| Methylation of Liver DNA Guanine in Hamsters Given Hydrazine |
1983 |
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| Authors:
W. S. Bosan; R. C. Shank; CALIFORNIA UNIV IRVINE
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| Chemical Carcinogen-Induced Changes in tRNA Metabolism in Human Cells |
NOV 1982 |
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| Authors:
Ronald W. Trewyn; OHIO STATE UNIV RESEARCH FOUNDATION COLUMBUS
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 | It was demonstrated that the nucleic acid catabolite 7-methylguanine (a major product of many carcinogen methylation reactions as well as a natural component of RNA) modulates tRNA modification by inducing queuine hypomodification. Phorbol ester tumor promoters were found to induce similar TRNA changes immediately preceding major phenotypic alterations in cultured human cells. Culture conditions were defined which allow normal human cells to mimic in vitro transformation in the continuous presence ... |
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| Comparative Biochemistry and Metabolism. Part I. Carcinogenesis |
AUG 1982 |
30 pages |
| Authors:
Ronald C. Shank; Richard A. Becker; William S. Bosan; CALIFORNIA UNIV IRVINE DEPT OF COMMUNITY AND ENVIRONMENTAL MEDICINE
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 | The inorganic reducing agent, hydrazine, is toxic and weakly carcinogenic. In earlier studies it was found that oral administration of a toxic dose of hydrazine to the rat resulted in methylation of liver DNA guanine moieties with an apparent dependency upon endogenous S-adenosylmethionine as the source of the methyl group. Further studies have been carried out to confirm the identity of these methylated bases in DNA as 7-methylguanine and 06- ... |
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| Microplanktonic ATP-Biomass and GTP-Productivity Associated with Upwelling off Pt. Sur, California. |
SEP 1980 |
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| Authors:
Sherman Hughes Bronsink; NAVAL POSTGRADUATE SCHOOL MONTEREY CA
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| Microplanktonic ATP-biomass and GTP-productivity were studied in upwelling features off Pt. Sur, California. Biomass, determined by adenosine triphosphate (ATP) and chlorophyll a, was found to have a definite preferential location in the strong gradients of temperature and nutrients on the equatorward edge of the feature. Productivity, as sampled using the new method of guanosine triphosphate (GTP) sampling was found to be high throughout the thermo-nutrient gradient associated with an upwelling ... |
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| HOST-PARASITE INTERACTIONS AND GENETICS OF ACTINOPHAGES. |
25 JUN 1969 |
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| Authors:
Sterling Gaylen Bradley; MINNESOTA UNIV MINNEAPOLIS DEPT OF MICROBIOLOGY
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| The life cycle of phages for streptomycetes and nocardiae were experimentally divided into distinct stages. These included: reversible attachment, irreversible attachment, injection, eclipse, synthesis of viral structural components, maturation, and release. We have confirmed that methylene blue photoinactivates bacterial viruses by photochemical destruction of guanine. In addition, it was shown that riboflavin photochemically destroys guanine. The mechanism of proflavine remains unresolved. In either the light or dark, proflavine binds to ... |
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| THE EXCRETION PROCESSES AND FUNCTION OF MALPIGHIAN TUBULES OF IXODID TICKS, |
1968 |
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| Authors:
Yu. S. Balashov; NAVAL MEDICAL RESEARCH UNIT NO 3 CAIRO (EGYPT) DEPT OF MEDICAL ZOOLOGY
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| Discharge products of ixodid ticks including typical excrement, which is guanine, also consist of hematin and undigested blood discharged into the rectal sac. Malpighian tubules do not take an active part in water and salt elimination. Their basic function is discharge of the final product of nitrogenous metabolism, guanine. Distinct division of Malpighian tubule activity cycles into periods of accumulation of excrement in them--'charging' and 'discharging'--is lacking in ixodid ticks. ... |
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| ON THE MELTING TRANSITION OF HIGH-MOLECULAR-WEIGHT DNA. |
MAY 1966 |
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| Authors:
Sigfrid Strassler; CALIFORNIA UNIV BERKELEY DEPT OF PHYSICS
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| One of the major difficulties in calculating transition curves for the melting of DNA is to take into account the fact that all of the base pairs do not have the same stability. Two kinds of base pairs of differing stability corresponding to adenine-thymine and guanine-cytosine are recognized by the model used in this paper. For a periodic arrangement of the two components an exact equation for the partition function ... |
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| MUTAGENICITY OF CYTOSINE FOR AN ADENINE AND ARGININE REQUIRING STRAIN OF CADIDA ALBICANS, |
1965 |
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| Authors:
A. Sarachek; WICHITA STATE UNIV KANS DEPT OF BIOLOGY
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| An adenine-arginine double auxotroph of Candida albicans exhibits increased back mutation to arginine independence when cultivated in the presence of growth inhibiting levels of cytosine. Of the natural nucleic acid bases, only adenine or guanine relieve growth inhibition and mutation; adenine is more effective than guanine in relieving inhibition but less effective than guanine in preventing mutation. Previous studies have shown that cytosine renders adenine auxotrophs of C. albicans purine ... |
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| KINETIC STUDIES ON THE THERMAL DENATURATION OF DEOXYRIBONUCLEIC ACID WITH A HIGH-FREQUENCY HEATING METHOD, |
24 JUL 1964 |
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| Authors:
Shiro Takashima; Eugene A. arnolds; ARMED FORCES INST OF PATHOLOGY WASHINGTON D C
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| The rate of heat denaturation of calf-thymus, salmonsperm and bacterial DNA's was studied with a highfrequency electric heating system. It was found that the rate of heat denaturation of DNA is rather slow, requiring more than 3 sec. The rate of denaturation is dependent on the guanine-cytosine content, and it is faster when the guanine-cytosine content is smaller. The rates are also faster below pH 5.0. Furthermore, the rate is ... |
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| PROMOTION OR RETARDATION OF THE GROWTH OF ADENINE AUXOTROPHS OF CANDIDA ALBICANS BY PURINES, PYRIMIDINES AND NUCLEOSIDES, |
27 APR 1964 |
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| Authors:
A. Sarachek; WICHITA STATE UNIV KANS
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| A study has been made of the growth responses to purine and pyrimidine metabolites shown by sixteen ultraviolet-induced adenine requiring mutants of Candida albicans blocked at early stages in purine biosynthesis. The salient findings establish that, in C. albicans, (1) the pathway for the conversion of adenine to guanine is not reversible, (2) exogenous nucleotides are not utilized, and the purine and pyrimidine components of exogenous nucleosides must be converted ... |
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| THE ENERGY BAND STRUCTURE OF POLYNUCLEOTIDES IN THE HUECKEL APPROXIMATION |
15 MAY 1962 |
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| Authors:
J. LADIK; K. APPEL; UPPSALA UNIV (SWEDEN)
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| Taking as model systems the polynucleotides poly A, poly T, poly G poly C and poly U in a stereo arrangement according to the WatsonCrick model of DNA, the energy bands of these macromolecules were calculated in the ueckel approximation. Simple polynomial expr ssions wer foun for the energy values as functions of cos k and with the aid of these the limits of all the occurring energy bands were ... |
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Reports by Keyword(s)
GUANINE
