| A FRET-Based Method for Probing the Conformational Behavior of an Intrinsically Disordered Repeat Domain from Bordetella pertussis Adenylate Cyclase |
22-Oct-2009 |
11 pages |
| Authors:
Geza R Szilvay; Mark A Blenner; Oren Shur; Donald M Cropek; Scott Banta; COLUMBIA UNIV NEW YORK DEPT OF CHEMICAL ENGINEERING
|
 | A better understanding of the conformational changes exhibited by intrinsically disordered proteins is necessary as we continue to unravel their myriad biological functions. In repeats in toxin (RTX) domains, calcium binding triggers the natively unstructured domain to adopt a ? roll structure. Here we present an in vitro Foerster resonance energy transfer (FRET)-based method for the investigation of the conformational behavior of an RTX domain from the Bordetella pertussis adenylate ... |
|
| Medical Equipment Used to Support Operations in Southwest Asia |
30-Sep-2009 |
62 pages |
| Authors:
INSPECTOR GENERAL DEPT OF DEFENSE ARLINGTON VA
|
| The objective of the audit was to determine whether controls were in place for acquiring mission-essential medical equipment and whether the recording and reporting of medical equipment was accurate and complete. We evaluated medical equipment accountability, inventory, maintenance, and procurement information at six military treatment facilities and five medical logistics activities in Afghanistan, Iraq, and Qatar. At those 11 locations, we analyzed and compared information to determine whether controls and ... |
|
| Viscoelastic Models for Nearly Incompressible Materials |
Sep-2009 |
62 pages |
| Authors:
Mike Scheidler; ARMY RESEARCH LAB ABERDEEN PROVING GROUND MD
|
| This report discusses linear and nonlinear constitutive models for the viscoelastic response of nearly incompressible solids undergoing moderate to large deformations and arbitrarily large rotations. For both the linear and nonlinear cases, the general theory is outlined first, then the Prony series approximation to the stress relaxation function is introduced, and this in turn is used to derive various incremental relations for the stress. These incremental relations can be easily ... |
|
| An Analysis of Bent Function Properties Using the Transeunt Triangle and the SRC-6 Reconfigurable Computer |
Sep-2009 |
140 pages |
| Authors:
Jennifer L Shafer; NAVAL POSTGRADUATE SCHOOL MONTEREY CA
|
| Linear attacks against cryptosystems can be defeated when combiner functions are composed of highly nonlinear Boolean functions. The highest nonlinearity Boolean functions, or bent functions, are not common--especially when they have many variables--bent functions are difficult to find. Understanding what properties are common to bent functions will help ease the search for them. Using the SRC-6 reconfigurable computer, functions can be generated or tested at a rate much higher than ... |
|
| Characteristics of the Binary Decision Diagrams of Boolean Bent Functions |
Sep-2009 |
174 pages |
| Authors:
Neil B Schafer; NAVAL POSTGRADUATE SCHOOL MONTEREY CA
|
| Boolean bent functions have desirable cryptographic properties in that they have maximum nonlinearity, which hardens a cryptographic function against linear cryptanalysis attacks. Furthermore, bent functions are extremely rare and difficult to find. Consequently, little is known generally about the characteristics of bent functions. One method of representing Boolean functions is with a reduced ordered binary decision diagram. Binary decision diagrams (BDD) represent functions in a tree structure that can be ... |
|
| The Homeland Security Enterprise: Where Do We Fit? |
Sep-2009 |
126 pages |
| Authors:
Kirk S Marlowe; NAVAL POSTGRADUATE SCHOOL MONTEREY CA DEPT OF NATIONAL SECURITY AFFAIRS
|
| Homeland security is a responsibility to be shared across the nation. Resource demands, differing cultures, and varying motivations result in frustration and confusion that conflict with the nation's need to collaborate and cooperate. As such, the homeland security enterprise appears to be imploding from turf battles, suspicion, poor communication, competitive funding, and mistrust, which cause stakeholders to wonder where they fit in this complex, interdependent environment. This study examines reports, ... |
|
| Planning the Optimal Transit for a Ship Through a Mapped Minefield |
Sep-2009 |
66 pages |
| Authors:
Pei-Chieh Li; NAVAL POSTGRADUATE SCHOOL MONTEREY CA DEPT OF OPERATIONS RESEARCH
|
| This thesis develops (a) a mission-planning tool for a Navy Mine Counter Measure (MCM) force to find a minimum-risk route for a surface ship through a mapped minefield, and (b) a heuristic to identify a sequence of mines whose clearance (removal and/or deactivation) leads to a rapid reduction of the risk of a minimum-risk path. All modeling concepts reflect the requirements of the Republic of China Navy's MCM operations. The ... |
|
| Finding Bent Functions Using Genetic Algorithms |
Sep-2009 |
199 pages |
| Authors:
Stuart W Schneider; NAVAL POSTGRADUATE SCHOOL MONTEREY CA DEPT OF ELECTRICAL AND COMPUTER ENGINEERING
|
| In this thesis, a generic genetic algorithm (GA) is presented that is implemented on a reconfigurable computer. Our GA is implemented such that many problems can be solved by simply adapting the problem to the GA. For example, part of this process involves the customization of the fitness function of the given problem to the GA. The size of the problem is limited by the capacity of a field programmable ... |
|
| Information Technology Sector Baseline Risk Assessment |
Aug-2009 |
115 pages |
| Authors:
DEPARTMENT OF HOMELAND SECURITY WASHINGTON DC
|
| The Information Technology (IT) Sector provides both products and services that support the efficient operation of today's global information-based society. These products and services are integral to the operations and services provided by other critical infrastructure and key resource (CIKR) sectors. Threats to the IT Sector are complex and varied. In addition to the risks presented by natural hazards? such as catastrophic weather or seismic events?the IT Sector also faces ... |
|
| The Role of BRCA1 Domains and Motifs in Tumor Suppression |
Aug-2009 |
|
| Authors:
Aneliya Velkova; H LEE MOFFITT CANCER CENTER AND RESEARCH INST TAMPA FL
|
 | The purpose of this research is to classify BRCA1 variants for which cancer association is not known (unclassified variants UCV). To approach this problem we hypothesized that poorly characterized but conserved domains in BRCA1 directly participate in its tumor suppression function. To test this hypothesis we choose a global approach analyzing several BRCA1 domains and point mutants in functions that have previously been attributed to BRCA1: long term survival after ... |
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| Hydrogeomorphic Approach to Assessing Wetland Functions: Guidelines for Developing Regional Guidelines: Chapter 8, Developing the Assessment Protocol |
Jul-2009 |
27 pages |
| Authors:
Chris V Noble; Lili Carpenter; ENGINEER RESEARCH AND DEVELOPMENT CENTER VICKSBURG MS ENVIRONMENTAL LAB
|
| This chapter of the Guidebook describes how to develop an Assessment Protocol, which is a chapter in all HGM Regional Guidebooks. It provides specific information necessary to develop an Assessment Protocol for a new regional guidebook using examples from existing regional guidebooks. The chapter describes how to collect data including red flag features, office and field equipment needs, plot layout, data collection procedures, and field data sheets used to collect ... |
|
| Inherently Governmental Functions and Department of Defense Operations: Background, Issues, and Options for Congress |
22-Jun-2009 |
|
| Authors:
Valerie B Grasso; Kate M Manuel; John R Luckey; LIBRARY OF CONGRESS WASHINGTON DC CONGRESSIONAL RESEARCH SERVICE
|
| An inherently governmental function is one that, as a matter of law and policy, must be performed by federal government employees and cannot be contracted out because it is intimately related to the public interest. Concerned that the existence of multiple and/or inconsistent definitions of inherently governmental functions might be partly responsible for the alleged contracting out of inherently governmental functions by the Department of Defense (DOD) and other agencies, ... |
|
| Inherently Governmental Functions and Department of Defense Operations: Background, Issues, and Options for Congress |
15-Jun-2009 |
|
| Authors:
Valerie B Grasso; Kate M Manuel; John R Luckey; LIBRARY OF CONGRESS WASHINGTON DC CONGRESSIONAL RESEARCH SERVICE
|
| An inherently governmental function is one that, as a matter of law and policy, must be performed by federal government employees and cannot be contracted out because it is intimately related to the public interest. Concerned that the existence of multiple and/or inconsistent definitions of inherently governmental functions might be partly responsible for the alleged contracting out of inherently governmental functions by the Department of Defense (DOD) and other agencies, ... |
|
| Review of Defense Contract Management Agency Support of the C-130J Aircraft Program |
12-Jun-2009 |
23 pages |
| Authors:
OFFICE OF INSPECTOR GENERAL ARLINGTON VA SPECIAL INSPECTOR GENERAL FOR IRAQ RECONSTRUCTION
|
| A September 8, 2008, allegation letter requested that the DoD Acting Inspector General review whether the Air Force or the C-130J prime contractor exerted inappropriate influence pertaining to the Defense Contract Management Agency (DCMA) contract administration function for the C-130J aircraft program. The allegation letter claimed that DCMA assisted the Air Force and the C-130J prime contractor in congressional lobbying efforts to reverse the December 2004 C-130J program termination decision ... |
|
| Identification of the Mechanisms Underlying Antiestrogen Resistance: Breast Cancer Research Partnership between FIU-UM Braman Family Breast Cancer Institute |
Jun-2009 |
13 pages |
| Authors:
Deodutta Roy; FLORIDA INTERNATIONAL UNIV MIAMI
|
| This research proposal has two primary objectives which are to (1) increase FIU investigators' research expertise and competitive ability to succeed as independent breast cancer researchers; and (2) to execute research with the promise of identifying molecular causes of breast tumor resistance to anti-estrogen therapy. This research is of significant merit because of its clinical relevance to breast cancer. Secondly, the research accomplishments through the FIU/BFBCI training program will lead ... |
|
| On Extending Temporal Models in Timed Influence Networks |
Jun-2009 |
39 pages |
| Authors:
Alexander H Levis; Abbas K Zaidi; P Papantoni-Kazakos; GEORGE MASON UNIV FAIRFAX VA SYSTEMS ARCHITECTURE LAB
|
| An extension to the formalism of Timed Influence Networks, including time-varying and cyclic influences is presented. The proposed time-varying influence functions allow modeling of influences whose strengths vary with time. A cyclic influence, on the other hand, provides a provision for a self-promoting set of influences. The two extensions will provide TIN models with the capability to depict PMESII (i.e., political, military, economic, social, infrastructure, and information) aspects of informal ... |
|
| Checkpoint Kinase-Dependent Regulation of DNA Repair and Genome Instability in Breast Cancer |
Jun-2009 |
29 pages |
| Authors:
Courtney A Lovejoy; VANDERBILT UNIV NASHVILLE TN
|
| The DNA damage response (DDR) functions as a tumorigenesis barrier. It is activated in precancerous lesions, potentially as a consequence of aberrant DNA replication. The genetic alterations that create this genomic instability are poorly defined. Using a functional genomic screen in human cells we identified seventy-four genes that when silenced by RNAi activate the DDR. Using a series of secondary assays we determined that many have DNA replication-associated genome maintenance ... |
|
| United States Air Force Unmanned Aircraft Systems Flight Plan 2009-2047 |
18-May-2009 |
77 pages |
| Authors:
DEPARTMENT OF THE AIR FORCE WASHINGTON DC
|
| Unmanned aircraft systems (UAS) and the effects they provide have emerged as one of the most in demand capabilities the USAF provides the Joint Force. The attributes of persistence, endurance, efficiency, and connectivity are proven force multipliers across the spectrum of global Joint military operations. This document presents a USAF Unmanned Aircraft Systems Flight Plan 2009 to 2047. it is an actionable plan, characterized by Doctrine, Organization, Training, Materiel, Leadership ... |
|
| Inhibition of the Protein Tyrosine Phosphatase, SHP-1, in Dendritic Cells to Enhance their Efficacy as Cell-Based Prostate Cancer Vaccines |
May-2009 |
18 pages |
| Authors:
Jonathan M Levitt; BAYLOR COLL OF MEDICINE HOUSTON TX
|
| Early preclinical and clinical trials suggest that dendritic cell (DC)-based tumor vaccines are both feasible and safe. However, to date clinical trials of DC-based vaccines have demonstrated only limited efficacy in causing tumorregression despite eliciting measurable systemic T cell responses against prostate cancer. In an effort to enhance the effectiveness of DC-based vaccines against prostate cancer, we have tested the hypothesis that the Src homology region 2 domain-containing phosphatase-1 (SHP-1), ... |
|
| Molecular Connections Between Arousal and Metabolic Disease: Orexin and Modafinil |
Apr-2009 |
19 pages |
| Authors:
Stephen C Benoit; CINCINNATI UNIV OH
|
| Metabolic diseases are known to be tightly linked to arousal-sleep cycles and impact cognitive function. Importantly, the armed forces represent a population at significant risk for increased stress and disrupted arousal-sleep cycles. Because the incidence of metabolic disease and obesity is increasing, even in these physically fit individuals, understanding the interactions between these systems is highly significant. Further, some anti-fatigue pharmacologies (e.g.,modafinil) are already used in military settings, though their ... |
|
| Objective Estimates of Westward Rossby Wave and Eddy Propagation from Sea Surface Height Analyses |
17-Mar-2009 |
19 pages |
| Authors:
C N Barron; A B Kara; G A Jacobs; NAVAL RESEARCH LAB STENNIS SPACE CENTER MS OCEANOGRAPHY DIV
|
| An objective method to estimate westward propagation of sea surface height (SSH) anomalies is introduced and compared to a subjective technique. Both approaches use time series extracted from global SSH analyses, prepared by optimal interpolation of altimeter data, as described in detail. The cost function used in the objective method calculates the mean along-slope standard deviation, where slope is the reciprocal of propagation speed and defines the angle of linear ... |
|
| Strategic Religious Engagement for Peacebuilding |
17-Mar-2009 |
34 pages |
| Authors:
Houck; Ira C III; GEORGE MASON UNIV FAIRFAX VA INSTITUTE FOR CONFLICT ANALYSIS AND RESOLUTION
|
| The U.S. Army Chaplaincy functions in its traditional roles as it exercises professional military religious leadership for the United States Army Family. At the same time the Chaplaincy is expanding its advisory capabilities to meet the needs of the combatant command in full spectrum operations, and is performing new tasks of conflict resolution through key political religious leader engagements, and religious and conflict analyses. Strategic Religious Engagement is respectful interaction ... |
|
| BRCA1 in Gene-specific Coordination of Transcription and DNA-Damage Response |
14-Mar-2009 |
9 pages |
| Authors:
Jianlong Sun; TEXAS UNIV HEALTH SCIENCE CENTER AT SAN ANTONIO
|
| BRCA1 is a tumor suppressor gene for hereditary breast and ovarian cancers. In collaborating with various binding partners, BRCA1 protein participates in multiple cellular functions. Characterization of these binding proteins of BRCA1 is therefore key to the complete understanding of BRCA1's role in tumor suppression. Cofactor of BRCA1 (COBRA1) is a novel BRCA1-interacting protein and shares several functional commonalities with BRCA1 in regulating expression of genes involved various types of ... |
|
| Organization of DoD Computer Network Defense, Exploitation, and Attack Forces |
12-Mar-2009 |
32 pages |
| Authors:
Kraig Hanson; ARMY WAR COLL CARLISLE BARRACKS PA
|
| The Department of Defense (DoD) faces many challenges in the world of computer networks and systems. Technical skills used to exploit adversary networks and systems for intelligence purposes can also be used to attack adversary networks and systems. In the likelihood that exploitation is much more common than attack, technicians performing exploitation will gain much experience in their work. Because of this, these same technicians should also perform attack functions, ... |
|
| Centralized Cooperative Control for Route Surveillance With Constant Communication |
Mar-2009 |
126 pages |
| Authors:
Joseph D Rosal; AIR FORCE INST OF TECH WRIGHT-PATTERSON AFB OH GRADUATE SCHOOL OF ENGINEERING AND MANAGEMENT
|
| The route surveillance (RS) mission is a new application of unmanned aircraft systems (UASs) to meet the reconnaissance and surveillance needs of combatant commanders. This mission intends to field a four-vehicle UAS that can provide surveillance of convoy routes. This research focuses on developing a solution strategy based on the application of optimal control and cooperative control theory. The RS controller uses the UAS team size to divide the route ... |
|
| Image Processing for Multiple-Target Tracking on a Graphics Processing Unit |
Mar-2009 |
79 pages |
| Authors:
Michael A Tanner; AIR FORCE INST OF TECH WRIGHT-PATTERSON AFB OH GRADUATE SCHOOL OF ENGINEERING AND MANAGEMENT
|
| Multiple-target tracking (MTT) systems have been implemented on many di?erent platforms, however these solutions are often expensive and have long development times. Such MTT implementations require custom hardware yet o?er very little flexibility with ever changing data sets and target tracking requirements. This research explores how to supplement and enhance MTT performance with an existing graphics processing unit (GPU) on a general computing platform. Typical computers are already equipped with ... |
|
| Microstructure-Sensitive Extreme Value Probabilities for High Cycle Fatigue of Ni-Base Superalloy IN100 (Preprint) |
Mar-2009 |
48 pages |
| Authors:
Craig P Przybyla; David L McDowell; AIR FORCE RESEARCH LAB WRIGHT-PATTERSON AFB OH MATERIALS AND MANUFACTURING DIRECTORATE
|
| To quantify the effects of interactions between various microstructure attributes on fatigue life in the high cycle fatigue (HCF) regime, we have proposed a new microstructure-sensitive extreme value statistical framework. This framework couples the extreme value distributions of certain fatigue indicator parameters (FIPs) or response functions to the correlated microstructure attributes that exist at the extreme value locations of these FIPs. We demonstrate the application of this statistical framework to ... |
|
| Role of PY Motif Containing Protein, WBP-2 in ER, PR Signaling and Breast Tumorigenesis |
Mar-2009 |
32 pages |
| Authors:
Zafar Nawaz; Sivapriya Ramamoorthy; MIAMI UNIV FL SCHOOL OF MEDICINE
|
| Our data demonstrates that WBP-2 is recruited onto the hormone responsive promoters in the presence of hormone and it specifically enhances the transactivation functions of PR and ER. Our data also demonstrates that WBP-2 contains an intrinsic activation domain and the cPPXY of WBP-2 is essential for its coactivation and intrinsic activation functions. Our preliminary data also demonstrates that the WBP-2 binding protein, YAP1 enhances PR and ER transactivation but ... |
|
| The President's Office of Science and Technology Policy: Issues for Congress |
06-Feb-2009 |
|
| Authors:
Deborah D Stine; LIBRARY OF CONGRESS WASHINGTON DC CONGRESSIONAL RESEARCH SERVICE
|
| Congress established the Office of Science and Technology Policy (OSTP) through the National Science and Technology Policy, Organization, and Priorities Act of 1976 (P.L. 94-282). The act states that The primary function of the OSTP Director is to provide, within the Executive Office of the President [EOP], advice on the scientific, engineering, and technological aspects of issues that require attention at the highest level of Government. Further, The Office shall ... |
|
| Laminin-5 gamma2 Chain in Breast Cancer Metastasis |
Feb-2009 |
10 pages |
| Authors:
Shanshan Liu; VANDERBILT UNIV NASHVILLE TN
|
| To metastasize, cancer cells have to break through the basement membrane. Ln-5 is one o f the basement membrane proteins, consisting of three chains a3,B3 and y2. Ln-5 y2 chain continas DIII domain, a functional EGFR ligand, which can be released by MMP processing. It has been suggested by our lab that DIII domain may facilitate cancer progression by preventing anoikis. However, both the increased and decreased expression levels of ... |
|
| Critical Thinking Training for Army Officers. Volume 2: A Model of Critical Thinking |
Feb-2009 |
106 pages |
| Authors:
V A Spiker; Sharon L Riedel; Susan C Fischer; ANACAPA SCIENCES INC SANTA BARBARA CA
|
| This report is the second of three volumes describing a multi-year research program to develop and evaluate web based training in critical thinking for Army officers. The first volume presents an overview of the research effort that developed and validated a theoretical model for the training, selected and validated eight high impact critical thinking skills for Army officers, and developed and evaluated the training course. This volume describes the results ... |
|
| Critical Thinking Training for Army Officers. Volume Three. Development and Assessment of a Web-Based Training Program |
Feb-2009 |
81 pages |
| Authors:
V A Spiker; Sharon L Riedel; Susan C Fischer; ARMY RESEARCH INST FOR THE BEHAVIORAL AND SOCIAL SCIENCES FORT LEAVENWORTH KS
|
| This is the third volume of a three-volume report describing a multi-year research program to develop and validate web based training in critical thinking for Army officers. The first volume presents an overview of the research effort that developed and validated a theoretical model for the training, selected and validated eight high impact critical thinking skills for Army officers, and developed and validated the training course. The second volume describes, ... |
|
| Glutamate Receptor Aptamers and ALS |
Jan-2009 |
30 pages |
| Authors:
Li Niu; STATE UNIV OF NEW YORK AT ALBANY RESEARCH FOUNDATION
|
| Excitotoxicity is one of the leading causes for amyotrophic lateral sclerosis (ALS). Our goal was to develop a novel class of powerful aptamer-based, anti-excitotoxic inhibitors against GluR2Qflip, a key AMPA receptor subunit that controls the calcium permeability and mediates excitotoxicity. An aptamer is a single-stranded nucleic acid that directly inhibits a protein's function by folding into a specific tertiary structure that dictates high-affinity binding to the target protein. To date, ... |
|
| Identification and Characterization of Genomic Amplifications in Ovarian Serous Carcinoma |
Jan-2009 |
148 pages |
| Authors:
Tian-Li Wang; JOHNS HOPKINS UNIV BALTIMORE MD SCHOOL OF MEDICINE
|
| The purpose of this proposed study is to apply genome-wide technologies to analyze ovarian cancer genome and transcriptome. We have accomplished all the proposed tasks as stated in the original grant. They include generating digital karyotyping libraries from ovarian carcinomas and perform transcirptome analysis in each amplicon. This effort leads us to identify at least two novel candidate oncogenes, Rsf1 and Notch3, which were up-regulated in both genomic DNA and ... |
|
| Neuroergonomics - Analyzing Brain Function to Enhance Human Performance in Complex Systems |
02-Dec-2008 |
38 pages |
| Authors:
Raja Parasuraman; GEORGE MASON UNIV FAIRFAX VA SYSTEMS ARCHITECTURE LAB
|
| Why Neuroergonomics? To design effective human-machine systems, we must (1) Understand mind in relation to work and technology -- ergonomics (2) Mind cannot be understood without studying the brain -- neuroscience (3) Hence study brain and mind in complex work domains -- Neuroergonomics. Neuroergonomics can provide for more effective and natural interaction between humans and technology. Two examples of Neuroergonomics: (1) Neuroimaging and adaptive automation -- Enhancing performance of operators ... |
|
| Using Sign Patterns to Distinguish Feared Clock Events |
01-Dec-2008 |
15 pages |
| Authors:
Matthias Suess; Ulrich Grunert; GERMAN AEROSPACE CENTER (DLR) OBERPFAFFENHOFEN (GERMANY)
|
| The first and second difference of clock measurements is investigated to detect and identify clock events. A hypothesis test of the difference functions is described which is calibrated by given Allan deviations of the observed clock differences. The impact of four defined clock events, namely time step, frequency step, drift step, and outlier on the first and second differences is calculated. The analysis outlines that the sign of these calculations ... |
|
| Self-Adaptive Dissemination of Critical Data in Dynamic Wireless Networks |
Dec-2008 |
9 pages |
| Authors:
Jose-Luis Sagripanti; David Dorsey; Bjorn J Carandang; Moshe Kam; Chris Gaughan; DREXEL UNIV PHILADELPHIA PA
|
| The distribution of data in large-scale dynamic wireless networks presents a difficult problem for network designers due to node mobility, unreliable links, and traffic congestion. In this work, we propose a framework for adaptive data dissemination protocols suitable for distributing data in large-scale dynamic networks without a central controlling entity. The framework consists of cooperating mobile agents and a reinforcement-learning component with value function approximation. A component for agent coordination ... |
|
| A Metadata Calculus for Securing Information Flows |
Dec-2008 |
8 pages |
| Authors:
Mudhakar Srivatsa; Dakshi Agrawal; Shane Balfe; IBM THOMAS J WATSON RESEARCH CENTER YORKTOWN HEIGHTS NY
|
| Traditional approaches to information sharing use a highly conservative approach to deduce the metadata for an output object x derived from input objects y(sub 1), y(sub 2), ... , y(sub n) [e.g.: maximum over the security labels of all input objects]. Such approaches does not account for functions that explicitly down- grade the value of an object. Consequently, the security labels in traditional approaches tend to monotonically increase as newer ... |
|
| Simulations of Simple Nanomachines in Carbon Nanotude Bundles Based on Chirality |
Dec-2008 |
8 pages |
| Authors:
D L Majure; R W Haskins; N J Lee; C R Welch; C F Cornwell; ENGINEER RESEARCH AND DEVELOPMENT CENTER VICKSBURG MS
|
| Single-walled carbon nanotubes (CNTs) have been studied extensively since their discovery and identification by Iijima in 1993. Their impressive mechanical, electrical, and thermal properties have created new fields of study, and the benefits of this research are just beginning to be realized. One potential use of CNTs is as a foundation for nanomachines. Another possible use, one that takes advantage of their mechanical properties, is the synthesis of high-strength, low-weight ... |
|
| Heat Acclimatisation and Active Body Cooling Strategies to Mitigate Heat Stress for Operations Involving Bullet Proof Vests |
Dec-2008 |
8 pages |
| Authors:
L Law; C L Lim; DEFENCE MEDICAL AND ENVIRONMENTAL RESEARCH INST (SINGAPORE)
|
| Heat acclimatization (HA) and personal body-cooling are effective methods of heat stress mitigation. HA involves conditioning the body to function under hot conditions by exposing the individual to an incremental level of heat stress daily over 10 to 14 days. Although HA improves thermoregulation during heat exposure, effective physical heat exchange between the body and environment must still take place. Operating with body armour may limit the benefits of HA ... |
|
| Macrolide Antibiotics Improve Phagocytic Capacity and Reduce Inflammation In Sulfur Mustard-Exposed Monocytes |
Dec-2008 |
9 pages |
| Authors:
Radharaman Ray; Prabhati Ray; Xiugong Gao; Yan Xiao; Keiko Ishida; WALTER REED ARMY INST OF RESEARCH SILVER SPRING MD
|
| Sulfur mustard (SM) inhalation causes apoptosis and death of airway epithelial cells as well as inflammation in the airway. Efficient clearance of the cell debris by alveolar macrophages (AMs) is necessitated to reduce the inflammation. Macrolide antibiotics have been reported to have anti-inflammatory properties by modulating the production of proinflammatory cytokines and mediators, and by improving macrophage functions. The present study investigated the effects of four FDA-approved macrolide antibiotics, namely ... |
|
| Customer Driven Uniform Manufacture (CDUM) Program. Customer Driven Uniform Management Apparel Research |
13-Nov-2008 |
158 pages |
| Authors:
Michael H O'Connell; PRODUCT DATA INTEGRATION TECHNOLOGIES INC LONG BEACH CA
|
| DLA (Defense Logistics Agency) and DSCP C&T (Defense Supply Center Philadelphia Clothing and Textiles) sponsored ARN's and CDUM's primary goals, which are to reduce total supply chain costs and inventory levels while minimizing retail shortages. The foundation for the achievement of these goals is the existence of web accessible databases that provide total supply chain asset visibility to all functions that manufacture products, make decisions, distribute products, and consume apparel ... |
|
| Enhanced Detection of Orthogonal Radar Waveforms Using Time-Frequency and Bi-Frequency Signal Processing Techniques |
01-Sep-2008 |
135 pages |
| Authors:
Patrick B Kistner; David M Crescitelli; NAVAL POSTGRADUATE SCHOOL MONTEREY CA
|
| This thesis investigates the periodic autocorrelation function (PACF) and periodic ambiguity function (PAF) for orthogonal continuous waveform (CW) modulations used in netted low probability of intercept (LPI) radar. Three orthogonal polyphase sequences and one frequency coding sequence are examined and their PACF and PAF characteristics are quantified. The Wigner-Ville distribution (WVD) and quadrature mirror filter bank (QMFB) time-frequency signal processing techniques and the cyclostationary bi-frequency technique (often used in non-cooperative ... |
|
| High-Order Non-Reflecting Boundary Conditions for the Linearized Euler Equations |
01-Sep-2008 |
202 pages |
| Authors:
John R Dea; NAVAL POSTGRADUATE SCHOOL MONTEREY CA
|
| We wish to solve fluid flow problems in only a portion of a large or infinite domain. By restricting our area of interest, we effectively create a boundary where none exists physically dividing our computational domain from the rest of the physical domain. The challenge we must overcome, then, is defining this boundary in such a way that it behaves computationally as if there were no physical boundary. Such a ... |
|
| Human Mammary Epithelial Cell Transformation by Rho GTPase through a Novel Mechanism |
Aug-2008 |
46 pages |
| Authors:
Vimia Band; NEBRASKA UNIV MEDICAL CENTER OMAHA
|
| Rho family small GTPases serve as molecular switches in the regulation of diverse cellular functions. Importantly, Rho overexpression is frequently seen in many carcinomas. However, published studies have almost invariably utilized immortal or tumorigenic cell lines to study Rho GTPase functions and there are no studies on the potential of Rho small GTPase to overcome senescence checkpoints and induce preneoplastic transformation of human epithelial cells (hMECs). We demonstrate here, that ... |
|
| Accountability for Defense Security Service Assets With Personally Identifiable Information |
24-Jul-2008 |
67 pages |
| Authors:
Paul J Granetto; Antwan Jackson; David A Palmer; Andrew R MacAttram; Robert P Goldberg; Rhonda L Ragsdale; Patricia A Papas; Kimberley A Caprio; Robert F II; Prinzbach; Marlene Cruz-Freire; Bridgette A Seebacher; INSPECTOR GENERAL DEPT OF DEFENSE ARLINGTON VA
|
| The management at the Defense Security Service (DSS) and personnel concerned with property accountability should read this report because it discusses accountability for assets that contain personally identifiable information (PII) and the requirements for reporting unauthorized disclosure of PII. DSS provides the Secretary of Defense, DoD Components, and Defense contractors security support services. In February 2005, DSS transferred responsibility for the personnel security investigation function to the Office of Personnel ... |
|
| Targeting Androgen Receptor Function by MicroRNA in Prostate Cancer |
Jul-2008 |
7 pages |
| Authors:
Girish C Shukla; CLEVELAND CLINIC FOUNDATION OH
|
| Prostate cancer is the most commonly diagnosed and second most deadly cancer in North American men and the blockade of androgen action through the AR has been the cornerstone of systemic therapy of prostate cancer. However, the effectiveness of this therapy is rather transient which inevitably fails and tumor growth resumes despite androgen blockade. The failure of AR receptor antagonists results in higher levels of AR protein which promotes the ... |
|
| Subwavelength Imaging |
12-Jun-2008 |
19 pages |
| Authors:
Kevin J Webb; Huikan Liu; Alon Ludwig; S Schivanand; PURDUE UNIV LAFAYETTE IN SCHOOL OF ELECTRICAL AND COMPUTER ENGINEERING
|
| The imaging properties of a uniaxial anisotropic slab lens, where the dielectric tensor components are of opposite sign, are studied as a function of the structure parameters. While hypothetical parameters yield various levels of performance, a design principle to achieve good sub-wavelength resolution is suggested. The anisotropy can be implemented with a metal-insulator stack. The influence of material and thickness on the subwavelength imaging performance of a negative dielectric constant ... |
|
| Critical Thinking Training for Army Officers Volume One: Overview of Research Program |
Jun-2008 |
35 pages |
| Authors:
V A Spiker; Sharon L Riedel; Susan C Fischer; ANACAPA SCIENCES INC SANTA BARBARA CA
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| This report is the first of three volumes describing a multi-year research program to develop and validate web based training in critical thinking for Army officers. This first volume presents an overview of the research efforts that developed and validated a theoretical model for the training, selected and validated eight high impact critical thinking skills for Army officers, and developed and evaluated the training course. The report documents the systematic ... |
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| The Path to a Culturally Relevant National Security Strategy |
22-May-2008 |
47 pages |
| Authors:
John Frappler; ARMY COMMAND AND GENERAL STAFF COLL FORT LEAVENWORTH KS SCHOOL OF ADVANCED MILITARY STUDIES
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| This monograph will argue that understanding and addressing the nature of the threat's identity is paramount to the United States' ability to win the GWOT. In an attempt to remain ahead of its enemies in the prosecution of the GWOT, the United States has proceeded with an extensive review of its National Security Strategy and an historic transformation of its Government, thereby improving its ability to protect the US' interests ... |
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