| Screening for Inhibitors of Essential Leishmania Glucose Transporters |
Jul 2012 |
11 pages |
| Authors:
Scott M Landfear; OREGON HEALTH AND SCIENCES UNIV PORTLAND
|
 | The major objective of this project is to identify compounds that function as selective inhibitors of the essential glucose transporters of the parasite Leishmania mexicana. To identify such compounds, a cell growth assay was developed that can be employed in a high-throughput screen (HTS) for such inhibitors. This assay was employed in a scaling screen of the 2000 compound MicroSource Discovery Spectrum Collection and of the 600,000 compound CBT library ... |
|
| CAPA-Gene Products in the Haematophagous Sandfly Phlebotomus papatasi (Scopoli) - Vector for Leishmaniasis Disease |
Jan 2012 |
8 pages |
| Authors:
Reinhard Predel; Susanne Neupert; William K Russell; Frank Hauser; David H Russell; Andrew Li; Ronald J Nachman; TEXAS A AND M UNIV COLLEGE STATION DEPT OF CHEMISTRY
|
| Sandflies (Phlebotominae, Nematocera, Diptera) are responsible for transmission of leishmaniasis and other protozoan-borne diseases in humans, and these insects depend on the regulation of water balance to cope with the sudden and enormous intake of blood over a very short time period. The sandfly inventory of neuropeptides, including those that regulate diuretic processes, is completely unknown. Direct MALDI-TOF/TOF mass spectrometric analysis of dissected ganglia of Phlebotomus papatasi, combined with a ... |
|
| Cutaneous Leishmaniasis |
JUN 2011 |
18 pages |
| Authors:
Alan J. Magill; Wayne M. Meyers; Ronald C. Neafie; Mary K. Klassen-Fischer; UNIFORMED SERVICES UNIV OF THE HEALTH SCIENCES BETHESDA MD
|
| The cutaneous leishmaniases include a spectrum of self healing and chronic disease forms caused by protozoan parasites of the genus Leishmania. Clinical presentations differ according to parasite burden and host immune response. Although there can be considerable overlap of clinical presentations, 5 distinct cutaneous syndromes are recognized in Leishmania infections: 1) simple or localized ulcerative or nodular cutaneous leishmaniasis (CL); 2) mucosal leishmaniasis (ML); 3) leishmaniasis recidivans (LR); 4) diffuse ... |
|
| Visceral Leishmaniasis |
JUN 2011 |
12 pages |
| Authors:
Alan J. Magill; Wayne M. Meyers; Mary K. Klassen-Fischer; Ronald C. Neafie; UNIFORMED SERVICES UNIV OF THE HEALTH SCIENCES BETHESDA MD
|
| Visceral leishmaniasis (VL), a chronic disease caused by parasites of the Leishmania donovani complex, is characterized by irregular fever, enlargement of the spleen and liver, weight loss, pancytopenia, and hypergammaglobulinemia. |
|
| Research to Develop Biomedical Applications of Free Electron Laser Technology |
31 MAR 2011 |
48 pages |
| Authors:
Rox Anderson; Michael Hamblin; Tayyaba Hasan; Irene Kochevar; Charles Lin; MASSACHUSETTS GENERAL HOSPITAL BOSTON WELLMAN LABS OF PHOTOMEDICINE
|
| The overall goal is to solve substantial military medical problems by creating technologies that are useful to diagnose and care for soldiers, and by elucidating the mechanisms of organ trauma and diseases that particularly affect soldiers. To achieve this broad goal, we have undertaken projects focused on novel treatments of infectious diseases and physical trauma relevant to military personnel, technological improvements for trauma care, and new approaches to triage. Infectious ... |
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| Evaluation of a Metofluthrin Fan Vaporizer Device Against Phlebotomine Sand Flies (Diptera: Psychodidae) in a Cutaneous Leishmaniasis Focus in the Judean Desert, Israel |
Mar 2011 |
10 pages |
| Authors:
Gabriela Zollner; Laor Orshan; WALTER REED ARMY INST OF RESEARCH SILVER SPRING MD DEPT OF ENTOMOLOGY
|
| The OFF! Clip-On fan vaporizer device releasing metofluthrin was evaluated against phletobomine sand flies in the Judean Desert, Israel, in October, 2009. A total of 76,400 sand flies was collected, with male flies representing 98.3% Phlebotomus sergenti and 1.7% P. papatasi. Females comprised 43.0% of the total catch and included 6.7% blood-fed females. Similar proportions of flies were collected in both suction and sticky traps. In trials with unbaited suction ... |
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| Evaluation of Juvenile Hormone Analogues as Rodent Feed-Through Insecticides for Control of Immature Phlebotomine Sandflies |
Jan 2011 |
6 pages |
| Authors:
T M Mascari; M A Mitchell; E D Rowton; L D Foil; WALTER REED ARMY INST OF RESEARCH SILVER SPRING MD
|
| The juvenile hormone analogues methoprene and pyriproxyfen were evaluated as rodent feed-through insecticides for control of immature stages of the sandfly Phlebotomus papatasi Scopoli (Diptera: Psychodidae). The development and survival of P. papatasi second-instar larvae fed faeces from Syrian hamsters Mesocricetus auratus, that had been fed a diet containing methoprene (0, 9.788 97.88 or 978.8 p.p.m.) or pyriproxyfen (0, 9.82, 98.2 or 982 p.p.m.) were evaluated. The faeces of methoprene-treated ... |
|
| The Role of the United States Military in the Development of Vector Control Products, Including Insect Repellents, Insecticides, and Bed Nets |
Jun-2009 |
13 pages |
| Authors:
Russell E Coleman; Lynn W Kitchen; Kendra L Lawrence; MILITARY INFECTIOUS DIESEASES RESEARCH PROGRAM FORT DETRICK MD
|
| Arthropod-borne diseases such as malaria, dengue, scrub typhus, and leishmaniasis continue to pose a significant threat to U.S. military forces deployed in support of operational and humanitarian missions. These diseases are transmitted by a variety of arthropods, including mosquitoes, ticks, chiggers, sand flies, and biting midges. In addition to disease threats, biting arthropods can cause dermatitis, allergic reactions, and sleep loss; therefore, monitoring of vector impact and integrated use of ... |
|
| The Deployed Warfighter Protection Research Program: Finding New Methods to Vanquish Old Foes (The United States Army Medical Department Journal, April-June 2008) |
Jun-2008 |
14 pages |
| Authors:
Stanton E Cope; Daniel A Strickman; Graham B White; Kathleen N Dunemn; ARMED FORCES PEST MANAGEMENT BOARD WASHINGTON DC
|
| The Deployed Warfighter Protection research program (DWFP) is an initiative to develop and validate novel methods to protect United States military deployed abroad from threats posed by disease-carrying insects. Vector-borne diseases such as malaria, dengue, leishmaniasis, and chikungunya are among the most important health risks facing deployed troops. There are no vaccines for many diseases transmitted by biting insects, so methods in insect management and control, as well as personal ... |
|
| Evaluation of Novaluron as a Feed-Through Insecticide for Control of Immature Sand Flies (Diptera: Psychodidae) |
Jul-2007 |
5 pages |
| Authors:
T M Mascari; M A Mitchell; E D Rowton; L D Foil; WALTER REED ARMY INST OF RESEARCH SILVER SPRING MD DEPT OF ENTOMOLOGY
|
| The development and survival of sand fly Phlebotomus papatasi Scopoli (Diptera: Psychodidae) larvae fed feces of Syrian hamsters, Mesocricetus auratus, that had been fed a diet containing novaluron were evaluated. In total, six larval diets were used in sand fly larval bioassays. Four groups of larvae were fed feces of hamsters that had been maintained on a diet containing either 0,9.88, 98.8, or 988 ppm novaluron. Two additional groups were ... |
|
| Sterilization of Medical Instruments |
06 MAY 2007 |
24 pages |
| Authors:
Joseph Birmingham; Mary Moore; Robert Moore; MICROENERGY TECHNOLOGIES INC VANCOUVER WA
|
| A need exists for a portable sterilization system that can quickly sterilize skin for possible use with medical instruments and skin catheters. To address this challenge, MicroStructure Technologies (MicroST) is developing an atmospheric pressure nonthermal plasmas for rapid deactivation of cells and bacterial spores on surfaces. For example, the lethal Ames strain of Bacillis anthrocis has been deactivated after a minute of ionized gas exposure. The objective of this DARPA ... |
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| Laboratory Evaluation of Diflubenzuron as a Feed-Through for Control of Immature Sand Flies (Diptera: Psychodidae) |
Mar-2007 |
5 pages |
| Authors:
T M Mascari; M A Mitchell; E D Rowton; L D Foil; LOUISIANA STATE UNIV BATON ROUGE AGRICULTURAL CENTER
|
| The benzoylurea chitin synthesis inhibitor diflubenzuron was evaluated as a rodent feed-through for the control of immature stages of Phlebotomus papatasi Scopoli (Diptera: Psychodidae). The development and survival of second instars of P. papatasi larvae that were fed feces from Syrian hamsters, Mesocricetus auratus, that had been fed a diet containing 0, 8.97, 89.7, or 897 ppm diflubenzuron was evaluated. No pupation or adult emergence occurred when larvae were fed ... |
|
| Medical Surveillance Monthly Report (MSMR). Volume 13, Number 2, February/March 2007 |
Mar-2007 |
29 pages |
| Authors:
ARMED FORCES HEALTH SURVEILLANCE CENTER SILVER SPRING MD
|
| This is the 100th issue of the Medical Surveillance Monthly Report (MSMR). Since the first issue was published in April 1995, there has been a steady stream of unimaginable events with profound military medical significance, including the initiation and conduct of U.S. military operations in the Balkans; terrorist attacks on the United States (including the Pentagon) on 11 September 2001; the initiation and conduct of the global war on terrorism; ... |
|
| Zinc: An Essential Trace Element with Potential Benefits to Soldiers |
DEC 2005 |
6 pages |
| Authors:
James P. McClung; Angus G. Scrimgeour; ARMY RESEARCH INST OF ENVIRONMENTAL MEDICINE NATICK MA MILITARY NUTRITION DIV
|
| Zinc is a trace element known to be an essential nutrient for life. It functions as a cofactor for numerous enzymes, including those involved in DNA and RNA replication and protein synthesis. Soldiers represent a unique population faced with intense metabolic and mental demands as well as exposure to various immune challenges. Some of these factors may affect their dietary zinc requirements. Although severe zinc deficiency is unlikely to occur, ... |
|
| Military-Relevant Infectious Diseases Endemic to Kenya: Epidemiology, Immunology, Pathophysiology, Treatment, and Prevention |
MAR 2005 |
29 pages |
| Authors:
Davy K. Koech; KENYA MEDICAL RESEARCH INST NAIROBI
|
| The mission of USAMRU-K is to develop and test improved products for the diagnosis, treatment and prevention of infectious disease threats to deployed service members. Surveillance activities are also conducted to identify and develop response strategies for global emerging infections with a potential to impact readiness, mission accomplishment, or homeland security. These activities are undertaken in research laboratories and field stations in locations where malaria, HIV/AlDS, leishmaniasis, West Nile virus, ... |
|
| Clinical Use of Plasma and Plasma Fractions Chapter: Viral Inactivation Techniques |
26 JAN 2005 |
26 pages |
| Authors:
Joesph P. Pelletier; YALE UNIV NEW HAVEN CT
|
| Even though the blood supply is very safe, concerns regarding transmission of transfusion-related pathogens exist. Risks are reduced by donor screening, arm-preparation techniques, first aliquant diversion, screening for pathogens and, in many countries, pathogen reduction/eradication technology. The risk for viral infection from transfusion is now reported at 1:2,135,000 for HIV, 1:138,700-233,000 for HBV, 1:1935,000 for HCV, 1:250,000 for HTLV 1 and 2 (after screening peripherally), 1:1,000,000 HAV, 1:10,000 for parvovirus ... |
|
| The Associate Program on Ethnobiology, Socio-Economic Value Assessment and Community Based Conservation |
OCT 2001 |
44 pages |
| Authors:
Maurice M. Iwu; BIORESOURCES DEVELOPMENT AND CONSERVATION PROGRAMME SILVER SPRING MD
|
| In collaboration with the Smithsonian Institution BDCP conducted training courses in Nigeria and Cameroon on biodiversity assessment and monitoring and an adaptive management workshop in Nigeria. Four I ha biodiversity plots were also established. In the drug discovery component sixty plant extracts were processed and 12 compounds isolated from plants need in African traditional medicine as antimalaria. The following plants were bulk- extracted at InterCEDD Nsukka, Nigeria: Aspilia Africana, Chamaecrista ... |
|
| Emerging Diseases Surveillance in East Africa |
AUG 2001 |
11 pages |
| Authors:
Davey K. Koech; KENYA MEDICAL RESEARCH INST NAIROBI
|
| Since the inception of USAMRU-K in 1969, its activities have centered on the epidemiology, entomology and immunology of the diseases endemic to Kenya, in particular, trypanosomaisis, malaria, leishmaniasis, rift valley fever, and enteric pathogens. Clinical studies to test the safety and efficacy of new drugs and vaccine candidates have also been undertaken primarily at the Kisumu field site. Even though the potential for disease surveillance has been evident, a systematic ... |
|
| Evaluation of Antileishmanial Drugs in Animal Models |
MAR 2000 |
39 pages |
| Authors:
William L. Hanson; GEORGIA UNIV RESEARCH FOUNDATION INC ATHENS
|
| A total of 34 selected compounds, including natural products, some compounds known to be efficacious against other diseases, cholesterol lowering drugs currently in use in human beings, and pro drugs of the pentamidine type were studied in hamsters at various dosage levels, via various routes and treatment schedules for antileishmanial efficacy against Leishmania (leishmania) donovani. One of the same compounds (Baycol) was studied for efficacy against ... |
|
| New Drugs and Drug Resistance in Malaria: Molecular Genetic Analysis |
JAN 98 |
|
| Authors:
Dyann F. Wirth; HARVARD COLL CAMBRIDGE MA
|
 | Drug resistance has emerged as a major problem in the treatment of all microbial agents and in many cancer chemotherapies. Drug resistance has become particularly acute in malaria where resistance to chloroquine, the cheapest and most efficacious antimalaria has spread throughout the endemic parts of the world and resistance to other antimalarials is rapidly developing and spreading. The goal of this work is to understand the mechanism of drug resistance ... |
|
| Biochemistry and Chemotherapy of Malaria and Leishmaniasis |
DEC 97 |
34 pages |
| Authors:
Linda Nolan; MASSACHUSETTS UNIV AMHERST
|
| Malaria is the world's most ravaging infectious disease. It is rampant throughout much of the tropics and some of the temperate areas of the world. It threatens a third of the world's population, presently afflicting hundreds of millions of people, causing several million deaths annually and possibly generating as many as 92 million new clinical cases each year. The socioeconomic drain of the disease is enormous. Resurgence of this pestilence ... |
|
| Evaluation of Potential Antileishmanial Drugs in Animal Models |
APR 97 |
24 pages |
| Authors:
William L. Hanson; GEORGIA UNIV RESEARCH FOUNDATION INC ATHENS
|
| A total of 16 selected compounds which included some natural products as well as drugs known to be efficacious against other diseases were studied at various dosage levels and via various routes of administration in hamsters for antileishmanial efficacy against visceral leishmaniasis (Leishmania Leishmania donovani) and three of the same compounds were studied for activity against cutaneous leishmaniasis (Leishmania Vianni panamensis). None of these were efficacious against either leishmania but ... |
|
| Drug Development and Conservation of Biodiversity in West and Central Africa |
AUG 96 |
24 pages |
| Authors:
Maurice M. Iwu; BIORESOURCES DEVELOPMENT AND CONSERVATION PROGRAMME SILVER SPRING MD
|
| The report comprises of projects undertaken by the Bioresources Development and Conservation Programme (BDCP) in pursuant of the objectives of Associate Programs 2 and 5 of the ICBG project entitled Drug Development and Conservation of Biodiversity in West and Central Africa - for Year 2. The accomplishments include training of ethnobotanists, purchase and installation of equipment, and six ethnobotanic surveys which led to the identification of over 120 plants used ... |
|
| Topical Bibliography of Published Works Regarding the Health of Veterans of the Persian Gulf War. Revision 1 |
JUN 96 |
90 pages |
| Authors:
Colleen McDonough; Gregory C. Gray; NAVAL HEALTH RESEARCH CENTER SAN DIEGO CA
|
| The Recently, Persian Gulf War veteran research has captured national attention. Numerous federal and nonfederal researchers are currently conducting a wide array of investigations into reports that veterans of the Persian Gulf War are suffering increased morbidity. No list of published reference works is available. Due to increasing interest and the need to continue to compile relevant references for the Gulf War veteran investigators, we decided to maintain a master ... |
|
| Biochemistry and Chemotherapy of Leishmaniasis and Malaria |
DEC 1995 |
62 pages |
| Authors:
Linda Nolan; MASSACHUSETTS UNIV AMHERST
|
| Leishmaniasis, a disease caused by protozoan parasites of the Leishmania spp., is one of the major public health problems currently affecting humanity. Therapeutic agents for this disease are either ineffective or toxic. Malaria is considered to be the most important infectious disease of humans on a world-wide scale. The purpose of this work is to aid in the development of an effective, non-toxic treatment for leishmaniasis and malaria. The objective ... |
|
| Topical Bibliography of Published Works Regarding the Health of Veterans of the Persian Gulf War |
AUG 95 |
|
| Authors:
Colleen M. Cornellson; Gregory C. Gray; NAVAL HEALTH RESEARCH CENTER SAN DIEGO CA
|
| We have constructed a topical bibliography for the benefit of researchers conducting studies among Persian Gulf War veterans. The document was framed around a bibliography of the Persian Gulf War and associated topics that was prepared by Jacqueline Van de Kamp, M.L.S., Specialized Information Services, National Library of Medicine, and John H. Ferguson, M.D., Office of Medical Applications of Research, National Institutes of Health. Their document was generated in April ... |
|
| Research Programs in Tropical and Infectious Diseases |
26 JUL 95 |
331 pages |
| Authors:
Bryce Redington; Joe P. Bryan; Larry Laughlin; HENRY M JACKSON FOUNDATION ROCKVILLE MD
|
| Between December 1, 1989 and May 31, 1995 a number of research projects were accomplished in Belize. The area that was most thoroughly studied was that of hepatitis. In response to reports of a number of cases of hepatitis around a banana plantation in 1990. a serosurvey of workers and their families was conducted. This revealed that up to 70% of workers had been infected with hepatitis B and almost ... |
|
| Operation Desert Storm. Questions Remain on Possible Exposure to Reproductive Toxicants |
AUG 1994 |
39 pages |
| Authors:
Winslow Wheeler; Kurt Kroemer; Robert Coperland; Penny Pickett; Venkareddy CHennareddy; GOVERNMENT ACCOUNTABILITY OFFICE WASHINGTON DC
|
| Since their return from deployment in the Persian Gulf war, many U.S. troops have complained of health problems that they believe result from their service in the gulf region. Research has shown that U.S. troops were exposed before, during, and after the war to a variety of substances that are potentially hazardous. These include occupational hazards (such as the extensive use of diesel fuel as a sand suppressant in and ... |
|
| Arthropods: Vectors of Disease Agents |
JUL 1994 |
11 pages |
| Authors:
Chad P. McHugh; ARMSTRONG LAB BROOKS AFB TX OCCUPATIONAL AND ENVIRONMENTAL HEALTH DIRECTORATE
|
| This is the third and final article in a continuing education series on arthropods. The interactions between arthropods and the various etiologic agents they transmit are reviewed. The incidence of arthropod-borne diseases in the United States, the causative agents, and their reservoirs, vectors and transmission mechanisms are summarized in a Table. The ecology of five arthropod-borne diseases - Lyme disease, eastern equine encephalitis, plague, tularemia, and leishmaniasis - is discussed ... |
|
| JPRS Report, Epidemiology |
03 MAY 93 |
18 pages |
| Authors:
JOINT PUBLICATIONS RESEARCH SERVICE ARLINGTON VA
|
| Partial Contents: Cholera Outbreak in Busia District, Guinea Worm Eradication Proceeding Well, Eight Die From Yellow Fever in Oyo, Cholera Spread To All Parts of Country, Statistics on Cholera Deaths Issued, Anthrax Outbreak in West Contained,Ten Percent Are Hepatitis B Carriers, THE Cholera Under Control in Mashonaland Central, Cholera Epidemic Deaths 120 Thus Far, Refugee Camp Has High Cholera Death Rate, Fifty Thousand Hectares Infested With Armyworm,Viral Hepatitis at School,Water ... |
|
| Enzyme Polymorphism and Genetic Variability of One Colonized and Several Field Populations of Phlebotomus papatasi (Diptera: Psychodidae) |
1993 |
9 pages |
| Authors:
Hala A. Kassem; David J. Fryauff; Magdi G. Shehata; Bahira M. El Sawaf; NAVAL MEDICAL RESEARCH UNIT NO 3 FPO NEW YORK 09527
|
| The Alexandria laboratory colony and five field populations of Phlebotomus papatasi (Scopoli) from Egypt were analyzed for genetic variation at 17 enzyme loci. The laboratory colony was characterized by a low level of genetric variation as measured by the average number of alleles per locus (A = 1.70 + or - 0.16) and the average expected heterozygosity (He = 0.06 + or - 0.02 ). Polymorphism was observed at 23.5% ... |
|
| Research Program In Tropical Infectious Diseases |
15 DEC 91 |
78 pages |
| Authors:
Bryce C. Redington; HENRY M JACKSON FOUNDATION ROCKVILLE MD
|
| Research progressed on the causes of fevers of unknown origin, leishmaniasis and mosquito larval ecology. New initiatives included investigations of outbreaks of hepatitis and gastroenteritis. Manuscripts on gastroenteritis and hepatitis were-prepared and submitted for presentation and publication. Suspected cases of tick-borne fever in an archaeological team were investigated. Five USUHS medical students conducted research and obtained clinical experience in Belize. Three Belizean physicians entered USUHS MPH and MTM and H ... |
|
| Malaria, Leishmaniasis and Shistosomiasis Vector Ecology, Transmission, Immunology and Prophylaxis in Kenya |
06 NOV 91 |
18 pages |
| Authors:
Davy K. Koech; KENYA MEDICAL RESEARCH INST NAIROBI
|
| A malaria vaccine evaluation site at Saradidi, Kenya, has been characterized for epidemiological, entomological and demographic parameters over a two year period. The transmission of flaciparum malaria by Anopheles gambiae s.l. and A. funestus was found to be intense year-round. An evaluation of a WRAIR-developed malaria sporozoite vaccine, R32ToxA, was begun in April, 1990, with 38 pairs of volunteers. Leishmaniasis studies have described several parasite-vector-host relationships previously unreported in East ... |
|
| Chemotherapy and Drug Targeting in the Treatment of Leishmaniasis |
29 MAY 91 |
45 pages |
| Authors:
Linda L. Nolan; MASSACHUSETTS UNIV AMHERST
|
| Leishmaniasis, a disease caused by protozoan parasites of the Lesihsmania spp., is one of the major public health problems currently affecting humanity. Therapeutic agents for this disease is either ineffective or toxic. The purpose of this work is to aid in the development of an effective, non-toxic treatment for leishmaniasis. The objective of this research was to isolate and characterize unique leishmanial enzymes (DNA polymerase and S- adenosylsynthetase) for the ... |
|
| Placebo-Controlled Clinical Trial of Sodium Stibogluconate (Pentostam) vs. Ketoconazole for Treating Cutaneous Leishmaniasis in Guatemala |
23 APR 91 |
22 pages |
| Authors:
Thomas R. Navin; CENTERS FOR DISEASE CONTROL ATLANTA GA DIV OF PARASITIC DISEASES
|
| To determine the relative efficacy and toxicity of stibogluconate and ketoconazole for the treatment of cutaneous leishmaniasis, we conducted a comparative trial in which 120 Guatemalan men with parasitologically proven cutaneous leishmaniasis were randomly divided into three treatment groups: sodium stibogluconate (20 mg of antimony per kg per day intravenously for 20 days); ketoconazole (600 mg per day orally for 28 days); and placebo. Stibogluconate was associated with occasional moderate ... |
|
| Epidemiology and Control of Malaria, Leishmaniasis and Schistosomiasis in Brazil |
15 FEB 91 |
30 pages |
| Authors:
Aluizio R. Prata; Patrick B. McGreevy; Terry A. Klein; Norman E. Peterson; BRASILIA UNIV (BRAZIL)
|
| Human malaria in Brazil is caused by Plasmodium falciparum and Plasmodium vivax. The incidence of malaria cases reported from the Amazon Basin is increasing yearly due, in part, to the influx of colonists and miners from other regions of Brazil. Control measures currently in use are ineffective and little is known about the biology and primary vector of both species of malaria in the Costa Marques, Rondonia area, and other ... |
|
| Research Program in Tropical Infectious Diseases |
14 DEC 90 |
91 pages |
| Authors:
Bryce C. Redington; Jose A. Lopez; Llewellyn J. Legters; Richard E. Krieg; HENRY M JACKSON FOUNDATION ROCKVILLE MD
|
| The Memorandum of Understanding between the Ministry of Health of Belize and USUHS was signed in December 1989. Two USUHS MTM&H students conducted research and obtained clinical experience in country. In August 1990, Jorge Palanco, MD received the MPH from USUHS. The renovation of the CML was completed in October 1990. The dedication of the CML and the ERC took place in November 1990. The preliminary analysis of the sera ... |
|
| Research on Defense Against the Effects of Parasitic Disease. Pilot Study on the Efficacy of Pentostam in the Treatment of Mucocutaneous Leishmaniasis (MCL) |
01 NOV 90 |
17 pages |
| Authors:
Rolando E. Saenz; GORGAS MEMORIAL INST OF TROPICAL AND PREVENTIVE MEDICINE INC BETHESDA MD
|
| A study to determine the value of intravenous administration of sodium stibogluconate (Pentostam) for treatment of mucocutaneous leishmaniasis, involved 16 patients, 9 females and 7 males. The dose was 20 mg/kg body weight for 28 days. Thirteen patients completed the full course, while in 3 treatment was interrupted due to adverse side effects, such as cardiac alterations, elevation of transaminases, vomiting, arthralgias and myalgias. Of the 13 patients who completed ... |
|
| Chemotherapy and Drug Targeting in the Treatment of Leishmaniasis |
30 MAY 90 |
79 pages |
| Authors:
Linda L. Nolan; MASSACHUSETTS UNIV AMHERST
|
| Leishmaniasis, a disease caused by protozoan parasites of the Leishmania spp., is one of the major public health problems currently affecting humanity. Therapeutic agents for this disease is either ineffective or toxic. The purpose of this work is to aid in the development of an effective, non-toxic treatment of leishmaniasis. The objectives of this research are the following: (1) To isolate and characterize unique leishmanial enzymes (DNA polymerase and S-adenosylsynthetase) ... |
|
| Evaluation of Sodium Stibogluconate (Pentostam) and Ketoconazole in the Treatment of American Cutaneous Leishmaniasis |
16 APR 90 |
48 pages |
| Authors:
Thomas R. Navin; CENTERS FOR DISEASE CONTROL ATLANTA GA DIV OF PARASITIC DISEASES
|
| Guatemalans with parasitologically proven cutaneous leishmaniasis were randomly and equally divided into 3 treatment groups: those receiving sodium stibogluconate (Pentostam), 20 mg antimony/kg/day iv for 20 days; those receiving ketoconazole (600 mg/day po for 28 days; and those receiving placebo treatment. All patients tolerated the treatments well with the exception of 2 patients in the ketoconazole group who prematurely stopped their medication; 1 developed abdominal pain and nausea and the ... |
|
| Leishmaniasis in Texas: Isolation of Leishmania mexicana from Neotoma Micropus |
90 |
10 pages |
| Authors:
Chad P. McHugh; Max Grogl; Sara F. Kerr; SCHOOL OF AEROSPACE MEDICINE BROOKS AFB TX
|
| A female Neotoma micropus infected with Leishmania was collected in Zavala County, Texas, on January 15, 1990. The infection was limited to lesions at the bases of the ears, and the parasite grew readily in Schneider's Drosophila medium supplemented with 20% fetal bovine serum. Isozyme analysis determined the parasite to be L. mexicana. Keywords: Parasitic diseases. (kr) |
|
| Chemotherapy and Drug Targeting in the Treatment of Leishmaniasis |
30 MAY 89 |
91 pages |
| Authors:
Linda L. Nolan; MASSACHUSETTS UNIV AMHERST
|
| Leishmaniasis, a disease caused by protozoan parasites of the Leishmania spp., is one of the major public health problems currently affecting humanity. Therapeutic agents for this disease is either ineffective or toxic. The purpose of this work is to aid in the development of an effective, non-toxic treatment for leishmaniasis. The objectives of this research were the following: (1) To develop a reliable in vitro method for measuring the potential ... |
|
| Synthesis of Improved Antileishmanial and Antitrypanosomal Drugs, Treatment and Prophylaxis |
APR 89 |
|
| Authors:
A. Markovac; D. J. Dagli; A. B. Ash; C. L. Stevens; ASH STEVENS INC DETROIT MI
|
| The work reported herein was directed at the preparation of improved antileishmanial and antitrypanosomal drugs. During the contact period (forty six months), 46 candidate drugs were submitted for biological testing. This program was divided into five phases of work: (1) Analogs of WR 6026 (eleven); (2) Potential metabolites and analogs of a known metabolite WR 6026 (seven); (3) Bis-amidoxime and bis-amidines (four); (4) Dimethylaminomethyl ethylenes (similar to Burroughs Welcome 353 ... |
|
| JPRS Report, Epidemiology |
21 MAR 1989 |
22 pages |
| Authors:
JOINT PUBLICATIONS RESEARCH SERVICE ARLINGTON VA
|
| Partial Contents: AIDS, Blood Transfusion, Death, Medical Support, Life Insurance, Drugs, Gonorrhea, Influenza, Pregnant WOmen, Infectious Diseases, Leishmaniasis, Streptococcus, Prostitutes, Veneral Diseases. |
|
| United States Army Medical Materiel Development Activity |
10 MAR 89 |
58 pages |
| Authors:
Carl E. Pedersen Jr; ARMY MEDICAL MATERIEL DEVELOPMENT ACTIVITY FORT DETRICK MD
|
| The Annual Report, Calendar Year 1988, summarizes development projects monitored by the U.S. Army Medical Materiel Development Activity in projects authorized by the Surgeon General, the Army, and the Commander, U.S. Army Medical Research and Development Command, and supported by RDTE funds from the U.S. Army Medical Research and Development Command. Keywords: Logistics; Medical materiel; Acquisition; Vaccines; Hemorrhagic fevers; Hepatitis; Antimalarials; Monoclonal antibodies; Prophylaxis; Chemotherapeutic agents; Schistosomiasis; Leishmaniasis. (kt) ... |
|
| Synthesis of Improved Antileishmanial and Antitrypanosomal Drugs Treatment and Prophylaxis |
MAR 89 |
|
| Authors:
A. Markovac; D. J. Dagli; A. B. Ash; C. L. Stevens; ASH STEVENS INC DETROIT MI
|
| During the current reporting period this program was directed at the preparation of improved antileishmanial drugs based on the identification of two metabolites of the highly-active antileishmanial drug 8-(6- diethylaminohexylamino)-6-methoxy-4-methlquinoline, WR 6026. Ten compounds were synthesized and limited test data against visceral leishmaniasis in the hamster is reported. The first metabolite was the 4-hydroxymethyl derivative of WR 6026. The second metabolite was the 8-(6-ethylaminohexyl)amino derivative of WR 6026. Ten analogs ... |
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| Chemotherapy of Leishmania with Oligodeoxynucleotide Probes |
14 FEB 89 |
13 pages |
| Authors:
Rich B. Meyer Jr; MICROPROBE CORP BOTHELL WA
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| The goal of this project has been to investigate the potential of antisense oligonucleotides to kill Leishmania enriettii cells in culture. These antisense oligonucleotides are directed against the 35-base leader sequence spliced to the 5'-end of all Leishmania mRNA, with the objective of achieving cell kill by arresting translation. Agents that successfully arrested growth or killed the parasites in vitro would be viable candidates for study in animal models for ... |
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| Chemotherapy and Drug Targeting in the Treatment of Leishmaniasis |
30 JUN 88 |
44 pages |
| Authors:
Linda L. Nolan; MASSACHUSETTS UNIV AMHERST
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| Leishmaniasis, a disease caused by protozoan parasites of the Leishmania spp., is one of the major public health problems currently affecting humanity. Therapeutic agents for this disease is either ineffective or toxic. The purpose of this work is to aid in the development of an effective, nontoxic treatment for leishmaniasis. The objective of this research was to isolate and characterize unique leishmanial enzymes (DNA polymerase) and to test promising antileishmanial ... |
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| In vitro and In vivo Studies for Development of a Leishmaniasis Vaccine |
01 AUG 87 |
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| Authors:
David J. Wyler; TUFTS UNIV BOSTON MA SCHOOL OF MEDICINE
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| The goal of this Contract is to identify antigens of Leishmania that could serve as candidates for an antileishmanial vaccine. To accomplish this goal, monoclonal antibodies against Leishmania major promastigotes have been developed as analytic and preparative reagents. In the second year of Contract (covered by this report) we prepared 11 additional monoclonal antibodies (all IgC3) and expanded 4 in ascites. We used immunoprecipitation of metabolically labeled promastigote antigens and ... |
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| Clinical Pharmacology Studies. Phase 1 |
15 APR 87 |
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| Authors:
Paul S. Lietman; Brent G. Petty; David M. Kornhauser; JOHNS HOPKINS UNIV BALTIMORE MD DIV OF CLINICAL PHARMACOLOGY
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| The scientific work of this year centered around the bioavailability, safety, tolerance, pharmacokinetics and pharmacodynamics of pyridostigmine; and the absorption, safety, tolerance and pharmacokinetics of single doses of WR 6026. These two studies were completed successfully and efficiently, and complete details can be found in the draft Task Reports which have been submitted. These drafts are in the process of review and revision by Division of Experimental Therapeutics personnel prior ... |
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Reports by Keyword(s)
LEISHMANIASIS
