| Expedited Citizenship through Military Service: Policy and Issues |
30 SEP 2003 |
|
| Authors:
Margaret Mikyung Lee; Ruth E. Wasem; LIBRARY OF CONGRESS WASHINGTON DC CONGRESSIONAL RESEARCH SERVICE
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 | Since the events of September 11, 2001, and the war against terrorism started with Operation Enduring Freedom and Operation Noble Eagle, there has been interest in legislation to expand the citizenship benefits of aliens serving in the military, which has increased considerably since the beginning of Operation Iraqi Freedom in March 2003. The reported deaths in action of noncitizen soldiers have drawn attention to provisions of the Immigration and Nationality ... |
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| Sudan: Humanitarian Crisis, Peace Talks, Terrorism, and U.S. Policy |
24 SEP 2003 |
|
| Authors:
Ted Dagne; LIBRARY OF CONGRESS WASHINGTON DC CONGRESSIONAL RESEARCH SERVICE
|
| Sudan has been ravaged by civil war intermittently for 4 decades. An estimated 2 million people have died over the past two decades due to war-related causes and famine, and millions have been displaced from their homes. The 20-year civil war continues to be a major contributing factor to recurring humanitarian crisis. There have been many failed attempts to end the civil war in southern Sudan, including efforts by Nigeria, ... |
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| Iraq: Summary of U.S. Casualties |
23 SEP 2003 |
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| Authors:
Glenda Richardson; LIBRARY OF CONGRESS WASHINGTON DC CONGRESSIONAL RESEARCH SERVICE
|
| The following casualty table was compiled by the Department of Defense (DoD), as tallied from DoD press releases. Table 1 provides statistics on fatalities during Operation Iraqi Freedom, which began on March 19, 2003, and is ongoing, as well as on the number of fatalities since May 1, 2003. Statistics may be revised as circumstances are investigated and as all records are processed through the U.S. military's casualty system. This ... |
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| USF-2 as an Inhibitor of Mammary Gland Carcinogenesis |
SEP 2003 |
15 pages |
| Authors:
Darryl L. Hadsell; BAYLOR COLL OF MEDICINE HOUSTON TX
|
 | The hypothesis tested in these studies is that overexpression of USF in the mammary glands of transgenic mice will inhibit myc-dependent tumorigenesis. Expression of a FLAG-tagged form or USF-2 was targeted to the mammary gland under the control of the mouse mammary tumor virus (mmtv) long terminal repeat. Of eight lines of transgenic mice that were generated, one demonstrated expression of flag-tagged USF-2 in the lactating mammary gland at levels ... |
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| Therapeutic and Chemopreventive Actions of a Novel Polyamine Analog Against Breast Cancer |
SEP 2003 |
43 pages |
| Authors:
Nancy E. Davidson; JOHNS HOPKINS UNIV BALTIMORE MD SCHOOLOF MEDICINE
|
| The intracellular polyamines, spermidine, spermine, and putrescine, play an important role in the proliferation and death of normal and malignant cells. As a consequence, our work has focused on development of inhibitors of this metabolic pathway. A phase II trial of diethylnorspermine (DENSpm) for women with advanced breast cancer was completed. No major toxicity was observed but clinical activity was not sufficient to warrant further testing of DENSpm at the ... |
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| Neuroprotective Ganglioside Derivatives |
SEP 2003 |
25 pages |
| Authors:
M. D. Ullman; MASSACHUSETTS UNIV MEDICAL SCHOOL WORCESTER
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| In this study, neuroprotective ganglioside derivatives are examined so they can be targeted to specific points in cell death pathways. Here, ganglioside functional groups required for neuroprotection and blood-brain barrier permeance are determined. Cell death mechanisms and the mechanism(s) by which semisynthetic gangliosides intervene in the cell death process are also studied. In the second year C2, C4, CS, C14, C20, and C26 fatty acid GMl derivatives were synthesized. Experiments ... |
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| Identification and Characterization of Components of the Mitotic Spindle Checkpoint Pathway in Fission Yeast |
SEP 2003 |
26 pages |
| Authors:
Sheila Kadura; Shelly Sazer; BAYLOR COLL OF MEDICINE HOUSTON TX
|
| During anaphase of mitosis, sister chromatids are separated by the mitotic spindle. The spindle assembly checkpoint protects the integrity of the genome by initiating a cell cycle delay if chromosomes are not property attached to the spindle. Cells lacking a functional spindle checkpoint may gain or lose genetic information, which can cause cell death or predispose cells to cancer. For example, mutations in human Bub1 p have been identified in ... |
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| Mechanisms of Resistance to Neurotoxins (Addendum) |
SEP 2003 |
22 pages |
| Authors:
David R. Schubert; SALK INST FOR BIOLOGICAL STUDIES LA JOLLA CA
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| The toxicity of chemically reactive oxygen species (ROS) is thought to make a significant contribution to the death of nerve cells caused by many neurotoxins as well as in stroke and Parkinson's disease. During all of these events, some groups of nerve cells are spared relative to others. It is therefore likely that biochemical mechanisms exist which lead to increased resistance to oxidative stress and other forms of cytotoxicity. It ... |
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| DNA Vaccine for West Nile Virus Infection in Fish Crows (Corvus ossifragus) |
SEP 2003 |
6 pages |
| Authors:
Michael J. Turell; Michel Bunning; George V. Ludwig; Brian Ortman; Jeff Chang; ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD VIROLOGY DIV
|
| A DNA vaccine for West Nile virus (WNV) was evaluated to determine whether its use could protect fish crows (Corvus ossifragus) from fatal WNV infection. Captured adult crows were given 0.5 mg of the DNA vaccine either orally or by intramuscular (IM) inoculation; control crows were inoculated or orally exposed to a placebo. After 6 weeks, crows were challenged subcutaneously with 105 plaque-forming units of WNV (New York 1999 strain). ... |
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| Autonomic and Hemodynamic Correlates of Daily Life Activity and Ambulatory Myocardial Ischemia in Patients with Stable Coronary Artery Disease |
20 AUG 2003 |
148 pages |
| Authors:
John F. Quigley; UNIFORMED SERVICES UNIV OF THE HEALTH SCIENCES BETHESDA MD DEPT OF MEDICAL AND CLINICAL PSYCHOLOGY
|
| Impaired autonomic-cardiac regulation, as defined by reduced levels of heart rate variability (HRV), is an independent predictor of death in patients with coronary artery disease (CAD) and a history of myocardial infarction. Moreover, transient shifts in HRV have been observed before the acute onset of ambulatory myocardial ischemia in CAD patients. The present study investigated whether or not changes in autonomic-cardiac regulation: (1) were associated with altered hemodynamic regulation in ... |
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| Suits Against Terrorist States by Victims of Terrorism |
08 AUG 2003 |
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| Authors:
David M. Ackerman; LIBRARY OF CONGRESS WASHINGTON DC CONGRESSIONAL RESEARCH SERVICE
|
| In 1996 Congress amended the Foreign Sovereign Immunities Act (FSIA) to allow U.S. victims of terrorism to sue the states responsible for terrorist acts. That politically popular initiative has subsequently become very complex. The terrorist state defendants have refused to appear in court, the courts have handed down large default judgements, the Clinton and Bush Administrations have intended to block various steps to collect on those judgments. and Congress has ... |
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| Are Microtubules Involved in Anoikis? |
AUG 2003 |
23 pages |
| Authors:
Steven M. Frisch; BURNHAM INST LA JOLLA CA
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| This project is investigating the role of microtubule alterations in anoikis, with a view toward re-examining the mechanism of microtubule-targeting drugs such as taxol. During the past year, we have uncovered a new mechanism by which cell adhesion controls apoptosis. The death receptor adaptor protein FADD (FAS-associated death domain protein) is critical for anoikis as well as death ligand (e.g., FASL) induced apoptosis. Recently, we discovered that FADD is primarily ... |
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| Kainate Receptors in the Striatum: Implications for Excitotoxicity in Huntington's Disease |
AUG 2003 |
12 pages |
| Authors:
Yoland Smith; EMORY UNIV ATLANTA GA
|
| Huntington's disease (HD) is a neurodegenerative condition characterized by a loss of projection neurons in the striatum. Although various hypotheses have been proposed to explain the mechanisms that underlie the striatal neuronal death, excitotoxicity still deserves major interest. Recent findings indicate that changes in the genotype of the kainate receptor subunit, GluR6, are associated with variation in the age of onset of HE), which implicates the kalnate receptors in the ... |
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| A Molecular Connection Between Breast Cancer Proliferation and Metastasis Mediated by Akt Kinase |
AUG 2003 |
31 pages |
| Authors:
Georg F. Weber; NEW ENGLAND MEDICAL CENTER HOSPITAL BOSTON MA
|
| Death from cancer is most frequently caused by metastases. While research of the past 20 years has identified genes whose malfunction causes cancer to grow. It has not been clear why these defects also induce the ability to metastasize. We have defined molecules that form a connection between signals that make cancer cells grow and signals that cause them to metastasize. In breast cancer cells, a molecule called Akt kinase ... |
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| Evaluation of Triple Containment Method for Air Transport of Contaminated Human |
AUG 2003 |
34 pages |
| Authors:
James S. Neville; Lance L. Annicelli; Dale D. Thomas III; AIR FORCE INST FOR OPERATIONAL HEALTH BROOKS CITY-BASE TX SURVEILLANCE DIRECTORATE
|
| A triple containment system intended for transport of biologically contaminated human remains was tested for its ability to maintain integrity during exposure to altitude changes representative of air transport. The system consisted of commercially available products; BioSeal(registered) material, a Ziegler case, and a Batesville casket. Each was tested individually and as a system. The BioSeal(registered) material was robust but did not maintain a seal in all tests. The Ziegler case ... |
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| Reaper-Induced Cytochrome C Release |
AUG 2003 |
24 pages |
| Authors:
Michael R. Olson; DUKE UNIV DURHAM NC
|
| Apoptosis is a program of cellular suicide which leads to the removal of damaged or superfluous cells without damaging overall tissue architecture. This grant concerns apoptotic induction by a 65 amino acid protein called Reaper form Drosophila melanogaster. Reaper was originally identified in a screen for critical apoptotic regulators in flies and it was later shown by our lab and others the Reaper can induce cell death upon ectopic expression ... |
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| Inflammatory Response and Oxidate Stress in the Degeneration of Dopamine Neurons in Parkinson's Disease |
AUG 2003 |
65 pages |
| Authors:
C. W. Olanow; MOUNT SINAI SCHOOL OF MEDICINE NEW YORK
|
| Parkinson's disease is characterized by the depletion of glutathione (GSH) in, the substantia nigra and the degeneration of nigral dopamine neurons. In our stud: we examined the relationship between cellular GSH depletion and neuronal degeneration. Using rat mesencephalic cultures as a model, we found that GSH depletion results in phospholipase A, (PLA(sub 2))-dependent release of arachidonic acid and increase in lipoxygenase (LOX-dependent arachidonic acid metabolism. These events generate reactive oxygen ... |
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| Sudan: Humanitarian Crisis, Peace Talks, Terrorism, and U.S. Policy |
18 JUL 2003 |
|
| Authors:
Ted Dagne; LIBRARY OF CONGRESS WASHINGTON DC CONGRESSIONAL RESEARCH SERVICE
|
| Sudan has been ravaged by civil war intermittently for 4 decades. An estimated 2 million people have died over the past two decades due to war-related causes and famine, and millions have been displaced from their homes. The 20-year civil war continues to be a major contributing factor to recurring humanitarian crisis. There have been many failed attempts to end the civil war in southern Sudan, including efforts by Nigeria, ... |
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| Preventing the Consequences of Alcohol Abuse: Identification of Soldiers at High Risk for Fatal and Serious Injuries |
JUL 2003 |
24 pages |
| Authors:
Nicole S. Bell; SOCIAL SECTORS DEVELOPMENT STRATEGIES INC BOSTON MA
|
| The main goal of this study is to improve our understanding of the relationship between alcohol problems and risk of serious injury by documenting the prevalence of alcohol-related diagnoses among soldiers admitted to the hospital with and without injuries. In this study's first year we have formulated diagnostic criteria for identifying alcohol- and injury-related hospitalizations and verified the continuity of diagnostic codes between the ICD-9 and the ICD-9-CM. Additionally, we ... |
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| Molecular Mechanisms of Metastatic Progression in Breast Cancer |
JUL 2003 |
16 pages |
| Authors:
Louise A. Flanagan; NOTRE DAME UNIV IN
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| Clusterin is a multifunctional disulphide linked protein that is induced during regression of hormone dependent tissues. of particular interest to us is the observation that clusterin expression is confined to surviving cells following induction of cell death, suggesting that it may be involved in cell survival rather than cell death. Clusterin expression has also been correlated with tumor grade and resistance to cytotoxic compounds such as TNF- alpha in prostate ... |
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| Novel Histone Deacetylase Inhibitors |
JUL 2003 |
66 pages |
| Authors:
Jeannie S. Strobl; WEST VIRGINIA UNIV RESEARCH CORP MORGANTOWN*
|
| HDAC (histone deacetylase) is a novel target for anti-cancer drug discovery. A database of guinoline compounds was characterized for the ability to inhibit HDAC, promote differentiation and cell death in tissue culture lines of human breast cancer. Antimalarials, chloroquine and quinidine promote breast tumor cell differentiation and cell death. A novel mechanism, regulation of HDAC1 by stimulating ubiguitination and proteasomal degradation of HDAC1 is proposed to explain the actions of ... |
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| Apoptotic Regulation |
JUL 2003 |
9 pages |
| Authors:
David A. Richardson; Sally A. Kornbluth; DUKE UNIV MEDICAL CENTER DURHAM NC
|
| Reaper is a potent inducer of apoptotic cell death in the fruit fly Drosoophila melanogaster. Our lab unexpectedly discovered that Reaper also induces apoptosis in cultured human cells and cell free extracts prepared using eggs from the frog Xenopus laevis. In the Xenopus model system Reaper must bind another protein, Scythe, to induce apoptosis. Scythe forms a stable complex with the chaperone protein Hsp70 and inhibits its activity. Upon Reaper-Scythe ... |
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| Regulation of Apoptosis in Breast Cancer by NF-KappaB and IAB Axis |
JUL 2003 |
28 pages |
| Authors:
BURNHAM INST LA JOLLA CA
|
| Defects in apoptosis contribute to the pathogenesis and progression of breast cancer. One of the modulators of apoptosis is NF-KappaB, a family of heterodimeric transcription factors containing a conserved REL homology domain. Apoptosis relevant targets of NF-KappaB include Bfl-1, bcl-X(sub L), FLIP, cIAP2, and others. We sought to identify novel regulators of NF-KappaB. We identified novel members of a family of PAAD/PYRIN domain-containing proteins, called PAs2 and NAC. These proteins ... |
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| Phosphatidylinositol 3-Kinane and Protein Kinase C as Molecular Determinants of Chemoresistance in Breast Cancer |
JUL 2003 |
11 pages |
| Authors:
Amanda P. Parker; Barbara Beckman; TULANE UNIV HEALTH SCIENCE CENTER NEW ORLEANS LA
|
| The goal of this study is to investigate the role of Pl3K and PKC in chemoresistance in breast cancer and to use this information to identify novel therapeutic strategies aimed at counteracting or reversing drug resistance in breast cancer. We are using an isogenic model of breast cancer resistance with apoptosis-sensitive and apoptosis-resistant MCF-7 cells. Our preliminary data implicate the absence of PKC alpha, and a constitutive activation of the ... |
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| Sudan: Humanitarian Crisis, Peace Talks, Terrorism, and U.S. Policy |
04 JUN 2003 |
|
| Authors:
Ted Dagne; LIBRARY OF CONGRESS WASHINGTON DC CONGRESSIONAL RESEARCH SERVICE
|
| Sudan has been ravaged by civil war intermittently for 4 decades. An estimated 2 million people have died over the past two decades due to war-related causes and famine, and millions have been displaced from their homes. The 20-year civil war continues to be a major contributing factor to recurring humanitarian crisis. There have been many failed attempts to end the civil war in southern Sudan, including efforts by Nigeria, ... |
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| Organic Isothiocyanates: Dietary Modulators of Doxorubicin Resistance in Breast Cancer |
JUN 2003 |
120 pages |
| Authors:
Marilyn E. Morris; STATE UNIV OF NEW YORK COLL AT BUFFALO
|
| Drug resistance is the main cause for therapeutic failure and death in breast cancer. Our goal is to evaluate dietary organic isothiocyanates (ITCs) as inhibitors of MDR. Our studies have demonstrated that phenethyl ITC (PEITC), benzyl ITC (BITC) and naphthyl ITC (NITC) can inhibit P-glycoprotein-mediated efflux in cell lines that overexpress P-gp, as well as in cell lines that overexpress another MDR protein, Multidrug Resistance-associated protein (MRP1). Studies evaluating the ... |
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| Novel Role of ANX7 in Breast Cancer Progression |
JUN 2003 |
18 pages |
| Authors:
Meera Srivastava; HENRY M JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE ROCKVILLEMD
|
| The ANX7 gene codes for a Ca(2+) -activated GTPase, and is a tumor suppressor gene ANX7 expression has prognostic value for predicting survival of breast cancer patients. Our objective in this proposal is to determine the mechanism and the signaling pathway by which the ANX7 gene induces death of breast cancer cells. To this end, we have generated and identified the dominant negative mutants against calcium and GTP in the ... |
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| Functions of Human Rad51 and Other Recombination Factors in DNA Double- Strand Break Repair |
JUN 2003 |
18 pages |
| Authors:
Stefan Sigurdsson; TEXAS UNIV HEALTH SCIENCE CENTER AT SANANTONIO
|
| The genetic material of all cells is frequently damaged by both exogenous and endogenous factors. Cells have evolved distinct mechanisms to remove different types of DNA damage. Perhaps the most serious form of DNA damage is the double strand break, where both the DNA strands are broken. This type of DNA lesion, if left intact, can lead to cell death, chromosomal translocations, chromosome loss and cancer. The accurate repair of ... |
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| Reduction of Radiation- or Chemotherapy-Induced Toxicity by Specific Expression of Anti-Apoptotic Molecules in Normal Cells |
JUN 2003 |
13 pages |
| Authors:
Naoto T. Ueno; M D ANDERSON CANCER CENTER HOUSTON TX
|
| Adjuvant radiation and chemotherapy confer a survival benefit in breast cancer, but both treatments can damage normal tissues in ways that can adversely affect quality of life (e.g., by skin desquamation, mucositis, pulmonary fibrosis, cardiomyopathy, peripheral neuropathy). These effects on normal tissues are generally due to apoptosis (programmed death) of normal cells. We hypothesize that ectopic overexpression of the anti-apoptotic molecule Bcl-2 will inhibit the radiation-induced apoptosis of normal cells ... |
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| Characterization and Modulation of Proteins Involved in Sulfur Mustard Vesication |
MAY 2003 |
65 pages |
| Authors:
Dean S. Rosenthal; GEORGETOWN UNIV WASHINGTON DC
|
| To develop medical countermeasures for exposure of military personnel and civilians, we defined the molecular series of events leading to SM vesication. We made significant headway in elucidating several important pathways by which SM induces cell death in cultured keratinocytes and dermal fibroblasts, as well as in intact mouse and grafted human skin. During the granting period, we found that SM induces markers of terminal differentiation as well as apoptosis ... |
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| Molecular Biology Basis for the Response of Poly(ADP-ribose) Polymerase and NAD Metabolism to DNA Damage Caused by Mustard Alkylating Agents |
MAY 2003 |
31 pages |
| Authors:
Mark E. Smulson; GEORGETOWN UNIV WASHINGTON DC
|
| PARP is a chromatin bound enzyme, which is pivotal in the recovery of cells from DNA strand break damage. SM confers damage to cells causing DNA strand breaks. In collaboration with intramural scientists of USAMRICD, we recently demonstrated that SM, in part, causes cellular pathology and death via initiating apoptosis, and in primary PARP (+/+) fibroblasts by causing such an extensive depletion of ATP and NAD that the skin cells ... |
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| The Role of Phosphorylation in the Regulation of p27 Function in Breast Cancer |
MAY 2003 |
37 pages |
| Authors:
Michael K. Connor; Joyce M. Slingerland; SUNNYBROOK AND WOMENS COLL HEALTH SCIENCES CENTER TORONTO (ONTARIO)
|
| Breast Cancer is a tragic disease that affects an increasing number of North American women each year. Although much is known about the disease, it appears this knowledge merely touches the surface of the mechanisms which underlie disease progression, often leading to patient death. Loss of the cell cycle inhibitor p27 in Breast Cancer Cells is known to be associated with advanced stage disease progression and poor patient prognosis. However, ... |
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| Sudan: Humanitarian Crisis, Peace Talks, Terrorism, and U.S. Policy |
23 APR 2003 |
|
| Authors:
Ted Dagne; LIBRARY OF CONGRESS WASHINGTON DC CONGRESSIONAL RESEARCH SERVICE
|
| Sudan has been ravaged by civil war intermittently for 4 decades. An estimated 2 million people have died over the past decade due to war-related causes and famine, and millions have been displaced from their homes. The 20-year civil war continues to be a major contributing factor to recurring humanitarian crisis. There have been many failed attempts to end the civil war in southern Sudan, including efforts by Nigeria, Kenya, ... |
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| Early Warning Flood Stage Monitoring Equipment |
APR 2003 |
6 pages |
| Authors:
Christopher Williams; COLD REGIONS RESEARCH AND ENGINEERING LAB HANOVER NH
|
| Communities built along both large and small rivers can be threatened by flooding and the associated potential for loss of life and personal property. whether resulting front heavy rains, snowmelt, ice jams, or combinations of these, flooding can occur unpredictably and without warning. An advanced early flood warning system could prevent fatalities and loss of personal property. The Engineering Resources Branch of the Engineer Research and Development Center's Cold Regions ... |
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| Exploiting and NQ01-Directed, Calpain-Medicated Apoptotic Pathway for Breast Cancer Therapy |
APR 2003 |
92 pages |
| Authors:
Mark W. Wagner; David A. Boothman; CASE WESTERN RESERVE UNIV CLEVELAND OH
|
| The purpose of this proposal was to further understand the molecular mechanisms of beta-lap-induced apoptosis, and its ability to target cancer over normal cells. We believe that beta-lap induces apoptosis through changes in intracellular calcium homeostasis and micron-calpain activation. This will be tested via two specific aims using NQ01-expressing and non-expressing (beta-lap sensitive and resistant, respectively) MDA-MB-468 breast cancer cells as a model system. The first aim was to determine ... |
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| Structural Basis for the Pharmacological Rescue of Mutant p53 With Small Molecule Compounds |
APR 2003 |
13 pages |
| Authors:
William C. Ho; PENNSYLVANIA UNIV PHILADELPHIA WISTAR INST
|
| The p53 protein is a tumor suppressor crucial to maintaining genomic integrity. In the event of DNA (damage, p53 is responsible for transcribing genes leading to cell death. A class of mutations which occur in the core domain (102-292) leads to thermodynamic destabilization and inability to bind its cognate DNA sequence. Small molecules which bind to and stabilize mutant p53 core domain have potential to be therapeutically useful. A class ... |
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| Air University Research Paper: Asymmetric Warfare - Exposing America's Weaknesses |
APR 2003 |
35 pages |
| Authors:
Bradley A. Kinneer; AIR UNIV PRESS MAXWELL AFB AL
|
| The morning of September 11, 2001 changed the face of America. Terrorism is no longer a word reserved for television broadcasters when describing events taking place halfway around the world. Watching the smoke billowing into the clear blue skies that September day Americans knew that we were on longer safe at home or at work. Terrorism had come to America. This abstract idea of killing innocent people which has always ... |
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| Patterns of Global Terrorism 2002 |
APR 2003 |
188 pages |
| Authors:
DEPARTMENT OF STATE WASHINGTON DC
|
| This report is submitted in compliance with Title 22 of the United States Code, Section 2656f(a), which requires the Department of State to provide Congress a full and complete annual report on terrorism for those countries and groups meeting the criteria of Section (a)(1) and (2) of the Act. As required by legislation, the report includes detailed assessments of foreign countries where significant terrorist acts occurred, and countries about which ... |
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| Sudan: Humanitarian Crisis, Peace Talks, Terrorism, and U.S. Policy |
05 MAR 2003 |
|
| Authors:
Ted Dagne; LIBRARY OF CONGRESS WASHINGTON DC CONGRESSIONAL RESEARCH SERVICE
|
| Sudan has been ravaged by civil war intermittently for 4 decades. An estimated 2 million people have died over the past decade due to war-related causes and famine, and millions have been displaced from their homes. The 20-year civil war continues to be a major contributing factor to recurring humanitarian crisis. There have been many failed attempts to end the civil war in southern Sudan, including efforts by Nigeria, Kenya, ... |
|
| Endometase in Androgen-Repressed Human Prostate Cancer |
MAR 2003 |
58 pages |
| Authors:
Qing-Xiang A. Sang; FLORIDA STATE UNIV TALLAHASSEE
|
| The spread of prostate cancer cells to other parts of the body is the leading cause of patient death. In 2000, we reported the discovery, cloning, and characterization of human matrix metalloproteinase-26 (MMP-26), endometase. We have been testing three specific hypotheses: 1) The expression levels of MMP-26 is correlated with the metastatic potentials and the degrees of malignancy of human prostate cells; 2)MMP-26 has unique structure and enzymatic function; 3) ... |
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| Development of Anti-Cancer Therapeutics that Modulate the RAD51-BRCA2 Complex |
MAR 2003 |
9 pages |
| Authors:
Edward P. Hasty; TEXAS UNIV HEALTH SCIENCE CENTER AT SANANTONIO
|
| Cancer is one of the leading causes of death in America and breast cancer is particularly threatening for women In America 10% of women will be diagnosed with breast cancer resulting in the death of more than 40,000 of these women each year. Inheriting a single defect in genetic material causes about 5% of the cases of breast cancer and a gene that is commonly mutated in these familial cases ... |
|
| Emerging Concepts of Mortuary Affairs Doctrine for the 21st Century War Fighter |
27 FEB 2003 |
42 pages |
| Authors:
Frederic C. Ryder; AIR WAR COLL MAXWELL AFB AL
|
| This is a review of the Department of Defense's (DoD) Mortuary Affairs program. In the following pages it is my intent to determine if existing doctrine and planning is sufficient in the event the United States (US) is required to execute a wartime mortuary operation. For years Mortuary Affairs has corporately wrestled with the notion that friendly troops could be killed by, or contaminated by, weapons of mass effect (WME), ... |
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| Spatial Disorientation in Military Vehicles: Causes, Consequences and Cures (Desorientation spaiale dans les vehicules militaires: causes, consequences et remedes) |
FEB 2003 |
|
| Authors:
NATO RESEARCH AND TECHNOLOGY ORGANIZATION NEUILLY-SUR-SEINE (FRANCE)
|
| Spatial disorientation (SD), a condition in which the operator fails to sense correctly the position, motion or attitude of the vehicle or of him/ herself, continues to be a cause of aircraft accidents, with accident rates that, unlike the overall rate, have not fallen over the past 15 years. The Symposium was convened to review current knowledge of the causes of SD and preventative measures, applicable to air land and ... |
|
| Methylselenium and Prostate Cancer Apoptosis |
FEB 2003 |
26 pages |
| Authors:
Junxuan Lu; AMC CANCER RESEARCH CENTER LAKEWOOD CORESEARCH ADMINISTRATION
|
| The purpose of this research is to gain a better understanding of the biochemical pathways and molecular targets for the selective induction of apoptosis signaling and execution of PCa cells by methyl selenium (Se)/selenol We hypothesized that methyl inhibits PI3K-AKT survival pathway leading to the activation of caspase-dependent apoptosis execution in PCa cells We have in the reporting period refined a methylselenol generation system based on methioninase with selenomethionine as ... |
|
| Disorientation in Helicopter Ditching and Rigid Inflatable Boat Capsizement: Training is Essential to Save Crews |
FEB 2003 |
13 pages |
| Authors:
C. J. Brooks; SURVIVAL SYSTEMS LTD DARTMOUTH (NOVA SCOTIA)
|
| This paper discusses the disorientation problems of escape from a rigid inflatable boat (RIB) that has been capsized. It makes comparisons with executing a ditched helicopter underwater escape and emphasizes the need for realistic training for both RIB and helicopter crafts. Although very poor records are collected on RIB capsizements, each year there is a small but significant loss of life and many close calls. A paper at the Royal ... |
|
| Sudan: Humanitarian Crisis, Peace Talks, Terrorism, and U.S. Policy |
23 JAN 2003 |
|
| Authors:
Ted Dagne; LIBRARY OF CONGRESS WASHINGTON DC CONGRESSIONAL RESEARCH SERVICE
|
| Sudan has been ravaged by civil war intermittently for 4 decades. An estimated 2 million people have died over the past decade due to war-related causes and famine, and millions have been displaced from their homes. The 19-year civil war continues to be a major contributing factor to recurring humanitarian crisis. There have been many failed attempts to end the civil war in southern Sudan, including efforts by Nigeria, Kenya, ... |
|
| Peptide-Mediated Transduction of Proteins and Nucleic Acids to Prevent and Treat Experimental Prostate Cancer |
JAN 2003 |
10 pages |
| Authors:
Janey D. Whalen; PITTSBURGH UNIV PA
|
| Our goal in this project is to prevent the occurrence of bone metastasis in early experimental prostate cancer using protein transduction: the ability of small peptides to facilitate the entry of large biologically active fusion protein cargos into cells. The hypothesis to be tested is that protein transduction can deliver therapeutic proteins to skeletal tissues and bone marrow in such a manner that they may facilitate the apoptotic, or programmed ... |
|
| Formulated Delivery of Enzyme/Pro-Drug and Cytokine Gene Therapy to Promote Immune Reduction of Treated and Remote Tumors in Mouse Models of Prostate Cancer |
JAN 2003 |
14 pages |
| Authors:
Pamela J. Russell; Gerald W. Both; P. L. Molloy; T. Lockett; NEW SOUTH WALES UNIV SYDNEY (AUSTRALIA)
|
| Prostate cancer is the second highest cause of cancer death in Western society men. Early stages are treatable, but late stage disease is incurable with palliative care the only option. Purpose: We will use a combination of gene therapy approaches to target prostate cancer locally and in other organs (metastases). Gene directed enzyme/pro-drug therapy (GDEPT) is delivered in the prostate. This kills cancer cells and generates an immune reaction, To ... |
|
| International Conference on Parkinson's Disease |
JAN 2003 |
372 pages |
| Authors:
Rashid Shaikh; NEW YORK ACADEMY OF SCIENCES NY
|
| Partial Contents: Description of Parkinson's Disease as a Clinical Syndrome. Physiology and Pathophysiology of Parkinson's Disease. PET Studies on the Function of Dopamine in Health and Parkinson's Disease. Midbrain Dopaminergic Neurons: Determination of Their Developmental Fate by Transcription Factors. Transcriptional Control of Dopamine Neuron Development. Transcription Factors in the Development of Midbrain Dopamine Neurons. Postnatal Developmental Programmed Cell Death in Dopamine Neurons The Cast of Molecular Characters Parkinson's Disease: Felons,Conspirators, ... |
|
| Biological and Health Effects of Exposure to Kerosene-Based Jet Fuels and Performance Additives |
Jan 2003 |
99 pages |
| Authors:
Glenn D Ritchie; Kenneth R Still; John Rossi III; Marni Y Bekkedal; Andrew J Bobb; Darryl P Arfsten; NAVAL HEALTH RESEARCH CENTER WRIGHT-PATTERSON AFB OH TOXICOLOGY DETACHMENT
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| Over 2 million military and civilian personnel per year (over 1 million in the United States) are occupationally exposed, respectively, to jet propulsion fuel-8 ( JP-8), JP-8 + 100 or JP-5, or to the civil aviation equivalents Jet A or Jet A-1. Approximately 60 billion gallons of these kerosene- based jet fuels are annually consumed worldwide (26 billion gallons in the United States), including over 5 billion gallons of JP-8 ... |
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