A total of 34 selected compounds, including natural products, some compounds known to be efficacious against other diseases, cholesterol lowering drugs currently in use in human beings, and pro drugs of the pentamidine type were studied in hamsters at various dosage levels, via various routes and treatment schedules for antileishmanial efficacy against Leishmania (leishmania) donovani. One of the same compounds (Baycol) was studied for efficacy against ...
A total of 16 selected compounds which included some natural products as well as drugs known to be efficacious against other diseases were studied at various dosage levels and via various routes of administration in hamsters for antileishmanial efficacy against visceral leishmaniasis (Leishmania Leishmania donovani) and three of the same compounds were studied for activity against cutaneous leishmaniasis (Leishmania Vianni panamensis). None of these were efficacious against either leishmania but ...
During this contract, a total of 205 selected compounds were studied for efficacy against Leishmania Leishmania donovani infections in hamsters. Forty-four of these compounds were active as indicated by 50 percent or greater parasite suppression. Glucantime Indices ranged from 1,418 to 0.351. Among these active compounds were 8-aminoquinolines (which are the most efficacious), phenanthrene methanols, dibenzopyrroles, disulfides, aminothiols, and C- nucleosides. When Glucantime, Pentostam or Amphotericin B were given in ...
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*ANTILEISHMANIAL DRUGS
