| Molecular Basis of Essential Thrombocytosis |
Jun-2008 |
90 pages |
| Authors:
Wadie F Bahou; STATE UNIV OF NEW YORK AT STONY BROOK RESEARCH FOUNDATION
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 | Human blood platelets play critical roles in normal hemostatic processes and pathologic conditions such as thrombosis (i.e. cardiovascular disease and stroke), vascular remodeling, inflammation, and wound repair. Despite the biological importance of platelets and their intact protein synthetic capabilities, remarkably little is known about platelet mRNAs. The pathogenesis of essential thrombocytosis (ET), a disease of platelet number and function, is poorly understood at the molecular level. The main goal of ... |
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| Synergism of Selective Tumor Vascular Thrombosis and Protease Activated Prodrug |
May-2008 |
33 pages |
| Authors:
Cheng Liu; SCRIPPS RESEARCH INST LA JOLLA CA
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| Targeted drug activation at selected site promises reduced toxicity and enhanced efficacy. We propose to investigate and validate a bipartite drug delivery-activation system that employs selective tumor vascular targeted induction of endogenous coagulation protease cascade followed by administration of protease-activated prodrug. The activation of coagulation cascade and tumor vascular thrombosis as well as the following activation of the thrombolytic pathways led to explosive amplification of serine protease cascades and local ... |
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| Molecular Basis of Essential Thrombocytosis |
01 JUN 2007 |
26 pages |
| Authors:
Wadie Bahou; STATE UNIV OF NEW YORK AT STONY BROOK
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| Human blood platelets play critical roles in normal hemostatic processes and pathologic conditions such as thrombosis (i.e. cardiovascular disease and stroke), vascular remodeling, inflammation, and wound repair. Despite the biological importance of platelets and their intact protein synthetic capabilities, remarkably little is known about platelet mRNAs. The pathogenesis of essential thrombocytosis (ET), a disease of platelet number and function, is poorly understood at the molecular level. The main goal of ... |
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| Quantitative Methods for Determining U.S. Air Force Crew Cushion Comfort |
SEP 2006 |
12 pages |
| Authors:
Julia Parakket; Joseph Pellettiere; David Reynolds; Manikandan Sasidharan; Muhamed El-Zoghbi; AIR FORCE RESEARCH LAB WRIGHT-PATTERSON AFB OH HUMAN EFFECTIVENESS DIRECTORATE
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| The detrimental effects of prolonged sitting during long-duration flights include deep vein thrombosis, pressure sores, and decreased awareness and performance. However, the cushion is often the only component of the ejection seat System that can be modified to mitigate these effects. This study investigated the long-duration effects of sitting in four ejection seat cushions over eight hours. Subjective comfort survey data and cognitive performance data were gathered along with comparative ... |
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| Identification, Cloning, Expression, and Characterization of the Gene for Plasmodium knowlesi Surface Protein Containing an Altered Thrombospondin Repeat Domain |
27 APR 2005 |
9 pages |
| Authors:
Babita Mahajan; Dewal Jani; Rana Chattopadhyay; Rana Nagarkatti; Hong Zheng; Victoria Majam; Walter Weiss; Sanjai Kumar; Dharmendar Rathore; FOOD AND DRUG ADMINISTRATION ROCKVILLE MD
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| Proteins present on the surface of malaria parasites that participate in the process of invasion and adhesion to host cells are considered attractive vaccine targets. Aided by the availability of the partially completed genome sequence of the simian malaria parasite Plasmodium knowlesi, we have identified a 786-bp DNA sequence that encodes a 262-amino-acid-long protein, containing an altered version of the thrombospondin type I repeat domain (SPATR). Thrombospondin type 1 repeat ... |
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| Measurement of Venous Blood Flow in the Lower Limbs: Prevention of Deep Vein Thrombosis during Prolonged Sitting |
JUN 2004 |
5 pages |
| Authors:
Hideki Oyama; Yuichi Ebine; Toshihiro Ando; Kageyu Noro; WASEDA UNIV TOKYO (JAPAN)
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| The venous blood flow during stretching and deep breathing in the sitting posture was examined in the present study. First, an inguinocrural venous blood flow was measured using the Doppler method. It was confirmed that the blood flow velocity significantly increased during stretching with deep breathing. Second, the peripheral blood circulation in the lower limbs was evaluated during a 60 min sitting session using a near infrared spectroscopy method. It ... |
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| Thromboxane Synthase and Prostate Cancer Progression |
JUL 2003 |
11 pages |
| Authors:
Kenneth V. Honn; WAYNE STATE UNIV DETROIT MI
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| The initiation and progression of prostate cancer remain not well understood to enable rational development of interventional therapy. Thromboxane synthase is an enzyme downstream cyclooxygenase, utilizing prostaglandin H to form thromboxane A2. Using immunohistochemistry analysis, we found that 25% of clinical prostate tumor specimens had strong expression of thromboxane synthase; 33% of cases had medium expression and 42% of cases had weak expression of thromboxane synthase. Prostate cancer cells isolated ... |
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| Effect of Segmented Polyurethane Coating on Thrombus Regulated With Pulsatile Shear Flow |
25 OCT 2001 |
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| Authors:
Shigehiro Hashimoto; Yoshinori Murashige; Atsushi Yamanaka; Hajime Otani; OSAKA INST OF TECHNOLOGY OHMIYA INFORMATION AND COMMUNICATION ENGINEERING
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 | The effect of segmented polyurethane coating on thrombus formation was quantitatively studied under shear field in vitro. The Couette-type of shear rate was applied to the canine blood between the concave and the convex cones, Variation was made about materials of cones: Polymethyl-methacrylate, polyvinyl chloride, and polyvinyl chloride coated with segmented polyurethane The study shows that the clotting time extends on the segmented polyurethane especially at the higher shear rates, ... |
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| Mathematical Model of Venous Occlusion Plethysmography for Diagnosing Deep Vein Thrombosis |
25 OCT 2001 |
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| Authors:
J. Lee; H. J. Noh; Y. R. Yoon; H. R. Yoon; K. J. Lee; YONSEI UNIV SEOUL (REPUBLIC OF KOREA)
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| Although the results of VOP can determine the being of DVT, it has difficulty in analyzing quantitatively the effects of the degrees of thrombosis, blood pressure and cuff pressure on VOP, in this paper, by developing a combined model that is composed of pulsatile cardiovascular model and venous occlusion model, we showed the availability of more realistic simulation, Using the proposed combined model in simulation about the effects of different ... |
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| Decreased Platelet Inhibition by Nitric Oxide in Two Brothers With a History of Arterial Thrombosis |
16 SEP 1995 |
41 pages |
| Authors:
J. E. Freedman; J. Loscalzo; S. E. Benoit; C. R. Valeri; M. R. Barnard; NAVAL BLOOD RESEARCH LAB BOSTON MA
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| Highly reactive oxygen species rapidly inactivate nitric oxide (NO), an endothelial product which inhibits platelet activation. We studied platelet inhibition by NO in two brothers with a cerebral thrombotic disorder. Both children had hyperreactive platelets, as determined by whole blood platelet aggregometry and flow cytometric analysis of the platelet surface expression of P-selectin. Mixing experiments showed that the patients' platelets behaved normally in control ... |
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| Evaluation of Dried Storage of Platelets for Transfusion: Physiologic Integrity and Hemostatic Functionality |
31 JAN 95 |
23 pages |
| Authors:
Arthur P. Bode; Majorie S. Read; Robert L. Reddick; EAST CAROLINA UNIV SCHOOL OF MEDICINE GREENVILLE NC
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| Currently, therapeutic platelet concentrates can be stored for only 5 days. We have developed a procedure that permits long term storage of fixed and lyophilized platelets that retain hemostatic properties after rehydration. These rehydrated lyophilized platelets (RL platelets) restore hemostasis in thrombocytopenic rats and become incorporated in the hemostatic plug of bleeding time wounds of normal dogs as well as von Willebrand disease dogs with partially replenished plasma von Willebrand ... |
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| Association of Protein S Deficiency with Thrombosis in a Kindred with Increased Levels of Plasminogen Activator Inhibitor-1 |
15 OCT 1993 |
9 pages |
| Authors:
Charles D. Bolan; Chitra Krishnamurti; Douglas B. Tang; Leonthena R. Carrington; Barbara M. Alving; WALTER REED ARMY INST OF RESEARCH WASHINGTON DC
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| The most common inherited abnormalities associated with familial venous thrombosis are deficiencies of protein S, protein C, and antithrombin III (1-3). All are inherited in an autosomal dominant manner and can result in venous thrombosis at young age. The most common of these three deficiencies is protein S, which circulates in a free from and in an inactive complex with C4b-binding protein. Only unbound or free protein S has functional ... |
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| Denatured Hemoglobin Increases Human Blood Mononuclear Cell Procoagulant Effect |
16 MAR 93 |
9 pages |
| Authors:
S. A. Kim; V. O. Villa; J. R. Hess; LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA
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| To study the effects of the common contaminants of hemoglobin solutions, red cell stroma, bacterial endotoxin, and denatured hemoglobin on the causes of the thrombotic lesions which have been reported in animal experiments after hemoglobin administration. Human blood mononuclear cells were isolated on Ficoll-Hypaque gradients and incubated with hemoglobin from the LAIR production facility, red cell stroma, bacterial endotoxin (E. Coli, Wittaker Bioproducts), and hemoglobin denatured by boiling. Incubations were ... |
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| Platelet-Endothelial Function in Relation to Environmental Temperature |
MAR 84 |
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| Authors:
S. P. Bruttig; G. D. Draper; M. P. Hamlet; ARMY RESEARCH INST OF ENVIRONMENTAL MEDICINE NATICK MA
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| Thromboembolic phenomena are commonly observed in frostbite injury to the microvasculature. Large blood vessel endothelium was used to assess any alterations in platelet-endothelial interaction resulting from low environmental temperatures. Media from bovine endothelial cells (37, 24, 4C) did not cause or enhance platelet aggregation. Yet ADP (120 micrometers) stimulated aggregation of all platelet samples. Bovine and porcine endothelial cells were incubated at 37, 24, 4, and 0.5C with homologous platelets ... |
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| Report on the Removal of Obstructions of Old Arterial Thromboses (Sur la des Obstruction des Thromboses Arterielles Anciennes), |
24 SEP 1976 |
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| Authors:
Jean Cid dos Santos; ARMY MEDICAL INTELLIGENCE AND INFORMATION AGENCY WASHINGTON D C
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| It was established that one could remove an old thrombus and, with heparin, keep the artery permeable while the collaterals remained utilizable. |
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| Absence of Hypoglycemia in Canine Splanchnic Arterial Occlusion (SAO) Shock. |
07 OCT 1975 |
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| Authors:
Linda T. Archer; Megan R. Black; Mary M. Lane; Lerner B. Hinshaw; OKLAHOMA UNIV HEALTH SCIENCES CENTER OKLAHOMA CITY
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| The primary purpose of the present study was to determine the role of glucose in splanchnic arterial occlusion (SAO) shock. The three major arteries to the splanchnic region: celiac, superior, and inferior mesenteric of dogs were occluded for a 90 to 120 minute period. Upon release of the occlusion, shock was manifested by marked hypotension, acidosis and hemoconcentration and was 100% lethal within 120 minutes although dextran (6%) was administered ... |
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| THROMBOPHLEBITIS AND BASIC VASCULAR PROBLEMS |
1967 |
35 pages |
| Authors:
III Hardaway Robert M.; WALTER REED ARMY INST OF RESEARCH WASHINGTON DC
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| The most important basic vascular problem is intravascular coagulation. This is caused by four main groups of factors: factors causing slow blood flow; factors causing hypercoagulability; substances initiating coagulation; and damage to the vascular endothelium. Knowing these factors, intravascular coagulation can be minimized by various measures to prevent thrombophlebitis. |
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| SOVIET CLINICAL MEDICINE: (SELECTED) TRANSLATIONS. |
05 APR 1963 |
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| Authors:
JOINT PUBLICATIONS RESEARCH SERVICE WASHINGTON D C
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| Contents: Changes in todynamics of patients suffering from myocardial infraction in the climatic conditions of Ashkhabad, by S. A. Radyukova Clinico-anatomical characteristics of congenital developmental defects, by S. E. Gleiberman |
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| Aortic Thrombosis in Atherosclerosis - USSR |
20 SEP 1960 |
16 pages |
| Authors:
V. S. Smolenskiy; JOINT PUBLICATIONS RESEARCH SERVICE ARLINGTON VA
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