| Operation Brain Trauma Therapy |
Oct 2012 |
59 pages |
| Authors:
Patrick M Kochanek; PITTSBURGH UNIV PA
|
 | Operation brain trauma therapy (OBTT) is a multicenter, pre-clinical, drug screening and brain injury biomarker development consortium for TBI. OBTT includes investigators at the Safar Center (University of Pittsburgh), the University of Miami, WRAIR, Virginia Commonwealth University, and Banyan Biomarkers. Three rodent models (controlled cortical impact, parasagittal fluid percussion, and penetrating ballistic-like brain injury) are used for drug screening with the most promising candidates tested in a micropig model. We ... |
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| Early Detection of Ovarian Cancer by Molecular Targeted Ultrasound Imaging Together with Serum Markers of Tumor-Associated Nuclear Change and Angiogenesis |
Oct 2012 |
13 pages |
| Authors:
Animesh Barua; RUSH UNIV MEDICAL CENTER CHICAGO IL
|
| One of the most significant barriers to establishing an early ovarian cancer (OVCA) detection test is the difficulty of identifying patients with early stage OVCA. In earlier approaches to develop an early detection test for OVCA, using serum levels of CA- 125, traditional transvaginal ultrasound and their combination did not improve the detection of OVCA remarkably. The limitation of CA-125 is that it is non-specific in detecting OVCA at the ... |
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| Vitamin D and Related Genes, Race, and Prostate Cancer Aggressiveness |
Oct 2012 |
6 pages |
| Authors:
Susan Steck; SOUTH CAROLINA RESEARCH INST COLUMBIA
|
| The overall goal of the study is to examine whether altered vitamin D status (as measured by serum metabolites and by functional polymorphisms with genes related to vitamin D transport, metabolism and activity) is associated with increased risk of aggressive prostate cancer, and may explain some of the racial disparity seen in aggressive prostate cancer. The project activities, as outlined in the Statement of Work Tasks and Milestones, are running ... |
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| Development of Technologies for Early Detection and Stratification of Breast Cancer |
Oct 2012 |
38 pages |
| Authors:
David R Walt; Daniel Chiu; Charlotte Kuperwasser; Gail Sonenshein; Rachel Buchsbaum; TUFTS UNIV MEDFORD MA
|
| The overall goal of this work is to develop ultra-sensitive detection techniques to identify a panel of new biomarkers and indicators with diagnostic and predictive value in breast cancer. During year 1, we identified candidate breast cancer biomarkers and developed ultra-sensitive assays for several of them. Two different miRNA single molecule assay approaches have also been investigated and both showed promise for achieving similar ultrasensitive data using miRNA as targets. ... |
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| Improving the Efficiency and Efficacy of Glibenclamide in Limiting Progressive Hemorrhagic Necrosis Following Traumatic Spinal Cord Injury |
Oct 2012 |
5 pages |
| Authors:
J M Simard; BALTIMORE UNIV MD
|
| Preclinical work has demonstrated that glibenclamide administration improves outcomes in rat models of spinal cord injury, with the principal mechanism of action being amelioration of post-traumatic hemorrhagic necrosis (PHN). We hypothesize that some but not all patients with spinal cord injury, principally those with incomplete lesions, will respond to glibenclamide therapy. Our goal is identify early markers of injury that can be used to predict which patients may benefit from ... |
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| Biomarkers of Renal Tumor Burden and Progression in TSC |
Sep 2012 |
10 pages |
| Authors:
Elahna Paul; MASSACHUSETTS GENERAL HOSPITAL BOSTON
|
| Renal lesions occur commonly in people with TSC and can cause significant morbidity and mortality [1]. Although most solid renal lesions of TSC are benign angiomyolipoma (AML), some are in fact cancerous. Moreover, rapidly growing AMLs can be life threatening when abnormal blood vessels rupture [2]. Based on the hypothesis that renal tumor growth is associated with measurable changes in urine composition and on the knowledge that angiogenesis is essential ... |
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| Proteomics of Peripheral Leukocytes in Patients with Elevated Serum Levels of PSA |
Sep 2012 |
10 pages |
| Authors:
Martin A Steffen; Agnes Bergerat; BOSTON UNIV MA
|
| During this third year of research, we have analyzed protein abundance levels of CD4+ T-lymphocytes and demonstrated that in accordance with our original hypothesis, we are able to discriminate between prostate cancer and benign prostate disease in patients with an elevated PSA level. A manuscript detailing these results is being prepared. Additionally, we explored the proteomes of lymphocytes from mice, and have found that the procedures involved with sample procurement ... |
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| Glyco-Immune Diagnostic Signatures and Therapeutic Targets of Mesothelioma |
Jul 2012 |
11 pages |
| Authors:
Harvey Pass; NEW YORK UNIV NY SCHOOL OF MEDICINE
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| This project is funded in order to investigate immunoprofiles of serum anti-glycan antibodies recognizing Mesothelioma-derived aberrant glycans in human subjects and in animal models of Mesothelioma. This is accomplished using a one of a kind printed glycan array which has been developed by us at the New York University School of Medicine (NYU SoM) and has now been expanded by addition of 177 novel glycan probes, many of which are ... |
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| Glyco-Immune Diagnostic Signatures and Therapeutic Targets of Mesothelioma |
Jul 2012 |
10 pages |
| Authors:
Margaret E Huflejt; NEW YORK UNIV NY
|
| This project is funded in order to investigate immunoprofiles of serum anti-glycan antibodies recognizing Mesothelioma-derived aberrant glycans in human subjects and in animal models of Mesothelioma. This is accomplished using a one of a kind printed glycan array which has been developed by us at the New York University School of Medicine (NYU SoM) and has now been expanded by addition of 177 novel glycan probes, many of which are ... |
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| The Role of Central Metabolism in Prostate Cancer Progression |
Jul 2012 |
5 pages |
| Authors:
Mu Wang; INDIANA UNIV INDIANAPOLIS
|
| As part of a three-PI team for this synergy grant, our goal is to: 1. To identify differentially expressed proteins and phosphoproteins in prostate cancer cells from patients on high -3 and control diets. 2. To examine the effects of the -3 diet on apoptosis and cell proliferation. 3. To assess the effect of the -3 rich diet on prostate tumors as well as PUFA pathways by measuring absolute and ... |
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| Prostate Cancer Pathology Resource Network |
Jul 2012 |
32 pages |
| Authors:
Bruce Trock; JOHNS HOPKINS UNIV BALTIMORE MD
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| The Prostate Cancer Pathology Resource Network (which has since been renamed the Prostate Cancer Biorepository Network or PCBN) is a collaboration between the Johns Hopkins School of Medicine (JHU) and the New York University School of Medicine (NYU). The goal of the PCBN is to develop a biorepository with high quality, well annotated specimens that can be used by prostate cancer researchers. The specimens in the PCBN include prostatectomy tissues ... |
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| Biochemical and Genetic Markers in Aggressiveness and Recurrence of Prostate Cancer: Race-Specific Links to Inflammation and Insulin Resistance |
Jul 2012 |
15 pages |
| Authors:
Izabela Podgorski; WAYNE STATE UNIV DETROIT MI
|
| This proposal is driven by hypothesis that certain biological factors associated with metabolic syndrome may play a role in racial differences in prostate cancer (PCa) aggressiveness and prognosis. This is the first study to include large numbers of African American men in an evaluation of metabolic syndrome and the first to study the association between metabolic syndrome and PCa recurrence by race. Our hypothesis is being tested in 2 Aims: ... |
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| Detection of Orexin A Neuropeptide in Biological Fluids Using a Zinc Oxide Field Effect Transistor |
Jun 2012 |
39 pages |
| Authors:
Joshua Hagen; Wanda Lyon; Yaroslav Chushak; Morley Stone; Nancy Kelley-Loughnane; Melanie Tomczak; Rajesh Naik; AIR FORCE RESEARCH LAB WRIGHT-PATTERSON AFB OH MATERIALS AND MANUFACTURING DIRECTORATE
|
| Biomarkers which are indicative of acute physiological and emotional states are studied in a number of different areas in cognitive neuroscience. Currently, many cognitive studies are conducted based on programmed tasks followed by timed biofluid sampling, central lab processing, and followed by data analysis. In this work, we present a sensor platform capable of real-time biomarker detection specific for detecting neuropeptide orexin A, found in blood and saliva and known ... |
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| Granulopoietic Growth Factor Secretion in Ovarian Carcinoma as a Mechanism for the Emergence of Immune Suppressive Myeloid Subsets |
Jun 2012 |
28 pages |
| Authors:
Scott Abrams; HEALTH RESEARCH INC BUFFALO NY
|
| A major problem facing effective ovarian cancer immunotherapy is the capacity of malignant populations to inhibit immune activation or evade destruction. Among prominent mechanisms thought to impede the anticancer response is the accumulation of pro-tumorigenic myeloid populations, termed myeloid-derived suppressor cells (MDSC). However, there is a fundamental gap in knowledge regarding the exact mechanisms that drive their development or accumulation. To that end, we originally hypothesized that the overproduction of ... |
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| Health Risk Assessment of Women in Submarines (Phase III): Two Generation Developmental and Reproductive Safety Evaluation of Major Submarine Atmosphere Components (CO, CO2, and O2) in Rats (Rattus norvegicus) |
31 May 2012 |
133 pages |
| Authors:
Daniel J Hardt; R A James; Jr Gut Chester P; Shawn M McInturf; Michael L Gargas; NAVAL MEDICAL RESEARCH UNIT DAYTON WRIGHT-PATTERSON AFB OH
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| This study evaluated general, reproductive and developmental effects on male and female rats exposed to mixed atmospheres of three critical submarine air components (CO, CO2, and O2) at concentrations approximating the existing submarine standards for continuous exposure limits (CELs) and emergency exposure limits (24-hour EEL and 1-hour EEL). This report describes a 90-day, two-generation evaluation of the general health and reproductive effects in male and female rats exposed to atmospheres ... |
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| A Novel Method for Inducing Therapeutic Hypothermia in a Swine Model of Blast-Induced Traumatic Brain Injury with Associated Hemorrhagic Shock |
May 2012 |
15 pages |
| Authors:
Matthew M Kumar; MAYO CLINIC ROCHESTER MN
|
| The purpose of this study was to determine the effect of rapidly induced hypothermia on neurological outcomes following fluid percussion injury in swine. A second objective was to test the safety and efficacy of inducing hypothermia through augmented heat extraction from the lungs using heliox and perfluorocarbon mist ventilation. The hypothermia device was built and bench tested. Brain temperatures in all hypothermic animals reached target (32-33 C) within 60 minutes. ... |
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| Vaccine Immunotherapy for Prostate Cancer |
May 2012 |
12 pages |
| Authors:
David Lubaroff; IOWA UNIV IOWA CITY
|
| The purpose of the research supported by this award is to conduct a Phase II clinical trial (study) of an adenovirus/PSA (Ad/PSA) vaccine for the treatment of prostate cancer. Two protocols have been used in the trial: #1 - Phase II study of Adenovirus/PSA vaccine in men with recurrent prostate cancer after local therapy; and #2 - Phase II study of Adenovirus/PSA vaccine in men with hormone refractory prostate cancer. ... |
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| Roles of SGK Isoform Signaling in Breast Cancer Migration and Invasion |
Apr 2012 |
13 pages |
| Authors:
Jessica Gasser; HARVARD UNIV BOSTON MA
|
| My experiments indicate that Serum and Glucocorticoid regulated Kinase (SGK) proteins facilitate breast cancer invasive migration, a critical step for ultimate cancer metastasis to other organs. The activation of SGK during cellular stress conditions, such as low oxygen found within a tumor, makes this data increasingly imperative for therapeutics. The research shown here demonstrates SGK loss in highly mestatic breast cancer cell lines causes an invasive migration defect. Conversely, the ... |
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| Old Receptors, New Treatment Strategies for Breast Cancer |
Apr 2012 |
48 pages |
| Authors:
Wei Xu; WISCONSIN UNIV MADISON
|
| We have made considerable progress towards each project proposed in the original grant. For Aim 1, we have developed TRFRET assays that can be adapted for high throughput screening to identify chemical activator of CARM1 for breast cancer differentiation therapy. For Aim 2, we have developed isogenic MDA-mb-468 cell line inducibly express either ER or ER . These cell lines have been validated to form xenograft tumors in nude mice. ... |
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| Functional Characteristics of Tumor Associated Protein Spot14 and Interacting Proteins in Mouse Mammary Epithelial and Breast Cancer Cell Lines |
Mar 2012 |
12 pages |
| Authors:
Michael C Rudolph; COLORADO UNIV HEALTH SCIENCES CENTER AURORA CO
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| Thyroid Hormone Responsive Protein Spot14 (S14) is necessary for high rate de novo fatty acid synthesis. Elevated S14 is correlated with reduced disease free survival of women afflicted with breast cancer. The molecular mechanism of S14 remains illusive. Two models exist for S14 function: one suggesting transcriptional events and the other in metabolic processes. Our previous findings showed that S14 does not alter lipogenic gene expression in the cell lines ... |
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| Characterization of Human Serum Butyrylcholinesterase in Rhesus Monkeys: Behavioral and Physiological Effects |
Jan 2012 |
1 pages |
| Authors:
Todd M Myers; Wei Sun; Ramachandra S Naik; Matthew G Clark; Bhupendra P Doctor; Ashima Saxena; ARMY MEDICAL RESEARCH INST OF CHEMICAL DEFENSE ABERDEEN PROVING GROUND MD
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| The effects of a large dose of human serum butyrylcholinesterase (HuBChe) were evaluated in rhesus monkeys using a serial-probe recognition (SPR) task designed to assess attention and short-term memory. |
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| Lower Prediagnostic Serum 25-Hydroxyvitamin D Concentration Is Associated With Higher Risk of Insulin-requiring Diabetes: A Nested Case-Control Study |
Jan 2012 |
5 pages |
| Authors:
E D Gorham; C F Garland; A A Burgi; S B Mohr; K Zeng; H Hofflich; J J Kim; C Ricordi; NAVAL HEALTH RESEARCH CENTER SAN DIEGO CA
|
| Aims/hypothesis Low serum 25-hydroxyvitamin D [25 (OH)D] concentration may increase risk of insulinrequiring diabetes. Methods A nested case control study was performed using serum collected during 2002 2008 from military service members. One thousand subjects subsequently developed insulin-requiring diabetes. A healthy control was individually matched to each case on blood-draw date ( 2 days), age ( 3 months), length of service ( 30 days) and sex. The median elapsed time ... |
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| Aerobic Exercise, Estrogens, and Breast Cancer Risk |
Nov 2011 |
27 pages |
| Authors:
Alma Smith; MINNESOTA UNIV MINNEAPOLIS
|
| With approximately 180,000 new cases reported in 2008, breast cancer continues to be the most frequently diagnosed non-skin cancer and second leading cause of cancer death among American women.1 A large body of epidemiological evidence suggests increasing levels of physical activity are associated with significant reductions in breast cancer risk.2, 3 The goal of this training grant was to investigate the effects of a 16-week, aerobic exercise intervention on endogenous ... |
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| Serum Penicillin G Levels Are Lower Than Expected in Adults within Two Weeks of Administration of 1.2 Million Units |
Oct 2011 |
7 pages |
| Authors:
Michael P Broderick; Christian J Hansen; Kevin L Russell; Edward L Kaplan; Jeffrey L Blumer; Dennis J Faix; NAVAL HEALTH RESEARCH CENTER SAN DIEGO CA
|
| When introduced in the 1950s, benzathine penicillin G (BPG) was shown to be effective in eradicating group A beta-hemolytic streptococcus (GAS) for at least 3 weeks after administration. Several studies since the 1990s suggest that at 3-4 weeks serum penicillin G levels are less than adequate (below MIC(exp 90) of 0.016 mg/ml). We studied these levels for 4 weeks after the recommended dose of BPG in military recruits, for whom ... |
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| Improving the Efficiency and Efficacy of Glibenclamide in Limiting Progressive Hemorrhagic Necrosis Following Traumatic Spinal Cord Injury |
Oct 2011 |
6 pages |
| Authors:
J M Simard; MARYLAND UNIV BALTIMORE
|
| Preclinical work has demonstrated that glibenclamide administration improves outcomes in rat models of spinal cord injury, with the principal mechanism of action being amelioration of post-traumatic hemorrhagic necrosis (PHN). We hypothesize that some but not all patients with spinal cord injury, principally those with incomplete lesions, will respond to glibenclamide therapy. Our goal is identify early markers of injury that can be used to predict which patients may benefit from ... |
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| Impact Of Obesity On Tamoxifen Chemoprevention In A Model Of Ductal Carcinoma In Situ |
Oct 2011 |
19 pages |
| Authors:
Sarah D Smith; TEXAS UNIV AT AUSTIN
|
| Obesity increases risk for breast cancer in postmenopausal women and increases mortality in pre- and postmenopausal women, in fact, 30-50% of breast cancer deaths in post-menopausal women may be attributed to excess body weight (1). The HER-2/neu proto-oncogene is amplified in 25-30% of human primary breast cancers, and increased levels of HER-2/neu expression in tumors can have a negative impact on prognosis of the cancer (2). Approximately two-thirds of breast ... |
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| Development of a Native Fractionation Antigen Microarray for Autoantibody Profiling in Breast Cancer |
Oct 2011 |
12 pages |
| Authors:
Brian C Liu; BRIGHAM AND WOMENS HOSPITAL BOSTON MA
|
| The humoral response of a cancer patient may allow earlier detection of cancer than current methods allow. If so, the serum autoantibody repertoire from cancer patients might be exploited for autoantibody profiling, and aid in the serological diagnosis of cancer. In this final report, we report on the development of a whole proteome native antigen microarray for human breast cancer. Using this platform and sera from stage 1 and 2 ... |
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| Use Of Colistin Serum Concentrations After Intravenous Administration Of Colistimethate Sodium To Determine Pharmacokinetic And Pharmacodynamic Relationships |
Oct 2011 |
8 pages |
| Authors:
David Byers; HENRY M JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE ROCKVILLE MD
|
| Purpose: To define the pharmacokinetics of colistin after colistimethate sodium infusion and use clinical and microbiological data to explore pharmacodynamic relationships between colistin plasma levels, clinical and microbiological outcomes and drug-related toxicities. Research Design: Multi-center, prospective, open-label, un-controlled observational study. Methodology/Technical Approach: Five plasma samples from 60 patients 18 years of age receiving colistimethate sodium will be collected, frozen and shipped to Ordway Research Institute where they will be analyzed ... |
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| Proteomics of Peripheral Leukocytes in Patients with Elevated Serum Levels of PSA |
Sep 2011 |
12 pages |
| Authors:
Martin Steffen; BOSTON UNIV MA
|
| During this second year of research, we have modified patient recruitment protocols for a greater sample acquisition rate, and initiated studies in mouse models of prostate cancer. This will allow us to reduce the influence of genetic heterogeneity observed in human populations, and increase our confidence that observed differences in protein levels are the result of a malignant process. From collected patient samples, we now are able to isolate CD4+ ... |
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| Development of Antibodies Against Novel Cell Surface Proteins In Hormone Refractory Prostate Cancer. Addendum |
Jul 2011 |
21 pages |
| Authors:
Zev A Wainberg; CALIFORNIA UNIV LOS ANGELES
|
| N-cadherin is a cell surface marker that is overexpressed in hormone refractory prostate cancer and targeting this protein either diagnostically or therapeutically may have clinical utility. We developed monoclonal antibodies against several ectodomains of N-cadherin that reduced proliferation, adhesion and invasion of prostate cancer cells in vitro. In vivo, these antibodies slowed the growth of multiple established CRPC xenografts, blocked local invasion and metastasis, and at higher doses led to ... |
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| Early Detection of Ovarian Cancer by Contrast-Enhanced Ultrasound-Targeted Imaging |
Jul 2011 |
16 pages |
| Authors:
Animesh Barua; RUSH UNIV MEDICAL CENTER CHICAGO IL
|
| Because of the lack of an effective early detection method, OVCA in most cases are detected at late stages when the rate of 5-year survival is 10%. Although transvaginal ultrasound (TVUS) is the currently favored method, it cannot detect OVCA at early stage due to its limited resolution. Tumor related malignant nuclear transformation is an earlier event in tumor development which leads to the development of anti-Nuclear Matrix Proteins (NMP) ... |
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| Glyco-Immune Diagnostic Signatures and Therapeutic Targets of Mesothelioma |
Jul 2011 |
7 pages |
| Authors:
Margaret Huflejt; NEW YORK UNIV NY SCHOOL OF MEDICINE
|
| This focus of this grant is to investigate immunoprofiles for serum antibodies to aberrant glycans in human and animal models of mesothelioma. This is accomplished using a one of a kind printed glycan array which is at NYU School of Medicine (NYUSoM). It is hoped that these experiments will allow us to diagnose and prognosticate mesothelioma more accurately in the future. We have been severely limited by our ability to ... |
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| Immunopathogenesis In Autism: Regulatory T Cells and Autoimmunity In Neurodevelopment |
Jul 2011 |
14 pages |
| Authors:
Jamie C DeWitt; Qing Hu; EAST CAROLINA UNIV GREENVILLE NC
|
| An immunopathology reported in some autistic patients is development of autoantibodies against brain-specific proteins, which suggests impacts to regulatory T cells (Tregs). Perfluorooctanoic acid (PFOA) and perfluorooctane sultanate (PFOS) are widespread environmental pollutants and induce developmental and immuno-toxicity. Our hypothesis is that developmental exposure to PFOA or PFOS will affect number and/or function of Tregs and increase autoimmune risk in offspring. In immunocompetent male and female offspring exposed to PFOA ... |
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| PROSPECT: Profiling of Resistance Patterns Oncogenic Signaling Pathways in Evaluation of Cancers of the Thorax and Therapeutic Target Identification |
Jun 2011 |
151 pages |
| Authors:
Waun K Hong; M D ANDERSON CANCER CENTER HOUSTON TX
|
| We will develop a high throughput therapeutic-target focused (TTF) profiling platform and will combine this with tumor genome wide mRNA profiling and with serum or plasma profiling of phosphopeptides and DNA. We will use these molecular profiles to help define how various molecular factors alone and in combination relate to resistance to therapy, to prognosis, and to metastatic patterns at relapse. Using tumor and blood samples from non-small cell lung ... |
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| High Serum 25-hydroxyvitamin D is Associated with Low Incidence of Stress Fractures |
Jun 2011 |
28 pages |
| Authors:
Alina A Burgi; Edward D Gorham; Cedric F Garland; Sharif B Mohr; Frank C Garland; Kenneth Zeng; Kerry Thompson; Joan M Lappe; NAVAL HEALTH RESEARCH CENTER SAN DIEGO CA
|
| Low serum 25-hydroxyvitamin D [25(OH)D] levels cause rickets and osteomalacia, but it is unknown whether the condition increases risk of stress fractures in young adult. This study was conducted to determine if young women with low serum 25(OH)D have an increased risk of stress fracture compared to those at higher levels. Methods. The Department of Defense has collected and frozen serum from over nine million service members. Pre-fracture serum specimens ... |
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| Markers of Ovarian Cancer Using a Glycoprotein/Antibody Array |
MAY 2011 |
6 pages |
| Authors:
DAVID M. LUBMAN; MICHIGAN UNIV ANN ARBOR
|
| 14. ABSTRACT Profiling of the glycan structures that differ between the serum of serous ovarian cancer and benign conditions have been performed using lectin arrays for biomarker studies. These arrays have used 16 different lectins which respond to specific glycan structural moieties of glycoproteins in patient serum. It has been found that there are distinct changes in the level of fucosylation between cancer and benign using LCA, AAL and UEA ... |
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| Vaccine Immunotherapy for Prostate Cancer |
May 2011 |
10 pages |
| Authors:
David M Lubaroff; IOWA UNIV IOWA CITY
|
| The purpose of the research supported by this award is to conduct a Phase II clinical trial (study) of an adenovirus/PSA (Ad/PSA) vaccine for the treatment of prostate cancer. Two protocols have been used in the trial: #1 - Phase II study of Adenovirus/PSA vaccine in men with recurrent prostate cancer after local therapy; and #2 - Phase II study of Adenovirus/PSA vaccine in men with hormone refractory prostate cancer. ... |
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| Vitamin D, Vitamin D Receptor Polymorphisms and Breast Cancer Aggressiveness in African American and European American Women |
May 2011 |
39 pages |
| Authors:
Song Yao; ROSWELL PARK CANCER INST BUFFALO NY
|
| Vitamin D may be associated with breast cancer (BC) of poor prognosis, particularly the triple-negative (TN) subtype, which may explain the strikingly high incidence of (TNBC) among African American (AA) women, because AAs have significantly lower vitamin D levels than European Americans (EAs). Pre-treatment 25OHD levels were available from 579 EA BC cases and 574 EA controls, and compared by tumor characteristics with control for covariates. In 547 AA and ... |
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| Prostate Cancer Detection by Molecular Urinalysis |
APR 2011 |
64 pages |
| Authors:
Christian Pavlovich; Brian Matlaga; JOHNS HOPKINS UNIV BALTIMORE MD
|
| Prostate cancer is the most commonly diagnosed cancer and the second leading cause of cancer-related death in the United States. Serum tests for prostate cancer consist essentially of PSA and related isoforms, and when combined with digital rectal examination (DRE) are the mainstays of prostate cancer detection and local staging over the last decade. Recently however, it has become clear that urinary tests for prostate cancer may have a role ... |
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| Stress and Traumatic Brain Injury: A Behavioral, Proteomics, and Histological Study |
07 MAR 2011 |
15 pages |
| Authors:
Sook-Kyung C. Kwon; Erzsebet Koveski; Andrea B. Gyorgy; Daniel Wingo; Alaa Kamnaksh; John Walker; Joseph B. Long; Denes V. Agoston; UNIFORMED SERVICES UNIV OF THE HEALTH SCIENCES BETHESDA MD
|
| Psychological stress and traumatic brain injury (TBI) can both result in lasting neurobehavioral abnormalities. Post-traumatic stress disorder and blast induced TBI (bTBI) have become the most significant health issues in current military conflicts. Importantly, military bTBI virtually never occurs without stress. In this experiment, we assessed anxiety and spatial memory of rats at different time points after repeated exposure to stress alone or in combination with a single mild blast. ... |
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| Proteomic Analysis of Prostate Cancer Field Effect |
Feb 2011 |
28 pages |
| Authors:
Michael J Wilson; MINNESOTA UNIV MINNEAPOLIS
|
| We have undertaken a novel proteomic approach to identify proteins altered in both cancer and benign cells near the cancers. This is to take advantage of the field effect of the cancer, the malignancy associated changes in normal cells, to discover cancer altered protein that could be more abundant in serum or urine since they would come from both benign and cancer cells. We have started statistical evaluation of proteins ... |
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| Serum and Exudate Calcitonin Precursors as Predictors of Wound Infection and Dehiscence in Wartime Penetrating Injuries. Addendum |
Feb 2011 |
6 pages |
| Authors:
Benjamin K Potter; GENEVA FOUNDATION LAKEWOOD WA
|
| To date, we have enrolled 148 patients into the study that have either been wounded in Iraq or Afghanistan and 5 control tissue patients who hae had their patella tendon repaired and donated pieces of the Autologous tendon. |
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| Epigenetic Patterns of PTSD: DNA Methylation In Serum of OIF/OEF Servicemembers |
Jan 2011 |
38 pages |
| Authors:
Jennifer Rusiecki; HENRY M JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE ROCKVILLE MD
|
| The molecular mechanisms involved in PTSD are not well characterized; epigenetic factors could offer new insights. Gene expression studies show differences in cytokine expression signatures between PTSD patients and controls. DNA methylation is intrinsically linked to gene expression. We investigated DNA methylation patterns in repetitive DNA elements and in cytokine promoter regions in soldiers prior to OIF/OEF deployment; serum-derived DNA was used. PTSD cases with existing serum samples housed at ... |
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| Antigen-Specific lgA B Memory Cell Responses to Shigella Antigens Elicited in Volunteers Immunized with Live Attenuated Shigella flexneri 2a Oral Vaccine Candidates |
Jan 2011 |
9 pages |
| Authors:
J K Simon; M Maciel Jr; E D Weld; R Wahid; M F Pasetti; W L Picking; K L Kotloff; M M Levine; M B Sztein; NAVAL MEDICAL RESEARCH CENTER SILVER SPRING MD
|
| We studied the induction of antigen-specific lgA memory B cells (BM) in volunteers who received live attenuated Shigella flexneri 2a vaccines. Subjects ingested a single oral dose of 107 , 108 or 109 CFU of S. flexneri 2a with deletions in guaBA (CVD 1204) or in guaBA, set and sen (CVD 1208). Antigen-specific serum and stool antibody responses to LPS and lpa B were measured on days 0, 7, 14, ... |
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| Isolation of a Novel Orientia Species ( O. chuto sp. nov.) from a Patient Infected in Dubai |
Dec 2010 |
6 pages |
| Authors:
Leonard Izzard; Andrew Fuller; Stuart D Blackwell; Daniel H Paris; Allen L Richards; Nuntipa Aukkanit; Chelsea Nguyen; Ju Jiang; Stan Fenwick; Nicholas P Day; NAVAL MEDICAL RESEARCH CENTER SILVER SPRING MD RICKETTSIAL DISEASES DEPT
|
| In July 2006, an Australian tourist returning from Dubai, in the United Arab Emirates (UAE), developed acute scrub typhus. Her signs and symptoms included fever, myalgia, headache, rash, and eschar. Orientia tsutsugamushi serology demonstrated a 4-fold rise in antibody titers in paired serum collections (1:512 to 1:8,192), with the sera reacting strongest against the Gilliam strain antigen. An Orientia species was isolated by the in vitro culture of the patient's ... |
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| Ovarian Cancer Immunotherapy Using Redirected Endogenous Anti-Gal Antibody |
OCT 2010 |
10 pages |
| Authors:
Paul Sondel; Alexander Rakhmilevich; WISCONSIN UNIV-MADISON
|
| We proposed that decorating ovarian tumor cells with alphaGal (using RGD*-alphaGal) will lead to their destruction by patients' naturally occurring antibody against alphaGal. This past year we developed an in vitro assay to measure antibody-specific complement-dependent cytotoxicity (CDC) of tumors expressing alphaGal. We showed in mice that human serum containing anti- alphaGal antibody induced specific regression of alphaGal -expressing B16 melanoma far more than the effects against alphaGal nonexpressing B16. ... |
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| Determination of Optimum Vitamin D Nutrition in Young Women |
OCT 2010 |
11 pages |
| Authors:
John C. Gallagher; CREIGHTON UNIV OMAHA NE
|
| The main objective of this proposal is to study the effect of increasing doses of vitamin D3 in a group of young women with hypovitaminosis D (serum 25OHD < 20 ng/ml) and an adequate calcium intake of 1200 -1400mg/day. This is a double blind randomized placebo controlled study .There will be 5 treatment arms, four vitamin D3 dose groups (400, 800, 1600, 2400 IU/day, placebo). Calcium citrate tablets will be ... |
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| Circadian Genes and Risk for Prostate Cancer |
SEP 2010 |
7 pages |
| Authors:
Ann W. Hsing; TRUE RESEARCH FOUNDATION SAN ANTONIO TX
|
| We propose that genetic susceptibility to prostate cancer may be in part due to variations in the core circadian genes that regulate circadian rhythms and that serum sex steroid hormone levels modify the effect of circadian gene polymorphisms on prostate cancer risk. Our study is nested within the Prostate Cancer Prevention Trial (PCPT), a randomized placebo-controlled clinical trial to determine if finasteride (an inhibitor of androgen bioactivation) could prevent prostate ... |
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| Regulation of Breast Cancer Stem Cell Trafficking and Metastasis by Brain Originated Signals |
Sep 2010 |
11 pages |
| Authors:
Shuxian Jiang; BETH ISRAEL DEACONESS MEDICAL CENTER BOSTON MA
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| The hypothesis of this study was that adrenergic signaling contributes to reducing the synthesis of CXCL12 by stromal cells, thereby promoting the release of breast tumor-initiating cells in the circulation and that the sympathetic nervous system controls the retention of breast cancer stem cells to their niche through the regulated expression of CXCL12. To address this hypothesis, we examined the role of CXCR4+ CXCL12 in breast cancer stem cell mobilization ... |
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| Serum and Exudate Calcitonin Precursors as Predictors of Wound Infection and Dehiscence in Wartime Penetrating Injuries |
Aug 2010 |
6 pages |
| Authors:
Benjamin K Potter; GENEVA FOUNDATION LAKEWOOD WA
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| Patient enrollment has rapidly accelerated in the past few months, in part due to re-doubling of recruitment efforts and in part due to increased casualty flow. To date 124 patients have been enrolled into the study that have either been wounded in Iraq or Afghanistan and 5 control tissue patients who have had their patella tendon repaired and donated pieces of the Autologous tendon. Due the increased patient enrollment the ... |
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