| Molecular Mechanism for Prostate Cancer Resistance to the Anti-tumor Activity of Vitamin D |
NOV 2006 |
51 pages |
| Authors:
Larisa Nonn; LELAND STANFORD JUNIOR UNIV STANFORD CA
|
 | The original purpose of this research, as proposed in the statement of work, was to determine the mechanism by which prostate cancer (PCa) cells become resistant to the anti-tumor activity of vitamin D. The proposal focused on a PCa-specific deficiency in a key vitamin D metabolizing enzyme, 1alpha-hydroxylase (1alphaOH). During the first year, we encountered unforeseen difficulties with one of the key techniques in the original proposal. Therefore we decided ... |
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| Pim-1: A Molecular Target to Modulate Cellular Resistance to Therapy in Prostate Cancer |
OCT 2006 |
29 pages |
| Authors:
Michael B. Lilly; LOMA LINDA UNIV CA
|
| The contract supports studies to define the role of the Pim-1 kinase in acquired resistance to chemotherapy by prostate cancer cells. Data to date for specific aim #1 define a signaling pathway induced by docetaxel, involving sequential steps of JAK1/2 activation, STAT3 phosphorylation, expression of Pim-1, and activation of NFkB signaling. Blockade of this pathway by expression of dominant negative Pim-1 proteins blocks drug-induced upregulation of NFkB activity, and sensitizes ... |
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| NMCI: History, Implementation, and Change |
01 SEP 2006 |
201 pages |
| Authors:
Gregory S. Taylor; NAVAL POSTGRADUATE SCHOOL MONTEREY CA
|
| In October of 2000, the Navy's leadership entered a multi-billion dollar IT service contract with a private company to build and maintain the Navy-Marine Corps Intranet (NMCI). The hope was to have the new intranet fully operational in just two years, but the program encountered so many difficulties that, almost six years later, the initial implementation process is still underway. Aside from the unexpectedly high number of applications that needed ... |
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| Numerical Evaluation of Stress Intensity Factors (Ki) J-Integral Approach |
SEP 2006 |
11 pages |
| Authors:
Guillermo A. Riveros; ENGINEER RESEARCH AND DEVELOPMENT CENTER VICKSBURG MS
|
| The purpose of this Coastal and Hydraulics Engineering Technical Note (CHETN) is to describe the numerical evaluation of the stress intensity factors using the J-integral approach (Rice 1968a, 1968b). The stress intensity factors have been calculated for a semi-infinite plate with an edge crack. This case has a known closed-form solution, and only a 1.25 percent difference between the numerical and closed-form solution was obtained. This CHETN also presents the ... |
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| Mathematical Modeling of Rail Gun |
SEP 2006 |
99 pages |
| Authors:
Nikolaos Pratikakis; NAVAL POSTGRADUATE SCHOOL MONTEREY CA
|
| The exit velocity of the launch object along with the values of electric and thermal conductivity at the interfaces between the rails and the armature of a rail gun are critical issues. This thesis, using finite element method, estimates the former by solving the proper multiphysics governing equations along with exploiting the contact theory between flat surfaces. A parametric analysis in the vicinity of the standard deviation of the normalized ... |
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| Measures of Effectiveness: Israeli Counterterrorism Strategies and Tactics During the Al-Aqsa Intifada |
SEP 2006 |
93 pages |
| Authors:
Diane L. Maye; NAVAL POSTGRADUATE SCHOOL MONTEREY CA
|
| On September 28, 2000, Israel's Likud party leader, Ariel Sharon, visited the Temple Mount in the Old City of Jerusalem. His visit spawned the al-Aqsa Intifada, a period of significant Palestinian resistance that has never "officially" ended, and whose reverberations continue to be felt to this day. This thesis assesses Israel's counter-terror strategies and tactics during the al-Aqsa Intifada in light of established scholarly measures of effectiveness. It focuses on ... |
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| HPAC (Hazard Prediction and Assessment Capability) jSWAT (Joint Seminar Wargaming Adjudication Tool) Integration; A Technical Solution |
SEP 2006 |
|
| Authors:
Matt Brennan; Alex Skvortsov; Ralph Gailis; DEFENCE SCIENCE AND TECHNOLOGY ORGANISATION VICTORIA (AUSTRALIA) HUMAN PROTECTION AND PERFORMANCE DIV
|
 | This paper provides an outline of the technical solution to be adopted when integrating the Hazard Prediction and Assessment Capability (HPAC) with DSTO's Joint Seminar Wargaming Adjudication Tool (jSWAT). Opportunities to conduct "least path of resistance" integration between the two applications are explored to support an eventual Proof of Concept demonstration. The report concludes with some observations on achievable longer term integration goals. |
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| Adhesion Measurements of Thin Films in Corrosive Environments |
SEP 2006 |
16 pages |
| Authors:
Alex A. Volinsky; Patrick Waters; UNIVERSITY OF SOUTH FLORIDA TAMPA DEPT OF MECHANICAL ENGINEERING
|
| With the use of thin films reaching a wide variety of applications, it is important to know how thin films will hold up in a variety of environmental conditions. Here, water effects on thin film adhesion were studied on copper and diamond like carbon (DLC) films. Regardless of the film being considered, it is usually advantageous to have a thin film that adheres well to its substrate. Because of the ... |
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| Targeting Mechanisms of Resistance to Taxane-Based Chemotherapy |
SEP 2006 |
15 pages |
| Authors:
Chung-Yung Huang; FRED HUTCHINSON CANCER RESEARCH CENTER SEATTLE WA
|
| Patients with high-risk localized prostate cancer have a high recurrence rate following primary therapy. Neoadjuvant chemotherapy has been shown to be beneficial in reducing recurrence rates in some tumor types, but has yet to be of proven benefit in prostate cancer. Further, current clinical, pathological and molecular markers poorly predict the response and resistance of chemotherapy, and the molecular mechanisms of chemotherapy resistance are largely unknown. We utilized tissue resources ... |
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| Beta-catenin: A Potential Survival Marker of Breast Cancer Stem Cells |
SEP 2006 |
112 pages |
| Authors:
Jeffrey M. Rosen; Mercy S. Chen; BAYLOR COLL OF MEDICINE HOUSTON TX
|
| The Wnt/ -catenin pathway has been extensively studied for its role in development and cancer. The canonical Wnt signal is transduced by -catenin, which acts as a transcriptional coactivator by associating with the Tcf/LEF family of transcription factors. It has been established that Wnt signaling regulates the self-renewal of normal stem cells in both the hematopoietic systems and the epidermis. In addition, constitutive activation of the Wnt pathway has been ... |
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| The Influence of Armor Material Parameters on the Penetration by Long-Rod Projectiles |
SEP 2006 |
12 pages |
| Authors:
William P. Walter; Cyril L. Williams; ARMY RESEARCH LAB ABERDEEN PROVING GROUND MD WEAPONS AND MATERIALS RESEARCH DIRECTORATE
|
| The Alekseevski-Tate equations have long been used to predict the penetration, penetration velocity, rod velocity, and rod erosion of long-rod projectiles or kinetic energy penetrators (1). These nonlinear equations were originally solved numerically, then by the exact analytical solution of Walters and Segletes (2, 3). However, due to the nonlinear nature of the equations, the penetration was obtained implicitly as a function of time, so that an explicit functional dependence ... |
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| Role of the Neddylation Enzyme Uba3, A New Estrogen Receptor Corepressor in Breast Cancer |
SEP 2006 |
131 pages |
| Authors:
Kenneth P. Nephew; Meiyun Fan; Teresa Craft; Annie Park; INDIANA UNIV AT BLOOMINGTON SCHOOL OF MEDICINE
|
| Estrogens play important roles in both the onset and malignant progression of breast cancer. The content of estrogen receptors in breast tumors is a valuable predictor of whether a patient will respond to therapy with antiestrogens, such as tamoxifen and fulvestrant (ICI 182,780). Expression and activity of ER can be lost or impaired in antiestrogen-resistant breast cancer. The proposed studies are designed to test the overall hypothesis that the ubiquitin-like ... |
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| Overcoming Bone Marrow-Stroma-Mediated Chemoresistance in Metastatic Breast Cancer Cells |
AUG 2006 |
30 pages |
| Authors:
Robert Wieder; UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY NEWARK
|
| Mammary ductal integrity is lost during dedifferentiation to cancer. Ductal morphogenesis has been reported to depend on expression of FGF-2 and laminin 5. We demonstrate that the two proteins are coordinately lost during the progression to cancer and that FGF-2 may contribute to the deposition of Laminin 5. Breast cancer cells metastasize to the bone marrow early during cancer formation where they can remain dormant for years and are resistant ... |
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| Experimental Characterization of Nonlinear Viscoelastic and Adhesive Properties of Elastomers |
27 JUL 2006 |
78 pages |
| Authors:
K. Ravi-Chander; R. S. Barsoum; TEXAS UNIV AT AUSTIN CENTER FOR MECHANICS OF SOLIDS STRUCTURES AND MATERIALS
|
| This report describes the characterization of the viscoelastic properties of polyurea and the failure of ductile materials at high strain rates. The mechanical properties of polyurea were determined under monotonic loading conditions, both in the unconfined and confined compression configurations. Direct measurements of the volumetric and shear response has been used to show that the shear resistance is nearly negligible, while the bulk modulus increases significantly with pressure. Expanding ring ... |
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| Centrosome Amplification: A Potential Marker of Breast Cancer Agressiveness |
JUL 2006 |
37 pages |
| Authors:
Antonino B. D'Assoro; MAYO CLINIC ROCHESTER MN
|
| The aim of our research is focused in elucidating the mechanisms by which the normal regulatory pathways coordinating centrosome duplication with cell cycle events may become uncoupled promoting breast cancer development, progression, chemoresistance and consequent poor outcome. The preliminary results reported in this grant suggest that the development and progression of breast cancer is a complex process involving the role of estrogens, growth factor signaling pathways and abrogation of the ... |
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| A Tamper-Resistant Programming Language System |
02 JUN 2006 |
24 pages |
| Authors:
Dennis Heimbigner; COLORADO UNIV AT BOULDER DEPT OF COMPUTER SCIENCE
|
| An important and recurring security scenario involves the need to carry out trusted computations in the context of untrusted environments. It is shown how a tamper-resistant interpreter for a programming language -- currently Lisp 1.5 -- combined with the use of a secure co-processor can address this problem. This solution executes the interpreter on the secure co-processor while the code and data of the program reside in the larger memory ... |
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| Should your Projects' Leaders be on Springer? |
01-Jun-2006 |
3 pages |
| Authors:
Paul Kimmerly; MARINE CORPS TECHNOLOGY SERVICES ORGANIZATION KANSAS CITY MO
|
| This issue of CrossTalk focuses on software projects that fail. Process improvement programs can help a software program succeed. They can also help it fail. Process improvement programs face a number of challenges within an organization. These challenges can include fickle or uncaring sponsors, strange behavior, and process envy. Such dysfunctional behaviors reflect the personalities and culture of the organization. Any organization is a miniature version of society as a ... |
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| Ungoverned Spaces: The Challenges of Governing Tribal Societies |
JUN 2006 |
151 pages |
| Authors:
Ty L. Groh; NAVAL POSTGRADUATE SCHOOL MONTEREY CA
|
| This thesis addresses the efforts of different regimes to establish their authority over the Pashtun ethnic group. The Pashtun are at the heart of the conflict in Afghanistan, which also reaches into northwestern Pakistan. They provide a current example of why "ungoverned spaces" -- geographic regions beyond the reach of central authority -- have become such an important topic among many of the world's countries. People who exist within a ... |
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| Low Voltage Electrolytic Capacitor Pulse Forming Inductive Network for Electric Weapons |
JUN 2006 |
63 pages |
| Authors:
Thomas A. Mays; NAVAL POSTGRADUATE SCHOOL MONTEREY CA
|
| Electric weapons, such as the railgun, require a pulse power supply capable of providing reliable high-current, high-energy pulses of many megawatts. Pulsed alternators potentially have the same maintenance issues as other motor-generator sets, so a solid-state system would be desirable, but high voltage capacitor systems are not robust enough for the field. We propose here a Low Voltage Electrolytic Capacitor Pulse Forming Inductive Network (LVEC PFIN) which stores power in ... |
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| Effects of Herstatin, an Alternative HER-2 (erbB-2) Product, on Hormonal Responsiveness of Breast Cancer |
JUN 2006 |
9 pages |
| Authors:
Gail M. Clinton; OREGON HEALTH AND SCIENCE UNIV PORTLAND
|
| The HER-2 receptor tyrosine kinase (erbB-2) and the estrogen receptor (ER) participate in the establishment and progression of breast cancer. While the anti-estrogen tamoxifen is used as a therapeutic resistance is a clinical problem. Over expression of HER-2 confers resistance to the antiestrogen tamoxifen. The objective was to evaluate the effects of Herstatin a naturally occurring inhibitor of the HER-2 receptor on hormonal responsiveness of breast cancer cells. scope. The ... |
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| A New Silicon-Containing Bis(Cyanate) Ester Resin with Improved Thermal Oxidation and Moisture Resistance |
23 MAY 2006 |
35 pages |
| Authors:
Andrew J. Guenthner; Gregory R. Yandek; Michael E. Wright; Brian J. Petteys; Roxanne Quintana; Dan Connor; Richard D. Gilardi; Darrell Marchant; NAVAL AIR SYSTEMS COMMAND CHINA LAKE CA
|
| A new cyanate ester monomer was prepared from bis(4-cyanatophenyl)-dimethylsilane (SiMCy) and fully characterized by analytical and spectroscopic techniques. The monomer was found to have a melting point about 20 deg C lower than that of the commercial bis(4-cyanatophenyl)dimethylmethane (BADCy) with similar melt viscosity, curing kinetics, and post-cure glass transition temperature. Analysis of the single-crystal molecular structure by x-ray diffraction showed that intermolecular packing was dominated by weak hydrogen-bonding attractions between ... |
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| Mechanisms of Chemoresistance in Breast Cancer Cells |
MAY 2006 |
17 pages |
| Authors:
Valerie Gouaze; JOHN WAYNE INST FOR CANCER TREATMENT AND RESEARCH SANTA MONICA CA
|
| The objective of this second year was to determine whether anticancer agents influence the expression of glucosylceramide synthase (GCS). GCS is an enzyme which catalyzes ceramide glycosylation and is associated with chemotherapy resistance in cancer cells. Drugs like doxorubicin, cisplatin, etoposide, and taxol cells had no effect on glucosylceramide (GC) mass production in MCF-7 after short-term exposure (30 min-4 hr). After 24 hr, only taxol induced significant GC production. In ... |
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| Effect of Substrate Thickness on Exploding Films |
May-2006 |
5 pages |
| Authors:
J Zirnheld; S Olabisi; P Strzempka; A Halstead; B Urbanczyk; H Moore; STATE UNIV OF NEW YORK AT BUFFALO ENERGY SYSTEMS INST
|
| The exploding wire phenomenon is well researched due to its vast and practical applications which include, but are not limited to, shock wave generation, pulsed power, Z pinch physics, plasma ignition, fuses, and fusing applications. However, the focus of this research is on a surrogate for exploding wires. In this research, metallized capacitor grade-polypropylene film was used as an alternative for the traditional wire of a uniform diameter. The films ... |
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| Blast Retrofit Design of CMU Walls Using Polymer Sheets |
MAY 2006 |
103 pages |
| Authors:
Silas J. Fitzmaurice; Hani Salim; Robert J. Dinan; Elizabeth Trawinski; MISSOURI UNIV-COLUMBIA DEPT OF CIVIL ENGINEERING
|
| The research presented in this thesis details the development of analytical modeling and experimental evaluation of CMU-polymer walls to blast loading. Polymer sheets were analyzed as a method for retrofit design. This research was done to ascertain the strength, ductility, response to static pressure, investigate connection details, and develop an analytical model of the static resistance function. The analytical model developed for the static resistance was used in a SDOF ... |
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| Exploiting the Innate Antitumor Activity of Human gammadelta-TCells for the Treatment of Prostate Cancer |
APR 2006 |
28 pages |
| Authors:
Richard Lopez; ALABAMA UNIV IN BIRMINGHAM
|
| We initially identified a CD2-mediated, interleukin (IL)-12 dependent signaling pathway which inhibits apoptosis in mitogen-stimulated human gamma/delta T-cells. We have since exploited this pathway to develop the methodologies allowing the large-scale ex vivo expansion of viable apoptosis-resistant - T cells. We have shown that apoptosis-resistant human T- cells retain significant innate, major histocompatibility complex (MHC)-unrestricted cytotoxicity against human prostate cancer cell lines. Purpose and scope: The aims of this project ... |
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| Significance of Pathways Leading to RhoC Overexpression in Breast Cancer |
APR 2006 |
46 pages |
| Authors:
Sharon Hensley-Alford; MICHIGAN UNIV ANN ARBOR
|
| Tumor biology is a recognized determinant of tumor behavior, including growth rate, motility and metastatic potential, and therapeutic resistance. This project was funded to investigate the regulation and expression of an excellent marker for aggressive breast tumors: RhoC-GTPase. When overactive, RhoC transforms mammary epithelial cells into a highly motile and invasive phenotype. We hypothesize that RhoC overexpression may be regulated by the transcription factor NF-kappa B and that at the ... |
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| Inhibitors of Histone Deacetylases for Radiosensitization of Prostate Cancer |
APR 2006 |
9 pages |
| Authors:
Mira O. Jung; GEORGETOWN UNIV WASHINGTON DC
|
| Failure of conventional treatment of prostate cancer with radiotherapy may be due to intrinsic resistance of the tumor cells. One of mechanisms underlying intrinsic radiation sensitivity is linked to the state of chromatin architecture. The long-term goal of this proposal is to develop a novel therapeutic strategy by enhancing radiosensitivity of prostate cancer cells by testing the hypothesis that an increase of cellular radiation sensitivity may be achieved by exposure ... |
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| Chemical Modification of Fluorinated Polyimides: New Thermally Curing Hybrid-Polymers With POSS (PREPRINT) |
15 MAR 2006 |
33 pages |
| Authors:
Michael E. Wright; Brian J. Petteys; Andrew J. Guenthner; Stephen Fallis; Gregory R. Yandek; Sandra J. Tomczak; Timothy K. Minton; Amy Brunsvold; AIR FORCE RESEARCH LAB EDWARDS AFB CA
|
| A series of four new end-capped and hydroxymethyl-functionalized polyimides were prepared. Through a two-step chemical modification process 3- aminopropylisobutyl-POSS was covalently attached to the polymer backbone. POSS loading levels as high as 40 wt-% could be obtained while maintaining excellent processability and optical clarity of thin films. Concurrent attachment of either a cyanate ester or hydroxyethyl methacrylate (HEMA) group afforded processable POSS-polyimides that underwent thermal curing to yield solvent resistant ... |
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| Analysis of Bacterial Population and Distribution in the Developing Strata of a Constructed Wetland Used for Chlorinated Ethene Bioremediation |
MAR 2006 |
220 pages |
| Authors:
Jr Clausen Milton J.; AIR FORCE INST OF TECH WRIGHT-PATTERSON AFB OH SCHOOL OF ENGINEERING
|
| United States. These compounds attack the central nervous system in animals and can affect the photosynthesis of plants. These compounds are also resistant to degradation in the environment and, because of this, pose a risk to any ecosystem in which they are present. This study identified the dominant microbial species in a constructed treatment wetland at Wright-Patterson AFB, Dayton, Ohio using l6S rRNA gene sequence analysis. Samples were taken from ... |
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| A Multiscale Gradient Theory for Single Crystalline Elastoviscoplasticity |
FEB 2006 |
38 pages |
| Authors:
John D. Clayton; David L. McDowell; Douglas J. Bammann; ARMY RESEARCH LAB ABERDEEN PROVING GROUND MD WEAPONS AND MATERIALS RESEARCH DIRECTORATE
|
| Explicit volume averaging procedures are used to motivate a gradient-type description of single crystalline elastoviscoplasticity. Upon regarding local elastic and plastic deformation gradients within the crystal as continuously differentiable fields, we arrive at a three-term multiplicative decomposition for the volume-averaged deformation gradient, consisting of a recoverable elastic term associated with the average applied stress and average lattice rotation, an inelastic term associated with the average plastic velocity gradient, and a ... |
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| Phase I/II Trial of 13-Cis Retinoic Acid, Alpha Interferon, Taxotere, and Estramustine (R.I.T.E.) for the Treatment of Hormone Refractory Prostate Cancer |
FEB 2006 |
6 pages |
| Authors:
Robert S. DiPaola; Robert Weiss; W. J. Shih; UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY NEW BRUNSWICK
|
| Advanced prostate cancer is only temporarily controlled with androgen ablation therapy. In order to overcome tumor resistance we developed a epithelial cell line model to dissect out important mechanisms of resistance such as mutations in p53 and bcl-2 overexpression. In an attempt to sensitize these cells to paclitaxel (TAX) we found that 13-cis retinoic acid and alpha interferon (CRA/IFN) was capable of overcoming bcl-2 mediated resistance and reduced the expression ... |
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| Regulation of Calcium Fluxes and Apoptosis by BCL-2 Family Proteins in Prostate Cancer Cells |
FEB 2006 |
17 pages |
| Authors:
David J. McConkey; M D ANDERSON CANCER CENTER HOUSTON TX
|
| Members of the BCL-2 family of cell death regulators play critical roles in the progression of androgen-independent, metastatic prostate cancer. Despite years of research, the molecular mechanisms underlying the effects of these proteins remain unclear. In previous studies we demonstrated that BCL-2 family proteins regulate a crucial step in the apoptotic pathway (cytochrome c release) by regulating endoplasmic reticular and mitochondrial calcium fluxes. In this project we are studying these ... |
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| Performance of Polymer-Encased Concrete Walls Subjected to Blast Loads |
25 JAN 2006 |
12 pages |
| Authors:
James S. Davidson; Jeff W. Fisher; Robert J. Dinan; ALABAMA UNIV IN BIRMINGHAM
|
| This paper discusses recent testing and finite element simulation of stay-in-place polymer concrete forms. Static tests provided a definition of resistance mechanisms. Dynamic tests demonstrated improved blast resistance effectiveness over other standard concrete wall forms. The finite element simulations provide a high level of understanding of resistance mechanisms, fracture propagation, influence of support conditions, etc., over the duration of the flexural response. The knowledge gained from the testing and simulation ... |
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| The Effects of the Draft on U.S. Presidential Approval Ratings During the Vietnam War, 1954-1975 |
2006 |
227 pages |
| Authors:
Brett E. Morris; AIR FORCE INST OF TECH WRIGHT-PATTERSON AFB OH
|
| A gap exists in understanding and modeling the Vietnam War era for lack of qualitative studies into the political effect of the military draft. Using presidential approval ratings as a proxy assessment of the country's well-being and political strength, this work seeks to fill the void by evaluating the effects of the Vietnam-era draft on presidential approval between 1954 and 1975. With a basis in rational theory, it uses Autoregressive ... |
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| Voltage-Induced Insulator-Metal Transition at Room Temperature in an Anodic Porous Alumina Thin Film |
2006 |
5 pages |
| Authors:
S. Kato; S. Nigo; Y. Uno; T. Onisi; G. Kido; NATIONAL INST FOR MATERIALS SCIENCE TSUKUBA IBARAKI (JAPAN) NANO-MATERIALS LAB
|
| Bistable switching effect, induced by an electric field, in an anodic porous alumina thin film is reported. An electrode was bonded on the surface of a thin film with Ag paste, and I-V characteristic between the electrode and the aluminium substrate was measured The I-V characteristic reveals a reversible resistance change, initiating at +4 V and terminating at 1.5 V at room temperature. Huge electrical resistance change ratio (RR), defined ... |
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| Resistance Tests of a Systematic Series of U.S. Coast Guard Planing Hulls |
DEC 2005 |
66 pages |
| Authors:
Bryson J. Metcalf; Lisa Faul; Elissa Bumiller; Jonathan Slutsky; NAVAL SURFACE WARFARE CENTER CARDEROCK DIV BETHESDA MD
|
| Resistance experiments were performed on a systematic series of models based on the United States Coast Guard 47-foot Motor Lifeboat (MLB) hull form. The series includes three models with varying length-to-beam ratios and one model with transom dead-rise angle variation. Resistance tests were completed on each model for a range of conditions, with displacements varying from 298 Ibs to 680 Ibs and longitudinal center of gravity located at 38% and ... |
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| What Lies Beneath: Saddam's Legacy and the Roots of Resistance in Iraq |
DEC 2005 |
149 pages |
| Authors:
Peter J. Munson; NAVAL POSTGRADUATE SCHOOL MONTEREY CA
|
| Saddam Hussein's patrimonial coercive rule reshaped major aspects of the Iraqi state and society, providing structures and motivations that have fueled resistance in the wake of regime change. By linking literature describing the effects of Ba'ath rule on the Iraqi state, society, and individual to the characteristics and motivations of the resistance, a more nuanced understanding of the complex landscape of Iraqi transition is possible. Repressive regimes produce a lasting ... |
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| Simulation of Hydrodynamic Forces and Motions for a Freely Maneuvering Ship in a Seaway |
DEC 2005 |
|
| Authors:
Kevin McTaggart; DEFENCE RESEARCH AND DEVELOPMENT ATLANTIC DARTMOUTH (CANADA)
|
| ShipMo3D is DRDC Atlantic's object-oriented library for modelling ship motions in waves. Previous ShipMo3D development considered ships travelling with nominally steady speed and heading. This report describes the extension of the ShipMo3D library to model motions of freely maneuvering ships. New ShipMo3D force components arise from hull maneuvering, resistance, propulsion, and rudder-propeller interaction. Comparisons of turning circle predictions with full-scale trials data for the tanker Esso Osaka give encouraging results. ... |
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| Polymer Nanocomposites Designed with Polyhedral Oligomeric Silsesquioxanes (POSS) and Plastics |
22 NOV 2005 |
2 pages |
| Authors:
Timothy Haddad; Joseph Mabry; AIR FORCE RESEARCH LAB EDWARDS AFB CA PROPULSION DIRECTORATE
|
| Polyhedral oligomeric silsesquioxanes (POSS) are nanoparticles that are used to enhance the thermal and mechanical properties of polymeric systems and are being examined for use in many applications. These applications include space-survivable coatings and fire-resistant materials. Due to their physical size, POSS incorporation in polymers generally serves to reduce chain mobility, thus affecting both thermal and mechanical properties. Polymeric materials are typically tough, lightweight, and easy to process. However, they ... |
|
| The Effect of Glycolytic Modulation on Prostate Cancer |
NOV 2005 |
5 pages |
| Authors:
Robert S. DiPaola; UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY NEWARK
|
| In this proposal, we focus on, and have preliminary data to support, a novel approach targeting metabolism (by inhibition of glycolysis) to compliment ongoing clinical efforts to abrogate growth factor and apoptotic pathways in prostate cancer. The proposed clinical and laboratory studies are relevant to prostate cancer, given preliminary data demonstrating the importance of modulation of the glycolytic pathway in prostate cancer cell lines independent of activation of Akt and ... |
|
| The Efficacy of the Czech Original Prophylactic Mixture, Called Panpal, as Pharmacological Pretreatment of Tabun or Soman-Poisoned Rats and Mice |
01 OCT 2005 |
8 pages |
| Authors:
Jiri Kassa; Josef Fusek; Gabriela Krejcova; Lucie Sevelova; Jiri Bajgar; PURKYNE MILITARY MEDICAL ACADEMY HRADEC KRALOVE (CZECH REPUBLIC)
|
| The potency of the Czech original pharmacological pretreatment consisting of pyridostigmine, benactyzine and trihexyphenidyle, designated PANPAL, to increase the resistance of rats and mice against tabun or soman and to increase the therapeutic efficacy of standard antidotal treatment of tabun or soman-poisoned experimental animals was studied and compared with commonly used pyridostigmine alone. While PANPAL significantly increased the resistance of animals against tabun or soman and increased the efficacy of ... |
|
| Breast Cancer Specific Gene 1 is a Potential Novel Biomarker for Selected Application of Anti-Microtubule Drugs for the Treatment of Breast Cancer Patients |
OCT 2005 |
11 pages |
| Authors:
Jingwen Liu; VETERANS AFFAIRS PALO ALTO HEALTH CARE SYSTEM CA
|
| Anti-microtubule drugs that cause mitotic arrest and subsequent apoptosis of cancer cells are frequently used to treat breast cancer patients with advanced or metastatic diseases. However, patient response rates to this class of chemotherapeutic agents vary significantly. Identification of cellular and genetic factors that are associated with the sensitivity to anti-microtubule drug treatment would be of great clinic implications. Our previous studies have demonstrated that the neuronal protein synuclein-gamma (SNOG), ... |
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| Androgen Receptor-Mediated Escape Mechanisms from Androgen Ablation Therapy |
OCT 2005 |
106 pages |
| Authors:
Gerherd A. Coetzee; Judd Rice; Li Jia; CALIFORNIA STATE UNIV LOS ANGELES
|
| Too many prostrate-cancer treatments, especially those relying on the suppression ofandrogen, eventually fail to slow the advance of the disease. One explanation for this situation is the absence of any systematic knowledge on the role and function of the androgen receptor (AR) in the course of prostrate cancer development. Recent findings indicate that the AR is the key master regulator that determines disease progression to androgen independence, which ultimately contributes ... |
|
| Numerical Simulation of Galvanic Corrosion Caused by Shaft Grounding Systems in Steel Ship Hulls |
07 SEP 2005 |
|
| Authors:
Y. Wang; DEFENCE RESEARCH AND DEVELOPMENT ATLANTIC DARTMOUTH (CANADA)
|
| The shaft grounding systems used on board HMC ships have substantially reduced the shaft-to-hull resistance and, thus, improved the performance of the shipboard impressed current cathodic protection (ICCP) system. Under some circumstances, however, the shaft grounding systems have been left on while the ICCP system was turned off. This led to the accelerated corrosion of the exposed steel ship hull on paint holidays because of the substantial difference of the ... |
|
| Preparing Military Officers for Effective Service in an Inter-Agency Environment |
SEP 2005 |
116 pages |
| Authors:
Clifford A. Nancarrow; NAVAL POSTGRADUATE SCHOOL MONTEREY CA
|
| This thesis evaluates, through the lens of the 1986 Goldwater-Nichols Act, training and assignment policy alternatives for expediting the development and deployment of military officers to fill billets requiring interagency expertise. Using the United States Northern Command (USNORTHCOM) as a case study, it examines these policy alternatives and proposes Joint Mission Essential Tasks (JMETs) that might form the basis for required training and education. It proposes the establishment of a ... |
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| Association Between Microtubule Associated Protein -2 and the EGRF Signaling in Breast Cancer |
SEP 2005 |
11 pages |
| Authors:
Vaqar M. Adhami; WISCONSIN UNIV-MADISON
|
| Microtubule associated proteins (MAP)-2 a component of the MAP family, is a marker for neurons and its immunoreactivity has been demonstrated in several neoplasms. We hypothesized that MAP-2 expression is deregulated in EGFR overexpressing breast cancers thus rendering them resistant to conventional therapy. Here we show that loss of MAP-2 expression in breast cancer cells during sustained activation of the EGFR results in resistance to chemotherapeutic drugs. We observed higher ... |
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| Thermomechanical Behavior of Monolithic SN-AG-CU Solder and Copper Fiber Reinforced Solders |
SEP 2005 |
71 pages |
| Authors:
Rolando Reuse; NAVAL POSTGRADUATE SCHOOL MONTEREY CA DEPT OF MECHANICAL AND ASTRONAUTICAL ENGINEERING
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| Solder joints provide both electrical and mechanical interconnections between a silicon chip and the packaging substrate in an electronic application. The thermomechanical cycling in the solder causes numerous reliability challenges, mostly because of the mismatch of the coefficient of thermal expansion between the silicon chip and the substrate. The actual transition to lead-free solders and the trend towards hotter-running, miniaturized and higher current density chips aggravate this situation. Therefore, improved ... |
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| Characterization of Breast Cancer Stem Cells. Addendum |
AUG 2005 |
14 pages |
| Authors:
David L. Crowe; UNIVERSITY OF SOUTHERN CALIFORNIA LOS ANGELES
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| Cellular markers which identify putative breast epithelial stem cells have been reported. Certain clinical aspects of breast cancer could result from transformed stem cells in the malignant tumor. Breast cancer may therefore originate from neoplastic transformation of normal breast epithelial stem cells. These transformed stem cells exist in the tumor as rare cells with properties that drive aspects of tumorigenesis. This model predicts slower cell cycle progression, greater resistance to ... |
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| Food Commensals as a Potential Major Avenue in Transmitting Antibiotic Resistance Genes |
AUG 2005 |
26 pages |
| Authors:
Mark W. Lehman; Hua H. Wang; Michele Manuzon; Kai Wan; Hongliang Luo; Tom Wittum; Ahmed Yousef; Lauren O. Bakaletz; OHIO STATE UNIV COLUMBUS
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| The rapid emergence of antibiotic resistant (ART) pathogens is a major threat to public health. While the surfacing of ART foodborne pathogens is alarming, the magnitude of the antibiotic resistance (AR) gene pool in foodborne commensals is yet to be revealed. Incidence of ART commensals in dairy, meat, seafood and produce products was examined in this study. Twelve of the 15 retail cheese samples tested were found to contain Tet ... |
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| Molecular Mechanisms of Metastatic Progression in Breast Cancer |
31 JUL 2005 |
22 pages |
| Authors:
Louise Flanagan; NOTRE DAME UNIV IN DEPT OF BIOLOGICAL SCIENCES
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| Clusterin is a secreted glycoprotein that is upregulated in a variety of cell lines in response to stress, and enhances cell survival. A second nuclear isoform of clusterin that is associated with cell death has also been identified. The aim of this study was to determine the role(s) of secretory isoform in breast tumor progression and metastasis. To investigate the role of secretory clusterin the biology of breast cancer tumor ... |
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