WALTER REED ARMY INST OF RESEARCH WASHINGTON D C

The Effect of Certain Aromatic Compounds on Enzymes Involved in Heme Synthesis,

JUN 1978

Authors: Harold L. Williams; Deadre J. Johnson; Michael J. Haut; Leslie B. Altstatt; WALTER REED ARMY INST OF RESEARCH WASHINGTON D C

The full text of this report is not available and therefore is not for sale. This information is provided for reference purposes only.

In summary, we have used techniques of measuring two enzymes involved in heme synthesis to study in vitro effects of certain organic chemicals on these enzymes as a means of determining structure activity relationships for in vivo predictions. We have attempted to use physiologically attainable concentrations of the chemicals in question and have demonstrated that an effect of the chemicals in question and have demonstrated that an effect can be ...

A New Class of Antimalarial Agents: 2-Acetylpyridine Thiosemicarbazones,

JUN 1978

Authors: John P. Scovill; Joseph F. Bartosevich; Carl J. Mason; Daniel L. Klayman; WALTER REED ARMY INST OF RESEARCH WASHINGTON D C

Cultivation of Human Malaria Parasites,

JUN 1978

Authors: J. D. Haynes; J. D. Chulay; C. L. Diggs; R. E. Desjardins; Cynthia Hall; WALTER REED ARMY INST OF RESEARCH WASHINGTON D C

Scrub Typhus: Mechanism of Infection at the Cellular Level,

JUN 1978

Authors: Edwin P. Ewing Jr.; Akio Takeuchi; Akira Shirai; Joseph V. Osterman; WALTER REED ARMY INST OF RESEARCH WASHINGTON D C

The Survival of St. Louis Encephalitis Virus in Overwintering Mosquitoes,

JUN 1978

10 pages

Authors: Charles L. Bailey; Bruce F. Eldridge; David E. Hayes; WALTER REED ARMY INST OF RESEARCH WASHINGTON D C

The full text of this report is available for sale.

The Behavioral Repertoire. An Instrument Used to Assess Personal and Social Behavior in the SID Project,

14 FEB 1978

Authors: William E. Datel; WALTER REED ARMY INST OF RESEARCH WASHINGTON D C

This report presents the behavioral repertorie data as it was used to assess quantitatively the personal-social behavior of clients in the Service Integration for Deinstitutionalization (SID) project. Also listed are norms (means and standard deviations) for each item in the inventory and for the summarized groupings of items. The three-fold normative sample is comprised of all those mentally ill (MI), mentally retarded (MR), and juvenile offender (JO) clients who were ...

Formalized Information Feedback as a Substitute for Fee Collection in a Military Health Care Delivery System: A Conceptual Underpinning for Program Development,

01 OCT 1977

Authors: William E. Datel; WALTER REED ARMY INST OF RESEARCH WASHINGTON D C

From the analysis made and the studies cited, an approach to improve the health care delivery system in a military setting is deduced. The paper provides the rationale, and the theoretical and empirical justification for proceeding with the construction of a specific plan for program development in the area of health care delivery in a socialized medicine context. The thesis is advanced that social approval and health care services are ...

Research in Biological and Medical Sciences Including Biochemistry, Communicable Disease and Immunology, Internal Medicine, Physiology, Psychiatry, Surgery, and Veterinary Medicine. Volume II.

SEP 1977

Authors: WALTER REED ARMY INST OF RESEARCH WASHINGTON D C

The various subjects covered in this report are listed in the Table of Contents. Abstracts of the individual investigations are included on the DD Form 1498 introducing each work unit report. (Author)

Research in Biological and Medical Sciences Including Biochemistry, Communicable Disease and Immunology, Internal Medicine, Physiology, Psychiatry, Surgery, and Veterinary Medicine. Volume I.

SEP 1977

Authors: WALTER REED ARMY INST OF RESEARCH WASHINGTON D C

Interactions of Entamoeba Histolytica with Host Cells in the Gut Mucosa,

1977

Authors: A. Takeuchi; B. P. Phillips; WALTER REED ARMY INST OF RESEARCH WASHINGTON D C

Germfree guinea pigs were inoculated intracecally with Entamoeba histolytica and the entric flora derived from patients with acute amebic colitis. The enteric tissues were studied, sequentially, at various postinoculation intervals, with the aid of light and electron microscopy. When luminal amebae were observed close to the cecal epithelium, the apposing epithelial cell was found to have protruded in the lumen and making contact with the amebae. Such cells often had ...

Plague Manual,

27 JUL 1976

Authors: M. Bahmanyar; D. C. Cavanaugh; WALTER REED ARMY INST OF RESEARCH WASHINGTON D C

This manual is a compilation of standardization methods to be utilized by Public Health Service personnel working in the surveillance of plague and control. (Author)

Research in Biological and Medical Sciences, Including Biochemistry, Communicable Disease and Immunology Internal Medicine, Nuclear Medicine, Physiology, Psychiatry, Surgery, and Veterinary Medicine.

JUL 1976

Authors: WALTER REED ARMY INST OF RESEARCH WASHINGTON D C

Contents: In-House Laboratory Independent Research; Biomedical Sciences; Communicable Diseases and Immunology; Internal Medicine; and Psychiatry.

Research in Biological and Medical Sciences including Biochemistry, Communicable Disease and Immunology, Internal Medicine, Nuclear Medicine, Physiology, Psychiatry, Surgery, and Veterinary Medicine, Volume II.

Jul-1976

Authors: WALTER REED ARMY INST OF RESEARCH WASHINGTON D C

Contents: Military Preventive Medicine; Combat Surgery; Military Internal Medicine; Military Psychiatry; Microwave Radiation; Malaria Investigations; Tropical Medicine; Biomedical Factors in Drug Abuse; and Military Animal Resources Development.

Immunologic Aspects of Dental Caries. Meningococcal Polysaccharides,

1976

Authors: Malcolm S. Artenstein; WALTER REED ARMY INST OF RESEARCH WASHINGTON D C

Capsular polysaccharides of serogroups A, B and C of Neisseria meningitidis have been tested for safety and immunogenicity in man. Except for a rare local reaction from highly purified polysaccharides no adverse effects have been noted in millions of adults and children who have been vaccinated. An exception to this statement has been those lots of vaccine used in trials in children in Finland in which newer extraction methods were ...

Recent Changes in the Epidemiology of Malaria Relating to Human Ecology,

1976

Authors: Ronald A. Ward; WALTER REED ARMY INST OF RESEARCH WASHINGTON D C

The major factors of human ecology which influence or are likely to influence the spread of malaria are the growth of cities and towns (urbanization), transport and population movements, agricultural and engineering developments (irrigation and building of dams), changes in customs and habits and the introduction of a vector species into an unexploited habitat. Recent examples of changes in the epidemiology of malaria which are related to these factors are ...

Antibody to Hepatitis B Core Antigen,

1976

Authors: Richard G. Allen; Gilbert R. Irwin; WALTER REED ARMY INST OF RESEARCH WASHINGTON D C

The work presented in this paper describes the production of HBcAg in chimpanzees, the development of a sensitive radioimmune test for anti-HBc, and the application of the test to the diagnosis and ultimately, to the prevention of HBV in the military.

Experimental Scrub Typhus Immunogens,

1976

Authors: George H. G. Eisenberg Jr.; Joseph V. Osterman; WALTER REED ARMY INST OF RESEARCH WASHINGTON D C

This study arose from the conviction that an alternate method of rickettsial inactivation was requires. New data suggested that cell-mediated immunity (CMI), rather than antibody, was required for heterologous protection. Since the penetration of mammalian cells by rickettsiae requires active rickettsial metabolism, it was felt that radiation might be a tool that could be used to produce a non-replicating immunogen capable of infecting at the cellular level and possibly eliciting ...

A Summary of Source Data in Military Psychiatric Epidemiology,

DEC 1975

Authors: William E. Datel; WALTER REED ARMY INST OF RESEARCH WASHINGTON D C

The purpose of this paper is to present information on several indicators of psychiatric disease over a period of several decades in United States military populations and to comment upon the meaning and implications of the information presented. Particular attention is paid to the period from 1942 through the first six months of 1973. The United States Army active duty population receives the greatest emphasis in the material presented.

Research in Biological and Medical Sciences, Including Biochemistry, Communicable Disease and Immunology, Internal Medicine, Nuclear Medicine, Physiology, Psychiatry, Surgery, and Veterinary Medicine. Volume I.

JUL 1975

Authors: WALTER REED ARMY INST OF RESEARCH WASHINGTON D C

Contents: In-House Laboratory Independent Research; Biomedical Sciences; Communicable Diseases and Immunology; Internal Medicine; and Analysis and Management of Behavior and Stress in Military Environments.

JUL 1975

Authors: WALTER REED ARMY INST OF RESEARCH WASHINGTON D C

Contents: Epidemiologic Studies of Military Diseases; Combat Surgery; Military Internal Medicine; Military Psychiatry; Biological Effects and Hazards of Microwave Radiation; Malaria Investigations; Military Dog Improvement; Tropical Medicine; and Biomedical Factors in Drug Abuse.

Research in Biological and Medical Sciences Including Biochemistry, Communicable Disease and Immunology, Internal Medicine, Nuclear Medicine, Physiology, Psychiatry, Surgery, and Veterinary Medicine. Volume I.

30 JUN 1974

Authors: WALTER REED ARMY INST OF RESEARCH WASHINGTON D C

;Contents: In-house laboratory independent research; Basic research in support of military medicine; Communicable diseases and immunology; Research in biomedical sciences; Military preventive medicine; Combat surgery; Military internal medicine; Military psychiatry; Radiation injury and protection; Malaria prophylaxis; Military dog improvement; Tropical medicine; Biomedical factors in drug abuse.

30 JUN 1974

Authors: WALTER REED ARMY INST OF RESEARCH WASHINGTON D C

;Contents: Military internal medicine; Military psychiatry; Radiation injury and protection; Malaria prophylaxis; Military dog improvement; Tropical medicine; Biomedical factors in drug abuse.

30 JUN 1973

Authors: WALTER REED ARMY INST OF RESEARCH WASHINGTON D C

;Contents: Tropical medicine; Combat surgery; Military internal medicine; Military psychiatry; Ionizing radiation injury, prevention and treatment; Malaria investigations; Biosensor systems; Biomedical factors in drug abuse.

Research in Biological and Medical Sciences Including in Biochemistry, Communicable Disease and Immunology, Internal Medicine, Nuclear Medicine, Physiology, Psychiatry, Surgery, and Veterinary Medicine. Volume I.

30 JUN 1973

Authors: WALTER REED ARMY INST OF RESEARCH WASHINGTON D C

;Contents: In-house laboratory independent research; Communicable diseases and immunology; Research in biomedical sciences; Basic research in support of military medicine; Tropical medicine; Ionizing radiation injury, prevention and treatment; Malaria prophylaxis; Biosensor systems; Biomedical factors in drug abuse.

Some Biological Effects of Microwave Irradiation in the Rat.

MAR 1973

35 pages

Authors: T. Daryl Hawkins; H. Mark Grove; Thomas W. Heiple; John Schrot; WALTER REED ARMY INST OF RESEARCH WASHINGTON D C

The report describes two major experimental efforts performed by the Microwave Research Department, Walter Reed Army Institute of Research, Walter Reed Army Medical Center. The first study examines the lethal effects of 3000 MHz exposures in rat. The second study, which was performed concurrently with the first, examined behavioral performance decrements in rat as a function of both wavelength and power density. The lethality study indicated that more total energy ...

Meningococcal Antigens: An Immunochemical Approach to the Development of a Meningitis Vaccine,

1973

Authors: Wendell D. Zollinger; WALTER REED ARMY INST OF RESEARCH WASHINGTON D C

The authors isolated the protein and lipopolysaccharide (LPS) components of the meningococcal outer membrane and shown that they are both shared across serogroup lines. Results of specific hemagglutination (HA) assays indicated that persons who acquire systemic meningococcal disease usually develop a substantial increase in antibody titer against both the LPS and the protein antigens. Asymptomatic nasopharyngeal carriers of group B meningococci, however, appeared to respond principally to the protein antigens. ...

Transovarial Transmission of California Encephalitis by Floodwater Mosquitoes,

1973

Authors: James W. Le Duc; William Suyemoto; Bruce F. Eldridge; Philip K. Russell; WALTER REED ARMY INST OF RESEARCH WASHINGTON D C

During arbovirus ecology studies on the eastern shore of Maryland, the Keystone strain of California encephalitis was repeatedly isolated from Aedes atlanticus mosquitoes. The field infection rate from this species remained approximately the same, both between years and during each year studies, even during periods when large numbers of adults were emerging. Further, virus was isolated from among the very first adult A. atlanticus collected and tested, thus suggesting that ...

30 JUN 1972

Authors: WALTER REED ARMY INST OF RESEARCH WASHINGTON D C

Contents: Communicable diseases and immunology; Surgery; Psychiatry; Biochemistry; Military preventive medicine; Tropical and subtropical military medical research; Combat surgery, Military internal medicine and Military psychiatry; Ionizing radiation injury, prevention and treatment; Malaria investigations; and Biosensor systems.

30 JUN 1972

Authors: WALTER REED ARMY INST OF RESEARCH WASHINGTON D C

;Contents: Military preventive medicine; Tropical and subtropical military medical research; Combat surgery, military internal medicine, military psychiatry; Ionizing radiation injury, prevention and treatment; Malaria investigations; and Biosensor systems.

Digest of Papers. Joint U.S. Army/Georgia Institute of Technology Microwave Dosimetry Workshop 1-2 June 1972.

02 JUN 1972

Authors: H. Mark Grove; WALTER REED ARMY INST OF RESEARCH WASHINGTON D C

The objective of the workshop was to interchange the latest information on techniques of electromagnetic measurements in a biological research context. This report is a compilation of summaries of the papers which were presented. (Modified author abstract)

30 JUN 1971

Authors: WALTER REED ARMY INST OF RESEARCH WASHINGTON D C

;Contents: In-house laboratory independent research; Communicable diseases and immunology; Research in biomedical sciences; Basic research in support of military medicine; Military preventive medicine; Military medical research program S. E. Asia; Combat surgery; Military internal medicine; Military psychiatry; Ionizing radiation injury, prevention and treatment; Malaria prophylaxis; Biosensor systems.

INVESTIGATION OF A NEW DISEASE OF MILITARY DOGS,

1970

Authors: Robert M. Nims; David L. Huxsoll; Paul K. Hilderbrandt; Jerry S. Walker; WALTER REED ARMY INST OF RESEARCH WASHINGTON D C

In July 1968, an epizootic of a fatal hemorrhagic disease, characterized by unilateral or bilateral epistaxis, began in U. S. military dogs in Southeast Asia. The disease appeared to be the same as Tropical Canine Pancytopenia (TCP) described by the British in military dogs in Singapore as early as 1963, and was similar to a disease reported by the French in military dogs in Tunisia. A coordinated investigation of the ...

OBSTACLES IN OXYGEN TRANSPORT DURING AEROMEDICAL EVACUATION,

1970

Authors: John N. Henry; Teruo Matsumoto; George Hayes; WALTER REED ARMY INST OF RESEARCH WASHINGTON D C

Aeromedical evacuation is well tolerated by the majority of casualties evacuated from Viet Nam to Japan. Low cabin altitudes are better tolerated by all injury types. Cabin altitudes of 6,700 and above are poorly tolerated by the S.I. and V.S.I. (22% of all evacuees). The most hypoxemic patients during flight were those with fractured femurs, multiple extremity fractures and abdominal cases. The lowest tolerance to flight was observed in those ...

THE CHEMISTRY OF ORGANIC THIOSULFATES,

1968

Authors: Daniel L. Klayman; Robert J. Shine; WALTER REED ARMY INST OF RESEARCH WASHINGTON D C

PATTERN OF PHYSIOLOGICAL VARIABLES IN SLOW BLOOD LOSS SHOCK,

JUN 1966

Authors: Karl Stecher Jr; WALTER REED ARMY INST OF RESEARCH WASHINGTON D C

A new method of studying the effects of hemorrhage in monkeys was devised. Animals were extensively instrumented, placed in Walter Reed type primate chairs, and allowed to recover from operation before the experiments began. This study of the natural history of hemorrhagic shock can be of great value to physicians responsible for patients in shock or in an impending shock state. ABP's fall does not occur until considerable blood volume ...

THE REPLACEMENT OF LARGE VEINS WITH FREE INVERTED SEGMENTS OF SMALL BOWEL,

JUN 1966

Authors: Teruo Matsumoto ; Robert H. Holmes ; Claude O. Burdick ; Charles A. Heisterkamp ; Thomas J. O'Connell Jr; WALTER REED ARMY INST OF RESEARCH WASHINGTON D C

Experimental work indicates that inverted free segments of small bowel can be used successfully as autografts in the replacement of segments of major veins in dogs. Success has been obtained using a graft in which the mucosa, muscularis, and serosa have been removed by abrasion. The resultant tube is then comprised essentially of submucosa which provides a trellis for complete endothelialization. When the ostium of the graft is of large ...

A COMPARISON BETWEEN THE EFFECTS OF EXPOSURE TO A MIXED FISSION SPECTRUM DELIVERED IN A SINGLE 'PULSE' AND X-RAYS DELIVERED AT A SLOWER RATE UPON THE CONDITIONED AVOIDANCE BEHAVIOR OF PRIMATES.

OCT 1965

Authors: Joseph C. Sharp; Barbara K. Keller; WALTER REED ARMY INST OF RESEARCH WASHINGTON D C

SOLUBLE ANTIGEN FLUORESCENT-ANTIBODY TECHNIQUE,

22 FEB 1965

Authors: Andre J. Toussaint; Robert I. Anderson; WALTER REED ARMY INST OF RESEARCH WASHINGTON D C

An indirect fluorescent-antibody (FA) procedure employing soluble antigen fixed onto an artificial matrix was developed, and a mechanical means for reading of test results was devised. The method employs two small cellulose acetate paper discs for each test. One disc contains soluble antigen diluted in 1% bovine serum albumin (BSA); the other contains only 1% BSA and serves as a control. After testing by the indirect FA procedure, the results ...

CORTICOSTEROID RESPONSES TO HOSPITAL ADMISSION,

18 JAN 1965

Authors: John W. Mason; Edward J. Sachar; Jacob R. Fishman; David A. Hamburg; Joseph H. Handlon; WALTER REED ARMY INST OF RESEARCH WASHINGTON D C

Urinary 17-OHCS levels were measured in 60 normal adults during their admission to a hospital control research ward. 17-OHCS levels were significantly higher on the day of admission than later in hospitalization. Evidence is offered that these 17-OHCS changes were part of the subjects' psychoendocrine response to environmental change. A considerable range of group and individual differences was observed, and the feasibility of using hospital admission as a predictable means ...

ANODIC-STRIPPING VOLTAMMETRY OF BIOLOGICAL SAMPLES,

12 JAN 1965

Authors: Carvel L. Newberry; Gary D. Christian; WALTER REED ARMY INST OF RESEARCH WASHINGTON D C

Anodic-stripping voltammetry can be applied directly to biological samples following dry-ashing and dissolution in purified water. Measurements have been made of pH and resistance of solution and linearity has been established between concentration of metal ion and stripping peak height. A standard addition method is recommended to obtain qualitative and quantitative results. Stripping peak potentials vs. the mercury pool anode of some common metals in several different biological sample solutions ...

THE INFLUENCE OF EXTRACORPOREAL HANDLING OF BLOOD ON HEMORRHAGIC SHOCK IN DOGS,

1965

Authors: Robert M. Hardaway; Dale G. Johnson; Donald N. Houchin; Edward B. Jenkins; John W. Burns; WALTER REED ARMY INST OF RESEARCH WASHINGTON D C

Summary and conclusions: (1) Activation of surface clotting factors during extracorporeal handling of blood will greatly increase the mortality in hemorrhagic shock in dogs. (2) With careful handling of the blood exposing it only to plastic surfaces and avoiding metal, glass and air, dogs may be maintained for long periods at low pressures without the onset of irreversible shock. (3) Saline is nontoxic and quite helpful in hemorrhagic shock, whereas ...

BEHAVIOR OF RUBELLA VIRUS IN ADULT POPULATIONS,

1965

Authors: E. L. Buecher; WALTER REED ARMY INST OF RESEARCH WASHINGTON D C

DIALYSIS FOR INTOXICATION WITH LIPID SOLUBLE DRUGS: ENHANCEMENT OF GLUTETHIMIDE EXTRACTION WITH LIPID DIALYSATE,

1965

Authors: James H. Shinaberger; Leroy Shear; Lloyd E. Clayton; Kevin G. Barry; Marjorie Knowlton; WALTER REED ARMY INST OF RESEARCH WASHINGTON D C

These in vivo studies demonstrate that the removal of glutethimide during dialysis is significantly increased when lipid is substituted for the usual aqueous dialysis solution. The very low water solubility of many lipid soluble compounds probably limits their removal by routine dialysis methods. Their high lipid solubility not only permits relatively small volumes of lipid dialysate to contain large amounts of these drugs, but also prevents back diffusion after they ...

ELECTRON SPIN RESONANCE SIGNALS OF TETRAZOLIUM COMPOUNDS,

1965

Authors: Robert T. Lofberg; WALTER REED ARMY INST OF RESEARCH WASHINGTON D C

A strong ESR signal was observed in 2, 3, 5-triphenyl formazan (I) which could not be explained by the compound's structural formula. Subsequent studies revealed that the signal resulted from an unascertainable free radical impurity. The same impurity appeared regardless of the reduction method used during the preparation of I. Several implications are discussed.

THE ABSORPTION OF NONFERROUS METALS IN IRON DEFICIENCY,

14 DEC 1964

Authors: Simeon Pollack; James N. George; Richard C. Reba; Richard M. Kaufman; William H. Crosby; WALTER REED ARMY INST OF RESEARCH WASHINGTON D C

The intestinal absorption of cobalt and manganese was increased in rats rendered iron deficient by bleeding and diet. The intestinal absorption of cesium, magnesium, mercury, calcium, and copper was not increased in rats consuming an iron-deficient diet but was unchanged in bled rats. (Author)

URINARY CATECHOLAMINE RESPONSES ASSOCIATED WITH HOSPITAL ADMISSION IN NORMAL HUMAN SUBJECTS,

30 OCT 1964

Authors: Wiley W. TOLSON; John W. Mason; Edward J. Sachar; David A. Hamburg; Joseph H. Handlon; WALTER REED ARMY INST OF RESEARCH WASHINGTON D C

Urinary epinephrine, norepinephrine and 17--OH--CS (17-hydroxycorticosteroid) levels were higher on the initial day of hospitalization than on subsequent occasions during hospital stay in two groups of normal young adults. A positive correlation was observed between the three hormones in this situation and the possible relationship of these findings to earlier related work in the monkey is discussed. Although group and individual differences in degree of response were noted, limiting the ...

THE AMPEROMETRIC TITRATION OF TOTAL AND INTERCHAIN DISULFIDE BONDS IN GAMMA GLOBULIN,

03 SEP 1964

Authors: Gary D. Christian; Peter H. Schur; WALTER REED ARMY INST OF RESEARCH WASHINGTON D C

The total number of disulfide bonds and the corresponding number of interchain disulfide bonds in several gamma globulins are as follows: 7-S-rabbit 22.5 = 0.5 and 3; 5-S-rabbit - 17 and 3; 7-S-sheep 22 and 0; 5-S-sheep - 15 and 0; 7-S-human - 18-19 and 4; 5-S-human - 14 and 4.

CHROMOSOMAL ANALYSES OF CHILDREN WITH MULTIPLE CONGENITAL MALFORMATIONS.

JUL 1964

Authors: Robert G. Scherz; WALTER REED ARMY INST OF RESEARCH WASHINGTON D C

Ninety-five patients with multiple congenital anomalies have had chromosomal analyses performed on peripheral blood leucocytes. Seventy-five had detectable chromosome anomalies in this select group. Chromosomal analyses thus far are useful for establishing and confirming clinical diagnoses, aid in genetic counseling, and are useful tools for probing deeper into the causations of multiple congenital malformations. This sample of patients is biased by the selective population referred to Walter Reed General Hospital ...

HEPATIC IRON STORAGE AND ERYTHROKINETICS AFTER PORTACAVAL SHUNT,

24 MAR 1964

Authors: Raymond C. Doberneck; Arthur S. Morse; Marcel E. Conrad; Ann R. Berman; WALTER REED ARMY INST OF RESEARCH WASHINGTON D C

The concentration of hepatic storage iron (nonheme iron) is increased by 62.3 percent after portacaval shunting in dogs. Such increase is presumably due to the presence of an increased amount of hemosiderin, as observed on microscopic examination of sections of liver. Because of the known reduction of liver volume and the suspected reduction of hepatic ferritin concentration after shunting, the increase in the concentration of hepatic storage iron is a ...

SOME BIOCHEMICAL AND PHYSICAL PROPERTIES OF THE HUMAN PERMEABILITY GLOBULINS,

02 FEB 1964

Authors: L. J. Kagen; WALTER REED ARMY INST OF RESEARCH WASHINGTON D C

The permeability activity of globulin A is inhibited by C prime 1 esterase inhibitor, soy bean trypsin inhibitor, and di-isopropylfluorophosphate. TAMe portects against this DFP inhibition, and preparations of A contain SBTI inhibitable TAMe esterase. Preparations of A are also SBTI inhibitable kininogenases which liberate a smooth muscle contracting factor from both heated (63C, 1 hr.) and unheated plasma. A is estimated to have a sedimentation coefficient of approximately 11 ...