| Epigenetic Regulation of Chermokine Expression in Prostate Cancer |
Dec-2008 |
17 pages |
| Authors:
Michael R Shurin; PITTSBURGH UNIV PA
|
 | Specific active immunotherapy is based on the principle that malignant cells contain immunogenic sites against which an antitumor immune response can be induced. Dendritic cells (DC) that acquire antigens from tumor cells are able to induce and regulate specific antitumor immunity. However, it is still unclear why the circulating DC do not induce efficient antitumor immunity in cancer patients. While successful immunotherapy requires a functional immune system, a defect in ... |
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| Stem Cells in Prostate |
MAR 2006 |
22 pages |
| Authors:
Gail P. Risbridger; MONASH UNIV CLAYTON (AUSTRALIA)
|
| This project aims to identify adult prostate stem cells using tissue recombination technology. To date we have successfully directed the differentiation of mouse and human embryonic stem (ES) cells as outlined in the original statement of work. We have shown pathologically and histologically that the resultant tissue recombinants are highly characteristic of mouse and human prostate. We have refined the technology so that we reliably get prostate like tissues 0 ... |
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| Genetic and Epigenetic Silencing of the AS3 Proliferative rrest Gene in Prostate Cancer |
APR 2005 |
17 pages |
| Authors:
Peter Geck; TUFTS UNIV BOSTON MA
|
| Prostate cancer is the second leading cause of death among American men. The present proposal extends the molecular progress in prostate cancer into clinical practice by developing innovative markers. The current androgen ablation treatment is initially therapeutic, but most patients relapse. A novel androgen substitution approach uses androgens to promote terminal differentiation and arrest cancer. Markers of differentiation, however, are not known in the prostate. We discovered a novel gene, ... |
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| Smad-Mediated Signaling During Prostate Growth and Development |
OCT 2004 |
10 pages |
| Authors:
Charles Shuler; UNIVERSITY OF SOUTHERN CALIFORNIA LOS ANGELES
|
| SPECIFIC AIM 1: To define the developmental and temporo-spatial expression of Smad genes during embryonic prostate development (i) in vivo and (ii) in neonatal mouse prostate organ culture. SPECIFIC AIM 2: To determine the molecular mechanisms of TGF-beta pathway restricted Smad2 and Smad3 in regulating prostate ductal branching morphogenesis and cytodifferentiation in serumless organ culture. SPECIFIC AIM 3: To define the biological function of the feedback inhibitory Smad7 and Smad6 ... |
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| Genetic and Epigenetic Silencing of the AS3 Proliferative Arrest Gene in Prostate Cancer |
APR 2004 |
18 pages |
| Authors:
Peter Geck; TUFTS UNIV BOSTON MA
|
| Prostate cancer is the second leading cause of death among American men. The present proposal extends the molecular progress in prostate cancer into clinical practice by developing innovative markers. The current androgen ablation treatment is initially therapeutic, but most patients relapse. A novel androgen substitution approach uses androgens to promote terminal differentiation and arrest cancer. Markers of differentiation, however, are not known in the prostate. We discovered a novel gene, ... |
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| Genetic and Epigenetic Mechanisms Underlying Acute and Delayed Neurodegenerative Consequences of Stress and Anticholinesterase Exposure |
AUG 2003 |
86 pages |
| Authors:
Hermona Soreq; HEBREW UNIV JERUSALEM (ISRAEL)
|
| The effect of stress and exposure to anti-cholinesterases on the cholinergic system were tested in vitro and in vivo. Rapid muscle fatigue was identified and electrophysiologically characterized in mice with elevated levels of AChE-S, the synaptic variant of acetylcholinesterase (AChE). Anxiety responses were observed in mice that over-expressed the stress-associated variant, AChE-R. The binding partner of AChE-R in mouse neurons was identified as a component of the protein kinase-C signaling ... |
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| Development and Characterization of Transgenic Mice with Mammary Gland Specific Expression of the Tumor Suppressor |
JUL 2002 |
77 pages |
| Authors:
Muling Mao; Bruce D. Cuevas; M D ANDERSON CANCER CENTER HOUSTON TX
|
| The MMAC1/PTEN/TEP1 phosphatase tumor suppressor gene contributes to the initiation and progression of breast cancer as indicated by being the cause of the Cowden's breast cancer predisposition syndrome, being mutated in a subset of breast cancers, particularly advanced breast cancer and by being decreased in breast cancers by epigenetic mechanism. Recent evidence suggests that decreased PTEN levels or function rather than complete deletion may contribute to cancer development Our preliminary ... |
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| 3D Reconstruction and Morphological Quantization of a Human Embryo Heart for the Validation of a Virtual Model |
25 OCT 2001 |
|
| Authors:
J. -l. Dillenseger; J. -m. Schleich; UNIVERSITE DE RENNES (FRANCE) LAB TRAITEMENT DU SIGNAL ET DE L'IMAGE
|
 | This paper will present the methodology used for the reconstruction of a human 13 Weeks of Age (WOA) embryo heart. This reconstructed heart is visualized and some quantitative measurements are performed in order to allow the validation of a virtual computer generated heart model. |
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| Genetics of PTEN in Cowden Syndrome and Sporadic Breast Cancer |
OCT 2001 |
66 pages |
| Authors:
Charis Eng; OHIO STATE UNIV RESEARCH FOUNDATION COLUMBUS
|
| Germline mutations in PTEN on 10q23.3 cause 80% of classic Cowden syndrome (CS) and SO of Bannayan-Riley-Ruvalcaba syndrome (CS) as well as up to 20% of Proteus syndrome and up to 50 of unclassified Proteus-like syndromes. The major thrust of this grant was to identify and characterize PTEN's involvement in families and individuals with one ore more CS component tumors, of which prominently is breast cancer. During the funding period, ... |
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| RAR Beta Methylation and Loss of RAR Beta Expression in Breast Cancer |
SEP 2001 |
19 pages |
| Authors:
Nicoletta Sacchi; JOHNS HOPKINS UNIV BALTIMORE MD SCHOOLOF MEDICINE
|
| The search of chemopreventive strategies for breast cancer is imperative. It is vital to identify critical early events that can increase the risk that a normal epithelial mammary cell may be transformed into a breast cancer cell. Exposure to estrogen, already, recognized as a predisposing event for breast cancer, formed the rationale for preventive trials based on an antiestrogen compound (tamoxifen). This proposal explores the mechanism of another likely predisposing ... |
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| Functional Characterization of the Murine Homologue of PLAB, A Novel TGF-B Member, in Placental and Mammary Tissues |
JUN 2001 |
14 pages |
| Authors:
Guy S. Eakin; M D ANDERSON CANCER CENTER HOUSTON TX
|
| The goal of this proposal was to generate and analyze mice mutant for the mPlab gene. The gene was successfully cloned and sequenced. The targeting vector for production of null embryonic stem cells was constructed. Embryonic Stem (ES) cells containing the conditionally null allele of mPlab were created. While testing these ES cells for correct homologous recombination events, we discovered that the mPlab gene had already been knocked out by ... |
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| Cloning of an ets-Related Transcription Factor Involved in a Novel Epigenetic Mechanism of Mammary Carcinogenesis |
MAY 2001 |
|
| Authors:
Helmut Zarbl; FRED HUTCHINSON CANCER RESEARCH CENTERSEATTLE WA
|
| Our previous studies in pubescent female rats suggested that nitrosomethylurea (NMU) mediated epigenetic effects on DNA conformation within the Ha-ras promoter contributes to mammary carcinogenesis. The DNA region affected by NMU includes a transcriptional element identical to Ha-ras response element (HRE) found in human Ha-ras promoter. To identify the trans-acting factors that bind to the HRE sequence in mammary cells, we employed sequence specific DNA affinity chromatography and amino acid ... |
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| Genetic and Epigenetic Mechanisms Underlying Acute and Delayed Neurodegenerative Consequences of Stress and Anticholinesterase Exposure |
AUG 2000 |
174 pages |
| Authors:
Hermona Soreq; HEBREW UNIV JERUSALEM (ISRAEL)
|
| To characterize neuropathological consequences of excess acetyicholinesterase (AChE), we employed transgenic mice developed under previous US Army support. These mice demonstrated association between such excess and adverse responses (in brain and intestine) to pyridostigmine and diisopropylfluorophosphonate. The stress-associated "readthrough" AChE-R variant was seen also in progenitor blood cells, suggesting its use as a surrogate marker for anti-AChE responses. Moreover, AChE-R accumulates in the brain ... |
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| Cloning of an ets-Related Transcription Factor Involved in a Novel Epigenetic Mechanism of Mammary Carcinogenesis |
MAY 2000 |
|
| Authors:
Helmut Zarbl; FRED HUTCHINSON CANCER RESEARCH CENTERSEATTLE WA
|
| Our previous studies in pubescent female rats suggested that nitrosomethylurea (NMU) mediated epigenetic effects on DNA conformation within the Ha-ras promoter contributes to mammary carcinogenesis. The DNA region affected by NMU includes a transcriptional element identical to Ha-ras response element (HRE) found in human Ha-ras promoter. To identify the trans-acting factors that bind to the HRE sequence in mammary cells, we employed sequence specific DNA affinity chromatography and amino acid ... |
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| Isolation and Characterization of Spicule Matrix Protein |
31 AUG 1998 |
4 pages |
| Authors:
William J. Lennarz; STATE UNIV OF NEW YORK AT STONY BROOK
|
| Ongoing work in our laboratory has shown that suBMP, a bone morphogenetic protein-i family member, is the homolog of the Drosophila embryonic patterning gene Tolloid. Resequencing the 3' end of the suBMP-1 cDNAs has revealed an extended open reading frame with high homology to human and murine tolloid homologs. Recent studies in the laboratories of Darwin Prockop, Daniel Greenspan, and Effrat Kessler have demonstrated that ... |
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| Studies on Human Breast Cancer and Transforming Growth Factor-Beta Application for a Career Development Award |
OCT 1996 |
|
| Authors:
Bradley A. Arrick; DARTMOUTH COLL HANOVER NH
|
| The primary focus of the research is the expression of TGF-Beta by breast cancer cells. For established tumors, overexpression of TGF-Beta may result in increased in vivo tumor growth and metastatic spread. The first objective involves the analysis of resected breast cancer specimens, with the goal of confirming our prior work correlating clinical outcome with TGF-Beta expression levels in tumors. There are as yet no definitive data or conclusions from ... |
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| Radiofrequency Radiation and Teratogenesis: A Comprehensive Review of the Literature Pertinent to Air Force Operations |
JUN 96 |
121 pages |
| Authors:
Louis N. Heynick; Peter Polson; ARMSTRONG LAB BROOKS AFB TX OCCUPATIONAL AND ENVIRONMENTAL HEALTH DIRECTORATE
|
| This report on analyses of various research investigations that sought teratogenetic effects of exposure to radiofrequency radiation (RFR) is one of a planned series of various topics dealing with actual or possible biological effects of RFR and their potential consequences regarding human health. In this report, critiques are presented of the research papers (in English) on the topic RFR-induced teratogenesis, selected predominantly from the peer-reviewed literature. with few exceptions. presentations ... |
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| Dose (and Time Dependent) Blockade of Pregnancy in Sprague-Dawley Rats Administered Ammonium Dinitramide in the Drinking Water |
NOV 1995 |
27 pages |
| Authors:
Edwin R. Kinkead; Robin E. Wolfe; Marcia L. Feldmann; MANTECH ENVIRONMENTAL TECHNOLOGY INC DAYTON OH
|
| Ammonium dinitramide (ADN) is a class 1.1 explosive oxidizer, which may be used in solid rocket propellant mixtures and explosives. A 90-day general toxicity/reproductive screen performed on this compound at doses of 162, 103, 29, and 0.0 mg ADN)kg/day resulted in a treatment-related adverse effect on litter production. |
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| Species Profiles: Life Histories and Environmental Requirements of Coastal Fishes and Invertebrates (Mid-Atlantic). Bay Anchovy |
FEB 89 |
|
| Authors:
Timothy Morton; David Moran; NATIONAL WETLANDS RESEARCH CENTER SLIDELL LA
|
| Species profiles are literature summaries of the taxonomy, morphology, range, life history, and environmental requirements of coastal aquatic species. They are prepared to assist in environmental impact assessment. The bay anchovy, Anchoa mitchilli, is one of the most important species in the Mid-Atlantic Region because it is a primary forage item for many economically important commercial and sport fishes. Bay anchovies are ubiquitous inhabitants of the Mid-Atlantic Region. In this ... |
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| Lenticular Opacities and the Evaluation of Personnel for the Naval Nuclear Propulsion Program |
01 AUG 1974 |
34 pages |
| Authors:
Philip R. Albert; NAVAL SUBMARINE MEDICAL RESEARCH LAB GROTON CT
|
| Pertinent aspects of lens anatomy, embryology, and physiology are reviewed. Types of cataracts are described and classified as to etiology. The pathophysiology of radiation cataracts is discussed and data regarding dose levels needed to produce such cataracts is presented. The requirements for satisfactory screening for lenticular opacities and for their further evaluation is discussed in light of results achieved at the Nuclear Power Schools. Medicolegal ramifications are discussed and compensation ... |
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| Electron Microscope Data on the Development and Structure of the Retina, |
16 NOV 1973 |
|
| Authors:
R. O. Oganesyan; ARMY FOREIGN SCIENCE AND TECHNOLOGY CENTER CHARLOTTESVILLE VA
|
| A review of the investigations on the structure and function of an optical analyzer is given. The investigation was conducted by using the modern electron microscopic, cytochemical and biochemical methods. The translation was accomplished from a zerox manuscript. The graphics were not reproducible. An attempt to obtain the original graphics yielded negative results. Thus, this document was published as is, in order to make it available on a timely basis. ... |
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| Two Cases of Congenital Coloboma of the Optic Disc, |
MAY 1972 |
|
| Authors:
C. T. Kim; P. T. Hung; DEFENCE RESEARCH INFORMATION CENTRE ORPINGTON (ENGLAND)
|
| Coloboma of the optic nerve head is a rare anomaly resulting from disturbance by fusion of the optic cleft. It thus belongs to the so-called typical colobomas. This anomaly may be present as a single anomaly or associated with other anomalies elsewhere of the eye structures, especially of the fundus. The two cases reported in this paper are young males with the cheif complaints of defect of vision in one ... |
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| The Effect of Hypoxia on Isonicotinic Acid Hydrazide-Induced Seizures in Chicks during Ontogenesis, |
10 MAR 1971 |
|
| Authors:
J. D. Wood; S. J. Peesker; SASKATCHEWAN UNIV SASKATOON DEPT OF BIOCHEMISTRY
|
| The concentration of gamma-aminobutyric acid (GABA) in the brain of various species is elevated by hypobaric hpoxia, or by hypoxia caused by the breathing at ambient pressure of a gas mixture of low oxygen content. Hypobaric hypoxia also delays the onset of semi-carbazide- and methionine sulphoximine-induced seizures and it has been suggested that the elevation in brain GABA level may be responsible for the anticonvulsant action. Although the above studies ... |
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| Embryogenesis and Production of Albino Plants from Cell Cultures of 'Bromus inermis', |
10 SEP 1970 |
|
| Authors:
Oluf L. Gamborg; F. Constabel; R. A. Miller; NATIONAL RESEARCH COUNCIL OF CANADA SASKATOON (SASKATCHEWAN) PRAIRIE REGIONAL LAB
|
| Embryogenesis occurs in cells from brome grass grown in suspension culture in defined medium. Exogenous hormones are not required. The embryos develop into plants which lack chlorophyll. (Author) |
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| MORPHOLOGICAL CORRELATIONS INVOLVED IN THE DIFFERENTIATION OF THE EYE LENS. |
15 MAY 1969 |
|
| Authors:
Jose Ma Genis-Galvez; GRANADA UNIV (SPAIN) DEPARTAMENTO DE ANATOMIA; GRANADA UNIV (SPAIN) DEPARTAMENTO DE ANATOMIA
|
| On the basis of immunological techniques, cellulose acetate and starch gel electrophoresis, differences in macromolecular composition of the lens cells were detected in correlation with the age and cytological differentiation. From the three major groups of soluble lens proteins; alpha, beta, and delta crystallins; the last fraction should apparently be considered as a transient antigen. In fact, delta crystallin progressively disappears from the equatorial and cortical cells in ... |
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| STUDIES ON THE EMBRYOLOGY, PIGMENTS AND GLUCOSE METABOLISM OF THE marine borer, BANKIA SETACEA. |
25 APR 1969 |
|
| Authors:
Cecil C. Walden; BRITISH COLUMBIA RESEARCH COUNCIL VANCOUVER
|
| B. setacea was reared in the laboratory, from the germ cell stage to larval metamorphosis. Asepsis, by tissue culture techniques and antibiotics, was essential. Sexual differences in exhalant siphons of B. setacea were observed, as well as instances of internal fertilization. Fertilized ova are more dense than sea water. Certain external conditions, particularly salinites below 12 o/oo, caused loss of control of organized development in fertilized ova. Large masses of ... |
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| Development in Vitro of 'Half Eggs' and Single Blastomeres Isolated from Two-, Four-, and Eight-Cell Mouse Ova |
Dec-1968 |
19 pages |
| Authors:
James R Spears; Jerry S Walker; FORT DETRICK FREDERICK MD
|
| The extent of mouse blastomere lability was studied by isolating and growing in vitro blastomeres as various components of two-, four-, and eight- cell ova. The results were in accord with the view that blastomeres of the eight-cell ovum and possibly even later stages have the capability of becoming either trophoblast or inner cell mass, depending on location in the cell aggregate at the time of blastulation. The formation of ... |
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| INVESTIGATIONS IN THE FIELD OF RELATIONAL BIOLOGY. |
MAR 1967 |
|
| Authors:
Robert Rosen; CHICAGO UNIV ILL COMMITTEE ON MATHEMATICAL BIOLOGY
|
| A variety of results dealing with questions arising in the relational theory of cellular systems are briefly described. They bear on the construction of a general theoretical formalism encompassing all aspects of regulation and control of cellular processes in a unified fashion, and on the testing of this formalism on a specific experimental system (namely, on pattern generation and cell sorting in cultures of dissociated embryonic cells). (Author) |
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| RADIOSENSIBILITE ET POSSIBILITES DE RADIOPROTECTION DE LA LACTICODESHYDROGENASE D'UN ORGANE EMBRYONNAIRE DE POULET CULTIVE IN VITRO (Radiosensitivity and Possibilities of Shielding the Lactic Dehydrogenase of an Embryonic Chick Organ in Vitro), |
1967 |
|
| Authors:
J. M. Kirrmann; COLLEGE DE FRANCE NOGENT-SUR-MARNE INSTITUT D'EMBRYOLOGIE EXPERIMENTALE
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| DEVELOPMENT OF SKELETAL MUSCLE. |
15 MAR 1966 |
|
| Authors:
Maria Antonieta Rebollo; UNIVERSIDAD DE LA REPUBLICA MONTEVIDEO (URUGUAY) INSTITUTO DE NEUROLOGIA
|
| The morphological and histochemical study of the development of skeletal muscle in chick and rat embryos was continued. Features of the muscle growth mechanism, growth curves of fibers and degenerative phenomena in morphogenesis are discussed. Lipases, diaphorases and linked-dehydrogenases were studied and the parallelism of findings with lipids is demonstrated. An ultrastructural study of the chick showed special type sensory ending, different from mammals; 3 types of introfusal fibers. Established ... |
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| AN ITERATED NET MODEL OF THE VERTEBRATE COMMAND AND CONTROL SYSTEM. |
01 MAR 1966 |
|
| Authors:
W. L. Kilmer; MICHIGAN STATE UNIV EAST LANSING DIV OF ENGINEERING RESEARCH
|
| An eigenstate approach to the problem of stable biosynthetic mode points in cells is considered. This problem is cybernetically dual to the reticular formation one of passing from stable mode point to stable mode point under input provocation. The report also discusses a theory of the reticular formation. Throughout the life of the vertebrates, the core of the central nervous system, sometimes called the reticular formation, has retained the power ... |
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| THE PROBLEM OF CANCER IN LIGHT OF EMBRYOLOGICAL DATA, |
19 NOV 1964 |
|
| Authors:
M. P. SHABAD-Ivanova; FOREIGN TECHNOLOGY DIV WRIGHT-PATTERSON AFB OHIO
|
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| THE HYPOTHALAMUS AND HORMONAL ACTIVITY. |
30 SEP 1964 |
|
| Authors:
G. W. Harris; OXFORD UNIV (ENGLAND)
|
| Contents: The release of luteinizing hormone (LH) in the rabbit; Investigation of the releasing factor content of portal vessel blood; Studies on ovulation in immature rats; A study of the concentration, and activity, of thyrotrophic hormone in blood; TSH in thyrotoxicosis; A comparative study of TSH and LATS; A study of placental embryology and TSH; A study of the blood level of thyrotrophic hormone in response to stress and electrical ... |
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| Annual (Final) Report. (Neurobiology, Cell Ultrastructure, Biophysics and Electrophysiology), |
JUL 1964 |
|
| Authors:
J. SAS; C. Appeltauer; C. Estable; E. Silva; O. vincent; INSTITUTO DE CIENCIAS BIOLOGICAS MONTEVIDEO (URUGUAY)
|
| Reports on the following topics are summarized: neurobiology, cell ultrastructure, nerve regeneration, and conditioned reflexes. |
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| FORT DETRICK THESAURUS PROJECT. |
09 OCT 1963 |
|
| Authors:
GENERAL ELECTRIC CO WASHINGTON D C
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| NEUROANATOMY AND EMBRYOLOGY OF MARINE MAMMALS |
1963 |
4 pages |
| Authors:
John G. Sinclair; TEXAS UNIV MEDICAL BRANCH AT GALVESTON
|
|
| Conference on the Problem of Physiological Regeneration - USSR |
01 NOV 1960 |
29 pages |
| Authors:
I. A. Utkin; N. P. Bochkov; JOINT PUBLICATIONS RESEARCH SERVICE ARLINGTON VA
|
|
| News of Soviet Medical Sciences |
22 JUL 1960 |
11 pages |
| Authors:
JOINT PUBLICATIONS RESEARCH SERVICE ARLINGTON VA
|
| The following are translations of two articles taken from the Russian-language periodical Arkhiv anatomii1 gistologii i embrioloii (Archives of Anatomy, Histoloy, and Embryoiogy), Moscow-Leningrad, Vol. IWIlI, No. 1, January 1960. Source data on the individual articles. |
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| Determination and Plasticity of Skin Under Normal, Experimental, and Pathological Conditions |
28 APR 1960 |
|
| Authors:
Ye S. Gerlovin; JOINT PUBLICATIONS RESEARCH SERVICE ARLINGTON VA
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| Soviet Reports on Scientific Progress in China (Translation) |
02 MAR 1960 |
12 pages |
| Authors:
P. A. Rebinder; Ye. D. Shchukin; T. A. Detlaf; JOINT PUBLICATIONS RESEARCH SERVICE ARLINGTON VA
|
| This document is a translation from Vestnik Akademii Nauk SSSR (herald of the Academy of Sciences USSR) concerning Soviet reports on scientific progress in China. Some topics discussed in the reports are examples of scientific cooperation between USSR and China and recent achievements in the work of Chinese embryologists. ANNOTATION: Soviet Reports on Scientific Progress in China (Translation). -- Translation. |
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| THE LOGICAL STRUCTURE OF MIND. AN INQUIRY INTO THE PHILOSOPHICAL FOUNDATION OF PSYCHOLOGY AND PSYCHIATRY, |
Mar-1934 |
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| Authors:
Von; Eilhard Domarus; Warren S mcCulloch; MASSACHUSETTS INST OF TECH CAMBRIDGE RESEARCH LAB OF ELECTRONICS
|
| The history of both physics and mathematics shows that the only escape from an antiquated metaphysic is into the metaphysic subsumed by the systematic context of the symbols requisite to convey experience in its achieved distinction. In the so-called mental sciences the necessity of this process becomes obtrusive. Chapter one of this paper is the description of it as obvious in psychology; chapter two, of its subtle appearance culminating in ... |
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Reports by Keyword(s)
EMBRYOLOGY
