| AMSARA: Accession Medical Standards Analysis & Research Activity Annual Report |
1998 |
107 pages |
| Authors:
K. L. Clark; M. R. Krauss; P. W. Kelley; J Onaitis; Y. Li; WALTER REED ARMY INST OF RESEARCH WASHINGTON DC DIV OF PREVENTIVE MEDICINE
|
 | The Accession Medical Standards Analysis and Research Activity (AMSARA) is a major new epidemilogic entity in its second year. Historically, military medical accession policy and waiver deliberations were based heavily on expert opinion. AMSARA produces analyses of epidemiologic data necessary for the joint personnel and medical general officers on the Department of Defense (DoD) Accessions Medical Standards Steering Committee to make evidence-based accession policy decisions. Studies of data quality, current ... |
|
| Addressing Emerging Infectious Disease Threats A Strategic Plan for the Department of Defense |
1998 |
53 pages |
| Authors:
WALTER REED ARMY INST OF RESEARCH WASHINGTON DC DIV OF PREVENTIVE MEDICINE
|
| Historians in the next millennium may find that the 20th century's greatest fallacy was the belief that infectious diseases were nearing elimination. The resultant complacency has actually increased the threat. Both naturally occurring and bioterrorist infectious disease agents hold an increasing potential to destabilize international security. Failure to recognize and accept this concept will lead to disaster. Globally, infectious diseases remain the leading cause of death. The ability of microbes ... |
|
| Pulse Check. Trends in Drug Abuse, January - June 1998 |
1998 |
64 pages |
| Authors:
Barry R. McCafffrey; OFFICE OF NATIONAL DRUG CONTROL POLICY WASHINGTON DC
|
| Since its inception in 1992, Pulse Check: Trends in Drug Abuse has been published either quarterly or semi-annually by the Office of National Drug Control Policy. Its purpose is to describe trends in drug abuse as they develop before population-based, long-term research is available to policy makers and researchers. Pulse Check uses reports from ethnographers and epidemiologists, law enforcement officials, and treatment providers, all working in the fields of drug ... |
|
| The Influence of Smoking on Disability Following Hospitalization for Musculoskeletal Disorders |
1998 |
241 pages |
| Authors:
Andrew E. Lincoln; JOHNS HOPKINS UNIV BALTIMORE MD SCHOOLOF HYGIENE AND PUBLIC HEALTH
|
| The purpose of this research was to investigate risk factors for the development of physical disability following the incidence of a musculoskeletal disorder. The natural history of various diagnostic categories was described from the point of initial hospitalization to the outcome of medical discharge from the service for disability. In addition, potential risk factors that may contribute to this outcome were studied. In particular, the ... |
|
| Surveillance after Initial Treatment for Breast Cancer: A Population- based Study of Variation In and Outcomes of Care |
NOV 1997 |
18 pages |
| Authors:
Ann B. Nattinger; MEDICAL COLL OF WISCONSIN MILWAUKEE
|
| A cohort was assembled of 3885 women from the Surveillance, Epidemiology, and End Results (SEER) Registry, who were aged 65 or older at the time of diagnosis of early stage breast cancer in 1991, who underwent initial surgical treatment, and for whom Medicare claims could be linked. During the two years following the initial treatment period, 62% underwent annual mammography, and 85% had at least one mammogram. When controlling for ... |
|
| Female Reproductive Effects of Exposure to Jet Fuel at U.S. Air Force Bases |
NOV 1997 |
66 pages |
| Authors:
Grace K. Lemasters; CINCINNATI UNIV OH
|
| One of the prevalent exposures at all Air Force (AF) bases is to jet fuel. Total consumption ranks in the billions of gallons. Jet fuel is composed of aliphatic/aromatic hydrocarbons and traces of metals that have potential adverse effects on health including menstrual disorders infertility, spontaneous abortions, and fetal effects. The mean age of active enlisted female Air Force personnel is 27.6 This study ad- dresses whether or not women ... |
|
| Chromium Environmental Risk Assessment |
NOV 1997 |
72 pages |
| Authors:
E. K. Vermulen; L. M. May; T. A. Hoffman-Till; J. K. Prince; P. A. Lurker; OPERATIONAL TECHNOLOGIES CORP DAYTON OH
|
| A review of chromium environmental criteria, supporting scientific studies and recent research activities was conducted to determine the implications of evolving observations on cancer risk to DoD environmental clean- up programs. Public concern over the occupational cancer risk of hexavalent chromium is influencing a new assessment of the risk data. Toxicology literature on the human health hazards, cancer and non-cancer, was reviewed. On-going epidemiology efforts were unavailable for a thorough ... |
|
| Tenth International Pathogenic Neisseria Conference |
NOV 97 |
644 pages |
| Authors:
Edmund C. Tramond; MARYLAND UNIV BALTIMORE
|
| The Tenth International Pathogenic Neisseria Conference was held in Baltimore, Maryland, September 8-13, 1996. This major international conference was attended by 400 scientists and public health officials from over 30 countries. The meeting featured both oral and poster presentations. Over 200 posters were presented. Poster breakout sessions were moderated by preselected participants. "Meet the Professor" talks focused on the clinical aspects of gonococcal and meningococcal infection. The goal was to ... |
|
| Regional Breast Cancer Screening Network |
OCT 1997 |
144 pages |
| Authors:
E. R. Greenberg; DARTMOUTH COLL HANOVER NH
|
| The long-term objective of this Project is to improve the health of New Hampshire women by improving breast cancer screening and detection. To accomplish this, the New Hampshire Mammography Network is implementing a comprehensive database tracking system, which allows us to follow the outcomes of women receiving mammography (either diagnostic or screening) and other breast procedures (biopsy or fine needle aspiration) over time. The first year ... |
|
| Breast Cancer Research Training Grant |
OCT 1997 |
61 pages |
| Authors:
Adrianne E. Rogers; BOSTON UNIV MA SCHOOL OF MEDICINE
|
| The purpose of the program is to train predoctoral students at Boston University Schools of Medicine and Public Health (BUSM, BUSPH) in research into the etiology, prevention, detection, diagnosis and therapy of breast cancer using the most advanced knowledge and techniques available. In addition to providing training in the student's chosen discipline, the program ensures her or his education in other relevant disciplines. Emphasis is placed ... |
|
| California Cancer Registry Enhancement for Breast Cancer Research |
OCT 1997 |
77 pages |
| Authors:
William Wright; CALIFORNIA PUBLIC HEALTH FOUNDATION BERKELEY
|
| The purpose of this project is to enhance the value of the California Cancer Registry as a research tool for clinicians and epidemiologists interested in conducting breast cancer research. The objectives of the project are to: (1) classify breast cancers according to the major staging schemes currently in us in the U.S.; (2) increase the amount of treatment data for breast cancer; and (3) link breast cancer case data with ... |
|
| Biological Specimen Bank to Enhance Population Based Studies of Inherited Breast Cancer Genes |
OCT 97 |
22 pages |
| Authors:
Frederick P. Li; DANA-FARBER CANCER INST BOSTON MA
|
| The objectives of this infrastructure enhancement project are to establish a population-based biological specimen and companion risk-factor data bank on 225 invasive breast cancer cases, aged 35 and under. These breast cancer cases have been enrolled through the tumor incidence registries in Connecticut, Massachusetts and 7 regions in California with a total population of 21 million (8% of US women). Demographic, epidemiologic and family history data have been collected on ... |
|
| Puberty Differentiation and Breast Cancer Risk |
OCT 1997 |
17 pages |
| Authors:
Lewis Chodosh; Stephen Master; PENNSYLVANIA UNIV PHILADELPHIA
|
| Breast cancer is the second most common cause of cancer mortality among women in the United States, and as such it is a disease with substantial clinical relevance. Several lines of evidence, including both epidemiological studies in humans and carcinogen studies in rodents, have suggested that puberty represents a period of enhanced susceptibility to carcinogenesis in the breast. We hypothesize that a change in the epithelial cell subtypes present during ... |
|
| Multigenerational Breast Cancer Risk Factors in African-American Women |
OCT 1997 |
27 pages |
| Authors:
Selina A. Smith; MIAMI UNIV FL SCHOOL OF MEDICINE
|
| An increased rate of breast cancer has been observed in African-American women under 50 years of age. Few epidemiologic studies of breast cancer focus explicitly on African-American women, and it is not established whether standard risk factors apply. This study seeks to determine relationships between risk factors and genetics in breast cancer etiology among pre-menopausal African-American women. |
|
| Early Stage Breast Cancer in Older Women: Predictors and Outcomes of Therapy |
OCT 1997 |
22 pages |
| Authors:
Ann B. Nattinger; MEDICAL COLL OF WISCONSIN MILWAUKEE
|
| The goal of this project is to develop from secondary data bases a population-based observational cohort to study the relationship of initial surgical treatment for breast cancer and specific outcomes. In the initial grant year, work has focused on the development of an algorithm to identify women with early stage breast cancer treated with mastectomy or breast-conserving treatment (BCT) using Medicare claims. Compared to Surveillance, Epidemiology and End Results (SEER) ... |
|
| Lifetime Alcohol Exposure and Breast Cancer Risk |
OCT 97 |
10 pages |
| Authors:
Jo Freudenheim; STATE UNIV OF NEW YORK AT BUFFALO AMHERST
|
| This case control study examines breast cancer risk in relation to lifetime alcohol consumption. Subjects are 335 white and 35 black pre-menopausal and 900 white and 80 black postmenopausal women, age 35 to 79, from Erie and Niagara counties in western New York State, with incident, pathologically confirmed breast cancer. Controls are randomly selected and are frequency matched to cases on age, race and county of residence. Subjects receive a ... |
|
| Study of the Met Tyrosine Kinase in the Pathogenesis of Breast Cancer |
OCT 1997 |
20 pages |
| Authors:
T. J. Liang; MASSACHUSETTS GENERAL HOSPITAL BOSTON
|
| Breast cancer is the most common malignancy affecting women in the Western World. Epidemiological studies have defined certain factors that may contribute to the risk of breast cancer, the most important one being a family history of the disease (1, 2). Approximately 5-10% of breast cancers are associated with inherited susceptibility with one or more autosomal dominant traits. Linkage at the estrogen receptor on chromosome 6 has also been reported ... |
|
| Genetic Abnormalities in Breast Cancer Tumors and Relationships to Environmental and Genetic Risk Factors Using Twins |
OCT 1997 |
17 pages |
| Authors:
Thomas M. Mack; UNIVERSITY OF SOUTHERN CALIFORNIA LOS ANGELES
|
| Archived tissue blocks are being sought on breast cancer concordant twin pairs (207 MZ and 131 DZ) and on discordant pairs (549 MZ), the presence of selected biomakers (p53, HER-2/neu, ER, and PR) in the tumor tissue is being determined, and the association of environmental and genetic factors with the development of these markers is being investigated. Blocks from 276 twins (200 from concordant pairs and 76 from discordant pairs) ... |
|
| Establishment of the Fox Chase Network Breast Cancer Risk Registry |
OCT 1997 |
68 pages |
| Authors:
Mary B. Daly; FOX CHASE CANCER CENTER PHILADELPHIA PA
|
| The wealth of research regarding the complex interaction of the genetic, biologic and environmental factors associated with breast carcinogenesis offers promise towards better understanding of breast cancer. The progress in molecular genetics provides us with opportunities to expand our knowledge about modifiable causes of breast cancer. The development of the Fox Chase Cancer Center Breast Cancer Risk Registry was proposed to facilitate research in ... |
|
| Does Subsequent Pregnancy Influence Breast Cancer Survival |
OCT 97 |
23 pages |
| Authors:
Ruby T. Senie; SLOAN-KETTERING INST FOR CANCER RESEARCH NEW YORK
|
| This retrospective study is designed to provide an assessment of the risk of recurrence and death associated with pregnancy following primary and adjuvant breast cancer treatment. This major concern of young breast cancer patients who may have delayed childbearing. A collaborative record-linkage study is underway using the unique computerized records maintained by the Kaiser Permanente of Northern California. Through linkage of the cancer registry and hospitalization records, young breast cancer ... |
|
| Epidemiologic Investigation of a Cluster of Cystosarcoma Phyllodes Tumors of the Female Breast |
SEP 1997 |
12 pages |
| Authors:
Stanley H. Weiss; UNIVERSITY OF MEDICINE AND DENTISTRY OFNEW JERSEY NEWARK
|
| Cystosarcoma phyllodes is an uncommon breast neoplasm. It is a fibroepithelial tumor composed or an epithelial and a cellular stromal component. A significant number of cases of cystosarcoma phyllodes tumors were diagnosed over the last several years at a single hospital in New Jersey. This study is systematically assessing the epidemiology of this tumor. Initial results confirm an apparent excess of cases compared to the number expected, with a total ... |
|
| Breast Cancer and Risk Factors Among African-American Women Aged 20-54: A Case-Control Study According to Estrogen Receptor |
SEP 97 |
89 pages |
| Authors:
Kangmin Zhu; MEHARRY MEDICAL COLL NASHVILLE TN
|
| This is an exploratory case-control study that aims to examine whether risk factor profiles differ according to estrogen receptor (ER) status among African-American women. Since the initiation of the study in September 1997, tremendous efforts have been made to formulate the study procedures, contact doctors, identify and recruit study subjects, and make various preparations. |
|
| Dietary Intake, Alcohol Consumption, and Menopausal Status: A Comparison of Hispanic and Non-Hispanic White Women |
SEP 1997 |
11 pages |
| Authors:
Kathy Baumgartner; TEXAS UNIV HEALTH SCIENCE CENTER AT HOUSTON
|
| The first year of work towards the completion of a doctoral degree, focused on breast cancer epidemiology, at the University of Texas School of Public Health (UTSPH), Houston, Texas has been completed. Data are a subset of that collected for the study, 'Breast Cancer Epidemiology in NM Hispanic Women'. The Principal Investigator of this training grant served as Project Director of this study conducted by the Epidemiology and Cancer Control ... |
|
| Predoctoral Training in Breast Cancer Biology and Therapy |
SEP 1997 |
61 pages |
| Authors:
John S. Lazo; PITTSBURGH UNIV PA
|
| Substantial improvements in the prevention, detection and treatment of breast cancer require the addition of new laboratory trained investigators. The objective of this predoctoral training program is to attract new investigators into the field of breast cancer research and to provide them with an interdisciplinary predoctoral training experience focused on this malignant disorder. The Program comprises a graduate faculty of 33, who are members of 12 departments at the University ... |
|
| Mutagenic Potential of Alternating Current Electric Fields |
SEP 97 |
28 pages |
| Authors:
John Obringer; Brandon Horne; Brian Kelchner; AIR FORCE ACADEMY COLORADO SPRINGS CO DEPT OF BIOLOGY
|
| Electromagnetic Fields (EMF) such as those produced by power lines have become a growing source of concern to the general public. Many epidemiological studies have linked EMF to carcinogenesis implying an underlying genetic phenomenon mediated by EMF. EMF can be subdivided into either electric fields (E-field) or magnetic fields (B-field). Our research used a reverse mutagenesis bacteriophage T4D model to quantitatively study the effects of E- fields on a molecular ... |
|
| Mutagenic Potential of Direct Current Magnetic Fields |
SEP 97 |
28 pages |
| Authors:
John W. Obringer; Tara E. Nolan; Brandon Horne; Brian Kelchner; AIR FORCE ACADEMY COLORADO SPRINGS CO DEPT OF BIOLOGY
|
| Electromagnetic Fields (EMF) such as those produced by power lines have become a growing source of concern to the general public. Many epidemiological studies have linked EMF to carcinogenesis implying an underlying genetic phenomenon mediated by EMF. EMF can be subdivided into either electric fields (E-field) or magnetic fields (B-field). Our research used a reverse mutagenesis bacteriophage T4D model to quantitatively study the effects of direct current magnetic fields (DC/B) ... |
|
| Assessment of the Potential Drug Etiology of Breast Cancer: Analyses of Data from a Case-Control Drug Surveillance Study |
SEP 97 |
15 pages |
| Authors:
Lynn Rosenberg; BOSTON UNIV MA
|
| The purpose of the present study is to assess the potential drug etiology of breast cancer through analyses of data from our hospital-based Case- Control Surveillance Study. We carried out computer 'screens' of the data to detect unsuspected associations: the use of each drug or drug class among women with breast cancer was compared to that among women admitted for other conditions. Odds ratios were significantly elevated or reduced for ... |
|
| Breast Cancer in Ataxia Telangiectasia Carriers |
SEP 1997 |
13 pages |
| Authors:
Michael M. Weil; TEXAS UNIV AT HOUSTON
|
| Individuals that carry a single mutated copy of the ATM gene appear clinically normal but may be at increased risk for breast cancer and for normal tissue damage from radiotherapy. We have developed a direct sequencing assay that can identify mutations and polymorphisms in the translated region of the ATM message. This assay is being used in a pilot study of the incidence of ATM mutations and polymorphisms in cancer ... |
|
| Biology of Breast Cancer: A Predoctoral Training Program |
SEP 1997 |
225 pages |
| Authors:
Nita J. Maihle; MAYO CLINIC ROCHESTER MN
|
| The Biology of Breast Cancer Predoctoral Training Program is a multidisciplinary predoctoral training program in tumor biology. The focus of this training program is to provide an educational environment that stimulates excellence in scientific thought and training while simultaneously providing exposure to all of the major fields of study relevant to breast cancer. Our goal is to provide students in the the training program with a solid and uniquely multidisciplinary ... |
|
| Utilization of An NCI Infrastructure to Evaluate Breast Cancer Patient Outcomes of Importance in Determining Priorities for New Health Care Reform |
SEP 1997 |
15 pages |
| Authors:
Garrett A. SMith; I. C. Henderson; CALIFORNIA UNIV SAN FRANCISCO
|
| This project continues to develop and refine a novel clinical curriculum that utilizes resources from diverse disciplines. I have combined sub-specialty training in oncology with formal courses in biostatistics, epidemiology, and health policy research, in order to develop expertise in clinical trials methodology and health care reform. The Clinical Research Scholars Program served as a foundation in outcomes research during the first year of the project. The second year of ... |
|
| Mutagenic Effect on Alternating Current Magnetic Fields |
AUG 1997 |
28 pages |
| Authors:
John W. Obringer; Brian Kelchner; Brandon Horne; AIR FORCE ACADEMY COLORADO SPRINGS CO DEPT OF BIOLOGY
|
| Electromagnetic Fields (EMF) such as those produced by power lines have become a growing source of concern to the general public. Many epidemiological studies have linked EMF to carcinogenesis implying an underlying genetic phenomenon mediated by EMF. EMF can be subdivided into either electric fields (E-field) or magnetic fields (B-fields). Our research used a reverse mutagenesis bacteriophage T4D model to quantitatively study the effects of E- fields on a molecular ... |
|
| The Role of the EGF Receptor First Intron in Its Regulation in Breast Canceer |
AUG 1997 |
58 pages |
| Authors:
Susan A. Chrysogelos; Melissa A. Wilson; GEORGETOWN UNIV WASHINGTON DC
|
| Hormone independent human breast cancer is characterized by estrogen receptor (ER) loss and the acquisition of high epidermal growth factor receptor (EGFR)levels. Despite the tendency for an inverse correlation between EGFR and ER, EGFR is a strong prognostic indicator for poor survival rate independent of ER status suggesting that EGFR overexpression is an important step in the progression to estrogen independence. Our studies have shown that several DNase I hypersensitive ... |
|
| Overhydration with Secondary Hyponatremia, Fort Benning, Georgia |
AUG 1997 |
87 pages |
| Authors:
Stephen Craig; Joe Knapik; John Brundage; Howard Cushner; Michae Sawka; ARMY CENTER FOR HEALTH PROMOTION AND PREVENTIVE MEDICINE (PROVISIONAL) ABERDEEN PROVING GROUND MD
|
| Martin Army Community Hospital (MACH), Ft. Benning, Georgia requested an epidemiological consultation (EPICON) in July 1997 to investigate 5 cases (1 fatal) of hyponatremia in basic trainees. The EPICON team was tasked to examine the nature, magnitude, causes, and risk factors related to this problem, and to provide recommendations to prevent further cases. Ft. Benning hospital databases and medical surveillance sources were searched to define problem. Hospital databases were searched ... |
|
| Delays and Refusals in Treatment for Breast Cancer Among Native American and Hispanic Women with Breast Cancer |
AUG 97 |
60 pages |
| Authors:
Elba L. Saavedra; Elias Duryea; NEW MEXICO UNIV ALBUQUERQUE
|
| The purpose of this study is to identify and describe the factors associated with delays in breast cancer treatment as mediated by psycho-social, cultural, and demographic variables among Hispanic, Native American and non- Hispanic white women. The scope of this study will enroll a total of 70 participants, 35 patients and 35 family members or other care givers identified by the patient. This ethnographic study will gather qualitative data through ... |
|
| Mutagenic Effect on Alternating Current Magnetic Fields |
AUG 97 |
28 pages |
| Authors:
John W. Obringer; Brandon Horne; Brian Kelchner; AIR FORCE ACADEMY COLORADO SPRINGS CO DEPT OF BIOLOGY
|
| Electromagnetic Fields (EMF) such as those produced by power lines have become a growing source of concern to the general public. Many epidemiological studies have linked EMF to carcinogenesis implying an underlying genetic phenomenon mediated by EMF. EMF can be subdivided into either electric fields (E-field) or magnetic fields (B-fields). Our research used a reverse mutagenesis bacteriophage T4D model to quantitatively study the effects of E- fields on a molecular ... |
|
| Mutagenic Potential of Direct Current Electric Fields |
AUG 97 |
29 pages |
| Authors:
John Obringer; Tara Nolan; Brian Kelchner; AIR FORCE ACADEMY COLORADO SPRINGS CO DEPT OF BIOLOGY
|
| Electromagnetic Fields (EMF) such as those produced by power lines have become a growing source of concern to the general public. Many epidemiological studies have linked EMF to carcinogenesis implying an underlying genetic phenomenon mediated by EMF. EMF can be subdivided into either electric fields (E-field) or magnetic fields (B-field). Our research used a reverse mutagenesis bacteriophage T4D model to quantitatively study the effects of direct current E-fields (DC/E) on ... |
|
| Training Program in Biostatistics for Breast Cancer Research |
JUL 1997 |
13 pages |
| Authors:
Roderick J. Little; MICHIGAN UNIV ANN ARBOR
|
| The purpose of this training program in biostatistics for breast cancer research is to provide biostatisticians with the requisite scientific knowledge to understand current issues in breast cancer research, and training in statistical and epidemiological techniques and research methodology related to breast cancer. The training leads to the doctorate of philosophy in biostatistics. The methods of training include formal course work in biostatistics, epidemiology and biology related to breast cancer, ... |
|
| Naval Health Research Center Update, Issue No. 6 |
JUL 1997 |
|
| Authors:
NAVAL HEALTH RESEARCH CENTER SAN DIEGO CA
|
 | Newly described or more virulent forms of infectious diseases are emerging throughout the world and causing epidemics at an alarming rate. Outbreaks once isolated to one city or country can spread exponentially through the convenience of modem air travel. Anew hepatitis virus in Africa or a new strain of cholera in Latin America has the potential to infect a myriad of other countries at any given time, including the United ... |
|
| Vitamin D and Breast Cancer |
JUL 97 |
27 pages |
| Authors:
Esther Janowsky; NORTH CAROLINA UNIV AT CHAPEL HILL
|
| Vitamin D metabolites may play a role in carcinogenesis. We analyzed 497 (case=152, control 1=179, control 2=166) archived samples of blood for two vitamin D metabolites: 25-hydroxyvitamin D (25-D) and 1,25-dihydroxyvitamin D (1,25-D). The samples were from black and white women participants in a previous case control study of breast cancer. Our data indicate that white women at the time of first diagnosis of breast cancer have significantly lower mean ... |
|
| Post-Doctoral Training: Case-Control Analysis of Breast Cancer |
JUL 97 |
14 pages |
| Authors:
Linda S. Cook; FRED HUTCHINSON CANCER RESEARCH CENTERSEATTLE WA
|
| This proposal provides funding for two years of postdoctoral training to support Dr. Cook's work on analyses involving the epidemiology of breast cancer in women. These analyses are being conducted using data from three population-based case control studies that collected detailed information on many factors known, or suspected to be, related to the risk of breast cancer. These analyses evaluate hypotheses of scientific and public health interest that were not ... |
|
| The Relationship Between Reliability and Validity in a Bayesian World |
JUL 97 |
18 pages |
| Authors:
Paul D. Retzlaff; William G. Jackson; ARMSTRONG LAB BROOKS AFB TX CLINICAL SCIENCES DIV
|
| While the relationship between internal consistency and validity in traditional tests is well established, little is available for tests that predict dichotomous diagnostic outcomes. An understanding of such a relationship is important in cases such as the prediction of clinician diagnoses by psychological tests. Tests such as the MCMI are validated against such clinical diagnoses. The limiting effects on positive predictive powers given levels of Kappa are developed. The current ... |
|
| Investigation of the Biological Characteristics of Amantadine-Resistant Influenza A Virus |
18 JUN 97 |
58 pages |
| Authors:
Carol C. Walters; AIR FORCE INST OF TECH WRIGHT-PATTERSON AFB OH
|
| Since the first report of amantadine-resistant strains of influenza in 1981 there has been much speculation about the epidemiological impact of these strains should the use of amantadine and rimantadine become widespread during an influenza pandemic. To date, there have been only two reports of confirmed resistant strains that were isolated from patients with no drug treatment. All other resistant strains have been collected only after therapy with either rimantadine ... |
|
| Rapid Malaria Test for Diagnosis and Treatment. Phase I |
JUN 1997 |
10 pages |
| Authors:
Michael T. Makler; FLOW INC PORTLAND OR
|
| Malaria infects over 200 million people and is responsible for 2 million deaths annually. Flow Inc. has developed diagnostic and culture and sensitivity procedures based upon the fact that the parasite contains an enzyme lactate dehydrogenase (pLDH) (US patent 5124141) Flow Inc. recently increased the sensitivity to 50-100 parasites/ul with monoclonal antibodies. These newly formatted wet (immunocapture), and dry (immuno-chromatographic) assays, can differentiate Plasmodium falciparum from other Plasmodium sp. that ... |
|
| Magnetic Resonance Spectroscopy: An Objective Modality to Identify the Pathology of Breast Neoplasms |
MAY 97 |
48 pages |
| Authors:
Carolyn Mountford; SYDNEY UNIV (AUSTRALIA)
|
| The purpose of this research is: (1) To assess the sensitivity and specificity of H MRS (ex vivo) in the detection of neoplasia in breast, based on altered cellular chemistry. (2) Correlate alterations to MRS detectable cellular chemistry associated with breast tumor development and progression with established clinicopathological criteria. (3) Ascertain MRS markers which correlate with known clinical, epidemiological and genetic risk factors to be used to identify women at-risk ... |
|
| NHRC Update. Issue Number 1-5 |
APR 97 |
21 pages |
| Authors:
NAVAL HEALTH RESEARCH CENTER SAN DIEGO CA
|
| CAPT Stephanie Brodine and her colleagues, including Dr. Frank Garland and Stan Ito from NHRC, and researchers from Walter Reed Army Institute of Research Retrovirology Lab, identified the first cases of U.S. natives infected with the HIV-l strains causing the African and Asian epidemics. This study, published in the November 5, 1995 issue of Lancet, used new state-of-the- art laboratory techniques to identify the specific strains or subtypes of HIV. ... |
|
| Vitamin D and Breast Cancer |
APR 97 |
14 pages |
| Authors:
Esther Janowsky; NORTH CAROLINA UNIV AT CHAPEL HILL
|
| The purpose of our current work is to determine whether there are differences in blood levels of 1,25-dihydroxy- vitamin D between women with breast cancer and two control groups of women without breast cancer. We are using archived samples of blood obtained from women in a just completed case- control study of genetic risk factors for breast cancer. In addition, we are working to modify the immunohistochemical technique for detection ... |
|
| Respiratory Pathogens of Military Importance: A Review |
MAR 97 |
21 pages |
| Authors:
C. C. Gray; NAVAL HEALTH RESEARCH CENTER SAN DIEGO CA
|
| Respiratory pathogens have been, and continue to be, a major cause of morbidity among military populations. This review describes the epidemiology, clinical manifestations and control strategies for the most commonly encountered bacterial and viral pathogens. Streptococcas pyogenes, Streptococcus pneumoniae, Mycoplasma pnelimonzae, Chiamydia pneumoniae, inilueriza, and adenoviruses are examined. As these pathogens change and new threats emerge, military public health policy must adapt to meet these challenges. |
|
| Morbidity and Mortality Weekly Report. Volume 47. Number RR-1. 1998 Guidelines for Treatment of Sexually Transmitted Diseases |
23 JAN 1997 |
128 pages |
| Authors:
CENTERS FOR DISEASE CONTROL ATLANTA GA
|
| The MMWR series of publications is published by the Epidemiology Program Office, Centers for Disease Control and Prevention (CDC), U.S. Department of Health and Human Services, Atlanta, GA 30333. These guidelines for the treatment of patients who have sexually transmitted diseases (STDs) were developed by CDC staff members after consultation with a group of invited experts who met in Atlanta on February 10-12, 1997. The information in this report updates ... |
|
| Presidential Advisory Committee on Gulf War Veterans' Illnesses |
07 JAN 97 |
193 pages |
| Authors:
PRESIDENTIAL ADVISORY COMMITTEE ON GULF WAR VETERANS' ILLNESSES WASHINGTON DC
|
| Approximately 697,000 men and women served in Operations Desert Shield/Desert Storm (table 1-1) from August 1990 to June 1991. Americans who fought the Gulf War differed from any force in U.S. history: There was more ethnic diversity, and there were more women, more parents, and more individuals- activated members of the Reserves and National Guard-uprooted from civilian jobs. During the war, U.S. troops suffered 148 combat deaths and 145 deaths ... |
|
| Environmental Exposures, Genetic Polymorphisms and p53 Mutational Spectra in a Case-Control Study of Breast Cancer |
JAN 1997 |
57 pages |
| Authors:
Peter G. Shields; NATIONAL INSTITUTES OF HEALTH BETHESDA MD
|
| The first goal of this project is to determine the frequency of genetic polymorphisms for carcinogen metabolism and the p53 mutational spectra in a previously conducted breast cancer case-control study. We have determined that the NAT2 slow acetylator genotype and cigarette smoking is a risk factor for postmenopausal Caucasion women. Analyses for NAT1 is now in progress. We also have found that the alcohol dehydrogenase gene increases alcohol-related breast cancer ... |
|
Reports by Keyword(s)
EPIDEMIOLOGY
