| New Polybenzimidazole Architectures by Diels Alder Polymerization |
14 Feb 2012 |
23 pages |
| Authors:
Douglas A Loy; ARIZONA UNIV TUCSON
|
 | Due to their high value as flame and heat resistant materials and high cost, improved methods for preparing polybenzimidazoles, particularly those with added substituent to improve processability. are desirable. This project was a proof of principle study to determine if Diels-Alder polymerization of monomers bearing imidazole and thiophene dioxide groups could be used to prepared polybenzimidazoles or related polymers. To this end. several new monomers were synthesized and polymerized. These ... |
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| Establishment of a Center for Development of Chemical Sensors for Explosives at University of Puerto Rico-Mayaguez |
08 FEB 2011 |
66 pages |
| Authors:
Samuel P. Hernandez-Rivera; PUERTO RICO UNIV MAYAGUEZ
|
| DoD-UPRM-MURI grant: "Establishment of a Center for Development of Chemical Sensors for Explosives at University of Puerto Rico - Mayaguez" (Proposal # 43567CHMUR; Agreement #: DAAD190210257) operated between 2002 and 2010. The project established a multidisciplinary research center for detection of land-mine explosives, focusing on spectroscopic signatures of land mines explosives and transport in soil, contributing to real time chemical sensing of land mines. Goals included: * Measurement of spectroscopic ... |
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| Common Trends in the Relationships Between Chemical and Physical Properties and Molecular Structure of Nitramine, Cage Nitramine, and Nitroaromatic Energetics |
Dec-2008 |
|
| Authors:
Mohammad Qasim; Jerzy Leszczynski; Leonid Gorb; Minori Uchimiya; Brett Moore; Lyssa Taylor; Matthew Middleton; ENGINEER RESEARCH AND DEVELOPMENT CENTER VICKSBURG MS
|
 | Chemical and physical properties of nitroaromatic and nitramine explosives were related to their molecular structure with the objective of predicting types, sites and rates of reactivity as well as prediction of transformation intermediate and final products, stability, and toxicity potential. Understanding these relationships is intrinsic to the development of computational chemistry (CC) protocols for basic research into new compounds as well as for specific applications to military sites. Our comparisons ... |
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| Functional Analysis of Human NF1 in Drosophia |
JAN 2006 |
21 pages |
| Authors:
Yi Zhong; COLD SPRING HARBOR LAB NY
|
| Neurofibromatosis type 1 (NF1) is characterized by benign but disfiguring skin tumors, pigmentation defects and learning disabilities, as well as increased risk of brain tumors. The NF1 tumor suppressor protein (neurofibromin) inhibits Ras, a protein that is overactive in a wide variety of human cancers. NF1 also controls levels of cyclic AMP, an important intracellular messenger involved in cell growth and learning. Over last year, we continue to examine the ... |
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| CRE Activation in Antiestrogen Resistance |
MAY 2005 |
18 pages |
| Authors:
Bianca P. Gomez; Robert Clarke; GEORGETOWN UNIV WASHINGTON DC
|
| HXBP-1, a basic leucine zipper protein (bZIP), is a transcription factor that belongs to the activating transcription factor/cAMP response element-binding protein (ATF/CRE) family of transcription factors and can bind to and activate the cyclic AMP response elements (OREs). In our previous studies, serial analysis of gene expression has shown that hXBP-1 may contribute to antiestrogen resistance in human breast cancer cells. In antiestrogen resistant cells ORE-regulated transcription (promoter- reporter assay) ... |
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| Forskolin, an Inducer of Camp, Up-Regulates Acetylcholinesterase Expression and Protects Against Organophosphate Exposure in Neuro 2A Cells |
16 NOV 2004 |
12 pages |
| Authors:
Nabaneeta Pal; Bryan F. Curtin; Jaimee R. Compton; Richard K. Gordon; Madhusodana P. Nambiar; WALTER REED ARMY INST OF RESEARCH SILVER SPRING MD
|
| Bioscavenger prophylactic therapy using purified human acetylcholinesterase (AChE) or butylcholinesterase (BChE) is a promising treatment for future protection against chemical warfare agent (CWA) exposure. However, the potential limitations of this approach has led to our investigation of alternative bioscavenger approaches using Forskolin, an inducer of cyclic AMP (cAMP). The optimal dose found for repeated treatment of Forskolin was 12-24 M. Exposure to the organophosphate diisopropylflurophophate (DFP) showed that Forskolin treatment ... |
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| CRE Activation in Antiestrogen Resistance |
MAY 2004 |
13 pages |
| Authors:
Bianca P. Gomez; Robert Clarke; GEORGETOWN UNIV WASHINGTON DC
|
| HXBP-1, a basic leucine zipper protein (bZIP), is transcription factor that belongs to the activating transcription factor/cAMP response element-binding protein (ATFICRE) family of transcription factors and can bind to and activate the cyclic AMP response elements (CREs). In our previous studies, serial analysis of gene expression has shown that hXBP-1 may contribute to antiestrogen resistance in human breast cancer cells. In antiestrogen resistant cells CRE-regulated transcription (promoter-reporter assay) activity is ... |
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| Phylogeny of Cyclic Nitramine-Degrading Psychrophilic Bacteria in Marine Sediment and Their Potential Role in the Natural Attenuation of Explosives |
2004 |
10 pages |
| Authors:
Jian-Shen Zhao; Jim Spain; Sonia Thiboutot; Guy Ampleman; Charles Greer; Jalal Hawari; NATIONAL RESEARCH COUNCIL OF CANADA OTTAWA (ONTARIO) BIOCHEMISTRY LAB
|
| Previously we reported on in situ mineralization of cyclic nitramine explosives including hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) and octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX) in marine sediment from Halifax Harbour. In the present study, we isolated several novel psychrophilic bacteria from the sediment with optimal growth temperature at 10 or 15 C. Phylogenetic analysis of their 16S rRNA genes identified the isolates as members of the gamma and delta subdivisions of Proteobacteria, Fusobacteria and Clostridiales. The isolates ... |
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| The Synthesis and Characterization of Lubricants Based on POSS technology |
27 SEP 2002 |
33 pages |
| Authors:
Rusty Blanski; Brent Viers; Rene Gonzalez; Andre Lee; Shawn H. Phillips; AIR FORCE RESEARCH LAB EDWARDS AFB CA SPACE AND MISSILE PROPULSION DIV
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| Molecularly Reinforced Polymers |
22 FEB 2002 |
51 pages |
| Authors:
Rusty L. Blanski; Tim Haddad; Brent Viers; Rene Gonzalez; Brian Moore; AIR FORCE RESEARCH LAB EDWARDS AFB CA PROPULSION DIRECTORATE WEST
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| Length-Dependence of Intramolecular Electron Transfer in Sigma-Bonded Rigid Molecular Rods: An ab initio Molecular Orbital Study |
10 JAN 2002 |
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| Authors:
Ranjit Pati; Shashi P. Karna; NEW MEXICO UNIV ALBUQUERQUE
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| The dependence of electron transfer (ET) coupling element, V?sub AB!, on the length of rigid-rod-like systems consisting of bicyclo1.1.1pentane (BCP), cubane (CUB), and bicyclo2.2.2octane (BCO) monomers, has been investigated with the use of ab initio Hartree-Fock (HF) method employing Marcus-Hush two-state (TS) model. The value of V?sub AB! decreases exponentially with increase in the number of the cage units of the sigma-bonded molecules. The calculated decay constant, beta, shows good ... |
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| Retinol Esterification in Human Breast Cancer Cells |
JAN 2002 |
31 pages |
| Authors:
Limin Liu; CORNELL UNIV MEDICAL COLL NEW YORK
|
| This study was designed to identify the RA target genes in the normal human mammary epithelial cells (HMEC) and breast cancer cells. We found that the IL-1Beta gene was an early responsive gene and its expression was up-regulated as early as two hours after RA treatment. Results from the treatment of HMEC with cycloheximide and actinomycin D indicated that the expression of the IL- 1Beta gene was regulated by RA ... |
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| ACS Symposium on Three-Dimensional Silicon-Oxygen Cages |
31 DEC 2001 |
16 pages |
| Authors:
Mark Gordon; IOWA STATE UNIV AMES
|
| The symposium consisted of eight invited speakers plus two contributed talks, over a one day period. The talks included both theory and experiment, leading to an excellent exchange of ideas and possibly leading to new collaborative efforts. |
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| Extending Use of Ion Vapor Deposited (IVD) Aluminum as a Replacement for Electroplated Cadmium |
AUG 2001 |
|
| Authors:
Brian E. Placzankis; John H. Beatty; ARMY RESEARCH LAB ABERDEEN PROVING GROUND MD WEAPONS AND MATERIALS RESEARCH DIRECTORATE
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| Continued environmental pressures have caused the Army and the rest of DoD to reduce their use of hazardous materials and processes. The process of electroplating cadmium usually produces considerable hazardous waste. Further these electroplated items can release cadmium (a heavy metal toxin) back into the environment. As part of a program funded through the SERDP office (the Strategic Environmental Research and Development Program) sacrificial coatings of chromated ion vapor deposited ... |
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| A Potential Therapeutic Role of J Series Prostaglandins in PPAR(gamma) Mediated Treatment of Breast Cancer |
JUN 2001 |
11 pages |
| Authors:
Carl E. Clay; Floyd H. Chilton; Kevin P. High; WAKE FOREST UNIV WINSTON-SALEM NC SCHOOL OF MEDICINE
|
| Cyclopentenone prostaglandin derivatives of arachidonic acid are promising molecules in the fight against cancer, but their mechanism of action is not well understood. Several investigators have shown that the terminal derivative of prostaglandin J2 (PGJ2) metabolism 15deoxy Delta PGJ2 (15dPGJ2) is a potent activator of the nuclear hormone receptor peroxisome proliferator activated receptor gamma (PPAR gamma), but 15dPGJ2 effects can be mediated by PPAR gamma-dependent and PPAR gamma-independent mechanisms. A ... |
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| Mechanisms of Altered Control of Proliferation by Cyclic Amp/Protein Kinase A During Mammary Tumor Progression |
JUN 2001 |
29 pages |
| Authors:
Walter Imagawa; KANSAS CITY UNIV MO
|
| Changes in signal transduction networks occur during mammary tumor progression that affect the proliferative response of the cells to exogenous factors. These alterations may be related to the loss of hormonal regulation of breast cancer which has a major impact on prognosis and therapy of breast cancer. The goal of this research was to identity the mechanisms underlying the difference in the proliferative response to 3'-5' cyclic adenosine monophosphate (cAMP) ... |
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| Fuels Combustion Research: Supercritical Fuel Pyrolysis |
22 JAN 2001 |
41 pages |
| Authors:
Irvin Glassman; PRINCETON UNIV NJ DEPT OF MECHANICAL AND AEROSPACE ENGINEERING
|
| Present and anticipated variation in jet propulsion fuels due to advanced engine compression ratios and airframe cooling requirements necessitate greater understanding of chemical phenomena associated with the feed system and combustion aspects of the airbreathing propulsion systems under consideration by the U. S. Air Force. With AFOSR support an integrated. fundamental research program had been established at Princeton. The focus during the subject period was directed to understanding the pyrolysis ... |
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| Fuels Combustion Research: Supercritical Fuel Pyrolysis |
21 SEP 2000 |
39 pages |
| Authors:
Irvin Glassman; PRINCETON UNIV NJ DEPT OF MECHANICAL AND AEROSPACE ENGINEERING
|
| Present and anticipated variation in jet propulsion fuels due to advanced engine compression ratios and airframe cooling requirements necessitate greater understanding of chemical phenomena associated with the feed system and combustion aspects of the airbreathing propulsion systems under consideration by the U.S. Air Force. With AFOSR support an integrated, fundamental research program had been established at Princeton. The focus during the subject period was directed to ... |
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| Mechanisms of Altered Control of Proliferation by Cyclic Amp/Protein Kinase a During Mammary Tumor Progression |
JUN 2000 |
|
| Authors:
Walter Imagawa; KANSAS UNIV MEDICAL CENTER KANSAS CITY
|
| We hypothesize that alterations in the regulation of growth by cAMP during mammary tumor progression are related to MAP kinase (ERK, JNK, p38) signaling modules known to be affected by cAMP and pertussis toxin (PT)- sensitive G proteins. Mammary epithelial cells from normal mouse mammary glands were compared to ovarian-independent mouse mammary tumors (OIT) in serum-free, collagen gel cell culture. The role of cAMP-pathway responsive transcription factors in PT or ... |
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| Mechjanisms of Altered Control of Proliferation by Cyclic Amp/Protein Kinase a During Mammary Tumor Progression |
JUN 2000 |
19 pages |
| Authors:
Walter Imagawa; KANSAS UNIV MEDICAL CENTER KANSAS CITY
|
| We hypothesize that alterations in the regulation of growth by cAMP during mammary tumor progression are related to MAP kinase (ERK, NC, p38) signaling modules known to be affected by cAMP and pertussis toxin (PT)- sensitive G proteins. Mammary epithelial cells from normal mouse mammary glands were compared to ovarian-independent mouse mammary tumors (OIT) in serum-free, collagen gel cell culture. The role of cAMP-pathway responsive transcription factors in PT or ... |
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| High Performance Electro-Optic Polymeric Material Systems for Device Applications |
01 MAY 2000 |
13 pages |
| Authors:
Alex K-Y Jen; NORTHEASTERN UNIV BOSTON MA DEPT OF CHEMISTRY
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| We have made significant breakthrough in the E-O polymers via the successful development of chromophores and polymer synthesis. A series of highly efficient chemically and thermally stable (>310 deg C) nonlinear optical chromophores were prepared through the replacement of the most reactive CN group in the tricyanovinylthiophene derivatives perfluoroaryl units. In addition we have demonstrated a new and efficient approach for synthesizing novel second- order NLO ... |
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| Combinatorial and Biomimetic Approach on Asymmetric Catalysis for the Synthesis of Ferroelectric Liquid Crystals |
28 FEB 2000 |
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| Authors:
Xumu Zhang; PENNSYLVANIA STATE UNIV UNIVERSITY PARK
|
| During the funding period, we have made significant progress both in the developing new methods for asymmetric synthesis and discovering new liquid crystal materials. Over a dozen of papers have been published or in press in several journals (J. Am. Chem. Soc., J. Org. Chem. and Tetrahedral Letter) and three have been submitted for publication. We have developed a chiral toolbox with a large set ... |
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| AASERT-96 Synthesis and Properties of Polyarylene Vinylenes for LED application |
01 NOV 1999 |
18 pages |
| Authors:
Frank E. Karasz; MASSACHUSETTS UNIV AMHERST DEPT OF POLYMER SCIENCE AND ENGINEERING
|
| Conjugated/non-conjugated alternating block copolymers containing cyano-modified distirylbenzene units as emitting chromophores were synthesized via Knoevenagel and Wittig reactions; the non-conjugated block was an alkylene spacer. The polymers were differentiated with respect to the location of the cyano groups in the chromophoric block (double bond or phenylene ring). When photoluminescence and electroluminescence spectra of these materials were compared with those of a similar structure without ... |
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| New Tetraazacrown Ethers Containing Two Pyridine, Quinoline, 8- Hydroxyquinoline, or 8-Aminoquinoline Sidearms |
12 AUG 1999 |
11 pages |
| Authors:
Zhaoxia Yang; Jerald S. Bradshaw; Xian X. Zhang; Paul B. Savage; Krzysztof E. Krakowiak; BRIGHAM YOUNG UNIV PROVO UT DEPT OF CHEMISTRY AND BIOCHEMISTRY
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| A series of macrocyclic tetraazacrown ethers containing two pyridine, quinoline, 8-hydroxyquinoline, or 8-aminoquinoline sidearms has been prepared. Crab-like cyclization of bis(alpha-chloroacetamide)s and diamines followed by reduction of the cyclic diamides was used to synthesize the selected crown ethers containing two unsubstituted macroring nitrogen atoms. The preparation of the macrocycles with sidearms was accomplished by reductive aminatlon of the proper aldehydes with the crown ethers using sodium triacetoxyborohydride (NaBH(OAc)3) as the ... |
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| Cyclooligomerizations as Possible Routes to Cubane-Like Systems |
08 JUN 1999 |
24 pages |
| Authors:
Peter Politzer; Pat Lane; John J. Wiener; NEW ORLEANS UNIV LA DEPT OF CHEMISTRY
|
| Octanitrocubane and 1,3,5,7-tetranitro-2,4,6,8-tetraazacubane are predicted to be high-performance energetic materials; however neither compound has as yet been synthesized. In principle, they could be prepared by the cyclooligomerizations of dinitroacetylene and nitryl cyanide, respectively. There is some encouraging chemical evidence that this may be feasible. The firststeps in these processes might conceivably be cyclic dimerizations to form tetranitrocyclo-butadiene and 1,3-dinitro-2,4-diazacyclobutadiene. We have used a density functional computational procedure, B3P86/6-31G(**), to analyze ... |
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| Cyclic AMP Modulation of Estrogen-Induced Effects: A Novel Mechanism forHormonal Resistance in Breast Cancer |
JUN 1999 |
211 pages |
| Authors:
Benita S. Katzenellenbogen; ILLINOIS UNIV CHAMPAIGN
|
| This research has been aimed at elucidating why breast cancer cells become resistant to antiestrogen treatment. Antiestrogens are used widely in the treatment of breast cancer, and although almost 50% of breast cancer patients benefit substantially from treatment with tamoxifen, many of these women eventually suffer relapse because some of the breast cancer cells become resistant to tamoxifen. We find that cyclic AMP stimulates the agonist ... |
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| Kinetics of Boron Carbon HEDM |
28 MAY 1999 |
16 pages |
| Authors:
C. W. Larson; AIR FORCE RESEARCH LAB EDWARDS AFB CA SPACE AND MISSILE PROPULSION DIV
|
| The objective of this research is the development and characterization of a boron atom source. |
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| Synthesis of New Tetraazacrown Ethers Capable of Forming Metal Ion Ligating Agents Containing Two Fluoroionophores or Chromoionophores |
08 MAR 1999 |
13 pages |
| Authors:
Z. Yang; J. S. Bradshaw; P. B. Savage; K. E. Krakowiak; N. K. Dalley; BRIGHAM YOUNG UNIV PROVO UT DEPT OF CHEMISTRY
|
| Four tetraazacrown ethers containing two unsubstituted ring nitrogen atoms were prepared via The crab-like cyclization reaction of two diamines with two bis-a-chloroamides followed by reduction of the resulting macrocyclic diamides. Thus, N,N'-dimethyltetraaza-15- crown-5 (12), N,N'-dimethyltetraaza- 16-crown-5 (13), N,N'-dimethyltetraazathia-15-crown-5 (14), and N,N'- dimethyltetraazathia-l6-crown-5 (15) macrocyclic ligands were prepared. X-ray crystal structures were determined for the macrocyclic diamide intermediates leading to 13 and 14. ... |
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| Novel Approaches to the Characterization of Specific Protein-Protein Interactions Important in Gene Expression |
30 OCT 1998 |
7 pages |
| Authors:
Ronald L. Somerville; PURDUE RESEARCH FOUNDATION LAFAYETTE IN DIV OF SPONSORED PROGRAMS
|
| Through the application of a range of techniques in the areas of biochemistry, molecular biology, and microbial physiology, we have purified and characterized the TyrR protein of Haemophilus influenzae. This dimeric protein interacts with specific operator targets associated with promoters that drive the production of proteins essential for aromatic amino acid biosynthesis or transport. Like its E. coli counterpart, the H. influenzae protein is organized into discrete domains that bind ... |
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| Cyclic AMP Modulation of Estrogen-Induced Effects: A Novel Mechanism forHormonal Resistance in Breast Cancer |
OCT 1998 |
154 pages |
| Authors:
Benita S. Katzenellenbogen; ILLINOIS UNIV CHAMPAIGN
|
| This research is aimed at elucidating why breast cancer cells become resistant to antiestrogen treatment Antiestrogens are used widely in the treatment of breast cancer, and although almost 50% of breast cancer patients benefit substantially from treatment with tamoxifen, many of these women eventually suffer relapse because some of the breast cancer cells become resistant to tamoxifen. We find that cyclic AMP stimulates the agonist ... |
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| Computed Heats of Formation |
09 APR 98 |
5 pages |
| Authors:
Peter Politzer; M. E. Grice; Monica C. Concha; Pat Lane; NEW ORLEANS UNIV LA DEPT OF CHEMISTRY
|
| We have computed heats of formation for compounds 1 - 8 (Table 1). The first five are target compounds proposed by M. Trudell (University of New Orleans); 6 - 8 have recently been prepared by R. Schmitt and J. Bottaro (SRI). For the molecular systems 1 - 7, we used our density functional procedure to obtain gas phase heats of formation, which were converted to liquid and solid state values ... |
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| The Dihydronaphthalene Elimination Reaction as a Route to Gallium- Nitrogen Compounds. Crystal and Molecular Structure of (PhMe2CCH2)2GaNHPh2 |
16 MAR 1998 |
25 pages |
| Authors:
O. T. Beachley; Matthew J. Noble; Melvyn R. Churchill; Charles H. Lake; STATE UNIV OF NEW YORK AT BUFFALO DEPT OF CHEMISTRY
|
| The dihydronaphthalene derivative Na2?C10H8Ga(CH2CMe2Ph)2Cl2! reacts at room temperature with NH3, n-PrNH2 and PhNH2 in THF solution to form high yields of (PhMe2CCH2)2GaNHR2 (R = H, n-Pr and Ph), C10H10 and NaCl. In contrast, the elimination reactions between Ga(CH2CMe2Ph)3 with these same amines to form (PhMe2CCH2)2GaNHR2 and PhCMe3 require temperatures of 150 deg C. The cyclopentadiene elimination reaction between (PhMe2CCH2)2Ga(C5H5) and aniline occurs at -10 deg C and is the fastest ... |
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| Low Temperature Reactions for the Preparation of Group 13-15 Materials from Organo-gallium(I) and -indium(I) Compounds |
06 DEC 97 |
15 pages |
| Authors:
O. T. Beachley Jr.; Jeffrey F. Lees; Matthew J. Noble; STATE UNIV OF NEW YORK AT BUFFALO DEPT OF CHEMISTRY
|
| The reactions of pentamethylcyclopentadienylin-dium(I) In(C5Me5) with white phosphorus (P4) at 175 deg C and of neopentylgallium(I) Ga(CH2CMe3)n with P4 at 350- 400 deg C and with NH3 at 460-480 deg C in sealed tubes provide routes to indium phosphide, gallium phosphide and hexagonal gallium nitride, respectively. The formation of these group 13-15 materials as black solids was confirmed by their X-ray photoelectron spectra, X-ray powder diffraction patterns and physical properties. ... |
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| Cyclic AMP Modulation of Estrogen-Induced Effects: A Novel Mechanism for Hormonal Resistance in Breast Cancer |
OCT 1997 |
150 pages |
| Authors:
Benita S. Katzenellenbogen; ILLINOIS UNIV AT URBANA
|
| This research is aimed at elucidating why breast cancer cells become resistant to antiestrogen treatment. Antiestrogens are used Widely in the treatment of breast cancer, and although almost 50% of breast cancer patients benefit substantially from treatment with tamoxifen, many of these women eventually suffer relapse because some of the breast cancer cells become resistant to tamoxifen. We find that cyclic AMP stimulates the agonist activity of tamoxifen-like antiestrogens and ... |
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| Cyclopentadiene Elimination Reaction as a Route to Bis(Neopentyl)Gallium Phosphides, Crystal and Molecular Structures of (Me3CCh2)2GaPEt22 and (Me3CCH2) 2GaP(C6H11)22 |
12 MAY 97 |
30 pages |
| Authors:
O. T. Beachley Jr.; John P. Maloney; Robin D. Rogers; STATE UNIV OF NEW YORK AT BUFFALO DEPT OF CHEMISTRY
|
| A major challenge for synthetic group 13 chemistry is to discover new reactions for the preparation of ultrapure precursors for electronic materials. Thus, the simplest and most direct route which involves the most limited number of synthetic steps from the fewest reagents of high purity at the lowest possible reaction temperature should minimize the introduction of impurities. Consequently, our research has been directed toward the use of the hydrocarbon elimination ... |
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| Energetic Compounds for Use in Shaped-Charge, Follow-Through Devices |
MAR 97 |
29 pages |
| Authors:
Peter A. Wade; John D. Sullivan Jr.; Abe Turetsky; BATTELLE COLUMBUS LABS RESEARCH TRIANGLE PARK NC
|
| Six organic compounds (4,5-dihydro-3-nitroisoxazole, 2,2- dinitropropane, 1,1-dinitroethane, 1,3-dinitropropane, nitrocyclopropane, and trans-1,2-dinitrocyclopropane) were prepared for detonation testing. Sensitized nitromethane solutions of these compounds were detonated using plastic blocks to observe blast power. The volume of the crater in the observation block was measured: the larger the crater, the more powerful the detonation. A statistical treatment of the results was performed, 1,1 -Dinitroethane and trans-1, 2- dinitrocyclopropane gave the most promising results. ... |
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| Energetic Compounds for Use in Shaped-Charge, Follow-Through Devices |
MAR 97 |
29 pages |
| Authors:
John D. Sullivan Jr.; Abe Turetsky; EDGEWOOD RESEARCH DEVELOPMENT AND ENGINEERING CENTER ABERDEEN PROVING GROUND MD
|
| Six organic compounds (4,5-dihydro-3-nitroisoxazole, 2,2- dinitropropane, 1,1-dinitroethane, 1-3-dinitropropane, nitrocyclopropane, and trans-1,2-dinitrocyclopropane) were prepared for detonation testing. Sensitized nitromethane solutions of these compounds were detonated using plastic blocks to observe blast power. The volume of the crater in the observation block was measured: the larger the crater, the more powerful the detonation. A statistical treatment of the results was performed. 1,1-Dinitroethane and trans-1, 2- dinitrocyclopropane gave the most promising results. 1,3-Dinitropropane ... |
|
| Photochemistry of Fe2(CO)8(mu-CH2) |
DEC 96 |
73 pages |
| Authors:
Daniel M. Branan; AIR FORCE INST OF TECH WRIGHT-PATTERSON AFB OH
|
| We herein present the previously unreported photochemistry of two forms of the dimetallocyclopropane complex Fe2(CO)8(mu-CH2), and its deuterated analog. We have determined that it behaves similarly to other dimetallic carbonyls in that it eliminates carbon monoxide upon irradiation with high- intensity UV/visible light to form distinct single and double CO-loss products. Upon formation of a 34-electron single CO-loss product, however, it exhibits the ability to either maintain an unbalanced 16/18-electron ... |
|
| Cyclic AMP Modulation of Estrogen-Induced Effects: A Novel Mechanism for Hormonal Resistance in Breast Cancer |
OCT 96 |
106 pages |
| Authors:
Benita S. Katzenellenbogen; ILLINOIS UNIV AT URBANA
|
| This research is aimed at elucidating why breast cancer cells become resistant to antiestrogen treatment. Antiestrogens are used widely in the treatment of breast cancer, but development of resistance and patient relapse is a significant problem. The antiestrogen tamoxifen is the most widely prescribed drug for breast cancer treatment and it is usually considered the treatment of choice for the endocrine therapy of breast cancer because of its effectiveness, ease ... |
|
| Breast Cancer and Estrogen Biosynthesis in Adipose Tissue |
OCT 96 |
46 pages |
| Authors:
Serdar E. Bulun; TEXAS UNIV AT DALLAS
|
| The long-range goal of this Application was to characterize the regulation of aromatase expression in the breast bearing a tumor. It included four specific aims: to quantify adipose tissue P450arom transcript levels in a large number of mastectomy specimens at various distances from the tumor; to determine alternative promoters that are used for aromatase expression in adipose samples proximal to a tumor; to characterize novel 5'-ends of P450arom transcripts in ... |
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| Study of Small Ligands Which Bind Specifically to Breast Cancer |
SEP 1996 |
|
| Authors:
David N. Krag; VERMONT UNIV BURLINGTON
|
| The goal of this work is to identify small ligands to ErbB2 which may be used to specifically target breast cancer cells. Using large libraries of peptides displayed by phage, we have identified several candidate peptides which may bind to ErbB2, including recent elucidation of a peptide which may bind specifically to the surface of live cells overexpressing ErbB2. We now have ErbB2 ECD purified more than a million-fold and ... |
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| The Binding of Oligopeptides to Cyclodextrins: The Role of the Tyrosine Group |
AUG 96 |
34 pages |
| Authors:
E. J. Bekos; J. A. Gardella Jr.; F. V. Bright; STATE UNIV OF NEW YORK AT BUFFALO DEPT OF CHEMISTRY
|
| The formation of alpha-cyclodextrin (alpha-CD) and beta-cyclodextrin (beta-CD) inclusion complexes with free tyrosine and the tyrosine residues in two oligopeptides were investigated using steady-state fluorescence spectroscopy. The oligopeptides consist of five amino acids (pentapeptide) and the tyrosine residues are at the n-terminus of both peptides. The two peptides used in this study have specific biological applications and are known to bind selectively to specific receptors. Cyclodextrins were used to model ... |
|
| Functions of Wild-Type and Mutant Forms of p53 in Breast Cancer |
AUG 96 |
51 pages |
| Authors:
Sheau-Yannn Shieh; Xinbin Chen; COLUMBIA UNIV NEW YORK
|
| It is well established that induction of the p53 tumor suppressor protein in cells can lead to either cell cycle arrest or apoptosis. To further understand features of p53 that contribute to these cell responses several p53- null Saos2 and H1299 cell lines were generated that express wild-type or mutant forms of p53, or the cyclin-dependent kinase inhibitor p21, under a tetracycline regulated promoter. Our results show that while the ... |
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| Room Temperature Cyclopentadiene Elimination Reaction for the Synthesis of Diethylgallium-Amides, -Phosphides and -Thiolates, Crystal and Molecular Structures of Et2GaP(t-Bu)22 and Et2GaS(SiPh3)2 |
24 JUN 96 |
25 pages |
| Authors:
O. T. Beachley Jr.; Daniel B. Rosenblum; Melvyn R. Churchill; Charles H. Lake; Laurence M. Toomey; STATE UNIV OF NEW YORK AT BUFFALO DEPT OF CHEMISTRY
|
| The compounds Et2GaNEt22, Et2GaN(H)(Me)2, Et2GaN(H)(t-Bu)2, Et2GaP(i- Pr)22, Et2GaP(t-Bu)22, and Et2GaS(SiPh3)2 have been prepared in high yields at room temperature by the elimination of cyclopentadiene from Et2Ga(C5H5) and the corresponding amine, phosphine or thiol. The three diethylgallium amides and Et2GaP(i-Pr)22 are liquids whereas the other phosphide and the thiolate are crystalline solids at room temperature. All compounds were fully characterized by elemental analyses, (1)H and (31)P NMR spectroscopy and cryoscopic molecular ... |
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| Some Computationally-Predicted Properties of a Group of Proposed Energetic Compounds |
JUN 96 |
6 pages |
| Authors:
Peter Politzer; Pat Lane; M. E. Grice; NEW ORLEANS UNIV LA DEPT OF CHEMISTRY
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| We have carried out computational analyses and predictions of certain properties for a group of proposed energetic target compounds. The properties reported are: Heat of formation, 298 K, gaseous; heat of sublimation, 298 K; heat of formation, 298 K, solid; heat of fusion at melting point; heat of vaporization at boiling point; density, liquid; boiling point; impact sensitivity. Of the molecules considered, 1,3,5,7-tetranitro-2,4,6,8- tetraazacubane is particularly promising as a potential ... |
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| Potential Hazards in the Handling of Aged AC and CK Munitions |
JUN 96 |
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| Authors:
Herbert S. Aaron; Luke A. Burke; James O. Jensen; Pallassana N. Krishnan; C. P. Vlahacos; EDGEWOOD RESEARCH DEVELOPMENT AND ENGINEERING CENTER ABERDEEN PROVING GROUND MD
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| Due to evidence that there are potential hazards in handling containers of chemical agents CK (ClCN) and AC (HCN), we present a literature survey of reactions of these agents in monomer and solid polymeric form. Additionally, we present results of theoretical and experimental studies on exothermic polymerization reactions. The results show that the solid form of the cyclic trimers of these agents are not shock sensitive. Additionally, the results estimate ... |
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| Synthesis of Novel Tetrametallic and Trimetallic Compounds from Reactions of MMe3(M=Al,Ga) with 1,2-(H2E)2C6H4(E=N,P) |
21 MAY 96 |
32 pages |
| Authors:
Richard L. Wells; Hamid Rahbarnoohi; Paul B. Glaser; Louise M. Liable-Sands; Arnold L. Rheingold; DUKE UNIV DURHAM NC DEPT OF CHEMISTRY
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| The independent 2:1 reactions of MMe3 (M = Al, Ga) with 1,2-(H2P) 2C6H4 resulted in the formation of the novel 8-membered tetrametallic ring compounds with the general formula ((Me2M)4((mu- PH)2(C6H4))2) (M = Al (1), Ga (2)) in a nearly quantitative yield. Combining AlMe3 and 1,2-(H2P)2C6H4 in a 1:1 ratio also afforded 1. The reaction of AlMe3 with 1,2-(H2N)2C6H4 (2:1) yielded the novel asymmetric compound ((Me2Al)2AlMe(C6H4(NH)2)2)-AlMe3 (3). Compound 3 is composed ... |
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| Air Force High Energy Density Material (HEDM) Project |
31 MAR 96 |
26 pages |
| Authors:
Rodney J. Bartlett; FLORIDA UNIV GAINESVILLE
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| This report summarizes the successes of our effort for the HEDM program, both methodological and in terms of metastable molecule chemistry. Recognizing the prospects for highly energetic metastable species based upon nitrogen, we initiated our study of a variety of such potential molecules. These included N3H3, which is isoelectronic with the well-known species ozone, cyclopropane and propene; tetrahedral N4 which is isovalent with P4 or As4, and is forbidden by ... |
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| Small-Molecule Phosphazene-Substituted Phenoxy Side Groups Synthesis, X- Ray Structures, and Comparisons with the Corresponding High Polymers |
19 FEB 96 |
81 pages |
| Authors:
Harry R. Allcock; Saman Al-Shali; Dennis C. Ngo; Karyn B. Vissher; Masood Parvez; PENNSYLVANIA STATE UNIV UNIVERSITY PARK DEPT OF CHEMISTRY
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| A series of new cyclic phosphazenes and a linear short chain phosphazene have been synthesized as models for the preparation of the corresponding high polymers. Several of the high polymers were also prepared. The small-molecule compounds were characterized by a combination of (31)P NMR, mass spectrometry, and elemental analysis. The crystal and molecular structures of hexakis(4-methylphenoxy)cyclotriphosphazene, hexakis(4-hydroxyphenoxy) cyclotriphosphazene, hexakis(4-benzyl- oxyphenoxy)cyclotriphosphazene, octakis(4-phenoxyphenoxy)cyclotetraphosphazene, and (t-butylphenoxy)diphosphorus were investigated by single crystal X-ray diffraction ... |
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| Synthesis and Structural Characterization of Alkyl, Gallium-Phosphorus Compounds, X-Ray Crystal Structures of (Me3CCH2)2(Cl)Ga.P(SiMe3)3, R2GaP(SiMe3) 2GaR2Cl(R=Me3CCH2 and Me3SiCH2), and ((R)(X)GaP(SiMe3)2)2 (R=Me3CCH2, X=Cl; R=Me3CCH2, X=Me3CCH2; R=Me3S |
20 DEC 95 |
35 pages |
| Authors:
Richard L. Wells; Ryan A. Balwin; Peter S. White; William T. Pennington; Arnold L. Rheingold; DUKE UNIV DURHAM NC DEPT OF CHEMISTRY
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| Continued activity in the development of single-source precursors to 13-15 semiconductor materials has motivated our laboratory to investigate the synthesis of novel organogallium phosphorus compounds which might serve as potential precursors to GaP. Recently, our efforts to produce the gallium- phosphorus bond have led to the formation of interesting ring compounds and simple adducts. |
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