The primary accomplishments included the synthesis and study of derivatives of the 3-isopropylcyclobutane system, which provided successful ingress to means for defining conformational consequences of nonplanarity. Cis and trans 3-isopropylcyclobutanecarboxylate esters were equilibrated: cis and trans 3-isopropylcyclobutylamines and cis and trans 3-isopropylcyclobutanols were synthesized and configurational assignments made by reference to equilibrated ester. NMR spectra of the above series of compounds, and the equilibration data, strongly support the conclusion that ...
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(CYCLOBUTANES
