| Spinal Subarachnoid Injection of Somatostatin Causes Neurological Deficits and Neuronal Injury in Rats |
88 |
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| Authors:
Joseph B. Long; WALTER REED ARMY INST OF RESEARCH WASHINGTON DC NEUROPHARMACOLOGY BRANCH
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 | Intrathecal administration of somatostatin has recently been clinically investigated as a means to treat intractable pain in humans. Significant reductions in patient pain scores were recorded following bolus i.t. injections of 152.6 nmol of somatostatin, followed by i.t. infusions of 6.1-30.5 nmol/h. The present findings signal a need for caution and more comparative data before somatostatin is further used as a spinal analgesic in humans. The tetradecapeptide somatostatin produced dose-related ... |
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| Cardiovascular Effects of Dynorphin A (1-13) in Conscious Rats and Its Modulation of Morphine Bradycardia Over Time |
Jan 1987 |
5 pages |
| Authors:
Charles E Glatt; Julie R Kenner; Joseph B Long; John W Holaday; WALTER REED ARMY INST OF RESEARCH WASHINGTON DC NEUROPHARMACOLOGY BRANCH
|
 | Pharmacological studies with alkaloid and peptide opioid agonists and antagonists have revealed a confusing array of cardiovascular responses that differ according to the opioid ligand used, state of consciousness of experimental animals, site (s) or routes of injection, doses, species, experimental stressors,and other variables 6, 7, 17. Of the many endogenous opioid peptides described to date, the autonomic effects of dynorphin-related peptides are the least studied. Although the short-term cardiovascular ... |
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| Immunosuppressive Effects of Chronic Morphine Treatment in Mice |
87 |
|
| Authors:
Henry U. Bryant; Edward W. Bernton; John W. Holaday; WALTER REED ARMY INST OF RESEARCH WASHINGTON DC NEUROPHARMACOLOGY BRANCH
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| Opioids, such as morphine and their endogenous peptide counterparts produce multiple pharmacological effects and subserve many physiological functions. In addition to their well characterized effects on pain perception and gastrointestinal motility, opioid agonists and endogenous opioid peptides affect various cardiovascular, endocrine and behavioral parameters. Several lines of evidence suggest that opioids are also immunomodulatory agents. An increase in the incidence of infectious disease has been reported in opioid addicts, as ... |
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| The Effects of Diisopropyl Phosphorogluoridate (DFP) of Inter-Response Time and Circadian Patterns of Lever Pressing in Rats |
86 |
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| Authors:
Thomas G. Raslear; John R. Leu; Laurence Simmons; WALTER REED ARMY INST OF RESEARCH WASHINGTON DC NEUROPHARMACOLOGY BRANCH
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| Rats were injected with saline, 1.0 mg/kg or 2.6 mg/kg of diisopropyl phosphorofluoridate (DFP). Three days later the animals were placed in cages in which they could press a lever to obtain their entire daily ration of food. The time of day at which responses occurred and the time between successive responses were recorded over a six day period to determine the circadian pattern of lever-pressing and the distribution of ... |
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