| Education for Philippine Pacification: How the U.S. Used Education as Part of its Counterinsurgency Strategy in the Philippines from 1898 to 1909 |
14 Dec 2012 |
107 pages |
| Authors:
Louis J Ruscetta; ARMY COMMAND AND GENERAL STAFF COLL FORT LEAVENWORTH KS
|
 | This thesis examines how the United State deliberately used education as part of its counterinsurgency strategy in the Philippines to pacify anti-occupation violence and assimilate the archipelago under American governance. The thesis begins by analyzing American efforts to use education to assimilate and civilize two other racial groups before the Philippine Insurrection: African Americans during the post-Civil War Reconstruction Period and American Indians during the United States' expansion to the ... |
|
| Validation of Computerized Cognitive Assessment in Cross-Cultural Populations |
Oct 2012 |
7 pages |
| Authors:
C M Cullum; Jay H Shore; Myron Weiner; TEXAS UNIV AT DALLAS SOUTHWESTERN MEDICAL CENTER
|
| Traumatic Brain Injury (TBI) has been referred to as the signature injury in Operations Iraqi Freedom and Enduring Freedom, and the Automated Neuropsychological Assessment Metrics (ANAM4), a brief computerized battery of neurocognitive tests, was mandated as a pre-deployment tool in 2008 to help evaluate the effects of TBI. Despite preliminary support for ANAM s correlation with traditional neuropsychological tests, little is known about what constitutes normal performance on ANAM4 among ... |
|
| The Influence of Metabolic Syndrome on Prostate Cancer Progression and Risk of Recurrence in African American and European American Men |
Oct 2012 |
18 pages |
| Authors:
Isaac Powell; Jennifer Beebe-Dimmer; Lance Heilbrun; WAYNE STATE UNIV DETROIT MI
|
| The objective of this study was to establish whether metabolic syndrome plays a role in the progression of prostate cancer and the influence of metabolic syndrome and/or its individual features on the progression of prostate cancer between African American men (AAM) and European American men (EAM). From our results we conclude that both hypertension and metabolic syndrome (defined by possessing 3 of the 4 measured features) are associated with high ... |
|
| Role of Mitochondrial Inheritance on Prostate Cancer Outcome in African American Men |
Oct 2012 |
10 pages |
| Authors:
Martha Mims; BAYLOR COLL OF MEDICINE HOUSTON TX
|
| We are examining the hypothesis that mitochondrial inheritance plays a significant role in aggressiveness of prostate cancer in African Americans. In the first year of the project we have identified 2,000 noncancerous tissues samples from African American men with prostate cancer and we have extracted DNA from 1,500 of them to date. We have validated a robust new DNA sequencing technique developed by our collaborator using single amplicon long-range ... |
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| Biomarkers in the Detection of Prostate Cancer in African Americans |
01 Sep 2012 |
106 pages |
| Authors:
Sandra M Gaston; William E Grizzle; ALABAMA UNIV IN BIRMINGHAM
|
| All IRBs have been approved by the participating sites and the DOD. Dr. Grizzle?s laboratory has completed a pilot analysis by Luminex multiplex immunoassay of serum using two panels of biomarkers, cancer biomarkers (e.g., CA19.9) and inflammatory cytokines (e.g., IL- 17a), to identify potential biomarkers that are differentially expressed. Molecular features that are not differentially expressed and for which there are not apparent racial differences will be excluded in future ... |
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| Adipose Stem Cell-Based Therapeutic Targeting of Residual Androgens in African Americans with Metastatic Prostate Cancer |
01 Sep 2012 |
13 pages |
| Authors:
Asim B Abdel-Mageed; TULANE UNIV NEW ORLEANS LA SCHOOL OF MEDICINE
|
| The disproportionate incidence and mortality of prostate cancer (CaP) among African Americans (AA) in comparison to Caucasian American (CA) are not well understood. It is believed that high circulating androgens reported in AA men may account for such racial disparities. It has been shown that metastatic tumors maintain functional androgen receptor signaling, suggesting that local (intracrine) androgens may contribute to the outgrowth of castration-adapted tumors under androgen deprivation therapy (ADT). ... |
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| Biomarkers in the Detection of Prostate Cancer in African Americans |
Sep 2012 |
106 pages |
| Authors:
William E Grizzle; Sandra M Gaston; ALABAMA UNIV IN BIRMINGHAM
|
| All IRBs have been approved by the participating sites and the DOD. Dr. Grizzles laboratory has completed a pilot analysis by Luminex multiplex immunoassay of serum using two panels of biomarkers, cancer biomarkers (e.g., CA19.9) and inflammatory cytokines (e.g., IL- 17a), to identify potential biomarkers that are differentially expressed. Molecular features that are not differentially expressed and for which there are not apparent racial differences will be excluded in future ... |
|
| Prostate Cancer Genetics in African Americans |
Sep 2012 |
30 pages |
| Authors:
Henry T Lynch; Olugbemi T Ekundayo; Sade Kosoko-Lasaki; Sarah Buxbaum; Carrier Snyder; Ellastine Buckner; Yulia Kinarsky; Prince Andrew; Madisa Johnson; CREIGHTON UNIV OMAHA NE
|
| Our intent has been to identify African American males diagnosed with prostate cancer between the ages of 40 and 75 and registering them along with their at risk relatives into a program of cancer education, cancer screening, and early intervention to reduce disparities in prostate cancer incidence and mortality rates in the African American community in Nebraska and Mississippi. Family history of prostate and other cancers is being recorded with ... |
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| Measuring Social Privilege Attitudes Using a Situational Judgment Test: Validation of the Diversity Engagement Test (DivET) |
28 Jul 2012 |
42 pages |
| Authors:
Neil M Hauenstein; VIRGINIA POLYTECHNIC INST AND STATE UNIV BLACKSBURG DEPT OF PSYCHOLOGY
|
| White privilege is a popular social inequality research topic. However, current attitudinal questionnaires of White privilege are problematic given that the definition of White privilege presumes that the majority of Whites are unaware of their privileged status. The current study proposes that situational judgment tests offer an alternative assessment strategy. The Diversity Engagement Test (DivET) was based on the idea that rationalizations are ubiquitous when defending social privilege, and the ... |
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| Iron Deficiency Anemia, Active Component, U.S. Armed Forces, 2002-2011 |
Jul 2012 |
6 pages |
| Authors:
ARMED FORCES HEALTH SURVEILLANCE CENTER SILVER SPRING MD
|
| Iron deficiency anemia (IDA) is the most common cause of anemia in the United States, and it particularly affects women of child-bearing age and black, non-Hispanic race/ethnicity. During the surveillance period there were 10,157 incident (new) cases of IDA among active component service members the overall incidence rate was 7.1 per 10,000 person-years. The annual incidence rates increased in both males and females during the period. Rates of IDA were ... |
|
| Glycomic Analysis of Prostate Cancer |
Jul 2012 |
17 pages |
| Authors:
Radoslav Goldman; GEORGETOWN UNIV WASHINGTON DC
|
| We are testing the hypothesis that the risk of developing prostate cancer and the aggressiveness of the disease are influenced by protein glycosylation. We postulate that glycobiology contributes to the higher susceptibility of African American men. Newly optimized methods for the glycomic analysis of proteins fractionated into three components are in place. We have assembled the study population and completed the glycomic analysis in two fractions; analysis of the IgA/IgM ... |
|
| microRNAs: Novel Breast Cancer Susceptibility Factors in Caucasian and African American Women |
Jun 2012 |
27 pages |
| Authors:
Hua Zhao; ROSWELL PARK CANCER INST BUFFALO NY
|
| Breast cancer is the most commonly occurring cancer among women. Many risk factors have been identified but a positive family history remains among the most important ones established for breast cancer. Mutations in the currently known high-risk breast cancer genes (such as BRCA1/2, etc) are common in familial breast cancer, but they can explain at best 20-25% of the overall excess familial risk and less than 5% of the total ... |
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| Defining Genomic Changes in Triple-Negative Breast Cancer in Women of African Descent |
Jun 2012 |
12 pages |
| Authors:
Mark Pegram; Lisa L Baumbach; MIAMI UNIV FL
|
| Breast cancer (BC) is the second leading cause of cancer death among African-American (AA) women, with mortality 20% greater than that in Caucasians (Cauc). However, the basis for such disparity remains an enigma. Recent observations from our laboratory suggest the involvement of unidentified genes contributing to AA BC risk. Matched tumor and normal FFPE samples from Cauc and AA patients were obtained from the UM /Sylvester Breast Tissue Bank (UM/S ... |
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| Defining Genomic Changes in Triple-Negative Breast Cancer in Women of African Descent |
Jun 2012 |
12 pages |
| Authors:
Lisa L Baumbach; Mark Begram; MIAMI UNIV FL
|
| Breast cancer (BC) is the second leading cause of cancer death among African-American (AA) women, with mortality 20% greater than that in Caucasians (Cauc). However, the basis for such disparity remains an enigma. Recent observations from our laboratory suggest the involvement of unidentified genes contributing to AA BC risk. Matched tumor and normal FFPE samples from Cauc and AA patients were obtained from the UM /Sylvester Breast Tissue Bank (UM/S ... |
|
| Pittsburgh-Tuskegee Prostate Training Program (PTPTP) |
Apr 2012 |
8 pages |
| Authors:
Alan Wells; PITTSBURGH UNIV PA
|
| Prostate cancer disproportionately afflicts African American men. As such, we feel that it is critically important to recruit researchers from this population if we are to conquer this disease. Numerous programs have attempted to recruit minorities to biomedical research and prostate cancer in particular. Often this involves a short period of research immersion during a summer semester. However, it has been shown that many of these trainees do not persevere ... |
|
| Black General Officers: Why We Lack Them |
22 Mar 2012 |
28 pages |
| Authors:
Lester C Moore; ARMY WAR COLL CARLISLE BARRACKS PA
|
| The American Military is widely viewed as a pioneer in providing equal opportunity for its uniformed members. However, the Military Leadership Diversity Commission (MLDC), which was mandated by the 2009 National Defense Authorization Act (NDAA), calls for greater diversity in the military. The commission declared in March 2011, the United States military is too white and too male at the senior most ranks and needs to change recruiting and promotion ... |
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| Effective Integration Through the Use of Social Influence Tactics: What the Military Can Learn from Racial Integration of Baseball in Ending Don't Ask Don't Tell |
Mar 2012 |
103 pages |
| Authors:
Ernest O Washington; NAVAL POSTGRADUATE SCHOOL MONTEREY CA
|
| Framing tactics are used to structure a situation in an attempt to establish a favorable climate for influence. Framing can be used to influence the military or society to make decisions that are in your best interest (i.e. Jackie Robinson's allowance into major league baseball and the desegregation of the Armed Services) by structuring the issues at hand. The military may be faced with several options; however, introducing social influence ... |
|
| The Impact of Racial Integration on the Combat Effectiveness of Eighth (US) Army during the Korean War |
01 Dec 2011 |
105 pages |
| Authors:
Richard T Cranford; ARMY COMMAND AND GENERAL STAFF COLL FORT LEAVENWORTH KS SCHOOL OF ADVANCED MILITARY STUDIES
|
| This monograph studies the racial integration of Army ground combat units in the U.S. Eighth Army during the Korean War. The purpose of the monograph is to determine how this change in the utilization of African-American soldiers affected the combat effectiveness of a U.S. Army organization engaged in fighting a war. The monograph uses several methods to accomplish this purpose: study of pertinent records and Army doctrine, primary and secondary ... |
|
| Validation of Computerized Cognitive Assessment in Cross-Cultural Populations |
Oct 2011 |
8 pages |
| Authors:
Munro Cullum; TEXAS UNIV SOUTHWESTERN MEDICAL SCHOOL AT DALLAS
|
| Traumatic Brain Injury (TBI) has been referred to as the signature injury in Operations Iraqi Freedom and Enduring Freedom, and the Automated Neuropsychological Assessment Metrics (ANAM4), a brief computerized battery of neurocognitive tests, was mandated as a pre-deployment tool in 2008 to help evaluate the effects of TBI. Despite preliminary support for ANAM's correlation with traditional neuropsychological tests, little is known about what constitutes normal performance on ANAM4 among cultural/ethnic ... |
|
| Race Treatment and Cardiovascular Health: A Study of Men with Prostate Cancer |
Oct 2011 |
11 pages |
| Authors:
Andrea Cassidy-Bushrow; HENRY FORD HEALTH SYSTEM DETROIT MI
|
| As more men live with their prostate cancer, they face increased risk of cardiovascular disease (CVD). This risk is intensified by treatment type, in particular androgen deprivation therapy (ADT). There is a paucity of data exploring the risk of CVD among minority men with prostate cancer overall or by treatment type. The purpose of this study is to examine race-specific CVD risk in men with prostate cancer, overall and by ... |
|
| Ku Klux Rising: Toward an Understanding of American Right Wing Terrorist Campaigns |
Sep 2011 |
292 pages |
| Authors:
Paul D Brister; NAVAL POSTGRADUATE SCHOOL MONTEREY CA DEPT OF NATIONAL SECURITY AFFAIRS
|
| Since 1866, the Ku Klux Klan has been able to muster three distinctive and sustained campaigns of terrorism, commonly referred to as the three waves of Klan violence. The first occurred between 1866 and 1871, the second between 1915 and 1928, and the third from roughly 1954 to the mid-1960s. Subsequent to the third wave, the Klan unsuccessfully attempted another resurgence in the mid-1970s/early 1980s, but was snuffed out before ... |
|
| Multilevel Analysis of Neighborhood Characteristics and Prostate Cancer |
Sep 2011 |
21 pages |
| Authors:
Charnita Zeigler-Johnson; PENNSYLVANIA UNIV PHILADELPHIA
|
| Residing in disadvantaged neighborhoods has been linked to poor disease outcomes. The purpose of this project is to determine if neighborhood characteristics are associated with prostate cancer stage, grade and age at diagnosis in African-American and Caucasian men in the Philadelphia, PA region. In our most recent analysis, we examined prostate cancer patients included in the PA Cancer Registry. We calculated a neighborhood deprivation index and neighborhood deprivation quartiles for ... |
|
| Genome-Wide Association Study in African-Americans With Systemic Lupus Erythematosus |
Sep 2011 |
5 pages |
| Authors:
John Harley; CHILDREN'S HOSPITAL MEDICAL CENTER CINCINNATI OH
|
| Systemic lupus erythematosus is a potentially deadly systemic autoimmune disease that disproportionately afflicts women and African-Americans. This project is designed to discover genes that increase the risk of lupus in African-Americans. Our goal was to expand the genotyping density in African- Americans (2000 cases and 2000 controls) to increase the number and distribution of genetic markers tested. The genotyping on samples collected in Oklahoma and Birmingham is virtually complete. The ... |
|
| Does Lactation Mitigate Triple Negative/Basal Breast Cancer Progression? |
Sep 2011 |
29 pages |
| Authors:
Tanya Russell; COLORADO UNIV AURORA CO SCHOOL OF MEDICINE
|
| The prevalence and mortality rate of triple negative/basal breast cancer is increased young African American women compared to young Caucasian women. We hypothesize that pregnancy and involution without lactation promotes triple negative/basal breast cancer. Aims: 1) Determine if pregnancy and involution, in the absence of lactation, confers tumor promotion. 2) Determine if lactation mitigates promotional effects of pregnancy/involution on tumor progression. Results: Compared to nulliparous controls, tumors in the pregnant ... |
|
| Reducing Prostate Cancer Disparities Through Behavioral and Biologic Epidemiologic Approaches |
Sep 2011 |
19 pages |
| Authors:
Bettina Drake; SAINT LOUIS UNIV MO INST OF TECH
|
| For my cancer epidemiology research to flourish, the next phase of my training should include mentorship and training on the use of behavioral and biologic epidemiological methods concurrently. I seek to utilize this award to accomplish four main objectives: 1) To increase knowledge in and integrate the application of biologic and behavioral epidemiological methods in prostate cancer disparity research; 2) To increase my publication record; 3) To seek and obtain ... |
|
| Vitamin D Levels and Related Genetic Polymorphisms, Sun Exposure, Skin Color, and Risk of Aggressive Prostate Cancer |
Jul 2011 |
8 pages |
| Authors:
Adam B Murphy; NORTHWESTERN UNIV EVANSTON IL
|
| We have been collecting more participants from the participating sites with funding from Dr. Kittles laboratory. Preliminary findings showed that the rates of vitamin D deficiency with prospective specimen collection are 76% of all men. Rates of vitamin D deficiency were approximately 45% of European American men in Chicago and 86-95% of African American men depending on which deficiency cutoff definition used. The most predictive factor for being vitamin D ... |
|
| The Role of Officer Selection and Training on the Successful Formation and Employment of U.S. Colored Troops in the American Civil War, 1863-1865 |
10 JUN 2011 |
105 pages |
| Authors:
Daniel V. Van Every; ARMY COMMAND AND GENERAL STAFF COLL FORT LEAVENWORTH KS
|
| The successful formation and employment of the USCT regiments during the Civil War depended on many factors. The soldiers themselves were highly motivated to succeed. Victory in the war meant permanent freedom for themselves, and their families. But motivation and courage alone do not make a successful military organization. One of the crucial factors that contributed to the success of the USCT was the highly qualified nature of the majority ... |
|
| The Mentorship Course of Action: Increasing African American Interest in the Maneuver Branches. |
10 JUN 2011 |
78 pages |
| Authors:
Jabari M. Miller; ARMY COMMAND AND GENERAL STAFF COLL FORT LEAVENWORTH KS
|
| The maneuver branches have been accessing a relatively low percentage of African American Second Lieutenants in comparison to other branches of the Army. This trend is significant because in the current Army system, a lack of proportional African American participation in the two largest maneuver branches, Infantry and Armor, means that there will likely be a death of African Americans holding senior Army leadership positions in the future. This study ... |
|
| Defining Genomic Changes in Triple Negative Breast Cancer in Women of African Descent |
JUN 2011 |
11 pages |
| Authors:
Mark Pegram; MIAMI UNIV FL
|
| Breast cancer (BC) is the second leading cause of cancer death among African-American (AA) women, with mortality 20% greater than that in Caucasians (Cauc). However, the basis for such disparity remains an enigma. Recent observations from our laboratory suggest the involvement of unidentified genes contributing to AA BC risk. Matched tumor and normal FFPE samples from Cauc and AA patients were obtained from the UM /Sylvester Breast Tissue Bank (UM/S ... |
|
| A Genome-Wide Breast Cancer Scan in African Americans |
Jun 2011 |
22 pages |
| Authors:
Christopher Haiman; UNIVERSITY OF SOUTHERN CALIFORNIA LOS ANGELES
|
| Genome-wide association studies (GWAS) of breast cancer have been completed among populations of European ancestry, and several regions have been identified that appear to contribute susceptibility to this cancer. However, recent data suggest that not all risk alleles for common cancers will be revealed by studies limited to Whites of European ancestry, and that similar efforts in other racial and ethnic populations will be needed to identify the full spectrum ... |
|
| MicroRNAs: Novel Breast Cancer Susceptibility Factors in Caucasian and African American Women |
Jun 2011 |
7 pages |
| Authors:
Hua Zhao; HEALTH RESEARCH INC BUFFALO NY
|
| So far, we have completed the genotyping analysis in 800 Caucasian and 800 African American breast cancer patients, and 800 Caucasian and 800 African American healthy controls. A total of 275 SNPs were analyzed, including 112 SNPs in the microRNA genes, and 163 SNPs in microRNA processing genes. We have identified several SNPs in microRNA processing genes and microRNA genes are associated with breast cancer risk in either Caucasian Americans ... |
|
| Vitamin D, Vitamin D Receptor Polymorphisms and Breast Cancer Aggressiveness in African American and European American Women |
May 2011 |
39 pages |
| Authors:
Song Yao; ROSWELL PARK CANCER INST BUFFALO NY
|
| Vitamin D may be associated with breast cancer (BC) of poor prognosis, particularly the triple-negative (TN) subtype, which may explain the strikingly high incidence of (TNBC) among African American (AA) women, because AAs have significantly lower vitamin D levels than European Americans (EAs). Pre-treatment 25OHD levels were available from 579 EA BC cases and 574 EA controls, and compared by tumor characteristics with control for covariates. In 547 AA and ... |
|
| Pittsburgh-Tuskegee Prostate Training Program (PTPTP) |
APR 2011 |
8 pages |
| Authors:
Alan Wells; PITTSBURGH UNIV PA
|
| Prostate cancer disproportionately afflicts African-American men. As such, we feel that it is critically important to recruit researchers from this population if we are to conquer this disease. Numerous programs have attempted to recruit minorities to biomedical research and prostate cancer in particular. Often this involves a short period of research immersion during a summer semester. However, it has been shown that many of these trainees do not persevere in ... |
|
| Aviation Selection Test Battery Component Predictiveness of Primary Flight Training Outcomes Among Diverse Groups |
MAR 2011 |
97 pages |
| Authors:
Ramon A. Lopez; Tremain L. Denton; NAVAL POSTGRADUATE SCHOOL MONTEREY CA
|
| The Aviation Selection Test Battery (ASTB) has been the qualifying benchmark for the Naval Aviation since World War II. While it is necessary that test scores effectively select the candidates with the greatest chance for success, the ASTB strides toward increasing diversity while maintaining low attrition. Using archived Student Naval Aviator and Student Naval Flight Officer ASTB subtest scores and Primary Flight Training (PFT) records, this study examined the ASTB's ... |
|
| Prostate Cancer Research Training in Health Disparities for Undergraduates (PCaRT) |
Mar 2011 |
165 pages |
| Authors:
Flora A Ukoli; MEHARRY MEDICAL COLL NASHVILLE TN
|
| Meharry faculty mentored five enthusiastic Fisk university students by providing training opportunities in ongoing research projects. Two students were rated as exceptional, two were excellent, and one was good. The two seniors applied for postgraduate positions. The students reported that the program met its training objectives but one student did not understand the objectives of the research project and one other student expected a lot more supervision than received. Four ... |
|
| Black Soldiers, Citizenship, and Constitutional Rhetoric: 1857-1866 |
23 Feb 2011 |
26 pages |
| Authors:
Michael C Miller; ARMY WAR COLL STRATEGIC STUDIES INST CARLISLE BARRACKS PA
|
| This paper evaluates the rhetoric surrounding military service by blacks in the Civil War, analyzing the rhetoric of political activists, most notable of whom was Frederick Douglas, and focusing on how they used newspapers, journals, and public speaking events to practice the ancient art of persuasion to build support for Civil War military service by blacks. The story of the Civil War, the end of slavery, and the journey from ... |
|
| Relationship between Depressive Symptoms and Cardiovascular Disease Risk Factors in African American Individuals |
2011 |
7 pages |
| Authors:
Ali A. Weinstein; Preetha Abraham; Guoqing Diao; Stacey A. Zeno; Patricia A. Deuster; GEORGE MASON UNIV FAIRFAX VA
|
| To examine the relationship between depressive symptoms and cardiovascular disease (CVD) risk factors in a group of African American individuals. Design. A nonrandom sample of 253 (age 43.7 ? 11.6 years; 37% male) African American individuals was recruited by advertisements. Data were obtained by validated questionnaires, anthropometric, blood pressure, and blood sample measurements. Results. Regression analyses were performed to assess the relationship between depressive symptoms and CVD risk factors controlling ... |
|
| Reducing Prostate Cancer Disparities through Behavioral and Biologic Epidemiologic Approaches |
SEP 2010 |
15 pages |
| Authors:
Bettina Drake; WASHINGTON UNIV ST LOUIS MO
|
| PURPOSE:This study seeks to define the optimal dose of vitamin D supplementation in Blacks needed for future intervention efforts in the prevention of prostate cancer. SCOPE: Study subjects were randomized to placebo, 1000IU, 2000IU, or 4000IU of vitamin D3 per day to determine the minimum dose of vitamin D needed to achieve an optimal level. After 3 months of supplementation, plasma levels of 25(OH)D and PSA are determined and compared ... |
|
| Differential Expression of Zinc Transporters in Prostate Epithelia of Racial Groups |
Sep 2010 |
21 pages |
| Authors:
Andre Kajdacsy-Balla; ILLINOIS UNIV AT CHICAGO
|
| In the award (W81XWH-08-1-0627) the stated goals are to study the zinc transporters that may be disparately expressed in the prostate tissues of African American (AA) males as compared to European American (EA) males. This may lead to identification of the potential molecular targets for preventive or therapeutic measures or nutritional, environmental or life style factors for their potential relationship to the incidence or progression of prostate cancer in various ... |
|
| Collaboration Around Research and Education (CARE) in Prostate Cancer |
AUG 2010 |
49 pages |
| Authors:
Marva Price; DUKE UNIV DURHAM NC
|
| Collaboration around Research and Education (CARE) was a partnership funded by the United States Department of Defense between two academic programs, Duke University School of Nursing (Duke) and Bennett College for Women (Bennett), an historically black college or university (HBCU). We had success across three years in our collaborative relationship. We matched underrepresented minority women students to faculty mentors to facilitate opportunities to study prostate cancer. CARE was marketed by ... |
|
| Glycomic Analysis of Prostate Cancer |
JUL 2010 |
7 pages |
| Authors:
Radoslav Goldman; GEORGETOWN UNIV WASHINGTON DC
|
| In this proposal, we are testing the hypothesis that the risk of developing prostate cancer and the aggressiveness of the disease are influenced by protein glycosylation. We postulate that glycobiology contributes to the higher susceptibility of African American men. The study population is assembled and an annotated sample repository is ready for use. Methods for the glycomic analysis of fractionated proteins are in place. We are evaluating mRNA datasets comparing ... |
|
| Prostate Cancer Research Training Program |
Jun 2010 |
5 pages |
| Authors:
David Lubaroff; IOWA UNIV IOWA CITY
|
| The Historically Black Colleges and Universities (HBCU) Summer Research Training Program accepted a total of 8 students from Lincoln University for the eight-week session during the summer of 2009. One student canceled at the last minute, leaving 7 students in the program. Three of the students were supported by the original grant, awarded in 2006, and four of the students were supported by the second grant, which was awarded in ... |
|
| Developing Breast Cancer Program at Xavier; Genomic and Proteomic Analysis of Signaling Pathways Involved in Xenohormone and MEK5 Regulation of Breast Cancer |
May 2010 |
36 pages |
| Authors:
Thomas E Wiese; XAVIER UNIV OF LOUISIANA NEW ORLEANS
|
| Xavier University (XU) and the Tulane Cancer Center (TCC) will build a core of human talent that will address scientific problems such as drug resistance and the effect of environmental agents on breast cancer (BC) in the African- American community. A multi-part research and training program will generate data, develop new research programs and train new faculty and African-American students in BC research. The first component will fund two research ... |
|
| Prevalence and Factors Associated with Renal Dysfunction Among HIV-Infected Patients |
Jan 2010 |
11 pages |
| Authors:
Nancy Crum-Cianflone; Anuradha Ganesan; Nimta Teneza-Mora; Mark Riddle; Sheila Medina; Irma Barahona; Stephanie Brodine; NAVAL MEDICAL CENTER SAN DIEGO CA
|
| Renal dysfunction is an increasingly recognized non-AIDS--defining comorbidity among HIV -infected persons. The role of HIV-related factors in renal dysfunction remains unclear. We performed a cross-sectional study at two military clinics with open access to care to determine the impact of HIV factors, including antiretroviral therapy, on renal function. Renal dysfunction was defined as a glomerular filtration rate (GFR) 60 mL/min/ 1.73 m . We evaluated 717 HIV patients ... |
|
| Prostate Cancer in African-American Men: Serum Biomarkers for Early Detection Using Nanoparticles |
NOV 2009 |
62 pages |
| Authors:
Catherine M. Phelan; H LEE MOFFITT CANCER CENTER AND RESEARCH INST TAMPA FL
|
| We have collected blood samples from 65 African-American men with prostate cancer and 80 ethnically matched control healthy men with questionnaire data on demographics, general health and cancer family history. We chose six biomarkers PSA, KLK2, KLK14, IL6, CAV-1, anti-p53 antibody and OPG as candidates for improved early detection of prostate cancer in plasma from the African American men with and without prostate cancer. We had technical problems with KLK2 ... |
|
| Creatine Kinase Clinical Considerations: Ethnicity, Gender and Genetics |
Oct 2009 |
14 pages |
| Authors:
Patricia A Deuster; Francis G O'Connor; Kimbra Kenney; Yuval Heled; Sheila Muldoon; Carmen Contreras-Sesvold; William W Campbell; UNIFORMED SERVICES UNIV OF THE HEALTH SCIENCES BETHESDA MD DEPT OF MILITARY AND EMERGENCY MEDICINE
|
| Exertional rhabdomyolysis (ER), or breakdown of skeletal muscle during exercise, is a potentially life-threatening event. ER can affect Warfighters in multiple settings, yet approaches for identifying persons susceptible to or at risk for ER have not been identified. Despite marked variability in baseline serum creatine kinase (CK), individual CK values are typically used to both diagnose and manage ER. Factors that may affect CD include ethnicity, gender, and genetics. One ... |
|
| Benign Breast Disease: Toward Molecular Prediction of Breast Cancer Risk |
Jun 2009 |
150 pages |
| Authors:
Lynn C Hartmann; MAYO CLINIC ROCHESTER MN
|
| Optimal early detection and prevention strategies for breast cancer are predicated on our ability to identify individuals at significantly increased risk for this disease. The purpose of this Center was to bring molecular risk prediction for breast cancer into the clinical arena. The three areas of scientific inquiry included:(i) Establishment of a tissue repository of benign breast disease; (ii) Assessment of potential biomarkers of risk in this tissue set and ... |
|
| Contribution of AMACR and Phytanic Acid to Prostate Cancer Risk Among African Americans in North Carolina |
May-2009 |
15 pages |
| Authors:
Jienfeng Xu; WAKE FOREST UNIV WINSTON-SALEM NC SCHOOL OF HEALTH SCIENCES
|
| Several lines of evidence have suggested genetic and dietary differences may be important in PCa, particularly among AA (African American) men. In this study, we aimed to test the hypothesis that mutations/sequence variants in the AMACR gene, and dietary intake of foods rich in phytanic acid, increase the risk to PCa among AA men. We conducted a population based study by ascertaining 213 AA men who have PCa and 264 ... |
|
| Prairie View A&M/Baylor College of Medicine SMART Summer Undergraduate Prostate Cancer Research Project |
Apr-2009 |
8 pages |
| Authors:
Nancy L Weigel; B G Slaughter; BAYLOR COLL OF MEDICINE HOUSTON TX
|
| The goal of this project is to encourage undergraduates to enter careers in prostate cancer research. This project involves BCM faculty presentations at Prairie View A & M University and a 9 week summer prostate cancer research experience at BCM for up to 5 undergraduates/year from PVAMU (3 in 2006; 4 in 2007 and 2008). Participants attended a weekly research discussion group focused on prostate cancer. Students make PowerPoint presentations ... |
|
| Genetic Association Study of Ancestry-Matched African American Prostate Cancer Cases and Control |
Apr-2009 |
10 pages |
| Authors:
William B Isaacs; JOHNS HOPKINS UNIV BALTIMORE MD
|
| African American men have the highest incidence and mortality from prostate cancer in the world. Multiple reasons have been postulated to explain these findings although the definitive reasons for this are unknown. While both environmental and genetic factors may contribute to prostate cancer susceptibility, results from multiple studies consistently implicate a strong genetic component of this cancer. However, a specific gene which is consistently and reproducibly associated with prostate cancer ... |
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Reports by Keyword(s)
AFRICAN AMERICANS
