Lipid-associated membrane proteins (LAMPs) exposed externally on the surface of mycoplasmas are responsible for inducing antibody responses during infections. We showed mycoplasmal LAMPs are species-specific. Antibodies to M. genitalium LAMPs detected by ELISA can be confirmed by Western Blotting and consistent with PCR results of patients' urines. We tested more than 1400 serum samples from patients with various diseases.
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