| Development of a Versatile Conditioning Wind Tunnel for Evaporative Fate Studies |
Oct-2009 |
63 pages |
| Authors:
H D Durst; James E Danberg; Daniel J Weber; Daniel Waysbort; Clayton S Moury; EDGEWOOD CHEMICAL BIOLOGICAL CENTER ABERDEEN PROVING GROUND MD
|
 | This report documents the development of a conditioning wind tunnel that allows multiple test samples to be conditioned at identical environmental settings that are used in smaller vapor sampling wind tunnels. The conditioning of multiple samples, especially those involving persistent chemicals, allows for the efficient use of a limited number of instrumented vapor sampling tunnels. Up to nine samples can be sequentially and quickly cycled through the instrumented vapor wind ... |
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| Probabilistic Treatment of Airlift Delivery |
Sep-2009 |
|
| Authors:
W L Greer; A I Kaufman; INSTITUTE FOR DEFENSE ANALYSES ALEXANDRIA VA
|
 | Traditionally, a deterministic simulation is used to estimate airborne cargo and passenger delivery in wartime scenarios. Deterministic models address reliability by removing the number of non-mission capable aircraft from the total possessed numbers at the very beginning of the delivery process. Only mission capable (MC) aircraft, minus any special mission withholds, are used in the model. Most important, once an aircraft is deemed to be MC, it never fails anywhere ... |
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| Sun Sensor Calibration for the Calibrated Orbiting Objects Project (COOP) |
30-Jul-2009 |
34 pages |
| Authors:
Chantel Evans; Whitney Whetten; AIR FORCE RESEARCH LAB KIRTLAND AFB NM SPACE VEHICLES DIRECTORATE
|
| This Technical Note describes the calibration of the coarse and medium sun sensors for the Calibrate Orbiting Objects Project (COOP). The data presented will be used by the satellite contractor for Attitude Determination and Control (ADC). The coarse sensors were calibrated at 15 deg increments along orthogonal axes within its 120 deg field of view (FOV) and the medium sensors were calibrated at 10 deg increments along orthogonal axes within ... |
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| Determination of Critical Factors in Unmanned Casualty Evacuation in the Distributed Environment |
Jun-2009 |
67 pages |
| Authors:
Ralph L Featherstone; NAVAL POSTGRADUATE SCHOOL MONTEREY CA
|
| The current battlefield is changing rapidly. Combat operations against irregular forces are set in a dispersed, non-linear battlefield. Vast distances between small units such as the infantry squad, and the distances from these small elements to their supporting organizations, pose unique challenges. Casualty evacuation is an evolving challenge. The goal of casualty evacuation is to transport an injured Marine from the point of injury to a medical care facility. Increased ... |
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| Transport Imaging: Developing an Optical Technique to Characterize Bulk Semiconductor Materials for Next Generation Radiation Detectors |
Jun-2009 |
79 pages |
| Authors:
Sarah L Catalano; NAVAL POSTGRADUATE SCHOOL MONTEREY CA
|
| Characterization of the mobility-lifetime product is critical to the development of new materials for semiconductor radiation detectors. An optical technique has been developed that allows for the direct determination of the minority carrier diffusion length, drift length, and mobility-lifetime product from a single image of the recombination luminescence in semiconductor materials. Excess carriers are generated using the electron beam in a scanning electron microscope. The charge is then drifted by ... |
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| Utilization of Non-Destructive Tools for In-Situ Determination of Hydrogen Content in Advanced Materials |
Feb-2009 |
32 pages |
| Authors:
Angelique Lasseigne; Kamalu Koenig; David L Olson; Joshua Jackson; Brajendra Mishra; GENERATION 2 MATERIALS TECHNOLOGY LLC FIRESTONE CO
|
| OUTLINE: Introduction; Common Factor Between Electronic Tools and Hydrogen Measurement; Non-Destructive Hydrogen Content Sensors; Thermoelectric Power Measurements; Low Frequency Impedance Measurements; Results; Summary. |
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| In-Orbit Performance Assessment of Giove Clocks |
01-Dec-2008 |
15 pages |
| Authors:
Pierre Waller; P Tavella; I Sesia; G Tobias; I Hidalgo; R Piriz; S Binda; J Hahn; F Gonzalez; G Cerretto; EUROPEAN SPACE AGENCY NOORDWIJK (NETHERLANDS)
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| Two onboard atomic clock technologies have been developed for the Galileo system, one based on vapor cell rubidium technology (RAFS: Rubidium Atomic Frequency Standard) and one based on passive hydrogen maser (PHM) technology. In the years 2004-2005, both technologies have successfully passed a full qualification campaign (including shock, vibration, thermal vacuum, ...) aimed at verifying their performance in a Galileo-like environment. In the year 2005, six RAFS and two PHM ... |
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| Determination of Cost Drivers for Ship Operations (1B1B) Consumable (SO) Operations Target Accounts for Amphibious Assault Ships |
Dec-2008 |
99 pages |
| Authors:
Brett M Sullivan; NAVAL POSTGRADUATE SCHOOL MONTEREY CA
|
| This thesis conducts an analysis of Amphibious Assault ships consumable ship's OPTAR disbursements for the period of 1 July 2007 to 30 April 2008. Regression analysis was used to test for a statistical relationship among total monthly disbursements by Federal Supply Group (FSG) code and various demographic information, monthly maintenance (MFOM) and training figure of merit (TFOM) scores. Monthly disbursements were aggregated by total monthly FSG investment for each ship ... |
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| The Collins Center Update, (CSL Issue Paper, Volume 11, Issue 1, October-December 2008) |
Dec-2008 |
5 pages |
| Authors:
Ritchie Dion; ARMY WAR COLL CARLISLE BARRACKS PA CENTER FOR STRATEGIC LEADERSHIP
|
| This year CSL continued to enhance its partnerships with Georgetown University and the George H. W. Bush School of Government and Public Service, part of the Bush Presidential Library at Texas A&M University. The primary vehicle for these partnerships continues to be a strategic- level negotiations exercise conducted for Masters Degree students at each school. As in the past, the USAWC?s International Fellows Strategic Crisis Negotiation Exercise served as the ... |
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| Deterministic Entangled Nanosource |
Aug-2008 |
10 pages |
| Authors:
Galina Khitrova; ARIZONA UNIV TUCSON
|
| During the three years of this grant, conclusions were reached that are important for the future of semiconductor cavity QED utilizing photonic crystal nanocavities. A new way was found to scan the cavity mode by condensation of xenon or nitrogen while keeping the quantum dot cold to minimize dephasing. Absorption was shown to reduce the cavity Q when the dot density is 400 per square micron. Lasing with a soft ... |
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| Miniature Rotorcraft Flight Control Stabilization System |
30-May-2008 |
39 pages |
| Authors:
Nathan Slegers; ALABAMA UNIV IN HUNTSVILLE
|
| Attitude determination algorithms for a small rotorcraft are proposed and compared. The first algorithm is based on the well known QUEST algorithm used for spacecraft and satellites Due to large vibration in sensors a pseudo-measurement is developed from gyroscope measurements and rotational kinematics. The pseudo-measurement is used within QUEST to smooth attitude estimations A second simple gyro-compensated tilt sensor and compass is proposed and compared to the optimal QUEST solution. ... |
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| Determining the Capability Requirements for a Space-Based Optical Sensor to Determine the Trajectory of an Incoming Antisatellite Weapon |
01-Mar-2008 |
131 pages |
| Authors:
Mesut Guelmuesh; AIR FORCE INST OF TECH WRIGHT-PATTERSON AFB OH SCHOOL OF ENGINEERING AND MANAGEMENT
|
| The goal of this research is to build up a logic to catch and track the incoming ASAT weapons by using space-based onboard optical sensors. The satellite orbit and ASAT trajectory of the Chinese test were generated to relate the research to the real world application. These position and velocity values are used to generate simulated observation data for the imaginary sensor on the targeted satellite. These observation values are ... |
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| Advanced Narrowband Electromagnetic Size and Shape Determination |
15 FEB 2008 |
|
| Authors:
S. Kusiak; MASSACHUSETTS INST OF TECH LEXINGTON LINCOLN LAB
|
| This report discusses a fundamental radar imaging problem for narrowband electromagnetic waves that extends the recent results originally obtained in [1, 2] in the scalar, or acoustic, setting. In particular we demonstrate the ability to efficiently image three-dimensional convex conducting bodies by using the knowledge of the scattered electric field for one fixed monochromatic illumination of the target. In this problem our knowledge of the scattered electric wave is understood ... |
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| Grazing Impacts of Diverse Zooplankton Taxa on Thin Layers |
Jan-2008 |
8 pages |
| Authors:
Stephen M Bollens; Gretchen Rollwagen-Bollens; WASHINGTON STATE UNIV VANCOUVER
|
| The US Navy needs to know how distributions and abundances of light-scattering and sound-scattering organisms in the ocean vary in space and time, particularly in the vertical dimension. Recent field observations have shown that many biological properties may vary substantially over small (e.g. centimeter) scales, commonly referred to as thin layers. Our previous ONR-funded research has allowed us to begin to understand how zooplankton interact with thin layers and how ... |
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| Transport Imaging for the Study of Nanowires and Related Nanostructures |
DEC 2007 |
105 pages |
| Authors:
Ang G. Hwee; NAVAL POSTGRADUATE SCHOOL MONTEREY CA
|
| The goals of this thesis are to demonstrate the operation of a near-field scanning microscope (NSOM) inside a scanning electron microscope (SEM) to collect spatially resolved luminescence and to image transport on nano-scale structures particularly nanowires. The SEM is used to generate localized charge and the NSOM is used to observe the motion of the excess charge due to diffusion and/or drift via its recombination emission. This will allow direct ... |
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| Multimodal Guidance for Land Navigation |
OCT 2007 |
67 pages |
| Authors:
Linda R. Elliott; Maaike Duistermaat; Elizabeth S. Redden; Jan van Erp; ARMY RESEARCH LAB ABERDEEN PROVING GROUND MD HUMAN RESEARCH AND ENGINEERING DIRECTORATE
|
| This report describes the third in a series of collaborative experiments between the U.S. Army Research Laboratory and TNO Human Factors (Soesterberg, The Netherlands). In each experiment, a personal tactile navigation (PTN) system for land navigation was compared with alternate land navigation systems in wooded terrain at Fort Benning, Georgia, during high workload conditions that included secondary tasks such as radio communications, target detection, and determination of location coordinates. This ... |
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| Characterization, Optimization, and Test of the NPSAT1 MEMS 3-Axis Rate Sensor Suite for Use in Small Satellite Attitude Control |
SEP 2007 |
227 pages |
| Authors:
Thomas S. Pugsley; NAVAL POSTGRADUATE SCHOOL MONTEREY CA
|
| The NPSAT1 project is a Naval Postgraduate School (NPS) educational small satellite combining student education in satellite systems and operations, institutional research, and sponsored experiments with the objective of testing technologies for applications in space flight. The micro-electro-mechanical system (MEMS) rate sensor is one of these experimental technologies. Packaging three of these MEMS sensors together makes a 3-axis rate sensor suite. The MEMS experiment was originally conceived of as a ... |
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| Determination of Primary Bands for Global Ocean-Color Remote Sensing |
AUG 2007 |
9 pages |
| Authors:
ZhongPing Lee; Robert Arnone; Kendall Carder; MingXia He; NAVAL RESEARCH LAB STENNIS SPACE CENTER MS OCEANOGRAPHY DIV
|
| A few years ago, Lee and Carder' demonstrated that for the quantitative derivation of major properties in an aqua-environment (information of phytoplankton biomass, colored dissolved organic matter, and bottom status, for instance) from remote sensing of its color, a sensor with roughly 17 spectral bands in the 400 - 800 nm range can provide acceptable results compared to a sensor with 81 consecutive bands (in a 5-nm step). In that ... |
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| The Value of Numerical Forecast Products in Improving Tactical Air Delivery Methods |
JUN 2007 |
103 pages |
| Authors:
Michael Rost; NAVAL POSTGRADUATE SCHOOL MONTEREY CA
|
| This thesis investigates the development of an agent-based system to analyze meteorological model data and generate statistics for comparison purposes. With it, it is possible to research the value and level of improvement when utilizing different levels of atmospheric-model resolution for guidance in tactical decision aids. Our agent-based system automates the comparison of model data at a location in the model field with environmental data extracted from sensor data obtained ... |
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| Time-Resolved and Spectroscopic Three-Dimensional Optical Breast Tomography |
APR 2007 |
36 pages |
| Authors:
Robert R. Alfano; STATE UNIV OF NEW YORK
|
| The research carried out during the current reporting period included: (a) Use of optical tomographic imaging using independent component analysis (OPTICA) developed during the first reporting period to image targets in ex vivo breast tissue specimens, (b) Extension of OPTICA for obtaining cross sectional image of targets in turbid media, (c) (d) Development of a forward model for scattered light intensity distribution in the backscattering geometry; and (e) Development of ... |
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| Scalability, Complexity and Reliability in Quantum Information Processing |
MAR 2007 |
72 pages |
| Authors:
Dan Stamper-Kurn; Umesh Vazirani; David Weiss; K. B. Whaley; CALIFORNIA UNIV BERKELEY
|
| This program was a theory/experiment collaboration focusing on the fundamental need for scalability in the development of quantum information processing. Theory and experiment were connected and interleaved at several levels. The theory objectives were 1) to develop new theoretical tools to enable the implementation of reliable quantum information processing in scalable systems and 2) to characterize the relations between quantum algorithms and architectures, between fault tolerance and architectures, between quantum ... |
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| In Vivo Determination of the Complex Elastic Moduli of Cetacean Head Tissue |
Jan-2007 |
12 pages |
| Authors:
Peter H Rogers; David H Trivett; GEORGIA INST OF TECH ATLANTA SCHOOL OF MECHANICAL ENGINEERING
|
| The overall goal of this project is to determine the feasibility of in vivo, non-invasive measurement of the complex elastic moduli of cetacean head tissue. If this objective is met, measurement systems could be developed capable of measuring the complex elastic moduli of the head tissue of live, stranded cetaceans. The technical objective is to remotely generate and detect mid-frequency (1 to 10 kHz) elastic waves within the body of ... |
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| Multifactorial Assessment of Depleted Uranium Neurotoxicity |
DEC 2006 |
121 pages |
| Authors:
Bernard S. Jortner; VIRGINIA POLYTECHNIC INST BLACKSBURG
|
| THIS WAS A 5-YEAR PROJECT TO EXPERIMENTALLY ASSESS THE NEUROTOXICOLOGIC POTENTIAL OF EXPOSURE TO DEPLETED URANIUM (DU), AND THE ROLE OF STRESS IN ALTERING THE TOXICITY. THE PROJECT INVOLVED DETERMINATION OF THE TOXICOKINETICS OF DU IN THE BRAIN, DEVELOPMENT OF A RELEVANT STRESS MODEL, AND STUDY OF NEUROTOXIC EFFFECTS OF A SINGLE (ACUTE) EXPOSURE TO SOLUBLE DU AND TO LONG-TERM EXPOSURE TO IMPLANTED PELLETED DU, AND THEIR MODIFICATION BY STRESS. ... |
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| Ballistic Missile Trajectory Estimation |
DEC 2006 |
77 pages |
| Authors:
Joseph Dituri; NAVAL POSTGRADUATE SCHOOL MONTEREY CA
|
| Angles measurements from optical systems are the primary source of data for maintaining the orbits of high altitude satellites. Radar measurements are used primarily for low Earth orbit (LEO) satellites. Recently it has been shown that the accuracy of the orbit updates using only optical system angles-only data is just as good, if not better, than the performance from radar systems for LEO satellites. The purpose of this thesis is ... |
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| Derivation of a Theory to Estimate the Kinetic Parameters for Systems with Multiple Substrates Competing for the Same Active Site on an Enzyme |
Dec-2006 |
20 pages |
| Authors:
J R Smith; Richard E Sweeney; David T Yeung; Douglas M Cerasoli; Donald M Maxwell; David E Lenz; ARMY MEDICAL RESEARCH INST OF CHEMICAL DEFENSE ABERDEEN PROVING GROUND MD
|
| In studies to characterize the kinetic parameters for catalytic hydrolysis of the organophosphorus nerve agent 1,2,2-trimethylpropyl methylphosphonofluoridate (GD) by human paraoxonase (HuPON1), it was found that standard analysis techniques could not be employed because the kinetic parameters for the GD isomers were not significantly different from each other. Separation of the racemic mixture into component stereoisomers for individual study is feasible but extremely expensive. It was recognized that a theory ... |
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| Deployment and Intelligent Nanosatellite Operations Colorado Final Technical Report |
28 SEP 2006 |
191 pages |
| Authors:
Elaine Hansen; Dave Beckwith; Christ Koehler; Steve Levin-Stankevich; Jennifer Michels; Steve Wichman; COLORADO UNIV AT BOULDER
|
| The main purpose of the DINO satellite was to generate topographic maps of the tops of clouds through stereoscopic imaging based on photographs from the on-board digital cameras, with most processing done on the satellite itself. The attitude determination and control system was designed to be responsible for maintaining the spacecraft's orientation in order to achieve mission objectives. The system consisted of a magnetometer and three single axis rate gyroscopes. ... |
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| A Comparison of Trajectory Determination Approaches for Small UAVs |
SEP 2006 |
14 pages |
| Authors:
Murray B. Anderson; Juan L. Lopez; Johnny H. Evers; AIR FORCE RESEARCH LAB EGLIN AFB FL MUNITIONS DIRECTORATE
|
| In considering the problem of small unmanned aerial vehicle (SUAV) surveillance mission in a target rich environment, it is desirable to follow a trajectory path that maximizes targets coverage and observation time, while minimizing airframe maneuvering. Motivated by this requirement, this paper investigates the merits of multiple vehicle trajectory path schemes. Genetic Algorithms (GAs) and local optimum techniques are compared to a more conventional defined-path approach. The authors also introduce ... |
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| Space Weather Applications of the UAF Eulerian Parallel Polar Ionosphere Model (EPPIM) |
01 JUN 2006 |
15 pages |
| Authors:
Sergei Maurits; Anton Kulchitsky; Brenton Watkins; ALASKA UNIV FAIRBANKS
|
| UAF EPPIM is the first principles theoretical model of the polar ionosphere, which covers region pole ward from 50 N of geomagnetic latitude, and altitudes from 80 to 900-1000 km. If available, the model can input real data or, conversely, it is capable of generating all necessary inputs using statistical modules (e.g., MSIS, electric field, precipitation intensity, etc.) incorporated into the model and driven by the standard set of geophysical ... |
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| Morphology of Southern Hemisphere Riometer Auroral Absorption |
01 JUN 2006 |
51 pages |
| Authors:
A. J. Foppiano; UNIVERSIDAD DE CONCEPCION (CHILE) DEPARTAMENTO DE GEOFISICA
|
| A morphology of riometer auroral absorption is derived from hourly values, determined at several Southern Hemisphere stations, located both near the centre of the auroral absorption zone and at higher and lower latitude fringes of the zone. Since spatial coverage of the data precludes a detailed morphology determination, use was made as guideline at all stages of an auroral absorption model derived for the Northern Hemisphere (NH). The day-to-day variability ... |
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| Towards Determination of Visual Requirements for Augmented Reality Displays and Virtual Environments for the Airport Tower |
01 JUN 2006 |
29 pages |
| Authors:
NATIONAL AERONAUTICS AND SPACE ADMINISTRATION MOFFETT FIELD CA AMES RESEARCH CENTER
|
| The visual requirements for augmented reality or virtual environments displays that might be used in real or virtual towers are reviewed with respect to similar displays already used in aircraft. As an example of the type of human performance studies needed to determine the useful specifications of augmented reality displays, an optical see-through display was used in an ATC Tower simulation. Three different binocular fields of view (14 , 28 ... |
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| A Model for the Ordering and Distribution of the Influenza Vaccine |
JUN 2006 |
69 pages |
| Authors:
James R. Gurr; NAVAL POSTGRADUATE SCHOOL MONTEREY CA
|
| The system for the production and distribution of the United States supply of influenza vaccine has experienced disruptions during past influenza seasons. The identification of elements of the influenza vaccine is different each year and must be researched and identified each year prior to the influenza season. The manufacturing of the vaccine is a complicated process with many potential problems. This thesis identifies the requirements and constraints of the current ... |
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| Inhibitors of Histone Deacetylases for Radiosensitization of Prostate Cancer |
APR 2006 |
9 pages |
| Authors:
Mira O. Jung; GEORGETOWN UNIV WASHINGTON DC
|
| Failure of conventional treatment of prostate cancer with radiotherapy may be due to intrinsic resistance of the tumor cells. One of mechanisms underlying intrinsic radiation sensitivity is linked to the state of chromatin architecture. The long-term goal of this proposal is to develop a novel therapeutic strategy by enhancing radiosensitivity of prostate cancer cells by testing the hypothesis that an increase of cellular radiation sensitivity may be achieved by exposure ... |
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| Determination of Changes in the State of the Arctic Ice Pack Using the NPS Pan-Arctic Coupled Ice-Ocean Model |
MAR 2006 |
75 pages |
| Authors:
Terry McNamara; NAVAL POSTGRADUATE SCHOOL MONTEREY CA UNDERSEA WARFARE ACADEMIC GROUP
|
| This thesis provides an analysis of the diminishing sea ice trend in the Arctic Ocean by examining the NPS 1/12-degree pan-Arctic coupled ice-ocean model. While many previous studies have analyzed changes in ice extent and concentration, this research focuses on ice thickness as it gives a better indication of ice volume variability. The skill of the model is examined by comparing its output to sea ice thickness data gathered during ... |
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| Cycle Criteria for Detection of Camouflaged Targets |
01 DEC 2005 |
24 pages |
| Authors:
Barbara L. O'Kane; Gary L. Page; David L. Wilson; David J. Bohan; ARMY COMMUNICATIONS-ELECTRONICS RESEARCH DEVELOPMENT AND ENGINEERING CENTER FORT BELVOIR VA
|
| The interplay between sensors and camouflage has long presented a problem for modeling target acquisition performance of human-in-the-loop thermal sensors. For instance, ACQUIRE, a commonly used target acquisition model, is relatively more sensitive to target size than target contrast. The result is that ACQUIRE generally predicts that low contrast targets will be detected at ranges similar to baseline targets. Thus ACQUIRE has had limited success for camouflage evaluation, since it ... |
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| Multi-Image Road Extraction |
22 NOV 2005 |
|
| Authors:
W. A. Harvey; Steven D. Cochran; David M. McKeown; CARNEGIE-MELLON UNIV PITTSBURGH PA DEPT OF COMPUTER SCIENCE
|
| Our research is focused on an investigation of automated road tracking using multiple images, toward a goal of fully automated extraction of 3D road networks with topology and attribution. The use of multiple images for road tracking makes the process more robust, due to analysis of the scene from different view points. It also supports direct extraction of 3D information along the path of the road. Determination of road elevation ... |
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| Structure-based Design of Cdk4/6-Specific Inhibitors |
OCT 2005 |
15 pages |
| Authors:
Ronen Marmorstein; PENNSYLVANIA UNIV PHILADELPHIA WISTAR INST
|
| The CDk4/6 kinase has elevated activity in spontaneous breast cancer, making it an excellent candidate for targeted inhibition for the treatment of breast cancer. We propose to prepare a CDK4/6-specific kinase inhibitor that is based on the naturally occurring CDK4/6 specific inhibitory proteins of the INK4 family. Since the INK4 proteins are notoriously unstable, we have been working towards the preparation and structural characterization of INK4 proteins with improved thermostability ... |
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| Orbit Determination of Highly Eccentric Orbits using a RAVEN Telescope |
SEP 2005 |
51 pages |
| Authors:
Michael L. Thrall; NAVAL POSTGRADUATE SCHOOL MONTEREY CA
|
| For the past eight years, the small automated telescope Raven has been tested in detecting and tracking deep space objects. As the Raven has proven successful in tracking this regular and predictable orbit, its one arc-second accuracy made it a perfect candidate to attempt to accurately track the less predictable Highly Eccentric Orbit (HEO) objects. Ranging data was obtained from the Sirius satellite radio company for the Sirius3 satellite (Satellite ... |
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| BRCA1 Mediated Ubiquitination: Identification of Targets for Destruction |
SEP 2005 |
16 pages |
| Authors:
Lea Starita; Jeffrey Parvin; BRIGHAM AND WOMEN'S HOSPITAL BOSTON MA
|
| I have made considerable progress on the research project that I outlined in the pre-doctoral DOD breast cancer research fellowship proposal. The proposal aimed to determine targets for the ubiquitin ligase activity of BRCA1. BRCA1 (Breast Cancer susceptibility gene 1) is an important tumor suppressor that protects mammary cells from malignant transformation. Recently BRCA1 has been found to have an enzymatic function as an ubiquitin ligase. Ubiquitin ligases tag other ... |
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| Structural Determination of Certain Novel ER Complexes |
SEP 2005 |
27 pages |
| Authors:
Ye-Ling Wu; CHICAGO UNIV IL
|
| Tamoxifen is effective for the prevention and treatment of estrogen-dependent breast cancers, but is associated with an increased incidence of endometrial tumors. I have completed the specific aims in this proposal including structural, biochemical and functional characterizations of estrogen receptor alpha (ERalpha) in complex with GW5638. This compound has a similar chemical structure to tamoxifen, but possesses a different pharmacological profile and has therapeutic potential for advanced breast cancers. The ... |
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| Targetable Polymer - Antiangiogenic Drug Conjugates for Systemic Breast Cancer Therapy |
SEP 2005 |
19 pages |
| Authors:
Anjan Nan; MARYLAND UNIV BALTIMORE
|
| The overall purpose of this project is to develop targetable water-soluble polymerantiangiogenic drug conjugates for systemic breast cancer therapy. The rationale is that by selectively targeting polymer-antiangiogenic drug conjugates to alpha-v-beta-3 receptors on endothelial cells of tumor neovasculature; it is possible to restrict the biodistribution of the antiangiogenic drug to the vascular space, thereby increasing tumor accumulation and subsequent antitumor potency of the drug and decreasing dose-limiting toxicity. In year ... |
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| Attitude Determination for the Three-Axis Spacecraft Simulator (TASS) by Application of Particle Filtering Techniques |
JUN 2005 |
91 pages |
| Authors:
Ioannis Kassalias; NAVAL POSTGRADUATE SCHOOL MONTEREY CA
|
| The accurate determination of spacecraft attitude has always been a critical issue in many applications. The presence of imperfect sensors introduces errors in the system and affects the outcome of the mission. One of the most significant sensors is the rate gyroscope. Particularly, the rate gyros are known to degrade with time, introducing random noise and bias. This calls for estimation algorithms which process the measured data in order to ... |
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| Geosynchronous Orbit Determination Using High Accuracy Angular Observations |
18 MAR 2005 |
17 pages |
| Authors:
Benjamin Visser; chris Sabol; Scott Dahlke; AIR FORCE ACADEMY COLORADO SPRINGS CO DEPT OF ASTRONAUTICS
|
| As part of the High Accuracy Network Determination System (HANDS), Raven-class telescopes were built to provide observations with less than an arcsecond of error. While achieving low noise levels, previous work has shown that HANDS optical data contain systematic errors which limit orbit determination accuracy; therefore, the challenge is being able to fully utilize that data to produce deep-space orbits with great certainty. This paper presents findings that better define ... |
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| A Mechanical Loading/Synchrotron X-Ray Diffraction System for In-Situ Determination of Lattice Strains |
MAR 2005 |
9 pages |
| Authors:
Matthew Miller; Paul Dawson; CORNELL UNIV ITHACA NY OFFICE OF SPONSORED PROGRAMS
|
| A mechanical testing/synchrotron x-ray diffraction system was fabricated in this DURIP grant. The key elements of the system are a high frequency uniaxial loading machine, a precision diffractometer support Unit and an x-ray shutter (chopper). The system will be employed within synchrotron experimental facilities to measure lattice strains during cyclic deformation experiments as a means to understand the evolution of crystal stresses. |
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| A Medical Research and Evaluation Facility (MREF) and Studies Supporting the Medical Chemical Defense Program |
MAR 2005 |
24 pages |
| Authors:
Carl T. Olson; Ryan James; James Botsford; Theresa Curtis; Frank Doherty; Donald Lush; Phil McFadden; Thomas O'Shaughnessy; Stanley States; Ryo Shoji; BATTELLE MEMORIAL INST COLUMBUS OH
|
| The U.S. Army Center for Environmental Health Research (USACEHR), a detachment of the U.S. Army Medical Research Institute of Chemical Defense, in collaboration with Battelle, has recently evaluated the use of 10 sensor technologies for rapid identification of toxicity in drinking water. The objective was to evaluate the ability of these sensors to respond rapidly (in less than an hour) to the presence of 12 industrial and agricultural chemicals. USACHER ... |
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| Center of Gravity Determination and Implications for the War Against Radical Islamic Terrorism |
23 FEB 2005 |
41 pages |
| Authors:
Tim Keppler; ARMY WAR COLL CARLISLE BARRACKS PA
|
| This paper examines Carl Von Clausewitz's center of gravity concept and applies it to the war against radical Islamic terrorism. It describes the confusion associated with the concept compares the current doctrinal definition of center of gravity with Clausewitz's likely intent and describes the concepts contemporary importance and applicability. It describes the nature of the threat to U.S. national interests posed by radical Islamic terrorists identifies the enemy and friendly ... |
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| Determinants of Productivity for Military Personnel. A Review of Findings on the Contribution of Experience, Training, and Aptitude to Military Performance |
2005 |
|
| Authors:
Jennifer Kavanagh; RAND NATIONAL DEFENSE RESEARCH INST SANTA MONICA CA
|
| The study of personnel characteristics, including aptitude, training, and experience, and their relationship with individual and unit performance is not just theoretical but has extensive practical import. More specifically, the significance of this area of research lies in its usefulness to the requirement determination, training/development, and recruitment and retention programs of the armed forces. Accurate data on the relationship between performance on the one hand and ability, experience, and training ... |
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| Metallurgical Factors Influencing Direct Laser Deposition of Metallic Powers for Unitized Structures |
2005 |
14 pages |
| Authors:
Hamish L. Fraser; James C. Williams; OHIO STATE UNIV COLUMBUS DEPT OF MATERIALS SCIENCE AND ENGINEERING
|
| The aim of this project is to investigate the possibility of making use of direct laser deposition techniques for the production of unitized structures. Specifically, the research is directed at determining the metallurgical factors that influence the process for this application. By so doing, it is intended to develop technologies which permit exploitation of the advantages of this processing technique. This research that has been performed during the scope of ... |
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| An Evaluation of Indirect Cost Rate Determination at the Naval Postgraduate School |
DEC 2004 |
85 pages |
| Authors:
Brant Clark; Michael J. Jones; Wendy J. Miller; NAVAL POSTGRADUATE SCHOOL MONTEREY CA
|
| Since its inception, faculty of the Naval Postgraduate School (NPS) have conducted research and development for the United States Navy, its sister military services, and other various agencies spread across the Federal Government. For its support of research efforts, NPS is reimbursed for actual costs incurred in association with providing research and development. Over the past several years the school has experienced a significant increase in the amount of reimbursable ... |
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| Cyclopentadienyl Rhenium (Technetium) Tricarbonyl Complexes Integrated in Estrogen Receptor Ligands for ER+ Tumor Imaging |
OCT 2004 |
8 pages |
| Authors:
Nathan C. Ackroyd; John A. Katzenellenbogen; ILLINOIS UNIV CHAMPAIGN
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| A class of breast tumors, known as ER+, contains significant concentrations of ER which functions to regulate cell growth, and mediate the action of estrogen antagonists. There is a need for the development non-invasive and reliable methods for the determination of tumor ER concentration in the identification of patients predicted to respond to hormone therapy. It has been shown that tumor ER concentration can be determined by imaging, using 18F- ... |
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| Broadband Plasma Impedance Measurements and Determination of Plasma Parameters |
20 SEP 2004 |
12 pages |
| Authors:
WIlliam E. Amatucci; David N. Walker; David D. Blackwell; NAVAL RESEARCH LAB WASHINGTON DC PLASMA PHYSICS DIV
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| A small spherical probe is used in conjunction with a network analyzer to determine the impedance of the probe-plasma system over a wide frequency range. Impedance curves are in good agreement with accepted circuit modes with plasma-sheath and electron plasma frequency resonances easily identifiable. Phase measurements show clear transitions between capacitive and inductive modes as predicted by the model. Sheath thickness and absolute electron density are determined from the location ... |
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