| Genomic Approaches for Detection and Treatment of Breast Cancer |
Jul-2009 |
28 pages |
| Authors:
Stephen J Elledge; BRIGHAM AND WOMEN'S HOSPITAL BOSTON MA
|
 | The experiments carried out under this Innovator award allowed us to set up a genetic system to identify genes through loss of function (RNAi) or gain of function (over-expression) functional screens that are capable of influencing cells to acquire tumorlike properties. In this way we have identified many novel tumor suppressors and oncogenes. Many of these are found to be altered in breast cancer and other cancer types. Importantly, we ... |
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| Biological Effects of Electromagnetic Fields |
27 NOV 2006 |
1508 pages |
| Authors:
IOANNINA UNIV (GREECE)
|
| The Final Proceedings for Biological Effects of Electromagnetic Fields held on 16-20 October 2006. |
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| Comparison of Clinical Presentation of Acute Myocarditis Following Smallpox Vaccination to Acute Coronary Syndromes in Patients 40 Years of Age |
15-May-2005 |
5 pages |
| Authors:
Jones; John D Grabenstein; Robert E Eckart; J E Atwood; Eric A Shry; Samuel O IV; BRIGHAM AND WOMEN'S HOSPITAL BOSTON MA
|
| Smallpox vaccine-associated myopericarditis may have a similar presentation to acute coronary syndrome (ACS). The clinical records of 78 young patients (40 years of age) presenting with ACS (n=16) or myocarditis after smallpox vaccination (n=62) were reviewed. Comparisons were made among clinical presentation, cardiac enzymes, echocardiographic findings, and electrocardiographic changes. The presence of cardiac risk factors or focal wall motion abnormalities on echocardiography were associated with a diagnosis of ACS. There ... |
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| New Advanced Technology to Improve Prediction & Prevention of Type 1 Diabetes |
NOV 2004 |
410 pages |
| Authors:
Massimo Trucco; CHILDREN'S HOSPITAL OF PITTSBURGH PA
|
| The research hypothesis on which our project is based is that there is a genetic contribution associated with increased risk for developing diabetic complications, specifically diabetic-nephropathy. That identifying SNP markers linked to this phenotype will enable improved prediction ultimately leading to advances in the prevention of this severe life threatening disease. The final aim of the entire project will be to provide a means to genetically test military personnel and ... |
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| New Advanced Technology to Improve Prediction and Prevention of Type 1 Diabetes |
NOV 2002 |
22 pages |
| Authors:
Massimo Trucco; CHILDREN'S HOSPITAL OF PITTSBURGH PA
|
| Type I diabetes is considered an autoimmune disease characterized by the presence of lymphocytes in the islets of Langerhans. The majority of infiltrating cells are actually T lymphocytes that are considered responsible for the destruction of the insulin producing beta-cells present in the islets. When the number of dead cells reach 85-90% of the originally existing beta- cells, the disease presents, frequently with an abrupt and clinically serious onset. Individuals ... |
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| New Advanced Technology to Improve Prediction and Prevention of Type I Diabetes |
NOV 2001 |
27 pages |
| Authors:
Massimo Trucco; CHILDREN'S HOSPITAL OF PITTSBURGH PA
|
| Type 1 diabetes is considered an autoimmune disease characterized by the presence of lymphocytes in the islets of Langerhans. The majority of infiltrating cells are actually T lymphocytes that are considered responsible for the destruction of the insulin producing beta-cells present in the islets. When the number of dead cells reach 85-90% of the originally existing beta- cells, the disease presents, frequently with an abrupt and clinically serious onset. Individuals ... |
|
| European Cytokine Network. November 2000, Volume 11. Special Issue |
NOV 2000 |
222 pages |
| Authors:
Sherwood M. Reichard; SHOCK SOCIETY AUGUSTA GA
|
| On behalf of the Scientific Program Committee, Officers and Council of the Society, I want to thank the Office of Naval Research for the Support of Symposia and Awards at the Twenty-Third Annual Conference on Shock, June 3-9, 2000, Snowbird, Utah and the Eighth International Cytokine Conference, November 5-9, 2000, RAI, Amsterdam. I am enclosing a copy of SHOCK Volume 13, 2000 supplement which contains the program and abstracts (pages ... |
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| Poliovirus Tumor Vaccine for Breast Cancer Micro-Metastases |
SEP 97 |
10 pages |
| Authors:
Casey D. Morrow; ALABAMA UNIV IN BIRMINGHAM
|
| The underlying reason for failure to cure patients diagnosed with breast cancer is the presence of micrometastases. The stimulation of anti-tumor immune responses represents one of the most effective ways to treat low tumor burdens that are clinically occult. The objective of our proposal is to determine whether a poliovims replicon vaccine strategy induces systemic immunity and eradication of micrometastases. During the second year of our project, we have characterized ... |
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| Psychophysiological Reactions and Immunological Sensitivity to Stress in Healthy Women at Familial Risk for Breast Cancer |
JAN 97 |
19 pages |
| Authors:
Sandra G. Zakowski; Dana H. Bovbjerg; SLOAN-KETTERING INST FOR CANCER RESEARCH NEW YORK
|
| To date 99 women with and without family histories of breast cancer have been recruited. Of those, 84 women have participated in the experimental assessment, 24 women with family histories and 58 women without family histories of breast cancer. Subjects are exposed to two stressful tasks in the laboratory and psychobiological reactivity is measured in response to these tasks. We report several findings: 1) Women with family histories of breast ... |
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| Neural Responses to Injury: Prevention, Protection and Repair; Volume 3: The Neuro-Immunology of Stress, Injury and Infection |
OCT 1996 |
235 pages |
| Authors:
Nicolas G. Bazan; LOUISIANA STATE UNIV NEW ORLEANS
|
| The hypothesis on which this investigation is based is that stressors such as transient temperature changes and restraint signal the central nervous system eliciting the release of catecholamines and adrenal steroids which, in turn, affect the immune system resulting in the reactivation of latent viruses. Employing a mouse model of stress-induced reactivation of herpes simplex virus type 1 (HSV-1), we are determining the time course of viral reactivation relative to ... |
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Reports by Keyword(s)
AUTOIMMUNE REACTIONS
