| Nanofluidic Pre-Concentration Devices for Enhancing the Detection Sensitivity and Selectivity of Biomarkers for Human Performance Monitoring |
01 Dec 2012 |
42 pages |
| Authors:
Chia-Fu Chou; ACADEMIA SINICA NANKANG TAIPEI (TAIWAN) INST OF PHYSICS
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 | Mass transport has generally been recognized as a major limiting factor in the sensitivity and performance of miniaturized sensor platforms. To overcome this limitation, a new approach, termed molecular dam, has been developed to enhance mass transport for protein enrichment in nanofluidic channels by nanoscale electrodeless dielectrophoresis under physiological buffer conditions. The researchers demonstrated protein enrichment factor to be greater than 105-fold in 20 seconds, which is orders of magnitude ... |
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| Acoustic Metamaterials Through a Microfluidic, Bottom-up Approach: Toward Highly Attenuating, Negative Effective Density Materials |
Oct 2012 |
9 pages |
| Authors:
Ashod Aradian; Oliver Mondain-Monval; S Raffy; T Brunet; J Leng; B Mascaro; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE TALENCE (FRANCE) LAB DE CHIMIE DU SOLIDE
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| Our initial idea was to build metamaterials with specific properties such as large attenuation capacities in a targeted field of frequencies. If much work has been up to now performed using centimetre-sized handmade mechanical resonators adapted to audible frequencies [1-3], fewer attempts have been made on smaller micro-resonators, in the 100 m range, i.e. for ultrasonic frequencies. Following this path, we recently proposed two different microfluidic approaches to get such ... |
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| Nanofluidic Pre-Concentration Devices for Enhancing the Detection Sensitivity and Selectivity of Biomarkers for Human Performance Monitoring |
09 Aug 2012 |
5 pages |
| Authors:
Nathan S Swami; Hsueh-Chia Chang; Chia-Fu Chou; VIRGINIA UNIV CHARLOTTESVILLE
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| Towards enhancing the detection sensitivity of biomarkers for real-time human performance monitoring in bio-fluid media the researchers have developed nano-device platforms for pre-concentration, separation and enhancement of binding kinetics of target species to sensing elements. They will apply these methods to key biomarkers in year 2. |
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| Development Of Nanoenergetic Micro-fluidic Jet Injectors |
Jan 2012 |
20 pages |
| Authors:
Clay S Staley; Christopher J Morris; Luke J Currano; ARMY RESEARCH LAB ADELPHI MD SENSORS AND ELECTRON DEVICES DIRECTORATE
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| We present the fabrication, assembly, and packaging of first generation nanoenergetic fluidic jet generators. The generators consist of an energetic material chamber, elastic piston, vaccine reservoir, and convergent nozzle cap all tightly bonded in a self-contained device using micro-electromechanical system (MEMS) processing techniques. Maximum deformation lengths of the polydimethylsiloxane (PDMS) membranes are characterized as a function of PDMS diameter, PDMS thickness, energetic material composition, and energetic material mass using high-speed ... |
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| Electromagnetically Tunable Fluids |
29 Nov 2011 |
27 pages |
| Authors:
G H Huff; M A Bevan; Z Ounaies; J Boyd; D Lagoudas; TEXAS ENGINEERING EXPERIMENT STATION COLLEGE STATION
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| The overarching goal of this project was to exploit the transport properties at colloidal and microfluidic dimensions to controllably alter the high-frequency electromagnetic material properties at the macro level. This was to achieve multifunctionality and reconconfigurability at device-level (antenna) scales through tunability provided by a combination of structural colloidal components and functional microfluidic components; the microfluidic system was used to both reversibly control physical properties through fluidic transport and provide ... |
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| Ready-to-use Aptamer Biosensors for DNT and RDX |
29 Sep 2011 |
15 pages |
| Authors:
Hyonsok T Soh; Y Xiao; CALIFORNIA UNIV SANTA BARBARA
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| Aptamers are nucleic acid-based reagents that bind to target molecules with high affinity and specificity. However, methods for generating aptamers from random combinatorial libraries (e.g., SELEX) are often labor-intensive and time-consuming. To address this problem, we have recently demonstrated the microfluidic SELEX (M-SELEX) technology that can accelerate aptamer isolation by enabling highly stringent selection conditions through the use of very small amounts of target molecules (X. Lou et a/, PNAS ... |
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| Tunable Microfluidic Microlasers |
Sep 2011 |
21 pages |
| Authors:
Francesco Simoni; UNIVERSITA POLITECNICA DELLE MARCHE ANCONA (ITALY)
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| According to the lines of the proposed activity we have completed the following tasks: a) recording and characterization of holographic gratings in different polymeric materials and their integration in optofluidic circuits; b) investigation of liquid crystals alignment under microfluidic conditions; c) design and test of laser geometries and demonstration of laser emission. The objective of getting laser tuning by exploiting the orientational properties of liquid crystal in microfluidic condition has ... |
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| Integrated Semiconductor-based Diagnostics System for Multiplexed Genomic Amplification and Electrochemical Detection of Biothreat Agents |
Jan-2009 |
85 pages |
| Authors:
Kia Peyvan; David L Danley; COMBIMATRIX CORP MUKILTEO WA
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| This contract effort focused on the development of an automated, cartridge-based genotyping system that integrates a multiplex polymerase chain reaction (PCR) assay with a semiconductor microarray that uses electrochemical detection to identify biothreat agents. The DX-100 Genotyping Cartridge System has three subcomponents: a disposable cartridge, the cartridge processing instrument, and a personal computer. The alpha prototype is compact and solid state (no optics) and has a simple three step operation: ... |
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| Fluidic Flexible Matrix Composites for Autonomous Structural Tailoring |
08-Sep-2008 |
20 pages |
| Authors:
K W Wang; Charles E Bakis; Christopher D Rahn; PENNSYLVANIA STATE UNIV UNIVERSITY PARK
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| This project develops Fluidic Flexible Matrix Composites (F2MC) and structures that have controllable and reversible stiffness change. F2MC tubes are fiber wound and filled with fluid. If the fluid flows freely in and out of the tube then the stiffness is relatively low. Blocking the fluid flow by closing a valve results in high stiffness. In this investigation, we develop an accurate analytical model to predict and optimize F2MC tube ... |
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| Design and Fabrication of Integration Biological Systems |
18-Apr-2008 |
|
| Authors:
Drew Endy; MASSACHUSETTS INST OF TECH CAMBRIDGE
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 | This grant provided a $43,832 supplement to the DARPA award, Design and Fabrication of Integration Biological Systems, to support the design, fabrication, and use of polydimethylsiloxane (PDMS) microfluidic chips and manifold control equipment. |
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| Biocompatible and Biomimetic Self Assembly of Functional Nanostructures |
17 JAN 2008 |
22 pages |
| Authors:
Jeffrey Brinker; NEW MEXICO UNIV ALBUQUERQUE DEPT OF CHEMICAL AND NUCLEAR ENGINEERING
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| Immobilization of individual cells and collections of cells in well defined reproducible nano-to-microscale structures that allow structural and functional manipulation and interrogation is important for developing new classes of biotic/abiotic materials for establishing the relationship between genotype and phenotype and for elucidating responses to disease injury/stress or therapy - primary goals of biomedical research Although there has been considerable recent progress in investigating the response of cells to chemical or ... |
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| The Fluidic Metaphor: A View into the Nature and Future of War |
Jan-2008 |
44 pages |
| Authors:
Geoffrey F Weiss; MARINE CORPS COMBAT DEVELOPMENT COMMAND QUANTICO VA
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| War is a complex and chaotic continuum; but it is not indecipherable. Applying to war the same holistic approach and language that science has provided for the chaotic behavior of fluids can yield surprising insight into war's nature and by extension, its future. This paper introduces a comprehensive metaphorical theory for war based on the properties of fluids, a fluidic metaphor. This theory is intended to clarify the nature of ... |
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| Development of Magnetic Nanomaterials and Devices for Biological Applications |
30 OCT 2007 |
41 pages |
| Authors:
Charles J. O'Connor; Josef Hormes; Nicolas Bazan; NEW ORLEANS UNIV LA ADVANCED MATERIALS RESEARCH INST
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| This report describes a research project in the area of bio-magnetic interfacing concepts aimed at the development of magnetic nanomaterials and devices for biological applications. Novel bio-compatible ferrofluids of functionalized magnetic nanoparticles suitable for bioconjugation of antibodies or other active biomolecules are developed, prepared, and tested for use in biomedical research, and various biological and clinical diagnostic applications. |
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| Electro-Magnetic Actuated Valve for MEMS Fuel Metering System |
01-Sep-2007 |
45 pages |
| Authors:
Albert P Pisano; CALIFORNIA UNIV BERKELEY
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| The goal of this research project is to develop a fuel injection system which delivers the desired ratio of air/fuel mixture to small scale internal combustion engines. Small scale engines require precise fuel control, but the fuel delivery system must be small and low-power. Our research is focused on the development of a planar fuel valve with high fuel delivery rates. The planar nature allows for successful system integration with ... |
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| Radar Absorbing Colloidal Solutions (RACS) |
AUG 2007 |
16 pages |
| Authors:
Conrad Stoldt; Michael H. Stowell; Zoya Popovic; Albert P. Pisano; David C. Walther; COLORADO UNIV AT BOULDER DEPT OF MECHANICAL ENGINEERING
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| Lastly, studies were directed toward the development and modeling of colloid containing microfluidics for the active modulation of microwave absorption. A method for the self-pumping of immiscible fluids was developed and a numerical model was formulated to estimate liquid flow rates in the microchannels as a function of different parameters including device dimensions and fluid properties. Initial work also focused on the development of non-lossy injection molded microfluidic platforms fabricated ... |
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| Rapid, Femtomolar Bioassays in Complex Matrices ComBining Microfluidics and Magnetoelectronics |
22 MAR 2007 |
32 pages |
| Authors:
S. P. Mulvaney; C. L. Cole; M. D. Kniller; M. Malito; C. R. Tamanaha; J. C. Rife; M. W. Stanton; L. J. Whitman; NAVAL RESEARCH LAB WASHINGTON DC
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| A significant challenge for all biosensor systems is to achieve high assay sensitivity and specificity while minimizing sample preparation requirements, operational complexity, and sample-to-answer time. We have achieved multiplexed, unamplified, femtomolar detection of both DNA and proteins in complex matrices "including whole blood, serum, plasma, and milk" in minutes using as few as two reagents by labeling conventional assay schemes with micrometerscale magnetic beads, and applying fluidic force discrimination "FFD". ... |
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| Powering the Integrated Microsystem (BRIEFING CHARTS) |
07-Mar-2007 |
18 pages |
| Authors:
John D Evans; DEFENSE ADVANCED RESEARCH PROJECTS AGENCY ARLINGTON VA MICROSYSTEMS TECHNOLOGY OFFICE
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| A 10,000-Pen Nanoplotter with Integrated Ink Delivery System |
03 MAR 2007 |
26 pages |
| Authors:
Chad A. Mirkin; NORTHWESTERN UNIV EVANSTON IL DEPT OF CHEMISTRY
|
| This report summarizes major scientific and technological accomplishments during the three years of this grant. It includes an extensive list of articles published in peer reviewed journals and participation in scientific meetings, workshops, and lectures. Finally, patent disclosures, transitions, and awards earned by the participating investigators are listed. Over the three-year project period significant progress has been made in both areas. The Liu group took the lead in developing new ... |
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| Challenges and Opportunities for Biophotonic Devices in the Liquid State and the Solid State |
JUL 2006 |
4 pages |
| Authors:
A. J. Steckl; J. A. Hagen; Z. Yu; R. A. Jones; W. Li; D. Han; D. Y. Kim; H. Spaeth; J. G. Grote; F. K. Hopkins; CINCINNATI UNIV OH NANOELECTRONICS LAB
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| In this paper we discuss the unique challenges and opportunities present in using biomaterials in photonics applications. We describe biophotonic materials and devices fabricated and operated in the solid state (fluorescent nanometer thin films, light emitting diodes) and in the liquid state (electrofluidic fluorescent biosensor, microfluidic switches). |
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| Fabrication and Characterization of a Micro Turbine/Bearing Rig |
2006 |
6 pages |
| Authors:
Chuang-Chia Lin; Reza Ghodssi; Arturo A. Ayon; Dye-Zone Chen; Stuart Jacobson; Kenneth Breuer; Alan H. Epstein; Martin A. Schmidt; MASSACHUSETTS INST OF TECH CAMBRIDGE MICROSYSTEMS TECHNOLOGY LABS
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| This paper reports on a process to build, package, and instrument a 5-level wafer-bonded micro-machined turbine/bearing rig. The process flow involves the use of 5 wafers, 16 masks, and 9 deep silicon etching steps. It also utilizes aligned wafer bonding, double-sided deep reactive ion etching (DRIE), and Laser-Assisted-Etching (LAE). The paper also presents experimental results on flow characteristics of the hydrostatic thrust bearings and the preliminary rotational performance of the ... |
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| Vascular Materials for Human Heat Management and Wound Healing |
31 DEC 2005 |
8 pages |
| Authors:
Abraham Stroock; CORNELL UNIV ITHACA NY
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| The key to our experimental approach to the creation of Vascular Materials is the development of material syntheses and methods of micro-fabrication that allow us to embed micro-fluidic structure directly within hydrogels. For the operation and characterization of systems (Artificial Leaves, Wound Dressings, and Tissue Scaffolds) based on Vascular Materials, we have developed experiments to control and monitor fluxes of heat and mass in an automated fashion. In parallel, we ... |
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| Biofluidic Intelligent Processors for Preparative Manipulations of Biological Warfare Agents at the Attomole Level |
NOV 2005 |
172 pages |
| Authors:
Paul W. Bohn; Johnathan V. Sweedler; Mark A. Shannon; ILLINOIS UNIV AT URBANA BECKMAN INST
|
| A new type of biofluidic transport system, the Biofluidic Intelligent Processor (BIP), was developed which specifically used biological compounds to adaptively control the transport of microfluids. The multicompartment, multimembrane BIP system was designed, fabricated and tested. The BIP had characteristic linear dimensions of nanometers and volumes as small as tens of attoliters, and was specifically designed to manipulate nano-amounts of species. Electrokinetic and other standard microfluidic flows were exploited to ... |
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| SONICFLIP: An Integrated Platform for Biofluid Monitoring |
NOV 2005 |
50 pages |
| Authors:
Amit Lal; CORNELL UNIV ITHACA NY
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| The SonicFlip project created technologies that enable microfluidic integration at a wristwatch scale with Complimentary Metal Oxide Semiconductor, CMOS, electronics compatible voltages and currents. The architecture included a CMOS chip driving an array of piezoelectric actuators. By driving the actuators at different phases, we achieved pumping and mixing. Since each pixel was under electronic control, programmable forces were achieved inside microfluidic channels. A fabrication method was developed to create pillars ... |
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| Electronic Sensing for Microfluidic Devices |
08 OCT 2005 |
12 pages |
| Authors:
Lydia L. Sohn; David Beebe; Daniel Notterman; CALIFORNIA UNIV BERKELEY SPONSORED PROJECTS OFFICE
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| Rapid characterization of biological specimens is increasingly important in research and clinical applications. While current optical and chemical detection techniques can effectively analyze biological systems, a number of disadvantages restrict their versatility. As examples: most samples require advanced processing such as PCR amplification or chemical treatment, and photobleaching often limits the optical probing of fluorophore-tagged samples. Purely electronic techniques, such as those we propose here, provide solutions to many such ... |
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| Microfluidic Cell Volume Biosensor for High Throughput Drug Screening |
13 JUL 2005 |
6 pages |
| Authors:
Daniel A. Ateya; Frederick Sachs; Susan Z. Hua; STATE UNIV OF NEW YORK AT BUFFALO DEPT OF MECHANICAL AND AEROSPACE ENGINEERING
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| The maintenance of cell volume is critical to health. Cell volume change reflects many biological and physicological processes. We have developed a lab-chip to measure cell volume change in real-time with high sensitivity and resolution, and applicable to both adherent and suspended cell populations. The volume change was detected by measuring the impedance of extra-cellular solution within a microfluidic chamber containing the cells. Using microfabrication to make precise chamber dimensions, ... |
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| Microfluidic Integration on Detector Array for Absorption and Fluorescence Micro-Spectrometers |
01 JUN 2005 |
8 pages |
| Authors:
Mark L. Adam; Markus Enzelberger; Stephen Quake; Axel Scherer; CALIFORNIA INST OF TECH PASADENA DEPT OF ELECTRICAL ENGINEERING
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| We describe a new approach for miniaturizing spectrometers by combining replica molded elastomeric micro-channels with filtered silicon detector arrays. Elastomers are excellent transparent materials, which provide hermetic seals to silicon dioxide and allow sensitive absorption and fluorescent spectroscopy in the visible and near-UV wavelength range. When integrated on dense detector arrays, such spectroscopy can be conducted on picoliter sample volumes. Elastomeric fluidic systems also permit easy integration of spectroscopic measurements ... |
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| An Advanced Platform for Biomolecular Detection and Analysis Systems |
FEB 2005 |
149 pages |
| Authors:
David J. Beebe; WISCONSIN UNIV-MADISON
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| A comprehensive new approach to the rapid and flexible construction of microfluidic-based systems for biological and chemical (BC) agent detection has been demonstrated. The foundation of the approach is a new manufacturing process called MicroFluidic Tectonics that combines responsive hydrogel materials with novel liquid phase Microfluidic construction methods. The approach addresses several critical issues relevant to BC agent defense - simple device fabrication, just-in-time manufacturing, integration of all system functions ... |
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| Transitioning Submersible Chemical Analyzer Technologies for Sustained, Autonomous Observations from Profiling Moorings, Gliders and other AUVs |
01-Jan-2005 |
9 pages |
| Authors:
Alfred K Hanson; Percy L Donaghay; Casey Moore; Richard Arrieta; SUBCHEM SYSTEMS INC JAMESTOWN RI
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| The long term goal is to transition existing prototype autonomous profiling nutrient analyzers into commercial products that can be readily deployed on autonomous profiling moorings, coastal gliders and propeller driven unmanned underwater vehicles and used for sustained, autonomous ocean observations of chemical distributions and variability. A series of issues have been identified that need to be addressed. These issues are; (1) a more compact size, (2) reduced reagent and power ... |
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| Development of a Micro- and Nano-Fabrication Facility |
08 DEC 2004 |
6 pages |
| Authors:
Alexander Couzis; Lane Gilchrist; Charles Maldarelli; David Rumschitzki; Maribel Vazquez; CITY COLL OF THE CITY UNIV OF NEW YORK
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| The purpose of this project was to develop the first multiuser micro and nanofabrication facility at The City College of New York (CCNY). Four pieces of equipment were acquired under this award: (i) Spin Coating System from Laurell Technologies; (ii) Ozone Stripper from Samco; (iii) Reactive Ion Etcher from Samco; and (iv) Evaporator/Sputtering system from Denton Vacuum. In addition, our school provided additional matching funds that enabled this research group ... |
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| Liquid-Propellant Rocket Engine Injector Dynamics and Combustion Processes at Supercritical Conditions |
NOV 2004 |
251 pages |
| Authors:
Vigor Yang; PENNSYLVANIA STATE UNIV UNIVERSITY PARK DEPT OF MECHANICAL ENGINEERING
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| The present AFOSR project focuses on the theoretical modeling and numerical simulation of liquid-propellant rocket engine injector flow and combustion dynamics. Emphasis is placed on cryogenic propellants in both shear and swirl co-axial injectors at supercritical conditions. The formulation is based on the full conservation equations in three dimensions, and accommodates variable properties and finite-rate chemical kinetics. Full account is taken of various high-pressure phenomena such as thermodynamic non- idealities ... |
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| Adaptive Lens Inspired by Bio-Visual Systems |
06 OCT 2004 |
18 pages |
| Authors:
Yu-Hwa Lo; CALIFORNIA UNIV SAN DIEGO LA JOLLA DEPT OF ELECTRICAL AND COMPUTER ENGINEERING
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| During the DARPA BOSS I program, the UCSD team has made substantial progress in the following areas: (a) We have identified and demonstrated the merits of PDMS elastomer for lens membranes. The PDMS-based fluidic lens process has been proven to be simple, controllable, and scalable to form lenses from 10 urn to several centimeters in diameter. (b) We have demonstrated fluidic tunable lenses with an exceedingly wide tuning range and ... |
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| The BioFlip Microcytometer |
10 SEP 2004 |
44 pages |
| Authors:
Aravind Padmanabhan; HONEYWELL INC PLYMOUTH MN
|
| This four-year program successfully demonstrated a point-of-care (POC) integrated scattering and fluorescence flow cytometer capable of counting and classifying white blood cells from a whole-blood sample input. The instrument development and overall system testing tasks on this project were performed by Honeywell and the disposable cartridge development was led by Micronics. The revolutionary miniaturization of a cytometer was enabled by the core technology strengths of Honeywell and Micronics. As part ... |
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| Designing Lithographically Patterned Phospholipid Bilayer Arrays for Next- Generation Biosensors and Immunoassays |
14 JUN 2004 |
9 pages |
| Authors:
Paul S. Cremer; TEXAS A AND M UNIV COLLEGE STATION DEPT OF CHEMISTRY
|
| We have met approximately 90% of the goals outlined in our original grant application. Fifteen papers were published acknowledging ARO funding. The work accomplished involves the exploitation of temperature, concentration, pH, and ionic strength gradients on-chip for use in heterogeneous immunoassays for ligand-receptor binding at biomembrane surfaces. The platforms we have built allow for high throughput measurements, while requiring only microliters of solution in order to obtain binding information. The ... |
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| Monolithic Integration of Microfluidics and Optoelectronics for Biological Analysis |
15 APR 2004 |
3 pages |
| Authors:
Axel Scherer; Stephen Quake; CALIFORNIA INST OF TECH PASADENA
|
| We have integrated microfluidic structures with optoelectronic lasers in the same device. Very sensitive and ultra-small laser sensors could be connected to fluidic systems by using microfluidic multiplexing technology and replication molded microfluidic chips. The basis of our sensor is a two- dimensional photonic crystal laser with an unusual cavity geometry that permits the introduction of analyte into the highest optical field region. This photonic crystal laser sensor can measure ... |
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| Optical Supramolecules for Chemical and Physical Sensing |
02 APR 2004 |
13 pages |
| Authors:
Daniel G. Nocera; MASSACHUSETTS INST OF TECH CAMBRIDGE DEPT OF CHEMISTRY
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| This proposal seeks to bring to the AFOSR a strategy to use bio- inspired concepts of recognition and signal transduction to unite the areas of optical chemosensing and nanoscience to address diverse chemical and physical sensing needs of the United States Air Force. Luminescent molecule, supramolecule or materials have been synthesized for targeted sensing application. An intrinsic component of the program has been to define fundamental parameters that control the ... |
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| The Design and Control of Smart Structures |
JAN 2004 |
23 pages |
| Authors:
Roger W. Brockett; P. S. Krishnaprasad; John Baillieul; HARVARD UNIV CAMBRIDGE MA
|
| This is the final report of the Boston University, Harvard University and University of Maryland MURI on Design and Control of Smart Structures. The report contains a summary of results obtained from the inception of the program in May 1997 until its conclusion in August, 2003. Over this period the researchers involved produced new and useful results in the areas of micromechanical devices (fabricated and used at ARL), micro fluidics, ... |
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| Lattice Boltzmann Simulation of Particle Laden Flows in Microfluidic Systems |
DEC 2003 |
35 pages |
| Authors:
David S. Clague; Todd Weisgraber; Elizabeth Wheeler; LAWRENCE LIVERMORE NATIONAL LAB CA
|
| The goal of this effort was to develop dynamic simulation tools to study and characterize particulate transport in Microfluidic devices. This includes the effects of external fields and near-field particle-particle, particle-surface interactions. The unique aspects of this effort are that we focused on the particles in suspension and rigorously accounted for all of the interactions that they experienced in solution. In contrast, other numerical methods within the program, finite element ... |
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| Nanoporous Membrane Technologies for Pathogen Collection, Separation, and Detection |
19 NOV 2003 |
22 pages |
| Authors:
Sang W. Lee; Hao Shang; Gil U. Lee; Matthew T. Griffin; Jack Fulton; PURDUE UNIV LAFAYETTE IN SCHOOL OF CHEMICAL ENGINEERING
|
| Partial contents: Nanoporous Membranes, Membrane Chemistries, Characterization of Membrane Chemistries,Protein Fouling, Collector,Gas and Liquid Permeabilities, Membrane Permeabilities in the Presence of Water, Operation Characteristics, 3 Day Laboratory Trial, Collector Prototype, Performance of the Prototype,Separator - Solute Permeabilities, Protein Permeability, Collector & Separator Fluidics, Detection, Self-assembled Monolayers, Ovalbumin Binding, Nanoporous Membrane Separation Methodologies, and Acknowledgements. |
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| Raptor: A Portable Biosensor Upgraded for Reliability and Sensitivity |
01-Jul-2003 |
9 pages |
| Authors:
George P Anderson; NAVAL RESEARCH LAB WASHINGTON DC CENTER FOR BIOMOLECULAR SCIENCE AND ENGINEERING
|
| The RAPTOR is a commercial, portable (5.6 kg) automated fiber optic biosensor able to detect up to four biological threat agents simultaneously. It performs rapid (5 to 13 minute) fluorescent sandwich immunoassays on the surface of four short polystyrene optical probes. The optical waveguide can be reused up to forty times, or until a positive result is obtained, reducing the logistical burden for field operations. The newest version of the ... |
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| Electronic Sensors for Microfluidics |
JUN 2003 |
54 pages |
| Authors:
Lydia L. Sohn; PRINCETON UNIV NJ DEPT OF PHYSICS
|
| The goal of this ARO/DARPA funded project is to develop a fully integrated microfluidic device that would be capable of electronically detecting specific bacterial pathogens in whole blood, and other fluids such as sputum and urine. The integrated device consists of two sensors: a microscale Coulter counter that sizeds and then fractionates blood samples based on particulate size; and an on-chip high frequency spectrometer that interrogates the dielectric response of ... |
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| Computational Fluid Dynamics Models of Molecularly Imprinted Materials in Microfluidic Channels |
21 MAY 2003 |
5 pages |
| Authors:
Cindy K. Webber; M. J. Roberts; NAVAL AIR WARFARE CENTER CHINA LAKE CA POLYMER SCIENCE AND ENGINEERING BRANCH
|
| Current research will lead to rapid-prototyping of chemical sensors that utilize microfabricated molecularly imprinted (MI) materials. CFD/CAD software may be used to model flow and chemical binding properties of Ml materials in microfluidic channels. Use of this type of software expedites results when changes in properties are made. The surface concentration of bound analyze on a monolithic molecularly imprinted polymer (MIP) within microfluidic channels can be modeled using its experimental ... |
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| Biochemical IC Chips Fabricated by Hybrid Microstereolithography |
APR 2003 |
13 pages |
| Authors:
Koji Ikuta; Shoji Maruo; Tadahiro Hasegawa; Takao Adachi; Atsushi Takahashi; NAGOYA UNIV (JAPAN) DEPT OF MICROSYSTEM ENGINEERING
|
| The world's first microstereolithography named 'IH process' was developed by Ikuta et al. in 1992. Several types of micro stereo lithography including Hybrid-IH process, Super-IH process and Two-photon IH process, have been also developed. Three-dimensional (3D) resolution has reached to 140 nm in the two-photon IR process. The super-IH process and the two-photon process enable direct writing of movable micromechanisms without assembling process or sacrificial layer technique. The hybrid-IR process ... |
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| Engineering Solutions for Robust and Efficient Microfluidic Biomolecular Systems: Mixing, Fabrication, Diagnostics, Modeling, Antifouling and Functional Materials |
SEP 2002 |
20 pages |
| Authors:
Jeff Moore; Hassan Aref; Ron Adrian; Deborah Leckband; David J. Beebe; ILLINOIS UNIV AT URBANA DEPT OF MECHANICAL AND INDUSTRIAL ENGINEERING
|
| We have developed several key components for microfluidic bioanalysis systems, including the following: 1. Microfluidic component fabrication and prototyping 2. Development of microflow diagnostic tools 3. Micron-scale fluid flow mixing enhancement 4. Flow modeling of micromixing processes 5. Biomolecular fluid stream handling and anti-fouling techniques 6. Spatial and temporal zeta potential control 7. Integration of functional materials in microfluidic systems. |
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| Phase 2 SBIR Final Report: An Ultra-Sensitive Optical Biosensor for Flood Safety |
23 AUG 2002 |
248 pages |
| Authors:
SATCON TECHNOLOGY CORP CAMBRIDGE MA
|
| The further development of a unique interferometric based optical biosensor platform for the rapid unlabelled detection and identification of foodborne pathogens was carried out under Phase II SBIR contract DAAD16-01-C- 0001 entitled: An Ultra-Sensitive Optical Biosensor for Food Safety. The potential in combining optical methods with biomolecular recognition techniques is the high signal gain derived from photonic amplification and thus high sensitivity, specificity, and rapid response time. |
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| Novel Asymmetric III-V/II-VI Hybrid Heterostructures for High-Power Mid- Infrared Laser |
01 JUN 2002 |
55 pages |
| Authors:
Yury Yakovlev; RUSSIAN ACADEMY OF SCIENCES SAINT PETERSBURG IOFFE PHYSICAL- TECHNICAL INST
|
| This report results from a contract tasking Ioffe Institute as follows: The main objectives of the proposal include technological, structural, theoretical and electro-optical studies of the novel asymmetric III-VIII-VI hybrid heterostructures and fabrication of these structures as mid-infrared lasers. We are proposing a new physical approach consisting of combining III-V and II-VI compounds in the one hybrid asymmetric laser structure based on Al(Ga) SbAs/InAs/Cd(Mg)Se which will lead to large conduction ... |
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| Relaxor Ferroelectric Single Crystal Based Hybrid Actuator for Underwater Acoustic Noise Generation |
MAY 2002 |
1460 pages |
| Authors:
Nesbitt W. Hagood Iv; MASSACHUSETTS INST OF TECH CAMBRIDGE DEPT OF AERONAUTICS AND ASTRONAUTICS
|
| This report details the development of a microfabricated pump for underwater acoustic noise generation. The goal of MicroHydraulic Transducer (MHT) technology is to provide high power density servohydraulic actilation systems that can be used in a variety of applications. Hydroacoustic actuation is a good application for such technology. The goal here is to develop an acoustic noise source capable of radiating approximately 0.25- 0.5W of acoustic power under water at ... |
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| Materials Research Society Symposium Proceedings. Volume 723. Molecularly Imprinted Materials - Sensors and Other Devices. Symposia Held in San Francisco, California on April 2-5, 2002 |
05 APR 2002 |
|
| Authors:
Kenneth J. Shea; Mingdi Yan; M. J. Roberts; Paul S. Cremer; Richard M. Crooks; MATERIALS RESEARCH SOCIETY WARRENDALE PA
|
| This symposium proceeding contains papers presented at Symposium M, "Molecularly Imprinted Materials," and Symposium O, "Chemical and Biological Sensors - Materials and Devices," held April 2-5 at the 2002 MRS Spring Meeting in San Francisco, California. Symposium M was the first of its kind at a Materials Research Society Meeting. The symposium consisted of 17 talks and 15 posters and brought together a number of scientists in the field to ... |
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| Flume Computer-Aided Design (CAD): Integrated CAD for Microflume Components and Systems |
APR 2002 |
184 pages |
| Authors:
John R. Gilbert; Manish Deshpande; MICROCOSM TECHNOLOGIES INC RALEIGH NC
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| This effort was aimed at developing a computer-aided design (CAD) system to allow start-to-finish design of a broad class of micromechanical fluid systems. The NetFlow program, previously completed under DARPA funding, developed the capability to model the diverse transport phenomena that are present in micromechanical systems. FlumeCAD extends this toolkit to include simulation of active components as well as providing the capability to extract behavior models. Tools for simulating the ... |
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| Nonlinear Adaptive Control of AC Electric Drives |
31 MAR 2002 |
11 pages |
| Authors:
Gilead Tadmor; Aleksandar Stankovic; NORTHEASTERN UNIV BOSTON MA
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| The use of energy dynamics/dissipative design is one unifying theme for the various projects carried under this grant, exploring the scope of quadratically dissipative design, design based on shaping Hamiltonian dynamics and design for systems with non-quadratic energy structures. Specific projects involved the permanent magnet synchronous, switch reluctance, induction and DC motors, power electronics devices, including a three phase synchronous rectifiers, the series resonant converter, voltage source inverters, and power ... |
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| Inorganic Self-Assembly Routes to Three-Dimensional Memories and Logical Mesostructures |
05 MAR 2002 |
12 pages |
| Authors:
Thomas E. Mallouk; Michael J. Natan; Theresa S. Mayer; Thomas N. Jackson; Z. J. Zhange; PENNSYLVANIA STATE UNIV UNIVERSITY PARK DEPT OF CHEMISTRY
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| This work sought to develop chemical components and self-assembly techniques for molecular electronic circuits. Specific objectives were to use membrane replication methods to make segmented metal and semiconductor rod colloids, and to develop techniques for assembling them into cross-point arrays for functional circuits. The major accomplishments were demonstration of nanowire synthesis down to diameters of 12 nm with aspect ratios exceeding 100, development of an electrofluidic technique for aligning and ... |
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Reports by Keyword(s)
FLUIDICS
