| Genome, Functional Gene Annotation, and Nuclear Transformation of the Heterokont Oleaginous Alga Nannochloropsis oceanica CCMP1779 |
15 Nov 2012 |
27 pages |
| Authors:
Astrid Vieler; Guangxi Wu; Chia-Hong Tsai; Blair Bullard; Adam J Cornish; Christopher Harvey; Ida-Barbara Reca; Chelsea Thornburg; Rujira Achawanantakun; Christopher J Buehl; MICHIGAN STATE UNIV EAST LANSING DEPT OF BIOCHEMISTRY
|
 | Unicellular marine algae have promise for providing sustainable and scalable biofuel feedstocks, although no single species has emerged as a preferred organism. Moreover, adequate molecular and genetic resources prerequisite for the rational engineering of marine algal feedstocks are lacking for most candidate species. Heterokonts of the genus Nannochloropsis naturally have high cellular oil content and are already in use for industrial production of high-value lipid products. First success in applying ... |
|
| Development of a Novel Synthetic Drug for Osteoporosis and Fracture Healing |
Sep 2012 |
21 pages |
| Authors:
Hiroki Yokota; INDIANA UNIV INDIANAPOLIS
|
| This is a progress report (year 1) for developing a novel therapeutic drug for skeletal diseases, in particular focusing on administration of salubrinal for treatment of osteoporosis and bone fracture. A formulation for salubrinal was determined and an effective dosage was identified. Using ovariectomized mice, administration of salubrinal was shown to reduce body weight and fat weight, and to prevent reduction in uterus weight and BMD/BMC. Salubrinal was also shown ... |
|
| Regulation of Mammary Tumor Formation and Lipid Biosynthesis by Spot14 |
Oct 2011 |
18 pages |
| Authors:
Elizabeth Wellberg; COLORADO UNIV AURORA CO
|
| The objective of this study is to develop models to causatively link Spot 14 (S14) expression in the mammary epithelium and tumor formation, metabolism, and metastasis. Our hypothesis is that S14 promotes de novo lipid biosynthesis in tumor cells, causing enhanced proliferation and ultimately, tumor metastasis. Using a genetic model of spontaneous tumorigenesis, we have found that the presence of S14 significantly accelerates tumor latency, and is associated with branching ... |
|
| Fish Oil Supplementation and Fatty Acid Synthase Expression in the Prostate: A Randomized Controlled Trial. Addendum |
Jul 2011 |
13 pages |
| Authors:
Jackilen Shannon; OREGON HEALTH AND SCIENCE UNIV PORTLAND
|
| One in seven men over the age of 60 will be diagnosed with prostate cancer. Elucidation of early cellular changes that may predict progression to prostate cancer and the identification of factors that may inhibit or reverse these cellular changes would be of great clinical significance. Alteration of the fatty acid synthase (FAS) pathway is an early cellular change that has recently come under investigation. Overexpression of the lipogenic enzyme ... |
|
| A Novel Anti-Beta2-Microglobulin Antibody Inhibition of Androgen Receptor Expression, Survival, and Progression in Prostate Cancer Cells |
MAY 2011 |
23 pages |
| Authors:
Wen-Chin Huang; CEDARS-SINAI MEDICAL CENTER LOS ANGELES CA
|
| Beta2-microglobulin (beta2M) is a signaling and growth-promoting factor stimulating prostate cancer cell proliferation and progression. Blockade of the beta2M signaling axis by anti-beta2M monoclonal antibody (beta2M mAb) resulted in the inhibition of androgen receptor (AR) and its target gene, prostate-specific antigen (PSA), and the induction of programmed death of prostate cancer cells in vitro and in vivo. We identified a new cis-acting element, sterol regulatory element-binding protein-1 (SREBP-1) binding site, ... |
|
| Aldo-keto Reductase Family 1 B10 as a Novel Target for Breast Cancer Treatment |
AUG 2010 |
18 pages |
| Authors:
Deliang Cao; Jun Ma; Dixian Luo; Yi Shen; SOUTHERN ILLINOIS UNIV SCHOOL OF MEDICINE SPRINGFIELD
|
| Breast cancer is the most common carcinoma of women in the United States, accounting for more than 40,000 American women's deaths annually. Targeted therapies, such as tamoxifen in estrogen receptor-positive breast cancer, have led to major important improvements in the outcomes of this cancer, but effective chemotherapy targets are lacking and the mortality rate of advanced breast cancer is still high. Aldo-keto reductase 1 B10 (AKR1B10) is overexpressed in tested ... |
|
| Inhibitors of Fatty Acid Synthase for Prostate Cancer |
31 MAY 2010 |
44 pages |
| Authors:
Steven J. Kridel; WAKE FOREST UNIV WINSTON-SALEM NC SCHOOL OF HEALTH SCIENCES
|
| Fatty acid synthase (FASN), the enzyme that synthesizes fatty acid in cells, is over-expressed in prostate cancer and a potential therapeutic target. We have identified several novel chemical scaffolds with potential to inhibit FASN. An extensive series of anti-FASN pharmacophores has been synthesized and characterized for their ability to inhibit recombinant FASN, FASN activity in tumor cells, and to kill prostate cancer cell lines. The best inhibitors have increased potency ... |
|
| Transcriptional Profiling of Francisella tularensis Infected Peripheral Blood Monomuclear Cells: A Predictive Tool for Tularemia |
01-Jan-2008 |
13 pages |
| Authors:
Chrysanthi Paranavitana; Phillip R Pittman; Mahendran Velauthapillai; Elzbieta Zelazowska; Luis DaSilva; WALTER REED ARMY INST OF RESEARCH SILVER SPRING MD
|
| We studied early temporal gene expression in human peripheral blood mononuclear cells after in vitro infection with Francisella tularensisi live vaccine strain. Recently, investigators from Sweden studied ulceroglandular tularemia by gene expression profiling of blood from patients with active ongoing infection. Host responses to tularemia were described in their study of several potential genes as biomarkers for early tularemia. Most of the host genes related to tularemia were confirmed in ... |
|
| High Energy Density Nastic Structures Using Biological Transport Mechanisms |
28 FEB 2007 |
33 pages |
| Authors:
Donald J. Leo; VIRGINIA POLYTECHNIC INST AND STATE UNIV BLACKSBURG DEPT OF MECHANICAL ENGINEERING
|
| A new mechanical actuation concept is demonstrated based on the controlled transport of fluid across semi-permeable membranes. This concept is based on the pressurization of cells similar to the process that plants use to maintain homeostasis and regulate cell function. In all plant systems, the transport of ions and fluid produce localized pressure changes (called turgor pressure) that perform many cell functions, such as maintaining cell integrity and controlling plant ... |
|
| Activation of Polymine Catabolism as a Novel Strategy for Treating and/or Preventing Human Prostate Cancer |
MAR 2006 |
59 pages |
| Authors:
Carl W. Porter; HEALTH RESEARCH INC BUFFALO NY
|
| We proposed that activation of polyamine catabolism as opposed to inhibition of polyamine biosynthesis will have a therapeutic effect against prostate carcinoma. Thus, we found that (a) conditional overexpression of the polyamine catabolic enzyme spermidine /spermine N1-acetyltransferase (SSAT) causes growth inhibition in LNCaP prostate carcinoma cells via a unique mechanism and (b) transgenic overexpression of SSAT in TRAMP mice markedly suppresses prostate tumor development. Both effects were found to occur ... |
|
| Small Molecules That Suppress IGF-Activated Prostate Cancers |
APR 2005 |
8 pages |
| Authors:
Motonari Uesugi; BAYLOR COLL OF MEDICINE HOUSTON TX
|
| Elevated serum levels of insulin-like growth factor 1 (IGF1) have been found in prostate cancer patients, and IGF1-related signal transduction is thought to be an important factor in the development of prostate cancers. The goals of this project are to discover small organic molecules that suppress ICE-activated prostate cancers by cell-based screening and to analyze their action mechanisms. In the first year of funding, we discovered, from our collection of ... |
|
| The Contribution of Hypoxia-Inducible Factor (HIF)-1a to Normal Mammary Gland Development and Mammary Tumorigenesis |
OCT 2004 |
21 pages |
| Authors:
Tiffany N. Seagroves; Randall S. Johnson; CALIFORNIA UNIV SAN DIEGO LA JOLLA
|
| During pregnancy the mammary epithelium and it supporting vasculature rapidly expand to prepare for lactation. To investigate the role of oxygenation and metabolism in these processes, the oxygen-responsive component of the hypoxia-inducible factor (HIF)-l complex, HIF-1 (, was deleted in the murine mammary gland using the Cre/ioxP system. Although vascular density was similar, loss of HIF-l(impaired mammary differentiation and lipid metabolism, culminating in lactation failure (Objective#i). HIF-l(over-expression has been reported ... |
|
| Proteome Analysis of Rhoptry-Enriched Fractions Isolated From Plasmodium Merozoites |
2004 |
8 pages |
| Authors:
Tobili Y. Sam-Yellowe; Laurence Florens; Tongmin Wang; J. D. Raine; Daniel J. Carucci; Robert Sinden; III Yates John R.; CLEVELAND STATE UNIV OH
|
| The rhoptries of Plasmodium species participate in merozoite invasion and modification of the host erythrocyte. However, only a few rhoptry proteins have been identified using conventional gene identification protocols. To investigate the protein organization of this organelle and to identify new rhoptry proteins, merozoite rhoptries from three different Plasmodium rodent species were enriched by sucrose density gradient fractionation, and subjected to proteome analysis using multidimensional protein identification technology (MudPIT); 148 ... |
|
| The Contribution of Hypoxia-Inducible Factor (HIF) -1 Alpha to Normal Mammary Gland Development and Mammary Tumorigenesis |
OCT 2003 |
41 pages |
| Authors:
Tiffany N. Seagroves; CALIFORNIA UNIV SAN DIEGO LA JOLLA
|
| During pregnancy the mammary epithelium and its supporting vasculature rapidly expand to prepare for lactation. To investigate the role of oxygenation and metabolism in these processes the oxygen-responsive component of the hypoxia-inducible factor (HIF)-1 complex, HIF-1 alpha, was deleted in the murine mammary gland using the Cre/loxP system. Although vascular density remained similar, loss of HIF-1 alpha impaired mammary differentiation and lipid metabolism, culminating in lactation failure and changes in ... |
|
| Fatty Acid Synthesis and Prostate Cancer: Hormonal Regulation and Anti- Metabolite targeting of an Acquired Function in Neoplasia |
OCT 2002 |
53 pages |
| Authors:
Ellen S. Pizer; JOHNS HOPKINS UNIV BALTIMORE MD SCHOOLOF MEDICINE
|
| The overall goal of this project is to determine the regulatory mechanisms that activate fatty acid (FA) synthetic metabolism during malignant progression of prostate cancer, and to evaluate FA synthesis as a therapeutic target. The biosynthetic enzyme, fatty acid synthase (FAS), is expressed at elevated levels in PCa cells and is a marker of tumors with activated FA synthesis. While PAS expression is androgen responsive, it persists or is reactivated ... |
|
| Effects of Endurance and Resistance Training on Cardiovascular Risk in Military Eligible Women |
OCT 2001 |
154 pages |
| Authors:
Andrew W. Gardner; Eric T. Poehlman; MARYLAND UNIV BALTIMORE
|
| The overall Hypothesis is that the decline in physical activity habits and resultant increase in body fat reduce exercise capacity and muscle mass in military women. These lifestyle changes worsen cardiovascular risk factors. Therefore, continued involvement in resistance and endurance training exercise programs, which increases or preserves fat free mass, as well as enhances physical activity will prevent functional declines in military-eligible women. Although exercise is frequently recommended to enhance ... |
|
| Molecular Mechanisms of Dietary Fatty Acids on Breast Cancer Growth and Development |
FEB 2001 |
22 pages |
| Authors:
Michael W. Kilgore; KENTUCKY UNIV LEXINGTON
|
| The link between diet and breast cancer has been long postulated and recently, extensively investigated. Identifying a molecular mechanism linking diet and breast cancer, however, has remained elusive. Recently, we identified an isoform of the cellular receptor called the peroxisomal proliferator- activated receptor (PPAR) in several human breast cancer cell lines. Activation of PPAR can alternatively lead to tumor induction or differentiation into a more benign state, depending on the ... |
|
| Physiologically Based Pharmacokinetic Models for the Transport of Trichloroethylene in Adipose Tissue |
2001 |
28 pages |
| Authors:
R. A. Albanese; H. T. Banks; M. V. Evans; L. K. Potter; AIR FORCE RESEARCH LAB BROOKS AFB TX
|
| In this paper we present three physiologically based pharmacokinetic (PBPK) models for the systemic transport of trichloroethylene (TCE), with a focus on the adipose, or fat tissue. TCE is a widespread environmental contaminant, and has been shown to produce toxic effects in both animals and humans. A key characteristic of TCE is its tendency to accumulate in fat tissue, which has a major impact on the overall systemic disposition of ... |
|
| Regulation of Genes Controlling Carbohydrate Metabolism in the Heart of a Hibernating Mammal |
15 DEC 2000 |
7 pages |
| Authors:
Matthew T. Andrews; NORTH CAROLINA STATE UNIV AT RALEIGH DEPT OF GENETICS
|
| During hibernation, mammals rely heavily on lipid stores to provide the fuel necessary to survive the winter. Pyruvate dehydrogenase kinase isozyme 4 (PDK4) plays a key role in gating carbohydrate catabolism and allowing the switch to lipid metabolism. Earlier we reported that PDK-4 was up- regulated in the heart of the thirteen-lined ground squirrel during hibernation. PDK-4 is encoded by the nuclear genome and acts by phosphorylating pyruvate dehydrogenase (PDH) ... |
|
| Molecular Mechanisms of Dietary Fatty Acids on Breast Cancer Growth and Development |
JAN 2000 |
51 pages |
| Authors:
Michael W. Kilgore; CLEMSON UNIV SC
|
| The link between diet and breast cancer has been long postulated and recently, extensively investigated. Identifying a molecular mechanism linking diet and breast cancer, however, has remained elusive. Recently, we identified an isoform of the cellular receptor called the peroxisomal proliferator- activated receptor (PPAR) in several human breast cancer cell lines. Activation of PPAR can alternatively lead to tumor induction or differentiation into a more benign state, depending on the ... |
|
| Metabolic Response to Food Restriction in Military-Eligible Women with a Gender Comparison |
OCT 1999 |
|
| Authors:
Vernon R. Young; MASSACHUSETTS INST OF TECH CAMBRIDGE
|
 | The metabolic responses to a complete 74 hour fast (CF) and to a more prolonged 21 day period of hypocaloric intake (HC) were investigated in healthy military-eligible women and comparisons mad with those in healthy military- eligible men. The CF study included a study of leucine flux, glucose production, glycerol and free fatty acid appearance rates. The pattern of change in substrate utilization revealed the expected shift toward oxidation of ... |
|
| Metabolic Response to Food Restriction in Military-Eligible Women, with a Gender Comparison |
OCT 1998 |
|
| Authors:
Vernon R. Young; MASSACHUSETTS INST OF TECH CAMBRIDGE
|
| Two major series of investigations are being undertaken to explore the metabolic responses of women who meet military standards for body-weight andpercent body-fat to the nutritional stressors of food restriction. A comparison of their responses is being made with those occurring in men, who also meet the standards established by the military. The first series (Series 1) has been devoted to the temporal (progressive) changes in lipid, carbohydrate and proteinmetabolism ... |
|
| Effects of Endurance and Resistance Training on Cardiovascular Risk in Military Eligible Women |
OCT 1998 |
40 pages |
| Authors:
Andrew W. Gardner; Eric T. Poehlman; MARYLAND UNIV BALTIMORE
|
| The overall hypothesis is that the decline in physical activity habits and resultant increase in body fat reduces exercise capacity and muscle mass in military women. These lifestyle changes worsen cardiovascular risk factors. Therefore, continued involvement in resistance and endurance exercise programs which increases or preserves fat-free mass, as well as enhances physical activity will prevent functional declines in military-eligible women. Although exercise is frequently recommended to enhance overall fitness, ... |
|
| Metabolic Response to Food Restriction in Military-Eligible Women, with a Gender Comparison |
OCT 1997 |
|
| Authors:
Vernon R. Young; MASSACHUSETTS INST OF TECH CAMBRIDGE
|
| Two major series of investigations are being undertaken to explore the metabolic responses of women who meet military standards for body-weight and percent body-fat to the nutritional stressors of food restriction. A comparison of their responses is being made with those occurring in men, who also meet the standards established by the military. The first series (Series 1) has been devoted to the temporal (progressive) changes ... |
|
| Effects of Endurance and Resistance Training on Cardiovascular Risk in Military Eligible Women |
OCT 1997 |
38 pages |
| Authors:
Andrew W. Gardner; Eric T. Poehlman; MARYLAND UNIV BALTIMORE
|
| The overall hypothesis is that the decline in physical activity habits and resultant increase in body fat reduces exercise capacity and muscle mass in military women. These lifestyle changes worsen metabolic and cardiovascular risk factors. Therefore, continued involvement in resistance and endurance exercise programs which increases or preserves fat-free mass, as well as enhances physical activity will prevent functional declines in military- eligible women. Although exercise is frequently recommended to ... |
|
| Metabolic Response to Food Restriction in Military-Eligible Women, With a Gender Comparison |
OCT 1996 |
|
| Authors:
Vernon R. Young; MASSACHUSETTS INST OF TECH CAMBRIDGE
|
| Two major series of investigations will be undertaken to explore the metabolic responses of women, who meet military standards of body-weight and percent body-fat to the nutritional stressors of food restriction. A comparison of their responses will be made with those occurring in men, who also meet the standards established by the military. The first series (Series I) will be devoted to the temporal (Progressive) changes in lipid, carbohydrate and ... |
|
| Woodbridge Research Facility Remedial Investigation/Feasibility Study. Health and Safety Plan |
SEP 95 |
100 pages |
| Authors:
Patricia Thompson; Gary McKown; Jeff Waugh; William Houser; Gerald Joy; ICF KAISER ENGINEERS INC ABINGDON MD
|
| The requirements set forth in 29 CFR 1910.120(f), shall be met for all employees performing or supervising hazardous waste operations. Medical exams shall be conducted as soon as possible upon notification by an employee that he/she has developed signs or symptoms indicating possible health hazards or overexposure to hazardous substances. Subcontractor personnel shall provide documentation of current status of participation in a medical surveillance program as required by 29 CFR ... |
|
| The Metabolic and Thermoregulatory Responses of Rhesus Monkeys to Combined Exercise and Environmental Heat Load |
AUG 93 |
27 pages |
| Authors:
Cristine L. Heaps; Stefan H. Constable; KRUG LIFE SCIENCES SAN ANTONIO TX SAN ANTONIO DIV
|
| The purpose of the present research was to characterize the effects of selected physiological stressors such as work and various environmental heat loads in rhesus monkeys. Nonhuman primates (N=6) were behaviorally conditioned to exercise in a wheel ergometer at about 3 METs. Core temperature (Tco), body weight (BW) and blood samples were taken immediately before and after exercise. Excessively high heat storage rates dictated that the 35 C trial be ... |
|
| Involvement of Lipid Metabolism in Chemical Transmission Processes at Mossy Fiber Synapses |
29 JAN 92 |
5 pages |
| Authors:
Robert V. Dorman; KENT STATE UNIV OH DEPT OF BIOLOGICAL SCIENCES
|
| In 1991 we continued our investigations on the involvement of membrane lipid metabolism in the presynaptic processes related to the evoked release of the neurotransmitter glutamate. In particular, we observed that the phospholipase A2-dependent release of arachidonic acid from mossy fiber membrane phospholipids may modulate transmitter secretion through interactions with protein kinase c (PKC). The activation of PKC may explain the previously observed facilitation of depolarization-evoked Ca2+ accumulation and glutamate ... |
|
| Ecology of Archaebacteria from Extreme Environments and the Initial Microfouling Community by Biosignatures |
11 OCT 91 |
4 pages |
| Authors:
David C. White; TENNESSEE UNIV KNOXVILLE INST FOR APPLIED MICROBIOLOGY
|
| The research program represented a consolidation of three research programs (1) the examination of the lipid metabolism of the Archaebacteria from the hydrothermal vents, (2) the analysis of the initial microfouling community using ultrasensitive signature lipid biomarker techniques, and (3) the development of an assessment program for the detection of microbial biofouling on painted surfaces for the Antifouling Coatings Development Program. Significant progress was made in detecting and monitoring the ... |
|
| Ecology of Archaeabacteria for Extreme Environments and the Initial Microfouling Community by Signature Biomarker Techniques |
11 OCT 91 |
5 pages |
| Authors:
David C. White; TENNESSEE UNIV KNOXVILLE INST FOR APPLIED MICROBIOLOGY
|
| The research program represented a consolidation of three research programs (1) the examination of the lipid metabolism of the Archaebacteria from the hydrothermal vents, (2) the analysis of the initial microfouling community using ultrasensitive signature lipid biomarker techniques, and (3) the development of an assessment program for the detection of microbial biofouling on painted surfaces for the Antifouling Coatings Developement Pro Significant progress was made in detecting and monitoring the ... |
|
| Level of Dietary Fat Does Not Affect Fuel Oxidation or Endurance Exercise Performance of Soldiers |
15 MAR 91 |
84 pages |
| Authors:
R. W. Hoyt; T. E. Jones; M. S. Rose; V. A. Forte Jr; M. J. Durkot; ARMY RESEARCH INST OF ENVIRONMENTAL MEDICINE NATICK MA
|
| The objective was to determine whether additional dietary fat calories influenced the physiology or endurance exercise performance of physically active soldiers. Eight male soldiers (age 22.2 yrs, X + or - SEM) participated in two five-day test cycles while eating either a basal diet (2300 kcal; 40% fat Calories) alone or with additional fat calories (3300 kcal and 57% fat Calories). Carbohydrate (300g/day) and protein (70 g/day) levels were kept ... |
|
| Toxicology of Perfluorodecanoic Acid |
01 NOV 90 |
17 pages |
| Authors:
Richard E. Peterson; WISCONSIN UNIV-MADISON SCHOOL OF PHARMACY
|
| Despite hypothyroxinemia, PFDA-treated rats are not functionally hypothyroid. Furthermore, any alteration in functional thyroid status can be dissociated from the overt toxicity (i.e., severe hypophagia and body weight loss). PFDA exerts effects on neutral lipid metabolism in both liver and carcass of the rat. At 7 days following a single administration of PFDA, hepatic esterification of free fatty acid into TG and CE was increased yet the expected augmentation in ... |
|
| Mode of Action of Membrane Perturbing Agents: Snake Venom Cardiotoxins and Phospholipases A |
30 JUN 90 |
28 pages |
| Authors:
Jeffrey E. Fletcher; HAHNEMANN UNIV SCHOOL OF MEDICINE PHILADELPHIA PA
|
| CTXs have at least two mechanisms of action. The first has a rapid onset and is reversible. The second has a prolonged latency to onset and results in cell death (cytolytic action). Free fatty acids in the membrane markedly affect CTX action. Melittin differences in their interactions with PLA2 and differences in effects on lipid metabolism in cell cultures. Bee venom and snake venom PLA2s differ markedly in their interactions ... |
|
| Mode of Action of Membrane Perturbing Agents: Snake Venom Cardiotoxins and Phospholipases A |
15 JUN 90 |
47 pages |
| Authors:
Jeffrey E. Fletcher; HAHNEMANN UNIV SCHOOL OF MEDICINE PHILADELPHIA PA
|
| Cardiotoxins (CTXs) and melittin are potent membrane perturbing agents that interact in mutual synergism with phospholipase A2 (PLA2). The present studies support the hypothesis that there is a hemolytic component of at least one of the CTXs not dependent on PLA2 activity, but that is enhanced by PLA2 contamination. Melittin and CTX elevate levels of diglycerides in airway epithelial cells (melittin) and skeletal muscle (melittin, CTX). The effects of CTX ... |
|
| Two-Dimensional Electrophoretic Analysis of Subcellular Liver Fractions and Isolated Hepatocytes from Normal and PFDA Treated Rats |
28 MAY 90 |
18 pages |
| Authors:
Frank A. Witzmann; INDIANA UNIV AT BLOOMINGTON DEPT OF BIOLOGY
|
| Perfluoro-n-decanoic acid (PFDA) effects on protein expression in the rat liver was studied following in vivo exposure to PFDA's LD50 and a lesser dose. Two-dimensional protein patterns were resolved on polyacrylamide gels for whole liver homogenate, mitochondrial, microsomal, cytosolic, and isolated hepatocyte protein fractions. PFDA exposure caused the deletion and induction of numerous proteins often in a dose related manner. Several proteins have been associated with those involved in lipid ... |
|
| United States Air Force Research Initiation Program for 1988. Volume 4 |
APR 90 |
990 pages |
| Authors:
Rodney C. Darrah; Claude Cavender; UNIVERSAL ENERGY SYSTEMS INC DAYTON OH
|
| Partial contents: Auditory modeling; Assessing the cognitive demands of tracking strategies; Optimization of the nonlinear discrete parameter model of the seated human spine; In vitro modeling of perfluoro-N-decanoate effects on enzymes of fatty acid metabolism; Investigation of training content validity and training efficiency in the Air Force airmen basic-in-residence training course; Intelligent tool to facilitate development of qualitative process models in novice programmers; Effect of range restriction on correlation coefficient ... |
|
| Gordon Research Conference on Lipid Metabolism Held in Meriden, New Hampshire on 17-21 June 1985 |
DEC 85 |
|
| Authors:
Richard E. Pagano; CARNEGIE INSTITUTION OF WASHINGTON BALTIMORE MD
|
| The Gordon Research Conference on Lipid Metabolism covered the following major topics: physical chemistry of lipids, enzymological aspects of lipid metabolism, metabolism of inositol lipids, lipid transfer between membranes, lipid translocation in cells, ether lipids, liposomes and anti-lipid antibodies, and glycolipids/sphingolipids. |
|
| USSR Report, Space Biology and Aerospace Medicine, Vol. 19, No. 4, July-August 1985 |
04 NOV 1985 |
156 pages |
| Authors:
JOINT PUBLICATIONS RESEARCH SERVICE ARLINGTON VA
|
|
| USSR Report, Life Sciences, Biomedical and Behavioral Sciences |
20 AUG 1985 |
89 pages |
| Authors:
JOINT PUBLICATIONS RESEARCH SERVICE ARLINGTON VA
|
|
| Relationship between Organophosphate Toxicity and Choline Metabolism |
15 MAR 85 |
|
| Authors:
Lynn Wecker; LOUISIANA STATE UNIV MEDICAL CENTER NEW ORLEANS
|
| The main objective of the research was to continue studies characterizing the effects of the organophosphates on the metabolism of choline- containing compounds in rat brain. Both in vitro and in vitro studies were conducted using brain tissue and whole animals. Studies investigating the actions of the organophosphates on choline levels in brain have indicated that the effects of sarin and soman differ from those of DFP and Paraoxon. Immediately ... |
|
| USSR Report, Space Biology and Aerospace Medicine, Volume 18, No. 4, July-August 1984 |
02 OCT 1984 |
143 pages |
| Authors:
JOINT PUBLICATIONS RESEARCH SERVICE ARLINGTON VA
|
|
| In Vitro Glucose Metabolism in the Epidermis and Dermis of the Pig |
NOV 1982 |
22 pages |
| Authors:
George J. Klain; Stephanie J. Barnhart; Walter G. Bell; Jorge Palafox; LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA
|
| Glucose metabolism was studied in skin slices prepared with a dermatome and obtained from the mid-lumbar region of young pigs. The first slice, comprising the epidermis was 0.1 micron thick, whereas all subsequent slices were prepared from the dermis and were 0.2 micron thick. Each precooled slice was incubated for 2 hours at 37 degrees in a Dubnoff metabolic incubator in 3 ml of Krebs-Ringer buffer containing 30 micromoles glucose ... |
|
| Protein Sparing Therapy during Pneumococcal Sepsis in Rhesus Monkeys. |
25 APR 1978 |
|
| Authors:
Robert W. Wannemacher Jr.; Mitchell V. Kaminski Jr.; Harold A. Neufeld; Richard E. Dinterman; Karen A. Bostian; ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FREDERICK MD
|
| A model was developed in the rhesus monkey to determine if the marked wasting of body proteins associated with sepsis could be prevented by an intravenous supply of various nutritional substrates. All monkeys were given a basic infusion of 0.5 g of amino acid nitrogen/kg body weight via an indwelling catheter in the jugular vein. Three groups were given either no added calories, 85 cal/kg from dextrose, or 85 calories ... |
|
| Microwave Magic. |
17 NOV 1977 |
|
| Authors:
John B. Bateman; OFFICE OF NAVAL RESEARCH LONDON (ENGLAND)
|
| This is a report, with critical comment, of a meeting convened by a microwave research department within the French National Research Center for Space and Aeronautics in order to present the results of current French research on the biological effects of microwaves. The report proper is preceded by notes on the sponsoring organizations and by critical remarks on a series of papers describing the remarkable biological properties of the physically ... |
|
| Synthetic Analogs of Phospholipid Metabolites as Antimalarials. |
28 SEP 1977 |
|
| Authors:
Arthur F. Rosenthal; LONG ISLAND JEWISH-HILLSIDE MEDICAL CENTER NEW HYDE PARK NY
|
| Initial year's progress is described toward the synthesis of analogs of phospholipids and of their biosynthetic intermediates as possible antimalarials of a new type. Emphasis was placed on phosphonic and phosphinic acid analogs of lecithin, phosphatidic acid, cytidine diphosphate diglyceride, and cytidine diphosphate choline. Nine compounds were submitted of which one was a major target and three were secondary target compounds. None of the substances so far tested showed appreciable ... |
|
| The Importance of Prophylatic Vitaminization of the Diet of Persons under Emotional Stress at Work, for Normalization of Changes in Lipoid Metabolism, |
JAN 1974 |
|
| Authors:
Yu. F. Udalov; B. N. Garashov; N. N. Bakhtadze; ARMY FOREIGN SCIENCE AND TECHNOLOGY CENTER CHARLOTTESVILLE VA
|
| The effect of A, B, B2, PP and C vitamins on lipoid and protein metabolism was studied in normal persons and patients in the initial stages of atherosclerosis. Blood cholesterol, lecithin, alpha and beta-lipoprotein levels and the blood serum albumin and globulin content were all determined. All of the 231 persons examined were subject to substantial nervous and emotional stress in their work. Positive shifts in lipoid and protein metabolism ... |
|
| On Diet Therapy in Atherosclerosis -USSR- |
27 JAN 1961 |
17 pages |
| Authors:
F. K. Men'shikov; JOINT PUBLICATIONS RESEARCH SERVICE ARLINGTON VA
|
| The observations of morphologists, clinicians, biochemists, researcher, and dietidans are utilized in diet formation for those afflicted with atherosclerosis. |
|
Reports by Keyword(s)
LIPID METABOLISM
