| The Effective Behavior of Heterogeneous Ferromagnetic Materials |
31 Jan 2010 |
3 pages |
| Authors:
WASHINGTON UNIV SEATTLE
|
 | In the project, we have studied a variety of heterogeneous ferromagnetic materials, including ferromagnetic shape memory alloys, multiferroic materials, and ferromagnetic composites. The main achievements have been summarized as following: 1. A constrained theory of magnetoelastic materials has been developed to study the effective behavior of single-crystalline and polycrystalline ferromagnetic shape memory alloys (FSMA) based on nonlinear homogenization theory and variational principle. The actuation strain induced by domain switching under ... |
|
| Identification of Tumor Rejection Antigens for Breast Cancer Using a Mouse Tumor Rejection Model |
May 2009 |
31 pages |
| Authors:
Mary L Disis; WASHINGTON UNIV SEATTLE
|
| Pre-menopausal patients whose breast cancers are, in general, estrogen receptor (ER) negative and biologically more aggressive, are particularly in need of novel therapeutic interventions. A breast cancer vaccine to prevent relapse after conventional treatment would be of enormous clinical value. Several cancer vaccine studies have demonstrated that breast cancer patients can develop tumor antigen specific immune responses after a vaccine is given. Most of these approaches target a single immunogenic ... |
|
| A Partnership for Modeling the Marine Environment of Puget Sound, Washington |
30-Mar-2009 |
11 pages |
| Authors:
Jan Newton; Skip Albertson; Frederick R Stahr; P F Wang; Robert K Johnston; William Winn; Mark Warner; Allan Devol; Mitsuhiro Kawase; Randy Shuman; Miles Logsdon; Bruce Nairn; WASHINGTON UNIV SEATTLE
|
| In 2002 National Oceanographic Partnership Program funded a partnership of a university, federal, state and local government agencies, and a private non-profit corporation who share a common interest and concern about a body of water -- Puget Sound, Washington. Designated as the Puget Sound Marine Environmental Modeling (PSMEM) partnership, the objectives of the partnership were to conduct scientific research aimed at developing fundamental understanding of the Sound's working, as well ... |
|
| Molecular Profiling of Prostate Cancer Specimens Using Multicolor Quantum Dots |
Feb-2009 |
14 pages |
| Authors:
Xiaohu Gao; WASHINGTON UNIV SEATTLE
|
| Each person's cancer is as unique as his or her fingerprint, which explains unpredictable responses to therapies and poses new biotechnology challenges for tumor characterization on the molecular level. For these reasons, it is of pivotal importance to develop novel molecular profiling methodologies for diagnosis, prognosis and individually tailored therapeutics of patients based on the biology of their tumors. We proposed to develop oligonucleotide tagged quantum dots and antibodies for ... |
|
| Hierarchical Integrated Communication and Control |
Jan-2009 |
17 pages |
| Authors:
Kristi A Morgansen; Tara Javidi; WASHINGTON UNIV SEATTLE
|
| A fundamental challenge in designing networked control systems is that communication and control are not. in general, decoupled from each other. In order to address this challenge, the methods used in this project fundamentally integrated the tools, capabilities and constraints of both control theory and networking. The proposed solution enabled leveraging of existing seminal works in both fields. It also allowed for a cross-layer rethinking of the wireless networks for ... |
|
| Senescence-Induced Alterations in the Laminin Component of Prostate Epithelial Extracellular Matrix Regulate Progression of Prostate Cancer |
Jan-2009 |
28 pages |
| Authors:
Cynthia C Sprenger; Stephen Plymate; WASHINGTON UNIV SEATTLE
|
| The purpose of this work was to determine how changes in laminin chains associated with senescence affected prostate cancer progression. In order to determine the effects of alterations to the laminin component of the tumor microenvironment, I overexpressed the laminin alpha 4, beta 2, or alpha 4 and beta 2 chains in a human prostate cancer cell line. I demonstrated that these lines secreted the specific laminin chains and incorporated ... |
|
| Use of New Industrial Coatings for the U.S. Navy Waterfront Structures |
Dec-2008 |
24 pages |
| Authors:
Matthew Bedard; WASHINGTON UNIV SEATTLE
|
| The U.S. Navy has been utilizing epoxy polyamide and coal tar epoxy coatings to protect waterfront structures such as piers and wharfs for many years. However these particular coatings have become undesirable for use as their VOC levels exceed the newly instituted guidelines published by the EPA in 1999. Therefore the Navy has begun the process of researching other potential coatings which meet the current federal standards. Some of these ... |
|
| Phase II Study of a HER-2/neu (HER2) Intracellular Domain (ICD) Peptide-Based Vaccine Administered to Stage IIIB and IV HER2 Positive Breast Cancer Patients Receiving Trastuzumab Monotherapy |
01-May-2008 |
16 pages |
| Authors:
Mary L Disis; WASHINGTON UNIV SEATTLE
|
| The primary purpose of this grant is to determine the overall survival (OS) benefit in Stage IIIB and IV HER2 positive breast cancer patients vaccinated with a HER2 intracellular domain (ICD) peptide-based vaccine while receiving maintenance trastuzumab. Patients enrolled will be HER2 overexpressing stage IIIB and IV breast cancer patients who have been treated to a clinical complete response remission or have stable bone only disease and are within 6 ... |
|
| Identification of Tumor Rejection Antigens for Breast Cancer Using a Mouse Tumor Rejection Model |
01-May-2008 |
9 pages |
| Authors:
Mary L Disis; WASHINGTON UNIV SEATTLE
|
| Our goal in this proposal is to identify antigens that are associated with tumor rejection. Whereas this study would not be possible in humans, we have recently established a tumor rejection model by implanting the mouse tumors derived from neu-tg mice into the parental FVB/N mouse, who are identical in every way except were NOT engineered to develop breast cancer. In our model, none of the parental FVB/N mice develop ... |
|
| Molecular Profiling of Prostate Cancer Specimens Using Multicolor Quantum Dots |
01-Feb-2008 |
7 pages |
| Authors:
Xiaohu Gao; WASHINGTON UNIV SEATTLE
|
| Each person's cancer is as unique as his or her fingerprint, which explains unpredictable responses to therapies and poses new biotechnology challenges for tumor characterization on the molecular level. For these reasons, it is of pivotal importance to develop novel molecular profiling methodologies for diagnosis, prognosis and individually tailored therapeutics of patients based on the biology of their tumors. We proposed to develop oligonucleotide tagged quantum dots and antibodies for ... |
|
| Bio-Gyros: Tunable Compliant Gryscopic Sensors |
10 JAN 2008 |
7 pages |
| Authors:
Thomas Daniel; WASHINGTON UNIV SEATTLE
|
| We examined the motion encoding characteristics of gyroscopic sensors implicated in the flight control systems of insects. These included antennae of moths and the halteres of large craneflies, two structures that encode the Coriolis forces associated with body rotations during aerial maneuvers in insects. Importantly, no prior research program has explored how the structural dynamics of such gyroscopes interact with motions to provide tunable encoding characteristics. Through both neurobiological and ... |
|
| Full-Field Strain Behavior of Friction Stir-Welded Titanium Alloy |
01-Jan-2008 |
236 pages |
| Authors:
Trent A Greenwell; WASHINGTON UNIV SEATTLE
|
| Titanium is an abundant elemental metal with an exceptional strength-to-weight ratio. Due to properties of high strength, low weight, high heat tolerance, and exceptional corrosion resistance, titanium alloys are used extensively in a number of industries, such as power production, mineral extraction, biomedical, marine, chemical processing, and, of particular interest here, aerospace. The aerospace industry is the single largest user of titanium, particularly Ti-6Al-4V which is considered the workhorse titanium ... |
|
| Exploring the Local Milky Way: M Dwarfs as Tracers of Galactic Populations |
DEC 2007 |
13 pages |
| Authors:
John J. Bochanski; Jeffrey A. Munn; Suzanne L. Hawley; Andrew A. West; Kevin R. Covey; Donald P. Schneider; WASHINGTON UNIV SEATTLE
|
| We have assembled a spectroscopic sample of low-mass dwarfs observed as part of the Sloan Digital Sky Survey along one Galactic sight line, designed to investigate the observable properties of the thin and thick disks. This sample of ~7400 K and M stars also has measured ugriz photometry, proper motions, and radial velocities. We compute UVW space-motion distributions, and investigate their structure with respect to vertical distance from the Galactic ... |
|
| Stromal Mesenchyme Cell Genes in Prostate Cancer Development: Epigenetic Markers for Cancer and Potential Targets for Therapy |
DEC 2007 |
64 pages |
| Authors:
Young A. Goo; WASHINGTON UNIV SEATTLE
|
| Functional development of the prostate is governed by stromal induction and epithelial response. Given the importance of this communication it is possible that cancer could arise from a loss of this communication. We carried out comparative proteomic and transcriptome analyses to identify organ-specific stromal signaling factors from prostate and bladder stromal cells. Secreted proteins were identified by glycopeptide-capture followed by mass spectrometry. Protein quantification was done by PICA (Peptide Ion ... |
|
| CD4+ Th1 HER2-Specific T Cells as a Novel Treatment for HER2-Overexpressing Breast Cancer |
OCT 2007 |
14 pages |
| Authors:
Vy P. Lai; WASHINGTON UNIV SEATTLE
|
| During the last research period, we have made significant progress in the development of our mouse neu-reactive T cell lines. First, we have confirmed the key CD4+ neu peptides (p101 and p373) most effective at priming T cell responses. Of the peptide-specific T cell lines tested, only p101- and p373- T cells induced both peptide- and protein-specific responses. In preliminary studies involving adjuvants, GMCSF was highly effective for use with ... |
|
| The Impact of Breast Cancer on Adolescent Function |
01 JUL 2007 |
21 pages |
| Authors:
Frances M. Lewis; WASHINGTON UNIV SEATTLE
|
| The primary aim of this study was to test a theoretically derived predictive model of adolescent functioning to maternal breast cancer. Standardized questionnaires with well-established validity and reliability were used to measure 6 theoretical concepts in the model and were obtained from 222 study participants, including mothers recently diagnosed with breast cancer, their spouse, and their adolescent child. Results from tests of the theoretical model revealed that the adolescent was ... |
|
| Development of a 3-D Defocusing Liquid Crystal Particle Thermometry and Velocimetry (3DDLCPTV) System |
MAY 2007 |
144 pages |
| Authors:
David R. Schmitt; WASHINGTON UNIV SEATTLE
|
| One of the most intriguing and perplexing problems in fluid mechanics today, as it was 50 years ago, is that of turbulence. The behavior of a fluid in turbulent regions around an object consists of chaotic flow phenomena made of unsteady vortices on many scales that can critically affect the ability of that object to pass through the fluid. Indeed, turbulent convective heat and mass transfer is one of the ... |
|
| Identification of Tumor Rejection Antigens for Breast Cancer Using a Mouse Tumor Rejection Model |
MAY 2007 |
8 pages |
| Authors:
Mary L. Disis; WASHINGTON UNIV SEATTLE
|
| In the proposed study, we aim to identify tumor rejection antigens using mouse tumor rejection models. The study has three specific aims: (1) to determine the antigen repertoire induced by tumor rejection in FVB/N mice; (2) to identify the human homologues of the candidate rejection antigens and determine their immunogenicity; and, (3) to examine the in vivo tumor protection effect of vaccination with plasmids encoding tumor rejection antigens in neu-tg ... |
|
| Phase II Study of HER-2/neu Intracellular Domain Peptide-Based Vaccine Administered to Stage IV HER2 Positive Breast Cancer Patients Receiving Trastuzumab |
MAY 2007 |
11 pages |
| Authors:
Mary L. Disis; WASHINGTON UNIV SEATTLE
|
| The primary purpose of this grant is to determine the overall survival benefit in Stage IV HER2 positive breast cancer patients vaccinated with a HER2 ICD peptide-based vaccine while receiving maintenance trastuzumab. The scope of the work includes a Phase II single arm study of a HER2 ICD peptide based vaccine given concurrently with trastuzumab. Six patientshave been enrolled during the last reporting period. All adverse events reported for these ... |
|
| Clinical and Molecular Consequences of NF1 Microdeletion |
MAY 2007 |
43 pages |
| Authors:
Karen Stephens; WASHINGTON UNIV SEATTLE
|
| We have developed rapid and sensitive assays for the detection and mapping of both the common 1.4 Mb NF1 microdeletion and novel microdeletions; our subjects carrying microdeletions have contributed to diverse collaborations including development of a mouse model of plexiform neurofibroma tunorigenesis and the conservation of recombination hotspots. Our hypothesis that genome instability occurs during NF1-tumorigenesis continues to be supported by our findings. First, somatic instability leading to uniparental isodisomy ... |
|
| Stromal Mesenchyme Cell Genes in Prostate Cancer Development: Epigenetic Markers for Cancer and Potential Targets for Therapy |
DEC 2006 |
14 pages |
| Authors:
Young A. Goo; WASHINGTON UNIV SEATTLE
|
| Functional development of the prostate is governed by stromal induction and epithelial response. Stromal/epithelial signaling can be mediated through direct cell-cell contact and diffusible factors with their cell surface receptors. One approach to gain a molecular understanding of epithelial/stromal interaction is to identify the organ-specific stromal signaling factors. We proposed to do this through a comparative analysis between prostate stromal and bladder stromal cells. For the prostate/bladder transcriptome analysis, we ... |
|
| Superoxide Dismutase and Transcription Factor sox9 as Mediators of Tumor Suppression by mac25 (IGFBP-rp1) in Prostate Cancer Cells |
OCT 2006 |
52 pages |
| Authors:
Stephen R. Plymate; WASHINGTON UNIV SEATTLE
|
| The most significant conclusion that is going to be derived from the work on this proposal is the relationship of tumor cell contribution to the extra cellular environment and tumor growth. This was unexpected when we started this proposal and this work has not been completed. However, based on the findings generated in this DOD proposal Dr. Plymate has received a 5 yr NCI/NIH U54 Program Project to further develop ... |
|
| The Effects of Low to Moderate Intensity Aerobic Exercise on Fatigue in Breast Cancer Patients Following Clinical Treatment |
SEP 2006 |
111 pages |
| Authors:
Katherine L. Kemble; WASHINGTON UNIV SEATTLE
|
| To test the effects of a low to moderate intensity exercise on fatigue and overall QOL, both physiologically and psychologically in women who completed breast cancer treatment. Methods: Twenty-two women, ages 43-79, who had completed treatment for breast cancer, were randomly assigned to an exercise (n= 12) or control group (n = 10). The exercise group participated in a low-moderate intensity (30-50% heart rate reserve) aerobic exercise program 3 times ... |
|
| Evaluation of Roles of Interferon Gamma Regulated Genes in Inhibition of Androgen-Independent Prostate Cancer |
AUG 2006 |
87 pages |
| Authors:
Eva Corey; WASHINGTON UNIV SEATTLE
|
| CaP presents its greatest challenge to clinicians when it progresses to the hormone-independent state. Therapeutic methods which are effective regardless of androgen response, or even target androgen-independent CaP specifically, are of special medical and scientific interest. We have shown that estradiol (E2) can inhibit growth of hormone independent CaP in vivo. Among the genes up-regulated by E2 are IFN-regulated genes. The LuCaP 35V xenograft does not grow in vitro; for ... |
|
| Fiber Reinforced Polymer Strengthening in Construction Materials |
May-2006 |
53 pages |
| Authors:
Chad Lorenzana; WASHINGTON UNIV SEATTLE
|
| The United States has experienced an increase in the need for structural repair, especially in its public transportation infrastructure. At the same time, societal requirements to keep these structures open have placed pressure on facility engineers to perform rapid retrofits which entail minimal disruption to these systems. This need has brought the use of Fiber Reinforced Polymers (FRP) to the forefront, as its properties have proven to be invaluable in ... |
|
| Native Shellfish in Nearshore Ecosystems of Puget Sound |
APR 2006 |
27 pages |
| Authors:
Megan N. Dethier; Tom Mumford; Tom Leschine; Kurt Presh; Si Simenstad; Hugh Shipman; Doug Myers; Miles Logsdon; Randy Shuman; Curtis Tanner; Fred Goetz; WASHINGTON UNIV SEATTLE
|
| This document describes invertebrates found in Puget sound. Life history strategies, habitat requirements and anthropogenic influences are examined. Stock status and population trends of commercially important species is outlined. Land use and its impacts on the nearshore environment is discussed. |
|
| Cataclysmic Variables from Sloan Digital Sky Survey. V. The Fifth Year (2004) |
01 FEB 2006 |
12 pages |
| Authors:
Paula Szkody; Arne Henden; Gillian R. Knapp; Gary D. Schmidt; Todd K. Watson; Don Winget; J. C. Barentine; Ronald A. Downes; Eric H. Neilsen; Donald P. Schneider; WASHINGTON UNIV SEATTLE
|
| This paper identifies the cataclysmic variables that appear in spectra obtained in 2004 as part of the Sloan Digital Sky Survey. Spectra of 41 objects, including seven systems that were previously known (CC Cnc, DW Cnc, PQ Gem, AR UMa, AN UMa, RX J1131.3+4322, and UMa 6) and 34 new cataclysmic variables are presented. The positions and ugriz photometry of all 41 systems are given, as well as additional follow-up ... |
|
| The Effects of Low to Moderate Intensity Exercise on Fatigue in Breast Cancer Patients Following Clinical Treatment |
SEP 2005 |
17 pages |
| Authors:
KsKatherine L. Kemble; WASHINGTON UNIV SEATTLE
|
| Purpose: of this study was to test the effect of low to moderate intensity exercise on fatigue and physical functioning in women who have completed treatment for breast cancer. Sample: Twenty-two women, ages 43-79, who had completed treatment for breast cancer, were randomly assigned to an exercise (n= 12) or control group (n = 10). The exercise group participated in a low-moderate intensity (30-50% heart rate reserve) aerobic exercise program ... |
|
| Does the Phenotyping of Disseminated Prostate Cancer Cells in Blood and Bone Marrow Prior to Radical Prostatectomy Provide Prognostic Information: |
JUL 2005 |
17 pages |
| Authors:
Robert L. Vessella; WASHINGTON UNIV SEATTLE
|
| Nearly 20% of men who undergo a radical prostatectomy (RP) later relapse with bone metastases. The cellular events that are predictive of subsequent progressive disease remain unknown. We've focused attention on the detection of disseminated prostate cancer (CaP) cells in the blood and bone marrow. Our hypothesis is that these disseminated cells may provide critical insight regarding biomarkers of use in prognostication. We've developed enrichment and isolation techniques that allow ... |
|
| Superoxide Dismutase and Transcription Factor SOX9 as Mediators of Tumor Suppression by MAC25 (IGFBP-RP1) in Prostate Cancer Cells |
APR 2005 |
8 pages |
| Authors:
Stephen R. Plymate; WASHINGTON UNIV SEATTLE
|
| The hypothesis of this proposal is that: The mac25/lGFBP-rpl gene functions as a tumor suppressor for prostate epithelium by induction of additional genes regulating response to oxidative stress, senescence, and differentiation. One of these, SOD2, impairs tumor cell growth by detoxifying superoxides which may initiate transformation, or by interaction with growth promoting signal pathways via modulation of protein phosphorylation. Another, SOX9, induces a subset of genes required for differentiation of ... |
|
| Ever-Widening Horizons: Hemingway's War Literature, 1923 to 1940 |
09 MAR 2005 |
44 pages |
| Authors:
Byron J. Calhoun; WASHINGTON UNIV SEATTLE
|
| Ernest Hemingway has permeated the cultural consciousness so deeply that his fiction has become difficult to consider without preconceived bias. His name might evoke thoughts of a bullfighting aficionado, big-game hunter, war hero, war correspondent, or even misogynist; but one cannot judge his writing on such terms. It is frequently the erroneous merging of his literature and his carefully cultivated public machismo that leads to accusations that he celebrates violence ... |
|
| In Vitro Assessment of a Peptide Nucleic Acid (PNA) - Peptide Conjugate Labeled With an Auger-Emitting Radionuclide for Prostate Cell Killing |
FEB 2005 |
13 pages |
| Authors:
Scott D. Wilbur; WASHINGTON UNIV SEATTLE
|
| The ultimate goal of the research is to develop new treatment reagents for metastatic prostate cancer. Unfortunately, treatment of metastatic prostate cancer is problematic as the cells can become resistant to the therapy being used. Therefore, this exploratory research was directed at developing new therapy reagents that will not be affected by changes within cells. The therapy reagents use a radioactive material, Auger electron emitting radionuclides, to help solve the ... |
|
| Evaluation of Roles of Interferongamma Regulated Genes in Estradiol Inhibition of Androgen-Independent Prostate Cancer |
FEB 2005 |
8 pages |
| Authors:
Eva Corey; WASHINGTON UNIV SEATTLE
|
| Prostate cancer presents its greatest challenge to clinicians when it progresses to the hormone-independent state. Therapeutic methods which are effective regardless of androgen response, or even target androgen-independent CaP specifically, are of special medical and scientific interest. We have shown that estradiol (E2) can inhibit growth of hormone-independent prostate cancer in animal models. Among the genes up-regulated by E2 are interferon gamma (IFNgamma)-regulated genes, which may be involved in direct ... |
|
| The Single Cell Proteome Project - Cell-Cycle Dependent Protein Expression in Breast Cancer Cell Lines |
JAN 2005 |
28 pages |
| Authors:
Norman J. Dovichi; WASHINGTON UNIV SEATTLE
|
| Protein fingerprints of single MCF7 breast cancer cells were mapped using both one-dimensional and two-dimensional capillary electrophoresis (CE). While one-dimensional CE can resolve dozens of proteins, two-dimensional CE has the potential to resolve hundreds or thousands of proteins with broad dynamic range. Cellular proteins are labeled on column by coupling lysine residues with the fluorogenic reagent 3-(2-furoyl)quinoline-2 carboxaldehyde. Labeled proteins are detected by laser-induced fluorescence in a sheath flow cuvette. ... |
|
| Preventing Wormhole Attacks on Wireless Ad Hoc Networks: A Graph Theoretic Approach |
2005 |
8 pages |
| Authors:
L. Lazos; R. Poovendran; C. Meadows; P. Syverson; L. W. Chang; WASHINGTON UNIV SEATTLE
|
| We study the problem of characterizing the wormhole attack, an attack that can be mounted on a wide range of wireless network protocols without compromising any cryptographic quantity or network node. Making use of geometric random graphs induced by the communication range constraint of the nodes, we present the necessary and sufficient conditions for detecting and defending against wormholes. Using our theory, we also present a defense mechanism based on ... |
|
| Genetic Factors that Affect Tumorigenesis in NF1 |
NOV 2004 |
36 pages |
| Authors:
Karen G. Stephens; WASHINGTON UNIV SEATTLE
|
| Neurofibromatosis type 1 affects 1/4000 individuals worldwide and predisposes to the growth of both benign and malignant tumors. Our research is focused on NF1 microdeletions that are associated with an early onset, and subsequent heavy burden, of cutaneous neurofibromas and predispose to MPNST. We found that these deletions arise by homologous recombination between 51 kb repeat elements (NR1REP) that flank the NF1 gene. We identified recombination hotspots where 69% of ... |
|
| Accelerated Development of MRFM |
28 SEP 2004 |
8 pages |
| Authors:
John A. Sidles; Joseph L. Garbini; WASHINGTON UNIV SEATTLE
|
| We proposed to complete three tasks in this project. These tasks were MRFM imaging with nanometer-scale resolution end-to-end performance analysis of quantum spin imaging and a reference design for a year-20O6 quantum microscope. At the time of this report, nanometer-scale MRFM imaging has been achieved at 8Onm resolution. A performance analysis was completed, and published as an invited paper in the Proceedings of the IEEE on the Classical and Quantum ... |
|
| The Effects of Low to Moderate Intensity Aerobic Exercise on Fatigue in Breast Cancer Patients Following Clinical Treatment |
SEP 2004 |
12 pages |
| Authors:
Katherine L. Kemble; WASHINGTON UNIV SEATTLE
|
| This study will test the effect of low-moderate intensity exercise on fatigue and physical functioning in women who have completed treatment for breast cancer. Sample: Subjects are 10-40 women, ages 20-80. Methods: Participants are randomly assigned to an exercise or control group. The exercise group participates in an exercise program 3 times a week for 10 weeks, Physical functioning is measured by aerobic capacity. Both groups record their weekly level ... |
|
| The Identification of Breast Tumor Antigens Targeted by the Immune Response during Tumor Rejection |
SEP 2004 |
13 pages |
| Authors:
Keith L. Knutson; WASHINGTON UNIV SEATTLE
|
| Previous studies from our laboratory have shown that breast cancer patients can be successfully immunized with HER-2/neu (HER2) peptide vaccines resulting in epitope spreading and improved survival. In autoimmunity, epitope spreading is associated with tissue destruction and may explain why our patients had improved survival. Identifying those antigens to which epitope spreading occurred in this population of breast cancer patients may prove useful in developing cancer vaccine strategies. Our hypothesis ... |
|
| Factors Affecting African American Women's Participation in Breast Cancer Screening Programs: A Qualitative Study of Uninsured Low Income Women |
AUG 2004 |
123 pages |
| Authors:
Frances M. Lewis; WASHINGTON UNIV SEATTLE
|
| Breast cancer screening programs offer the greatest promise for many detection but rates of participation in free screening programs have been disappointing or challenged populations. The purpose of the current study was to elaborate the beliefs and culturally embedded meanings that a population of low income, uninsured African American women held toward breast cancer and breast cancer screening. Both Phase I and 2 work and analyses have been completed. Phase ... |
|
| Quest: A New Approach to Molecular Staging of Tumors |
AUG 2004 |
54 pages |
| Authors:
Karen G. Stephens; WASHINGTON UNIV SEATTLE
|
| Lack of a definitive system for the diagnosis and staging of NF1- related tumors is a major obstacle to investigating the molecular basis of tumorigenesis, to our ability to assess prognosis, and consequently, to the rational design and application of stage-specific therapeutic agents (1-3). Locus-specific changes in copy number are a common feature of many types of tumors, including the neurofibromas and malignant peripheral nerve sheath (MPNST) that develop in ... |
|
| Structural Inheritance in Yeast |
JUL 2004 |
11 pages |
| Authors:
Brian K. Kennedy; Daniel Lockshon; WASHINGTON UNIV SEATTLE
|
| The purpose of this project is to identify and characterize examples of structural inheritance in yeast that are not prions. We described the first such phenomenon, Leu (exp p), and have made progress in this first year of funding in getting a nuclear genetic "handle" on its mechanistic basis by identifying strains that do not exhibit Leu(exp p). Our most significant advance in this initial year has been the development ... |
|
| MCAK and Stathmin Upregulation in Breast Cancer Cells: Etiology and Response to Pharmacologic Reagents |
JUL 2004 |
105 pages |
| Authors:
Linda Wordeman; WASHINGTON UNIV SEATTLE
|
| The goal of this study is to assay the role that two modulators of microtubule dynamics, Mitotic centromere-associated Kinesin (MCAK) and Op18/ stathmin (stathmin) play in the development of cancer. These proteins are elevated in aggressive breast cancer tumors and changes in the levels and activity of these proteins are correlated with aneuploidy and invasiveness. In addition to our previously discovered C-terminal regulation, we have uncovered another major regulatory mechanism ... |
|
| Does the Phenotyping of Disseminated Prostate Cancer Cells in Blood and Bone Marrow Prior to Radical Prostatectomy Provide Prognostic Information? |
JUL 2004 |
13 pages |
| Authors:
Robert L. Vessella; WASHINGTON UNIV SEATTLE
|
| Nearly 20% of men who undergo a radical prostatectomy later relapse with bone metastases. The cellular events that are predictive of subsequent progressive disease remain unknown. We've focused attention on the detection of disseminated prostate cancer (Cap) cells in the blood and bone marrow. Our hypothesis is that these disseminated cells may provide critical insight regarding biomarkers of use in prognostication. We've developed enrichment and isolation techniques that allow the ... |
|
| Modulation of Postmenopausal Steroid Hormone Levels by Phytoestrogens and Correlation with Breast Proliferative Activity and Menopausal Symptoms |
JUL 2004 |
21 pages |
| Authors:
Julie R. Gralow; WASHINGTON UNIV SEATTLE
|
| Overall 5-year survival from breast cancer is now 85% and most surviving women are postmenopausal. Nearly half of postmenopausal American women take estrogen replacement to relieve hot flashes and other symptoms of menopause but this is contraindicated in women with breast cancer. Phytoestrogen supplements can be used as an alternative, but their effect on the risk of cancer recurrence is unknown. Given the mixed results of phytoestrogen studies regarding breast ... |
|
| Novel Functional Screen for New Breast Cancer Genes |
JUN 2004 |
14 pages |
| Authors:
Mary-Claire King; Piri L. Welcsh; WASHINGTON UNIV SEATTLE
|
| Genetic instability is a hallmark of tumor development. Mechanisms for maintenance of genomic stability are heterogeneous and identification of the genes responsible a critical goal of cancer biologists. The very large number of genetic alterations in breast tumors and genetic heterogeneity, even within a single breast tumor, strongly suggests that some mutator mechanism must be involved in breast tumorigenesis. Our hypothesis is that a mutator mechanism contributes to the development ... |
|
| Promoting and Supporting Breastfeeding Among Active Duty Women: An Education Module for Health Professionals |
2004 |
23 pages |
| Authors:
Donna M. Friedline; WASHINGTON UNIV SEATTLE
|
| In recent years, there has been a steady increase in the number of women serving in the United States military. Most women serving on active duty are of childbearing age. The decision to breastfeed while remaining on active duty is an area of potential conflict. While it is well known that full-time employment decreases the incidence and duration of breastfeeding, active duty women may face additional obstacles such as potential ... |
|
| Improving Automatic Sentence Boundary Detection with Confusion Networks |
2004 |
5 pages |
| Authors:
D. Hillard; M. Ostendorf; A. Stolcke; Y. Liu; E. Shriberg; WASHINGTON UNIV SEATTLE
|
| We extend existing methods for automatic sentence boundary detection by leveraging multiple recognizer hypotheses in order to provide robustness to speech recognition errors. For each hypothesized word sequence. an HMM is used to estimate the posterior probability of a sentence boundary at each word boundary. The hypotheses are combined using confusion networks to determine the overall most likely events. Experiments show improved detection of sentences for conversational telephone speech. though ... |
|
| Energy-Aware Secure Multicast Communication in Ad-Hoc Networks Using Geographic Location Information |
2003 |
5 pages |
| Authors:
Loukas Lazos; Radha Poovendran; WASHINGTON UNIV SEATTLE
|
| The problem of securing multicast communications in an energy-constrained ad-hoc network requires the efficient management of cryptographic quantities. We show that existing efficient key distribution techniques for wired networks that rely on logical hierarchies are extremely energy inefficient. We also show that the consideration of the physical location of the members is critical for developing energy-efficient key distribution schemes. By exploiting the spatial correlation between the members of the multicast ... |
|
| Novel Approaches to Preventing Urinary Tract Infection in Women |
SEP 2001 |
|
| Authors:
Ann E. Stapleton; WASHINGTON UNIV SEATTLE
|
 | Urinary tract infections (UTIs), generally caused by Escherichia coli or Staphylococcus saprophyticus, are extremely common among young women. Although UTIs can be treated, we currently lack effective means to prevent frequently UTIs, which occur in 25% of women with first UTI. A necessary prerequisite to UTI is adherence of uropathogens to the vaginal and bladder epithelium. Preliminary studies show that glycosphingolipids (GSLs) are key host cell receptors for E. coli ... |
|
Reports by Corporate Author
