| Polyfibroblast: A Self-Healing and Galvanic Protection Additive |
26 Dec 2012 |
6 pages |
| Authors:
Jason J Benkoski; JOHNS HOPKINS UNIV LAUREL MD APPLIED PHYSICS LAB
|
 | The goal of this project is to develop a primer additive that mimics the self-healing ability of skin by forming a polymer scar across scratches. Designed to work with existing military grade primers, Polyfibroblast consists of microscopic, hollow zinc tubes filled with a moisture-cured polyurethane-urea (MCPU). When scratched, the foaming action of a propellant ejects the resin from the broken tubes and completely fills the crack. No catalysts or curing ... |
|
| Polyfibroblast: A Self-Healing and Galvanic Protection Additive |
26 Nov 2012 |
5 pages |
| Authors:
Jason J Benkoski; JOHNS HOPKINS UNIV LAUREL MD APPLIED PHYSICS LAB
|
| The goal of this project is to develop a primer additive that mimics the self-healing ability of skin by forming a polymer scar across scratches. Designed to work with existing military grade primers, Polyfibroblast consists of microscopic, hollow zinc tubes filled with a moisture-cured polyurethane-urea (MCPU). When scratched, the foaming action of a propellant ejects the resin from the broken tubes and completely fills the crack. No catalysts or curing ... |
|
| Viral Oncolytic Therapeutics for Neoplastic Meningitis |
Jul 2012 |
7 pages |
| Authors:
Kumudu D Kuruppu; MASSACHUSETTS GENERAL HOSPITAL BOSTON
|
| Neoplastic meningitis is a severe complication of breast cancer for which there is no curative treatment at present. The project aims to develop a novel, safe and efficient therapy for neoplastic meningitis HSV-1 oncolysis therapy. For the first year of the award period we have propagated the HSV-1 replication conditional mutant (hrR3) with burst assays and generated three different virus preparations to establish viral titers of 1x10(7), 1x10(8) and 1x10(9) ... |
|
| Polymer Claw: Instant Underwater Adhesive |
24 Apr 2012 |
8 pages |
| Authors:
Jason J Benkoski; JOHNS HOPKINS UNIV LAUREL MD APPLIED PHYSICS LAB
|
| The goal of this project is to develop a primer additive that mimics the self-healing ability of skin by forming a polymer scar across scratches. Designed to work with existing military grade primers. Polyfibroblast consists of microscopic, hollow zinc tubes filled with a moisture-cured polyurethane-urea (MCPU). When scratched, the foaming action of a propellant ejects the resin from the broken tubes and completely fills the crack. No catalysts or curing ... |
|
| Polyfibroblast: A Self-Healing and Galvanic Protection Additive |
23 Mar 2012 |
9 pages |
| Authors:
Jason J Benkowski; JOHNS HOPKINS UNIV LAUREL MD APPLIED PHYSICS LAB
|
| The goal of this project is to develop a primer additive that mimics the self-healing ability of skin by forming a polymer scar across scratches. Designed to work with existing military grade primers, Polyfibroblast consists of microscopic, hollow zinc tubes filled with a moisture-cured polyurethane-urea (MCPU). When scratched, the foaming action of a propellant ejects the resin from the broken tubes and completely fills the crack. No catalysts or curing ... |
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| Polyfibroblast: A Self-Healing and Galvanic Protection Additive |
27 Feb 2012 |
8 pages |
| Authors:
Jason J Benkoski; JOHNS HOPKINS UNIV ARLINGTON VA APPLIED PHYSICS LAB
|
| The goal of this project is to develop a primer additive that mimics the self-healing ability of skin by forming a polymer scar across scratches. Designed to work with existing military grade primers, Polyfibroblast consists of microscopic, hollow zinc tubes filled with a moisture-cured polyurethane-urea (MCPU). When scratched, the foaming action of a propellant ejects the resin from the broken tubes and completely fills the crack. No catalysts or curing ... |
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| Automated Discovery of Long Intergenic RNAs Associated with Breast Cancer Progression |
Feb 2012 |
19 pages |
| Authors:
Matthew Iyer; MICHIGAN UNIV ANN ARBOR
|
| Of the 40,000 women in the United States that die from breast cancer every year, almost half of them might have once thought they were cured. While treatment of early stage breast cancer can be curative, up to 30% of node-negative and 70% of nodepositive breast cancers will relapse. Therefore, risk stratification and surveillance of breast cancer is of paramount importance. Prognostic markers such as estrogen and progesterone receptor, ERBB2, ... |
|
| Polyfibroblast: A Self-Healing and Galvanic Protection Additive |
30 Dec 2011 |
5 pages |
| Authors:
Jason J Benkoski; JOHNS HOPKINS UNIV ARLINGTON VA APPLIED PHYSICS LAB
|
| The goal of this project is to develop a primer additive that mimics the self-healing ability of skin by forming a polymer scar across scratches. Designed to work with existing military grade primers, Polyfibroblast consists of microscopic, hollow zinc tubes filled with a moisture-cured polyurethane-urea (MCPU) . When scratched, the foaming action of a propellant ejects the resin from the broken tubes and completely fills the crack. No catalysts or ... |
|
| Polyfibroblast: A Self-Healing and Galvanic Protection Additive |
25 Aug 2011 |
16 pages |
| Authors:
Jason J Benkoski; JOHNS HOPKINS UNIV LAUREL MD APPLIED PHYSICS LAB
|
| The goal of this project is to develop a primer additive that mimics the self-healing ability of skin by forming a polymer scar across scratches. Designed to work with existing military grade primers, Polyfibroblast consists of microscopic, hollow zinc tubes filled with a moisture-cured polyurethane-urea (MCPU). When scratched, the foaming action of a propellant ejects the resin from the broken tubes and completely fills the crack. No catalysts or curing ... |
|
| Polyfibroblast: A Self-Healing and Galvanic Protection Additive |
25 JUL 2011 |
7 pages |
| Authors:
Jason J. Benkoski; MILTON S EISENHOWER RESEARCH CENTER LAUREL MD
|
| The goal of this project is to develop a primer additive that mimics the self-healing ability of skin by forming a polymer scar across scratches. Designed to work with existing military grade primers, Polyfibroblast consists of microscopic, hollow zinc tubes filled with a moisture-cured polyurethane-urea (MCPU). When scratched, the foaming action of a propellant ejects the resin from the broken tubes and completely fills the crack. No catalysts or curing ... |
|
| Polyfibroblast: A Self-Healing and Galvanic Protection Additive |
27 JUN 2011 |
9 pages |
| Authors:
Jason J. Benkoski; JOHNS HOPKINS UNIV LAUREL MD APPLIED PHYSICS LAB
|
| The goal of this project is to develop a primer additive that mimics the self-healing ability of skin by forming a polymer scar across scratches. Designed to work with existing military grade primers. Polyfibroblast consists of microscopic, hollow zinc tubes filled with a moisture-cured polyurethane-urea (MCPU). When scratched, the foaming action of a propellant ejects the resin from the broken tubes and completely fills the crack. No catalysts or curing ... |
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| Novel Antimicrotubule Agents for Breast Cancer |
OCT 2010 |
11 pages |
| Authors:
Sucharita Mistry; MOUNT SINAI SCHOOL OF MEDICINE NEW YORK
|
| Breast cancer is one of the most frequent malignancies and is the major leading cause of cancer-related deaths in women in the U.S. When local therapies for breast cancer fail and the disease progresses, systemic estrogen ablation therapy, with or without chemotherapy, can lead to tumor regression. However, the disease inevitably progresses to an estrogen-independent state that becomes resistant to hormonal therapy and chemotherapy. In this advanced stage, there are ... |
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| Targeting Prostate Cancer for Gene Therapy Utilizing Lentivirus and Oncolytic VSV Virus |
Apr-2009 |
23 pages |
| Authors:
Maryam Moussavi; BRITISH COLUMBIA UNIV VANCOUVER
|
| Prostate cancer is the most commonly diagnosed non-skin carcinoma, and one of the leading causes of cancerrelated deaths in North American men. Presently there are no curative therapies available for advanced metastatic prostate cancer. Oncolytic viral therapy provides an opportunity to efficiently kill primary and metastatic cancer cells while sparing normal cells. Vesicular Stomatitis Virus (VSV) is an oncolytic virus which is able to replicate in cells with a defective ... |
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| Identification of Novel Genes and Candidate Targets in CML Stem Cells |
Jan-2009 |
32 pages |
| Authors:
Connie Eaves; Yun Zhao; BRITISH COLUMBIA CANCER AGENCY VANCOUVER
|
| Chronic myeloid leukemia (CML) is believed to originate from a normal hematopoietc stem cell acquiring the BCR-ABL fusion gene whose protein product has hyperactive tyrosine kinase activity. Though imatinib mesylate(IM) that targets BCR-ABL kinase activity is now widely used, its curative potential as a single agent is not sure, moreover it is unlikely to eliminate the CML stem cells either, which highlights the necessity to elucidate the molecular mechanism operative ... |
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| Mechanical Properties of EPON 826/DEA Epoxy |
26-Jul-2008 |
|
| Authors:
Jennifer L Jordan; Jason R Foley; Clive R Siviour; AIR FORCE RESEARCH LAB EGLIN AFB FL MUNITIONS DIRECTORATE
|
 | Polymers are becoming increasingly used in aerospace structural applications, where they experience complex, non-static loads. Correspondingly, the mechanical properties at high strain rates are of increasing importance in these applications. This paper investigates the compressive properties of Epon 826 epoxy resin cured with diethynolamine (DEA) across strain rates from 10(-3) to 10(4) s(-1). Specimens were tested using an Instron mechanical testing machine for static loading, traditional split Hopkinson pressure bars ... |
|
| Inhibition of Rac GTPases in the Therapy of Chronic Myelogenous Leukemia |
01-Apr-2008 |
77 pages |
| Authors:
CHILDREN'S HOSPITAL MEDICAL CENTER CINCINNATI OH
|
| Chronic myelogenous leukemia (CML) is a clonal myeloproliferative disease (MPD) characterized by the expression of the p210-BCR/ABL fusion gene [1]. This gene is produced by the reciprocal translocation (9; 22) (q34; q11) that juxtaposes the 3 end of Abelson leukemia virus (ABL) gene with the 5 end of the breakpoint cluster region (Bcr) gene on chromosome 22. The transcript formed as a result encodes for the BCR/ABL fusion protein with ... |
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| A BCR-ABL Kinase Activity-Independent Signaling Pathway in Chronic Myelogenous Leukemia |
FEB 2008 |
35 pages |
| Authors:
Shaoguang Li; BURDICK AND JACKSON LABS INC MUSKEGON MI
|
| The BCR-ABL tyrosine kinase inhibitor imatinib mesylate (Gleevec) is the preferred treatment for human chronic myeloid leukemia (CML) but does not cure mice with BCR-ABL-induced acute lymphoblastic leukemia (ALL) similar to CML lymphoid blast crisis. The inability of imatinib to cure CML in mice leads us to hypothesize that a BCR-ABL kinase activity-independent pathway also plays a critical role in the development of this disease. We identified Src kinases as ... |
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| Long-Term Outcomes of Alternative Brachytherapy Techniques for Early Prostate Cancer |
JAN 2008 |
17 pages |
| Authors:
James A. Talcott; MASSACHUSETTS GENERAL HOSPITAL BOSTON
|
| All active, potentially curative treatments for clinically localized prostate cancer damage quality of life. Brachytherapy, or radioactive seed implants, theoretically may increase the target radiation dose and thus improve control of cancer. It has been rapidly adopted in the U.S. despite limited long-term published outcomes, in part because of its convenience and apparently attractive toxicity profile. However, our recent survey of brachytherapy patients after longer follow-up found surprisingly frequent urinary ... |
|
| A BCR-ABL Kinase Activity-Independent Signaling Pathway in Chronic Myelogenous Leukemia |
FEB 2007 |
14 pages |
| Authors:
Shaoguang Li; JACKSON LAB BAR HARBOR ME
|
| The BCR-ABL tyrosine kinase inhibitor imatinib mesylate (Gleevec) is the preferred treatment for human chronic myeloid leukemia (CML), but does not cure mice with BCR-ABL-induced acute lymphoblastic leukemia (ALL), similar to CML lymphoid blast crisis. The inability of imatinib to cure CML in mice leads us to hypothesize that a BCR-ABL kinase activity-independent pathway also plays a critical role in the development of this disease. We identified Src kinases as ... |
|
| Long-Term Outcomes of Alternative Brachytherapy Techniques for Early Prostate Cancer |
JAN 2007 |
18 pages |
| Authors:
James A. Talcott; MASSACHUSETTS GENERAL HOSPITAL BOSTON WELLMAN LABS OF PHOTOMEDICINE
|
| All active, potentially curative treatments for clinically localized prostate cancer damage quality of life. Brachytherapy,or radioactive seed implants, theoretically may increase the target radiation dose and thus improve control of cancer. has been rapidly adopted in the U.S. despite limited long-term published outcomes, in part because of its convenience apparently attractive toxicity profile. However, our recent survey of brachytherapy patients after longer follow-up surprisingly frequent urinary incontinence and erectile dysfunction. ... |
|
| Thermodynamic and Mechanical Properties of Epon 862 With Curing Agent Detda by Molecular Simulation |
DEC 2006 |
40 pages |
| Authors:
Jeremy L. Tack; TEXAS A AND M UNIV COLLEGE STATION DEPT OF CHEMICAL ENGINEERING
|
| Fully atomistic molecular dynamics (MD) simulations were used to predict the properties of EPON 862 cross-linked with curing agent DETDA, a potentially useful epoxy resin for future applications of nanocomposites. The properties of interest were density (at near-ambient pressure and temperature), glass transition temperature, bulk modulus, and shear modulus. The EPON molecular topology, degree of curing, and MD force-field were investigated as variables. The range of molecular weights explored was ... |
|
| Human Prostate Cancer Infiltrating Lymphocytes: Raft Microdomains, Signaling and Activation in Organ Cultures |
JUN 2006 |
37 pages |
| Authors:
Antonella Viola; INSTITUTO VENETO DI MEDICINA MOLECOLARE PADOVA (ITALY)
|
| Prostate cancer is the second leading cause of malignancy-related mortality in males in the Western world. While radical prostatectomy and local radiotherapy are largely successful for patients with localized cancer, available treatments for metastatic prostate carcinoma have demonstrated weak curative efficacy. Thus, androgen reduction often results in the selection of hormone-resistant clones, which seem to be also resistant to radiotherapy or chemotherapy. It is therefore necessary to find alternative therapeutic ... |
|
| Long-Term Outcomes of Alternative Brachytherapy Techniques for Early Prostate Cancer |
JAN 2006 |
16 pages |
| Authors:
James A. Talcott; MASSACHUSETTS GENERAL HOSPITAL BOSTON
|
| All active, potentially curative treatments for clinically localized prostate cancer damage quality of life. Brachytherapy,or radioactive seed implants, theoretically may increase the target radiation dose and thus improve control of cancer. has been rapidly adopted in the U.S. despite limited long-term published outcomes, in part because of its convenience apparently attractive toxicity profile. However, our recent survey of brachytherapy patients after longer follow-up surprisingly frequent urinary incontinence and erectile dysfunction. ... |
|
| Immunomodulation of Hyperthermia for Recurrent Prostate Cancer |
MAR 2005 |
10 pages |
| Authors:
Chandan Guha; MONTEFIORE MEDICAL CENTER BRONX NY
|
| Currently, there is no curative treatment for recurrent prostate cancer (PC). Although, radiation therapy (RT) has been successful in the treatment of primary PC, it is not used to treat locally recurrent PC because of the high morbidity of pelvic reirradiation. Hyperthermia has undergone extensive study as a treatment for BPH and its safety is very well established. Our long-term goal is to develop hyperthermia as a tumoricidal therapy for ... |
|
| Lipoxygenase, Angiogenicity, and Prostate Cancer Radioresistance |
JAN 2005 |
10 pages |
| Authors:
Dao-tai Nie; WAYNE STATE UNIV DETROIT MI
|
| Prostate cancer (PCa) is one of most common cancers affecting American men. Radiotherapy is a prevalent modality for the treatment of prostate tumor. Although radiation is capable of eradicating localized prostate tumors, nearly 30% of patients treated with potentially curative doses relapse at the sites of irradiation. Therefore, there is an imperative need to improve the success rate of radiotherapy for PCa. This proposal is focused on a role of ... |
|
| Mammaglobin and Lipophilin Related Molecules in Normal and Tumor Human Breast Tissue: Expression Hormone Regulation and Functional Analysis |
AUG 2004 |
146 pages |
| Authors:
Etienne R. Leygue; MANITOBA UNIV WINNIPEG
|
| Genes, expression of which is breast specific or is altered during breast tumorigenesis, represent potential targets for new preventive and curative strategies. Such genes, Mammaglobin (MGB1), hSBEM (Human Small Breast Epithelial Mucin), Psoriasin, Estrogen receptor beta (hERB) and SRA (Steroid receptor RNA activator), have been studied during the time of this Award (July 2OO1-July 2004). We found that: MGB1 expression correlates with ER (an established breast cancer prognostic and predictive ... |
|
| A Potent Oncolytic Herpes Simplex Virus for the Therapy of Advanced Prostate Cancer |
JUL 2004 |
15 pages |
| Authors:
Xiaoliu Zhang; BAYLOR COLL OF MEDICINE HOUSTON TX
|
| Although conventional radiation therapy and surgery are potentially curative treatments for organ-confined prostate cancer, there are few effective treatments for metastatic disease. We recently created a potent antitumor agent - the fusogenic oncolytic herpes simplex virus (HSV). The first task originally planned for the first year of this project was to demonstrate the potency of the fusogenic oncolytic HSV against advanced prostate cancer. The subtasks include: a) Production of high ... |
|
| Viscoelastic Properties of Alkoxy Silane-Epoxy Interpenetrating Networks |
NOV 2003 |
40 pages |
| Authors:
Robert E. Jensen; Steven H. McKnight; Giuseppe R. Palmese; ARMY RESEARCH LAB ABERDEEN PROVING GROUND MD
|
| A model epoxy-silane interpenetrating network (IPN) was synthesized to simulate the molecular structure found at the fiber-matrix interphase. The Young's modulus (E) of the epoxy-silane IPN was determined% trough micromechanical analysis both quasi-statically and in the frequency domain. The epoxy-silane IPN was synthesized by diffusion of uncured diglycidyl ether of bisphenol A (DGEBA) epoxy resin and bis (p-aminocyclohexyl) methane (PACM) curing agent into spherical particles of condensed and crosslinked 3- ... |
|
| NUWC XP-1 Polyurethane-Urea: A New, Acoustically Transparent Encapsulant for Underwater Transducers and Hydrophones |
01-Sep-2003 |
5 pages |
| Authors:
Thomas Ramotowski; Kirk Jenne; NAVAL UNDERSEA WARFARE CENTER DIV NEWPORT RI
|
| Almost all acoustic projectors and hydrophones are encapsulated in polymeric materials. These coatings protect the underlying sensors and electronics from physical damage and water ingression, while allowing the passage of acoustical energy without significant reflection, loss, or distortion. Critical material parameters for superior acoustical performance include: (1) density and sound speeds close to those of seawater; (2) low mechanical loss tangent; (3) medium to high shear loss tangent; (4) low ... |
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| Induced Expression of Androgen Receptor in Androgen Independent Prostate Cancer Cells Using an IkBalpha Super Repressor |
SEP 2003 |
23 pages |
| Authors:
Linda M. Kalikin; Kenneth J. Pienta; MICHIGAN UNIV ANN ARBOR
|
| Advanced prostate cancer continues to kill 29,000 men annually in the United States. Despite strides in obtaining extended remissions through the use of hormones and chemotherapeutic agents, there is still no curative therapy for this devastating disease. While most prostate cancers are responsive to androgens and while androgen withdrawal is the main form of treatment, the failure of primary hormone therapy is attributed to androgen-independent tumor expansion. Mechanisms for the ... |
|
| Strategic Manipulation of Tumor Antigens to Enhance Immunogenicity |
SEP 2002 |
26 pages |
| Authors:
Allan D. Hess; JOHNS HOPKINS UNIV BALTIMORE MD SCHOOLOF MEDICINE
|
| Breast cancer is an increasingly common malignancy representing 30% of all cancers in women. Conventional systemic chemotherapy or high dose chemotherapy with autologous stem cell rescue can induce remissions in a significant number of patients, complete curative responses, however, are uncommon. Nearly all patients die of progressive disease within 3 years. Tumor recurrence and progression are thought to be due to the persistence of chemotherapy-resistant tumor cells. Therefore, strategies that ... |
|
| Fire-Resistant Cyanate Ester-Epoxy Blends |
MAY 2002 |
20 pages |
| Authors:
Richard N. Walters; GALAXY SCIENTIFIC CORP EGG HARBOR TOWNSHIP NJ
|
| The cure chemistry, thermal stability, and fire behavior in a series of fire-resistant cyanate ester-epoxy blends were examined. The dicyanate and diepoxide of 1,1-dichloro-2,2-bis(4-hydroxyphenyl)ethylene (bisphenol-C, BPC) were combined in various molar ratios, and the reaction chemistry was monitored using Fourier Transform Infrared Spectroscopy (FTIR) and differential scanning calorimetry (DSC). Fire behavior of the BPC cyanate-epoxy blends was studied in flaming and nonflaming combustion, using fire calorimetry and pyrolysis- combustion flow ... |
|
| Self-Decontaminating Materials |
01 NOV 2001 |
11 pages |
| Authors:
Joseph D. Wander; AIR FORCE RESEARCH LAB TYNDALL AFB FL MATERIALS AND MANUFACTURING DIRECTORATE
|
| Surfaces that resist contamination through some combination of exclusion or reactivity may be grouped as Self-Decontaminating Materials (SDMs). A direct means to effect exclusion is to incorporate fluorine substituents into the surface of the SDM. Reactivity derives from the presence of chemically active groups, either at the surface or distributed throughout the medium. Whereas exclusion and catalytic reactivity tend to persist in the SDM after they have achieved their protective ... |
|
| Processing, Dynamic Studies and Properties of Exfoliated Aerospace Epoxy-Organoclay Nanocomposites |
NOV 2001 |
6 pages |
| Authors:
Chenggang Chen; David Curliss; AIR FORCE RESEARCH LAB WRIGHT-PATTERSON AFB OH MATERIALS AND MANUFACTURING DIRECTORATE
|
| Epoxy nanocomposites were prepared from the montmorillonite after organic treatment with a high T(sub g) epoxy resin (Shell Epon 862 and curing agent W). Investigation of the theological characteristics showed that the addition of clay to the resin did not significantly alter the viscosity or cure kinetics and that the modified resin would still be suitable for liquid composite molding techniques such as resin transfer molding. DSC was performed to ... |
|
| Electron-Beam (E-Beam) Processing as a Means of Achieving High Performance Composite Structures |
NOV 2001 |
80 pages |
| Authors:
James M. Sands; Steven H. McKnight; Bruce K. Fink; Anna Yen; Giuseppe R. Palmese; ARMY RESEARCH LAB ABERDEEN PROVING GROUND MD WEAPONS AND MATERIALS RESEARCH DIRECTORATE
|
| Electron-beam (E-beam) curing is among the key out-of-autoclave technologies being explored for future advanced composite and adhesive applications. E-beam irradiation curing is capable of rapid and through- thickness curing of composite samples up to 2-in thickness, eliminating the need for long cure cycles in the autoclave. However, current resin and adhesive chemistries are optimized for cure by thermal initiation, which involves slow ramps and long cure cycles, particularly for thermoset ... |
|
| Prostate Cancer Treatment Based on the Suppression of Angiogenesis and Metastasis |
JAN 2000 |
|
| Authors:
Renate Pasqualini; BURNHAM INST LA JOLLA CA
|
| Although curative treatments are available for organ-confined prostate cancer, the metastatic spread to organs such as the lymph nodes and bone results in an incurable disease, despite the effectiveness of initial hormone therapy. We have developed a polymer made from the cell adhesion protein fibronectin (termed superfibronectin, sFN). We have previously reported that sFN has anti-metastatic effects against multiple tumor types, including human prostate cancer. We ... |
|
| Fiber-Reinforced Phthalonitrile Composite Cured with Low-Reactivity Aromatic Amine Curing Agent |
14 DEC 1999 |
|
| Authors:
Satya B. Sastri; Teddy M. Keller; DEPARTMENT OF THE NAVY WASHINGTON DC
|
| A fiber-reinforced phthalonitrile composite is made by impregnating or coating a fibrous material with a phthalonitrile prepolymer mixture containing a phthalonitrile monomer and an aromatic amine curing agent that is thermally stable and nonvolatile at a temperature up to about 375 deg C., and that contains at least one electron withdrawing substituent effective to reduce the reactivity of the aromatic amine curing agent with the phithalonitrile monomer. |
|
| Prostate Cancer Immunotherapy Development in Prostate Specific Antigen Transgenic Mice |
SEP 1999 |
16 pages |
| Authors:
W. M. Kast; LOYOLA UNIV OF CHICAGO IL
|
| Our research is focused towards the development of an immunotherapy for prostate cancer that specifically targets the expressed prostate specific antigen (PSA) of prostate tumor cells. With over forty thousand deaths a year and the near lack of curative treatments, an effective therapy would greatly benefit society. Our research to date has suggested that PSA can serve as a tumor rejection marker in our PSA ... |
|
| Self-Test Kit: Rapid Diagnosis of Urogenital Infections in Military Women |
SEP 1999 |
46 pages |
| Authors:
Daniel V. Landers; MAGEE-WOMEN'S HOSPITAL PITTSBURGH PA
|
| Lower genital tract infections occur commonly among 17-25 year old women and pose a significant problem for military women especially on deployment. This project is to develop a rapid "self-test kit" for common, treatable cervical/vaginal and urinary tract infections. We have completed the developmental phase of the test kit and tested the performance in 486 women with genital complaints. We have also evaluated women's ability to self test and evaluate ... |
|
| Phthalonitrile Thermoset Polymers and Composites Cured With Halogen-Containing Aromatic Amine Curing Agents. |
20 JUL 1999 |
|
| Authors:
Satya B. Sastri; Teddy M. Keller; DEPARTMENT OF THE NAVY WASHINGTON DC
|
| Phthalonitrile thermoset polymers and Composites having flame resistance are formed by combining a phthalonitrile monomer in the melt stage with a halogen-containing aromatic amine curing agent. The halogen-containing aromatic amine curing agent is selected from the group consisting of aromatic amine curing agents having the general formula: NH.-(Ar'O),Ar1-X-Ar1(-OAr1)-NH2, wherein Ar1 and Ar2 are substituted or unsubstituteil aromatic groups, y is O or greater, and X is -C(CF3)2- and aromatic amine ... |
|
| A Solid State 15N NMR Investigation of tbe Cure Reaction Pathways of Bismaleimide/Diarnine Polymers |
SEP 1998 |
|
| Authors:
David B. Curliss; AIR FORCE RESEARCH LAB WRIGHT-PATTERSON AFB OH
|
| The cure reaction pathways of a bismaleinnide resin with a diamine are investigated using solid state 15n NMR spectroscopic techniques with specifically labeled monomers. These techniques provide clear identification of at least three different reaction pathways in the curing resin, one of which has previously been only postulated. In the homopolymerized bismaleimide resin system, maleimide ring addition has previously been shown to be the only observable reaction. When co-reacted with ... |
|
| Self-Test Kit: Rapid Diagnosis of Urogenital Infections in Military Women |
SEP 1998 |
27 pages |
| Authors:
Daniel V. Landers; MAGEE-WOMEN'S HOSPITAL PITTSBURGH PA
|
| Lower genital tract infections occur commonly among 17 - 25 year old women and pose a significant problem for military women especially on deployment. This project is to develop a rapid "self-test kit" for common, treatable cervical/vaginal and urinary tract infections. We have completed the developmental phase of the test kit and proceeded to test the performance in women with genital complaints that will collect and test their own urine ... |
|
| The Effect of a Curing Agent and an Accelerator on the Glass Transition of Brominated and Unbrominated Diglycidyl Ether of Bisphenol A |
MAR 1998 |
13 pages |
| Authors:
Mark F. Fleszar; ARMY ARMAMENT RESEARCH DEVELOPMENT AND ENGINEERING CENTER WATERVLIET NY BENET LABS
|
| Dicyandiamide-a solid with a melting point of 209 deg C-is one of a unique group of curing agents that are insoluble in epoxy at room temperature. As a curing agent for epoxy resins, dicyandiamide can react through all four nitrogen groups--reacting with the resin at both epoxide and hydroxyl sites. When mixed with either diglycidyl ether of bisphenol A or diglycidyl ether of tetrabromobisphenol A, the formulation is stable enough ... |
|
| Phthalonitrile Prepolymerization Composition |
15 JAN 1998 |
19 pages |
| Authors:
Teddy M. Keller; Satya B. Sastri; DEPARTMENT OF THE NAVY WASHINGTON DC
|
| A polymerizable composition suitable for storage prior to polymerization is made by mixing a phthalonitrile monomer and a curing agent under non-reactive conditions below the melting temperatures of the phthalonitrile monomer and the curing agent and in the absence of a solvent to create a homogeneous, unreacted mixture. |
|
| Epoxy Pipeline Composition and Method of Manufacture |
13 JAN 1998 |
|
| Authors:
Robert F. Brady; James D. Adkins; DEPARTMENT OF THE NAVY WASHINGTON DC
|
| A cross-linked pipelining network polymer composition for the in situ rehabilitation of pipes is formed. The polymer composition comprises at least one liquid epoxy resin and an effective amount of a liquid curing agent blend comprising an aliphatic polyamine, an aliphatic imidazoline, and an aliphatic amidoamine. The polymer composition may further comprise a pigment, a diluent and/or a viscosity controlling agent. |
|
| Fiber-Reinforced Phthalonitrile Composite Cured with Low-Reactivity Aromatic Amine Curing Agent |
02 OCT 1997 |
24 pages |
| Authors:
Satya B. Sastri; Teddy M. Keller; DEPARTMENT OF THE NAVY WASHINGTON DC
|
| A fiber-reinforced phthalonitrile composite is made by impregnating or coating a fibrous material with a phthalonitrile prepolymer mixture containing a phthalonitrile monomer and an aromatic amine curing agent that is thermally stable and nonvolatile at a temperature up to about 375 deg C, and that contains at least one electron withdrawing substituent effective to reduce the reactivity of the aromatic amine curing agent with the phthalonitrile monomer. |
|
| Energetic Nitro Polymer |
16 SEP 1997 |
|
| Authors:
G. W. Lawrence; William H. Gilligan; DEPARTMENT OF THE NAVY WASHINGTON DC
|
| Hydroxy-terminated poly(2,2-dinitropropyl) polynitroorthocarbonate prepolymers of the formula (structural formula) which are prepared by reacting bis(2,2-dinitropropyl) dichloroformal with a diol of the formula (structural formula) wherein n>1. and wherein W, X, Y, and Z vary independently and are F or NO2, and wherein -A- is CH2-, -CH2CH2-, -CH2CH2CH2-, -CF2-, -CF2CF2-, -CF2CF2CF2-, -CF2CF2CF2CF2-, -CH2OCH2-, -CH2OCH2OCH2-, -CH2OCF2OCH2-, or -CH2N (NO2)CH2-. These prepolymers are reacted with curing agents (e.g., polyisocyanates) to form energetic polymeric ... |
|
| Energetic Flouronitro Polymer |
16 SEP 1997 |
|
| Authors:
G. W. Lawrence; William H. Gilligan; DEPARTMENT OF THE NAVY WASHINGTON DC
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| Hydroxy-terminated poly(2-fluoro-2,2-dinitroethyl) polynitroorthocarbonate prepolymers of the formula (structural formula) which are prepared by reacting bis(2-fluoro-2,2-dinitroethyl)dichloroformal with a diol of the formula (structural formula) wherein n>1, and wherein W, X, Y, and Z vary independently and are F or NO2, and wherein A is -CH2-, -CH2CH2-, -CH2CH2CH2-, -CF2-, -CF2CF2-, -CF2CF2CF2-, -CF2CF2CF2CF2-, -CH2OCH2-, -CH2OCH2OCH2-, -CH2OCF2OCH2-, or CH2N (NO2)CH2-. These prepolymers are reacted with curing agents (e.g., polyisocyanates) to form energetic polymeric binders. ... |
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| Stereolithography Apparatus for Free Form Fabrication of Ceramics |
25 AUG 97 |
24 pages |
| Authors:
John W. Halloran; MICHIGAN UNIV ANN ARBOR DEPT OF MATERIALS SCIENCE AND ENGINEERING
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| During this grant we installed a 3D Systems SLA 250/40 stereolithography apparatus, and used it to directly fabricate ceramic green bodies from ultraviolet (UV) curable solutions which contain dispersed ceramic powders. We emphasized SLA of alumina as a structural ceramic and for investment casting cores. Viscosity was reduced with improved dispersion. The quality of the prototypes was improved by determination of appropriate build styles, and by optimization of photoinitiators and ... |
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| Comparative Drug Response of Sensitive and Resistant Strains of Malarial Parasites Using in vitro Bioassays and Animal Models |
MAR 97 |
109 pages |
| Authors:
V. P. Kamboj; CENTRAL DRUG RESEARCH INST LUCKNOW (INDIA)
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| No escalation of curative doses of reference drugs (chloroquine and primaquine) in the simian radical curative models has been recorded over the last 14 years. A shorter 3- dose regimen of WR 238605 for anti-relapse activity has been established which would be operationally more acceptable. In addition this compound as exhibited significant blood-schizontocidal, prophylactic and gametocytocidal activities which can be exploited. A new anti-relapse regimen comprising of WR 238605 plus ... |
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