TEXAS UNIV MEDICAL BRANCH AT GALVESTON CENTER FOR BIODEFENSE AND EMERGING INFECTIOUS DISEASES (CBEID)

Genetic Characterization of Zika Virus Strains: Geographic Expansion of the Asian Lineage

28 Feb 2012

8 pages

Authors: Andrew D Haddow; Amy J Schuh; Chadwick Y Yasuda; Matthew R Kasper; Vireak Heang; Rekol Huy; Hilda Guzman; Robert B Tesh; Scott C Weaver; TEXAS UNIV MEDICAL BRANCH AT GALVESTON CENTER FOR BIODEFENSE AND EMERGING INFECTIOUS DISEASES (CBEID)

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Zika virus (ZIKV) is a mosquito-borne flavivirus distributed throughout much of Africa and Asia. Infection with the virus may cause acute febrile illness that clinically resembles dengue fever. A recent study indicated the existence of three geographically distinct viral lineages; however this analysis utilized only a single viral gene. Although ZIKV has been known to circulate in both Africa and Asia since at least the 1950s, little is known about ...

A Novel, Rapid Assay for Detection and Differentiation of Serotype-Specific Antibodies to Venezuelan Equine Encephalitis Complex Alphaviruses

Jan 2005

7 pages

Authors: Eryu Wang; Slobodan Paessler; Darci R Smith; Lark L Coffey; Wenli Kang; Jose Estrada-Franco; Scott C Weaver; Patricia V Aguilar; Martin Pfeffer; James Olson; TEXAS UNIV MEDICAL BRANCH AT GALVESTON CENTER FOR BIODEFENSE AND EMERGING INFECTIOUS DISEASES (CBEID)

An epitope-blocking enzyme-linked immunosorbent assay was developed for the rapid differentiation of serologic responses to enzootic variety IE and ID versus epizootic variety IAB and IC strains of Venezuelan equine encephalitis (VEE) virus. Two monoclonal antibodies that differentially recognize epizootic versus enzootic VEE virus epitopes were used to measure the serotype-specific blocking abilities of antibodies in sera of naturally infected humans, equines, and bovines, as well as in experimentally infected ...