| TARGET (Translational Approaches for the Reversal, Genetic Evaluation and Treatment) of Lung Cancer |
SEP 2006 |
347 pages |
| Authors:
Waun K. Hong; Fadio R. Khuri; M D ANDERSON CANCER CENTER HOUSTON TX
|
 | TARGET is focused on a series of projects designed to obtain data in the preclinical and clinical settings to help us further the epidemiology of lung cancer, the molecular biology, genetics and epigenetics of lung cancer in the context of tobacco-damaged aerodigestive tract tissue, and the antic-cancer activity of several promising new agents, and various treatment and drug delivery approaches in models of lung cancer and other aerodigestive tract tumors. ... |
|
| Cynomolgus Macaque as an Animal Model for Severe Acute Respiratory Syndrome |
MAY 2006 |
11 pages |
| Authors:
James V. Lawler; Timothy P. Endy; Lisa E. Hensley; Aura Garrison; Elizabeth A. Fritz; May Lesar; Ralph S. Baric; David A. Kulesh; David A. Norwood; Leonard P. Wasieloski; ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD
|
| The emergence of severe acute respiratory syndrome (SARS) in 2002 - 2003 had a tremendous global impact. Adequate animal models are required to study the underlying pathogenesis of SARS-associated coronavirus (SARS-CoV) infection and to develop effective vaccines and therapeutics. In order to characterize clinically relevant parameters of SARS-CoV infection in non-human primates, we infected cynomolgus macaques with SARS-CoV in three groups: Group I was infected in the nares and bronchus, ... |
|
| Acute Lung Injury Following Smoke Inhalation: Predictive Value of Sputum Biomarkers and Time Course of Lung Inflammation |
APR 2006 |
51 pages |
| Authors:
Jefferey L. Burgess; ARIZONA UNIV TUCSON
|
| The role of lung inflammatory mediators in the development of lung injury following smoke inhalation is unknown. To evaluate the predictive value and role of inflammatory mediators in acute lung injury following smoke inhalation. Specific aims: 1) Determine the predictive value of initial inflammatory markers in bronchial secretions of smoke inhalation victims for subsequent lung injury. 2) Measure longitudinal changes in inflammatory mediators in smoke inhalation victims. Study design: Bronchial ... |
|
| V.I.T.A.L. (Vanguard Investigations of Therapeutic Approaches to Lung Cancer) |
JAN 2005 |
86 pages |
| Authors:
Waun K. Hong; M D ANDERSON CANCER CENTER HOUSTON TX
|
| The VITAL Research Program has three primary objectives that are being addressed through a series of innovative and integrated research studies: (1) to develop biologically-based treatments for the prevention of disease recurrence and of the development of second primary tumors in patients at risk for these events, (2) to improve understanding of the molecular events in pre-malignant tissue that underlie the progression to malignancy, and (3) to combine data based ... |
|
| Acute Lung Injury Following Smoke Inhalation: Predictive Value of Sputum Biomarkers and Time Course of Lung Inflammation |
MAY 2004 |
12 pages |
| Authors:
Jefferey L. Burgess; ARIZONA UNIV TUCSON
|
| The role of lung inflammatory mediators in the development of lung injury following smoke inhalation is unknown. Objectives: To evaluate the predictive value and role of inflammatory mediators in acute lung injury following smoke inhalation. Specific aims: 1) Determine the predictive value of initial inflammatory markers in bronchial secretions of smoke inhalation victims for subsequent lung injury. 2) Measure longitudinal changes in inflammatory mediators in smoke inhalation victims. Study design: ... |
|
| Mechanistic Studies Investigating the Role of Organophosphate Insecticide Exposure in the Development and Exacerbation of Asthma |
APR 2004 |
21 pages |
| Authors:
Ernst W. Spannhake; JOHNS HOPKINS UNIV BALTIMORE MD
|
| This grant proposes to determine whether organophosphate insecticides act upon the cholinergic system in the lungs increasing cholinergic neurotransmission and causing airway hyperresponsiveness, which is characteristic of asthma. Guinea pigs were either treated acutely with a high dose or chronically (7 days) with a low does of the organophosphate chlorpyrifos sc. Electrical stimulation of the vagus nerves caused frequency-dependent bronchoconstriction that was significantly potentiated in animals treated with chlorpyrifos. M2 ... |
|
| Acute Lung Injury Following Smoke Inhalation: Predictive Value of Sputum Biomarkers and Time Course of Lung Injury |
MAY 2003 |
16 pages |
| Authors:
Jeffrey L. Burgess; ARIZONA UNIV TUCSON
|
| Background: The role of lung inflammatory mediators in the development of lung injury following smoke inhalation is unknown. Objectives: To evaluate the predictive value and role of inflammatory mediators in acute lung injury following smoke inhalation. |
|
| 99HRT Dehydration and Asthma |
MAY 2003 |
13 pages |
| Authors:
Frank Cerny; Paula Maxwell; STATE UNIV OF NEW YORK AT BUFFALO AMHERST RESEARCH FOUNDATION
|
| At least part of the reason for airway narrowing with exercise is due to the exercise-related loss of fluid from the airways. We performed a series of studies to determine if whole body dehydration would affect this response in people known to have asthma. In the first study we tested subjects lung function before and after exercise while fully hydrated and while dehydrated. In those known to have asthma dehydration ... |
|
| Mechanistic Studies Investigating the Role of Organophosphate Insecticide Exposure in the Development and Exacerbation of Asthma |
APR 2003 |
13 pages |
| Authors:
Allison D. Fryer; JOHNS HOPKINS UNIV BALTIMORE MD
|
| This grant proposes to determine whether organophosphate insecticides act upon the cholinergic system in the lungs increasing cholinerqic neurotransmission and causing airway hyperresponsiveness, which is characteristic of asthma. Guinea pigs were either treated acutely with a high dose or chronically (7 days) with a low dose of the organophosphate,chlorpyrifos sc. Electrical stimulation of the vagus nerves caused frequency-dependent bronchoconstriction that was significantly potentiated in animals treated with chlorpyrifos. M2 muscarinic ... |
|
| Prostate Cancer Mortality in Puerto Rican Men: The Effect of Body Habitus and Physical Activity |
FEB 2003 |
47 pages |
| Authors:
Carlos J. Crespo; STATE UNIV OF NEW YORK AT BUFFALO AMHERST
|
| Prostate cancer kills more Puerto Rican men than cancers of the lung, trachea and bronchus. Physical activity has an inconsistent relationship with prostate cancer. It is not clear what the relationship between body habitus and physical activity is among non-Whites population. The underlying hypothesis of this epidemiological research is that excess body adiposity and sedentary lifestyles are independent risk factors for prostate cancer mortality in Puerto Rican men. The specific ... |
|
| Detection of Mitochondrial DNA Mutations in Mammary Epithelial Cells in Nipple Aspirate Fluid |
SEP 2002 |
7 pages |
| Authors:
Bassem R. Haddad; GEORGETOWN UNIV WASHINGTON DC
|
| Because optimal methods have not been established for screening and early detection of breast cancer in premenopausal women, there is an urgent need for a variety of new approaches that can augment mammographic screening. We propose to study a new approach to early detection, based on mitochondrial DNA (mtDNA) mutation analysis of mammary epithelial cells shed into nipple aspirate fluid (NAF) and the Ductal Lavage (DL) fluid. The ability to ... |
|
| Development of a Computer-Aided Diagnostic System for the Detection of Lung Cancer in Helical CT |
DEC 2001 |
53 pages |
| Authors:
Shih-Chung Ben Lo; GEORGETOWN UNIV WASHINGTON DC MEDICAL CENTER
|
| For a long time, lung cancer has been the leading cause of cancer death. Clinical evidences suggest that early detection of lung cancer can increase the chance of survival for those patients suffering lung cancer. Even patients with pulmonary metastasis, early detection will allow earlier modification of these patients' therapies incorporating treatment of the metastases. Therefore, any method, that can improve the clinical efficacy in detecting lung serious public health ... |
|
| Pharmacologic Agents for the Management of Asthma in Aircrew |
JUN 2001 |
|
| Authors:
G. W. Gray; DEFENCE AND CIVIL INST OF ENVIRONMENTALMEDICINE DOWNSVIEW (ONTARIO)
|
 | Asthma is an inflammatory condition of the airways, producing variable bronchoconstriction. First line therapy is directed at controlling the inflammatory process with agents such as inhaled steroids, nedocromil, and the newer leukotriene inhibitor drugs. In severe cases, systemic steroids or other immunosuppressive therapies may be required for suppression of inflammation. |
|
| Nuclear Factor-kappa B is Not Up-Regulated in Rat Pulmonary Tissue Following Sulfur Mustard (HD) Exposure |
MAY 2001 |
16 pages |
| Authors:
Michele M. Danne; James A. Blank; Kristi L. Buxton; Nancy A. Niemuth; Alfred M. Sciuto; ARMY MEDICAL RESEARCH INST OF CHEMICAL DEFENSE ABERDEEN PROVING GROUND MD
|
| Vesicants, such as sulfur mustard (HD), pose an insidious threat to the respiratory tract. Exposure causes acute lung injury characteristic of an inflammatory response. Nuclear Factor-KAPPA B (NF- square B) is a redox sensitive transcription factor important in regulating genes involved in the inflammation. This study evaluated levels of NF-square B following exposure to HD. Male rats were euthanized at 3, 6, or 24 hr following intravenous HD or isopropanol ... |
|
| Modeling the Biodynamical Response of the Human Thorax with Body Armor from a Bullet Impact |
01-Mar-2001 |
93 pages |
| Authors:
John A Lobuono; Young W Kwon; NAVAL POSTGRADUATE SCHOOL MONTEREY CA DEPT OF MECHANICAL ENGINEERING
|
| The purpose of this research is to develop a finite element model of the human thorax with a protective body armor system so that the model adequately determines the biodynamical response of the thorax to a projectile impact. The biodynamical response of the human thorax is examined under two different scenarios. The first scenario analyzes the biodynamical response of the human thorax with body armor consisting of a Kevlar sheet ... |
|
| Modeling the Biodynamical Response of the Human Thorax With Body Armor From a Bullet Impact |
MAR 2001 |
96 pages |
| Authors:
John A. Lobuono; NAVAL POSTGRADUATE SCHOOL MONTEREY CA
|
| The objective of this study is to develop a finite element model of the human thorax with a protective body armor system so that the model can adequately determine the thorax's biodynamical response from a projectile impact. The finite element model of the human thorax consists of the thoracic skeleton, heart, lungs, major arteries, major veins, trachea, and bronchi. The finite element model of the human thorax is validated by ... |
|
| Airway Reactivity Response to Advanced Composite Material (ACM) combustion Atmospheres: B2-ACM |
MAR 2000 |
83 pages |
| Authors:
Edgar C. Kimmel; James E. Reboulet; David L. Courson; Gregory S. Whitehead; Kenneth R. Still; NAVAL HEALTH RESEARCH CENTER WRIGHT-PATTERSON AFB OH TOXICOLOGY DETACHMENT
|
| Exposure for 30 minutes to diluted smoke from pyrolysis of advanced composite material used in the construction of the B2 bomber (B2-ACM) caused an airway reactivity (AR) response in naive guinea pigs reminiscent of a human asthmatic episode. Animals exposed to diluted smoke from pyrolysis of 5, 10 and 100 grams of B2-ACM showed changes in a number of parameters characterizing ventilation, breathing pattern, and ... |
|
| Physiological Vibration and Resonance of LFS on the Respiratory System |
29 NOV 1999 |
114 pages |
| Authors:
Andrew C. Jackson; TRUSTEES OF BOSTON UNIV MA
|
| Model predictions of the effects of LFS on the human respiratory system suggested that pressures within airways can be greater than pressures applied to the body surface. In the current study, more physiologically and anatomically accurate human and rat lung models were developed to further study the consequences of LFS as well as to infer human lung behavior from measurements made in rats. The human ... |
|
| Modification and Control of Wound Healing in Tracheobronchial Injuries Using Minimally Invasive Surgical Techniques and Biologic Growth Factors-CIC3 |
NOV 1998 |
35 pages |
| Authors:
Jonathan A. Perkins; ALBANY MEDICAL COLL NY
|
| Tracheobronchial injury is associated with significant morbidity and mortality. Morbidity occurs both early and late (i.e. airway stenosis). Current treatment options for post traumatic tracheal lesions include surgical resection or endoscopic repair. Commonly, surgery is necessary after endoscopic management fails from restenosis. However, surgical resection can have a similar outcome. Currently, metallic stents offer an adjunctive treatment in airway reconstruction. These stents have the capability ... |
|
| Acute Inhalation of Explosively Disseminated Carbon Fibers in Rats |
MAY 94 |
111 pages |
| Authors:
Roger J. Hilaski; Jeffrey D. Bergmann; David C. Burnett; William T. Muse Jr.; Sandra A. Thomson; EDGEWOOD RESEARCH DEVELOPMENT AND ENGINEERING CENTER ABERDEEN PROVING GROUND MD
|
| Carbon fibers are lightweight, high tensile strength synthetic strands used commercially and in military applications for aircraft and electromagnetic obscuration. Fibers with respirable diameters 10 micrometers will deposit by interception in the bronchi. Recent XM81 grenade field studies indicated that explosive dissemination produced fibers with diameters <3.0 micrometers and lengths <100 micrometers, making some of the fibrous smoke respirable. Carbon fibers were explosively generated to determine if the resultant aerosol ... |
|
| Use of EPR Spin-Trapping Techniques to Detect Radicals from Rat Lung Lavage Fluid Following Sulfur Mustard Vapor Exposure |
13 MAY 1993 |
10 pages |
| Authors:
D. R. Anderson; J. J. Yourick; C. M. Arroyo; G. D. Young; L. W. Harris; ARMY MEDICAL RESEARCH INST OF CHEMICAL DEFENSE ABERDEEN PROVING GROUND MD
|
| Although well known for skin vesicating properties, pulmonary damage and associated infections account for most of the mortality associated with sulfur mustard (HD). We have employed an in vivo HD vapor exposure model, bronchoalveolar lavage and histopathology in conjunction with electron paramagnetic resonance (EPR) techniques to provide evidence for HD-induced (free radical/lipid peroxidation associated) lung injury. Anesthetized rats were intratracheally intubated and exposed to 0.35 mg HD vapor over 50 ... |
|
| Acute and Chronic Respiratory Lesions Induced by Sulfur Mustard in Guinea Pigs: Role of Tachykinins |
13 MAY 1993 |
11 pages |
| Authors:
J. H. Calvet; G. Trouiller; A. Harf; ARMY MEDICAL RESEARCH INST OF CHEMICAL DEFENSE ABERDEEN PROVING GROUND MD
|
| We investigated in anesthetized guinea pigs the involvement of tachykinins in respiratory alterations after an airway intoxication by sulfur mustard (SM). Early lesions were evaluated after 5h. Respiratory system resistance (R) and compliance were measured by the occlusion method and airway microvascular permeability by measuring the Evans Blue dye concentration in the trachea and main bronchi. Two groups of animals were studied treated with capsaicin (which induces a tachykinin depletion) ... |
|
| Sulfur Mustard Inhalation Induced Respiratory Lesions in Guinea Pigs: Physiological, Biochemical, and Histological Study |
13 MAY 1993 |
8 pages |
| Authors:
N. Allon; E. Gilat; A. Amir; E. Fishbine; H. Liani; ARMY MEDICAL RESEARCH INST OF CHEMICAL DEFENSE ABERDEEN PROVING GROUND MD
|
| Inhalation exposure to sulfur mustard (SM) vapor causes long term damage to the respiratory system. The lesions were characterized by specific physiological, biochemical and histopathological methods. Awake 128 guinea-pigs (GP) were exposed for 10 min to SM (1200-1700 microns x min/1). Respiratory parameters were monitored per animal before, during and after the exposure using plethysmograph's. Biochemical and histological evaluations were performed at different time intervals for up to 7 days ... |
|
| Comparison of Endobronchial and Tracheal Insufflation for Acute Respiratory Distress |
14 DEC 91 |
|
| Authors:
Colin F. Mackenzie; MARYLAND UNIV BALTIMORE SCHOOL OF MEDICINE
|
| We studied tracheal insufflation of O2 (TRIO) or air (TRIA) and endobronchial insufflation of O2 (EIO) or air (EI), and other potential field ventilation techniques that were simple, lightweight, and required limited gas supplies. All studies were carried out in anesthetized dogs instrumented with arterial and pulmonary artery catheters for measurement of cardiac output, vascular pressure, and sampling of blood. Blood pressures (BP), electrocardiograms, arterial and venous O2 saturation, and ... |
|
| The Toxic Effect of Soman on the Respiratory System |
MAR 91 |
|
| Authors:
Pal Aas; Frode Fonnum; Rolf Gaustad; Per Walday; NORWEGIAN DEFENCE RESEARCH ESTABLISHMENT KJELLER
|
| The in vitro exposure of rat and guinea pig bronchial smooth muscle to the cholinesterase inhibitor soman (o-(1,2,2-trimethylpropyl) methylphosphonofluoridate), in concentrations from 10 nM-1 muM, potentiated the rapid and concentration-dependent increase in the response of acetylcholine (ACh). The soman concentration of 10 nM corresponded to a 65 and 80-100% inhibition of acetylcholinesterase (AChE) in rat and guinea pig bronchi respectively. The apparent affinity to ACh increased without any change in ... |
|
| The Toxic Effect of Soman on the Respiratory System |
31 JAN 91 |
|
| Authors:
Pal Aas; Frode Fonnum; Rolf Gaustad; Per Walday; NORWEGIAN DEFENCE RESEARCH ESTABLISHMENT KJELLER DIV FOR ENVIRONMENTAL TOXICO LOGY
|
| The in vitro exposure of rat and guinea pig bronchial smooth muscle to the cholinesterase inhibitor soman (0-(1,2,2-trimethylpropyl) methylphosphonofluoridate), in concentrations from 10 nM 1 micro, potentiated the rapid and concentration dependent increase in the response to acetylcholine (ACh). The soman concentration of 10 nM corresponded to a 65 and 80-100% inhibition of acetylcholinesterase (AChE) in rat and guinea pig bronchi, respectively. The apparent affinity to ACh increased without any ... |
|
| The Morphology of Smoke Inhalation Injury in Sheep, |
1991 |
10 pages |
| Authors:
Gene B. Hubbard; Paulette C. Langlinais; Takeshi Shimazu; Carlin V. Okerberg; Arthur D. Mason; ARMY INST OF SURGICAL RESEARCH FORT SAMHOUSTON TX
|
| Pulmonary injury resulting from inhalation of chemical and particulate products of incomplete combustion is one of the principal determinants of mortality following burn injury. In this study, the histopathology of inhalation injury was examined in sheep. Mild, moderate, or severe smoke injury was produced in anesthetized sheep by insufflation with various doses of ambient temperature smoke, generated by burning polyethylene, wood pulp, and nonwoven cellulose pads. A total of 64 ... |
|
| Comparison of Endobronchial and Tracheal Insufflation for Acute Respiratory Distress |
14 MAR 90 |
77 pages |
| Authors:
Colin F. Mackenzie; MARYLAND UNIV BALTIMORE DEPT OF ANESTHESIOLOGY
|
| Prototype airway catheters were developed 1) to allow ventilation with a continuous flow of air into the mainstream bronchi (EI) and 2) to oxygenate by flowing O2 into the trachea (TRIO). Minimum flows (Vmin) using EI and TRIO were 0.2-0.3 L/kg/min air and 90 ml/min O2, respectively. Ventilation for up to 4 hours with Vmin EI was carried out in anesthetized dogs and physiological parameters were measured serially during apnea ... |
|
| The Toxic Effect of Soman on the Respiratory System |
30 JUN 88 |
|
| Authors:
Pal Aas; Frode Fonnum; NORWEGIAN DEFENCE RESEARCH ESTABLISHMENT KJELLER
|
| The in vitro exposure of rat and guinea pig bronchial smooth muscle to the cholinesterase inhibitor soman 0-(1,2,2-trimethylpropyl)methylphos- phonofluoridate), in concentrations from 10 nM-1 micromole, potentiated the rapid and concentration-dependent increase in the response to acetylcholine (ACh). The soman concentration corresponded to a 65 and 80-100% inhibition of acetylcholinesterase (AChE) in rat and guinea pig bronchi, respectively. The apparent affinity to ACh increased without any change in intrinsic activity in ... |
|
| Effects of Beta-2 Adrenergic Agonists on Contracture of Airway Smooth Muscle Induced by Inhibition of Cholinesterase |
APR 88 |
|
| Authors:
Margaret G. Filbert; Michael Adler; David H. Moore; G. K. Adams III; ARMY MEDICAL RESEARCH INST OF CHEMICAL DEFENSE ABERDEEN PROVING GROUND MD
|
| The effect of beta-2 adrenoreceptor agonists on nerve agent-induced bronchoconstriction has been investigated in isolated canine trachealis and in human bronchi. Isoproterenol and salbutamol elicited relaxation of soman-induced contractures in canine tracheal smooth muscle. The relaxation was transitory. Return to the previous level of contracture occurred within 10 min. Human bronchi exposed to DFP developed large contractures similar to those seen in canine trachealis exposed to soman. Isoproterenol relaxed both ... |
|
| Toxicity of Tobacco-Related Aldehydes in Cultured Human Bronchial Epithelial Cells |
MAY 1985 |
11 pages |
| Authors:
Roland C. Grafstrom; J. C. Wiley; K. Sundqvist; C. C. Harris; NATIONAL CANCER INST BETHESDA MD
|
| One approach to the problem of extrapolating experimental animal data to humans is the development of in vitro model systems using human tissues and cells. Among more than 6,000 identified components in tobacco smoke, several reactive and volatile aldehydes are found in the gaseous phase and are of interest because of their potential carcinogenicity in the human respiratory tract. In particular, acetaldehyde, acrolein, and formaldehyde are present in amounts ranging ... |
|
| Assessment of Airway Epithelial Ion Transport Functions in Patients, in Excised Tissues and in Cultured Cells, |
MAY 1985 |
|
| Authors:
M. J. Stutts; M. R. Knowles; J. R. Yankaskas; V. Ranga; P. A. Bromberg; NORTH CAROLINA UNIV AT CHAPEL HILL
|
| A great deal of information about function of the epithelium that lines the respiratory tract has accrued in recent years. Because this tissue is so exposed and its functions are so important in the defense of the lung against infection, much of this research has centered on the role of pollutant induced damage to epithelial function in environmental lung disease. Such research is difficult to carry out in normal human ... |
|
| International Montreux Conference of Chronopharmacology |
FEB 85 |
|
| Authors:
M. H. Smolensky; TEXAS UNIV AT HOUSTON SCHOOL OF PUBLIC HEALTH
|
| The report which follows is divided into the following three sections: (1) overview summary of the First Montreux International Congress of Chronopharmacology, (2) listing of the participants supported by this contract and (3) 5 copies of the proceedings as stipulated by the contract. Papers delivered at the First Montreux Conference dealt with 8 major themes as outlined below: Neurobiology; Antihistamines and Bronchodilators; Anticancerous Medications; Statistics, Methods and Instrumentation, including Pumps; ... |
|
| A Model of Inhaled Gas and Vapor Transport in the Human Lung |
85 |
|
| Authors:
M. L. Shelley; AIR FORCE INST OF TECH WRIGHT-PATTERSON AFB OH
|
| The transport of inhaled gas or vapor in the human lung is theoretically modeled to determine the fraction of inhaled gas or vapor absorbed through the bronchial walls in the conductive zone and the fraction entering alveolated space and undergoing blood/gas exchange. An iterative-analytical approaches used, rather than a numerical one, to generate a large amount of data over a wide range of gas or vapor solubilities and diffusivities. The ... |
|
| Modulation of the Cholinergic Mechanisms in the Bronchial Smooth Muscle |
JUN 1984 |
|
| Authors:
P. Aas; NORWEGIAN DEFENCE RESEARCH ESTABLISHMENT KJELLER
|
| In the present work it was shown that cholinergic nerves to the bronchial smooth muscle were modulated by several independent mechanisms. The release of acetylcholine (Ach) was regulated by presynaptic muscarinic receptors and by adenosine. The presynaptic regulation of release was shown to operate in addition to the postsynaptic stimulation of the bronchial smooth muscle. The function of the cholinergic nervous system in bronchi and lung is depending on the ... |
|
| Application of Animal Models for Immediate and Delayed Pulmonary Hypersensitivity: Characteristics of Delayed Reactions to Tuberculin Protein, |
AUG 1983 |
|
| Authors:
Meryl H. Karol; Cathleen Magreni; Judith Stadler; PITTSBURGH UNIV PA DEPT OF INDUSTRIAL ENVIRONMENTAL HEALTH SCIENCES
|
| Delayed-onset pulmonary reactions have been reported following exposure to a wide variety of environmental and industrial allergens. Reactions are characterized by onset more than one hour after exposure. Frequently reactions occur from 4-24 hours following exposure. Pathogenesis of such reactions remains unclear. In the animal model described here, repeated inhalation challenge of guinea pigs with PPD aerosol resulted in a pattern of respiratory response different from that seen upon first ... |
|
| Treatment of Inhalation Injury, |
21 JAN 1983 |
7 pages |
| Authors:
J. Guilbaud; ARMY INST OF SURGICAL RESEARCH FORT SAM HOUSTON TX
|
| The expression 'inhalation injury', in English terminology, includes conditions as different as those due to soot inhalation, barotrauma lesions or respiratory burns. Our point of view is that 'inhalation injury' represents only one instance of a more general condition called 'Primary Respiratory Lesions.' This expression 'Primary Respiratory Lesions' includes all the direct pulmonary lesions induced by the causal agent itself at the time of the insult. These direct lesions include: ... |
|
| Formation of Reactive Naphthalene Metabolites by Target versus Non- Target Tissue Microsomes: Methods for the Separation of Three Glutathione Adducts |
19 NOV 1982 |
|
| Authors:
Gregory Smart; Alan R. Buckpitt; CALIFORNIA UNIV IRVINE
|
|
| Comparative Biochemistry and Metabolism. Part II. Naphthalene Lung Toxicity |
AUG 1982 |
43 pages |
| Authors:
Alan R. Buckpitt; CALIFORNIA UNIV IRVINE DEPT OF COMMUNITY AND ENVIRONMENTAL MEDICINE
|
| Earlier studies have shown that cytochrome P-450 dependent metabolism of the volatile aromatic hydrocarbon, naphthalene, results in dose dependent bronchiolar necrosis in mice and in the formation of reactive metabolites which deplete cellular glutathione and become bound covalently to tissue macromolecules. Pretreatments which altered the severity of bronchiolar necrosis altered the extent of covalent binding in the lung. However, the overall levels of covalently bound metabolites in liver and kidney ... |
|
| The Role of Respiratory Heat Exchange in the Production of Exercise-Induced Asthma, |
APR 1978 |
|
| Authors:
E. Chandler Deal Jr.; E. R. McFadden Jr.; R. H. Ingram Jr.; Richard H. Strauss; James J. Jaeger; ARMY RESEARCH INST OF ENVIRONMENTAL MEDICINE NATICK MASS
|
| By having our subjects inhale dry air at various temperatures ranging from subzero to 80 C in a random fashion, we have tested the hypothesis that it is the total heat flux in the tracheobronchial tree during exercise that determines the degree of post-exertional obstruction that develops in asthma. Our purpose in this was to determine if heat could be transferred from the air to the mucosa so as to ... |
|
| Pulmonary Manifestations in Filariasis. |
15 JUL 1977 |
|
| Authors:
Hassan Hosny Youssef; AIN SHAMS UNIV CAIRO (EGYPT)
|
| 12.87% OF MALES AND 9.66% OF FEMALES IN THE VILLAGE OF Manshat E1 Bakary were positive for microfilaraemia using the 20 mm. blood film method. By the newer concentration methods for the percentages would have been higher. Even the lower percentages indicate the endemicity of filariasis in this village. In a study to determine the clinical manifestations of filariasis, bilharziasis ascariasis, oxysuriasis and malaria were common concurrent endemic diseases. In ... |
|
| Present Concepts in Internal Medicine. Pulmonary Rehabilitation, 1975, |
JUL 1975 |
|
| Authors:
Edward E. Mays; Lottie B. Applewhite; Ronald E. Burnam; Stephen M. Lindsey; Donald D. Smith; LETTERMAN ARMY MEDICAL CENTER SAN FRANCISCO CALIF
|
| The symposium consists of nine articles on the present concepts of pulmonary rehabilitation. Beginning with an article on humidification and nebulization therapy, it continues with articles on the use of antibiotic chemoprophylaxis in chronic obstructive pulmonary disease (COPD), non-aerololized bronchodilators, intermittent positive pressure breathing (a review of the literature), corticosteroids, exercise and physiotherapy, surgical treatment for bullous emphysema, and oxygen therapy. The symposium concludes with a summary of the positive ... |
|
| Geography and the Properties of Surfaces. A Computer Program for Mixed Hexagonal Hierarchies. |
15 JUN 1975 |
|
| Authors:
Rachel F. Thurston; Michael J. Woldenberg; David Barer; HARVARD UNIV CAMBRIDGE MASS LAB FOR COMPUTER GRAPHICS AND SPATIAL ANALYSIS
|
| This paper presents an improved computerized model for generating hierarchies of branching in inorganic systems such as rivers and Lichtenberg figures, and organic branching systems such as blood vessels, air ways, bile ducts and Purkinje cells. In addition the model predicts hierarchies of market areas in a central place system. The model generates all possible hierarchies based on the division of an area into successively smaller hexagons with area ratios ... |
|
| The Functional Study of the Lungs During Pollen Bronchial Asthma, |
20 NOV 1974 |
|
| Authors:
T. A. Chervinskaya; Yu. A. Samushiya; FOREIGN TECHNOLOGY DIV WRIGHT-PATTERSON AFB OHIO
|
| The article is devoted to the study of the function of the lungs in pollen bronchial asthma. The authors used Tiffeneau's test, determined compliance test and applied pneumotachometry. A total of 30 patients with pollen asthma with an allergy to pollen of cereal grass, trees and wormwood were examined. Investigations were made during the period of remission and post-vaccinal inhalation test with a specific pollen allergen. Results of investigations showed ... |
|
| Features of the Diagnosis and Clinical Treatment of Noninfectious Allergic Bronchial Asthma, |
15 AUG 1974 |
|
| Authors:
Ya. M. Zonis; FOREIGN TECHNOLOGY DIV WRIGHT-PATTERSON AFB OHIO
|
| Three types of relationships between infectious processes in the lungs and infectious-allergic bronchial asthma were observed: A process in the bronchopulmonary apparatus activates sensitization of the organism by noninfectious allergens, mainly as the result of nonspecific injury to the mucous membranes of the bronchi, promoting penetration of the allergens into the organism of the patients; Acute nonspecific disease of the respiratory tract provokes the appearance of bronchial asthma in individuals ... |
|
| Die Anwendung des Diureticums Lasix bei Druckstossverietzungen (The Use of the Diuretic Lasix in Blast Injury), |
1970 |
|
| Authors:
O. Wuensche; G. Scheele; DEUTSCHE FORSCHUNGS- UND VERSUCHSANSTALT FUER LUFT- UND RAUMFAHRT E V BONN-BAD GODESBERG (WEST GERMANY)
|
| Aus den vorliegenden Untersuchungsergebnissen geht hervor, dass bei Zwergschweinen nach Schadigung durch Druckwellenstoss die Uberdruckbehandlung in Verbindung mit diuretischen Massnahmen, wie mit der Verabriechung von ,Lasix'(Fursemide), ohne Zweifel als eine mogliche Therapieform ihre Bedeutung hat. Der kritische Vergleich von Therapie- und Kontrolltieren in Gruppen, die 21--35 Tage und 36--60 Tage uberlebt haben, hat ergeben, dass bei den behandelten Zwergschweinen nach an sich schneller Resorption der Blutungen, die reparativen Vorgange in ... |
|
| PROBLEMS RELATED TO IMMUNIZATION WITH LIQUID VACCINE AEROSOLS |
24 NOV 1967 |
20 pages |
| Authors:
I. I. Terskikh; A. I. Danilov; ARMY BIOLOGICAL LABS FREDERICK MD
|
|
| AIR POLUTION ASTHMA IN OSAKA, JAPAN. |
DEC 1966 |
|
| Authors:
Ovid B. Bush; YODOGAWA CHRISTIAN HOSPITAL OSAKA (JAPAN)
|
| During the past year there has been a marked decrease in the number of cases of bronchitis seen by the Armed Forces in the Kanto Plain area as well as by the civilian hospital in Osaka. This finding may lend support to the conception of immunity conferred by respiratory illnesses. During the past year 64 of chronic bronchitis, acute bronchitis, or bronchial asthma were studied. Seven cases did not cooperate ... |
|
| STUDIES OF RESPIRATORY DISEASES DUE TO AIR POLLUTION IN THE TOKYO-YOKOHAMA AREA |
DEC 1966 |
37 pages |
| Authors:
Tatsushi Ishizaki; TOKYO UNIV (JAPAN) DEPT OF PHYSICAL THERAPY AND MEDICINE
|
| Fifteen normal subjects and eighteen asthmatic patients were tested by spirography and body plethysmography, and changes of airway resistance before and after inhalation of sulfur dioxide in three and six minutes were followed and analysed. The mean of variation of airway resistance was 1.85 in normal subjects and 2.03 in asthmatic patients, and S.D. of variation of that was plus or minus 0.2 in formar and plus or minus .67 ... |
|
| EARLIEST ATTEMPTS AT SURGICAL TREATMENT OF BRONCHIAL ASTHMA WITH THE METHOD OF PULMONARY AUTOGRAFTS, |
04 NOV 1966 |
|
| Authors:
E. N. Meshalkin; V. S. Sergievskii; G. L. Feofilov; G. A. Savinskii; A. V. Baeva; NAVAL MEDICAL SCHOOL BETHESDA MD TRANSLATION SERVICE
|
| The proposed surgical interventions for bronchial asthma are focused in denervation of the lungs. However, denervation after such operations is partial and cannot completely break the arc of pathological reflex. Apparently, this can only be achieved with the method of lung autografts. Experiments on dogs showed that unilateral and bilateral autografts of lungs are technically feasible, do not essentially reflect on vital activities of the organism, and involve no marked ... |
|
Reports by Keyword(s)
BRONCHI
