| HTS Josephson Technology on Silicon With Application to High Speed Microelectronics |
16 MAY 2001 |
50 pages |
| Authors:
David G. Hamblen; Joseph Cosgrove; ADVANCED FUEL RESEARCH INC EAST HARTFORD CT
|
 | Superconducting electronics have long been regarded as having the potential for superior switching speeds and reduced power consumption compared to semiconducting devices. High temperature superconducting materials, such as YBa2Cu3O7, present many new opportunities. Because many targeted applications of superconducting electronics rely on the high switching speeds attainable by Josephson junctions, however, rf properties have played a significant role in the search for practical substrates. The overall goal of this Phase ... |
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| Upper Yellowstone River Hydrogeomorphic Functional Assessment for Temporal and Synoptic Cumulative Impact Analyses |
MAY 2001 |
24 pages |
| Authors:
F. R. Hauer; Bradley J. Cook; Marcus Miller; Chris Noble; Tom Gonser; ENGINEER RESEARCH AND DEVELOPMENT CENTER VICKSBURG MS
|
| Until recently, methods of evaluating wetland loss or degradation were either so generalized that detection of change was not quantifiable or required exhaustive research beyond the human or financial resource scope of a regulatory program. The hydrogeomorphic (HGM) approach to the functional assessment of wetlands was specifically developed, principally by the U.S. Army Corps of Engineers and other Federal and state agencies throughout the United States, as a comprehensive framework ... |
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| Technologies for Urban Stream Restoration and Watershed Management |
MAY 2001 |
11 pages |
| Authors:
J. C. Fischenich; ENGINEER RESEARCH AND DEVELOPMENT CENTER VICKSBURG MS
|
| This bulletin is published in accordance with AR 25-30 as an information exchange bulletin of the Corps of Engineers. Its purpose is to disseminate research results on emerging problems addressed by the Corps' Ecosystem Management and Restoration Research Program. The topics discussed are: Technologies for urban stream restoration and watershed management, Impacts of Urbanization, Economics of Stream Degradation, and The Urban Restoration Challenge. |
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| The Influence of Projectile Mass upon Precision |
26 APR 2001 |
8 pages |
| Authors:
E. Schmidt; H. Edge; ARMY RESEARCH LAB ABERDEEN PROVING GROUND MD
|
| Precision, or round-to-round dispersion is an important parameter contributing to the accuracy of tank fire. It is typically a lot acceptance specification for ammunition, both war and target practice rounds. A kinetic energy war round is fabricated from a dense metal such as tungsten alloy while the practice round is made from steel. In an attempt to improve training round performance and lower cost, a series of designs using aluminum ... |
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| Use of the SIMBAD Gun Dynamics Code for Modelling the In-Bore Dynamics of EM Launchers |
26 APR 2001 |
15 pages |
| Authors:
D. W. Lodge; A. M. Dilkes437; DEFENCE EVALUATION AND RESEARCH AGENCY SURREY (UNITED KINGDOM)
|
| Generic SIMBAD models of various Electro-Magnetic (EM) launchers have been used in the UK for studying model the in-bore phase and launch accuracy issues of such systems. Although many of features of the EM environment are not modelled with any degree of complexity, SIMBAD still provides a useful tool for investigating some of the dominant material and geometric influences on the in-bore dynamics and launch accuracy. Modifications to the SIMBAD ... |
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| Investigation of Tungsten, Copper, and Silver Alloys with Indium at the Rail-Armature Interface on a Railgun Test Bench |
26 APR 2001 |
14 pages |
| Authors:
D. Gillich; W. Maier; MILITARY ACADEMY WEST POINT NY DEPT OFPHYSICS
|
| With the advent of electrically propelled ships, the Navy is now considering the use of electric power to launch projectiles in support of maritime land attack. Bore wear is one of the most significant challenges for a naval railgun program. The interface between the armature and rails is the most stressed point of a railgun because it transitions to liquid under high current densities. This liquid interface causes rail and ... |
|
| Phytotechnology Technical and Regulatory Guidance Document |
01-Apr-2001 |
124 pages |
| Authors:
INTERSTATE TECHNOLOGY AND REGULATORY COUNCIL WETLANDS TEAM WASHINGTON DC
|
| Terminology in this field of using plants to remediate, treat, stabilize, and control contaminated media is rather new. Throughout the development process of this document, we referred to the science as phytoremediation. Recently realizing that we are actually discussing a variety of technologies and techniques in various applications to manage a contaminant, a contaminated plume, or the media containing contaminants, we now refer to phytotechnologies as the overarching terminology, while ... |
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| Historical Analysis of Land Cover/Condition Trends at Fort Bliss, Texas, Using Remotely Sensed Imagery |
APR 2001 |
68 pages |
| Authors:
Scott Tweddale; ENGINEER RESEARCH AND DEVELOPMENT CENTER CHAMPAIGN IL CONSTRUCTION ENGINEERING RESEARCH LAB
|
| Fort Bliss, Texas, is a Training and Doctrine Command installation located in the semi-arid Northern Chihuahuan Desert of Western Texas and South Central New Mexico. Military training (both tracked and wheeled vehicles), grazing, and recreational activities act as stressors on the landscape. The natural resource managers need information on land condition to make informed land management decisions and to support conservation and compliance efforts. They need a cost-effective method of ... |
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| Strategy for the Successful Implementation of U.S. Southern Command's Environmental Security Supplement to USCINCSO Theater Engagement Plan |
APR 2001 |
270 pages |
| Authors:
Kevin E. Rumsey; MIAMI UNIV CORAL GABLES FL CENTER FOR ADVANCED INTERNATIONAL STUDIES
|
| Population growth, globalization and conflict contribute to environmental degradation and resource scarcity. In turn, scarcity and degradation may lead to conflict, negatively affect quality of life and economic conditions, degrade environmental security and destabilize state security. To address this problem, the United States has economic, political, and military instruments of power (IOP) at their disposal to combat the environmental damage or its impact, thereby improving environmental security. The difficulty is ... |
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| New Classes of Conditional Toxins as Therapeutic Agents Against Breast Cancer |
APR 2001 |
228 pages |
| Authors:
Alexander Varshavsky; CALIFORNIA INST OF TECH PASADENA
|
| During the three-year duration of this grant ((DAMD17-98-1-8042, the Idea Grant), we focused on the following projects: (1) Development of signal- regulated, cleavage-mediated toxins. During this time, we completed the work on the CUP9-mediated, HIV protease-dependent conditional toxins. A paper describing these results has been finished (its completion was delayed by difficulties in some of the necessary control experiments). This paper will be submitted for publication in the Fall of ... |
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| Non-Polluting Composites Repair and Remanufacturing for Military Applications: Induction-Based Processing |
APR 2001 |
61 pages |
| Authors:
Bruce K. Fink; Nicholas B. Shevchenko; James M. Sands; Shridhar Yarlagadda; John W. Gillespie Jr; ARMY RESEARCH LAB ABERDEEN PROVING GROUND MD
|
| The development of induction-based processing of carbon-fiber (CF) thermoplastic-matrix composites and accelerated cure of thermosetting adhesives has the potential to provide nonautoclave processing technology for manufacturing and repair of polymer-matrix composites (PMCs). In this report, the results of recent tests demonstrating bonding of composites using commercial off-the-shelf thermal-cure adhesives that are heat cured via an induction field using an inductive susceptor are discussed. This method of cure utilizes heat generation ... |
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| Effect of Scattering Noise on the Data Fidelity of Holograms Recorded in Photorefractive Crystals |
APR 2001 |
6 pages |
| Authors:
Mingyan Qin; Shiquan Tao; Guoqing Liu; Xiaohong Ding; Dayong Wang; POLYTECHNIC UNIV BEIJING (CHINA) COLLEGE OF APPLIED SCIENCES
|
| In this paper a method is proposed to investigate how the scattering noise of photorefractive crystals influences the quality of an input data page in holographic storage. By illuminating the crystal under investigation with an intense coherent light beam, and measuring the signal-to-noise ratio (SNR) of an image formed through the crystal before and after the exposure, the loss of SNR provides a good assessment for the suitability of the ... |
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| Development of Triplex-Forming Oligonucleotides to Inhibit Expression of the c-myc Oncogene in Breast Cancer Cells |
APR 2001 |
7 pages |
| Authors:
Eileen M. McGuffie; Carlo V. Catapano; MEDICAL UNIV OF SOUTH CAROLINA CHARLESTON
|
| Triple helix-forming oligonucleotides (TFOs) bind with high affinity and specificity to homopurine/homopyrimidine sequences in double-stranded DNA. Oligonucleotide- directed triplex formation in gene promoter regions has been shown to inhibit transcription of targeted genes. C-myc is a growth%-promoting oncogene that is deregulated and overexpressed in breast and other cancers. Our research is designed to assess TFO-mediated reduction of c-myc expression as a means of decreasing breast tumor growth. The purpose of ... |
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| Role of Seprase in Breast Cancer |
APR 2001 |
41 pages |
| Authors:
Thomas J. Kelly Jr.; ARKANSAS UNIV FOR MEDICAL SCIENCES LITTLE ROCK
|
| This is the final report documenting the achievements of DAMDI7-96-I-6097 "Role of seprase in breast cancer invasion". The goals were to produce full length seprase cDNAs and use these to produce cells that overexpress seprase. These seprase expressing cells were to be evaluated for invasive behavior relative to those that do not express seprase. The major goals of the project have been accomplished with the exception of engineering seprase- negative ... |
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| The Target Sites on EGF Receptor for Cb1, It's Negative Regulator |
APR 2001 |
41 pages |
| Authors:
Amiya Ghosh; Hamid Band; BRIGHAM AND WOMEN'S HOSPITAL BOSTON MA
|
| Activation of tyrosine kinases plays a key role in breast cancer cell proliferation. ErbB receptors and Src-family tyrosine kinases are specifically implicated in breast cancer. Earlier, we showed that Cb1, a negative regulator of EGF receptor (ErbE1), enhances sorting of the activated EGFR into lysosomes as opposed to its recycling to the cell surface. These findings, together with studies implicating Src-family kinases as positive modulators of EGFR signaling, led us ... |
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| Space-Time Adaptive FIR Filtering with Staggered PRI |
14 MAR 2001 |
|
| Authors:
R. Klemm; RESEARCH ESTABLISHMENT FOR APPLIED SCIENCES WACHTBERG- WERTHHOVEN (GERMANY)
|
 | Space-time least squares far infrared radiation (FIR) filters have shown excellent clutter rejection performance at extremely low computational loads, allowing ground moving target indication (GMTI) to be carried out in real-time. Staggering the pulse repetition interval (PRI) is an appropriate way of avoiding Doppler ambiguities and blind velocities. Fully adaptive space-time processors can cope well with staggered echo data. FIR filtering techniques are based on constant PRI and, therefore, will ... |
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| Space-Time Adaptive FIR Filtering With Staggered PRI |
14 MAR 2001 |
15 pages |
| Authors:
Richard Klemm; FGAN-FHR RESEARCH INST FOR HIGH FREQUENCY PHYSICS AND RADAR TECHNIQUES WACHTBERG (GERMANY)
|
|
| Statement of Robert J. Lieberman Deputy Inspector General Department of Defense Before the Subcommittee on National Security, Veterans Affairs and International Relations, House Committee on Government Reform on Defense Security Service: Mission Degradati |
02 MAR 2001 |
15 pages |
| Authors:
INSPECTOR GENERAL DEPT OF DEFENSE ARLINGTON VA
|
| I am pleased to be here today to discuss the continuing and serious challenges facing the Department of Defense Personnel Security Program. As you know from your hearings in February and September 2000, the Department's ability to comply with Federal guidelines on security clearances and to carry out the several hundred thousand investigations needed annually for initial clearances or updates virtually collapsed during the late 1990's. The causes included: an ... |
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| Modeling Chlorinated Ethene Removal in the Methanogenic Zone of Constructed Wetlands: A System Dynamics Approach |
MAR 2001 |
185 pages |
| Authors:
Randall L. Roberts; AIR FORCE INST OF TECH WRIGHT-PATTERSONAFB OH
|
| The purpose of this study is to gain understanding of the dynamics of the processes that degrade Perchloroethene (PCE) to ethene, within the confines of the methanogenic zone of a constructed wetland. A system dynamics modeling approach is used. This model is focused on determining conditions that will enhance contaminant degradation. The chemical and biological processes within the methanogenic zone of a wetland system are extremely complex and dynamic processes. ... |
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| Analytical System for Identification of By-Products Produced from the Incomplete Degradation of Relevant Department of Army Contaminants During Treatment Activities-II |
MAR 2001 |
22 pages |
| Authors:
Mark E. Zappl; MISSISSIPPI STATE UNIV MISSISSIPPI STATE SCHOOL OF CHEMICAL ENGINEERING (DAVE C SWALM)
|
| This report describes the items purchased under the second project, summarizes their use to date, and details how these equipment have increased the research capability of MSU toward assisting DoD with development of cleanup technology. |
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| An Anion Characterization of a Constructed Wetland Used for Chlorinated Ethene Remediation |
MAR 2001 |
264 pages |
| Authors:
Bradley M. Bugg; AIR FORCE INST OF TECH WRIGHT-PATTERSONAFB OH
|
| Chlorinated ethene's physical properties as well as its ubiquitous state at DOD installations makes it a priority for innovative remediation efforts. Current techniques are expensive and time consuming to maintain. Constructed wetlands suggest an inexpensive and operational alternative to conventional technologies. Sub-surface flow wetlands provide the anaerobic zones necessary to reduce the recalcitrant chlorinated solvents prior to anaerobic or aerobic mineralization of its daughter products. A vertical flow cell to ... |
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| Communications Issues in Shipboard Telemedicine |
MAR 2001 |
76 pages |
| Authors:
A. D. Ramirez; S. D. Russell; C. B. Phillips; M. W. Roberts; L. C. Russell; SPACE AND NAVAL WARFARE SYSTEMS CENTER SAN DIEGO CA
|
| This study defines the specific communications capabilities of U.S. Navy ships and identifies operational problems and technical barriers prohibiting telemedicine on a wide scale. This information is needed so the transmission of medical data can be managed in conformance with shipboard capabilities and contingencies can be developed for the potential degradation of those capabilities. While communications requirements for telemedicine in the civilian sector continue to be defined and implemented on ... |
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| Androgen Regulation of p27 in the Normal and Neoplastic Prostate |
MAR 2001 |
56 pages |
| Authors:
Massimo Loda; DANA-FARBER CANCER INST BOSTON MA
|
| The cyclin dependent kinase inhibitor (CKI) p27 is a negative regulator of the cell cycle and a potential tumor suppressor gene. p27 deficient mice develop pituitary tumors and display increased body size suggesting a growth-inhibitory function in vivo. In addition, our preliminary data at the time the grant was submitted suggested that its expression in the prostate was regulated by androgens. The original aims of this proposal included 1) to ... |
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| Radiation Test on a Small DC-DC Converter |
20 FEB 2001 |
23 pages |
| Authors:
C. H. Truong; K. Siri; J. C. Ross; S. Brown; A. Prater; AEROSPACE CORP EL SEGUNDO CA LAB OPERATIONS
|
| This report presents the approach to and results of the total dose and dose rate testing on a typical low-power dc-dc converter used in cellular phones, beepers, and other portable devices. The dc-dc power converter under test will be employed to convert the unregulated battery voltage to a regulated 5-V bus in the power system of the PowerSphere power management architecture for micro- and nano-satellites and the Pico-2 picosatellites currently ... |
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| Gun Tube Coatings in Distress |
FEB 2001 |
45 pages |
| Authors:
Paul J. Conroy; Paul Weinacht; Michael J. Nusca; ARMY RESEARCH LAB ABERDEEN PROVING GROUND MD
|
| The effects of thermal, chemical, and mechanical stress components of erosion on the degradation and failure of current and potential future gun tube coating materials are investigated. Potential failure mechanisms at the interface are shown and discussed. The interfacial coating/base material stress calculation methodology, including coating crack formation and coating adhesion criteria, is presented. Possible erosion mitigation concepts are also presented to counteract the formation of cracks in the coating. ... |
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| Inelastic Deformation and Strength Degradation in Shocked Geologic Solids |
22 JAN 2001 |
4 pages |
| Authors:
Yogendra M. Gupta; Jow-Lian Ding; WASHINGTON STATE UNIV PULLMAN
|
| Two research tasks were initiated in this project. In the first, preliminary calculations were carried out to examine the response of miniature ruby gauges in metallic targets subject to axisymmetric loading. Although the initial results were encouraging, the calculational effort was discontinued because funding changes by AFOSR did not permit experimental work in this project. In the second task, the development of a damage model was undertaken to describe the ... |
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| A Novel Pathway to Down-Regulate ErbB Signaling in Mammary Epithelial |
JAN 2001 |
46 pages |
| Authors:
Lei Duan; Hamid Band; BRIGHAM AND WOMEN'S HOSPITAL BOSTON MA
|
| Activation of tyrosine kinases plays a key role in cell proliferation, and ErbB receptor tyrosine kinases are specifically implicated in breast cancer. Biochemical studies have recently identified the proto-oncogene product Cbl as a negative regulator of EGF receptor and ErbB2. The Cbl-dependent negative regulation of ErbB receptors was associated with their ubiquitin modification and downregulation from the cell surface. Based on these observations, this proposal is investigating the role of ... |
|
| Ultrasound Imaging Initiative |
JAN 2001 |
68 pages |
| Authors:
J. F. Cornhill; Geoffrey Lockwood; Christopher Hazard; CLEVELAND CLINIC FOUNDATION OH
|
| This objective of this project is to build a real-time 3D ultrasound-imaging system for combat casualty care. The high frame rate necessary for real-time 3D imaging is obtained using a synthetic aperture beamforming technique. The technique uses a fraction of the transmit pulses required by a conventional imaging system and permits very rapid image acquisition with no degradation of image quality. A beamformer capable of generating data for real-time 3D ... |
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| China and Its Environment |
2001 |
22 pages |
| Authors:
Teresa Barrett; NATIONAL WAR COLL WASHINGTON DC
|
| Former President Bill Clinton referred to the relationship with China as one that, "...will in large measure help to determine whether the new century is one of security, peace, and prosperity for the American people." The Clinton administration further defined environmental threats as posing threats to US security and well being, as stated in the opening quote. China has focused significant effort on economic development to improve its position as ... |
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| Modeling of the Carrier Mobility at the Silicon Oxynitride-Silicon Interface |
2001 |
5 pages |
| Authors:
K. J. Plucinski; MILITARY UNIV OF TECHNOLOGY WARSAW (POLAND)
|
| The main issue which is yet to be resolved in further developing the Surface Channel MOSFETs (SCMOSFETs) is understanding and eliminating deterioration of the carrier mobility at the insulator-semiconductor interface. The main factor causing this deterioration is hole and electron trapping-detrapping. One of the ways recently suggested of minimizing hole and electron trapping-detrapping at the Si-SiO2 interface involves replacing the SiO2 by silicon oxynitride (SiON). However degradation of MOSFETs, which ... |
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| MDVA: A Distance-Vector Multipath Routing Protocol |
2001 |
9 pages |
| Authors:
Srinivas Vutukury; J. J. Garcia-Luna-Aceves; CALIFORNIA UNIV SANTA CRUZ DEPT OF COMPUTER ENGINEERING
|
| Routing protocols using the Distributed Bellman-Ford (DBF) algorithm converge very slowly to the correct routes when link costs increase, and in the case where a set of link failures results in a network partition, DBF simply fails to converge, a problem that is commonly referred to as the count-to-infinity problem. In this paper, the authors present the first distance vector routing algorithm, the Multipath Distance-Vector Algorithm (MDVA), that uses a ... |
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| Accelerated Solvent Extraction for Sample Preparation of Chemical Weapon Degradation Compounds |
2001 |
20 pages |
| Authors:
Jay D. Sheffer; Spiros Z. Manolakos; Donna E. Swartz; CONSTELLATION TECHNOLOGY CORP LARGO FL
|
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| Effects of Cleaning of Coated Tedlar Samples on Space Environmenta1 Performance |
15 DEC 2000 |
16 pages |
| Authors:
W. K. Stuckey; M. J. Meshishnek; D. J. Coleman; AEROSPACE CORP EL SEGUNDO CA
|
| A space environment exposure test has been performed on samples of Cloud White Tedlar with a multi-layer thin-film coating on the surface applied by Optical Coatings Laboratory, Inc. (OCLI) representing potential spacecraft applications. This test was performed to simulate a LEO ultraviolet (UV) exposure on a subset of samples representative of a piece of space hardware that had inadvertently been exposed to water. A test was needed to provide data ... |
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| Feasibility and Genetic Algorithms: The Behaviour of Crossover and Mutation |
DEC 2000 |
|
| Authors:
Darryn J. Reid; DEFENCE SCIENCE AND TECHNOLOGY ORGANISATION SALISBURY (AUSTRALIA) ELECTRONICS AND SURVEILLANCE RESEARCH
|
| New genetic operators are described that assure preservation of the feasibility of candidate solutions to any discrete and linearly constrained optimisation problem. The design of these operators is the result of extensive theoretical investigations, with particular assiduity devoted to considering the most challenging examples of this type. Attention is largely centred on problems that have defied satisfactory solution by traditional means, because of poorly behaved or imprecise objective functions, high ... |
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| A Simulation Model for Managing Survivability of Networked Information Systems |
DEC 2000 |
|
| Authors:
SOumyo D. Moitra; Suresh L. Konda; CARNEGIE-MELLON UNIV PITTSBURGH PA SOFTWARE ENGINEERING INST
|
| In this paper the authors develop a model to evaluate the tradeoffs between the cost of defense mechanisms for networked systems and the resulting expected survivability after a network attack. The model consists of three submodels. The first submodel simulates the occurrence of attacks or incidents. The second submodel simulates the impact of an attack on the system. This depends on the type of attack and the defense mechanism installed ... |
|
| Degradation of Aliphatic and Aromatic Hydrocarbons by the Microbiota of Animal Burrow Wall Sediments |
30 NOV 2000 |
4 pages |
| Authors:
Gary M. King; MAINE UNIV AT WALPOLE DARLING MARINE CENTER
|
| The objective of our research was to document the extent to which burrowing macro fauna can be used to enhance biodegradation of aromatic hydrocarbon pollutants in marine sediments by stimulating aerobic microbial metabolism in burrow walls. Our specific objectives included characterizing degradation potentials for a variety of macrofauna. We also enriched and isolated relevant novel PAH-degrading bacteria and conducted manipulative experiments with them to ... |
|
| Space Environmental Performance of Optical Coatings on Tedlar |
15 NOV 2000 |
17 pages |
| Authors:
W. K. Stuckey; J. D. Barrie; M. J. Meshishnek; AEROSPACE CORP EL SEGUNDO CA LAB OPERATIONS
|
| A space environment exposure test has been performed on a variety of samples of Cloud White Tedlar with a multi-layer thin-film coating on the surface applied by Optical Coatings Laboratory, Inc. (OCLI) representing potential spacecraft applications. This test was performed to evaluate new coating formulations. The Tedlar coated with the new formulations was compared with previously coated Tedlar material. For the coated Tedlar on foam samples, the Ta205/ZrO2 configuration appeared ... |
|
| Mechanisms of Military Coatings Degradation - End of Fiscal Year 2000 Report |
NOV 2000 |
64 pages |
| Authors:
Anthony Eng; Forrest Pilgrim; Malay Patel; NAVAL SURFACE WARFARE CENTER CARDEROCK DIV PHILADELPHIA PA PHILADELPHIA DETACHMENT
|
| Although many distinguished scientists have studied the mechanisms of coating degradation and their relationship to service life, the need still exists to identify and elucidate these mechanisms in state-of-the-art military coating systems. Once accomplished, a predictive service life and life cycle cost can be optimally determined. In order to leverage this significant body of research and to comply with the multi-facility, tri-service, and academia- coordinated ... |
|
| QoS Negotiation in Real-Time Systems and its Application to Automated Flight Control |
NOV 2000 |
15 pages |
| Authors:
Tarek F. Abdelzaher; Ella M. Atkins; Kang G. Shin; VIRGINIA UNIV CHARLOTTESVILLE DEPT OF COMPUTER SCIENCE
|
| Real-time middleware services must guarantee predictable performance under specified load and failure conditions, and ensure graceful degradation when these conditions are violated. Guaranteed predictable performance typically entails reservation of resources and use of admission control. Graceful degradation, on the other hand, requires dynamic reallocation of resources to maximize the application-perceived system utility while coping with unanticipated overload and failures. We propose a model for quality-of-service (QoS) negotiation in building real-time ... |
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| Low-Level Sarion Neurotoxicity and its Modulation by Pyridostigmine |
OCT 2000 |
|
| Authors:
Barry W. Wilson; CALIFORNIA UNIV DAVIS
|
| A controversial epidemiological study of Gulf War veterans drew an association between a low-grade neurological syndrome (interpreted as OPIDN) and self-reported combined exposures to organophosphates (OPs, such as the chemical nerve agent sarin) and carbamates (such as the nerve agent antidote pyridostigmine bromide; PB) . The present experimental study employs biochemical, morphological and clinical endpoints to determine whether such combined exposures influence avian OP-induced delayed neuropathy (OPIDN) . Lethal doses ... |
|
| Environmental Exposure of Boron-Epoxy Composite Material |
OCT 2000 |
|
| Authors:
Roger Vodicka; DEFENCE SCIENCE AND TECHNOLOGY ORGANISATION MELBOURNE (AUSTRALIA)
|
| Boron-epoxy composite material (Textron 5521 F/4) was exposed at two tropical exposure sites within Australia for a period of about 3.5 years to evaluate the effects of outdoor exposure on mechanical properties. Specimens were exposed to three exposure types; fully exposed, covered and shaded. Moisture contents of 0.85% at Tindal N.T and 1.07% at AMRL-Q, Innisfail, QLD were found after about 3.5 years for the shaded and covered exposure conditions. ... |
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| Cannon Coating Erosion Model with Updated M829E3 Example |
OCT 2000 |
27 pages |
| Authors:
Samuel Sopok; ARMY ARMAMENT RESEARCH DEVELOPMENT AND ENGINEERING CENTER WATERVLIET NY BENET WEAPONS LAB
|
| Cannons with bore coatings are necessary to reduce erosion in current and future high-performance combat systems. In 1996, we developed a unique erosion model for cannons with bore coatings. Since that time, our results from this model have been published for a number of important Army and Navy gun systems with bore coatings. The erosion model for cannons with bore coatings is guided and calibrated and ... |
|
| Novel Breast Tumor Metalloproteinase Inhibitor |
OCT 2000 |
17 pages |
| Authors:
Michael J. Banda; CALIFORNIA UNIV BERKELEY LAWRENCE BERKELEY LAB
|
| Matrix Metalloproteinases (MMP) are a family of enzymes that degrade the extracellular matrix. Modulation of MMP activity may attenuate the invasiveness of some tumors. MMP activity may also be involved in breast tumor fibrosis because the balance of connective tissue synthesis and degradation is lost. Understanding factors that modulate MMP activity are therefore important to understanding breast tumor biology. We have identified a metalloproteinase inhibitor associated with an invasive breast ... |
|
| Nonlinear Ultrasound Image Modeling: Development of a Complete End-To- End Model for Qualitative and Quantitative Analysis of Medical Ultrasound |
28 SEP 2000 |
140 pages |
| Authors:
Kevin W. Ayer; AIR FORCE INST OF TECH WRIGHT-PATTERSONAFB OH
|
| Finite amplitude sound propagation undergoes nonlinear distortion due to continuous path interaction with the propagation medium. This distortion tends to defocus the beam causing significant lateral and contrast resolution degradation. Fundamental understanding of this interaction requires development of computational models that accurately predict the nonlinear interaction - development of media-borne harmonics - as well as produce an ultrasound image - introduction of transducer effects, interface ... |
|
| Study of Hydrophilic Zones to Improve the Performance of Organic Coatings. Heterogeneity of Polymer Film: Characterization and Protective Properties |
27 SEP 2000 |
40 pages |
| Authors:
D. Raghavan; HOWARD UNIV WASHINGTON DC DEPT OF CHEMISTRY
|
| Characterization of heterogeneous phases in polymers and hydrophilic regions in coatings have been the subject of AFOSR funded research project. Although hydrophilic regions occupy only a small fraction of the coating film volume. the hydrophilic regions control the corrosion protection performance of a polymer coating. At present the progress in the characterization of hydrophilic regions in coatings is very limited because of the lack ... |
|
| Dynamics of Hypervelocity Collisions at the Gas/Surface Interface |
SEP 2000 |
24 pages |
| Authors:
Dennis C. Jacobs; NOTRE DAME UNIV IN
|
| A series of hyperthermal energy, ion/surface scattering experiments were performed. These studies examined and characterized some of the many processes occurring in energetic gas/surface collisions. In the scattering of Ne+ on Si(001), the precise amount of momentum, transferred to the surface upon collision, was measured under various conditions. Models that incorporate image charge interactions and inelastic energy loss were successfully applied to simulate the data. The first measurement of atom ... |
|
| Inhibition of Breast Cancer by Repression of Angiogenic Hypoxia- Inducible Transcription Factors |
SEP 2000 |
27 pages |
| Authors:
Atul Bedi; JOHNS HOPKINS UNIV BALTIMORE MD SCHOOLOF MEDICINE
|
| The key transcritional regulators of the cellular hypoxic response, Hypoxia inducible Factor-1 (HIF- 1) and NF- kB, are responsible for induction of genes that regulate anaerobic metabolism, cell survival, and angiogenesis. We hyothesize that cancer cells subvert vert these normal hypoxia-de pendent mechanisms to enable their own deregulated survival, neovasculogenesis, and growth. We propose that at inhibition of HIF-1 and/or NF-kB can abrogate the angiogenic and apoptosis-resistant phenotype of breast ... |
|
| The Regulation of Human Cyclin E Protein Levels by the Ubiquitin Proteolytic Pathway |
SEP 2000 |
15 pages |
| Authors:
Jeffrey D. Stinger; James M. Roberta; FRED HUTCHINSON CANCER RESEARCH CENTERSEATTLE WA
|
| Cyclins are proteins that both activate cyclin-dependent kinases, enzymes that put phosphate groups on proteins, and impart some degree of substrate specificity to these kinases. Although very little is known about what these substrates are, it is clear that the regulation of levels of cyclins is crucial for cell cycle progression, that is cell growth. The human cyclin E protein has been shown to be required for the O1/S transition, ... |
|
| AP-1 Activity in Tamoxifen-Resistant Human Breast Tumors |
SEP 2000 |
13 pages |
| Authors:
Judy N. Quong; Christopher C. Benz; CALIFORNIA UNIV SAN FRANCISCO
|
| The hormonal therapy of choice for the treatment of breast cancer has been the antiestrogen tamoxifen. However, tumors eventually acquire a tamoxifen-resistant or tamoxifen-stimulated phenotype, resulting in disease recurrence. Estrogen receptor (ER) is known to interact with other transcription factors such as AP-l through protein-protein interactions. AP-1 responds to a variety of extracellular signals, including oxidative stress and growth factor stimulation and regulates a variety of genes that could be ... |
|
| Conference "Macromolecular Transport Across Cellular Membranes" |
SEP 2000 |
|
| Authors:
Robert Jensen; AMERICAN SOCIETY FOR MICROBIOLOGY WASHINGTON DC
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| Partial Contents: How are Macromolecules Selected and Targeted for Translocation?, Molecular Recognition of Newly Synthesized Peroxisomal Proteins Protein, and Peptide Translocation from the ER Lumen to the Cytosol, GTP- Dependence of Signal Recognition Particle Binding to Ribosome-bound Signal Sequences, How are Macromolecules Selected and Targeted for Translocation?, A family of Receptors for Targeting Preproteins to Chloroplasts, Characterization and Subcellular Localization of the Peroxisomal Membrane Protein, PMP5O, The Physiological Basis for ... |
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