WRIGHT STATE UNIV DAYTON OH DEPT OF PHARMACOLOGY AND TOXICOLOGYY
Click on the titles below to find US government-authored or -collected reports written by WRIGHT STATE UNIV DAYTON OH DEPT OF PHARMACOLOGY AND TOXICOLOGYY
Dermal exposure to JP-8 has been shown to cause skin irritation in humans and laboratory animals. We have previously investigated the early responses of mammalian skin to liquid JP-8 contact. We have developed a novel in vivo rat model for the investigation of skin irritation, which maintains the interactions and crosstalk of the wide variety of cells in the epidermis and dermis. We have used this model to investigate early ...
Organic solvents like xylene are recognized as skin irritants after dermal exposure. The molecular responses to organic solvents that result in acute irritation are not understood. In the present study, we compared and quantified the molecular responses of rat and guinea pigs skin to xylene irritation, since these species differ in their response to other chemicals. We also determined which animal model was more appropriate for predicting xylene-induced skin irritation. ...
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