| Annual Meeting of the American Society of Tropical Medicine and Hygiene (39th) Held in New Orleans, Louisiana on November 4-8, 1990 |
92 |
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| Authors:
Jonathan I. Ravdin; VIRGINIA UNIV CHARLOTTESVILLE SCHOOL OF MEDICINE
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| Inhibition of Malarial DNA Polymerase Alpha. |
14 NOV 1990 |
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| Authors:
Sidney M. Hecht; VIRGINIA UNIV CHARLOTTESVILLE SCHOOL OF MEDICINE
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 | Plant extracts have been surveyed in an effort to locate natural principles capable of mediating potent, specific inhibition of malaria DNA polymerase alpha. Several extracts containing putative polymerase inhibitors have been shown to inhibit cultured Plasmodium falciparum. Also underway are efforts to clone and express the gene for P. falciparum. Also underway are efforts to clone and express the gene for P. falciparum DNA polymerase alpha, which would provide access ... |
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| The Effect of Moderate Pressure on Biological Processes |
07 JUN 89 |
10 pages |
| Authors:
Rodney L. Biltonen; M. L. Johnson; VIRGINIA UNIV CHARLOTTESVILLE SCHOOL OF MEDICINE
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 | A volume-perturbation calorimeter, which measures time-dependent temperature changes in response to a pressure perturbation, has been used to probe the relaxation dynamics of phospholipid bilayers in the gel to liquid crystalline transition region. The principal relaxation time is between 50 milliseconds to 5 sec. The relaxation dynamics appear to be insensitive to pressure over a pressure range of 10 to 20 atm., thus suggesting that the most important effect of ... |
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| Studies of the Biological and Molecular Basis of the Inhibition of Activity of Phagocytic Cells by Anthrax Toxin |
JAN 1988 |
9 pages |
| Authors:
George G. Wright; VIRGINIA UNIV CHARLOTTESVILLE SCHOOL OF MEDICINE
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| The primary effect of anthrax toxin on polymorphonclear neutrophils (PMN) is the inhibition of priming by bacterial products, as represented by lipopolysaccharide (LPS) and by muramyl dipeptide, a synthetic mitogen to bacterial peptidoglycans. Priming increases superoxide release and enzyme exocytosis of PMN after simulation with chemotactic peptide; inhibition of priming by prior treatment with toxin reduces these critical antimicrobial functions. These observations could explain the major contribution of the toxin ... |
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| Direct Assessment of Synaptic Modification Rules |
20 FEB 87 |
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| Authors:
William B. Levy; VIRGINIA UNIV CHARLOTTESVILLE SCHOOL OF MEDICINE
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| This research has related experimental data on synaptic modification to the development of algebraic synaptic modification rules. The experimental findings support the following ideas: 1) There is a threshold for either synaptic potentiation or depression in dentate hyrus cells; 2) both potentiation and depression are equally long-term and are thus treated equally in the synaptic modification rule equation; 3) associativity means co-activity between pre- and postsynaptic elements; 4) the rate ... |
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| Studies of the Biological and Molecular Basis of the Inhibition of Activity of Phagocytic Cells by Anthrax Toxin |
MAR 85 |
29 pages |
| Authors:
George C. Wright; Gerald L. Mandell; Erik L. Hewlett; VIRGINIA UNIV CHARLOTTESVILLE SCHOOL OF MEDICINE
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| This report presents investigations of the effects of the toxin of Bacillus anthracis on phagocytic cells, and the biochemical reactions associated with these effects. Combinations of protective antigen (PA) plus edema factor (EF), and PA plus lethal factor (LF) markedly stimulated chemotaxis of human polymorphonuclear neutrophilis (PMN), but had little effect on random migration. These effects were accompanied by a marked inhibition of the oxidative activity of these cells, as ... |
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| Direct Assessment of Synaptic Modification Rules |
15 JUN 1984 |
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| Authors:
W. B. Levy; VIRGINIA UNIV CHARLOTTESVILLE SCHOOL OF MEDICINE
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| Our objectives are to quantify synaptic modification rules and to understand them in a context of simple neural networks capable of pattern recognition and clustering. The experimental work plus considerations of parsimony favors one particular form of the excitatory synaptic modification rule. Modification of the translation of synaptic activation into cell firing may well the governed by a separate rule. Although different than the first rule, simple computer models show ... |
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| Direct Assessment of Synaptic Modification Rules |
01 JAN 84 |
3 pages |
| Authors:
William B. Levy; VIRGINIA UNIV CHARLOTTESVILLE SCHOOL OF MEDICINE
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| We have spent considerable time reprogramming our computer programs for data acquisition and evaluation. This is an important effort since we were previously unable to study simultaneously the synaptic response and the cell discharge. This improvement has become particularly critical since the ongoing evaluation of data gathered last year shows strong support for the existence of two distinct adaptive processes. One process modifies the synaptic response, and another adaptive process ... |
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| The Effects of Acute Alterations in Hemodynamics Oxygen Availability and Acid-Base Balance on the Permeability of the Gastric Mucosa |
31 MAR 81 |
23 pages |
| Authors:
Wallace P. Ritchie Jr; VIRGINIA UNIV CHARLOTTESVILLE SCHOOL OF MEDICINE
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| Using a previously described model for acute gastric mucosal ulcerogensis, studies indicate the following: (1) Systemic 16,16 DM PGE2 is cytoprotective in bile acid treated gastric mucosa. Such cytoprotection is dose dependent, is not a function of mucosal blood flow, and is unrelated to bicarbonate secretion. Rather the data suggest that maintenance of normal mucosal transport is responsible. (2) De-conjugated bile acids induce significantly greater physiologic damage to proximal gastric ... |
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| The Effects of Acute Alterations in Hemodynamics, Oxygen Availability, and Acid-Base Balance on the Permeability of the Gastric Mucosa. |
MAR 1980 |
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| Authors:
Wallace P. Ritchie Jr; VIRGINIA UNIV CHARLOTTESVILLE SCHOOL OF MEDICINE
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| Using a previously described model for acute gastric mucosal ulcerogenesis, developed under the auspices of the current contract, studies from this laboratory during the period covered by this progress report indicate (1) that, in the face of an imposed topical acid load, H1 and H2 receptor blockade, either alone or in combination, effects no change in gastric mucosal permeability to cations or in mucosal blood flow and affords no protection ... |
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| The Effects of Acute Alterations in Hemodynamics, Oxygen Availability, and Acid-Base Balance in the Permeability of the Gastric Mucosa. |
24 MAY 1978 |
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| Authors:
Wallace P. Ritchie Jr; VIRGINIA UNIV CHARLOTTESVILLE SCHOOL OF MEDICINE
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| Using a previously described model for acute gastric mucosal ulcerogenesis (Gastroent.68:699, 1975), studies carried out in this laboratory indicate that acute gastric mucosal ulcerogenesis may be a consequence of uncompensated tissue acidosis; that the topical application of 16,16 DM PGE2 significantly ameliorates bile acid-ischemia induced acute mucosal lesion formation; and that intravenous metiamide is cyto-protective under the same circumstances, perhaps as a consequence of its ability to decrease the apparent ... |
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| The Effects of Acute Alterations in Hemodynamics, Oxygen Availability and Acid-Base Balance on the Permeability of the Gastric Mucosa. |
01 SEP 1977 |
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| Authors:
Wallace P. Ritchie Jr; VIRGINIA UNIV CHARLOTTESVILLE SCHOOL OF MEDICINE
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| Using a previously described model for acute gastric mucosal ulcerogenesis (Gastroent. 68:699, 1975), studies indicated that methylprednisolone significantly protects against acute lesion formation by enhancing mucosal blood flow; that, at constant concentration of bile acid, lesion formation is a linear function of the concentration of hydrogen ion; and that, under non-ischemic conditions, in addition to affection significant inhibition of histamine stimulated H+ secretion, metiamide produces a concomitant reduction in venous ... |
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| The Effects of Acute Alterations in Hemodynamics, Oxygen Availability and Acid-Base Balance on the Permeability of the Gastric Mucosa. |
20 JUL 1976 |
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| Authors:
Wallace P. Ritchie Jr; VIRGINIA UNIV CHARLOTTESVILLE SCHOOL OF MEDICINE
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| Using a previously described model for acute gastric mucosal ulcerogenesis (Gastroent. 68: 699, 1975), studies indicated that the glycine conjugates of cholic acid possesses a potential for ulcerogenesis equal to that of the taurine conjugates; that acute ulcerogenesis is associated with a significant reduction in gastric mucosal ATP content; and that the severity of mucosal injury under these circumstances is bile acid concentration dependent. |
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| A COOPERATIVE PROGRAM OF FUNDAMENTAL RESEARCH AS RELATED TO JET PROPULSION, OFFICE OF NAVAL RESEARCH, DEPARTMENT OF THE NAVY |
Apr-1963 |
81 pages |
| Authors:
VIRGINIA UNIV CHARLOTTESVILLE SCHOOL OF MEDICINE
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| GROUP REINFORCEMENT OF INDIVIDUAL RESPONSE. EXPERIMENTS IN VERBAL BEHAVIOR. I |
APR 1960 |
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| Authors:
Arthur J. Bachrach; DOUGLAS K. CANDLAND; JANICE T. GIBSON; VIRGINIA UNIV CHARLOTTESVILLE SCHOOL OF MEDICINE
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| Proceedings of the Tri-Service Conference on Biological Effects of Microwave Energy (2nd), 8-10 July 1958 |
Sep 1958 |
277 pages |
| Authors:
VIRGINIA UNIV CHARLOTTESVILLE SCHOOL OF MEDICINE
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| EFFECT OF DRUGS ON THERMODYNAMICS OF ENZYME ACTION |
30 SEP 1955 |
2 pages |
| Authors:
CHALMERS L. GEMMILL; VIRGINIA UNIV CHARLOTTESVILLE SCHOOL OF MEDICINE
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| THE INFLUENCE OF COMPLEX TASK VARIABLES ON THE RELATIVE EFFICIENCY OF AUDITORY AND VISUAL MESSAGE PRESENTATION |
APR 1955 |
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| Authors:
L. STARLING REID; WILLIAM H. MORSE; VIRGINIA UNIV CHARLOTTESVILLE SCHOOL OF MEDICINE
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| THE INFLUENCE OF MESSAGE LENGTH AND DISTRACTING TASK COMPLEXITY |
APR 1955 |
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| Authors:
RICHARD H. HENNEMAN; THOMAS L. MATTHEWS; VIRGINIA UNIV CHARLOTTESVILLE SCHOOL OF MEDICINE
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| THE INFLUENCE OF MESSAGE DISTORTION AND MESSAGE FAMILIARITY |
APR 1955 |
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| Authors:
JAMES G. HOLLAND; WILLIAM A. LEE; VIRGINIA UNIV CHARLOTTESVILLE SCHOOL OF MEDICINE
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| The Concept of Response Restriction Applied to Dial Reading. |
APR 1955 |
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| Authors:
WILLIAM A. LEE; MELVIN FREITAG; VIRGINIA UNIV CHARLOTTESVILLE SCHOOL OF MEDICINE
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| THE INFLUENCE OF CATEGORICAL CUING ON THE IDENTIFICATION OF VISUALLY DISTORTED WORDS SELECTED FROM A LOGICALLY ORGANIZED POPULATION |
APR 1955 |
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| Authors:
RICHARD H. HENNEMAN; L. STARLING REID; Eugene R. Long; VIRGINIA UNIV CHARLOTTESVILLE SCHOOL OF MEDICINE
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| A COMPARISON OF THE VISUAL AND AUDITORY SENSES AS CHANNELS FOR DATA PRESENTATION |
AUG 1954 |
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| Authors:
RICHARD H. HENNEMAN; Eugene R. Long; VIRGINIA UNIV CHARLOTTESVILLE SCHOOL OF MEDICINE
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| THE THIRD OF A SERIES OF REPORTS ON EXPERIMENTAL ANALYSIS OF COMPLEX TASK PERFORMANCE THE INFLUENCE OF STIMULUS SIMILARITY AND STIMULUS RATE |
MAY 1954 |
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| Authors:
L. STARLING; JAMES G. HOLLAND; VIRGINIA UNIV CHARLOTTESVILLE SCHOOL OF MEDICINE
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| EFFECTS OF DRUGS ON THE THERMODYNAMICS OF ENZYME ACTION |
31 DEC 1952 |
1 pages |
| Authors:
CHALMERS L. GEMMILL; VIRGINIA UNIV CHARLOTTESVILLE SCHOOL OF MEDICINE
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Reports by Corporate Author
