| VeriML: A Dependently-Typed, User-Extensible and Language-Centric Approach to Proof Assistants |
Jan 2013 |
270 pages |
| Authors:
Antonios M Stampoulis; YALE UNIV NEW HAVEN CT
|
 | Software certification is a promising approach to producing programs which are virtually free of bugs. It requires the construction of a formal proof which establishes that the code in question will behave according to its specification - a higher-level description of its functionality. The construction of such formal proofs is carried out in tools called proof assistants. Advances in the current state-of-the-art proof assistants have enabled the certification of a ... |
|
| Biomarkers for Autism and for Gastrointestinal and Sleep Problems in Autism |
Oct 2012 |
4 pages |
| Authors:
George M Anderson; YALE UNIV NEW HAVEN CT
|
| The objective of the proposed research is to compare the production of melatonin by young children with autism (N=45) to typically developing children (N=45). Specifically, we will see if the nighttime excretion rate of melatonin sulfate is markedly lower in the children with autism, whether there is a subgroup of children with autism having very low excretion; whether low nighttime excretion of melatonin sulfate is associated with sleep problems; and ... |
|
| Intelligent Distributed Control |
10 Aug 2012 |
6 pages |
| Authors:
A S Morse; YALE UNIV NEW HAVEN CT
|
| Here is a listing some of what this project has accomplished. We ve given a probabilistic explanation of why a previously proposed accelerated gossip algorithm works. We ve resolved the problem of automatically localizing a mobile autonomous agent using range-only measurements. We invented new tools for analyzing convergence rates for consensus and gossiping algorithms. We derived a complete solution to the problem of controlling a directed formation of triangular shape. ... |
|
| Understanding the Etiology of Tuberous Sclerosis Complex |
Jul 2012 |
56 pages |
| Authors:
Angelique Bordey; YALE UNIV NEW HAVEN CT
|
| Tuberous Sclerosis Complex (TSC) is a genetic multisystem disorder characterized by severe neurological symptoms (e.g. seizures), which are the most significant causes of disability and morbidity. Presently, there are no known cures for TSC and the etiology of the disease is not well understood, perhaps due to the lack of model system to study this disorder. In TSC patients, mutations in Tsc1 or Tsc2, result in the formation of lesions. ... |
|
| Prazosin for Treatment of Patients With PTSD and Comorbid Alcohol Dependence |
Jul 2012 |
8 pages |
| Authors:
Ismene Petrakis; Elizabeth Ralevski; YALE UNIV NEW HAVEN CT
|
| Background: There is a high rate of comorbidity with alcohol dependence (AD) and post traumatic stress disorder (PTSD). The rates of PTSD among individuals with AD are at least twice as high as those in the general population. In addition, alcohol dependence is the most common comorbid condition in men with PTSD. Despite this, little is known about hot to best treat individuals with comorbid AD and PTSD. The use ... |
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| Polyester Culture: The U.S. Army's Aversion to Broadening Assignments |
18 Apr 2012 |
54 pages |
| Authors:
Thomas D Boccardi; YALE UNIV NEW HAVEN CT
|
| This study examines the puzzle introduced by Secretary Gates in his speech at West Point: how the Army can adapt its practices and culture break-up the institutional concrete, its bureaucratic rigidity in its assignments and promotion processes? The Army has proven its ability to adapt and innovate in many areas, yet it has not done so with its personnel practices. This study seeks to determine why career development practices for ... |
|
| Biomarkers for Autism And For Gastrointestinal And Sleep Problems In Autism |
Oct 2011 |
5 pages |
| Authors:
George M Anderson; YALE UNIV NEW HAVEN CT
|
| No data analyses were planned or have been performed to date and thus no findings are reported. |
|
| Mental Health and Resilience: Soldiers' Perceptions about Psychotherapy, Medication, and Barriers to Care in the United States Military |
Oct 2011 |
20 pages |
| Authors:
Steven Southwick; YALE UNIV NEW HAVEN CT
|
| Research has reported perceived barriers to care in military populations, but there have not been any studies to date that demonstrate the degree to which subjective barriers translate into lack of utilization. Moreover, studies of mental health service utilization have not examined patient beliefs and perceptions, instead focusing on characteristics such as race, gender, and sociodemographic variables. To our knowledge there have not been any systematic investigations into what soldiers ... |
|
| Using Propranolol to Block Memory Reconsolidation in Female Veterans with PTSD |
Oct 2011 |
5 pages |
| Authors:
Deane Aikins; YALE UNIV NEW HAVEN CT
|
| One of the hallmark features of Posttraumatic Stress Disorder (PTSD) is a marked increased in physical arousal (i.e., increased heart rate, muscle tension, etc.) when recalling a trauma-related memory. In this manner, a treatment that decreased the hyper-arousal of a traumatic memory to less-impairing levels may do well in allowing an individual with PTSD to return to his or her daily life. However, there is an imbalance at the heart ... |
|
| Understanding the Global Distribution of Monsoon Depressions |
30 Sep 2011 |
9 pages |
| Authors:
William R Boos; YALE UNIV NEW HAVEN CT
|
| This project aims to improve the understanding of cyclonic storms called monsoon depressions, which play an important role in the meteorology of the tropical and subtropical eastern hemisphere and serve as precursors for typhoons in the Indian and Western Pacific Oceans. The work undertaken here serves as part of a broader effort to better understand and predict tropical cyclogenesis and the variability of monsoon climates in Asia, Australia, Africa, and ... |
|
| Understanding the Etiology of Tuberous Sclerosis Complex |
JUL 2011 |
29 pages |
| Authors:
Angelique Bordey; YALE UNIV NEW HAVEN CT
|
| Tuberous Sclerosis Complex (TSC) is a genetic multisystem disorder characterized by severe neurological symptoms (e.g., seizures), which are the most significant causes of disability and morbidity. Presently, there are no known cures for TSC and the etiology of the disease is not well understood, perhaps due to the lack of a model system to study the disorder. In TSC patients, mutations in one of two tumor suppressor genes, Tsc1 or ... |
|
| Prazosin for Treatment of Patients with PTSD and Comorbid Alcohol Dependence |
Jul 2011 |
6 pages |
| Authors:
Ismene Petrakis; YALE UNIV NEW HAVEN CT
|
| There is a high rate of comorbidity with alcohol dependence (AD) and post traumatic stress disorder (PTSD). The rates of PTSD among individuals with AD are at least twice as high as those in the general population. In addition, alcohol dependence is the most common comorbid in men with PTSD. Despite this, little is known about how to best treat individuals with comorbid AD and PTSD. The use of an ... |
|
| A New Therapeutic Strategy for Autosomal Dominant Polycystic Kidney Disease: Activation of AMP Kinase by Metformin |
Jul 2011 |
23 pages |
| Authors:
Michael J Caplan; YALE UNIV NEW HAVEN CT
|
| Autosomal dominant polycystic kidney disease is a common inherited disorder. Patients are born with normal kidneys but, over the course of decades, they develop large fluid filled cysts that damage the normal kidney tissue. The damage caused by these cysts can lead ultimately to kidney failure, necessitating kidney transplantation or dialysis. There are currently no approved medications for this condition. Recent research reveals that the formation of cysts is due ... |
|
| Using Propranolol to Block Memory Reconsolidation in Female Veterans with PTSD |
Oct 2010 |
5 pages |
| Authors:
Deane Aikins; YALE UNIV NEW HAVEN CT
|
| One of the hallmark features of Posttraumatic Stress Disorder (PTSD) is a marked increased in physical arousal (i.e., increased heart rate, muscle tension, etc.) when recalling a trauma-related memory. In this manner, a treatment that decreased the hyper-arousal of a traumatic memory to less-impairing levels may do well in allowing an individual with PTSD to return to his or her daily life. However, there is an imbalance at the heart ... |
|
| The Presence of Nonnuclear Estrogen Receptor-alpha in Breast Cancer and Its Prognostic/Predictive Value |
OCT 2010 |
52 pages |
| Authors:
Allison Welsh; YALE UNIV NEW HAVEN CT
|
| My research has shown that while we can detect non-nuclear ER reproducibly in a small number of breast cancer specimens, its low incidence implies a minimal prognostic or predictive value, and often poor antibody validation is a confounding factor. While negative, we feel these results are important to share with the scientific and clinical world. These roadblocks have also provided an impetus to develop a quantified and standardized assay to ... |
|
| Met (HGF Receptor) in Breast Cancer |
Sep 2010 |
25 pages |
| Authors:
Jennifer Bordeaux; YALE UNIV NEW HAVEN CT
|
| The hepatocyte growth factor (HGF)/Met signaling pathway has been shown to be important for stimulating cell proliferation, motility, invasion and metastasis. Recent work from our lab has identified a 60 kDa fragment from the carboxy-terminal domain of Met that localizes to the nucleus. Preliminary data from our also indicates that Met is translocated to the nucleus during in vitro wound healing of epithelial sheets of cells, but appears to be ... |
|
| Prazosin for Treatment With PTSD And Comorbid Alcohol Dependence |
01 JUL 2010 |
4 pages |
| Authors:
Ismene Petrakis; YALE UNIV NEW HAVEN CT
|
| There is a high rate of comorbidity with alcohol dependence (AD) and post traumatic stress disorder (PTSD). The rates of PTSD among individuals with AD are at least twice as high as those in the general population. In addition, alcohol dependence is the most common comorbid condition in men with PTSD. Despite this, little is known about how to best treat individuals with comorbid AD and PTSD. The use of ... |
|
| The Presence of Nonnuclear Estrogen Receptor-alpha in Breast Cancer and Its Prognostic/Predictive Value |
Oct 2009 |
23 pages |
| Authors:
Allison Welsh; YALE UNIV NEW HAVEN CT
|
| There is rising biologic concern in breast cancer that the current standard purely measures nuclear ER expression, despite the fact that it is now widely accepted amongst scientists that ER signals non-genomically. The ultimate goal of this research is to develop one (or a variety of) assay(s) that can measure this non-genomic signaling and provide superior value in predicting response to Tamoxifen. My results to date have allowed me to ... |
|
| Molecular Basis for BRCA2-mediated DNA Repair and Breast Tumor Suppression |
Oct 2009 |
19 pages |
| Authors:
Julia Etchin; YALE UNIV NEW HAVEN CT
|
| In eukaryotes, homologous recombination and the homology-directed repair of DNA double-strand breaks are mediated by the RAD51 recombinase. In catalyzing recombination reactions, RAD51 must first form a right-handed helical filament, termed the presynaptic filament, on single-stranded DNA. Emerging evidence indicates that BRCA2 acts a recombination mediator by promoting the assembly of the RAD51 presynaptic filament. BRCA2 binds DNA and associates with RAD51. Our laboratory has established biochemical systems to examine ... |
|
| Using Propranolol to Block Memory Reconsolidation in Female Veterans with PTSD |
Oct 2009 |
5 pages |
| Authors:
Deane Aikins; YALE UNIV NEW HAVEN CT
|
| In the current study, we will be investigating a method for blocking memory reconsolidation in three groups of female Veterans of either Operation Iraqi Freedom or Operation Enduring Freedom (OIF/OEF) with PTSD. During the first year of the 3 year project, institutional review approvals were obtained from Yale University School of Medicine, VA Connecticut Healthcare System, West Haven Campus, and U.S. Army Medical Research and Materiel Command Office of Research ... |
|
| Genomic Instability and Breast Cancer |
Oct 2009 |
124 pages |
| Authors:
Junjie Chen; YALE UNIV NEW HAVEN CT
|
| We are investigating the regulation of genomic stability and how the disruption of such regulation contributes to breast cancer development. We have performed in-depth studies of BRCA1 and the DNA damage response, which allow us to propose a new model of DNA damage signaling pathways and how it functions to ensure genomic stability in response to DNA damage. In addition, we are continuing our purification of protein complexes for the ... |
|
| Microtubule-Associated Protein Expression and Predicting Taxane Response |
Oct 2009 |
30 pages |
| Authors:
Maria T Baquero; YALE UNIV NEW HAVEN CT
|
| Taxanes are microtubule targeting agents (MTAs) and potent cytotoxic molecules recognized as highly effective chemotherapeutic agents. In large randomized clinical trials, taxane-based chemotherapies provided benefits in overall and disease-free survival, but they are accompanied by significant adverse effects. Thus the clinical utility of taxane therapy would be enhanced if there were companion diagnostic tests so that only the taxane-sensitive patients (about half of breast cancers) could be treated with this ... |
|
| Mental Health and Resilience: Soldiers' Perceptions about Psychotherapy, Medication, and Barriers to Care in the United States Military |
Oct 2009 |
6 pages |
| Authors:
Steven M Southwick; Deane Atkins; Alison Rivers; YALE UNIV NEW HAVEN CT
|
| This study aims to examine beliefs about mental health care, perceived barriers to care and stigma, mental health resilience, and healthcare utilization in soldiers returning from Iraq and Afghanistan. This report covers the first year of the grant (September 15, 2008-September 14, 2009). Research activities have not yet begun as internal review board approval at all appropriate institutional sites is still being sought. Approval has been received with the Yale ... |
|
| Met (HGF Receptor) in Breast Cancer |
Sep 2009 |
18 pages |
| Authors:
Jennifer Bordeaux; YALE UNIV NEW HAVEN CT
|
| The hepatocyte growth factor (HGF)/Met signaling pathway has been shown to be important for stimulating cell proliferation, motility, invasion and metastasis. Recent work from our lab has identified a 60 kDa fragment from the carboxy-terminal domain of Met that localizes to the nucleus. Preliminary data from our also indicates that Met is translocated to the nucleus during in vitro wound healing of epithelial sheets of cells. Because several pharmaceutical companies ... |
|
| Trapping and Cooling of Polar Molecules |
06 Jun 2009 |
16 pages |
| Authors:
D DeMille; YALE UNIV NEW HAVEN CT
|
| This project centered on the development of new methods to trap, cool, and detect polar molecules, with potential application across a broad range of subfields. Progress was made on several inter-related fronts. A new, simple and general source for slow and cold molecular beams was developed. This source was demonstrated to work, with several molecular species, in two regimes: one with low velocity but also low flux, and another with ... |
|
| Microtubule-Associated Protein Expression and Predicting Taxane Response |
Oct-2008 |
29 pages |
| Authors:
Maria T Baquero; YALE UNIV NEW HAVEN CT
|
| We hypothesized that in addition to its predictive value, the microtubule-associated marker tau (MAP-tau) may also function as a prognostic biomarker. The dual functionality of MAP-tau may translate into increased tumor molecular screening information for patients with breast cancer resulting in better treatment options. Previous results of this work indicate that MAP-tau functions as a prognostic marker in early stage breast cancer when examined using tissue microarrays and automated quantitative ... |
|
| Molecular Basis for BRCA2-mediated DNA Repair and Breast Tumor Suppression |
Oct 2008 |
12 pages |
| Authors:
Julie Etchin; YALE UNIV NEW HAVEN CT
|
| In eukaryotes, homologous recombination and the homology-directed repair of DNA double-strand breaks are mediated by the RAD51 recombinase. In catalyzing recombination reactions, RAD51 must first form a right-handed helical filament, termed the presynaptic filament, on single-stranded DNA. Emerging evidence indicates that BRCA2 acts a recombination mediator by promoting the assembly of the RAD51 presynaptic filament. BRCA2 binds DNA and associates with RAD51. Our laboratory has established biochemical systems to examine ... |
|
| Does Increased Expression of the Plasma Membrane Calcium-ATPase Isoform 2 Confer Resistance to Apoptosis on Breast Cancer Cells? |
Sep 2008 |
12 pages |
| Authors:
Joshua N VanHouten; YALE UNIV NEW HAVEN CT
|
| The plasma membrane calcium ATPase isoform 2 (PMCA2) is highly expressed on the apical membrane of mammary epithelial cells during lactation, and is the predominant pump responsible for calcium transport into milk. The lack of PMCA2 causes a low epithelial content in pregnant deafwaddler (dfw 2J) mouse mammary glands due to widespread apoptosis. The apoptosis is likely a result of elevated cytosolic calcium levels due an imbalance of calcium influx ... |
|
| The Structural Basis of Pathogen Recognition by TLR Receptors of the Innate Immune System |
Aug-2008 |
21 pages |
| Authors:
Yorgo Modis; YALE UNIV NEW HAVEN CT
|
| The innate immune system is the first line of defense against invading pathogens. The overall goal of this project is to understand how a key family of innate immune receptors, the Toll-like receptors (TLRs), recognize their microbial ligands, and how this recognition is translated into an immune response. This report covers an initial one-year contract in a three-year project. In our first year, we developed methods to purify milligram quantities ... |
|
| Analysis and Design of Highly Resilient Wireless and Sensor Networks |
23-Jun-2008 |
8 pages |
| Authors:
Edmund Yeh; YALE UNIV NEW HAVEN CT
|
| The main goal of this project is to establish a fundamental analytical and design framework for highly resilient wireless and sensor networks based on the study of the qualitative and quantitative properties of the largest connected component. Building on our recent promising results in the field of percolation, we propose to design network structures and algorithms to greatly enhance the resilience of high-performance wireless and sensor networks within challenging and ... |
|
| Quantitative in Situ Assessment of the Somatostatin Receptor in Breast Cancer to Assess Response to Targeted Therapy with 111-in-Pentetreotide. Addendum |
01-May-2008 |
41 pages |
| Authors:
David Rimm; Gina G Chung; YALE UNIV NEW HAVEN CT
|
| Somatostatin (SST) is a peptide hormone implicated in the growth and progression of cancers and SSTR2 is the predominant receptor subtype expressed in breast cancer. We hope to study the pattern of expression and clinical significance of SSTR2 levels in breast cancer. We have developed an algorithm called AQUA that can assess protein expression on tissue microarrays (TMA) based on molecular co-localization techniques. Our results show that SSTR2 is localized ... |
|
| Development of a Test Battery to Assess Mental Flexibility Based on Sternberg's Theory of Successful Intelligence |
JAN 2008 |
110 pages |
| Authors:
Cynthia T. Matthew; Jens F. Beckman; Robert J. Sternberg; YALE UNIV NEW HAVEN CT
|
| A test battery to assess mental flexibility was developed based on Sternberg's theory successful intelligence (1985). New mental flexibility assessment instruments were developed and underwent formative and summative evaluation. The newly developed mental flexibility tests showed adequate reliability, and preliminary evidence of construct- and criterion-related validity. One mental flexibility factor explained 70% of variance in the test battery and was differentiated from the latent factor underlying divergent and convergent measures ... |
|
| Genomic Instability and Breast Cancer |
OCT 2007 |
87 pages |
| Authors:
Junjie Chen; YALE UNIV NEW HAVEN CT
|
| Genomic instability is one of the key initiating events that lead to breast cancer development. We would like to gain further insights into the regulation of genomic stability and how the disruption of this regulation contributes to tumorigenesis. In the past year, we have identified several new components in the DNA damage pathway that act upstream of BRCA1. We have also discovered a novel link between aging and breast cancer ... |
|
| Microtubule-Associated Protein Expression and Predicting Taxane Response |
OCT 2007 |
81 pages |
| Authors:
Maria T. Baquero; YALE UNIV NEW HAVEN CT
|
| We hypothesized that in addition to its predictive value, the microtubule-associated marker tau (MAP-tau) may also function as a prognostic biomarker. The dual functionality of MAP-tau may translate into increased tumor molecular screening information for patients with breast cancer resulting in better treatment options. The results of this work indicate that MAP-tau functions as a prognostic marker for paclitaxel sensitivity when examined using automated quantitative analysis (AQUA) and tissue arrays ... |
|
| Molecular Basis for BRCA2-mediated DNA Repair and Breast Tumor Suppression |
OCT 2007 |
8 pages |
| Authors:
Julia Etchin; YALE UNIV NEW HAVEN CT
|
| In eukaryotes, homologous recombination and the homology-directed repair of DNA double-strand breaks are mediated by the RAD51 recombinase. In catalyzing recombination reactions, RAD51 must first form a right-handed helical filament, termed the presynaptic filament, on single-stranded DNA. Emerging evidence indicates that BRCA2 acts a recombination mediator by promoting the assembly of the RAD51 presynaptic filament. BRCA2 binds DNA and associates with RAD51. Our laboratory has established biochemical systems to examine ... |
|
| Quantitative in situ Assessment of the Somatostatin Receptor in Breast Cancer to Assess Response to Targeted Therapy with 111-in-Pentetreotide |
01 MAY 2007 |
11 pages |
| Authors:
Gina G. Chung; David Rimm; YALE UNIV NEW HAVEN CT
|
| Somatostatin (SST) is a peptide hormone implicated in the growth and progression of cancers and SSTR2 is the predominant receptor subtype expressed in breast cancer. We hope to study the pattern of expression and clinical significance of SSTR2 levels in breast cancer. We have developed an algorithm called AQUA that can assess protein expression on tissue microarrays (TMA) based on molecular co-localization techniques. Our results show that SSTR2 is localized ... |
|
| Met Nuclear Localization and Signaling in Breast Cancer |
01 MAY 2007 |
23 pages |
| Authors:
Sharon P. Moulis; YALE UNIV NEW HAVEN CT
|
| To explore the effects of exercise training on tumor vascularity and response to neoadjuvant therapy in operable breast cancer in a phase I-II randomized design. Method: Using a two-armed prospecbve randomized design potential participants will be identified and screened for eligibility via medical record review of patients scheduled for their primary neoadjuvant chemotherapy treatment consultation at DUMC. Following the successful completion of all baseline assessments participants will be randomly assigned ... |
|
| Probabilistic Analysis of Onion Routing in a Black-box Model |
2007 |
11 pages |
| Authors:
Joan Feigenbaum; Aaron Johnson; Paul Syverson; YALE UNIV NEW HAVEN CT
|
| We perform a probabilistic analysis of onion routing. The analysis is presented in a black-box model of anonymous communication that abstracts the essential properties of onion routing in the presence of an active adversary that controls a portion of the network and knows all a priori distributions on user choices of destination. Our results quantify how much the adversary can gain in identifying users by exploiting knowledge of their probabilistic ... |
|
| Role of Rad51-Mediated Interactions in Recombination |
AUG 2006 |
13 pages |
| Authors:
Steven Raynard; YALE UNIV NEW HAVEN CT
|
| Mutations in the BRCA2 gene are linked to familial and sporadic breast cancer, yet the molecular function of BRCA2 protein remains largely obscure. BRCA2 protein physically interacts with the Rad51 recombinase, a member of the RAD52 epistasis group of proteins that mediate homologous recombination (HR), a major mechanism that repairs chromosomes damaged by ionizing radiation and genotoxic agents. Accordingly, BRCA2 deficient cell lines exhibit impaired HR and sensitivity to genotoxic ... |
|
| Interdisciplinary Research Training in Breast Cancer |
JUL 2006 |
13 pages |
| Authors:
Ruth McCorkle; YALE UNIV NEW HAVEN CT
|
| The purpose of this predoctoral and postdoctoral training program is to prepare clinical researchers who will impact the care of women with breast cancer. Under the two program directors, Drs. Ruth McCorkle and Michael DiGiovanna, the program has completed its fifth year. Over the entire training program, six predoctoral and five postdoctoral trainees have been funded. Breast cancer content has been included in the curriculum of the doctoral program. The ... |
|
| Decentralized Control and Decentralized Adaptive Control |
JUN 2006 |
31 pages |
| Authors:
Kumpati S. Narenda; YALE UNIV NEW HAVEN CT
|
| As systems become complex with many interconnected subsystems, decentralized control becomes essential. When certain parameters of the system are unknown, and/or when subsystems are not aware of the signals from other subsystems that affect their behavior, we need decentralized adaptive control. The report deals with questions that arise while analyzing the stability and performance of decentralized adaptive control systems. The project produced three specific results: 1. Interconnected dynamical systems can ... |
|
| Quantitative in Situ Assessment of the Somatostatin Receptor in Breast Cancer to Assess Response to Targeted Therapy With 111-in-Penetreotide |
MAY 2006 |
15 pages |
| Authors:
Gina G. Chung; John Murren; David Rimm; YALE UNIV NEW HAVEN CT
|
| Somatostatin (SST) is a peptide hormone implicated in the growth and progression of cancers and SSTR2 is the predominant receptor subtype expressed in breast cancer. We hope to study the pattern of expression and clinical significance of SSTR2 levels in breast cancer. To this end, we have developed an algorithm called AQUA that can assess protein expression on tissue microarrays (TMA) based on molecular co-localization techniques. Our results show that ... |
|
| Met Nuclear Localization and Signaling in Breast Cancer |
MAY 2006 |
18 pages |
| Authors:
Sharon P. Moulis; YALE UNIV NEW HAVEN CT
|
| Some breast cancer cases in our previous immunohistochemical studies show Met expression in the nucleus. Given nuclear localization of other receptor tyrosine kinases, we proceeded to investigate Met. Nuclear Met is seen in numerous cell lines and in germinal regions of many tissues using 4 unique antibodies. Cell fractionation reveals a 60kDa band recognized by C-terminal Met antibodies that is present independent of HGF treatment. GFP fusion proteins of the ... |
|
| Integrated Sensing and Processing Digital Synapses |
03 JAN 2006 |
11 pages |
| Authors:
Ronald R. Coifman; Vladimir Rokhlin; Steven Zucker; Andreas Coppi; Frank Geschwind; YALE UNIV NEW HAVEN CT
|
| Over the duration of phase I of the ISP (01-Aug-2002 to 31-Jul-2005), we built two digitally controlled sensing systems and assembled a tabletop environment for testing and demonstration of massive data acquisition and handling. Components of the system are discussed. A variety of analytical tools for achieving the diffusion and low-dimensional paramaterizations have been developed. Examples given of results during the research in phase 1, and details of the research, ... |
|
| Student Support: Spin Decoherence Measurements for Solid State Qubits |
OCT 2005 |
15 pages |
| Authors:
Sean E. Barrett; YALE UNIV NEW HAVEN CT
|
| This project supported Mr. Dale Li with a Quantum Computation Graduate Research (QuaCGR) Fellowship. Dale played a key role as the most senior student in our group, during our work on the research grant #DAAD19-01-1-0507 Spin Decoherence Measurements for Solid State Qubits . That project's initial goal was to measure decoherence times for solid-state qubits. We unexpectedly found a clear discrepancy between two different standard measurements of T2 . Specifically, ... |
|
| Experiments on a Quantum Gate Based on Charge-Current Superconducting Qubit |
31 AUG 2005 |
15 pages |
| Authors:
Michel H. Devoret; YALE UNIV NEW HAVEN CT
|
| During this grant, we have invented, designed and successfully operated a new type of readout for charge-phase superconducting qubits. This new readout is based on the bifurcation of an RF-driven Josephson junction inserted in the loop of a split Cooper pair box. When the amplitude of the RF drive is in the vicinity of the bifurcation points a small change in the effective critical current of the junction is amplified ... |
|
| Graduate Student Support for Quantum Computing With Superconducting Charge States |
31 AUG 2005 |
49 pages |
| Authors:
Robert J. Schoelkopf; YALE UNIV NEW HAVEN CT
|
| This project supplies support for an additional graduate student, Mr. David Schuster, on experimental investigations on quantum coherence, entanglement, and quantum computation in solid-state, electronic realization of quantum bits based on superconducting single-electron devices, namely the single Cooper-pair box. Mr. Schuster has developed a process for fabrication of Al/AlOx/Al tunnel qubits with integrated transmission line resonators, and used these devices for cavity-QED manipulations and readout of qubits. This work has ... |
|
| Role of Rad51-Mediated Interactions in Recombination |
AUG 2005 |
9 pages |
| Authors:
Steven Raynard; YALE UNIV NEW HAVEN CT
|
| Mutations in the BRCA2 gene are linked to familial and sporadic breast cancer, yet the molecular function of BRCA2 protein remains largely obscure. BRCA2 protein physically interacts with the Rad51 recombinase, a member of the RAD52 epistasis group of proteins that mediate homologous recombination (HR), a major mechanism that repairs chromosomes damaged by ionizing radiation and genotoxic agents. Accordingly, BRCA2-deficient cell lines exhibit impaired HR and sensitivity to genotoxic agents. ... |
|
| Mechanisms of Graft-vs.-Leukemia Against a Novel Murine Model of Chronic Myelogenous Leukemia |
JUL 2005 |
8 pages |
| Authors:
Warren D. Shlomchik; YALE UNIV NEW HAVEN CT
|
| Our objective is to understand the immunobiology underlying the differential sensitivity of chronic phase and blast crisis CML. Our data thus far support the hypothesis that GVL against mCP-CML can be mediated by redundant processes, and that impairment of an individual pathway is insufficient to prevent GVL. We hypothesize that GVL against BC-CML is less forgiving than that against CP-CML, and that multiple effector pathways must act in concert for ... |
|
| Interdisciplinary Research Training in Breast Cancer |
JUL 2005 |
31 pages |
| Authors:
Ruth McCorkle; YALE UNIV NEW HAVEN CT
|
| The purpose of this predoctoral and postdoctoral training program is to prepare clinical researchers who will impact the care of women with breast cancer. Under the two program directors, Drs. Ruth McCorkle and Michael DiGiovanna, the program has completed its fifth year. Over the entire training program, six predoctoral and five postdoctoral trainees have been funded. Breast cancer content has been included in the curriculum of the doctoral program. The ... |
|
Reports by Corporate Author
