| Characteristics and Functionalities of Natural and Bioinspired Nanomaterials |
May 2012 |
204 pages |
| Authors:
Lijin Xia; TENNESSEE UNIV KNOXVILLE
|
 | Green nanoscience is a rapidly emerging field that aims to achieve the maximum performance and benefits from nanotechnology, while minimizing the impact on the environment. In this study, several methods for the green nanomanufacturing of biomedically important nanomaterials, specifically through the use of natural plants, have been extensively investigated. It was found that natural nanomaterials are inherent within plants, and can be further manipulated for potential biomedical applications. In addition, ... |
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| Peer Reviewed Cancer Research Program Fiscal Year 2012 Report to Congress |
21 Feb 2012 |
25 pages |
| Authors:
ARMY MEDICAL RESEARCH AND MATERIEL COMMAND FORT DETRICK MD
|
| The U.S. Army Medical Research and Materiel Command (USAMRMC) is a major subordinate Command of the U.S. Army Medical Command. The USAMRMC manages biomedical research and development programs that are part of the Department of Defense (DoD). Congressional appropriations totaling over $6 billion for fiscal years 1992 to 2012 (FY92-FY12) assigned to the USAMRMC are managed by the office of the Congressionally Directed Medical Research Programs (CDMRP), a subordinate organization ... |
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| The United States Army Medical Department Journal. October-December 2011 |
Dec 2011 |
96 pages |
| Authors:
ARMY MEDICAL DEPT CENTER AND SCHOOL FORT SAM HOUSTON TX
|
| The Army Medical Department Journal [ISSN 1524-0436] is published quarterly for The Surgeon General by the US Army Medical Dept Center & School, Journal Office, AHS CDD Bldg 4011, 2377 Greeley RD STE T, Fort Sam Houston, TX 78234-7584. Articles published in The Army Medical Department Journal are listed and indexed in MEDLINE, the National Library of Medicine s premier bibliographic database of life sciences and biomedical information. As such, ... |
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| Veterinary Research Manpower Development for Defense |
Sep 2011 |
19 pages |
| Authors:
M S Anwer; TUFTS COLL MEDFORD MA
|
| The long-term goal of this training program is to increase veterinary research manpower by providing research training to veterinary students. The proposed training program included joint degree programs (DVM/MPH, DVM/MS-CBS and DVM/MS-LAM) and the summer research program. Five trainees have graduated from TCSVM and are currently serving in US Army Veterinary Corps (1), enrolled in LAM residency program (2), conducting biomedical research (1) and in private practice (1). The 33 ... |
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| HBCU Summer Undergraduate Training Program in Prostate Cancer Research |
Aug 2011 |
43 pages |
| Authors:
Shiv Srivastava; HENRY M JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE ROCKVILLE MD
|
| The goal of this award was to provide prostate cancer (CaP) research summer internships to the students of the University of the District of Columbia (UDC) at the Uniformed Services University of the Health Sciences (USU)-Center for Prostate Disease Research (CPDR). The main objective was to expose students to stimulating research environment that would encourage them to pursue research or medical careers in prostate cancer or relevant biomedical fields. During ... |
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| Pittsburgh-Tuskegee Prostate Training Program (PTPTP) |
APR 2011 |
8 pages |
| Authors:
Alan Wells; PITTSBURGH UNIV PA
|
| Prostate cancer disproportionately afflicts African-American men. As such, we feel that it is critically important to recruit researchers from this population if we are to conquer this disease. Numerous programs have attempted to recruit minorities to biomedical research and prostate cancer in particular. Often this involves a short period of research immersion during a summer semester. However, it has been shown that many of these trainees do not persevere in ... |
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| Research to Develop Biomedical Applications of Free Electron Laser Technology |
31 MAR 2011 |
48 pages |
| Authors:
Rox Anderson; Michael Hamblin; Tayyaba Hasan; Irene Kochevar; Charles Lin; MASSACHUSETTS GENERAL HOSPITAL BOSTON WELLMAN LABS OF PHOTOMEDICINE
|
| The overall goal is to solve substantial military medical problems by creating technologies that are useful to diagnose and care for soldiers, and by elucidating the mechanisms of organ trauma and diseases that particularly affect soldiers. To achieve this broad goal, we have undertaken projects focused on novel treatments of infectious diseases and physical trauma relevant to military personnel, technological improvements for trauma care, and new approaches to triage. Infectious ... |
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| Methods of Evaluating Protective Clothing Relative to Heat and Cold Stress: Thermal Manikin, Biomedical Modeling, and Human Testing |
Jan 2011 |
13 pages |
| Authors:
Catherine O'Brien; Laurie A Blanchard; Bruce S Cadarette; Thomas L Endrusick; Xiaojiang Xu; Larry G Berglund; Michael N Sawka; Reed W Hoyt; ARMY RESEARCH INST OF ENVIRONMENTAL MEDICINE NATICK MA THERMAL AND MOUNTAIN MEDICINE DIVISION
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| Personal protective equipment (PPE) refers to clothing and equipment designed to protect individuals from chemical, biological, radiological, nuclear, and explosive hazards. The materials used to provide this protection may exacerbate thermal strain by limiting heat and water vapor transfer. Any new PPE must therefore be evaluated to ensure that it poses no greater thermal strain than the current standard for the same level of hazard protection. This review describes how ... |
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| Accelerating Biomedical Research in Designing Diagnostic Assays, Drugs, and Vaccines |
Oct 2010 |
11 pages |
| Authors:
Anders Wallqvist; Nela Zavaljevski; Ravi V Satya; Rajkumar Bondugula; Valmik Desai; Xin Hu; Kamal Kumar; Michael S Lee; In-Chul Yeh; Chenggang Yu; ARMY MEDICAL RESEARCH AND MATERIEL COMMAND FORT DETRICK MD TELEMEDICINE AND ADVANCED TECH RESEARCH CENTER
|
| The US Department of Defense Biotechnology High-Performance Computing Software Applications Institute for Force Health Protection develops state-of-the-art high-performance computing applications that accelerate biomedical research in the development of diagnostic assays, drugs, and vaccines. The BHSAI works together with DoD life scientists to develop and integrate HPC software applications into DoD biomedical research programs. |
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| Transition of DoD Technologies in Support of Humanitarian Assistance and Disaster Relief Operations |
14 Jan 2010 |
15 pages |
| Authors:
Earl Wyatt; OFFICE OF THE DIRECTOR OF DEFENSE RESEARCH AND ENGINEERING WASHINGTON DC RAPID FIELDING DIRECTORATE
|
| Topics addressed in these briefing charts include: humanitarian assistance, disaster relief, missions, situational awareness, transportation, biomedical concerns, energy, communications, planning and opportunities for improvement and collaboration. |
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| What are the Ethical Problems Raised by the Increase of Cognitive Capabilities in the Defence Structure: The French Legal Structure, the Ethical Position of the French Military Health Service |
Oct 2009 |
16 pages |
| Authors:
Marion Trousselard; CENTRE DE RECHERCHES DU SERVICE DE SANTE DES ARMEES LA TRONCHE (FRANCE) DEPARTMENT DES FACTEURS HUMAINS
|
| All contemporary discussions concerning the ethics of human experimentation are grounded in the Nuremberg Code [1]. It defined the general agenda and language of all subsequent ethical and legal questions concerning the proper conduct of human experimentation, and listed what for many are the basic principles underlying the ethical conduct of human research. Consequently, the Nuremberg Code, which was included in the 1947 judgment of the Nuremberg Medical Trial, greatly ... |
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| Prairie View A&M/Baylor College of Medicine SMART Summer Undergraduate Prostate Cancer Research Project |
Apr-2009 |
8 pages |
| Authors:
Nancy L Weigel; B G Slaughter; BAYLOR COLL OF MEDICINE HOUSTON TX
|
| The goal of this project is to encourage undergraduates to enter careers in prostate cancer research. This project involves BCM faculty presentations at Prairie View A & M University and a 9 week summer prostate cancer research experience at BCM for up to 5 undergraduates/year from PVAMU (3 in 2006; 4 in 2007 and 2008). Participants attended a weekly research discussion group focused on prostate cancer. Students make PowerPoint presentations ... |
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| Chemical/Radiation Hormesis Database, Evaluation of Hormetic Mechanisms and their Biomedical and Risk Assessment Implications |
MAR 2008 |
8 pages |
| Authors:
Edward J. Calabrese; MASSACHUSETTS UNIV AMHERST SCHOOL OF PUBLIC HEALTH
|
| This project assessed the biomedical and toxicological literature for evidence of hormesis, its frequency in the literature and its underlying mechanistic foundation. This work was supported by the continued development of the hormesis database and the conduct of a high level international conference on hormesis held annually. Particular focus was given to the area of neuroscience and hormesis in the literature assessment. Fourteen manuscripts concerning hormesis and neuroscience have been ... |
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| Subcellular Responses to Narrowband and Wideband Radiofrequency Radiation |
15 FEB 2008 |
52 pages |
| Authors:
Karl H. Schoenbach; Charles C. Tseng; OLD DOMINION UNIV RESEARCH FOUNDATION NORFOLK VA
|
| The interest in subcellular effects of radiofrequency radiation has led to the establishment of a Multidisciplinary University Research Initiative (MURI) with scientists from six academic institutions (Old Dominion University, Eastern Virginia Medical School, Massachusetts Institute of Technology, Washington University, University of Wisconsin and University of Texas Health Science Center) participating. The ODU-led MURI worked closely with its sister MURI, led by Purdue Calumet University. The research work in the ODU ... |
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| Text Mining the Biomedical Literature |
05 NOV 2007 |
381 pages |
| Authors:
Ronald N. Kostoff; OFFICE OF NAVAL RESEARCH ARLINGTON VA
|
| Text mining of the biomedical literature provides patterns of relationships among concepts, people, and institutions, offering enhanced medical/technical intelligence unobtainable by other means. This report describes myriad text mining capabilities. Section 1 covers biomedical knowledge management, the role of text mining in knowledge management, and describes the cultural changes and global agreements required to allow the full power and capabilities of text mining to be utilized. The next two sections ... |
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| Literature-Related Discovery: A Review |
05 NOV 2007 |
59 pages |
| Authors:
Ronald N. Kostoff; Joel A. Block; Jeffrey L. Solka; Michael B. Briggs; Robert L. Rushenberg; Jesse A. Stump; Dustin Johnson; Terence J. Lyons; Jeffrey R. Wyatt; OFFICE OF NAVAL RESEARCH ARLINGTON VA
|
| Discovery in science is the generation of novel, interesting, plausible, and intelligible knowledge about the objects of study. Literature-related discovery (LRD) is the linking of two or more literature concepts that have heretofore not been linked to produce novel interesting, plausible, and intelligible knowledge (i.e., potential discovery). Two major variants of LRD are open discovery systems (ODS), where one starts with a problem and generates a potential solution (or vice ... |
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| Static and Dynamic Magnetic Response in Ferrofluids |
30 OCT 2007 |
12 pages |
| Authors:
Hariharan Srikanth; UNIVERSITY OF SOUTH FLORIDA TAMPA
|
| Ferrofluids are technologically important for a variety of applications ranging from biomedicine, hydraulics, to power generation. They are also model systems for the investigation of physics of relaxation phenomena in magnetic nanoparticles. We have done systematic DC and AC magnetization studies of ferrofluids composed of Fe3O4 and CoFe2O4 nanoparticles (mean size 14 nm) suspended in hexane and dodecane, respectively. The blocking temperature was just above (hexane) and much below (dodecane) ... |
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| Nitric Oxide Generating Polymeric Coatings for Subcutaneous Glucose Sensors |
OCT 2007 |
11 pages |
| Authors:
Mark E. Meyerhoff; MICHIGAN UNIV ANN ARBOR
|
| Heretofore efforts to develop implantable sensors for real-time clinical monitoring of glucose subcutaneously (SQ) in diabetic patients have been hindered by the unreliable analytical results owing largely to biocompatibility problems induced by sensor implantation (e.g. inflammatory/foreign body response). The goal of this research program is to explore and optimize the chemistries required to fabricate implantable amperometric glucose sensors with outer polymeric coatings that slowly generate low levels of nitric oxide ... |
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| Molecular Imaging With Quantum Dots Probing EMT and Prostate Cancer Metastasis in Live Animals |
OCT 2007 |
57 pages |
| Authors:
Leland W. K. Chung; EMORY UNIV ATLANTA GA
|
| Despite the development of various animal and tissue culture models for the study of human prostate cancer growth and metastasis, there is no non-invasive model that provides real-time information on the behavior of prostate cancer cells in the prostate or at distant sites. The goal of this application is to devise a highly sensitive and specific nanotechnology- based molecular imaging technique to detect prostate cancer growth locally and at distant ... |
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| International Assessment of Research and Development in Brain-Computer Interfaces. WTEC Panel Report |
OCT 2007 |
235 pages |
| Authors:
Theodore W. Berger; John K. Chapin; Greg A. Gerhardt; Dennis J. McFarland; Jose C. Principe; Walid V. Soussou; Dawn M. Taylor; Patrick A. Tresco; WORLD TECHNOLOGY EVALUATION CENTER INC BALTIMORE MD
|
| Brain-computer interface (BCI) research deals with establishing communication pathways between the brain and external devices. BCI systems can be broadly classified depending on the placement of the electrodes used to detect and measure neurons firing in the brain: in invasive systems, electrodes are inserted directly into the cortex; in noninvasive systems, they are placed on the scalp and use electroencephalography or electrocorticography to detect neuron activity. This WTEC study was ... |
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| Advanced Processing for Biomedical Informatics (APBI) |
Oct 2007 |
6 pages |
| Authors:
Craig D Shriver; HENRY M JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE ROCKVILLE MD
|
| A research consortium including Windber Research Institute (WRI), the US Army Space and Missile Defense Command (USASMDC), the Joyce Murtha Breast Care Center (JMBCC), and the Clinical Breast Care Project (CBCP) Walter Reed Army Medical Center (WRAMC) has been formed to evaluate the use of minimally-invasive methods for screening including mammography, ultrasound, proteomics and genomics, in the serum and breast for early detection of markers for risk of disease or ... |
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| Chapter 9 - Neurotoxicological Interactions with Physical and Psychological Stressors |
SEP 2007 |
27 pages |
| Authors:
Karl Friedl; Stephen Grate; Susan Proctor; ARMY RESEARCH INST OF ENVIRONMENTAL MEDICINE NATICK MA THERMAL AND MOUNTAIN MEDICINE DIVISION
|
| Over the past deade, the U.S. DoD invested >150M to investigate undiagnosed Gulf War Illness (GWI) and more than twice that amount in clinical management and related efforts with regard to the same issues. The research produced important new understanding of post-deployment health issues and potentially hazardous occupational, materiel, and environmental exposures. Gulf War Illnesses issues also created a new awareness of important neuropsychological and neurotoxicological interactions which were not ... |
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| Fatigue in Military Operational Environments: An Annotated Bibliography |
JUL 2007 |
76 pages |
| Authors:
Nita L. Miller; Lawrence G. Shattuck; Panagiotis Matsangas; NAVAL POSTGRADUATE SCHOOL MONTEREY CA
|
| Research involving sleep and fatigue in military operations has been conducted for many years. Indeed, following nearly every major military engagement or conflict, reports are published which detail the effects of sleep deprivation on human performance. Unfortunately, many of these reports never make it to the scientific literature, and are published instead as technical reports. Following an extensive search of all available data sources including open scientific journals and electronic ... |
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| Summer Undergraduate Fellowships in Breast Cancer Research |
01 MAY 2007 |
8 pages |
| Authors:
Barbara A. Christy; TEXAS UNIV HEALTH SCIENCE CENTER AT SAN ANTONIO
|
| The aim of this grant was to support a summer training program for undergraduate students interested in biomedical research, especially cancer-related research. The students selected for the program participated in cancer-related basic research for a 10-week summer period in the Department of Molecular Medicine, University of Texas Health Science Center at San Antonio. Each student was assigned a faculty mentor and placed in a laboratory, depending on their expressed interests. ... |
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| The Role of Telomeric Repeat Binding Factor 1 (TRF1) in Telomere Maintenance and as a Potential Prognostic Indicator in Human Breast Cancer |
APR 2007 |
19 pages |
| Authors:
Kimberly S. Bulter; Jeffrey K. Griffith; ALBUQUERQUE UNIV NM
|
| The aims of this study are to (i) determine the relationships between the telomere binding protein Telomere Repeat Binding Factor I (TRFI) and other telomere binding prnteins (ii) establish the potential of TRFI as a surrogate marker for telomere content (TC) and as a potential clinical marker and (iii) characterize the relationship between of the telomere binding protein TRFI and TC. Through examining the role of TRFI in telomere length ... |
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| Transurethral Ultrasound Diffraction Tomography |
MAR 2007 |
48 pages |
| Authors:
Matthias C. Schabel; UTAH UNIV SALT LAKE CITY
|
| The potential for cost-effective tomographic imaging using ultrasound continues to be confronted with difficulties arising from the computational complexity of fully three-dimensional object reconstruction in the diffraction regime. Development of fast and accurate forward and inverse models for ultrasound propagation in the biomedical frequency range of 1-10 MHz is essential for diffraction tomography to be a practical imaging modality. We have implemented a flexible, object-oriented simulation system in MATLAB for ... |
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| U.S. National Science Foundation: An Overview |
24 JAN 2007 |
|
| Authors:
Christine M. Matthews; LIBRARY OF CONGRESS WASHINGTON DC CONGRESSIONAL RESEARCH SERVICE
|
 | The National Science Foundation (NSF) was created by the National Science Foundation Act of 1950, as amended (P.L. 81-507). The NSF has the broad mission of supporting science and engineering in general and funding basic research across many disciplines. The agency provides support for investigator-initiated, merit-reviewed, competitively selected awards, state-of-the-art tools, and instrumentation and facilities. The majority of the research supported by the NSF is conducted at U.S. colleges and ... |
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| Efforts and Programs of the Department of Defense Relating to the Prevention, Mitigation, and Treatment of Blast Injuries |
Jan-2007 |
55 pages |
| Authors:
DEPARTMENT OF DEFENSE WASHINGTON DC
|
| Section 256 of the National Defense Authorization Act for Fiscal Year 2006, Public Law 109-163, provides that the Secretary of Defense shall submit a report on the efforts and programs of the Department of Defense (DoD) relating to the prevention, mitigation, and treatment of blast injuries. The report is to include the following elements of information: 1. A description of the activities undertaken under this section during the 2 years ... |
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| Nitric Oxide Generating Polymeric Coatings for Subcutaneous Glucose Sensors |
OCT 2006 |
8 pages |
| Authors:
Mark E. Meyerhoff; MICHIGAN UNIV ANN ARBOR
|
| Heretofore, efforts to develop implantable chemical sensors for real-time clinical monitoring of glucose subcutaneously (SQ) in diabetic patients have been stymied by the unreliable analytical results owing largely to biocompatibility problems induced by sensor implantation (e.g., inflammatory/foreign body response). The goal of this research program is to explore and optimize the chemistries required to fabricate implantable amperometric glucose sensors with outer polymeric coatings that slowly generate low levels of nitric ... |
|
| Translational Health: The Next Generation of Medicine |
SEP 2006 |
35 pages |
| Authors:
Richard J. Mural; WINDBER RESEARCH INST PA
|
| The "Translational Health - the Next Generation of Medicine" conference brought together scientists and medical professionals from across the country and Europe to present and discuss their research and clinical findings in all phases of biomolecular research including DNA sequencing, genotyping, expression analysis, protein separation and identification, and biomedical informatics analysis. This conference resulted in a greater understanding of human diseases and how through combining systems biology and high-throughput molecular ... |
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| High Speed Vessel Medical Limited Objective Experiment, Noise Assessment and Noise Reducing Stethoscope Field Test |
26 AUG 2006 |
20 pages |
| Authors:
Joseph S. Russotti; Christopher Duplessis; NAVAL SUBMARINE MEDICAL RESEARCH LAB GROTON CT
|
| Throughout NSMRL's pursuit in making optimal use of auditory information in sonar displays, interference from airborne sound in the listening environment has been a major issue. NSMRL's success in using active noise cancellation to prevent masking by airborne sound has lead to the realization that shipboard spaces may be habitable by hearing-risk standards, but not operationally suitable for critical mission tasks. Digital sound processing has opened up the auditory detection, ... |
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| Joint Entropy Minimization for Learning in Nonparametric Framework |
09 JUN 2006 |
|
| Authors:
Parvez Ahammad; CALIFORNIA UNIV BERKELEY DEPT OF ELECTRICAL ENGINEERING AND COMPUTER SCIENCE
|
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| Time Delay Systems with Distribution Dependent Dynamics |
10 MAY 2006 |
15 pages |
| Authors:
H. T. Banks; Sava Dediu; Hoan K. Nguyen; NORTH CAROLINA STATE UNIV AT RALEIGH CENTER FOR RESEARCH IN SCIENTIFIC COMPUTATION
|
| General delay dynamical systems in which uncertainty is present in the form of probability measures dependent dynamics are considered. Several motivating examples arising in biology are discussed. A functional analytic framework for investigating well-posedness (existence, uniqueness and continuous dependence of solutions), inverse problems, sensitivity analysis and approximations of the measures for computational purposes is surveyed. |
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| Command History OPNAV 5750-1, Fiscal Year 2004 |
04 MAY 2006 |
41 pages |
| Authors:
Jerry Lamb; Maria Fitzgerald; Heather Huebner; NAVAL SUBMARINE MEDICAL RESEARCH LAB GROTON CT
|
| This is the Command History, OPNAV 5750-1, for the Naval Submarine Medical Research Laboratory, for Fiscal Year 2004. This FY04 report begins October 1, 2003 and ends September 30, 2004. The previous report SR 04-01 was recorded by calendar year beginning January 1, 2003 and ending December 31, 2003, therefore, some duplication may exist. The Naval Submarine Medical Research Laboratory's (NSMRL) mission is to protect the health and enhance the ... |
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| Summer Undergraduate Training Program in Breast Cancer Research |
MAY 2006 |
10 pages |
| Authors:
G. M. Loudon; David Riese; PURDUE UNIV LAFAYETTE IN
|
| Year 04 of the Undergraduate Training Program in Breast Cancer Research has been completed successfully. In addition to the eight students funded by this grant, two additional students were recruited and funded by the Dean of Pharmacy or by individual grants. Eight different mentors were involved. In the four years of the program, 24 of the 42 participants have been women, which are underrepresented in the biomedical research community. Students ... |
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| Patent Reform: Issues in the Biomedical and Software Industries |
07 APR 2006 |
|
| Authors:
Wendy H. Schacht; LIBRARY OF CONGRESS WASHINGTON DC CONGRESSIONAL RESEARCH SERVICE
|
| Congress currently is considering reform of the existing patent system. This interest in patent policy reflects a recognition of the increasing importance of intellectual property to U.S. innovation. Patent ownership is perceived as an incentive to the technological advancement that leads to economic growth. As such, the number of patent applications and grants has grown significantly, as have the type and breadth of inventions that can be patented. Along with ... |
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| The Role of Telomeric Repeat Binding Factor 1 (TRF1) in Telomere Maintenance and as a Potential Prognostic Indicator in Human Breast Cancer |
APR 2006 |
15 pages |
| Authors:
Kimberly S. Bulter; Jeffrey K. Griffith; NEW MEXICO UNIV ALBUQUERQUE
|
| The aims of this study are to (i) determine the relationships between the telomere binding protein Telomere Repeat Binding Factor i (TRF1) and other telomere binding proteins, (ii) establish the potential is TRF1 as a surrogate marker for telomere content (TC) and as a potential clinical marker and (iii) characterize the relationship between is the telomere binding protein TRF1 and TC. Through examining the role is TRF1 in telomere length ... |
|
| BotXminer: Mining Biomedical Literature with a New Web-Based Application |
21 MAR 2006 |
6 pages |
| Authors:
Uma Mudunuri; Robert Stephens; David Bruining; David Liu; Frank J. Lebeda; NATIONAL CANCER INST FREDERICK MD
|
| This paper outlines botXminer, a publicly available application to search XML-formatted MEDLINE data in a complete, object-relational schema implemented in Oracle XML DB. An advantage offered by botXminer is that it can generate quantitative results with certain queries that are not feasible through the Entrez-PubMed interface. After retrieving citations associated with user-supplied search terms, MEDLINE fields (title, abstract, journal, MeSH and chemical) and terms (MeSH qualifiers and descriptors, keywords, author, ... |
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| A Novel Approach to Monitoring Prostate Tumor Oxygenation: Proton MRI of the Reporter Molecule Hexamethyldisiloxane |
MAR 2006 |
21 pages |
| Authors:
Weina Cui; TEXAS UNIV AT DALLAS SOUTHWESTERN MEDICAL CENTER
|
| Growing evidence iron experimental and clinical studies confirms that solid human tumors have foci of hypoxic cells, which have a profound influence on the therapeutic outcome of cancer chemotherapy and radiotherapy. A strong argument therefore exists for assessing the hypoxic traction of tumors prior to patient treatment, and to tailor this treatment accordingly. It bas been shown that there is linear relationship between R1 of hexamethyldisiloxane (HMDSO) and pO2 and ... |
|
| Office of Naval Research-Interns in Biomolecular Sciences Multi-Institutional Research Enhancement Partnership Program: Research Leadership for the 21st Century |
03 JAN 2006 |
4 pages |
| Authors:
Diana Avila; Paulinus Chigbu; Mario Garcia-Rios; James R. Wild; SAINT MARY'S UNIV OF SAN ANTONIO TX
|
| The objective of this program is to enhance the research training of undergraduate students in the biological sciences, particularly underrepresented ethnic minorities and women. The participants are from four minority-serving teaching institutions: Jackson State University (JSU), Jackson, MS; St. Mary's University (StMU), San Antonio, TX); Texas A & M International University (TAMIU), Laredo, TX; and Texas A & M University, College Station, TX (TAMU-CS). During this reporting period, 12 highly ... |
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| Second CIMIT/TATRC Symposium on Plug-and-Play (PNP) Interoperability Medical Devices in the ORF of the Future |
JAN 2006 |
27 pages |
| Authors:
Julian M. Goldman; MASSACHUSETTS GENERAL HOSPITAL BOSTON
|
| Funding was requested for a symposium to continue the process of defining technical and clinical requirements for a Medical Device Plug-and-Play (MD PnP) interoperability standardization framework for medical devices in the Operating Room of the Future and across the continuum of healthcare. The two-day symposium convened a group of 85 medical device producers, clinical users, biomedical engineers, governmental regulators (the FDA), and standards experts to 1) educate new participants in ... |
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| Undergraduate Training Program in Breast Cancer Research |
DEC 2005 |
6 pages |
| Authors:
Suzanne Ostrand-Rosenberg; MARYLAND UNIV BALTIMORE
|
| The goal of this Training Program is to direct talented undergraduates into careers in breast cancer research. The program, called Breast Cancer Undergraduate Research Experience (BCURE), is a joint program between The University of Maryland Baltimore County(UMBC) and the University of Maryland, Baltimore Medical School (UM,B). The centerpiece of BCURE is a full-time, 10-week summer research experience in the laboratory of an established investigator (mentor) working in breast cancer research. ... |
|
| Experimental Results of a MEMS-Based Adaptive Optics System |
DEC 2005 |
5 pages |
| Authors:
Sergio R. Restaino; G. C. Gilbreath; Don M. Payne; Jonathan R. Andrews; NAVAL RESEARCH LAB WASHINGTON DC REMOTE SENSING DIV
|
| Adaptive optics techniques have been demonstrated in both laboratory and field tests, with a great level of scientific satisfaction, especially in astronomical and surveillance communities. Such successes have sparked the interest for these techniques in other fields, like biomedical imaging and industrial applications. However, to decrease complexity and costs, both very important issues for applications other than astronomical and surveillance, new technologies have to be brought to fruition. MEMS are ... |
|
| Molecular Imaging with Quantum Dots Probing EMT and Prostate Cancer Metastasis in Live Animals |
01 OCT 2005 |
25 pages |
| Authors:
Leland W. K. Chung; EMORY UNIV ATLANTA GA
|
| Despite the development of various animal and tissue culture models for the study of human prostate cancer growth and metastasis there is no non-invasive model that provides real-time information on the behavior of prostate cancer cells in the prostate or at distant sites. The goal of this application is to devise a highly sensitive and specific nanotechnology- based molecular imaging technique to detect prostate cancer growth locally and at distant ... |
|
| High-Resolution Speckle-Free Ultrasound Imaging System - A Potential Solution for Detecting Missed Breast Cancer |
OCT 2005 |
55 pages |
| Authors:
Matthew Freedman; GEORGETOWN UNIV WASHINGTON DC MEDICAL CENTER
|
| The Imperium Inc transmission ultrasound system is a highly promising novel method for imaging the breasts. In this pilot project we worked with Imperium to advise and help them modify their existing system for non-destructive testing into one suitable for breast imaging. Technical development of the system took longer than originally anticipated. We have performed a series of physics tests. We have imaged pieces of animal tissue obtained in a ... |
|
| Processing and Development of Nano-Scale HA Coatings for Biomedical Application |
13 JUL 2005 |
7 pages |
| Authors:
Afsaneh Rabiei; Brent Thomas; NORTH CAROLINA STATE UNIV AT RALEIGH DEPT OF MATERIALS SCIENCE AND ENGINEERING
|
| Functionally graded Hydroxyapatite coating with graded Crystallinity across the thickness of the film has been processed and tested as a more effective orthopedic/dental implant coating. The present study aims to increase the service-life of an orthopedic/dental implant by creating materials that form a strong, long lasting, bond with the Ti substrate as well as juxtaposed bone. The health relatedness of the new material is to increase bonding between an implant ... |
|
| Compact Transducers and Arrays |
MAY 2005 |
121 pages |
| Authors:
Robert E. Newnham; Richard J. Meyer Jr.; A. Dogan; J. Tressler; E. Uzgur; D. Markley; A. C. Hladky-Hennion; J. Zhang; PENNSYLVANIA STATE UNIV UNIVERSITY PARK
|
| The main objective of this work is to take traditional high-power, low frequency transducers and miniaturize them to expand the operating range, reduce fabrication costs, and improve performance. This effort began with the development of the "cymbal" and "moonie" miniature flex-tensional transducers. This project improved upon the cymbal design, explored modifications and developed new designs based on other low-frequency technology, such as the hollow sphere and more complex flex-tensionals miniaturized ... |
|
| CIMIT/TATRC Symposium on Developing a Plug-and-Play Open Networking Standard for the Operating Room of the Future |
MAY 2005 |
42 pages |
| Authors:
Julian M. Goldman; MASSACHUSETTS GENERAL HOSPITAL BOSTON
|
| Medicine - and specifically, the operating room environment - has not had the benefit of standardized control and communication systems. As a result, many self-evident improvements - such as seamless data communication, medical device integration, remote device actuation, and distributed closed-loop control systems - have been precluded, and safety and economic benefits have not been realized. Funding was sought for a symposium to begin the process of defining technical and ... |
|
| Summer Undergraduate Training Program in Breast Cancer Research |
MAY 2005 |
30 pages |
| Authors:
G. M. Loudon; David Riese; PURDUE UNIV LAFAYETTE IN
|
| Year 03 of the Undergraduate Training Program in Breast Cancer Research has been completed successfully. In addition to the eight students funded by this grant, two additional students were recruited and funded by the Dean of Pharmacy. Nine different mentors were involved. In the two years of the program thus far, 13 of the 22 participants have been women, who are underrepresented in the biomedical research community. Students carried out ... |
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| Identification of the Types, Properties, and Functional Characteristics of Telomerase Expressing Cells in Breast Cancer |
MAY 2005 |
15 pages |
| Authors:
William C. Hines; Jeffrey K. Griffith; NEW MEXICO UNIV HEALTH SCIENCES CENTER ALBUQUERQUE HEALTH SCIENCES CENTER
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| The aims of this study are to identify the types and properties of telomerase producing cells within breast tumors, and further, to isolate these cells from breast tumors so that their biochemical and functional properties may be characterized. Through examining the role of telomerase in cancer, this project also fosters the education of the candidate through the interaction with several experts in breast cancer pathology, epidemiology, biostatistics, and clinical and ... |
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