| Using Propranolol to Block Memory Reconsolidation in Female Veterans with PTSD |
Oct 2011 |
5 pages |
| Authors:
Deane Aikins; YALE UNIV NEW HAVEN CT
|
 | One of the hallmark features of Posttraumatic Stress Disorder (PTSD) is a marked increased in physical arousal (i.e., increased heart rate, muscle tension, etc.) when recalling a trauma-related memory. In this manner, a treatment that decreased the hyper-arousal of a traumatic memory to less-impairing levels may do well in allowing an individual with PTSD to return to his or her daily life. However, there is an imbalance at the heart ... |
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| A Psychophysiologic Study of Weakening Traumatic Combat Memories with Post-Reactivation Propranolol |
Jun 2011 |
16 pages |
| Authors:
Roger K Pitman; MASSACHUSETTS GENERAL HOSPITAL BOSTON
|
| Introduction: The eta-adrenergic blocker propranolol has been shown to reduce reconsolidation of aversive memories in rodents. Administration of propranolol following reactivation of traumatic memories in male and female civilians with PTSD has been shown to reduce physiological responses during subsequent mental imagery the traumatic event. Aims: The present study aimed to examine whether the fear-weakening effect of propranolol may be due to non-specific actions of the drug. Here we investigated ... |
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| A Randomized Controlled Trial of Medical Therapies for Chronic Post-Traumatic Headaches |
May 2011 |
8 pages |
| Authors:
Jay Erickson; HENRY M JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE ROCKVILLE MD
|
| A randomized, double-blinded, placebo-controlled clinical trial was conducted to evaluate the effectiveness of propranolol, topiramate, and amitriptyline as treatments for chronic post-traumatic headaches secondary to combat-related mild head injury. The study has completed the third of three years. 305 soldiers with chronic PTH were screened and 64 were enrolled, falling well short of the enrollment target of 240 subjects. 39 (61%) had evaluable data after drug titration and 34 (53%) ... |
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| Tc-99m Labeled and VIP-Receptor Targeted Liposomes for Effective Imaging of Breast Cancer |
01 SEP 2006 |
88 pages |
| Authors:
Hayat Onyuksel; ILLINOIS UNIV AT CHICAGO
|
| However, current methods of breast cancer detection cannot provide accurate results. This study was conceived to begin to address this issue by developing and testing a novel method of active targeting of radionuclide (Tc-99m) encapsulating sterically stabilized liposomes (SSL) for gamma scintigraphic imaging of breast cancer. This non-invasive imaging modality utilizes both overexpression of vasoactive intestinal peptide (VIP) receptors in breast tumor and distinct biology of the tumors (leaky vasculature) ... |
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| Comparison of Pilot Medical History and Medications Found In Postmortem Specimens |
MAY 2006 |
7 pages |
| Authors:
Dennis V. Canfield; Guillermo J. Salazar; Russell J. Lewis; James E. Whinnery; FEDERAL AVIATION ADMINISTRATION OKLAHOMA CITY OK CIVIL AEROMEDICAL INST
|
| Pilots are required by FAA regulations to report all medications and medical conditions to the FAA Office of Aerospace Medicine for review as to the overall suitability of the pilot for flight activities. Following a fatal aviation accident, specimens from deceased pilots are collected by local pathologists and sent to the Bioaeronautical Sciences Research Laboratory (BSRL) for toxicological analysis. The results of such tests are entered into the BSRL Forensic ... |
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| Simultaneous Quantitation of Atenolol, Metoprolol, and Propranolol in Biological Matrices Via LC/MS |
MAY 2005 |
20 pages |
| Authors:
Robert D. Johnson; Russell J. Lewis; FEDERAL AVIATION ADMINISTRATION WASHINGTON DC OFFICE OF AVIATION MEDICINE
|
| Hypertension is a growing medical concern in the United States. With the number of Americans suffering from hypertension increasing, the use of antihypertensives such as beta-blockers is increasing as well. In fact, three beta-blockers - atenolol, metoprolol and propranolol - were among the 200 most prescribed medications in the United States in 2003. Pilots that successfully manage their hypertension can remain certified to fly. The Federal Aviation Administration currently designates ... |
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| Antigen-Independent Methods to Improve Radioimmunotherapy of Prostate Cancer |
DEC 2004 |
16 pages |
| Authors:
Janina Baranowska-Kortylewicz; NEBRASKA UNIV MEDICAL CENTER OMAHA
|
| These studies were designed to improve the outcome of radioimmunotherapy (RIT) in prostate adenocarcinoma by the inclusion of vasoactive peptides in the RIT protocol. To date three peptides able to modify vascular permeability (VP) were tested. Cytotoxicity studies indicated dose- dependent changes in cell metabolic activities after treatment with two agonists interacting with CD88 (C5aAP peptides); whereas one peptide interactive with a formyl peptide receptor-like I did not seem to ... |
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| Gas Chromatographic/Mass Spectrometric Differentiation of Atenolol, Metoprolol, Propranolol, and an Interfering Metabolite Product of Metoprolol |
OCT 2004 |
9 pages |
| Authors:
Mike K. Angier; Russel J. Lewis; Arvind K. Chaturvedi; Dennis V. Canfield; FEDERAL AVIATION ADMINISTRATION OKLAHOMA CITY OK CIVIL AEROMEDICAL INST
|
| Pilots who successfully control their hypertension with medications, diet, and/or exercise can be medically certified to fly an aircraft. At the present time, approximately 8% of active pilots are designated as "hypertensive with medication" by the Federal Aviation Administration (FAA). One of the groups of antihypertensives is the beta-blocker. Of this group, atenolol, metoprolol, and propranolol are commonly prescribed, and they also have chemical and structural similarities. The FAA's Civil ... |
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| Technical Evaluation Report (HFM Panel Symposium) |
01 SEP 2004 |
|
| Authors:
Howard Champion; NATO RESEARCH AND TECHNOLOGY ORGANIZATION NEUILLY-SUR-SEINE (FRANCE)
|
 | In ground based tactical situations casualties can not be avoided. It is well documented that immediate haemostatic surgery can be life saving, and the most significant factor for survival is the time from injury to surgery. Late complications like septicemia and multi organ failure are in most cases sequelae of the initial hypo perfusion. In situations where evacuation will be delayed, the prehospital handling and management are of critical importance. ... |
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| Computer Simulation of Electrical Propagation in Cardiac Tissue |
25 OCT 2001 |
|
| Authors:
T. Arafune; A. Mishima; E. Kobayashi; I. Sakuma; H. Inada; TOKYO UNIV (JAPAN)
|
| The purpose of the present research is to analyze the behavior of the reentrant spiral wave, which is one of the main causes of sudden cardiac death using computer simulation models of cardiac excitation propagation, The simulation model is a two dimensional electric circuit network model where many electric circuit models of cardiac membrane action potential were connected with electric resistance standing for intra-and extra cellular conductance, As cardiac membrane ... |
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| Measurement of Contraction of Isolated Cardiomyocytes During Anoxia/ Reoxygenation and the Antagonism of Salvia Miltiorrhiza |
25 OCT 2001 |
|
| Authors:
W. H. Xu; Q. Xia; C. M. Cao; C. Y. Zhu; X. D. Wu; ZHEJIANG UNIV HANGZHOU (CHINA)
|
| The purpose of the present study was to determine the alterations of contraction parameters in isolated cardiomyocyte under anoxia and reoxygenation by using a video tracking system developed by us and examine the pharmacological application of this system to determine the effect of Salvia miltiorrhiza (SM) on anoxia and reoxygenation-induced mechanical changes. The results showed that the parameters measured were stable and consistent with those determined by other commercial device. ... |
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| Vibrio Cholerae Binding to Carbohydrates |
MAR 97 |
|
| Authors:
Sheila Wood; Ron Schnaar; JOHNS HOPKINS UNIV BALTIMORE MD SCHOOLOF MEDICINE
|
| Vibrio cholerae is a pathogen that produces a vasoactive toxin and three previously described adhesive factors. The adhesive factors are inhibited by mannose, fucose, or n-acetylglucosamine. The entire relevance of these factors is not clear, but it is thought that they may play a role in the virulence of V.cholerae by allowing the organism to attach to and colonize the bowel. Our investigation tested the ability of snythesized neoglycoproteins to ... |
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| The Effects of Ricin on the Heart and Coronary Arteries |
01 FEB 95 |
189 pages |
| Authors:
Casey P. Robinson; OKLAHOMA UNIV OKLAHOMA CITY COLL OF MEDICINE
|
| Effects of ricin on rabbit heart, coronary arteries, and distribution of blood flow to various organs and tissues were investigated. Ricin increased cardiac output, and blood flow to most organs/tissues. Ricin was given 0.22 micrograms/kg and 48 hours later changes were determined. Ricin decreased sensitivities of coronary arteries to 5-HT- and histamine contractions, increased sensitivity to NE relaxations, increased maximal contractions, but did not alter ACh-induced relaxations. Ricin increased basal ... |
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| Neuropeptide-Y (NPY) Increases Total Blood Flow in the Tail, and Reduces Cutaneous Microvascular Blood Flow in the Tail and Foot of the Rat |
10 FEB 93 |
22 pages |
| Authors:
M. E. Heath; J. R. Thomas; NAVAL MEDICAL RESEARCH INST BETHESDA MD
|
| The purpose of this study was to describe the in vivo effects of neuropeptide-Y (NPY) on total blood f low (BF sub T) and on microvascular skin blood flow (BF sub sk) in appendages of a whole animal model. This study is important to understanding the medical relevance of NPY in cardiovascular physiology. The tail and foot of the rat were used as the model. BF sub sk and skin ... |
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| Substance P and Related Peptides: Cellular and Molecular Physiology. Annals of the New York Academy of Sciences. Volume 632 |
01 OCT 91 |
|
| Authors:
Susan E. Leeman; NEW YORK ACADEMY OF SCIENCES NY
|
| This symposium included the following topics: Developmental and Hormonal Regulation of the Sex Difference in Preprotachykinin Gene Expression in Rat Anterior Pituitaries, Regulation of Substance P Expression in Sympathetic Neurons; Effect of Lymphokines on Substance P in Injured Ganglia of the Peripheral Nervous System; Preprotachykinin Gene Expression in the Forebrain: Regulation by Dopamine; Differential Changes in Tachykinins in the Rat Brain after Drug-induced Seizures; Functional Role of Substance P for ... |
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| Neurochemical Control of Circadian Rhythms |
20 FEB 90 |
17 pages |
| Authors:
H. E. Albers; GEORGIA STATE UNIV ATLANTA
|
| The suprachiasmatic nucleus (SCN), which appears to act as a circadian clock, contains a large subpopulation of local circuit neurons in which vasoactive intestinal peptide (VIP) and peptide histidine isoleucine (PHI) are co-localized. We are continuing to investigate the hypothesis that VIP/PHI- containing neurons are essential for the synchronization of circadian rhythms with the day-night cycle. Using in situ hybridization, we demonstrated that some, but not all SCN neurons that ... |
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| Isolation of a Toxin from Venom of Wagler's Pit Viper Trimeresurus wagleri |
31 JAN 90 |
22 pages |
| Authors:
Scott A. Weinstein; Alan W. Bernheimer; Leonard A. Smith; ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD
|
| A lethal toxin was isolated from Trimeresurus wagleri venom by fast protein liquid chromatography (molecular sieve) and Biorex-70 cation exchange. The toxin had an M(r) of approximately 9.5 kD, a pl of 9.6-9.9, did not exhibit subunit behavior in SDS-PAGE profiles and lacked phospholipase A, proteolytic, and hemolytic activity. The toxin had an i.p. LD(50) of 0.072 mg/kg. The lethal activity was found to represent less than 1% of the ... |
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| Cachectin/Tumor Necrosis Factor and the Pituitary-Adrenal Axis |
06 APR 89 |
19 pages |
| Authors:
Diana S. Malcom; Merrily Poth; UNIFORMED SERVICES UNIV OF THE HEALTH SCIENCES BETHESDA MD
|
| Preliminary studies investigating immune-neuroendocrine interactions have yielded several interesting and novel findings. Intravenous injections of low doses of TNF (0.01-0.10 mg/kg) in unanesthetized animals resulted in significant elevations in circulating ACTH and corticosterone. These low doses of TNF did not produce changes in mean pressure but did increase heart rate within 5-10 minutes post-injection. In vitro, TNF was shown to inhibit ACTH- stimulated corticosterone adrenal cells. Similarly, TNF inhibited TSH-stimulated ... |
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| Neurochemical Control of Circadian Rhythms |
20 MAR 89 |
9 pages |
| Authors:
Albers H. Elliott; GEORGIA STATE UNIV ATLANTA
|
| We have continued our investigation of the neurochemical systems contained in the circadian clock localized within the suprachiasmatic nucleus (SCN). Our primary focus has been to determine the circadian functions of a subpopulation of SCN interneurons in which vasoactive intestinal peptide (VIP), peptide histidine isoleucine (PHI) and gastrin releasing peptide (GRP) have been co-localized. In these studies we have demonstrated: 1) VIP/PHI neurons are found in the ventrolateral SCN where ... |
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| Influence of Altitude and Caffeine during Rest and Exercise on Plasma Levels of Proenkephalin Peptide F |
FEB 88 |
|
| Authors:
William J. Kraemer; Paul B. Bock; Charles S. Fulco; Scott E. Gordon; Jeff P. Bonner; ARMY RESEARCH INST OF ENVIRONMENTAL MEDICINE NATICK MA
|
| The purpose of this study was to examine the resting and exercise response patterns of plasma Peptide F immunoreactivity (ir) to altitude exposure (4300m) and caffeine ingestion (4mg.KgBW-1). Nine healthy male subjects performed exercise tests to exhaustion at sea level, during an acute altitude exposure (1 hr. hypobaric chamber) and after a chronic (17 day sojourn) altitude exposure. Using a randomized, double-blind/placebo experimental design, a placebo or caffeine drink was ... |
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| Measurement of Electrical Activity in the CNS with Cortical Evoked Potentials and EEG: Efficacy Profiles of Drugs Using Factor Analysis, |
FEB 1988 |
|
| Authors:
David Johnson; Albrecht Frauendorf; Kurt Offenloch; ADVISORY GROUP FOR AEROSPACE RESEARCH AND DEVELOPMENT NEUILLY-SUR-SEINE (FRAN CE)
|
| In a series of experiments with 20 healthy, subjects per substance, the influences of a new nootropic drug and three cardiovascular agents on the CNS were measured and placebo controlled. The EEG and visual cortical evoked potentials were recorded from electrode position ''Oz'' between O1 and O2 according to the 10-20 system. Three channels of the visual system were selectively stimulated (contrast, brightness and colour using checkerboard, flash and colour ... |
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| The Redox Chemistry of 5-Imino-7-Deoxydaunomycinone. The Preparation and Characterization of Leuco Daunomycin (8S-cis)-8-Acetyl-10-((3-Amino-2,3,6- Trideoxy-alpha-L-Lyxo-Heopyranosyl)Oxy)-6a,7,8,9,10,10a-Hexahydro-5,8,12- Trihydroxy-1-Methoxy-6,11-Naphtha |
88 |
|
| Authors:
Donald M. Bird; AIR FORCE INST OF TECH WRIGHT-PATTERSON AFB OH
|
| Because of the cardiotoxic effects of anthracycline anti-tumor drugs, many have sought to modify daunomycin chemically in an effort to reduce the cardiotoxicity and enhance or maintain the cytotoxicity. 5-Imminodaunomycin is one such derivative in which the carbonyl at C-5 has been modified to produce an iminoquinone which retains the cytotoxicity with significantly reduced cardiotoxicity. The reason for the reduced cardiotoxicity has been attributed in the literature to being both ... |
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| Ketanserin Modulates Rabbit Foot Cooling in the Presence or Absence of Exogenous Serotonin |
15 JUL 87 |
|
| Authors:
D. A. DuBose; M. Lukason; R. Mariano; R. Harris; G. Silver; ARMY RESEARCH INST OF ENVIRONMENTAL MEDICINE NATICK MA
|
| Because hypothermic conditions augment sensitivity to vasoactive amines like serotonin (5-HT) and 5-HT is associated with the etiology of Raynaud's phenomenon, this amine perhaps plays a role in cold-induced vasoconstriction. To determine if 5-HT participated in normal peripheral cooling and if Ketanserin (KET), a 5-HT blocker, modulated such cooling, four groups of New Zealand white rabbits were studied. The femoral artery was cannulated to allow perfusion of a hindlimb. A ... |
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| Agent Effects on the Vascular Neuroeffector System |
01 MAY 87 |
|
| Authors:
Casey P. Robinson; Chao-Yu Hu; OKLAHOMA UNIV HEALTH SCIENCES CENTER OKLAHOMA CITY
|
| The effects of soman on the resting contractile tension of human uterine arteries and on the contractions of these arteries to vasoactive agents were investigated. Soman did not alter the resting tension of helically cut strips of human uterine arteries. Soman did not alter concentration-response curves of the strips to norepinephrine, serotonin, potassium chloride, or histamine. Soman increased contractile tension of human uterine artery strips to subsequently added 1 micromole ... |
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| Cutaneous Blood Flow and Local Sweating After Systemic Atropine Administration |
DEC 86 |
|
| Authors:
Margaret A. Kolka; Lou A. Stephenson; ARMY RESEARCH INST OF ENVIRONMENTAL MEDICINE NATICK MA
|
| Localized cutaneous vasodilation (flush) is seen following systemic atropine administration. To verify calculated enhanced dry heat loss with actual changes in cutaneous blood flow, four men were studied in both control and atropine experiments during moderate exercise. Esophageal temperature (Tes) and arm sweating (ms) by local dewpoint were measured continuously. Skin (forearm) blood flow (FBF) was measured twice each minute by venous occlusion plethysmography. Injection of atropine (2 mg) caused ... |
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| Review of Modified Hemoglobin Solutions for Use as Temporary Blood Substitutes |
DEC 85 |
|
| Authors:
Lucjan J. J. Hronowski; DEFENCE AND CIVIL INST OF ENVIRONMENTAL MEDICINE DOWNSVIEW (ONTARIO)
|
| The present review will focus on blood substitutes using hemoglobin solutions as oxygen carriers. It will review the more recent developments and discuss the limitations and problems associated with the present hemoglobin preparations. This will be covered under the headings of purification of hemoglobin, modification and polymerization of the hemoglobin molecule and the biological activities of the hemoglobin solutions. Polymerization of hemoglobin is currently the only means of obtaining a ... |
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| Specific Cardiovascular Drugs Utilized in the Critically Ill |
NOV 1985 |
16 pages |
| Authors:
Steven Teich; Bart Chernow; NAVAL MEDICAL RESEARCH INST BETHESDA MD
|
| The ability to manipulate the function of the heart and peripheral vasculature is requisite for the management of many critically ill patients. For each clinical situation, a wide scope of cardiovascular agents is available. In this article we review the clinical indications and cardiovascular effects of catecholamines, opioid peptide antagonists, prostaglandin inhibitors, calcium, glucagon, calcium channel blockers, and other agents. We also present possible new indications for conventional drugs and ... |
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| International Montreux Conference of Chronopharmacology |
FEB 85 |
|
| Authors:
M. H. Smolensky; TEXAS UNIV AT HOUSTON SCHOOL OF PUBLIC HEALTH
|
| The report which follows is divided into the following three sections: (1) overview summary of the First Montreux International Congress of Chronopharmacology, (2) listing of the participants supported by this contract and (3) 5 copies of the proceedings as stipulated by the contract. Papers delivered at the First Montreux Conference dealt with 8 major themes as outlined below: Neurobiology; Antihistamines and Bronchodilators; Anticancerous Medications; Statistics, Methods and Instrumentation, including Pumps; ... |
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| Cardiopulmonary Response to Shock |
30 SEP 82 |
|
| Authors:
Herbert B. Hechtman; HARVARD UNIV CAMBRIDGE MA
|
| A major hypothesis that clinical events such as endotoxemia and ischemia which could lead to shock stimulate platelet and white blood cell (WBC) secretions which modify cardiopulmonary function has undergone further scrutiny. Particular attention has been paid to the role of arachidonic acid derivatives. Several common events have been found which simulate the production of Tx such as exposure of blood to foreign surfaces, positive end-expiratory pressure ventilation and pulmonary ... |
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| Pulmonary Response to Hemorragic Shock. |
24 FEB 1978 |
|
| Authors:
Herbert B. Hechtman; HARVARD UNIV BOSTON MA
|
| Studies have shown that positive end expiratory pressure (PEEP) may induce a humorally mediated decrease in cardiac output. The agent is secreted as a result of lung stretch and acts on the heart to decrease contractility. |
|
| The Effect of Vasodilator Drugs (Roniacol and Priscoline) on Skin Temperatures and Blood Flow During Mild Cold Stress. |
FEB 1977 |
|
| Authors:
W. S. Myles; S. D. Livingstone; DEFENCE AND CIVIL INST OF ENVIRONMENTAL MEDICINE DOWNSVIEW (ONTARIO)
|
| Two vasodilator drugs (Roniacol and Priscoline) were tested for their potential prophylactic effect in the prevention of cold-induced vasoconstriction in the hands of human subjects during exposure to mild cold stress. The drugs were administered as a single dose by mouth (300 mg Roniacol or 50 mg Priscoline) to nude subjects lying quietly for 90 minutes at 21 C. Skin temperatures were measured at the left middle finger, the left ... |
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| Neurohumoral Control Mechanisms in the Regulation of Cardiovascular Function and Fluid and Electrolyte Balance. |
30 SEP 1976 |
|
| Authors:
P. D. Gupta; DELHI UNIV (INDIA) V P CHEST INST
|
| Changes in cardiac output and peripheral resistance, and changes in the venous tone following bleeding and transfusion, and their correlation with the cardiac and sino-aortic receptor drive were studied. Additional studies were made of cardio-acceleratory sympathetic afferent pathways, physiology of Arterio-Venous(A-V) shunts, including the mechanism underlying cardiovascular adjustment in A-V shunts, and cardiovascular receptors discharge in A-V shunts. Also studied were the response of vagal afferents in shock and fainting, ... |
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| The Effect of a Simulated Subarachnoid Hemorrhage on Cerebral Blood Flow in The Monkey. |
MAR 1976 |
|
| Authors:
A. N. Martins; T. F. Doyle; N. Newby; A. I. Kobrine; A. Ramirez; ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD
|
| The hydrogen clearance method was used to measure local and total cerebral blood flow (CBF) in the rhesus monkey before and for 5 hours after a simulated subarachnoid hemorrhage (SAH). CBF remained stable after SAH unless SAH was associated with a fall in cerebral perfusion pressure. In addition, cerebrovascular resistance did not increase after SAH. These results suggest that vasoactive agents in fresh whole blood, and the arterial spasm they ... |
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| Present Concepts in Internal Medicine, Cardiology Symposium, 1976, |
1976 |
|
| Authors:
Gabriel Gregoratos; Lottie B. Applewhite; Cathleen E. Swee; LETTERMAN ARMY MEDICAL CENTER SAN FRANCISCO CALIF
|
| The symposium consists of ten articles and three tables (for quick reference). It focuses on the management and treatment of cardiac arrhythmias. It is designed for use by interns and residents who are faced with treating pathients with arrhythmias. This monograph is a compilation of up-to-date information on available anti-arrhythmic agents. The lead article presents a summary of current knowledge about the electrophysiologic genesis of arrhythmias. The succeeding six articles ... |
|
| Biochemical Studies on the Mechanism of Drug Action. |
OCT 1973 |
|
| Authors:
Myron A. Mehlman; Richard B. Tobin; Beverly A. Friend; NEBRASKA UNIV AT OMAHA DEPT OF BIOCHEMISTRY
|
| The primary objectives of this research project were to study the mechanism of action of three common drugs, theophylline, acetylsalicylic acid and diphenylthiohydantoin (DPTH), in normal and thiamin deficient rats. |
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| Release of Histamine from Mast Cells by Vasoactive Peptides. |
12 FEB 1973 |
|
| Authors:
Ervin G. Erdoes; Alice R. Johnson; OKLAHOMA UNIV HEALTH SCIENCES CENTER OKLAHOMA CITY
|
| The effect of a variety of synthetic pepides on rat mast cells was investigated. Peptides with two or more basic groups were active histamine releasers, while eledoisin, angiotensin I and II, glucagon, and fibrinopeptide A had slight or no activity. The activity of bradykinin analogues increased with the chain length. Des-arginine derivatives of bradykinin did not release histamine. The most potent histamine liberators were substance P and polistes kinin; the ... |
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| Immune Hemolytic Transfusion Reactions in Monkeys: Activation of the Kallikrein System. |
30 JUN 1972 |
|
| Authors:
Harry Lopas; Norman I. Birndorf; C. Elliott Bell Jr.; Stanley J. Robboy; Robert W. Colman; ARMY MEDICAL RESEARCH LAB FORT KNOX KY
|
| Five monkeys were infused with isologous, isoimmune IgG of high hemolytic titer, and five control monkeys received isologous or autologous nonimmune IgG. The former experienced severe intravascular hemolysis, manifested by a fall in hematocrit and a rise in plasma hemoglobin, and disseminated intravascular coagulation (DIC), manifested by a fall in platelet count, fibrinogen, factor V, VIII, and X concentrations and prolongation of thrombin time. The plasma kallikrein system was activated ... |
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| The Mesentric Circulation in Diarrheal Diseases. |
10 MAY 1972 |
|
| Authors:
Eugene D. Jacobson; TEXAS UNIV MEDICAL SCHOOL AT HOUSTON
|
| Investigations were conducted to understand the role of the intestinal circulation in response to naturally occurring vasoactive substances, to drugs, to shock states and to increases in either intestinal motor activity or tension of the gut wall. In addition, the hydrodynamics of a diarrheal model were studied. Primary methods employed included use of anesthetized dogs and monkeys, measurement of mesenteric blood flow, gut and blood preessures with implanted flow or ... |
|
| Present Concepts in Internal Medicine. Volume V. Number 5. Cardiology Symposium, |
MAY 1972 |
|
| Authors:
Gabriel Gregoratos; Lottie Applewhite; LETTERMAN GENERAL HOSPITAL SAN FRANCISCO CALIF
|
| The cardiology symposium (1972) consists of nine papers prepared for internists. The first paper reviews the data on the natural history of the three most common congenital anomalities - atrial septal ductus, patent ductus arteriosus, ventricular septal defect - with particular emphasis on their ultimate fate in adult life. The next three papers discuss the conditions separately, i.e. the clinical diagnosis and management. A review of the current status of ... |
|
| Mechanism of Action of Adenosine 3',5'-Monophosphate. |
01 JUL 1971 |
|
| Authors:
Robert A. Levine; STATE UNIV OF NEW YORK BROOKLYN DOWNSTATE MEDICAL CENTER
|
| The effects of cyclic AMP, other cyclic nucleotides and prostaglandins on hepatic metabolic function and gastrointestinal function have been studied. Cyclic AMP or its dibutyryl derivative were shown in vivo to stimulate heart rate, increase systolic blood pressure minimally, increase plasma glucose, cortisol, insulin, latently increase plasma growth hormone, affect plasma free fatty acids (decrease followed by increase), increase urine osmolality, produce antidiuresis and inhibit gastric secretion and intestinal motility. ... |
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| Studies on Cardiotoxin and Vasoactive Substance Releasing Component(s) of Cobra Venom. Comparison of Hemodynamic Effects of Cardiotoxin with those of Cobra Venom |
MAR 1971 |
21 pages |
| Authors:
Chen-Yuan Lee; NATIONAL TAIWAN UNIV TAIPEI PHARMACOLOGICAL INST
|
| The effects of cardiotoxin on the cardiovascular system has been studied in comparison with those of crude venom of Formosan cobra. The intravenous injection of cardiotoxin (1.0 mg/kg) usually produces an immediate rise in systemic arterial pressure, followed by a progressive decline leading to cardiac arrest, whereas a precipitous fall in systemic arterial pressure is usually observed with crude venom (0.5 - 1.0 mg/kg). A very marked increase in both ... |
|
| Research in Intravascular Coagulation at Karolinska Institute, Stockholm, Sweden, |
04 DEC 1970 |
|
| Authors:
Clifford M. Herman; OFFICE OF NAVAL RESEARCH LONDON (ENGLAND)
|
| One of the primary research interests in the Thoracic Clinic of the Karolinska Institute is the hemodynamic changes occurring in the state of DIC. In investigating the mechanisms by which intravascular clotting affects vascular tone and tissue perfusion, it was found that platelets released vasoactive adenine nucleotides during thrombin infusion into defibrinogenated dogs. These nucleotides then caused vasodilatation and decreased vascular resistance. Defibrinogenation has also been shown to prevent clotting ... |
|
| Inhibition by Thyrocalcitonin (Calcitonin) of the Cyclic AMP-Mediated Stimulation of Thymocyte Proliferation by Epinephrine, |
03 DEC 1970 |
|
| Authors:
J. F. Whitfield; J. P. MacManus; D. J. Gillan; NATIONAL RESEARCH COUNCIL OF CANADA OTTAWA (ONTARIO) DIV OF BIOLOGY
|
| Epinephrine stimulates the proliferation of rat thymic lymphocytes maintained in vitro by a cyclic AMP-mediated process. The mitogenic action of epinephrine is completely inhibited by low concentrations (6.0 to 8.0 mU per ml) of a highly purified sample of porcine thyrocalcitonin (calcitonin). In view of the fact that the same low levels of thyrocalcitonin are known to inhibit the cyclic AMP-mediated mitogenic action of vasopressin and the similar physiologically important ... |
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| DOSE-RESPONSE EFFECTS OF CARDIAC GLYCOSIDES ON POOLING AND SYSTEMIC AND PULMONARY HEMODYNAMICS. |
03 APR 1970 |
|
| Authors:
Linda T. Archer; Lerner B. Hinshaw; OKLAHOMA UNIV MEDICAL CENTER OKLAHOMA CITY
|
| The effects of ouabain and digoxin on systemic and cardiopulmonary circulations and the degree and site of vascular pooling were evaluated in this study. A major emphasis was placed on the relationship of dosage to responses observed. Experiments were performed on 32 adult mongrel dogs using a venous return preparation. Animals were divided into two groups, intact and eviscerated. Mean cumulative doses were: 27, 55, and 81 ug/kg for intact ... |
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| RESPONSES OF THE VASCULAR SYSTEM IN RELATION TO THE HORMONE BACKGROUND. |
31 OCT 1969 |
|
| Authors:
L. M. Pickford; EDINBURGH UNIV (SCOTLAND) DEPT OF PHYSIOLOGY
|
| This report discusses work on the actions and possible functions of the neurohpophysical hormones, vasopressin and oxytocin (apart from those already recognized) and in particular their relationship to the vascular system, and in what way the activity of these two substances is changed when the gonadal hormone and other hormone background alters. The main objective was to throw some light on why there are differences in time of life when ... |
|
| HEMODYNAMICS OF THE MESENTERIC CIRCULATION. |
23 JUN 1969 |
|
| Authors:
Eugene D. Jacobson; Gerhard A. Brecher; OKLAHOMA UNIV MEDICAL CENTER OKLAHOMA CITY
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| The objectives of this project are to define the relationship between intestinal motor activity and blood flow, mesenteric circulatory responses to naturally occurring vasoactive agents, and the relationship between blood flow and intestinal absorption. The approach has been to use the intact canine mesenteric circulation and gut as the experimental model, measuring blood flow and pressures and intestinal pressure with transducers. Appropriate pharmacological agents were delivered directly into the circulation. ... |
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| PHYSIOLOGICAL ACTIVITY OF THE BROWN ADIPOSE TISSUE. |
16 APR 1969 |
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| Authors:
Shinju Ito; HOKKAIDO UNIV SAPPORO (JAPAN) DEPT OF PHYSIOLOGY
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| Studies were performed to clarify the influence of various factors which might be involved in vascular regulation. Topical application of lidocain and treatment with reserpine effectively blocked, while denervation of brown fat, syrosingopine and atropine were ineffective to prevent the blood flow increase in response to cold exposure. The blood flow in brown fat is likely to be regulated by multiple factors. In vitro experiments were carried out in order ... |
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| CLINICAL INVESTIGATION. |
JUL 1968 |
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| Authors:
MADIGAN GENERAL HOSPITAL TACOMA WASH
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| Contents: Oral cryosurgery; tissue response; wound healing; young adult rats; meningococcal sepsis; coagulation abnormalities; mechanisms; anemia; granulocytopenia; plasmodium vivax malaria; effect; early intravenous feedings; premature infants; chromosome analyses; children; congenital malformations; antacid therapy; oral glucose; balloon implants; rubella; lenticular subcapsular; epithelium; immunization; meningococcal disease; acrylic teeth; triatiated digoxin; routine physical; betadine; intrauterine; instrumentation; sterility; primary hemostasis; mycoplasma pneumoniae pneumonia; background incidence; allergic contact dermatitis; free milk samples; palatal anomalies; respiratory ... |
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| RESPONSES OF THE VASCULAR SYSTEM IN RELATION TO THE HORMONE BACKGROUND. |
30 JUN 1968 |
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| Authors:
L. M. Pickford; EDINBURGH UNIV (SCOTLAND) DEPT OF PHYSIOLOGY
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| BLOOD FLOW STUDIES IN MAN IN SHOCK. |
MAR 1968 |
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| Authors:
David H. Lewis; GOTEBORG UNIV (SWEDEN)
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| Studies on total flow, nitritional flow, and non-nutritional (shunt) flow in skeletal muscle in the dog, using the rubidium extraction method, reveal that with hemorrhagic shock or soft tissue trauma, the normal inverse relationship between total flow and nutritional flow is preserved. Soft tissue trauma causes an immediate, transient, increase in non-nutritional flow, which is due to physiological shunting and not true A-V anastomotic shunting. A simple double-isotope method, which ... |
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Reports by Keyword(s)
CARDIOVASCULAR AGENTS
