| Near-infrared Spectroscopy to Reduce the Prophylactic Fasciotomies for and Missed Cases of Acute Compartment Syndrome in Soldiers Injured in OEF/OIF |
Oct 2010 |
57 pages |
| Authors:
Brett Freedman; TRUE RESEARCH FOUNDATION SAN ANTONIO TX
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 | The near-infrared spectroscopy (NIRS) research project is a three-part project over three years, intended to validate the accuracy and reliability of a specific NIRS sensor (INVOS, Somanetics Inc, Troy, MI) in diagnosing acute compartment syndrome in injured combat soldiers. Part 1 is a planned series of two 6-month observational studies. Patients will receive continuous NIRS and vital sign monitoring throughout their standard course of care, first at Landstuhl Regional Medical ... |
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| Circadian Genes and Risk for Prostate Cancer |
SEP 2010 |
7 pages |
| Authors:
Ann W. Hsing; TRUE RESEARCH FOUNDATION SAN ANTONIO TX
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| We propose that genetic susceptibility to prostate cancer may be in part due to variations in the core circadian genes that regulate circadian rhythms and that serum sex steroid hormone levels modify the effect of circadian gene polymorphisms on prostate cancer risk. Our study is nested within the Prostate Cancer Prevention Trial (PCPT), a randomized placebo-controlled clinical trial to determine if finasteride (an inhibitor of androgen bioactivation) could prevent prostate ... |
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| Helmet Sensor - Transfer Function and Model Development |
Sep 2010 |
239 pages |
| Authors:
B J McEntire; V C Chancey; Timothy Walilko; Gregory T Rule; Gregory Weiss; Cameron Bass; Jay Shridharani; TRUE RESEARCH FOUNDATION SAN ANTONIO TX
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| The Vice Chief of Staff of the Army (VCSA) directed that Soldier combat helmets be fitted with electronic sensor technologies to sense and record helmet response to dynamic events. These events could be exposure to blast events (IEDs), ballistic impacts, and/or blunt impacts. The sensors record orthogonal accelerations and blast overpressure levels. However, since helmets are not rigidly coupled to the head, and are not rigid bodies and often experience ... |
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| Early Decompressive Craniectomy for Severe Penetrating and Closed Head Injury During Wartime |
May 2010 |
5 pages |
| Authors:
Randy S Bell; Corey M Mossop; Michael S Dirks; Frederick L Stephens; Lisa Mulligan; Robert Ecker; Chris J Neal; Arnand Kumar; Teodoro Tigno; Rocco A Armonda; TRUE RESEARCH FOUNDATION SAN ANTONIO TX
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| Decompressive craniectomy has defined this era of damage-control wartime neurosurgery. Injuries that in previous conflicts were treated in an expectant manner are now aggressively decompressed at the far-forward Combat Support Hospital and transferred to Walter Reed Army Medical Center (WRAMC) and National Naval Medical Center (NNMC) in Bethesda for definitive care. The purpose of this paper is to examine the baseline characteristics of those injured warriors who received decompressive craniectomies. ... |
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| Aerobiology in Biodefense III |
Oct 2009 |
6 pages |
| Authors:
Ashley Bordas; TRUE RESEARCH FOUNDATION SAN ANTONIO TX
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| In July 2009 the Aerobiology in Biodefense III Symposium was held at Rocky Gap Conference Center in Cumberland, MD. The Symposium was co-sponsored, in part, by the Defense Threat Reduction Agency through a grant awarded by the U.S. Army Medical Research and Materiel Command. Other co-sponsors included the National Institute of Allergies and Infectious Diseases, the National Biodefense Analysis and Countermeasures Center, and the TRUE Research Foundation. The Symposium provided ... |
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| Circadian Genes and Risk for Prostate Cancer |
Mar 2009 |
7 pages |
| Authors:
Ann W Hsing; TRUE RESEARCH FOUNDATION SAN ANTONIO TX
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| We propose that genetic susceptibility to prostate cancer may be in part due to variations in the core circadian genes that regulate circadian rhythms and that serum sex steroid hormone levels modify the effect of circadian gene polymorphisms on prostate cancer risk. Our study is nested within the Prostate Cancer Prevention Trial (PCPT), a randomized placebo-controlled clinical trial to determine if finasteride (an inhibitor of androgen bioactivation) could prevent prostate ... |
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| Hepatitis C. Virus Infection: Mechanisms of Disease Progression |
OCT 2007 |
9 pages |
| Authors:
Maria H. Sjogren; Brooke Huntley; TRUE RESEARCH FOUNDATION SAN ANTONIO TX
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| An estimated 4.1 million individuals in the USA are chronically infected with the hepatitis C virus. Annually 8,000 to 10,000 of these subjects will die of liver-related complications and approximately 1,000 will require liver transplantation. The United States military have rates of HCV infection similar to the general US population (1.6%). However, it is a younger population and its natural history of HCV infection has not been studied. Therefore, the ... |
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| Contract Support and Facilitation of Epidemic Outbreak Surveillance (EOS) Program Final Operating Capability (FOC) |
AUG 2007 |
233 pages |
| Authors:
Brian McCarty; Lisa Lott; TRUE RESEARCH FOUNDATION SAN ANTONIO TX
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| After meeting the Advanced Concept Technology Development (ACTD) original developmental milestone objectives the portable molecular diagnostic (pMD) platform contract with Applied Biosystems (ABI) was terminated when the contractor was unwilling to seek FDA approval. ABI testing up to contract termination is included in this report. The EOS ACTD program initiated a technology review process and pre-validation testing to determine if other technology platforms could be developed in time to meet ... |
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| Development and Evaluation of New Products for the Far-Forward Care of Combat Casualities With Acute Lung Injury |
FEB 2007 |
21 pages |
| Authors:
Leopoldo C. Cancio; Brack Hattler; Andriy I. Batchinsky; TRUE RESEARCH FOUNDATION SAN ANTONIO TX
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| The principal objective for this phase of the study was to develop a new method of delivering chlorine gas for inhalation injury in sheep. Secondary objectives included the following: to assess the utility of the Suffolk breed of sheep for studies of inhalation injury; to demonstrate Optical Coherence Tomography (OCT) imaging of the trachea and bronchi following inhalation of chlorine, and to demonstrate Near-Infrared Diffuse Optical Spectroscopy (NIRS-DOS) monitoring of ... |
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| Hepatitis C. Virus Infection: Mechanisms of Disease Progression |
OCT 2006 |
9 pages |
| Authors:
Maria H. Sjogren; Brooke Huntley; TRUE RESEARCH FOUNDATION SAN ANTONIO TX
|
| An estimated 4.1 million individuals in the United States are chronically infected with the hepatitis C virus. Annually 8,000 to 10,000 of these subjects will die of liver-related complications and approximately 1,000 will require liver transplantation. The U.S. military has rates of HCV infection similar to the general U.S. population (1.6%). However, it is a younger population and its natural history of HCV infection has not been studied. Therefore, the ... |
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| Modulation of T Cell Tolerance in a Murine Model for Immunotheraphy of Prostatic Adenocarcinoma |
SEP 2006 |
28 pages |
| Authors:
Arthur A. Hurwitz; TRUE RESEARCH FOUNDATION SAN ANTONIO TX
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| The goal of this project is to characterize T cell tolerance to prostate tumor antigens and to identify the role of costimulatory receptors in overcoming this tolerance. Identification of these processes will assist in the development of novel therapeutic approaches for treating prostate cancer. We use the TRAMP model a transgenic mouse line that develops primary prostatic tumors due to expression of the SV4O T antigen (TAg) under the transcriptional ... |
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| Modulation of T Cell Tolerance in a Murine Model for Immunotheraphy of Prostatic Adenocarcinoma |
SEP 2006 |
28 pages |
| Authors:
Arthur A. Hurwitz; TRUE RESEARCH FOUNDATION SAN ANTONIO TX
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| The goal of this project is to characterize T cell tolerance to prostate tumor antigens and to identify the role of costimulatory receptors in overcoming this tolerance. Identification of these processes will assist in the development of novel therapeutic approaches for treating prostate cancer. We use the TRAMP model a transgenic mouse line that develops primary prostatic tumors due to expression of the SV4O T antigen (TAg) under the transcriptional ... |
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| Development and Evaluation of New Products for the Far-Forward Care of Combat Casualties with Acute Lung Injury |
01 FEB 2006 |
27 pages |
| Authors:
Leopoldo C. Cancio; Brack Hattler; Andriy I. Batchinsky; TRUE RESEARCH FOUNDATION SAN ANTONIO TX
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| OBJECTIVE: To evaluate the Intravenous Membrane Oxygenator or Hattler Catheter (IMO) in an ovine model of lung injury due to inhalation of chlorine gas. HYPOTHESIS: IMO will improve the PaO2-to-FiO2 (PFR) ratio in injured sheep. METHODS: Thirteen ewes (sham + IMO, n=1; injury + IMO, n=7; injury without IMO, n=5,) were used. Anesthetized sheep were ventilated with 300 L of 100 ppm chlorine (mixed in 100% O2). When animals reached ... |
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| Hepatitis C Virus Infection: Mechanisms of Disease Progression |
OCT 2005 |
8 pages |
| Authors:
Maria Sjogren; Brooke M. Huntley; TRUE RESEARCH FOUNDATION SAN ANTONIO TX
|
| An estimated 4 million individuals in the USA are chronically infected with the hepatitis C virus. Annually 8,000 to 10,000 of these subjects will die of liver-related complications and approximately 1,000 will require liver transplantation. The United States military have rates of HCV infection similar to the general US population (1.6%). However, it is a younger population and its natural history of HCV infection has not been studied. Therefore, the ... |
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| Development and Implementation of an Objective, Non-invasive, Behaviorally Relevant Metric for Laser Eye Injury |
Sep 2005 |
19 pages |
| Authors:
Gary L Martinsen; Cheryl D DiCarlo; John D'Andrea; HARRY ZWICK; Bruce Stuck; TRUE RESEARCH FOUNDATION SAN ANTONIO TX
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| The use of lasers by both the military and civilian community is rapidly expanding. Thus, the potential for laser eye injury and retinal damage is increasing. Sensitive and accurate methods to evaluate and follow laser retinal damage are needed. The multifocal electroretinogram (mfERG) has the potential to meet these criteria. In this study, the mfERG was used to evaluate changes to retinal function following laser exposure. Landolt C contrast acuity ... |
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| Prediction of Body Surface Area Based on 3-Dimensional Laser Scans |
MAR 2005 |
10 pages |
| Authors:
James a. Hodgdon; Martine Brandsma; Hein Daanen; Linda Hervig; TRUE RESEARCH FOUNDATION SAN ANTONIO TX
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| Treatment of many military-relevant diseases depends on knowledge of body surface area (BSA). ESA is typically estimated using predictive formulae that were developed using a variety of measurement techniques. More recently, techniques to use the 3-D laser scanner to provide precise measurement of ESA have been developed. The objectives of this study are to accomplish the following: (1) collect measurements of ESA from whole-body laser scans, (2) determine the accuracy ... |
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| Development and Evaluation of New Products for the Far-Forward Care of Combat Casualties With Acute Lung Injury |
FEB 2005 |
27 pages |
| Authors:
Leopoldo C. Cancio; TRUE RESEARCH FOUNDATION SAN ANTONIO TX
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| To characterize the acute respiratory distress syndrome (ARDS) caused by chlorine gas (Cl2). Toxic industrial chemicals (TICs) have recently been identified as potential terrorist weapons. Several TICs act primarily on the respiratory tract, but more work is needed to define the pathophysiology and treatment of these injuries. Anesthetized female sheep (n=35, 42.4kg +/- 5.4 SD) were ventilated with 300 L of a Cl2/air/oxygen mixture over 30 min. Doses were: 0 ... |
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| Hepatitis C. Virus Infection: Mechanism of Disease Progression |
OCT 2004 |
7 pages |
| Authors:
Maria H. Sjogren; TRUE RESEARCH FOUNDATION SAN ANTONIO TX
|
| An estimated 4 million individuals in the USA are chronically infected with the hepatitis C virus. Annually 8,000 to 10,000 of these subjects will die of liver-related complications and approximately 1,000 will require liver transplantation. The United States military nave rates of HCV infection similar to the general US population (1.6%). However, it is a younger population and its natural history of HCV infection has not been studied. Therefore, the ... |
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| Development and Implementation of an Objective Noninvasive Behaviorally Relevant Metric for Laser Eye Injuries |
SEP 2004 |
25 pages |
| Authors:
Cherly DiCarlo; Gary Martinsen; John D'Andrea; Harry Zwick; Bruce E. Stuck; TRUE RESEARCH FOUNDATION SAN ANTONIO TX
|
| Battlefield and accidental laser-induced retinal injuries can produce significant retinal scarring and permanent vision loss. Lasers have become an integral part of military weapon system. The proliferation of lasers in battlefield and workplace environments increases the probability that ground and air crews will acquire laser-induced deficits in visual function. The objective of this research are three-fold. The first, is to use a modification of an existing behavioral technique to assess ... |
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| Prediction of Body Surface Area Based on 3-Dimensional Laser Scans |
MAR 2004 |
6 pages |
| Authors:
James A. Hodgdon; TRUE RESEARCH FOUNDATION SAN ANTONIO TX
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| Treatment of many military-relevant diseases depends on knowledge of body surface area (BSA). BSA is typically estimated using predictive formulae that were developed using a variety of measurement techniques. These techniques range from applying paper to the surface of the body and measuring the contact area to measuring the reflectance area of the skin with bright light. More recently, a technology, the 3-D laser scanner, has been developed which allows ... |
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| Hepatitis C Virus Infection: Mechanism of Disease Progression |
OCT 2003 |
7 pages |
| Authors:
Maria H. Sjogren; Brooke M. Huntley; TRUE RESEARCH FOUNDATION SAN ANTONIO TX
|
| An estimated 4 million individuals in the USA are chronically infected with the hepatitis C virus. Annually 8,000 to 10,000 of these subjects will die of liver-related complications and approximately 1,000 will require liver transplantation. The United States military high rates of HCV infection similar to the general US population (1.6%). However, it is a younger population and its natural history of HCV infection has not been studied. Therefore, the ... |
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| Efficacy of Countermeasures Against Traumatic Brain Injuries Sustained in Airborne Operations |
JUN 2003 |
20 pages |
| Authors:
John S. Crowley; TRUE RESEARCH FOUNDATION SAN ANTONIO TX
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| Airborne operations regularly expose paratroopers to risk of head impact. Even relatively mild head impacts, while not life threatening, can cause short-term impairment from dizziness, headaches, memory loss, lack of ability to concentrate, and irritation. These symptoms jeopardize soldier survivability and mission success. There is an obvious need to protect the soldier in these environments and reduce the head injury rate to a minimum. The objectives of this research program ... |
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| Hepatitis C Virus Infection: Mechanism of Disease Progression |
OCT 2001 |
6 pages |
| Authors:
Maria H. Sjogren; Kent Holtzmuller; TRUE RESEARCH FOUNDATION SAN ANTONIO TX
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| This proposal focuses on: (1) Effect of different HCV genotype infection in active duty military subjects. (2) Factors associated with progressive liver disease, (3) Liver histology progression of disease, (4) Laboratory evaluations on virologic and immunological markers of disease, (5) Detailed risk factor questionnaires, health survey and quality of life questionnaires. To date, 41 active duty subjects are enrolled in the study. It is premature to draw conclusions on this ... |
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