WALTER REED ARMY INST OF RESEARCH WASHINGTON DC DIV OF NEUROSCIENCES
Click on the titles below to find US government-authored or -collected reports written by WALTER REED ARMY INST OF RESEARCH WASHINGTON DC DIV OF NEUROSCIENCES
While neurobehavioral effects of acute exposure to toxic levels of chemical warfare nerve agents (CWNA) have been characterized; much less is known about the effects of repeated exposure to non-convulsive levels of CWNA. In Exp. 1, male mice that received repeated exposure (1/day x 5 days/wk x 2 wk) to 0.4 LD50 of the nerve agent VX had much lower activity in the home cage, relative to saline treated mice, ...
This study reports an upregulation of the neuro-inflammatory gene response using quantitative RT-PCR following soman exposure in rats. Male Sprague-Dawley rats were pre-treated with HI-6 (125 mg/kg, i.p.) and exposed 30 min later to 1.6x LD50 of soman (180 microgram/kg, s.c.) followed at 1 min by atropine (4 mg/kg, i.m.). Initially, a significant upregulation of TNF-alpha and VCAM- 1 mRNA levels were measured 2 h post-exposure followed at 6 h ...
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