| Summary: Disabled Submarine Heat Stress Conference |
11-Sep-2009 |
14 pages |
| Authors:
Wayne G Horn; NAVAL SUBMARINE MEDICAL RESEARCH LAB GROTON CT
|
 | This document summarizes the Disabled Submarine Heat Stress Conference that was held at the Naval Submarine Medical Research Laboratory, Groton, Connecticut, on 22 June 2004. In the discussion of heat stress measurement, the consensus of the panel was that standard wet globe bulb temperature devices were not needed in DISSUB conditions, since radiation (no solar load) was not a significant factor. In DISSUB conditions only two factors need determination: ambient ... |
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| Novel Magnetic Fluids for Breast Cancer Therapy |
01-Jan-2008 |
12 pages |
| Authors:
Konstanty Mazuruk; ALABAMA UNIV IN HUNTSVILLE
|
| The research goal of this project was to develop a novel class of magnetic fluids that exhibit thermo-regulating properties attractive for a number of medical applications. These fluids could potentially surpass the functionality of currently available magnetic fluids used in hyperthermia A A novel class of nano-particles has been discovered that possesses an inherent self-limiting mechanism against overheating and it utilizes a different physical principle than the Curie point based ... |
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| Novel Magnetic Fluids for Breast Cancer Therapy |
01 APR 2007 |
22 pages |
| Authors:
Konstanty Mazuruk; ALABAMA UNIV IN HUNTSVILLE
|
| The extended project dealt with the characterization of magnetic nano-colloids prepared by wet chemical process using FTIR absorption spectroscopy FTIR indicated that the nano-particles were more likely made of Fe3O4. New method and apparatus was developed for laser spark milling of magnetic micro-powders into nano-powders Two compounds were tested: Fe2O3:TiO2:MgO water and MnAs in water/alcohol In both cases nano-colloids were made out of micro-powder suspensions. Provisional patent application has been ... |
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| Cooling Glove Study |
MAR 2007 |
17 pages |
| Authors:
David I. Rosen; John C. Magill; HARTMUT H. LEGNER; PHYSICAL SCIENCES INC ANDOVER MA
|
| Soldiers operating in the desert wearing body armor and other heavy clothing cannot adequately dissipate heat Both physical and mental fiincflons are impaired when body core temperature increases. Performance can be enhanced and health risks reduced with the aid of the body core cooling device being developed in this program. The development described here builds on successful demonstrations by Heller et al. at Stanford University, which showed that heat can ... |
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| Identification of Risk Factors for Exertional Heat Illness: A Brief Commentary on Genetic Testing |
Jan-2007 |
6 pages |
| Authors:
Sheila Muldoon; Rolf Bunger; Patricia Deuster; Nyamkhishing Sambuughin; UNIFORMED SERVICES UNIV OF THE HEALTH SCIENCES BETHESDA MD DEPT OF ANESTHESIOLOGY
|
| This commentary discusses known links between Exertional Heat Illness (EHI), Malignant Hyperthermia (MH), and other hereditary diseases of muscle. Genetic and functional testing is also evaluated as measures of fitness to return to duty/play. Data Sources: Reviews and research articles from Sports Medicine, Applied Physiology, and Anesthesiology. Data Extraction: Detailed comparisons of existing literature regarding clinical cases of EHI and MH and the potential utility of genetic testing, specifically the ... |
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| Heat Stroke and Cytokines |
2007 |
45 pages |
| Authors:
Lisa R. Leon; ARMY RESEARCH INST OF ENVIRONMENTAL MEDICINE NATICK MA THERMAL AND MOUNTAIN MEDICINE DIVISION
|
| Heat stroke is a life-threatening illness that affects all segments of society. The etiology of the long-term consequences of this syndrome remains poorly understood such that preventive/treatment strategies are needed to mitigate its debilitating effects. Cytokines are important modulators of the acute phase response to stress, infection and inflammation. Despite several studies implicating cytokines in heat stroke pathophysiology, few studies have examined the protective effect(s) of cytokine antagonism on the ... |
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| Thermoregulatory Function During the Marathon |
2007 |
5 pages |
| Authors:
Robert W. Kenefick; Samuel N. Cheuvront; Michael N. Sawka; ARMY RESEARCH INST OF ENVIRONMENTAL MEDICINE NATICK MA THERMAL AND MOUNTAIN MEDICINE DIVISION
|
| Marathon races are performed over a broad range of environmental conditions. Hyperthermia is a primary challenge for runners in temperature and warm weather, but hypothermia can be a concern during cool-wet or cold conditions. Body temperature during the marathon is a balance between metabolic heat production and exchange with the environment described by the heat balance equation. During exercise, core temperature is proportional to the metabolic rate and largely independent ... |
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| Exertional Heat Illness and Human Gene Expression |
2007 |
27 pages |
| Authors:
L.A. Sonna; M. N. Sawka; C. M. Lilly; ARMY RESEARCH INST OF ENVIRONMENTAL MEDICINE NATICK MA THERMAL AND MOUNTAIN MEDICINE DIVISION
|
| Microarray analysis of gene expression at the level of RNA has generated new insights into the relationship between cellular responses to acute heat shock in vitro, exercise, and exertional heat illness. Here we discuss the systemic physiology of exertional hyperthermia and exertional heat illness, and compare the results of several recent microarray studies performed in vitro on human cells subjected to heat shock and in vitro on samples obtained from ... |
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| Effect of Palm Cooling with Negative Pressure on Heat Balance During Exercise in a Hot, Dry Environment |
15 NOV 2006 |
78 pages |
| Authors:
Suzanne Schneider; Rob Robergs; Steve Verney; Fabiano Amorium; Paulette Yamada; NEW MEXICO UNIV ALBUQUERQUE
|
| Military personnel often must work in hot environments, increasing the risk of hyperthermia. Our purpose was to evaluate a new rapid thermal exchange device (RTX) in slowing the development of hyperthermia and associated symptoms to 3 other conditions [hand immersed in water bath (WB), water-perfused vest (VEST), and a no- cooling condition (NC)] in subjects exercising in a hot environment (42C, 30% rh) wearing summer fatigues, a backpack and body ... |
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| Optimized Hyperthermia Treatment of Prostate Cancer Using a Novel Intracavitary Ultrasound Array |
JAN 2006 |
189 pages |
| Authors:
Nadine Smith; PENNSYLVANIA STATE UNIV UNIVERSITY PARK
|
| Ultrasound induced hyperthermia is a useful adjuvant to radiation therapy in the treatment of prostate cancer. This requires specific ultrasound phased array design and appropriate thermometry method. Inhomogeneous, acoustical, three-dimensional (3D) prostate models and economical computational methods provide necessary tools to predict the appropriate shape of hyperthermia phased arrays for better focusing and steering. A 3D acoustical prostate model was created depending on photographical data from the Visible Human Project(trade ... |
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| The Thermoregulatory Consequences of Heat Stroke: Are Cytokines Involved |
2006 |
16 pages |
| Authors:
L. R. Leon; ARMY RESEARCH INST OF ENVIRONMENTAL MEDICINE NATICK MA THERMAL AND MOUNTAIN MEDICINE DIVISION
|
| The thermoregulatory changes induced by prolonged heat exposure consist of hyperthermia in response to direct heat exposure and a biphasic response consisting of hypothermia followed by "fever" which develops during long-term recovery. This review discusses the importance of these thermoregulatory responses for prediction of heat stroke morbidity and mortality and the potential role of endogenous cytokines in the regulation of these responses. Current data suggest that the magnitude and duration ... |
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| Image-Guided Surgery of Primary Breast Cancer Using Ultrasound Phased Arrays |
JUL 2005 |
59 pages |
| Authors:
Emad S. Ebbini; MINNESOTA UNIV MINNEAPOLIS
|
| Recent developments of piezocomposite transducer technology have led to the development of new generation of ultrasound phased arrays with imaging and therapeutic capabilities. These dual-mode arrays provide an ideal nonionizing noninvasive tool for the treatment of primary breast cancer. This project investigates the thresholds for tissue damage under a variety of exposure conditions to high-intensity focused ultrasound from dual-mode arrays. In addition, we investigate new imaging techniques for enhanced visualization ... |
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| A Low-Protein Diet Alters Rat Behavior and Neurotransmission in Normothermic and Hyperthermic Environments |
31 MAY 2005 |
7 pages |
| Authors:
Harris R. Lieberman; Sylva K. Yeghiayan; Timothy J. Maher; ARMY RESEARCH INST OF ENVIRONMENTAL MEDICINE NATICK MA MILITARY NUTRITION DIV
|
| Dietary protein contains amino acids used in the brain for synthesis of neurotransmitters. Although information on pre-and post-natal exposure to low-protein diets in rodents is available, little is known about the effects of such diets on adult humans. Therefore, the behavioral and neurochemical consequences of exposure to a brief (11 days), low-protein (4%) diet in animals exposed to normothermic and hyperthermic test conditions were examined. In separate groups of animals, ... |
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| Novel Magnetic Fluids for Breast Cancer Therapy |
APR 2005 |
13 pages |
| Authors:
Konstanty Mazuruk; ALABAMA UNIV IN HUNTSVILLE
|
| Magnetic particles with micron or sub-micron dimensions are now becoming highly attractive for many biomedical applications, such as targeted drug delivery, gene therapy, disease detection, biochemical sensing, genetic screening. Advances in these areas are largely due to the research progress in nano-technology and in magnetic fluid technology, in particular. The last one gave birth to the magnetic fluid hyperthermia (MFH) - an important tool for cancer treatment. Hyperthermia is a ... |
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| Cognitive Readiness in Network-Centric Operations |
01-Jan-2005 |
13 pages |
| Authors:
Gregory Belenky; Nancy J Wesensten; Thomas J Balkin; WALTER REED ARMY INST OF RESEARCH SILVER SPRING MD DIV OF PSYCHIATRY AND NEUROSCIENCE
|
| Network-centric warfare is the basis of doctrine and operations for the U.S. Army, Navy, and Air Force. Fundamental to network-centric warfare is the availability of accurate, detailed, real-time information at all levels of command and control. Network-centric operations and the associated self-synchronization put a premium on the performance of individual soldiers and small teams at all levels of command and control. A critical component of such performance is the ability ... |
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| Ranger Medic Evaluation for Field Use of a Core Temperature Monitoring Unit |
DEC 2004 |
70 pages |
| Authors:
William J. Tharion; Reed W. Hoyt; ARMY RESEARCH INST OF ENVIRONMENTAL MEDICINE NATICK MA BIOPHYSICS AND BIOMEDICAL MODELING DIV
|
| Management of heat injuries in military training and combat is a serious issue for military medical personnel. In addition to severe health consequences associated with heat stroke, it has been estimated that the cost of heat stroke injuries as a result of military training is approximately $10M/ year. The uses of new clinical tools to help diagnose and treat heat injuries are urgently needed. One device that may be useful ... |
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| Pilot Study Testing the Technical Feasibility and Toxicity of High Dose Rate Brachytherapy Combined with Hyperthermia to Treat Prostate Cancer Recurrences after External Beam Irradiation or Permanent Seed Implant Failure |
JUL 2004 |
25 pages |
| Authors:
Peter M. Corry; Alvaro Martinez; WILLIAM BEAUMONT HOSPITAL ROYAL OAK MI
|
| The principal objective of this research is the development of the combination of hyperthermia (HT) and high dose rate (HDR) brachytherapy as a therapy for locally advanced, recurrent prostate cancer after failure using front line external beam definitive radiation therapy (EBRT). We had previously developed a system for low dose rate systems (LDR), however technological advances in HDR systems make the application of LDR essentially obsolete. There are several fundamentally ... |
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| Targeting of Breast Tumors and Tumor Cells Using Inductive Magnetic Heating of Metallic Nanoparticles |
JUN 2004 |
7 pages |
| Authors:
Vincent M. Rotello; MASSACHUSETTS UNIV AMHERST
|
| Our research in the first year has focused on the creation of nanoparticles designed for hyperthermic tumor ablation via magnetic field heating, and the development of equipment for genetic magnetic field generation. In the area of nanoparticle fabrication, we have changed our focus from metallic nanoparticles to superparamagnetic analogs. This change was made to avoid th high frequencies and energy fluxes required for metallic system . In our synthetic studies, ... |
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| Novel Magnetic Fluids for Breast Cancer Therapy |
APR 2004 |
15 pages |
| Authors:
Konstanty Mazuruk; UNIVERSITY SPACE RESEARCH ASSOCIATION COLUMBIA MD
|
| The focus of this research effort is to investigate the synthesis strategies of magnetic nano-materials potentially exhibiting the temperature self-regulating properties that could be attractive for cancer therapeutic purposes. Ni-Pt alloy nano-particles are of specific interest in this study. The wet chemical approach was used (an inverse micelle method). Although micron-size particles can readily be produced with the required magnetic properties, a problem was encountered with the nano-material. Our understanding ... |
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| Practical Implementations of Real-Time Heart Rate Variability |
MAR 2004 |
37 pages |
| Authors:
Antonio Sastre; MIDWEST RESEARCH INST KANSAS CITY MO
|
| Heart rate variability (HRV) is a useful, non-invasive indicator of autonomic nervous system responsiveness that can be used to signal the need for life-saving interventions, but to date it has not been possible to use it in real-time (RT) . Because HRV reflects homeostasis in thermoregulation and blood pressure control, it provides a non-invasive "window" into these processes. The overall objectives of the present research program are to identify aspects ... |
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| Optimized Hyperthermia Treatment of Prostate Cancer Using a Novel Intracavitary Ultrasound Array |
JAN 2004 |
129 pages |
| Authors:
Nadine B. Smith; PENNSYLVANIA STATE UNIV UNIVERSITY PARK
|
| The eventual goal this research is to produce an ultrasound hyperthermia array which will uniformally heat the prostate to clinical temperatures for the treatment of prostate disease. This goal can be achieved by accounting for the physical differences between the prostate gland and surrounding tissue structures. It was therefore possible to design and construct as a transducer to produce uniform heating within the prostate while causing minimal damage to surrounding ... |
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| Heart Rate Variability as an Index of Physiological Strain in Hyperthermic and Dehydrated Rats |
2004 |
10 pages |
| Authors:
Candance B. Matthew; Amy M. Bastille; Richard R. Gonzalez; Ingrid V. Sils; Reed W. Hoyt; ARMY RESEARCH INST OF ENVIRONMENTAL MEDICINE NATICK MA THERMAL AND MOUNTAIN MEDICINE DIVISION
|
| Telemetry-equipped rats were subjected to hyperthermia (H, T sub c) = 41.5 deg C) with and without dehydration (D 9% loss of body weight) stresses. Time domain and spectral analysis of heart rate variability indicated that the dehydrated hyperthermic (DH) rats had increased sympathetic activity compared to H rats, and DH rats had decreased discriminated the more physiologically stressful of these states. These non-invasive measures of physiological strain discriminated the ... |
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| A Viable Neuroprotection Strategy Following Soman-induced Status Epilepticus |
DEC 2003 |
20 pages |
| Authors:
G. P. Ballough; M. G. Filbert; ARMY MEDICAL RESEARCH INST OF CHEMICAL DEFENSE ABERDEEN PROVING GROUND MD
|
| The present study examined the neuroprotective effectiveness of dantrolene in the prevention of soman-induced SRBD. (Dantrolene is FDA approved for the treatment of malignant hyperthermia.) The decision to consider this compound is based on its well-known mode of action in preventing the release of calcium from intracellular stores. In addition, we assessed possible synergistic overlap in the neuroprotective effectiveness of combined dantrolene and diazepam co-treatment. The combined neuroprotective effectiveness of ... |
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| Thermobrachytherapy for Recurrent Prostate Cancer |
JUL 2003 |
13 pages |
| Authors:
Peter M. Corry; WILLIAM BEAUMONT HOSPITAL ROYAL OAK MI
|
| The principal objective of this research is the development of the combination of hyperthermia (HT) and high dose rate (HDR) brachytherapy as a therapy for locally advanced, recurrent prostate cancer after failure using front line external beam definitive radiation therapy (EBRT). We had previously developed a system for low dose rate systems (LDR), however technological advances in HDR systems make the application of LDR essentially obsolete. There are several fundamentally ... |
|
| Microwave Confocal Detection and Thermal Therapy for Breast Cancer: Adaptive Phased Array System for In-Vitro Mapping/Targeting Telomerase Activity |
JUL 2003 |
27 pages |
| Authors:
Robert A. York; CALIFORNIA UNIV SANTA BARBARA
|
| Microwave hyperthermia has shown promise in the treatment of malignant breast tumors with minimal side effects due to the use of non-ionizing radiation. However the full potential has yet to be realized due to technological limitations. This project aimed to improve this technology in two areas. The first area of research is developing biocompatible vectors with high microwave absorbing and scattering materials. These would enhance in-vivo localization of target cells, ... |
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| Regulation of the Response to Radiotherapy and Hyperthermia in Prostate Cancer by the 26s Proteasome |
APR 2003 |
184 pages |
| Authors:
William H. McBride; CALIFORNIA UNIV LOS ANGELES
|
| The goal of the project was to evaluate the role of the proteasome in prostate cancer biology and response to heat and radiation therapy. We have shown considerable variation between prostate cancers in their functional proteasome activity. In all cases heat and radiation inhibit activity, and this is accompanied by changes in signal transduction pathways that are regulated through the proteasome. Most notably, NF-kappaB is suppressed by heat and by ... |
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| Thermobrachytherapy for Recurrent Prostate Cancer |
JUL 2002 |
21 pages |
| Authors:
Peter M. Corry; Alvaro Martinez; WILLIAM BEAUMONT HOSPITAL ROYAL OAK MI
|
| The principal objective of this research is the development of the combination of hyperthermia (HT) and high dose rate (HDR) brachytherapy as a therapy for locally advanced, recurrent prostate cancer after failure using front line external beam definitive radiation therapy (EBRT). We had previously developed a system for low dose rate systems (LDR), however technological advances in HDR systems make the application of LDR essentially obsolete. There are several fundamentally ... |
|
| Microwave Confocal Detection and Thermal Therapy for Breast Cancer: Adaptive Phased Array System for In-Vivo Mapping/Targeting Telomerase Activity |
JUL 2002 |
13 pages |
| Authors:
Robert A. York; CALIFORNIA UNIV SANTA BARBARA
|
| Microwave hyperthermia holds promise in the treatment of malignant breast tumors, with fewer side effects using non-ionizing radiation. However technical limitations continue to limit its use. This project seeks to overcome two such limitations. The first area of research is developing biocompatible vectors with high microwave absorbing and scattering materials, enhancing in- vivo localization of target cells, where the activity of specific markers is present. The second area of research ... |
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| Medical Surveillance Monthly Report (MSMR). Volume 8, Number 4, June 2002 |
Jun-2002 |
17 pages |
| Authors:
ARMED FORCES HEALTH SURVEILLANCE CENTER SILVER SPRING MD
|
| There are three critical determinants of heat associated injury risk: environmental conditions (temperature and humidity); intensity of physical activity; and individual characteristics (e.g., hydration status, physical fitness, underlying health). Heat associated injuries are a significant threat to military populations because of frequent occupational exposures to strenuous physical activities in hot and humid environments. The most serious heat-associated injury is heat stroke. Heat stroke is the state of extreme hyperthermia that ... |
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| The Preclinical Evaluation of Fever-Range, Whole Body Hyperthermia as a Adjuvant to Chemotherapy and Cytokine Immunotherapy for the Treatment of Breast Cancer |
JUN 2002 |
14 pages |
| Authors:
Michele T. Pritchard; HEALTH RESEARCH INC BUFFALO NY
|
| This grant was written to examine the effect of combining fever-range heat treatments (WBH) - with cytokine immunotherapy and chemotherapy in a mouse model of human breast cancer. Progress in year number three of this grant has revealed that the 4Tl mouse model is sensitive to WBH, resulting in a tumor growth delay and illustrative of similar effects of heat in other mouse models in the laboratory of the Pi's ... |
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| Operational and Thermophysiological Needs for Metabolic Heat Dissipation: Ways, Deviations, and Progress |
APR 2002 |
3 pages |
| Authors:
Hans-Joachim Knoefel; GERMAN AIR FORCE INST OF AVIATION MEDICINE MANCHING (GERMANY)
|
| The thermophysiological regulation of body temperature is partially or completely inhibited by protection suits especially when several qualities of protection are needed. The result of an insufficient thermophysiological response is heat stress with decreased mental and physical performance of the human being. To get an idea about the amount of heat stress different physiological values are measured: metabolic rate, heat frequency, mean skin and core temperature, sweat rate, psychological performance ... |
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| Physiological Response to Cold Exposure in Men: A Disabled Submarine Study |
2002 |
16 pages |
| Authors:
J. W. Castellani; C. O'Brien; D. A. Stulz; L.A. Blanchard; D. W. Degroot; M. E. Bovill; T. J. Francis; A. J. Young; ARMY RESEARCH INST OF ENVIRONMENTAL MEDICINE NATICK MA THERMAL AND MOUNTAIN MEDICINE DIVISION
|
| A disabled submarine (DISSUB) lacking power and/or environmental control will become cold, and the ambient air may become hypercapuic and hypoxic. This study examined if the combination of hypoxia, hypercapnia, and cold exposure would adversely affect thermoregulatory responses to acute cold exposure in survivors awaiting rescue. Seven male submariners (33 plus or minus 6 yrs) completed a series of cold-air tests (CAT) that consisted of 20-min at T(air) = 22 ... |
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| Optical Fiber Based Thermometry System for a Hyperthermia Laboratory |
25 OCT 2001 |
|
| Authors:
J. E. Chong; L. Leija; C. P. Pennisi; W. H. Fonseca; INSTITUTO POLITECHNICO NACIONAL MEXICOCITY ESQUELA SUPERIOR DE INGENIERIA QUIMICA E INDUSTRIAS EXTRACTIVAS
|
 | The development and construction of a thermometry system based on optical fiber sensors is presented. This system is used in a laboratory of experimental hyperthermia to characterize the distribution of temperature on a substitute material of biological tissue (phantom), when it is subjected to controlled electromagnetic or ultrasonic radiation. The experiments are carried out inside an anechoic chamber. The temperature sensors were developed based on plastic optical fibers that work ... |
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| International Thermal Physiology Symposium |
AUG 2001 |
197 pages |
| Authors:
Nigel Taylor; WOLLONGONG UNIV (AUSTRALIA)
|
| Partial Contents: THE EFFECT OF SLEEP DEPRIVATION UNDER BRIGHT LIGHT CONDITION ON THERMOREGURATOLY RESPONSES TO HYPERTHERMIA, ADENOSINE AND DOPAMINE AS NEUROMODULATORS IN HYPOXIC HYPOTHERMIA IN CONSCIOUS RATS, ROLE OF PREOPTIC AREA IN LPS-INDUCED BEHAVIORAL FEVER IN THE TOAD BUFO PARACNEMIS, TYMPAMC TEMPERATURE REACTION TO THE EXPOSURE TO ELECTHOMAGNETIC FIELDS EMITTED BY CELLULAR PHONE, CAN FINGER DEXTERITY BE MAINTAINED WITH LOW FINGER BLOOD FLOW?, MECHANISMS OF HYPOXIA-INDUCED HYPOTHERMIA, NIGHT FEEDING OF ... |
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| The Preclinical Evaluation of Fever-Range, Whole Body Hyperthermia as an Adjuvant to Chemotherapy and Cytokine Immunotherapy for the Treatment of Breast Cancer |
JUN 2001 |
10 pages |
| Authors:
Michele Pritchard; HEALTH RESEARCH INC BUFFALO NY
|
| This predoctoral grant was written to examine the effect of combining fever-range whole body hyperthermia with cytokine immunotherapy and chemotherapy in animal models of breast cancer. Progress in year number two has recently improved with the implementation of a new animal model that closely represents human breast cancer and will replace the less appropriate CT26 model (a colon cancer model) used in year number one. This represents the most significant ... |
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| Regulation of the Response to Radiotherapy and Hyperthermia in Prostate Cancer by the 26s Proteasome |
APR 2001 |
8 pages |
| Authors:
William H. McBride; CALIFORNIA UNIV LOS ANGELES
|
| The goal of this proposal was to quantify the extent to which human prostate cancer cells vary in their proteolytic proteasome associated activities, and to evaluate the role of the proteasome in the response of prostate cancer cells to hyperthermia and/or radiotherapy. Cell lines have been shown to vary considerably in their proteasome activity. Both irradiation and hyperthermia inhibit activity, but by different mechanisms. Further support has been obtained for ... |
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| The Preclinical Evaluation of Fever-Range, Whole Body Hyperthermia as anAdjuvant to Chemotherapy and Cytokine Immunotherapy for the Treatment of Breast Cancer |
JUN 2000 |
24 pages |
| Authors:
Michele Pritchard; HEALTH RESEARCH INC BUFFALO NY
|
| The work outlined in the original grant proposal was designed to develop new breast cancer treatments that combined a current breast cancer chemotherapy (doxorubicin and Doxil) and a cytokine-based immunotherapy (IL-l2 and IL-2) with fever-like whole body hyperthermia (WBH). We have found that the combination of WBH with Doxil does indeed result in a better anti-tumor effect in our SCID mouse human breast tumor xenograft ... |
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| Acute Oral Toxicity Evaluation of 2,6-Dibutyl-4-Nitrophenol in Male Sprague-Dawley Rats |
JUN 1999 |
19 pages |
| Authors:
K. L. MacMahon; W. H. Baker; W. K. Alexander; K. R. Still; G. B. Briggs; MANTECH-GEOCENTERS JOINT VENTURE DAYTON OH
|
| This study investigated the acute oral toxicity of 2,6-di-t-butyl-4- nitrophenol (DBNP) in male Sprague-Dawley rats. DBNP is formed in U.S. submarines when lube oil containing the antioxidant additive 2,6-di-t- butylphenol (DBP) is nitrated after passing through an electrostatic precipitator. DBNP has triggered human health concerns due to its adherence to painted surfaces causing a noticeable yellowing. Male Sprague-Dawley rats were dosed with DBNP in ... |
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| Nonlinear Acoustics in Underwater and Biomedical Applications: Array Performance Degradation and Time Reversal Invariance |
21 MAY 1999 |
151 pages |
| Authors:
Ibrahim M. Hallaj; UNIV OF WASHINGTON SEATTLE APPLIED PHYSICS LAB
|
| This dissertation describes a model for acoustic propagation in inhomogeneous fluid media and explores the focusing by arrays onto targets under various conditions. The work explores the use of arrays for acoustic and biomedical applications. Aspects of propagation and phasing that can lead to reduced focusing effectiveness are described. Among the most important debilitating effects studied here are medium absorption, medium nonlinearity, and imperfect initial phasing of the signals at ... |
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| Production of Interleukin-6 Over a Hyperthermic Range by Lipopolysaccharide Stimulated Neutrophils |
MAY 1999 |
49 pages |
| Authors:
Daniel J. Bessmer; WISCONSIN UNIV-MILWAUKEE
|
| Neutrophils are an essential cell of the immune system, responsible for phagocytosis of bacterial pathogens. However, their role in immunity is not limited to this action. The neutrophil response to and production of cytokines is paramount to successful immune responses. Interleukin-6 (IL-6) is an important cytokine produced by the neutrophil. This cytokine has pleotropic activity but of interest in this study is its ability to act as an endogenous pyrogen ... |
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| Non-Invasive Method of Inducing Hypothermia in Multiple Rats Simultaneously |
JAN 1999 |
20 pages |
| Authors:
Candace B. Matthew; WIliam D. Schrock; ARMY RESEARCH INST OF ENVIRONMENTAL MEDICINE NATICK MA
|
| Hypothermia has been and continues to be a problem faced by military personnel when operating in cold environments or when water immersion in moderate temperatures results in the loss of body heat that is not compensated for by heat production. Vascular leakage of large protein molecules and accompanying water or extravasation manifested in a loss of vascular volume is one of the pathophysiological findings resulting from rewarming following hypothermia. Recent ... |
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| Non-Invasive Method of Inducing Hypothermia in Multiple Rats Simultaneously |
JAN 1999 |
20 pages |
| Authors:
Candace B. Matthew; William D. Schrock; ARMY RESEARCH INST OF ENVIRONMENTAL MEDICINE NATICK MA
|
| Hypothermia has been and continues to be a problem faced by military personnel when operating in cold environments or when water immersion in moderate temperatures results in the loss of body heat that is not compensated for by heat production. Vascular leakage of large protein molecules and accompanying water or extravasation manifested in a loss of vascular volume is one of the pathophysiological findings resulting from rewarming following hypothermia. Recent ... |
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| Therapeutic Hypothermia Following Traumatic Spinal Injury: Morphologicaland Functional Correlates |
JAN 1999 |
57 pages |
| Authors:
Robert P. Yezierski; MIAMI UNIV FL SCHOOL OF MEDICINE
|
| The primary objective of experiments carried out during the second year focused on determining the behavioral significance of neuroprotective effects achieved by systemic hypothermia following moderate spinal cord injury. In these experiments moderate hypothermia was initiated 30 minutes post-injury for a period of four hours. Two days post-injury we initiated the behavioral assessment of locomotor function. In anticipation of future therapeutic applications of combined ... |
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| Development of an Inverse Technique to Estimate the Ultrasound Field During Chest Wall and Breast Hyperthermia |
SEP 1998 |
66 pages |
| Authors:
Charles L. Thomas; UTAH UNIV SALT LAKE CITY
|
| The goal of this research was to develop a clinical system for improved numerical modeling of ultrasound propagation through breast tissue and the post-mastectomy chest wall for use in patient treatment planning of hyperthermia cancer treatments. This has included the following: Development of an efficient numerical model that predicts the ultrasound behavior based on nodal tissue parameters. The tissue parameters are set using a combination ... |
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| Determination of Patients' Breast Tumor-Specific Immunity and Its Enhancement with In Vitro Stimulation and Gene Therapy |
MAR 1998 |
95 pages |
| Authors:
Elizabeth A. Repasky; HEALTH RESEARCH INC BUFFALO NY
|
| During the three years of our Army support, we have successfully completed the majority of the Specific Aims. We have succeeded in developing a model system for the growth of patients' primary breast tumors in the SCID mouse and this has appeared in print. We have correlated the growth pattern of these tumors in the SCID mouse model with clinical data concerning the diagnosis, treatment and prognosis of the patients. ... |
|
| Effects of Work Rate and Temperature on Work/Rest Cycles When Wearing the Chemical Defense Ensemble |
NOV 1997 |
163 pages |
| Authors:
Jack H. Wilmore; Heidi K. Byrne; Connie M. Mier; Janice L. Radcliff; TEXAS UNIV AT AUSTIN
|
| Phase I was comprised of three study periods, Phase IB and Phase IC, where subjects walked on a treadmill at ambient temperatures of 70 degrees Farenheit, 80 degrees Farenheit, 90 degrees Farenheit, and 100 degrees Farenheit in an environmental chamber at two different rates of work, tilde 300 watts (3.0 mph, 0% grade) and tilde 450 watts (3.5 mph, 3.5% grade) while wearing a USAF chemical Defense Ensemble. Subjects walked ... |
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| Role of Bc1-2 in Breast Cancer Progression |
SEP 1997 |
54 pages |
| Authors:
Hyeong-Reh Kim; WAYNE STATE UNIV DETROIT MI
|
| The anti-apoptotic gene bcl-2 is frequently overexpressed in many human tumors including invasive breast cancer. In vitro studies clearly demonstrate that the bcl-2 gene product prevents apoptosis following a variety of stimuli including radiation, hyperthermia, growth factor withdrawal and chemotherapeutic drugs. However, high levels of the bcl-2 expression have shown a positive correlation in clinicopathological studies, such as tumor grade and better response to hormonal treatment and chemotherapy. It is ... |
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| Use of Combination Thermal Therapy and Radiation in Breast-Conserving Treatment of Extensive Intraductal Breast Cancer |
JUL 1997 |
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| Authors:
Goran K. Svensson; BETH ISRAEL DEACONESS MEDICAL CENTER BOSTON MA
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| This research supports the development of a technique for breast cancer treatment using ultrasound hyperthermia (heat treatments produced by sound waves) in addition to standard treatment using radiation therapy. The rationale is that treatment of early stage breast cancer (Ductal Carcinoma in Situ, DCIS, and Extensive Intraductal Carcinoma, EIC) is based on the hypoxic (low oxygen) environment in parts of the tumor region that causes tumor cells to be less ... |
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| Real-Time Thermal Risk Assessment for the Dismounted Soldier |
MAR 97 |
41 pages |
| Authors:
Gary McWilliams; ARMY RESEARCH LAB WHITE SANDS MISSILE RANGE NM
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| This report discusses a real-time thermal risk assessment system for the dismounted soldier. This system has been jointly developed by the U.S. Army Research Laboratory and the U.S. Army Research Institute for Environmental Medicine. It is capable of providing work-to-rest ratios, water consumption requirements, and cold survival times that can be used to help prevent soldiers from becoming hyperthermic or hypothermic. The information can be generated over a region the ... |
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| State-to-State Reactive and Collisional Dynamics of Atmospheric Species |
NOV 96 |
16 pages |
| Authors:
David J. Nesbitt; COLORADO UNIV AT BOULDER
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| The AFOSR research efforts over the past three years have achieved the following goals. (1) We have now completed state to state scattering measurements for CH4, H2O and HF with rare gas (Ar, Ne and He) collision partners, based on direct infrared absorption in crossed molecular beams. (2) Hot atom state to state scattering of Cl with HCl has been studied using high resolution Dopplerimetric techniques to obtain both differential ... |
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Reports by Keyword(s)
HYPERTHERMIA
