comparing SS to treatment-as-usual, with a sample of 60 patients and 15 clinicians. This year, we had two unanticipated setbacks. but also made major progress. The setbacks were the loss of sites due to points of contact retiring or being reassigned; and the exceptionally ... |
|
| Quantitative Tractography and Volumetric MRI in Blast and Blunt Force TBI: Predictors of Neurocognitive and Behavioral Outcome |
Oct 2011 |
6 pages |
| Authors:
Lisa Delano-Wood; VETERANS MEDICAL RESEARCH FOUNDATION (VETERANS AFFAIRS) SAN DIEGO CA
|
| Our primary aims have been to determine whether frontal WM microstructural integrity accounts for disparate cognitive outcomes in executive function following mild TBI (mTBI) and to determine if injury severity, as measured by loss of consciousness (LOC), is related to neuropsychological outcome and WM microstructural integrity. We examined a subgroup of mTBI participants with executive dysfunction and compared them to a group with intact executive functioning on DTI measures. Results ... |
|
| Monthly Distribution of Shipping Vessels within the Monterey Bay National Marine Sanctuary, January-December 2010 |
Sep 2011 |
43 pages |
| Authors:
Christopher W Miller; NAVAL POSTGRADUATE SCHOOL MONTEREY CA DEPT OF OCEANOGRAPHY
|
| After the discovery of a 40-foot shipping container resting on the ocean floor within the Monterey Bay National Marine Sanctuary (MBNMS), the MBNMS began a study to research the impact that containers lost at sea might have on the marine environment. The Naval Postgraduate School Oceanography Department was approached to provide some measure of the total shipping which passes within the boundaries of the MBNMS. Utilizing the Automated Identification System ... |
|
| Investigation of Transitional Flows on Compressor Blades in Cascade |
Sep 2011 |
111 pages |
| Authors:
Michael L Holihan; NAVAL POSTGRADUATE SCHOOL MONTEREY CA
|
| Flow around polished second-generation controlled-diffusion blades in cascade set at their design inlet flow angle was investigated at various Reynolds numbers using static pressure measurements, five-hole probe surveys, twocomponent laser Doppler velocimetry (LDV), computational fluid dynamics and flow visualization. A suction-side separation bubble formed at Reynolds number, based on chord length, of 203,000 and collapsed by a Reynolds number of 393,000. Five-hole probe surveys characterized the blade-row inlet and outlet ... |
|
| Sealing Penetrating Eye Injuries Using Photo-Activated Bonding |
Sep 2011 |
16 pages |
| Authors:
Irene E Kochevar; MASSACHUSETTS GENERAL HOSPITAL BOSTON
|
| Purpose: To develop a light-activated technology (called PTB) with the potential to decrease vision loss and ocular complications in warfighters sustaining penetrating eye injuries. Scope: In year 2, the scope was to establish the treatment for direct photo-sealing of corneal lacerations, to identify the best treatment for sealing eyelid skin lacerations, and to optimize and build a prototype light delivery system that is safe for the retina. Major findings: Demonstrated ... |
|
| Control of Metastatic Colonization in Prostate Cancer: The Functional Mechanism of Metastasis Suppression by JNKK1/MKK4 |
Sep 2011 |
21 pages |
| Authors:
Russell Szmulewitz; CHICAGO UNIV IL
|
| The purpose of the award was to provide Dr. Szmulewitz with training in basic and translational prostate cancer (PC) research. The scientific focus is PC metastasis modeling and modulation of metastatic colonization (the specific outgrowth of microscopic disseminated cancer cells to overt macroscopic metastases) through the prostate cancer metastasis suppressor JNKK1/MKK4. In addition the scope of the award also includes key training opportunities. Over the second year of this award ... |
|
| TPD52: A Novel Vaccine Target for Prostate Cancer |
Sep 2011 |
20 pages |
| Authors:
Robert Bright; TEXAS TECH UNIV HEALTH SCIENCES CENTER LUBBOCK
|
| Tumor protein D52 (D52) is a novel self-onco-antigen involved in cellular transformation, proliferation and metastasis that is over-expressed in prostate cancer cells. The overall goal of this Award is to test the efficacy of D52-based vaccines in the TRAMP murine model of prostate cancer, and to characterize vaccine induced mechanisms of tumor immunity. Due to unforeseen circumstances during this funding period primarily involving the animal vendor and maternity leave for ... |
|
| Autophagy Signaling in Prostate Cancer: Identification of a Novel Phosphatase |
Aug 2011 |
33 pages |
| Authors:
Jeffrey P MacKeigan; VAN ANDEL RESEARCH INSTITUTE GRAND RAPIDS MI
|
| Phosphatidylinositol-3-phosphate (PI(3)P) is concentrated on autophagic vesicles and recruits effector proteins critical for this process. The production of PI(3)P by the class III phosphatidylinositol 3-kinase (PI3K), Vps34, has been well established; however, phosphatases which antagonize this early step in autophagy are not clear. To identify such enzymes, we screened human phosphatase genes by RNA interference (RNAi) and found that loss of PTPsigma, a dual-domain protein tyrosine phosphatase (PTP), increases cellular ... |
|
| Role of the ARF Tumor Suppressor in Prostate Cancer |
Aug 2011 |
29 pages |
| Authors:
Leonard B Maggi; WASHINGTON UNIV ST LOUIS MO
|
| The nucleolar tumor suppressor ARF plays an important role in the tumor surveillance of human cancer. We have found that ARF expression is absent from highly proliferative prostate adenocarcinomas. This correlates with the normal expression of the p53 tumor suppressor gene indicating that ARF loss could be a contributing factor for prostate cancer initiation and/or progression. We have found that ARF-mull mice develop prostatic lesions by 9 months of age ... |
|
| Does EMT Contribute to Radiation Resistance of Human Breast Cancer? |
Aug 2011 |
8 pages |
| Authors:
Anupama Munshi; OKLAHOMA CITY UNIV OK
|
| E-cadherin, is the major adhesion protein associated with epithelial malignancies and loss of E-cadherin expression is diagnostic of EMT in such cells. Loss of E-cadherin plays an important role in breast cancer progression, invasion and metastasis and is used as a prognostic marker for breast cancer. E-cadherin expression is significantly reduced in basal-like and triple negative breast cancers and a higher proportion of E-cadherin aberrations are observed in ER- negative ... |
|
| Mechanisms of KAI1/CD82-Induced Prostate Cancer Metastasis |
Aug 2011 |
40 pages |
| Authors:
Cynthia Miranti; VAN ANDEL RESEARCH INSTITUTE GRAND RAPIDS MI
|
| Metastatic prostate cancer kills over 28,000 American men every year. The mechanisms that drive metastasis are poorly understood. We investigated the hypothesis that loss of the metastasis suppressor gene, CD82/KAI1 in primary prostate tumors of genetically engineered mice would be sufficient to induce metastasis. While CD82 was sufficient to suppress metastasis of metastatic tumor cells lines and did so by repressing c-Met, the reverse was not true, i.e. loss of ... |
|
| Hic-5's Regulatory Role in TGFB Signaling In Prostate Stroma |
Jul 2011 |
15 pages |
| Authors:
Melanie Grubisha; PITTSBURGH UNIV PA
|
| In this study, we attempt to demonstrate that a reactive stroma maintains the ability to restrain cancer cell motility, but this inhibition is lost when local TGF production stimulates an increased production of stromal ROS that in turn inactivates the inhibitor. We show that in the absence of TGF , a myofibroblastic prostate stromal cell (WPMY 1) produces a motility inhibitory factor that limits motility in a highly aggressive PCa ... |
|
| Genetically Modified Porcine Skin Grafts for Treatment of Severe Burn Injuries |
Jul 2011 |
28 pages |
| Authors:
David Sachs; MASSACHUSETTS GENERAL HOSPITAL BOSTON
|
| The most significant research findings in this time period include: 1) data supporting the effectiveness of skin grafts from genetically-modified swine transplanted onto full-thickness wounds on baboons when compared to the standard treatment (allogeneic skin); 2) that the use of these swine skin grafts will not sensitize the recipientto the use of a subsequent allogeneic graft if needed for prolonged wound coverage; 3) that topical immunosuppression initiated immediately after grafting ... |
|
| Histone Code Modulation by Oncogenic PWWP-Domain Protein in Breast Cancers |
JUN 2011 |
12 pages |
| Authors:
Zeng-Quan Yang; WAYNE STATE UNIV DETROIT MI
|
| Amplification of 8p11-12 occurs in approximately 15% of human breast cancer (HBC), and this region of amplification is significantly associated with disease-specific survival and distant recurrence in breast cancer patients. Earlier, we used genomic analysis of copy number and gene expression to perform a detailed analysis of the 8p11-12 amplicon for identifying candidate oncogenes in breast cancer. We identified Wolf-Hirschhorn syndrome candidate 1-like 1 (WHSC1L1) as a candidate oncogene based ... |
|
| Water Loss Control for Military Installations |
12 May 2011 |
41 pages |
| Authors:
Richard J Scholze; ENGINEER RESEARCH AND DEVELOPMENT CENTER CHAMPAIGN IL CONSTRUCTION ENGINEERING RESEARCH LAB
|
|
| Survivability and Recovery of Degraded Communication Networks |
04 May 2011 |
6 pages |
| Authors:
Linda Zeger; Ira Kohlberg; MASSACHUSETTS INST OF TECH LEXINGTON LINCOLN LAB
|
| When multiple nodes in a network are subject to failure or loss, the question arises as to whether communication across the resulting degraded network is feasible. Percolation theory and random graph theory have been previously used to answer this question. Here we extend random geometric graph theory to the case of networks with some randomness in link formation. In addition, initial steps toward addressing the little studied question as to ... |
|
| National Manufacturing Strategy: Is a National Manufacturing Strategy Essential to National Security? |
01 May 2011 |
34 pages |
| Authors:
John M Anderson; TEXAS UNIV AT AUSTIN
|
| Congress introduced the National Manufacturing Strategy Act of 2010 on 25 February 2010. The act proposes a quadrennial comprehensive analysis of the manufacturing sector and creation of a national manufacturing strategy. A Congressional Research Service Summary concludes that the goals of the act include the following: the creation of government policies promoting economic growth; increasing productivity, exports, and global competitiveness; and improving national security. Recently, the Chairman of Joint Chiefs ... |
|
| Improved Therapeutic Regimens for Treatment of Post-Traumatic Ocular Infections |
May 2011 |
44 pages |
| Authors:
Michelle Callegan; OKLAHOMA UNIV HEALTH SCIENCES CENTER OKLAHOMA CITY
|
| Greater than 10% of battlefield injuries occur to the eyes, resulting in significant morbidity. The potential for ocular infection by trauma is high, due to the types of organisms encountered in arid environments and the delay between injury and adequate treatment. This proposal was designed to analyze the effectiveness of antibiotics, anti-inflammatory drugs, and non-conventional agents targeting bacterial and host virulence factors, with the goal of improving the outcome of ... |
|
| Spatio-temporal Theory of Lasing Action in Optically-Pumped Rotationally Excited Molecular Gases |
11 Apr 2011 |
19 pages |
| Authors:
Song-Liang Chua; Christine A Caccamise; Dane J Phillips; John D Joannopoulos; Marin Soljacic; Henry O Everitt; Jorge Bravo-Abad; MASSACHUSETTS INST OF TECH CAMBRIDGE DEPT OF ELECTRICAL ENGINEERING AND COMPUTER SCIENCE
|
| We investigate laser emission from optically-pumped rotationally excited molecular gases confined in a metallic cavity. To this end we have developed a theoretical framework able to accurately describe both in the spatial and temporal domains, the molecular collisional and diffusion processes characterizing the operation of this class of lasers. The effect on the main lasing features of the spatial variation of the electric field intensity and the ohmic losses associated ... |
|
Reports by Keyword(s)
LOSSES
