The quaternary nitrogen drugs present some problems when identifying them in a mixture of drugs or in tissues. This note describes a TLC (thin-layer chromatography) method by which microgram amounts of quaternary nitrogen drugs can be separated and tentatively identified in less than 30 min.
A fourth experiment was conducted as part of a series designed to test an hypothesis concerning drug enhancement of performance under task-induced stress. The drug conditions included chlordiazepoxide (25 mg.), d-amphetamine (11-17 mg.), placebo and no drug. Other independent variables were latency and input pacing rate. Chlordiazepoxide had a slight tendency to impair performance at both levels of pacing. D-amphetamine confirmed the previously-observed trend to enhance performance at moderate levels ...
Six male subjects performed a paced serial adding task (PSAT) daily, weekends excepted, for four weeks. Each subject always performed the task at three different pacing rates, with two different stimulus durations at each rate. Every morning, before testing, subjects took capsules which contained either a placebo, or amphetamine, chlorpromazine, meprobamate, or secobarbital. Performance was always better the slower the pacing rate and the longer the stimulus duration, regardless of ...
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