| Simulation of Protein and Peptide-Based Biomaterials |
13 FEB 2002 |
5 pages |
| Authors:
Valerie Daggett; UNIV OF WASHINGTON SEATTLE DEPT OF MEDICINAL CHEMISTRY
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 | The overall goal of the proposed research is to pursue realistic molecular modeling studies of the stability, dynamics, structure, function, and folding of proteins and protein-based biomaterials in solution. Simulations of elastin-based polymers will investigate the driving forces and mechanism for the unusual temperature-dependent conformational changes, knowledge that will assist in redesign of this system for specific applications and the design of other such molecules. Studies of the stabilities of ... |
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| Simulation of Protein Structure, Dynamics and Function in Organic Media |
JUL 1998 |
4 pages |
| Authors:
Valerie Daggett; UNIV OF WASHINGTON SEATTLE DEPT OF MEDICINAL CHEMISTRY
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| The overall goal of our ONR-sponsored research is to pursue realistic molecular modeling strudies pertinnent to the related properties of protein stability, dynamics, structure, function, and folding in aqueous solution. We have developed mixed solvent systems to investigate the conformational behavior of peptides and proteins in response to a change in environment. We have also been studying hydrophobic hydration and how it may affect the diffusivity of molecules and how ... |
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| Critical Current Density and Resistivity Measurements for Long Patterned Lines in Tl2Ba2CaCu2O8 Thin Films |
93 |
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| Authors:
W. L. Holstein; C. Wilker; D. B. Laubacher; D. W. Face; P. Pang; UNIV OF WASHINGTON SEATTLE DEPT OF MEDICINAL CHEMISTRY
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 | Epitaxial Tl2Ba2CaCu2O8 films of thickness 0.65 +/- 0.05 microns and T(sub c) of 105 +/- 1 K were prepared on (100) LaAlO3 through a two-step post- deposition thallination process and patterned by standard photolithographic techniques and ion beam milling. Using the voltage per unit length criteria E(sub c) = 1.0 microvolt/cm, transport critical current density J(sub c) in zero applied field was measured to be 1.04 x10(7) A/sq cm at ... |
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| Synthesis and Applications of Isotopically Labelled Compounds: Proceedings of the International Symposium Held in Innsbruck, Austria on 17-21 July 1988 |
JUL 88 |
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| Authors:
Thomas A. Baillie; John R. Jones; UNIV OF WASHINGTON SEATTLE DEPT OF MEDICINAL CHEMISTRY
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| Stable isotopes (2H, 13C) are useful for studies on the metabolism of endogenous or exogenous compounds. GC/MS makes it possible to measure partial loss of 2H by exchange from polydeute-rated molecules and to detect compartmentation of precursors. Oxidoreduction can be studied by measurements of the loss of isotope from the carbon carrying the hydroxyl group. Label in the coenzyme can be corrected for by the use of mixtures of differently ... |
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